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Nanbiosis

U10. Drug Formulation

Ciber bbn

U10. Drug Formulation

  • Scientific Director: Prof. José Luis Pedraz joseluis.pedraz@ehu.es
  • Scientific Coordinator: Dr. Jesús Ciriza Astrain jeciriza@gmail.com
  • Entities: Universidad del País Vasco (UPV/EHU)
  • Address: Pharmacy & Pharmac. Technology Lab.; Facultad de Farmacia, C/Paseo de la Universidad 7, 01006 Vitoria-Gasteiz (Spain)
  • Phone: +34 945 013091
  • Fax: +34 945 013040
  • Web: NANOBIOCEL UPV/EHU
UPV-EHU
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Description

Located at the Faculty of Pharmacy, University of the Basque Country (UPV), Campus of Vitoria, is led by Prof. José Luis Pedraz and consists of large laboratories for: cell culture, chromatography equipment, sample preparation and characterization and one specific for scale preparation of pharmaceutical formulations. This Unit has the capacity to design and evaluate dosage forms both classical and new dosage forms of biotech drugs, DNA, RNA and vaccines using different methodologies based on micro and nano-medicine. The latter methodology based on the microencapsulation of cells, peptides, proteins, and in general of biotech products, as well as the development and design of non-viral vectors for gene therapy, is one of the biggest singularities of this unit. It counts with the most advanced equipment for micro and nano encapsulation.

The aim of the Unit is to determine experimentally all the variables needed to develop an optimal formulation and work instructions for preparing final pharmaceutical products.

The pharmaceutical technology applied to drug development involves the selection of materials and procedures that can be adapted to different processes that lead to specific pharmaceutical forms. To do that, the Unit counts with the most advanced equipment to cover the development for all the steps of the process.

One of the singularities of this Units is that is GLP certified by the Spanish Medicament Agency

News U10

16 May

New gelatine devices that mimic the body’s activity in bone regeneration

The NanoBioCel Group, Coordinator of Unit 10 of NANBIOSIS has led the development of new scaffolds (such as burns, trauma or tumour extractions), to regenerate critical bone defects that, in addition to physical support, offers the opportunity to release growth factors temporarily replacing the bone matrix and aiding the regeneration of bone tissue. In order [...]

18 Apr

New treatments for degenerative diseases of the retina

The final meeting of the TERET project took place last March, an initiative within the RETOS public-private collaboration initiative of the Ministry of Economy, Industry and Competitiveness funded with almost € 1 million. The project has been carried out over the past three years to develop new treatments for degenerative diseases of the retina, focusing [...]

09 Feb

bioprinted human cells
3DBio-impression systems and bio-ink for the regeneration of cartilage and bone

The Nanobiocel Group, coordinator of Unit 10 of NANBIOSIS participate in a public-private collaborative project to reach clinical application in the regeneration of osteochondral lesions, which mainly affect the knee and ankle joints. The new project is funded by the Challenges-Collaboration program of the Ministry of Economy, Industry and Competitiveness. It has a budget of [...]

18 Jan

Nanomedicine in B·Debate Fighting Blindness by Unit 10 of NANBIOSIS
Nanomedicine in B·Debate Fighting Blindness by Unit 10 of NANBIOSIS

The recent published Newsletter of Institut of Màcula and the Barcelona Màcula Foundation: Research for Vision reported about the forum  B·Debate Fighting Blindness. Future Challenges and Opportunities for Visual Restoration, September 6-7 , that gathered more than thirty experts in the different areas related with blindness. The second Session, about Nanotechnology and Nanomedicine, was chaired [...]

13 Jan

Nanbiosis U10 Micro and nano capsules that will increase the effectiveness and precision of medicine.
Micro and nano capsules that will increase the effectiveness and precision of medicine.

José Luis Pedraz, Scientific Director of Unit 10 of NANBIOSIS and members of NANOBIOCEL group, which coordinates Unit 10 of NANBIOSIS, explain for the TEKNOPOLIS program of EiTB, the first communication group in the Basque Country, the development of micro and nanocapsules, gels and scaffolds to solve the problems of administration of new drugs. The [...]

