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U1. Protein Production Platform Unit (PPP)

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U1. Protein Production Platform (PPP)

U1. PPP logo IBB UAB

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Description

The PPP Unit is at the Institute of Biotechnology and biomedicine of the Autonomous University of Barcelona (IBB-UAB) and counts with the necessary facilities for the design, production and purification of recombinant proteins. This facility is coordinated by the Nanobiotechnology Group, leaded by Prof. Antonio Villaverde. It has both highly specialized personnel and the necessary equipment to offer an “tailored” service for the design, production and purification of recombinant proteins using both prokaryotic and eukaryotic expression systems. Its location allows this service to be linked with other complementary services available within the university (Cell Culture, Cytometry, Production of Antibodies, Microscopy, Proteomic, and Bioinformatic,X-ray crystallography, and the Microarray and Sequencing Services), as well as facilitating the management of subsequent uses of the produced protein.

Counts with a laboratory perfectly equipped for the bioproduction of proteins, other with all the necessary equipment for the molecular cloning, plus one lab for the purification and characterization, and finally one for cryopreservation.

The PPP Unit is also applying for the ISO9001 certification forstandard quality control system.

Publications

2016

  • Corchero J.L.. Eukaryotic aggresomes: from a model of conformational diseases to an emerging type of immobilized biocatalyzers. Applied Microbiology and Biotechnology. 2016;100(2):559-569.
  • Saccardo P., Corchero J.L., Ferrer-Miralles N.. Tools to cope with difficult-to-express proteins. Applied Microbiology and Biotechnology. 2016;:1-9.
  • Torrealba D., Seras-Franzoso J., Mamat U., Wilke K., Villaverde A., Roher N. et al. Complex particulate biomaterials as immunostimulant-delivery platforms. PLoS ONE. 2016;11(10)
  • Cano-Garrido O., Sanchez-Chardi A., Pares S., Giro I., Tatkiewicz W.I., Ferrer-Miralles N. et al. Functional protein-based nanomaterial produced in microorganisms recognized as safe: A new platform for biotechnology. Acta Biomaterialia. 2016;43:230-239.
  • Serna N., Cespedes M.V., Saccardo P., Xu Z., Unzueta U., Alamo P. et al. Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine. 2016;12(5):1241-1251.
  • Rueda F., Gasser B., Sanchez-Chardi A., Roldan M., Villegas S., Puxbaum V. et al. Functional inclusion bodies produced in the yeast Pichia pastoris. Microbial Cell Factories. 2016;15(1)
  • Cabrera I., Abasolo I., Corchero J.L., Elizondo E., Gil P.R., Moreno E. et al. α-Galactosidase-A Loaded-Nanoliposomes with Enhanced Enzymatic Activity and Intracellular Penetration. Advanced Healthcare Materials. 2016;5(7):829-840.
  • Céspedes MV, Unzueta U, Álamo P, Gallardo A, Sala R, Casanova I et al. Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4+ colorectal cancer models.Nanomedicine : nanotechnology, biology, and medicine. 2016;12(7)
  • Giannotti M.I., Abasolo I., Oliva M., Andrade F., Garcia-Aranda N., Melgarejo M. et al. Highly Versatile Polyelectrolyte Complexes for Improving the Enzyme Replacement Therapy of Lysosomal Storage Disorders. ACS Applied Materials and Interfaces. 2016;8(39):25741-25752.

News U1

06 Aug

How to optimize strategies to produce recombinant proteins?

Researchers of NANBIOSIS  U1. Protein Production Platform (PPP), organize a course on production of recombinant proteins together with  Aula Científica whose objective is to analyze and design strategies for the improvement in the expression, production and purification of recombinant proteins in heterologous systems. For  further information[...]

24 Jul

The general consul of France meets with NANBIOSIS researchers

The general consul of France in Barcelona, ​​Mr. Cyril Piquemal visited the IBB UAB facilities last July 18, to find out about the research that is being carried out and, in particular, explore possible collaborations in nano-pharmacy development projects. During the visit, the Consul of France in Barcelona was received by Màrius Martínez, Vice President of International Relations at the UAB; Maite Paramio, Deputy Vice President; Ivan Martínez, vice president of Research; Salvador Ventura, director of the Institute of Biotechnology and Biomedicine, and Antonio Villaverde, head of the IBB Nanotechnology Unit-NANBIOSIS  U1. Protein Production Platform (PPP) Next, the mayor visited[...]

22 Jul

Nanomedicine to fight against the spread of cancer

Nanoligent, S.L., the company stablished on March 2017 by professors Dr. A. Villaverde and Dra. E. Vázquez from NANBIOSIS Unit 1, professor Dr. M. Mangués from NANBIOSIS Unit 18, and entrepreneur Dr. M. Rodríguez is highlighted in la Vanguardia. More information here &nbs[...]

02 Jul

Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin

Researchers of NANBIOSIS Unit 1 and NANBIOSIS Unit 18, led by Prof Antoni Villaverde have published the article “Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin” at SMALL journal. Under the unmet need of efficient tumor‐targeting drugs for oncology, a recombinant version of the plant toxin ricin (the modular protein T22‐mRTA‐H6) is engineered to self‐assemble as protein‐only, CXCR4‐targeted nanoparticles. The soluble version of the construct self‐organizes as regular 11 nm planar entities that are highly cytotoxic in cultured CXCR4+ cancer cells upon short time exposure, with a determined IC50 in the nanomolar order of magnitude. T[...]

