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Nanbiosis

U2. Custom Antibody Service Unit (CAbS)

U2 CAbS-hybridoma clone
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U2. Custom Antibody Service (CAbS)

  • Scientific Director: Prof. Pilar Marco pilar.marco@cid.csic.es
  • Scientific Coordinator: Dra. Nuria Pascual npdqob@cid.csic.es
  • Entities: Institute of Avanced Chemistry of Catalonia (IQAC) & Consejo Superior de Investigaciones Científicas (CSIC)
  • Address: Jordi Girona, 18-26, 088034, Barcelona, Spain
  • Phone: +34 934 006 100
  • Web: IQAC- CSIC

IQAC CSIC

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Description

The facility is located in the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC; Barcelona). It is equipped with a laboratory for the development and production of monoclonal antibodies. The laboratory is fully equipped for obtaining, selecting and storing monoclonal antibody producing hybridomas. In addition, the facility has infrastructure for the production of polyclonal antibodies, as well as laboratories for the synthesis of bioconjugates, haptens, the purification of antibodies and the performance of immunoassays. In addition to the above mentioned equipment, the IQAC-CSIC provides animal husbandry facilities and a unit for the synthesis of organic molecules.

The equipment consists in an inverted phase contrast microscope with a camera, two Class II laminar flow biological safety cabinets, two CO2 incubators, a bioreactor for hybridoma culture, and tangential filtration unit for purification of the antibodies produced in the culture. Among the items of available equipment it should be highlighted a spotter for selection of high antibody producing cell lines and an automated ELISA microplate washer an ELISA reader, two AKTA Prime Liquid chromatography systems for antibody purification, plus standard equipment (centrifuges, fridges, liquid nitrogen containers, autoclave, baths, and vacuum equipment) and all the necessary routine laboratory apparatus.Cabs also has access to a fully equipped chemistry laboratory for the synthesis of haptens and immunoreagents.

News U2

17 Apr

Unit 2 Nanbiosis have signed an agreement with a Belgian Enterprise.

U2 unit of Nanbiosis (Custom antibody service) has recently signed a 3-year contract with UNISENSOR S.A. (Liege, Belgium) for producing on a high scale a collection of immunoreagents used in their diagnostic kits. UNISENSOR S.A. is a SME biotech company that develops on site diagnostic systems for food safety. Unit 2 of NANBIOSIS, coordinated by Nb4D-CSIC holds a research collaboration for more than 7 years developing new bioproducts and transferring knowledge to UNISENSOR S.A. As result of the collaboration several diagnostic kits are nowadays in the market, consequently this contract has been signed with the aim to supply UNISENSOR S.A. with immunoreagents for their[...]

19 Dec

NANBIOSIS in three projects funded by CaixaIMPULSE.
NANBIOSIS in three projects funded by CaixaIMPULSE

La Caixa has just presented the twenty projects selected by CaixaImpulse in a call with more than 70 proposals from different research centres, hospitals and universities. CaixaImpulse is an initiative unique in Spain that aims to boost research in biotechnology and life sciences to develop projects that generate value in society. Among the selected projects there are two coordinated by NANBIOSIS researchers: Pseudomonas aeruginosa diagnosis led by Miriam Corredor Sánchez (Unit 2 of NANBIOSIS) and ISCHEMSURG, led by Monica Mir (Unit 7 of NANBIOSIS). In addition, the project ExoLiver, in which participates Rosa Villa and the research group coordinating Unit 8[...]

06 Dec

Unit 2 of NANBIOSIS participates in the FoodSmartPhone project of Marie Sklodowska Curie.
Unit 2 of NANBIOSIS participates in the FoodSmartPhone project of Marie Sklodowska Curie.

The Nb4D group of CSIC, coordinator of Unit 2 of NANBIOSIS led by Pilar Marco has joined the consortium for the FoodSmartPhone project funded by the Marie Sklodowska Curie Research Program. The Marie Sklodowska-Curie Actions (MSCA) support training in research and professional development aimed at innovation skills. The objective of the project is to develop a smartphone-based diagnostic and detection tool for simplified quick pre-selection of food quality and safety parameters. This is because food safety and quality tests are currently inefficient, expensive and ineffective and can not guarantee food safety for all consumers or prevent possible incidents of food[...]