02 Dec

"It is necessary to increase our relationship with European research groups" by José Luis Pedraz - U10 of NANBIOSIS
“It is necessary to increase our relationship with European research groups” by José Luis Pedraz – U10 of NANBIOSIS

Last Sunday, November 27, the Newspaper of Álava published a special supplement with the title “ALAVA 2020”. It contained an article by José Luis Pedraz (Scientific Director of Unit 10 of NANBIOSIS) According to Dr. Pedraz, group leader of the CIBER-BBN NANOBIOCEL group, in the next future, important challenges with new technologies will allow a [...]

04 Oct

Midyear meeting in Vitoria of European project DRIVE
Midyear meeting in Vitoria of European project DRIVE

CIBER-BBN participates in the project through NanoBioCel group, led by professor José Luis Pedraz Muñoz, Scientific Director of Unit 10 of NANBIOSIS, working on the optimization of formulations to be included in a bioartificial organ. José Luis Pedraz Munoz and Jesus Izco coordinator of NANBIOSIS have participated in the meeting held in Vitoria on 3 [...]

03 Jun

Jesus Izco, Coordinator of NANBIOSIS and José Luis Pedraz, Scientific Director of Unit 10-Drug Formulation of NANBIOSIS and NanoBioCel Group of CIBER-BBN, participated in the 2ª General Assambly of DRIVE project, held in Venice, May 16th-17th 2016.
Nanbiosis in the 2ª General Assambly of DRIVE project, Venice (16th-17th 2016)

Jesus Izco, Coordinator of NANBIOSIS and José Luis Pedraz, Scientific Director of Unit 10-Drug Formulation  of NANBIOSIS and NanoBioCel Group of CIBER-BBN, participated in the 2ª General Assambly of  DRIVE project, held in Venice, May 16th-17th 2016. The second General Assembly of European project DRIVE “DIABETES-REVERSING-IMPLANTS FOR ENHANCED VIABILITY AND LONG TERM EFFICACY”, took place [...]

26 Apr

Nanbiosis_U10_Cationic nioplexes in supramolecular hydrogels as hybrid materials to deliver nucleic acids
Cationic nioplexes in supramolecular hydrogels as hybrid materials to deliver nucleic acids

Jose Luis Pedraz, Scientific Director of Unit 10 of NANBIOSIS and Ramon Eritja (CIBER-BBN) have participated in the entrapment of cationic nioplexes in supramolecular hydrogels and the use of these materials for transfecting cells. This work is focused on entrapping cationic nioplexes within supramolecular hydrogels based on N-protected phenylalanine. To modulate the supramolecular hydrogel diffusion [...]

03 Mar

Nanbiosis_Unit8-Drive Project-Improving transplant pancreatic cells_Dr. Jose Luis Pedraz
Drive Project: Improving transplant pancreatic cells

José Luis Pedraz, Scientific Director of the Unit 10: Drug Formulation of NANBIOSIS explained DRIVE European project in the third edition of Diabetes Experience Day, diabetic patients meeting that gathered 1500 people in Madrid. The DRIVE project, in which participate fourteen partners from seven European countries, among which is the CIBER-BBN, develops biomaterials and new surgical devices to improve transplantation and survival of insulin-producing pancreatic islet for the treatment diabetes.

[...]