30 Jun

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs

Scientists of NANBIOSIS  Units U1. Protein Production Platform (PPP),  and U18. Nanotoxicology Unit, have recently published an article titlled “Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs” in the Journal of  Controlled Release. Loading capacity and drug leakage from vehicles during circulation in blood is a major concern when developing nanoparticle-based cell-targeted cytotoxics. To circumvent this potential issue it would be convenient the engineering of drugs as self-delivered nanoscale entities, devoid of any heterologous carriers. In this context, we have here engineered potent protein toxins, namely segments of the diphtheria toxin and the Pseudomonas aeruginosa exotoxin as self-assembling, self-delivered therapeutic materials targeted to CXCR4+ cancer stem cells. The systemic administration of both nanostructured drugs in a[...]

28 Jun

Release of targeted protein nanoparticles from functional bacterial amyloids: A death star-like approach

Sustained release of drug delivery systems (DDS) has the capacity to increase cancer treatment efficiency in terms of drug dosage reduction and subsequent decrease of deleterious side effects. In this regard, many biomaterials are being investigated but none offers morphometric and functional plasticity and versatility comparable to protein-based nanoparticles (pNPs). Researchers of NANBIOSIS units 1 and 18 are co-authors of an article  publish by Journal of Controlled Release in which it is described a new DDS by which pNPs are fabricated as bacterial inclusion bodies (IB), that can be easily isolated, subcutaneously injected and used as reservoirs for the sustained release of targeted pNPs. Our approach combines t[...]

26 Jun

Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides

Scientists of Units 1 and 18 of NANBIOSIS are coathors of the article  “Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides” published by Nanomedicine: Nanotechnology, Biology and Medicine Arginine-rich protein motifs have been described as potent cell-penetrating peptides (CPPs) but also as rather specific ligands of the cell surface chemokine receptor CXCR4, involved in the infection by the human immunodeficiency virus (HIV). Polyarginines are commonly used to functionalize nanoscale vehicles for gene therapy and drug delivery, aimed to enhance cell penetrability of the therapeutic cargo. However, under which conditions these peptides do act as either unspecific or specific ligands is unknown. The authors have here explored the cell penetrability[...]

26 Jun

Nanoligent obtains the first prize in the Tech Transfer Competition in the ONCO Emergence forum

Last June 21-22th, took place at the Fira Gran Via in Barcelona, the ONCO Emergence forum, a networking conference focused on setting up transnational collaboration projects in oncology by promoting interaction among research institutes, companies and medical facilities like hospitals. In other to promote alliances and generate collaborative projects from hospitals and academia to other stakeholders, ONCO Emergence Forum Barcelona has created a  Tech Transfer Competition that features cherry-picked entrepreneurs, TTO or principal investigators developing new technology ready to be licensed or in development through a spin-off.  Selected participants presented their innovative projects in a 6-minute English pitch to an experienced[...]

U1-Protein Production Platform - PPP
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U5. Rapid Prototyping Unit

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U5. Rapid Prototyping Unit

  • Scientific Director: Prof. Elisabeth Engel elisabeth.engel@upc.edu
  • Scientific Coordinator: Miguel Angel Mateos mamateos@ibecbarcelona.eu
  • Entities: Biomaterials for Regenerative Therapies Group & Intitute of Bioengineering of Catalonia (IBEC)
  • Address: C/BaldiriReixac 15-21, 08028, Barcelona, Spain
  • Phone: +34 934 039 735
  • Web: IBEC

IBEC

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Description

This facility is headed by Dr. Elisabeth Engel, PI of the Biomaterials for Regenerative Therapies Group at the Institute for Bioengineering of Catalonia (IBEC) and counts with a laboratory equipped to produce 3D structures of different materials. This system allows the fabrication of 3D porous scaffolds of defined geometry and porosity for tissue engineering applications. Dispensing and locating cells in specific positions on defined substrates is also possible due to the high precision levels of this tool.

Services

 

FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE

U5. Services & Rates

News U5

10 Jul

Biomaterials as signal-releasing platforms

Scientists of the CIBER-BBN and IBEC reserch group Biomaterials for Regenerative Therapies, led by Miguel Angel Mateos-Timoneda and Elisabeth Engel who run NANBIOSIS U5. Rapid Prototyping Unit,  have  published a review of the state-of-the-art in biomaterials for skin healing that proposes a move towards more personalized, in situ therapies. Skin wound healing repairs and restore tissue through a complex process that involves different cells and signalling molecules that regulate cellular response and the remodelling of the extracellular matrix. Publishing in Advanced Drug Delivery Reviews, the article begins by summarizing recent advances in therapies for healing that combine biomolecule signals such as growth factors and cytokines wit[...]

19 Jun

Institutional impulse to accelerate 3D printing projects

Elisabeth Engel,  Scientific Director of Unit 5 of NANBIOSIS, U5. Rapid Prototyping Unit, will led the research project, QuirofAM, to produce biodegradable and bioactive scaffolds printed in 3D as osteochondral and maxillofacial substitutes. This is one of the projects to be promoted by LLAVOR 3D Community, an association of Catalan entities, created last month, which includes the IBEC (housing units 5 and 7 of NANBIOSIS). LLAVOR 3D Community aims to accelerate the development and adoption of additive manufacturing and 3D printing technologies by the industry. Within the projects of the LLAVOR 3D Community, new software tools, new materials, more efficient and versatile production[...]

06 Jun

A dressing with active ingredients to regenerate skin wounds

Elisabeth Engel, Scientific Director of NANBIOSIS U5, Rapid Prototyping Unit, is interviewed in “Deuwatts”, a programe of  Btv, devoted to biomedical engineering. Dr. Engel explains how  they have designed a dressing with active substances to regenerate skin wounds and talks about bio-printing for therapeutic models. Watch it here. &nbs[...]

