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Rosa Hernández of the NanoBioCel group-NANBIOSIS U10 has received the Female Talent Award 2023 Women and Science

On Thursday, November 2, the Female Talent Award, in the category of Women and Science, was awarded to Rosa Hernández from the NanoBioCel group of CIBER BBN and the U10 Drug Formulation Unit. The award is given by AMPEA (Association of Professional and Business Women of Alava).

In her award speech, Rosa Hernández, highlighted that the effort and work carried out during all these years has allowed the research group to develop cutting-edge research and to place the names of the University of the Basque Country (UPV/EHU) and Vitoria-Gasteiz on the map of cutting-edge research in Nanotechnology and Regenerative Medicine.

She also stressed that: “awards like this allow society to get to know us, to know what we do in our laboratories and gives us a lot of visibility so that girls and young women begin to have female references in science and will be encouraged to choose, in the future, a scientific career”.

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Impactful research with NANBIOSIS participation in the Poster Tour of CIBER-BBN & CIBEREHD Annual Conference.

2023 CIBER-BBN Annual meeting has taken place at Santemar Hotel, in Santander during November 6-7. This year the format of our annual conferences has been changed towards a collective event scheme between the CIBER-BBN and CIBEREHD thematic areas.

  • On Monday 6 the scientific sessions werecommon for EHD and BBN, with appealing contents for the mixed audience.
  • On Tuesday 7 EHD and BBN sessions will specific for each area in separate rooms (with common coffee break).

Posters of both areas were on display in the exhibit hall throughout the entirety of the Annual Meeting.

Moreover, at the “Posters & beers” session (Monday 6th: 6:00 p.m. – 7:00 p.m.) poster tours were organized where attendees could cast their vote for the best poster and use this one-on-one time with presenters to learn more, ask juicy questions and discuss their work. At 8:00 p.m., the awards ceremony took place for the best oral communication and best poster by young authors – for each area.

It was an impactful information sessions on research carried out by the groups of CIBER-BBN and CIBEREHD thematic areas.

The poster session is always a popular feature at CIBER-BBN Annual Meeting for acknowledgment NANBIOSIS units’ participation in the research carried out during the year. These are the works presented in 2023:

Targeted nanotoxin for the selective depletion of CXCR4+ cancer cells and immune cell recruitment in a colorectal cancer mouse model. Luis Miguel Carrasco-Díaz, Naroa Serna, Eric Voltà-Durán, Ugutz Unzueta, Esther Vázquez, Antonio Villaverde, Patricia Álamo, Lorena Alba-Castellón, Ramón Mangues. With participation of NANBIOSIS Units U1 Protein Production Platform (PPP) and U18 Nanotoxicology Unit . (Contact:
luismiguelcarrascodiaz@gmail.com)

Improvement of the biodistribution of GLA enzyme by RGD-functionalized nanoGLA in a Fabry mouse model.
Zamira Vanessa Diaz Riascos, Marc Moltó Abad, Daniel Marijuan, Belen García Prats, Judit Tomsen Melero, Elisabet González Mira, Jose Luis Corchero, Andreu Soldevila, Miriam Royo, Alba Córdoba, Nora Ventosa, Guillem Pintos Morell, Simo Schwartz , Ibane Abasolo. With participation of the NANBIOSIS units U20 FVPR-In Vivo Experimental Platform, U3 Synthesis of Peptides Unit and U6 Biomaterial Processing and Nanostructuring Unit. (Contact:
vanessa.diaz@vhir.org)

An auristatin-based nanoconjugate induces apoptosis and inhibits the bone marrow leukemia burden in an acute myeloid leukemia mouse model. Annabel Garcia-León, Julián I. Mendoza, Ariana Rueda, Luis Carlos Navas, Vanessa Huaca, Ugutz Unzueta, Jorge Sierra, Esther Vázquez, Antonio Villaverde, Ramon Mangues, Isolda Casanova. With participation of NANBIOSIS Units U1 Protein Production Platform (PPP) and U18 Nanotoxicology Unit. (Contact: agarciale@santpau.cat)