U10-Drug Formulation
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U11. Pharmaceutical Lab

JUMISC

U11. Pharmaceutical Lab

  • Scientific Coordinator: Dr. Francisco M. Sánchez Margallo msanchez@ccmijesususon.com
  • Entities: Jesus Uson Minimally Invasive Surgery Centre (JUMISC)
  • Address: Carretera N-521, km 41, 10071 Cáceres
  • Phone: + 34 927 181 032
  • Web: JUMISC

 

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Description

The pharmaceutical laboratory is enabled and equipped to store, formulate and reconstitute trial products for differents in vivo preclinical studies carried out by Nanbiosis with strict ISO 9001 quality standards and Good Laboratory Practice (GLP)

U11-Pharmaceutical Lab
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U19. Clinical tests lab

JUMISC

U19. Clinical tests lab

 

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Description

The clinical analysis laboratory performs a wide variety of analysis, including: biochemistry, hematology, coagulation, urinalysis, blood gases analysis, different biomarkers,… in various animal species (rat, mouse, rabbit, pig, sheep, dog, cat). All types of blood, urine and other body fluids tests can be analysed. The laboratory is certified with ISO-9001 and Good laboratory practices (GLP), these strict quality standards allow the production of high accuracy results. Species specific methodologies are used in each animal species according to their physiological and pathological identity.

U19-CLINICAL TESTS LAB
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U21. Experimental operating rooms

JUMISC

U21. Experimental operating rooms

  • Scientific Director: Dr. Francisco M. Sánchez Margallo msanchez@ccmijesususon.com
  • Entities: Jesus Uson Minimally Invasive Surgery Centre (JUMISC)
  • Address: Carretera N-521, km 41, 10071 Cáceres
  • Phone: + 34 927 181 032
  • Web: JUMISC

 

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Description

Experimental operating rooms with high technology and high field instrumentation to promote methodological and translational research class in Biomedicine, both minimally invasive surgery and new procedures and in preclinical development for technical evaluation, medical devices, biomaterials, etc. Surgical facilities allow the development and use of small and large animal models for research and experimental surgery in several longitudinal areas: cardiovascular diseases, liver and digestive diseases, respiratory and systemic diseases, endocrinology and urology, gynecological and reproductive diseases, pediatric diseases, orthopedics and traumatology, ophthalmology and experimental surgery in all organ systems have the infrastructure for transplant development, implants, prosthesis, biomaterials, etc. under high quality experimental conditions that allow surgery, clinical follow up and obtaining biological samples in these models.

U21. Experimental operating rooms
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U22. Animal housing

JUMISC

U22. Animal housing

  • Scientific Director: Luis Dávila Gómez ldavila@ccmijesususon.com
  • Entities: Jesus Uson Minimally Invasive Surgery Centre (JUMISC)
  • Address: Carretera N-521, km 41, 10071 Cáceres
  • Phone: + 34 927 181 032
  • Web: JUMISC

 

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Description

The JUMISC Animal Housing Unit provides services to companies and research groups in many preclinical trials. This unit advises designs and conducts preclinical validation on demand. It has qualified professionals to design, monitor and validate any type of biomedical study. In addition this unit has been certified by the Spanish Agency of Medicines and Health Products (AEMPS) for studies in “Dosing of test substance and non-clinical specimen drawing” and “Biocompatibility studies of medical devices”. These two new certifications are attached to existing “in vivo toxicity”, “Tolerance” and “Pharmacodynamics”. All these certifications allow NANBIOSIS members to perform studies to verify the effectiveness, safety and biocompatibility of nanotechnology under development. A most singular fact makes this unit is the possibility of housing, maintaining and supervising large animals for preclinical validations. This Service has extensive experience in handling and care of minipigs and what it entails use in preclinical studies.

Its perimeter area is 3,200 m2, and the net floor area is 2,865 m2. It has large rooms to house the experimental animals according to their species characteristics (age, sex, weight, breed) and to the research projects they are assigned to. Among the equipment and facilities include: rooms for the maintenance of large animals, rooms for maintaining small ruminants, barrier zone for maintenance of rodents under SPF conditions, integrated operating room within the barrier area, multi-use rooms for rodents and lagomorphs maintenance, room for receipt and handling of animals, quarantine rooms pre-experimental process, room to perform small procedures and cures and preparation rooms for large animals prior to the surgical area.

This unit has facilities with a perimeter area of 3,200 m2 and it has large rooms to house the experimental animals according to their species characteristics.

U22-Animal housing
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