23 Feb

NANBIOSIS ICTS invites groups and companies to discuss Smart Biomaterials and devices for Drug Delivery

On February 22nd, the National School of Health of the Carlos III Health Institute hosted the forum on Smart Biomaterials and biomedical devices for applications in drug delivery and regenerative medicine, organized by the ICTS Nanbiosis, an infrastructure shared by the CIBER-BBN and the Center of Minimally Invasive Surgery Jesus Usón (CCMIJU). This is the first groups/companies meeting organized by Nanbiosis, in which about 70 B2B meetings  were held. The meeting brought together about 40 participants from 14 research groups (from the CIBER-BBN and the CCMIJU) and 10 companies, which discussed the latest advances in the research lines developed by the groups[...]

28 Feb

3D printing biocompatible hydrogels

  Researchers of Unit 5 of NANBIOSIS, in collaboration with colleagues from the University of Montpellier, have laid the groundwork for faster advances in 3D printing for regenerative medicine by creating a system of ink and matrices that offers a solid basis for tissue regeneration. Due to their high water content, hydrogels are highly attractive biomaterials for 3D printing as efficient ‘surrogates’ for the extracellular matrix, onto which cells can be cultured. However, while they are relatively easy to produce using a method called extrusion printing, their stability and structural integrity can weaken when they’re in contact with biological fluids[...]

21 Dec

EIT Health Spain awards the best innovation and entrepreneurship projects
EIT Health Spain awards the best innovation and entrepreneurship projects

Elisabeth Engel, Scientific Director of Unit 5 of NANBIOSIS, has received an award at EIT Health Spain event held this month at the PCB, Barcelona.  The awards have been organized by the Spanish node during 2016 and are part of the financing initiatives of the EIT Health accelerator. Professor Engel participated in the category of ‘Proof of Concept (PoC)” that recognises projects and business ideas that are in stages prior to the creation of the company and projects that are participating in acceleration programs in health. Elisabeth won a prize funded with 25.000 € for Dermoglass, the smart dressing for[...]

13 Sep

Elisabeth Engel stimulating scientific talent in the Barcelona International Youth Science Challenge
Elisabeth Engel stimulating scientific talent in the Barcelona International Youth Science Challenge (BIYSC)

Dr. Engel, Scentific Director of Unit 5 of NANBIOSIS, participated in the Barcelona International Youth Science Challenge (BIYSC) held in Barcelona from July 11th to 22nd 2016. Ms. Elisabeth gave the lecture “Biomaterials beyond a simple template”, introducing the students to the breakthrough in the medical and social  field of obtaining a synthetic biomaterial that eludes the need of cell therapy or the application of morphogens and growth factors. The research group led by Elisabeth Engel hosted one of the projects of this programme: “Instructive Biomaterials for Regenerative Medicine” dealing with replacement or regeneration of human cells, tissues or organs,[...]

05 Jul

Elizabeth Engel, Scientific Coordinator of Unit 5 of NANBIOSIS: “Our research has opened the door to the regeneration of the nervous system by biomaterials”
Elizabeth Engel, Scientific Coordinator of Unit 5 of NANBIOSIS: “Our research has opened the door to the regeneration of the nervous system by biomaterials”

The CIBER-BBN research group Biomaterials for Regenerative Therapies, which coordinates Unit 5 of NANBIOSIS develops various lines of research on biomaterials for regenerative therapies, especially focusing on the design and fabrication of scaffolds for tissue regeneration. They are working with polymers, hydrogels and compounds that can be manufactured using different techniques such as electrospinning to make 3D printing matrices or scaffolding. Applications are diverse, such as bone regeneration, neuronal, skin or cell therapy. The group has recently presented the results of a project focused on the development of implants for the regeneration of nerve tissue with very promising results. T[...]

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U7. Nanotechnology Unit

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U7. Nanotechnology Unit

  • Scientific Director: Prof. Josep Samitier jsamitier@ub.edu
  • Scientific Coordinator: Dr. Isabel Oliveira ioliveira@ibecbarcelona.eu
  • Scientific Coordinator: Dr. Mateu Pla Roca mpla@ibecbarcelona.eu
  • Entities: Intitute of Bioengineering of Catalonia (IBEC)
  • Address: C/Baldiri I Reixac, 10, 08028, Barcelona, Spain
  • Phone: +34 934 037 138
  • Web: IBEC

IBEC

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Description

The Nanotechnology Platform is part of the institute’s long-term strategic plan to create new Core Facilities in nanofabrication and bionanocharacterization. Currently, the platform is an accessible and versatile research facility featuring 150m2 of class 10,000 cleanroom space and laboratories offering state-of-the-art equipment for the fabrication and characterization of micro- and nanodevices and structures. Our aim is to facilitate advanced research by providing services in the fields of nanoscience and nanotechnology for all academic and industrial researchers. Some of the many areas of application include nanobioengineering, BioMEMS, materials science, tissue engineering, optic and biomaterials. IBEC’s Nanotechnology Platform offers scientific and technological support that includes the design, development and analysis of devices, materials, and processes, so that academic researchers and companies alike may use the platform to develop their innovative ideas.

News U7

03 Aug

Nanopatterns of Surface-Bound EphrinB1 Produce Multivalent Ligand–Receptor Interactions That Tune EphB2 Receptor Clustering

Researchers  of NANBIOSIS U7. Nanotechnology Unit, are coauthors of the article “Nanopatterns of Surface-Bound EphrinB1 Produce Multivalent Ligand–Receptor Interactions That Tune EphB2 Receptor Clustering” published by NanoLetters, ACC Publications. The authors present a nanostructured surface able to produce multivalent interactions between surface-bound ephrinB1 ligands and membrane EphB2 receptors. They have created ephrinB1 nanopatterns of regular size (<30 nm in diameter) by using self-assembled diblock copolymers. Next, they have used a statistically enhanced version of the Number and Brightness technique, which can discriminate—with molecular sensitivity—the oligomeric states of diffusive species to quantitatively track the EphB2 receptor oligomerization process in real time. The results[...]

