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Preclinical validation tissue, biomaterialls and surfaces characterization -Services

Preclinical validation tissue, biomaterialls and surfaces characterization -Services

U19-S02. Clinical Analysis Laboratory (On-site&Remote) OUTSTANDING

Clinical Analysis Laboratory

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U14-S06. Lymphocyte proliferation assay (On-site&Remote) OUTSTANDING

Lymphocyte proliferation assay

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U14-S05. Determination of cytokine concentration by flow cytometry (On-site&Remote) OUTSTANDING

Determination of cytokine concentration by flow cytometry

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U14-S04. Cytokine quantification assays (On-site&Remote) OUTSTANDING

Cytokine quantification assays

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U14-S03. Biomecanic evaluation of plantar pressure in large animal models (On-site) OUTSTANDING

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U13-S08. ATOMIC FORCE MICROSCOPY IDENTATION TEST (On-site) OUTSTANDING

ATOMIC FORCE MICROSCOPY IDENTATION TEST

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U19-S01. Preclinical in vivo toxicology (Onsite&Remote) OUTSTANDING

Preclinical regulatory in vivo toxicity, local and systemic tolerance and PK/PD studies; dosing of test and specimen drawing, biocompatibility studies of medical devices; Molecular biology techniques; Cell culture techniques; Flow cytometry; Safety studies: Nervous, cardiovascular and respiratory systems.

Security testing of advanced therapies using small and large animals models.

Sample preparation, inclusion, section and staining for preclinical histology (paraffin and frozen samples) as well as anatomopathological evaluation.

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U18-S01. In vitro Nanotoxicology (Remote) OUTSTANDING

Assays of cell viability/toxicity by XTT, release of LDH and similar indicators.

  • Study of toxicity in normal human cells immortalized by viral infection or tTERT, by means of metabolic XTT test,
  • Production of reactive oxygen species (ROS ) by fluorimetry.

Internalization assays

  • Study of the mechanism of toxic action
  • Analysis of hemocompatibility in blood
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U18-S02. In vivo Nanotoxicology, preclinical histopathology in animal models (Remote) OUTSTANDING

Sample preparation, inclusion, section and staining for preclinical histology (paraffin and frozen samples) as well as anatomopathological evaluation.

Complete necropsy:

  • Hematology
  • ADME/Tox of nanoparticles
  • Study of distribution of markers of interest by immunohistochemistry.
  • Study of the mechanism of toxic action (apoptosis, caspase-independent death, autophagia, necrosis).
  • Preclinical toxicity assays in animal models.

Product characterization studies, solubility and other properties studies; Inmunoassay techniques; Molecular biology techniques; Cell culture techniques; Flow cytometry; Safety studies: Nervous, cardiovascular and respiratory systems; Toxicology studies; PK/PD studies, Security testing of advanced therapies using small and large animals models.

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U18-S03.  In vivo TOXICOLOGY (Onsite&Remote) OUTSTANDING

Complete necropsy:

  • Hematology
  • ADME/Tox of nanoparticles
  • Study of distribution of markers of interest by immunohistochemistry.
  • Study of the mechanism of toxic action (apoptosis, caspase-independent death, autophagia, necrosis).
  • Preclinical toxicity assays in animal models
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