Isolation and expansión of mesenchymal stem cells; viability assays and cytotoxicity, porcine mesenchymal stem cells (isolated from adipose tissue, bone marrow and synovial fluid) for preclinical trials. Murine mesenchymal stem (isolated from adipose and bone marrow).
X-Ray image for biomaterials, scaffolds and biological tissues.
Customer benefits
An axis inside is able to apply forces.
Non-destructive view of internal structure pre and post force.
Target customer
Public and private research groups focused on biomaterials and tissue mechanical characterization.
Additional information
Fatigue tests allow us to know how is the behaviour when cyclic load are applied. It is used for life expectancy of biomaterials and biological tissues.
Customer benefits
High full-scale cell load.
Target customer
Public and private research groups focused on biomaterials and tissue mechanical characterization.
Additional information
Dynamic tests allow us to know how is the behaviour along time. It is used for viscoelastic properties of biomaterials and biological tissues.
Customer benefits
High full-scale cell load.
Target customer
Public and private research groups focused on biomaterials and tissue mechanical characterization.
Additional information
Tensile, pure shear and planar tension are the tests inside the uniaxial group. Samples are stretched along an axis by measuring force and displacement. Cycling protocols can be integrated into the mechanical test. Mechanical and viscoelastic properties can be studied. Force is measured by means of load cells.
Customer benefits
Target customer
Public and private research groups focused on biomaterials and tissue mechanical characterization.
References
Additional information
Samples are compressed along an axis by measuring force and displacement. Cycling protocols can be integrated into the mechanical test. Mechanical and viscoelastic properties can be studied. Force is measured by means of load cells.
Customer benefits
Target customer
Public and private research groups focused on biomaterials and tissue mechanical characterization.
References
I. Cabeza-Gil, I. Ríos-Ruiz, B. Calvo, Experimental evaluation of the injection force exerted in intraocular lens delivery with syringe-type injectors,
Journal of the Mechanical Behavior of Biomedical Materials, 124, 2021, 104793, ISSN 1751-6161, Doi: 10.1016/j.jmbbm.2021.104793.
Additional information
For determination of size distribution in the 1-1000 nm range, we offer a Photon Correlation Spectrometer (PCS) for dynamic (DLS) and static (SLS) light scattering measurements for angles in the 20-140º range and capacity of suppressing multiple scattering thanks to the 3D-cross correlation technology (down to 5% of transmission for sub-micrometer sample thickness). The instrument is equipped with a He-Ne laser and its software allows the estimation of particle size by Cumulant or CONTIN analysis. It is also possible to measure non-ergodic samples with a rotating sample holder.
For determination of size distribution in the 100-10,000 nm range we offer a Mastersizer 2000 instrument that measures by means of laser diffraction the size and distribution of particles or droplets in suspension. It is equipped with a liquid dispersing unit for small volume (Hydro 2000G) to measure emulsions, dispersions, etc. and a solid dispersion unit (Scirocco) to analyse dried powders. It is equipped with a software (windows operated) for the data processing to obtain the characteristic size (droplet, particle) and its distribution.
Customer benefits
The services provided by the unit are very relevant for product formulation and quality control. Applications include determination of the droplet/particle diameter for emulsions, suspensions and solid samples (powder) in the range of 100 nm – 2000 mm. The results are expressed in standard percentiles D(v,0.1), D(v0.5), D(v0.9), mean volume diameter (D[4,3]), mean surface diameter (Sauter mean diameter, D[3,2]), specific surface area (SSA), etc.
Target customer
Public research organisations, academia and industry in the pharmaceutical, chemical, food and cosmetic sectors.
Additional information
More information can be found at https://www2.iqac.csic.es/qci/
For this service, we offer a S3 MICRO instrument (Hecus X-ray Systems, Graz, Austria) for determinations of X-ray scattered intensity as a function of scattering angle. This instrument is equipped with a GENIX microfocus X-ray source and a FOX 2D point-focusing element (both from Xenocs, Grenoble). It can measure simultaneously at small angle (0,2º-8º) and wide angle (18°-28°).
We also offer a Quantachrome Autosorb iQ-AG equipment that provides gas adsorption/desorption curves, for the calculation of specific surface area and pore size analysis. This equipment allows the simultaneous degassing of two samples and the physisorption analysis of a third sample, at relative pressures above P/P0 > 1×10-3. The gas sorption analyzer is equipped with a cryogenic dewar for measurements until 90 hours.
Customer benefits
The services provided by the unit are very relevant for product formulation and quality control. Applications include structural characterization of materials within the nanometer range. This includes determination of symmetry, morphology, characteristic size, fractal dimension and surface area. These studies can be applied to liquid crystals, micellar aggregates, mesoporous materials, nanoparticles, proteins and nanostructured films. Also characterization of the porosity and surface area of nanoparticles, macroporous, macro/mesoporous and mesoporous materials like aluminas, silicas and other materials including M41S materials (eg. MCM-41), PMOs, KITs and many SBAs.
Target customer
Public research organizations, academia and industry in the pharmaceutical, chemical, food and cosmetic sectors.
Additional information
More information can be found at https://www2.iqac.csic.es/qci/
This is an integrated service in which we offer the determination of the phase behaviour (e.g. as a function of temperature and concentration) of surfactants and polymers using different characterization techniques such as SAXS and polarized optical microscopy.
Customer benefits
The services provided by the unit are very relevant for product formulation and quality control.
Target customer
Public research organizations, academia and industry in the pharmaceutical, chemical, food and cosmetic sectors.
Additional information
More information can be found at https://www2.iqac.csic.es/qci/
For this service we offer a AR-G2 Rheometer with magnetic bearings which allows measuring torques down to 0.003 N.m. It can perform either stress controlled or strain controlled measurements. The angular velocity range is 2×10-7 to 628 rad/s. The maximum measurable torque is 200 mN.m, with a resolution of 0.1 nN.m. Several geometries are available, such as concentric cylinders, cone-plate, plate-plate (different sizes) and also cross hatched plates which are suitable to measure gel samples. Temperature is controlled with a Peltier system (from -20ºC to 200ºC) and with a Upper heating plate device. There is also an interfacial rheometry accessory. The instrument’s software enables to perform a wide variety of tests and analyses.
For standard tests we also offer a Brookfield viscometer with a wide measurement range from 25 mPa.s to 64 MmPa.s. It is equipped with an accessory (Small Sample Adaptor SSA) for samples of small volume (7-13.5 mL).
Customer benefits
The services provided by the unit are very relevant for product formulation and quality control. Applications include determination of viscosities from flow curves (stress vs shear rate); estimation of storage (elastic) modulus and loss (viscous) modulus, creep assays, temperature ramps; Determination of gel and glass points; Estimation of interfacial viscosity and moduli.
Target customer
Public research organizations, academia and industry in the pharmaceutical, chemical, food and cosmetic sectors.
Additional information
For further details on Rheology, click on the following poster:
More information can be found at https://www2.iqac.csic.es/qci/