06 Jul

Josep Samitier, Scientific Director of NANBIOSIS Unit 7, Panelist in a round table about the current situation of biomedical research

Last month NANBIOSIS Unit 7 Nanotechnology Unit Scientific Director Josep Samitier was one of the panelists in a round table organised by the Cercle de Salut, an association devoted to improving the health system so that it may respond adequately to the challenges posed by society. In the discussion at the Parc de Recerca Biomèdica de Barcelona (PRBB) entitled ‘L’excel·lència en la recerca, reptes immediats’, Josep and the other participants – ISGlobal director Antoni Plasencia and IrsiCaixa director Bonaventura Clotet – discussed the current situation of biomedical research in Catalonia. In particular, the hot topic under discussion was the impact that recent[...]

04 Jul

«The combination of nanotechnology with bioengineering and biomedicine allows us to act on the human body on a molecular scale»

Josep Samitier, Scientific Director of NANBIOSIS Unit 7 Nanotechnology Unit, has been highlighted in ‘Dominical’ supplement of the Diari de Girona last week. More information here [...]

10 May

NANBIOSIS U7 Scientific Director, J Samitier and his vision on technology as a source of eternal youth

Josep Samitier, Scientific Director of U7 of NANBIOSIS, Nanotechnology Unit, has been recently featured in an article in the Jornal “El Mundo” Following the publication of the book “The Death of Death” by Jose Luis Cordeiro and David Wood, which says that by 2045 death will optional thanks to new technologies finding a way to cure aging, the article interviewed Josep Samitier, to have a more realistic point of view. The book ‘Death of death’ assures that in 2045 die will be something optional thanks to the new technologies will find a way to cure aging based on success examples[...]

20 Apr

Two Units of NANBIOSIS participates in the CIBERONC – CIBER-BBN collaboratives projects

Scientists from two NANBIOSIS units participate in two of the three projects selected in the Call CIBER-BBN / CIBERONC. On April 13, the 1st CIBERONC – CIBER-BBN Collaborative Projects Forum took place at the National School of Health (Carlos III Health Institute). The purpose of the event was to carry out the resolution of the call for collaborative seed projects between the two areas. During the forum, 12 proposals for collaborative projects were presented, encompassed in four thematic sessions: new nano-devices, new strategies for 3D culture, phototherapy and drug release. All the proposals included the application of some of t[...]

16 Nov

Posters presentation by NANBIOSIS Units in CIBER-BBN ANNUAL CONFERENCE 2017

Last 13 and 14 of November, CIBER-BBN  has celebrated its 11th Annual Conference in Hotel Santemar in Santander. In this conference there was a poster session with the participation of the following Units of NANBIOSIS. Special mention deserves Unit 1 with Neus Ferrer as Director and  Paolo Saccardo as Coordinator (in the picture): Posters: U1. Protein Production Platform (PPP): Engineering protein complexes as nano- or micro-structured vehicles or drugs for human and veterinary medicine. Ugutz Unzueta, Naroa Serna, Laura Sánchez-García, José Vicente Carratalá, Olivia Cano-Garrido, Mercedes Márquez, Paolo Saccardo, Rosa Mendoza, Raquel Díaz, Héctor, López-Laguna, Julieta Sánchez, Anna Obando, Amanda Muñoz, Andrés Cisneros, Eric Voltà, Aida Carreño, José[...]

13 Jul

3D bioprinting applied to cancer diagnostics

Mateu Pla Roca, Scientific Coordinator of Unit 7 of NANBIOSIS /IBEC Core Facilities has won CaixaImpulse funding for his project “3D bioprinted array tissue-like cores: tissue-like controls for cancer diagnostics” (3DBIOcores), which will be carried out in collaboration with Antoni Martinez, head of the histopathology service at Hospital Clinic. CaixaImpulse programme aims to promote technology transfer in science. The project 3DBIOcores will take advantage of 3D bioprinting to create quality control samples that assure and improve cancer diagnostics. Usually, diagnosis is done by histopathology – the microscopic examination of tissues – and then the biomarkers that are found are quantified. However,[...]

19 Dec

NANBIOSIS in three projects funded by CaixaIMPULSE.
NANBIOSIS in three projects funded by CaixaIMPULSE

La Caixa has just presented the twenty projects selected by CaixaImpulse in a call with more than 70 proposals from different research centres, hospitals and universities. CaixaImpulse is an initiative unique in Spain that aims to boost research in biotechnology and life sciences to develop projects that generate value in society. Among the selected projects there are two coordinated by NANBIOSIS researchers: Pseudomonas aeruginosa diagnosis led by Miriam Corredor Sánchez (Unit 2 of NANBIOSIS) and ISCHEMSURG, led by Monica Mir (Unit 7 of NANBIOSIS). In addition, the project ExoLiver, in which participates Rosa Villa and the research group coordinating Unit 8[...]

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U10. Drug Formulation

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U10. Drug Formulation

  • Scientific Director: Prof. José Luis Pedraz joseluis.pedraz@ehu.es
  • Scientific Coordinator: Dr. Jesús Ciriza Astrain jeciriza@gmail.com
  • Entities: Universidad del País Vasco (UPV/EHU)
  • Address: Pharmacy & Pharmac. Technology Lab.; Facultad de Farmacia, C/Paseo de la Universidad 7, 01006 Vitoria-Gasteiz (Spain)
  • Phone: +34 945 013091
  • Fax: +34 945 013040
  • Web: NANOBIOCEL UPV/EHU

UPV-EHU

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Description

Located at the Faculty of Pharmacy, University of the Basque Country (UPV), Campus of Vitoria, is led by Prof. José Luis Pedraz and consists of large laboratories for: cell culture, chromatography equipment, sample preparation and characterization and one specific for scale preparation of pharmaceutical formulations. This Unit has the capacity to design and evaluate dosage forms both classical and new dosage forms of biotech drugs, DNA, RNA and vaccines using different methodologies based on micro and nano-medicine. The latter methodology based on the microencapsulation of cells, peptides, proteins, and in general of biotech products, as well as the development and design of non-viral vectors for gene therapy, is one of the biggest singularities of this unit. It counts with the most advanced equipment for micro and nano encapsulation.