FVPR/U20-NANBIOSIS Service Platform: from the Synthesis and Characterization of Nanotechnology-based Therapies, to the in vitro and in vivo Preclinical Validation. Diana Rafael, Zamira V. Diaz Riascos, Belén García, Alejandra Palacios, Sandra Mancilla, Laura Garcia, Ibane Abasolo. Description of NANBIOSIS Unit 20 FVPR-In Vivo Experimental Platform. (Contact: diana.fernandes_de_so@vhir.org)

Non-Viral Vector Development for Gene Therapy in the Treatment of Congenital Liver Metabolic Diseases Lucía Enríquez Rodríguez, Isabel Carbonell Simón, Idoia Gallego Garrido, Virginia Nieto Romero, Iván Maldonado Pérez, Aida Garcia Torralba, Gustavo Puras Ochoa, Miruna Giurgiu, Jose Carlos Segovia Sanz, María García Bravo, Oscar Quintana Bustamante, José Luis Pedraz Muñoz. With participation of NANBIOSIS U10 Drug Formulation unit. (Contact: lucia.enriquez@ehu.eus)

X-ray Photoelectron Spectroscopy (XPS) Analysis of Nitrogen Environment in Small Extracellular Vesicle Membranes: A Potential Novel Technique with Application for Cancer Screening.
Ana Martín-Pardillos, María Sancho-Albero , Silvia Irusta , Víctor Sebastián , Vicente Luis Cebolla , Roberto Pazo-Cid , Pilar Martín-Duque , Jesús Santamaría. With participation of NANBIOSIS U9 Synthesis of Nanoparticles Unit. (Contact: a.martin_pardillos@unizar.es)

Nanoparticle-based approach for blood-brain-barrier crossing and glioblastoma treatment. Júlia German-Cortés, Raquel Herrero, Diana Rafael, Ibane Abasolo, Fernanda Andrade. With participation of NANBIOSIS Unit 20 FVPR-In Vivo Experimental Platform. (Contact: fernanda.silva@vhir.org)

Exploiting mammalian cells for recombinant protein production: an improved protocol for transient gene expression. Aida Carreño Fibla, Roger Fernández Palomeras, José Luis Barra, Rosa Mendoza Moreno, Mercedes Márquez Martínez, Neus Ferrer-Miralles, Antonio Villaverde Corrales, José Luis Corchero Nieto. With participation of NANBIOSIS Units U1 Protein Production Platform (PPP). (Contact:jlcorchero@ciber-bbn.es)

Surface characterization of a PLA/Qr/Mg biocomposite after in vitro degradation in m-SBF. Juan Manuel Casares-López, Margarita Hierro-Oliva, Verónica Luque-Agudo, Amparo M. Gallardo-Moreno, María Luisa González-Martín. With participation of Unit 16 Surface Characterization and Calorimetry Unit (Contact: mlglez@unex.es)

The poster session was an effective forum for the exchange of information and a means to communicate ideas

Related news:

2023 Annual Conference of CIBER-BBN and NANBIOSIS with CIBEREHD
2023 Annual Conference of CIBER-BBN and NANBIOSIS
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Developing Support Technologies for adressing traslational gaps in regenerative medicine.

On the 20th of October, CIBER-BBN group NanoBioCell – NANBIOSIS U10 Drug Formulation unit organises the Conference “Developping support technologies for adressing traslational gaps in regenerative medicine” by Dr. James-J Yoo.

The Conference will take place in the Assembly hall of the Faculty of Pharmacy on Friday 20th of October, 2023 from 12:00 to 13:00, as part of the JRL program Advanced Pharma Development. The Conference will be broadcasted.

Dr. Yoo is Professor and Associate Director of the Wake Forest Institute for Regenerative Medicine (WFIRM), with cross-appointments to the Departments of Urology, Physiology and Pharmacology, Clinical and Translational Science Institute, and the Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences. He is also an elected Fellow of the American Institute for Medical and Biological Engineering (AIMBE).

Dr. Yoo’s research efforts have been directed toward developing tissue engineering technologies and therapeutic approaches for clinical translation. A few notable examples of successful clinical translation include the bladder, urethra, vagina, and muscle cell therapy for incontinence.

