+34 620 10 75 37info@nanbiosis.com
Encapsulation of therapeutic actives of interest in formulations for pulmonary administration with possibility of lyophilisation to obtain a powder. The service has two cutting-edge equipments for the characterization of pulmonary formulations:
SprayTec laser diffraction system: allows the measurement of spray particle and spray droplet size distributions in real-time for more efficient product development of sprays and aerosols, with robust and reproducible droplet size data.
Next Generation Impactor: has been designed specifically for the pharmaceutical industry for testing metered-dose inhalers, drypowder inhalers, nebulizers and nasal sprays. It consists of a high performance cascade impactor for classifying aerosol particles into micrometer size fractions, providing relevant information about their distribution in the respiratory tract.
Customer benefits
The formulations can be characterized, following SOPs, in terms of particle size, polydisperstity index and zeta potential. Importantly, this service can also offer real-time droplet size distribution and aerosol particles classification analysis by means of SprayTec and Next Generation Impactor (NGI) technology.
Target customer
References
Moreno-Sastre M, Pastor M, Esquisabel A, Sans E, Viñas M, Fleischer A, Palomino E, Bachiller D, Pedraz JL. Pulmonary delivery of tobramycin-loaded nanostructured lipid carriers for Pseudomonas aeruginosa infections associated with cystic fibrosis. Int J Pharm. 2016 Feb 10;498(1-2):263-73. doi: 10.1016/j.ijpharm.2015.12.028.
Additional information
The principle of 3D bioprinting consists of selecting the most suitable biomaterials and cell types to prepare a Bioink that should be able to promote cell growth and differentiation and present appropriate mechanical properties of the target tissue.
This service possess a wide variety of 3D bioprinting techniques avaliable, such as extrusion, droplet, electrospining, electrowritting and stereolithography.
Customer benefits
One of the main characteristics of this additive manufacturing technique is its ability to bioprint the desired layers, with specific cell orientation , and desired morphology of the bioprinted 3D scaffold in order to ressemble, as much as possible, the tissue of interest. To achieve this goal, rheology, texturometry, printability and biological assays are carried out.
On the one hand, this technology can be employed to develop 3D scaffolds specific for the regeneration of particular tissues. On the other hand, this strategy offers a 3D environment that mimics the tissue/ organ of interest in order to test potential therapeutic tools, which goes in accordance with the implementation of the 3R principle (replace, reduce and refine).
Target customer
References
Additional information
1) NGI Cascade Impactor: It’s an analytical tool for the development of inhalation products. It’s use for the testing of all inhalation formulations and devices: MDIs, DPIs, nebulizers and aerosol and nasal sprays. It’s the new “workhorse” of the pharmaceutical industry.
2) Alberta Idealised Throat (AIT): before entering the lungs, aerosols must traverse the mouth-throat. So it’s important to be able to mimic aerosol deposition and flow in the human mouth-throat when studying inhaled aerosols. The Alberta geometry has been shown to do a remarkable job of mimicking the aerosol and flow motion in the human mouth-throat and allow researchers examining and testing aerosols inhaled orally.
3) Breath Simulator: are increasingly used in testing orally inhaled and nasal drug products (OINDPs) to replace existing constant flow conditions with breathing profiles more representative of conditions in vivo. It can be used for improved IVIVC applications, with real breath profiles generated in clinic.
Climate chambers are needed because our laboratory is able to carry out stability studies in climatic chambers under ICH conditions and with access to Good Laboratory Practice (GLP).