The aim of the Unit is to determine experimentally all the variables needed to develop an optimal formulation and work instructions for preparing final pharmaceutical products.

The pharmaceutical technology applied to drug development involves the selection of materials and procedures that can be adapted to different processes that lead to specific pharmaceutical forms. To do that, the Unit counts with the most advanced equipment to cover the development for all the steps of the process.

One of the singularities of this Units is that is GLP certified by the Spanish Medicament Agency

U10. Services & Rates

News U10

22 Jun

NANOMEDICINE APPLICATIONS IN DRUG DELIVERY AND TARGETING: NANBIOSIS – NANOMED Industrial Forum

Yesterday took place in Barcelona, at Barcelona School of Management, Universitat Pompeu Fabra, a meeting of resarch groups and units of NANBIOSIS and CIBER-BBN and companies in the third B2B Forum organized by NANBIOSIS, in this case together with NANOMED SPAIN. Thirteen companies and twelve groups from CIBER-BBN and CCMIJU (ten of them coordinating NANBIOSIS [...]

20 Jun

NANBIOSIS working on the development of next generation catheters

NANBIOSIS’ partners CIBER-BBN and JUMISC, with another 44 European partners, led by Philips Electronics Nederland B.V, will work on the development of next genration catheters.  The project, Position-II  (Ref. n. 783132), that pretends to diversify the production of smart catheters (overcoming the obsolescence of current ones), improve their performance (facilitating their use to be smaller), [...]

03 Jun

DRIVE Project: Artificial Biopancreas for Type I Diabetics

On Saturday, June 2, in the auditorium of the Artium museum in Vitoria, a meeting was held for patients with diabetes, organized by the group of European researchers of the DRIVE project with the aim of conecting patiens with researchers. The event was organized by the NanoBioCel research group of the CIBER-BBN and the University of [...]

28 May

New frontiers in the treatment of Diabetes type 1

On Saturday, June 2, at 10.30 in the auditorium of the Artium Museum in Vitoria-Gasteiz, a meeting will take place for patients with diabetes, organized by the group of European researchers of the DRIVE project. The objective of the meeting, held for the first time in Spain, is to connect researchers with all those with [...]

15 May

Nanotechnology, gene therapy, omics therapies and ‘big data’

Nanotechnology, gene therapy, omics therapies and ‘big data’ were the topics discussed in the Forum on Emerging Technologies oganized on May 8 by nanotechnology, gene therapy, omics therapies and ‘big data’ were the topics discussed in the I Forum on Emerging Technologies held on May 8, organized by the CIBER Internationalization Platform, of which the CIBERER, [...]

05 May

Gene therapy in pseudohypoparathyroidism

In 1942, Albright and colleagues described the first hormone resistance syndrome, which they called pseudohypoparathyroidism (PHP) (1), patients had a specific phenotype consisting of short stature, central obesity, round face, short neck and brachydactyly, which is what that today we know like Albright Hereditary Osteodystrophy (AHO, Albright Hereditary Osteodystrophy). Nanobiocel research group, coordinator of NANBIOSIS U10. [...]

30 Apr

I Forum on Emerging Technologies organized by CIBER

On May 8th, will take place in Madrid, at the Assembly Hall Ernest Lluch of the Instituto de Salud Carlos III, organized by CIBER Internationalization Platform (CIBER-BBN, CIBERER, CIBERES) the I Forum on Emerging Technologies. The objective of this meeting is to promote the exchange of ideas and scientific knowledge among the CIBER research groups with the [...]

02 Mar

NANBIOSIS Unit 10 of Drug Formulation participates in the European Project Position II

Nanobiocel, the CIBER-BNN – UPV-EHU group, led by José Luis Pedraz, Scientific Director of NANBIOSIS-ICTS U10 “Drug Formulation Unit” participates in the Position II European project, coordinated by Philips Electronics Nederland. The project, funded through the Horizon 2020 call with a global budget of more than 50 million euros, will be developed during three years [...]

23 Feb

NANBIOSIS ICTS invites groups and companies to discuss Smart Biomaterials and devices for Drug Delivery

On February 22nd, the National School of Health of the Carlos III Health Institute hosted the forum on Smart Biomaterials and biomedical devices for applications in drug delivery and regenerative medicine, organized by the ICTS Nanbiosis, an infrastructure shared by the CIBER-BBN and the Center of Minimally Invasive Surgery Jesus Usón (CCMIJU). This is the [...]

25 Jan

Cryopreservation of stem cells

Scientific Reports of the Nature Publications Group has recently published the article ‘Cryopreservation of human mesenchymal stem cells in an allogeneic bioscaffold based on platelet rich plasma and synovial fluid’. This research is part of the doctoral thesis of Haritz Gurruchaga, belonging to the NanoBioCel group of CIBER-BBN and UPV / EHU, which is focused [...]