Dr. Yoo has been a lead scientist in the bioprinting program at WFIRM and has been instrumental in developing skin bioprinting and integrated tissue and organ printing (ITOP) systems for preclinical and clinical applications.

He and his teams were recently awarded first and second place in NASA Centennial Vascular Tissue Challenge for bioprinting metabolically active thick liver tissue that retained function for thirty days.

Dr. Yoo has authored more than 340 scientific publications, 100 patent registrations/applications, 1000 scientific presentations, 310 invited lectures and mentored over 320 trainees, ranging from undergraduate students to practicing physicians

For further information contact: Angela.Losada@ehu.eus

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3D Printing and Bioprinting for Pharmaceutical and Medical Applications

Researchers of CIBER-BBN group NanoBioCell – NANBIOSIS U10 Drug Formulation unit Jose Luis Pedraz Muñoz, Laura Saenz del Burgo Martínez, Gustavo Puras Ochoa, Jon Zarate Sesma have edited the book “3D Printing and Bioprinting for Pharmaceutical and Medical Applications”

The increasing availability and decreasing costs of 3D printing and bioprinting technologies are expanding opportunities to meet medical needs. 3D Printing and Bioprinting for Pharmaceutical and Medical Applications discusses emerging approaches related to these game-changer technologies in such areas as drug development, medical devices, and bioreactors.

Key Features:

  • Offers an overview of applications, the market, and regulatory analysis
  • Analyzes market research of 3D printing and bioprinting technologies
  • Reviews 3D printing of novel pharmaceutical dosage forms for personalized therapies and for medical devices, as well as the benefits of 3D printing for training purposes
  • Covers 3D bioprinting technology, including the design of polymers and decellularized matrices for bio-inks development, elaboration of 3D models for drug evaluation, and 3D bioprinting for musculoskeletal, cardiovascular, central nervous system, ocular, and skin applications
  • Provides risk-benefit analysis of each application
  • Highlights bioreactors, regulatory aspects, frontiers, and challenges

This book serves as an ideal reference for students, researchers, and professionals in materials science, bioengineering, the medical industry, and healthcare.

For table of contents and further deatails:

3D Printing and Bioprinting for Pharmaceutical and Medical Applications. ISBN 9781032228662332 Pages 73 B/W Illustrations. Published September 27, 2023 by CRC Press

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The role of microfluidics and 3D-bioprinting in the future of exosome therapy. A high impact review

Researchers of the NanoBioCel research group of the University of the Basque Country (UPV/EHU) and CIBER BBN, belonging to NANBIOSIS U10 Drug Formulation, Bioaraba, and CONICET Foundation of Argentina, have collaborated in a studio entitled: “The role of microfluidics and 3D-bioprinting in the future of the exosome therapy” which has been published in the journal Trends in Biotechnology, whose editorial seeks particularly relevant articles.

The importance of this publication lies in the novelty and potential of nanovesicles as new therapeutic agents and the versatility of microfluidic technology in combination with 3D bioprinting to bring nanovesicles closer to the clinic.

Article of reference:

Mikele Amondarain, Idoia Gallego, Gustavo Puras, Laura Saenz-del-Burgo, Carlos Luzzani, José Luis Pedraz, “The role of microfluidics and 3D-bioprinting in the future of exosome therapy”, Trends in Biotechnology,
2023, ISSN 0167-7799
https://doi.org/10.1016/j.tibtech.2023.05.006.

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Three articles acknoledging NANBIOSIS contribution awarded at the Bioaraba Research and Innovation Conference

Researchers of NANBIOSIS U10 “Drug Formulation” – NanoBiocel research group from CIBER-BBN and UPV/EHU receives 3 awards in the category of Best International Articles at the annual Bioaraba Research and Innovation Conference.

On 4 November, the Bioaraba Health Research Institute held its XXIII Research and Innovation Conference in Vitoria. This important annual forum held in the city brings together professionals from the health system of Alava, the Rioja region of Alava, the Mental Health Network of Alava, the University of the Basque Country and also professionals from companies in R&D&I in health.