20 Apr

Nanbiosis_U2_Nanobiotechnology for Diagnostics Group awarded with TECNIO grant to encourage Technology Transfer
Nanobiotechnology for Diagnostics Group awarded with TECNIO grant to encourage Technology Transfer

The Nanobiotechnology for Diagnostics Group (Nb4D), the host group for the Custom Antibody Service of Unit 2 of NANBIOSIS was recently awarded with grant that ACCIÓ provides to groups who are seeking to be accredited with the TECNIO seal. The aim is to help define and boost their action plans for technology transfer. These grants are destined at financing for 3 years the integration of these groups in the UAB-CEI sphere of the TECNIO network. The group will use this finance for activities related to the execution during the first year of a growth plan to increase their technology transfer[...]

U2-Custom Antibody Service (CAbS)
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U4. Biodeposition and Biodetection Unit

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U4. Biodeposition and Biodetection Unit

  • Scientific Director: Prof. Laura Lechuga laura.lechuga@icn2.cat
  • Scientific Coordinator: Dr. MªCarmen Estevez mcarmen.estevez@icn2.cat
  • Entities: Research Center on Nanoscience and Nanotechnology CIN2 & CSIC
  • Address: Campus Bellaterra, 08193 Cerdanyola del Vallés, Barcelona, Spain
  • Service Contact mail: nanob2a@icn2.cat
  • Phone: +34 937 374 617
  • Web: CIN2
CIN2_U4 CSIC
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Description

Located at the Research Center onNanoscience and Nanotechnology(CIN2), CSIC, at the campus of Universidad Autónoma de Barcelona (UAB) the Biodeposition Unit consists of a versatile and automated molecular printer that can dispense minute volumes of solutions (from atto to femtoliter volumes) on a wide variety of surfaces to create user-defined patterns of spots or lines with high spatial resolution. The system is suitable for the functionalization of biosensors with any kind of biomolecule, nanoparticles, graphene or other nanostructures,for surface patterning for cell culture, or for the preparation of micro/nanoarrays, among other applications. The laboratory also harbors a Surface Plasmon Resonance (SPR) service. The Unit is coordinated by Prof. LauraM. Lechuga, group leader from the Nanobiosensorsand Bioanalytical Applications Group (nanoB2A) at CIN2-CSIC.

News U4

22 Jun

New methodology for cancer screening paves the way for more targeted treatment options

Laura Lechuga, Scientific Director of Unit 4 of NANBIOSIS, is co-author of a new paper published in Scientific Reports. According to Cesar Huertas, co-author of the article, the Gene expression is the process by which information from a gene is converted into a functional product, such as a protein. It is controlled by a complex regulatory network wherein diverse cellular mechanisms enable the cell to respond to its ever-changing environment. One such mechanism is alternative splicing (AS) of mRNA precursors, a particularly flexible regulatory control point where diverse protein isoforms of differing, even opposing, functions are generated. However, these regulation[...]

04 May

Laura Lechuga in the fight against cancer

Dr. Laura Lechuga, Scientific Director of Unit 4 of NANBIOSIS is highlighted in Cinco Días. Elpais Economía  for its fight against cancer and, in particular, for the device developed with its team to detect the disease in matter of minutes “Have you ever wondered why glucose meters are so smart that they just measure sugar? The answer is that they carry specific proteins that only interact with sugar, “explains the doctor.  The same idea lies in the device designed by Laura Lechuga and her research group “With a minimum sample of the patient, it is possible to detect the presenc[...]

06 Feb

A multiplexing nanophotonic biosensor for cancer diagnosis
A multiplexing nanophotonic biosensor for cancer diagnosis

The group Biosensors and bio-analytic applications, led by Laura Lechuga,​ coordinator of Unit 4 of NANBIOSIS, has developed a methodology through a nano-photonic sensor (known as bimodal waveguide interferometer) capable of quantifying, directly and mark-free, the different messenger RNA isoforms generated by alternative splicing. The expertise in biodeposition and biodetection systems of Lechuga’s group has permitted a thorough analytical study and optimization of the methodology, achieving not only total selectivity, but also excellent levels of sensitivity and reproducibility, and obtaining the lowest levels of detection in direct detection of messenger RNA isoforms generated by this mechanism without the need for PCR amplification (polymerase chain reaction). T[...]