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U13. Tissue & Scaffold Characterization Unit

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U13. Tissue & Scaffold Characterization Unit

  • Scientific Director: Prof. Miguel Angel Martínez miguelam@unizar.es
  • Scientific Coordinator: Fany Peña fany@uniza.es
  • Entities: Universidad de Zaragoza. Departamento de Ingeniería Mecánica.
  • Address: Campus Río Ebro. Edificio I D I. C/ María de Luna, S/N, 50018 Zaragoza, Spain
  • Phone: 34 976 761 000 ext 5233 / 34 976 761 912
  • Web: I3A-UZ
Nanabiosis-logo Universidad de Zarargoza-U9-U13-U27.
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Description

This platform is coordinated by Dr. E. Peña member of the Applied Mechanics and Bioengineering Group of the Aragón Institute of Engineering Research (I3A) at the University of Zaragoza. The objective of this unit is to provide services for structural and physical characterization of biological tissues and tissue scaffolding, including microstructure, histology and mechanical tests among others. This platform, unique in Spain as regarding its capability, has a clear and direct translational impact, especially in regenerative medicine, implant design and evaluation, as well as in the study of the mechanical behavior of living tissues (especially in the musculoskeletal and cardiovascular systems). Its relationship with the Instituto Aragonés de Ciencias de la Salud (Health Sciences Institute of Aragon), and through it with the Tissue and Blood Bank of Aragon and with the School of Veterinary Science at the Universidad de Zaragoza, allows an easy provision of tissues both from animals (mice, rabbit, sheep, pig) and humans, following in their handling the recommendations of the different ethics committees.

It has several types of INSTRON testing machines specializedin biological tissues, for the characterizationof soft tissues and fibers, as well as an X-ray microCT which allows quantitatively characterizing the microstructure of in vitro samples of hard tissues and of biomaterials for scaffolds. It also has the entire system necessary for performing high-quality histologies which would complete the structural characterization of the previously cited types of tissues (staining of preparations, immunohistochemistry in paraffin with EnVision, laser microdissection, etc.). As additional tests, equipment for determining the permeability of biological tissues and scaffolds under culture conditions, monitoring their variation over time is also available. Finally, the platform is also composed of different types of bioreactors, including perfusion or direct compression on seeded scaffolds for stimulating cell cultures for tissue engineering applications.

News U13

17 Jul

NANBIOSIS researcher Iñaki Ochoa, interviewed in the Heraldo de Aragón criticizes the administrative obstacles to science imposed by law.

Scientists of NANBIOSIS in the University of Zaragoza participated in the assembly held las week that put on the table the risks of applying rules in an incoherent way and without taking into account the reality of the work that researchers develop. The Spanish public contrat law prevents the University to spend more than 15,000 euros per provider per year, which complicates the purchases of material. The scientists ask that this legislation not be applied More than three hundred researchers  have signed a manifesto in which they denounce that some provisions of the new Spanish law on public contracts prevent them[...]

13 Jul

Manuel Doblaré, Unit 13 of NANBIOSIS, SEMNI Award O. C. Zienkiewicz

The Spanish Society of Numerical Methods in Engineering (SEMNI) has awarded the SEMNI O. C. Zienkiewicz prize to Professor Dr. Manuel Doblaré. The SEMNI O. C. Zienkiewicz Award is the highest award given by this company and recognizes, in this case, both the undisputed scientific curriculum of prof. Doblaré as his permanent contribution to the good functioning of this society, of which he has been a founding member and member of its executive committee until 2007, having also organized the Congress of Numerical Methods in Zaragoza in 1996. The prize will be given during the Congress of Numerical Methods to[...]

09 Jun

SINO-SPAIN Biomedical and Pharmaceutical Conference with NANBIOSIS participation

Last 7 June 2018 took place in Zaragoza, the Sino-Spain Biomedical and Pharmaceutical Conference, as a result of years of cooperation with Chinese institutions, organizad by Zaragoza University  and Aragonese Foundation for Research & Development of Aragon Government (ARAID), to promote initiatives and foster bilateral collaboration in biomedical and pharmaceutical sectors between Spain and China. The themes of the forum were: Molecular engineering for biomedical products Diagnoses &Design for new devices for medical uses Tissue Engineering and regenerative medicine Pharmacology and nanometerials for medical application Advanced therapies for cancer research   Researcher of three units of NANBIOSIS partcipated in the Conference: from U13. Tissue &am[...]

29 May

NANBIOSIS participation at VII Conference of Young Researchers of I3A

The I3A organizes the VII Conference of Young Researchers to be held on June 2, 2018. As in past editions, the Confernce will be addressed to all those who are doing the doctoral thesis whose director or co-director is a member of I3A. Scientists of  NANBIOSIS Unit 13 Tissue & Scaffold Characterization Unit will participate with the following poster: Personalized simulation of intraestromal ring insertion surgery (ICRS). Validation with clinical data. Julio Flecha, Miguel Ángel Ariza-Gracia, Jesús Zurita, Begoña Calvo Simulation of cell populations in Organ-On-Chip devices: of the models classics to data driven simulations. Jacobo Ayensa-Jiménez, Marina Pérez Aliacar, Teodora Randelovic, Sara Oliván, Iñaki Ochoa,[...]

04 May

Microfluidic technologies to study the cardiomyopathy processes of Duchenne’s disease

Ignacio Ochoa and Luis Fernandez, researchers of the AMB group of CIBER-BBN and I3A-University of Zaragoza, coordinator of NANBIOSIS U13. Tissue & Scaffold Characterization Unit, are working on the european project “CISTEM – HEART ON CHIP BASED ON INDUCED PLURIPOTENT STEM CELL TECHNOLOGY FOR PERSONALIZED MEDICINE” . They are developing heart on a chip microfluidic devices to study the cardiomyopathy process in the Duchenne muscular distrophy using microfluidic technologies. CISTEM Kick-off Meeting was successfully held on 24th of January 2018 at Elvesys, Paris, France. Representative of the consortium organizations including academic institutions and industry representatives were participating in this meeting: BioSense Institute, Elvesys,[...]