On this occasion, the NanoBioCel research group of the CIBER BBN and the ICTS Nanbiosis through the U10 Drug Formulation, won the 3 prizes in the category of Research and Innovation in the category of Best International Article. The first prize went to the article: Mesenchymal stromal cells encapsulated in licensing hydrogels exert delocalized systemic protection against ulcerative colitis via subcutaneous xenotransplantation. Written by Ainhoa Gonzalez-Pujana, Ana Beloqui, José Javier Aguirre, Manoli Igartua, Edorta Santos-Vizcaino, Rosa Maria Hernandez, published in the European Journal of Pharmaceutics and Biopharmaceutics in 2022. The second prize went to the article Nanodiamond Integration into Niosomes as an Emerging and Efficient Gene Therapy Nanoplatform for Central Nervous System Diseases whose authors are: Nuseibah AL Qtaish, Idoia Gallego, Alejandro J. Paredes,Ilia Villate, Cristina Soto-Sánchez, Gema Martínez, Myriam Sainz-Ramos, Tania B. López, Eduardo Fernández, Gustavo Puras, José Luis Pedraz. And the third prize went to the review: Cell microencapsulation technologies for sustained drug delivery: Latest advancesin efficacy and biosafety whose authors are: Tania B. López, Edorta Santos, José Luis Pedraz, Gorka Orive, Rosa María Hernández.

Articles of refernce:

Ainhoa Gonzalez-Pujana, Ana Beloqui, José Javier Aguirre, Manoli Igartua, Edorta Santos-Vizcaino, Rosa Maria Hernandez, “Mesenchymal stromal cells encapsulated in licensing hydrogels exert delocalized systemic protection against ulcerative colitis via subcutaneous xenotransplantation“, European Journal of Pharmaceutics and Biopharmaceutics, Volume 172,
2022, https://doi.org/10.1016/j.ejpb.2022.01.007

Nuseibah AL Qtaish, Idoia Gallego, Alejandro J. Paredes, Ilia Villate-Beitia, Cristina Soto-Sánchez, Gema Martínez-Navarrete, Myriam Sainz-Ramos, Tania B. Lopez-Mendez, Eduardo Fernández, Gustavo Puras, José Luis Pedraz. “Nanodiamond Integration into Niosomes as an Emerging and Efficient Gene Therapy Nanoplatform for Central Nervous System Diseases” ACS Appl. Mater. Interfaces 2022, 14, 11, 13665–13677 https://doi.org/10.1021/acsami.2c02182

Tania B. Lopez-Mendez, Edorta Santos-Vizcaino, Jose Luis Pedraz, Gorka Orive, Rosa Maria Hernandez, “Cell microencapsulation technologies for sustained drug delivery: Latest advances in efficacy and biosafety,
Journal of Controlled Release”, Journal of Controlled Release, Volume 335, 10 July 2021, Pages 619-636 https://doi.org/10.1016/j.jconrel.2021.06.006


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II Scientific Communication course

On October 18 and 19, was held the second course on Social Communication of Science, orgnized by NANBIOSIS U10 Drug Formulation Unit -(NanoBioCell Group of CIBER-BBN and UPV-EHU, this year entitled “Tools for the social communication of science“. The course aimed to provide doctoral students with communication with tools to be employed in their work as scientists when communicating their results or activity to the general public, patients, etc.

They first day was mainly dedicated to the use of metaphors in science communication, starting with an interesesting talk by Susana Martinez, director of the Incite Foundation; ateendees had the opportuniy to work case studies. On the second day, there were two different sessions: the first one about how to communicate science on the radio, led by the journalist Eva Caballero from the EiTB regional program “The mechanics of the snail”. and during the second session, a practical workshop was led by the group of theather “Porpol”, about on how to combat the stage fright.

This course was offered at the Doctoral School of the University of the Basque Country.

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The sprint of the European Project Moore4medical

The NanoBioCel group of the CIBER BBN, which also runs NANBIOSIS U10 Drug Formulation unit , organized the Workshop #6 of the Moore4medical European project at the Alava Technology Park on October 4, 5 and 6

The Central Building of the Álava Technology Park hosted the ‘Workshop #6’ of the European project which. 80 people belonging to 68 organizations, including private companies and research groups from universities and research centers from 13 countries of the European Union, participated in a meeting that has the leadership of the Dutch multinational Philips in its divisions of electronics and medical systems and service innovation

Moore4Medical Project
The three-year Moore4Medical project is funded by the public-private association ECSEL (Electronic Components and Systems for European Leadership), which manages a research and innovation program to strengthen the electronic components and systems sector in order to maintain the European Union at the forefront of technological development. The goal of the project is to accelerate innovation in electronic and microfabricated devices for various emerging medical specialties. The total financing of the project amounts to 68 million euros, of which more than half a million have been granted to the work of NanoBiocel.