19 Dec

Laura Lechuga received the Physics, Innovation and Technology Prize
Laura Lechuga received the Physics, Innovation and Technology Prize

On December 14th, the Physics Awards ceremony was held at the BBVA Foundation’s headquarters, organized by the Spanish Royal Society of Physics (RSEF) and the BBVA Foundation, that each year select the most relevant achievements of Spanish physics. On this occasion the achievements of nanoscience have been recognized and it has been highlighted the power of physics to expand the territory of the known universe and the role of scientists as a core element of social progress. Professor Laura Lechuga, Scientific Director of Unit 4 of NANBIOSIS received the Physics, Innovation and Technology Prize was the only woman awarded. Lechuga[...]

24 Oct

Physics Prize of the Royal Spanish Society of Physics (RSEF) to Laura Lechuga
Physics Prize of the Royal Spanish Society of Physics (RSEF) to Laura Lechuga

Laura M. Lechuga, Scientific Director of the Unit 4 of NANBIOSIS has won the Physics Prize of the Royal Spanish Society of Physics (RSEF) -Foundation BBVA 2016 in the form of Physics, Innovation and Technology, endowed with 8,000 euros. Physics Awards recognize this year to researchers who have revealed the potential of the “nanoworld” to create new materials and fight disease. The jury highlighted her “excellent track record as a scientist, technologist and innovative” in the field of biosensor devices. “Prof. Lechuga – emphasizes the jury- has managed to walk the path from idea to product with great success. Her[...]

03 Oct

Laura Lechuga, Scientific Director of the Unit 4 of NANBIOSIS in the Spanish Selection of Science.
Laura Lechuga, Scientific Director of the Unit 4 of NANBIOSIS in the Spanish Selection of Science.

The selection of the best Spanish researchers in 2016 is an initiative of the magazine QUO to disseminate the work of scientists. The jury formed by eight eminent scientists (Amils, Ainhoa Goni, Emilio Lora-Tamayo, Vladimir de Semir, Fernando Peláez, Antonio Calvo, Pilar López and Manuel Toharia, has chosen the twelve scientists of international prestige who will form the Spanish National Science 2016: – Pedro Cavadas, plastic surgeon specializing in transplants – Mariano Barbacid, a biochemist at the National Cancer Research Centre (CNIO) – Susana Marcos, director of the Institute of Optics ‘Daza Valdes’ CSIC – Alberto Ruiz Jimeno, founder of[...]

26 Aug

Nanotechnology bio applications in the clinical diagnosis II biosensor BiMW for the early diagnosis of bacterial infections in cirrhotic patients
Nanotechnology bio applications in the clinical diagnosis II: biosensor BiMW for the early diagnosis of bacterial infections in cirrhotic patients

The peritonitis bacterial spontaneous is an infection of the fluid ascetic that has high incidence in cirrhotic patients and is associated with a high mortality. In such situation, a diagnosis early is essential for the survival of the patient. However, the identification of the causative pathogen of infection is based currently on cultivation methods that are slow and laborious. A research coordinated by the Group of Nanobiosensors and Bioanalytical applications of the CIBER-BBN, which coordinates Unit 4 of NANBIOSIS led by Laura Lechuga, has presented the development of a biosensor interferometric based in guides bimodal (BiMW), capable of identify and[...]

25 Aug

Nanotechnology bio applications in the clinical diagnosis nanoplasmodic biosensor device for the early diagnosis of colorectal cancer
Nanotechnology bio applications in the clinical diagnosis: nanoplasmodic biosensor device for the early diagnosis of colorectal cancer

The group of Nano-biosensors and Bioanalytical applications of CIBER-BBN which coordinates Unit 4 of NANBIOSIS directed by Dr. Laura Lechuga, has led the final preparations of a technology with potential application in the early diagnosis of colorectal cancer, based in the detection of specific biomarkers in blood. The nanoplasmonic biosensor based on LSPR (Localized Surface Plasmon Resonance) is generated on structured surfaces of nano discs of gold, that allow monitoring of biological interactions in real time and without the need of markers. The nanoplasmonic biosensor allows analysis of human samples in a few minutes, without requiring reagents or additional instrumentation.[...]