07 Mar

Numerical models applied to the cornea to improve eye surgery

Researchers of the NANBIOSIS U13 apply numerical models to the cornea to better understand how it behaves and help in surgical planning. Data and algorithms developed through the computer, together with the 3D image, make it easier for ophthalmologists to perform eye surgery more precise and personalized treatments for each patient The work carried out by Miguel Ángel Ariza Gracia at the Aragón Engineering Research Institute (I3A) has been recognized by the University of Zaragoza with the Extraordinary Award for the Best Doctoral Thesis of the Biomedical Engineering Program in 2017 In this line of research, framed in the European[...]

23 Feb

NANBIOSIS ICTS invites groups and companies to discuss Smart Biomaterials and devices for Drug Delivery

On February 22nd, the National School of Health of the Carlos III Health Institute hosted the forum on Smart Biomaterials and biomedical devices for applications in drug delivery and regenerative medicine, organized by the ICTS Nanbiosis, an infrastructure shared by the CIBER-BBN and the Center of Minimally Invasive Surgery Jesus Usón (CCMIJU). This is the first groups/companies meeting organized by Nanbiosis, in which about 70 B2B meetings  were held. The meeting brought together about 40 participants from 14 research groups (from the CIBER-BBN and the CCMIJU) and 10 companies, which discussed the latest advances in the research lines developed by the groups[...]

17 Nov

Unit 13 of NANBIOSIS participates in a new European project that will boost the Organ-on-Chip technology

The research group coordinating NANBIOSIS Unit 13 is the Spanish group of the European project ORCHID (Organ-On-Chip In Development). The scientists  of Engineering Research Institute (I3A) and CIBER-BBN, Luis Fernández and Iñaki Ochoa, will work on this project whose objective is to accelerate the social and economic impact of the technology known as Organ-on-Chip. This technology based on the use of microfluidic platforms is already facilitating the discovery of drugs, but it can go a step further with applications in personalized medicine and safety pharmacology and that, in addition, offers alternatives to conventional tests in animals. The mechanical properties and[...]

U13-Tissue & Scaffold Characterization Unit
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U16. Surface Characterization and Calorimetry Unit

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U16. Surface Characterization and Calorimetry Unit

  • Scientific Director: Prof. M Luisa González Martín mlglez@unex.es
  • Scientific Coordinator: Prof. M Luisa González Martín mlglez@unex.es
  • Entities: Universidad de Extremadura
  • Address: Avda Elvas, S/N, 06006, Badajoz, Spain
  • Phone: +34 924 289 532
  • Web: WEB

UEX

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Description

 

The purpose of this Unit is to give support for the analysis of surface composition to researchers. This facility allows a broad knowledge about the chemistry of surfaces by the combination of the information of elements presents and their coordination state, given by the XPS technique, and the molecular structure of surface provided by the ToF-SIMs equipment. Its capabilities permit to work with extended and powdered solids, including those from biological origin as cells and bacteria. The characteristics of thin films on surfaces, as thickness, composition or electrical conductivity, can be also analyzed in this unit by spectroscopic ellipsometry. In addition, calorimetric analysis can be performed to test surface reactivity on powdered solids. ITC calorimetry facility is also under the Unit scheme.

Surface analysis laboratory fulfils the ISO9001:2008 (ES050823-1).  Nanbiosis- U16-logo-ISO9001

News U16

23 Feb

NANBIOSIS ICTS invites groups and companies to discuss Smart Biomaterials and devices for Drug Delivery

On February 22nd, the National School of Health of the Carlos III Health Institute hosted the forum on Smart Biomaterials and biomedical devices for applications in drug delivery and regenerative medicine, organized by the ICTS Nanbiosis, an infrastructure shared by the CIBER-BBN and the Center of Minimally Invasive Surgery Jesus Usón (CCMIJU). This is the first groups/companies meeting organized by Nanbiosis, in which about 70 B2B meetings  were held. The meeting brought together about 40 participants from 14 research groups (from the CIBER-BBN and the CCMIJU) and 10 companies, which discussed the latest advances in the research lines developed by the groups[...]

16 Nov

Posters presentation by NANBIOSIS Units in CIBER-BBN ANNUAL CONFERENCE 2017

Last 13 and 14 of November, CIBER-BBN  has celebrated its 11th Annual Conference in Hotel Santemar in Santander. In this conference there was a poster session with the participation of the following Units of NANBIOSIS. Special mention deserves Unit 1 with Neus Ferrer as Director and  Paolo Saccardo as Coordinator (in the picture): Posters: U1. Protein Production Platform (PPP): Engineering protein complexes as nano- or micro-structured vehicles or drugs for human and veterinary medicine. Ugutz Unzueta, Naroa Serna, Laura Sánchez-García, José Vicente Carratalá, Olivia Cano-Garrido, Mercedes Márquez, Paolo Saccardo, Rosa Mendoza, Raquel Díaz, Héctor, López-Laguna, Julieta Sánchez, Anna Obando, Amanda Muñoz, Andrés Cisneros, Eric Voltà, Aida Carreño, José[...]

19 Dec

Biomedical materials that repel bacteria
Biomedical materials that repel bacteria

The magazine Viceversa dedicates a special article to María Luisa González, Professor of Applied Physics at the University of Extremadura and Scientific Director of Unit 16 of NANBIOSIS: Surface Characterization and Calorimetry Unit. One of her latest projects, PHYTECH, has developed a new surface for bone implants containing phytate, a natural product found in plant seeds that favours the regeneration of bone tissue and reduces the risk of infections in implants. Now, her research group is about to start a new European project with implant manufacturers in Austria and Lithuania, whose goal is to obtain a crystalline coating for titanium[...]