NanoBiocel research group

The NanoBiocel research group from UPV/EHU, which is part of the CIBER BBN and the ICTS Nanbiosis through the U10 Drug Formulation, is led by Professor Jose Luis Pedraz, from the Faculty of Pharmacy of the Álava Campus. He participates in the European project Moore4medical on the optimization of the lyophilization process of biopharmaceutical products in microfluidic devices

Microfluidic Device
The University of the Basque Country is working, together with the Mondragón microLIQUID company, on the development of technology for the integration of lyophilized drugs and their rehydration in a microfluidic device for their correct administration. The lyophilized drug will be integrated into the microfluidic device using specific techniques to ensure good interaction between the fluid and the drug for delivery by the pump. The ultimate goal is to design a parenteral drug administration system that is much more comfortable for patients and improves therapeutic compliance with treatments.

The microLIQUID company is a benchmark biotechnological company in the microfluidic technology sector and is responsible for the design and development of microfluidic modules.

In this work called ‘Drug Adherence’, integrated within the total project, the NanoBioCel group has teamed up with the Irish national institute Tyndall, the pharmaceutical multinational AbbVie, the Fraunhofer Institute of Germany, the services innovation section of Philips, the German company Gaudlitz GmbH, specialist in polymers, the Technological Institute Karlsruhe in Germany and the company HI Iberia of Madrid.

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CRISPR technologies for Cystic Fibrosis treatment

Cystic fibrosis is an inherited genetic disease that mainly affects the lungs and the digestive system

On April 6, the first meeting was held, on the one hand, with people with Cystic Fibrosis and the Euskadi Cystic Fibrosis Association (Arnasa) and, on the other, with the NanoBioCel research group of the CIBER-BBN and the University of Basque Country, which is also part of the ICTS Nanbiosis through the Drug Formulation Unit U10.

The cooperative relationship between the NanoBioCel research group and Arnasa began approximately 5 years ago with the contributions made by the association to the NanBioCel group for research in cystic fibrosis.

The goup has focused on the development of non-viral vectors to address the treatment of cystic fibrosis through gene therapy. Progress is currently being made in the development of CRISPR technologies for its treatment.

This meeting was organized with the main objective of making those affected aware of the research carried out by NanoBioCel in cystic fibrosis and promoting associationism and collaboration between affected people and researchers to better understand the disease and find promising solutions.

The event was attended by almost 28 associates and many of the rest requested that the presentation of the researchers be recorded

Arnasa is the Cystic Fibrosis Association of the Basque Country and contributes with its work and activities to the promotion of general interest and the visibility of the disease, as well as to the improvement of the quality of life of people affected by the disease and their families.

In the picture: Increased activity of the chloride channel in CUFI cells transfected with non-viral vectors.

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1st Meeting with Cystic Fibrosis Patiens (NanoBioCel -ARNASA)

Cystic Fibrosis is a genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. It is a genetic, degenerative and chronic disease, with a population incidence is 1 in 5,000, so it is considered among the so called “Rare Diseases”

The most common symptoms are continuous colds, repeated infections, decreased lung capacity, impossibility of fat absorption and malnutrition

As there is no cure for the disease, daily treatment is the only option to have an acceptable quality of life

The NanoBioCell Research Group, which coordinates unit 10 of NANBIOSIS of the CIBER-BBN and the UPV/EHU, has a wide experience in comprehensive research into effective therapies for the treatment of cystic fibrosis and related diseases has organized the ‘First meeting with cystic fibrosis patients’ in the collaboration with ARNASA Bizkaia, (the Cystic Fibrosis Association of Bizkaia, made up of affected people, their families and volunteers who collaborate with the association)

Registration is free here. After registration you will receive a link to the online meeting

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