U4-Biodeposition and Biodetection Unit
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U7. Nanotechnology Unit

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U7. Nanotechnology Unit

  • Scientific Director: Prof. Josep Samitier jsamitier@ub.edu
  • Scientific Coordinator: Dr. Isabel Oliveira ioliveira@ibecbarcelona.eu
  • Scientific Coordinator: Dr. Mateu Pla Roca mpla@ibecbarcelona.eu
  • Entities: Intitute of Bioengineering of Catalonia (IBEC)
  • Address: C/Baldiri I Reixac, 10, 08028, Barcelona, Spain
  • Phone: +34 934 037 138
  • Web: IBEC
IBEC
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Description

The Nanotechnology Platform is part of the institute’s long-term strategic plan to create new Core Facilities in nanofabrication and bionanocharacterization. Currently, the platform is an accessible and versatile research facility featuring 150m2 of class 10,000 cleanroom space and laboratories offering state-of-the-art equipment for the fabrication and characterization of micro- and nanodevices and structures. Our aim is to facilitate advanced research by providing services in the fields of nanoscience and nanotechnology for all academic and industrial researchers. Some of the many areas of application include nanobioengineering, BioMEMS, materials science, tissue engineering, optic and biomaterials. IBEC’s Nanotechnology Platform offers scientific and technological support that includes the design, development and analysis of devices, materials, and processes, so that academic researchers and companies alike may use the platform to develop their innovative ideas.

News U7

13 Jul

3D bioprinting applied to cancer diagnostics

Mateu Pla Roca, Scientific Coordinator of Unit 7 of NANBIOSIS /IBEC Core Facilities has won CaixaImpulse funding for his project “3D bioprinted array tissue-like cores: tissue-like controls for cancer diagnostics” (3DBIOcores), which will be carried out in collaboration with Antoni Martinez, head of the histopathology service at Hospital Clinic. CaixaImpulse programme aims to promote technology transfer in science. The project 3DBIOcores will take advantage of 3D bioprinting to create quality control samples that assure and improve cancer diagnostics. Usually, diagnosis is done by histopathology – the microscopic examination of tissues – and then the biomarkers that are found are quantified. However,[...]

19 Dec

NANBIOSIS in three projects funded by CaixaIMPULSE.
NANBIOSIS in three projects funded by CaixaIMPULSE

La Caixa has just presented the twenty projects selected by CaixaImpulse in a call with more than 70 proposals from different research centres, hospitals and universities. CaixaImpulse is an initiative unique in Spain that aims to boost research in biotechnology and life sciences to develop projects that generate value in society. Among the selected projects there are two coordinated by NANBIOSIS researchers: Pseudomonas aeruginosa diagnosis led by Miriam Corredor Sánchez (Unit 2 of NANBIOSIS) and ISCHEMSURG, led by Monica Mir (Unit 7 of NANBIOSIS). In addition, the project ExoLiver, in which participates Rosa Villa and the research group coordinating Unit 8[...]

07 Apr

Josep Samitier, Scientific Director of Unit 7 of NANBIOSIS_named new president of ACER
Josep Samitier, Scientific Director of Unit 7 of NANBIOSIS, was named new president of ACER

Associació Catalana d’Entitats de Recerca (ACER) is an independent association of more than 40 institutions in Catalonia – including CRG, IRB, ICFO, IBEC, VHIR and IDIBAPS – which conduct research as their principal mission. The collective vocation of the associated organisations is to contribute to defining the scientific and research priorities and policies in Catalonia, and to optimise their management and implementation in their respective areas  by representing its associated centres, encouraging collaboration and the coordinated exchange of information, promoting synergies with similar agencies related to local, national or international research, and contributing to the improvement of scientific understanding in[...]