06 May

U16. Ellipsometer
A new surface for bone implants that promotes regeneration and reduces the risk of infections in which.

The Phytech project (funded by the Spanish Government through the Call INNPACTO) has recently finished with the participation of CIBER-BBN, through Unit 16 of NANBIOSIS, the University of the Balearic Islands and the companies NuMat Biomedical and Sanifit). Unit 16 of NANBIOSIS – Surface Characterization and Calorimetry, coordinated by Dr. M. Luisa Gonzalez, has conducted tests of surface composition by surface characterization techniques (XPS and ToF-SIMS) as well as the analysis microbial response of the raised surfaces in this development The results of this project have been published in the journal Applied Materials & Interfaces of the American Chemical Society.[...]

U16-Surface Characterization and Calorimetry Unit
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U17. Confocal Microscopy Service

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U17. Confocal Microscopy Service

  • Scientific Director: Prof. Juan Manuel Bellón juanm.bellon@uah.es
  • Scientific Coordinator: Gemma Pascual gemma.pascual@uah.es
  • Technical Coordinator: Mª Isabel Trabado unidad.cultivos@uah.es
  • Entities: Cell Culture Unit. Modulo IV, Planta Baja. Facultad de Medicina Universidad de Alcalá (UAH)
  • Address: Ctra. Madrid-Barcelona, km. 33,6, 28871, Alcalá de Henares, Madrid, Spain
  • Phone: +34 918 854 535
  • Web: WEB

UAH

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Description

Located in the Cell Culture Unit, Faculty of Medicine, University of Alcalá, has a room perfectly suited to host a Confocal Microscope service that provides 4 lasers and cell incubation cabin. This Unit is coordinated by Dr. Juan Manuel Bellón, PI of the Translational Research and Tissue Engineering Group at the University of Alcalá.

Services

 

FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE

U17. Services & Rates

News U17

23 Feb

NANBIOSIS ICTS invites groups and companies to discuss Smart Biomaterials and devices for Drug Delivery

On February 22nd, the National School of Health of the Carlos III Health Institute hosted the forum on Smart Biomaterials and biomedical devices for applications in drug delivery and regenerative medicine, organized by the ICTS Nanbiosis, an infrastructure shared by the CIBER-BBN and the Center of Minimally Invasive Surgery Jesus Usón (CCMIJU). This is the first groups/companies meeting organized by Nanbiosis, in which about 70 B2B meetings  were held. The meeting brought together about 40 participants from 14 research groups (from the CIBER-BBN and the CCMIJU) and 10 companies, which discussed the latest advances in the research lines developed by the groups[...]

16 Nov

Posters presentation by NANBIOSIS Units in CIBER-BBN ANNUAL CONFERENCE 2017

Last 13 and 14 of November, CIBER-BBN  has celebrated its 11th Annual Conference in Hotel Santemar in Santander. In this conference there was a poster session with the participation of the following Units of NANBIOSIS. Special mention deserves Unit 1 with Neus Ferrer as Director and  Paolo Saccardo as Coordinator (in the picture): Posters: U1. Protein Production Platform (PPP): Engineering protein complexes as nano- or micro-structured vehicles or drugs for human and veterinary medicine. Ugutz Unzueta, Naroa Serna, Laura Sánchez-García, José Vicente Carratalá, Olivia Cano-Garrido, Mercedes Márquez, Paolo Saccardo, Rosa Mendoza, Raquel Díaz, Héctor, López-Laguna, Julieta Sánchez, Anna Obando, Amanda Muñoz, Andrés Cisneros, Eric Voltà, Aida Carreño, José[...]

06 Oct

New Zealand White rabbit as a model for preclinical studies addressing tissue repair at the level of the abdominal wall.

Juan Manuel Bellón and Gemma Pascual, Scientific Director and Coordinator of Unit 17 of NANBIOSIS, have recently published an article in the prestigious journal Tissue Eng Part C Methods. Once a prosthetic material is implanted, an inflammatory reaction is induced in an attempt to remove it or isolate it from the host tissue. After this initial response, a cellular response takes place that gives rise to the start of the process of integration of the biomaterial within the host tissue. Immunohistochemical studies can provide information on the events that regulate this process, and are useful to analyze the progression of t[...]

29 Sep

Best Abstract award at the European Society for Surgical Research meeting

Verónica Gómez-Gil, collaborator in Unit 17 of NANBIOSIS and the GITBIT-UAH group (CIBER-BBN), has been the first prizewinner in the Best Abstract Competition  at the symposium “New horizons in prevention and treatment of adhesions” organized by the Dutch Adhesion Group (DAG) at the 52nd meeting of the European Society for Surgical Reseach (ESSR). The ESSR 2017 meeting was held in Amsterdam from 14th till 17th June. The title of the abstract, presented as a quick-shot presentation and a full oral during the congress, was: An experimental adhesiogenic model to evaluate histological events over time in the omentum during adhesion formation.[...]

25 Nov

U17 Nanbiosis-Best picture scientific 2014 award for Ana Belén Fernández Martínez and M. Isabel Trabado Jimenez
Best picture scientific 2014 award for Ana Belén Fernández Martínez and M. Isabel Trabado Jimenez

Ana Belén Fernández Martínez ( Dpt. Of Systems Biology . Faculty of Medicine and Health Sciences , Alcala de Henares) and M. Isabel Trabado Jimenez (CAI Medicine Biology, University of Alcalá) , have been awarded the prize “Best picture scientific 2014 ” , awarded by the Spanish Society of Biochemistry and Molecular Biology ( SEBBM ) . The winning image was published in April 2014 and has been chosen by a jury from among the three most voted in the voting online through our web -site and attending the annual meeting of the SEBBM vote. The picture titled ” larvae hatching[...]

U17-Confocal Microscopy Service
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