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Preclinical validation characterization - Equipment

Preclinical validation characterization – Equipment

U12-E12. BX51TRF6 Olympus Optical Microscope

U12-E12. BX51TRF6 Olympus Optical Microscope

Description:
Optical microscope that can work with transmitted or reflected light. Different observation methods can be used: bright field, dark field, phase contrast, differential interference contrast, polarized light, and fluorescence. It includes two revolvers to work at short or long distances. Moreover, it is equipped with a digital camera (Olympus DP73) connected to the computer with a software that captures images and videos.

Applications:

Observation of samples at microscale

U12-E12
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U12-E11. Densitometer DMA 4500M (Anton Paar)

U12-E11. DMA -46 densitometer (Anton Paar)

Description:

Instrument for the Determination of the density of liquid samples using Pulsed Excitation. It is a highly precise instrument, measuring density by the method of resonance vibration frequency of a glass capillary.

Applications:

Measurement of the density of liquid samples at controlled temperature

U12-E11. DMA -46 densitometer (Anton Paar)
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U12-E10. Optilab rEX Differential Refractometer

U12-E10. Optilab rEX Differential Refractometer

Description:
The Optilab® rEX (refractometer with EXtended range) is a Refractive Index measurement system. It has a flow cell with a total volume of only 7.4 µL. This translates into minimized band broadening and better temperature stability. It can measure the absolute refractive index of a solution. In addition, it can measure the dn/dc of a solvent at a fixed wavelength. The light source in the rEX can be replaced for other wavelengths (e.g. 690, 633, 488 nm, etc.). The temperature can be programmed from 4°C to 50°C. It is compatible with all HPLC systems.

Applications:
Refractive Index determination, mainly of liquid samples, can be useful in measurements of other techniques (Dynamic Light Scattering as an example). It can be also possible to calculate the refraction index as a function of concentration for a compound. This can allow you to determine the purity or concentration of the compound which is dissolved in a liquid.

U12-E10. Optilab rEX Differential Refractometer
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U12-E09 Sigma 701 force tensiometer (Biolin Scientific) for the measurement of surface and interfacial tensions, wettability and critical micelar concentration

U12-E09 Sigma 701 force tensiometer (Biolin Scientific) for the measurement of surface and interfacial tensions, wettability and critical micelar concentration

Description:
High resolution force tensiometer with software for control, acquisition and data treatment for the measurement of surface and interfacial tensions, as well as the automatic determination of critical micellar concentrations. It is equipped with Wilhelmy plate and Du Nouy ring accessories. It can also measure contact angle on powder samples (Washburn method)


Applications:
Surface and interfacial tension determination of liquid systems. Contact angle determination of liquids on single fibers (fiber diameter greater than 20 mm), solid (cylindrical or plate shapes) and porous materials (cylindrical or plate shapes).

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U12-E08. Contact angle goniometer and drop shape analyzer

U12-E08. Contact angle goniometer and drop shape analyzer

Description:
Electrobalance for determination of surface tensions (liquid/gas) and interfacial tensions (liquid/liquid) porpoises.

Applications:
Determination of surface tensions (liquid/gas) and interfacial tension (liquid/liquid).

U12-E08. K12 tensiometer with Wilhelmy plate and du Noüy ring (Krüss)
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U12-E07. SITE Spinning Drop Interfacial Tensiometer

U12-E07. SITE Spinning Drop Interfacial Tensiometer

Description:
Instrument for determination of liquid-liquid interfacial tensions by the spinning drop method

Applications:
Determination of ultra-low interfacial tensions (up to 10-5 mN.m-1) in colloidal liquid-liquid biphasic systems at controlled temperature.

U12-E07. SITE Spinning Drop Interfacial Tensiometer
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U12-E06. S3 Micro SAXS/WAXS Small and Wide Angle X-Ray Spectrometer

U12-E06. S3 Micro SAXS/WAXS Small and Wide Angle X-Ray Spectrometer

Description:
S3 MICRO instrument (Hecus X-ray Systems, Graz, Austria) for determinations of X-ray scattered intensity as a function of scattering angle. This instrument is equipped with a GENIX microfocus X-ray source and a FOX 2D point-focusing element (both from Xenocs, Grenoble). It can measure simultaneously at small angle (0,2º-8º) and wide angle (18º-28º).

Applications:
Structural characterization of materials within the nanometer range. This includes determination of symmetry, morphology, characteristic size, fractal dimension and surface area. These studies can be applied to liquid crystals, micellar aggregates, mesoporous materials, nanoparticles, proteins and nanostructured films.

U12-E06. S3 Micro SAXS/WAXS Small and Wide Angle X-Ray Spectrometer
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U12-E05. Mastersizer 2000 Light Diffractometer

U12-E05. Mastersizer 2000 Light Diffractometer

Description:
Instrument Mastersizer 2000 that measures by means of laser diffraction the size and distribution of particles or droplets in suspension. It is equipped with a liquid dispersing unit for small volume (Hydro 2000G) to measure emulsions, dispersions, etc. and a solid dispersion unit (Scirocco) to analyse dried powders. It is equipped with a software (windows operated) for the data processing to obtain the characteristic size (droplet, particle) and its distribution.

Applications:
Determination of the droplet/particle diameter for emulsions, suspensions and solid samples (powder) in the range of 100 nm – 2000 mm. The results are expressed in standard percentiles D(v,0.1), D(v0.5), D(v0.9), mean volume diameter (D[4,3]), mean surface diameter (Sauter mean diameter, D[3,2]), specific surface area (SSA), etc.

U12-E05. Mastersizer 2000 Light Diffractometer
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U12-E04. Malvern 4700 Spectrometer

U12-E04. Malvern 4700 Spectrometer

Description:
Photon Correlation Spectrometer (PCS) that allows to measure dynamic (DLS) and static (SLS) light scattering. The radiation source is an Ar laser. The instrument is equipped with a temperature controller for measurements in the 5-90 ºC range. The software for data treatment includes CONTIN and REPES algorithms.

Applications:
Determination of particle size and shape, size distribution, etc. in colloid systems (e.g. solid dispersions, micelles, microemulsions, nano-emulsions, polymers, vesicles or liposomes) in the 2-1000 nm range. Estimation of molecular weight.

U12-E04. Malvern 4700 Spectrometer
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U12-E03. AR-G2 Rheometer

U12-E03. AR-G2 Rheometer

Description:
Rheometer with magnetic bearings which allows measuring torques down to 0.003 N.m. It can perform either stress controlled or strain controlled measurements. The angular velocity range is 2×10-7 to 628 rad/s. The maximum measurable torque is 200 mN.m, with a resolution of 0.1 nN.m. Several geometries are available, such as concentric cylinders, cone-plate, plate-plate (different sizes) and also cross hatched plates which are suitable to measure gel samples. Temperature is controlled with a Peltier system (from -20ºC to 200ºC) and with a Upper heating plate device. There is also an interfacial rheometry accessory. The instrument’s software enables to perform a wide variety of tests and analyses.

Applications:
Determination of viscosities from flow curves (stress vs shear rate); estimation of storage (elastic) modulus and loss (viscous) modulus, creep assays, temperature ramps; Determination of gel and glass points; Estimation of interfacial viscosity and moduli.

U12-E03. AR-G2 Rheometer
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