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Preclinical validation tissue, biomaterialls and surfaces characterization -Services

Preclinical validation tissue, biomaterialls and surfaces characterization -Services

U13-S8. ATOMIC FORCE MICROSCOPY IDENTATION TEST (On-site) OUTSTANDING

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U19-S01. Preclinical in vivo toxicology (Onsite&Remote) OUTSTANDING

Preclinical regulatory in vivo toxicity, local and systemic tolerance and PK/PD studies; dosing of test and specimen drawing, biocompatibility studies of medical devices; Molecular biology techniques; Cell culture techniques; Flow cytometry; Safety studies: Nervous, cardiovascular and respiratory systems.

Security testing of advanced therapies using small and large animals models.

Sample preparation, inclusion, section and staining for preclinical histology (paraffin and frozen samples) as well as anatomopathological evaluation.

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U18-S01. In vitro Nanotoxicology (Remote) OUTSTANDING

Assays of cell viability/toxicity by XTT, release of LDH and similar indicators.

  • Study of toxicity in normal human cells immortalized by viral infection or tTERT, by means of metabolic XTT test,
  • Production of reactive oxygen species (ROS ) by fluorimetry.

Internalization assays

  • Study of the mechanism of toxic action
  • Analysis of hemocompatibility in blood
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U18-S02. In vivo Nanotoxicology, preclinical histopathology in animal models (Remote) OUTSTANDING

Sample preparation, inclusion, section and staining for preclinical histology (paraffin and frozen samples) as well as anatomopathological evaluation.

Complete necropsy:

  • Hematology
  • ADME/Tox of nanoparticles
  • Study of distribution of markers of interest by immunohistochemistry.
  • Study of the mechanism of toxic action (apoptosis, caspase-independent death, autophagia, necrosis).
  • Preclinical toxicity assays in animal models.

Product characterization studies, solubility and other properties studies; Inmunoassay techniques; Molecular biology techniques; Cell culture techniques; Flow cytometry; Safety studies: Nervous, cardiovascular and respiratory systems; Toxicology studies; PK/PD studies, Security testing of advanced therapies using small and large animals models.

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U18-S03.  In vivo TOXICOLOGY (Onsite&Remote) OUTSTANDING

Complete necropsy:

  • Hematology
  • ADME/Tox of nanoparticles
  • Study of distribution of markers of interest by immunohistochemistry.
  • Study of the mechanism of toxic action (apoptosis, caspase-independent death, autophagia, necrosis).
  • Preclinical toxicity assays in animal models
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U17-S01. Confiocal Microscopy Service (Onsite) OUTSTANDING

Spectral confocal module coupled to an inverted microscope (4 objectives: 10x, 20x, 40x and 63x) equipped with three channels of spectral detection, AOBS (“Acousto-optical beam splitter”) and resonant scanner system. Argón, He/Ne and UV lasers. Incubation cabin for cells, which allows tracking of real-time processes.

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U16-S01. XPS (Remote) OUTSTANDING

Use of the system . X-ray photoelectron spectroscopy to measure quantitative elemental composition of surfaces (%) (except H and He).

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U16-S02. Ellipsometry (Remote) OUTSTANDING

Use of the system to measure the thickness of layers, and the composition, porosity and roughness of materials on a surface.

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U16-S03. Calorimetry (Remote) OUTSTANDING

Tests in real time to measure:
·· Molecule-molecule interactions: Protein-protein, Receptor-ligand, Antibody-antigen, Biomaterial-molecule interactions, Biomaterial-cell interactions.
·· Microbial growth.
·· Cell metabolism.
Experiments of stability, growth,
etc, perfusion and dilution

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U16-S04. Characterization by Tof-SIM (Remote) OUTSTANDING

Surface analysis of organic and inorganic materials (mass spectrum), map of chemical elements present in the surface of the sample (image), profile analysis shows sample analysis in depth.

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