U7-Nanotechnology Unit
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U8. Micro – Nano Technology Unit

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U8. Micro – Nano Technology Unit

  • Scientific Coordinator: Dr. Gemma Gabriel gemma.gabriel@imb-cnm.csic.es
  • Entities: Instituto de Microelectrónica de Barcelona – Cenro Nacioal de Microelectrónica (IMB-CNM, CSIC)
  • Address: Campus UAB, 08193, Cerdanyola del Vallés, Barcelona, Spain
  • Phone: +34 935 947 700 ext. 1208
  • Web: IMB – CNM, CSIC

 

CNM CSIC
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Description

This Micro-Nano Technologies Unit is located in the Microelectronic Institute of Barcelona, (IMB-CNM, CSIC) which is the largest installation with micro-nano technologies facilities in Spain. Its 1500 m2 Clean Room classes 10 to 10,000 are considered as Singular Scientific-Technical Infrastructure (ICTS). The platform is coordinated by Dr. Jordi Aguiló and this unit is based on a CVD (chemical vapor deposition) equipment for the controlled growth of carbon nanotubes (CNTs).
The integration of the unit in the clean room facilities of the IMB-CNM enables a complete range of processes (thermal processes and CVD, metallization, photolithography, dry and wet etching) for the complete fabrication of MNBS devices. So, from the platform it is supported the whole MNBS fabrication steps: the customization of the technology needed, the design of the devices, the complete fabrication process, their encapsulation, the characterization and test up to the technological support on the experimental uses.

News U8

19 Dec

Extraordinary doctoral award to Anton Guimerà Brunet
Extraordinary doctoral award

Anton Guimerà Brunet, member of the GBIO group that coordinates Unit 8 of NANBIOSIS, has obtained the extraordinary doctoral award from the Universitat Autònoma de Barcelona for his thesis “Novel methods and tools for corneal barrier function assessment through non-invasive impedance measurements”. This thesis was directed by Rosa Villa, Scientific Director of Unit 8 of NANBIOSIS. The thesis covers aspects of basic research as applied, reaching the transference to the biomedical industrial sector and solving a need in the ophthalmological diagnosis to be able to quantify the degree of corneal permeability. This innovation also includes the development of a flexib[...]

19 Dec

NANBIOSIS in three projects funded by CaixaIMPULSE.
NANBIOSIS in three projects funded by CaixaIMPULSE

La Caixa has just presented the twenty projects selected by CaixaImpulse in a call with more than 70 proposals from different research centres, hospitals and universities. CaixaImpulse is an initiative unique in Spain that aims to boost research in biotechnology and life sciences to develop projects that generate value in society. Among the selected projects there are two coordinated by NANBIOSIS researchers: Pseudomonas aeruginosa diagnosis led by Miriam Corredor Sánchez (Unit 2 of NANBIOSIS) and ISCHEMSURG, led by Monica Mir (Unit 7 of NANBIOSIS). In addition, the project ExoLiver, in which participates Rosa Villa and the research group coordinating Unit 8[...]

06 Dec

The Journal “Diario Médico” awards the project "Liver on a chip" participated by researchers of U8 of NANBIOSIS
The Journal “Diario Médico” awards the project “Liver on a chip” participated by researchers of U8 of NANBIOSIS

The 15th edition of  “Best Ideas 2016” by Diario Médico, has awarded the “Liver on a Chip” project, coordinated by Rosa Villa, Scientific Coordinator of Unit 8 of NANBIOSIS. “Liver on a chip” is a microfluidic camera that simulates hepatic microcirculation and will serve as a tool for in vitro studies and diagnostics of cell function, pharmacology, toxicity and personalized medicine. The device could be applicable to any other biomedical research in That the vascular system has relevance (liver, kidney, cardiovascular and others). This project was already recognized last July with the second prize of the category of innovation in[...]

22 Nov

Graphene will revolutionize the world
Graphene will revolutionize the world

Elisabet Prats, researcer of the GBIO Group, coordinator of Unit 8 of NANBIOSIS, participated in the  #ImproCiencia dissemination event, held on November 16 in Madrid organized by CIBER. Elisabet presented the Neurographene project as a monologue and explained how they are using graphene for Measure the electrical activity of the brain. Based on the latest microfabrication technologies, the devices consist of graphene microsensor matrices mounted on flexible polymer substrates that adapt to the surface morphology of the brain. Each sensor detects tiny changes in the electrical activity around it. Thus, the electrical activity generated by the neurons is detected as[...]

08 Jul

Pablo Laguna and Jordi Aguilo, Scientific Directors of the Units 27 and 8 of NANBIOSIS participate in the European program Remote Assessment
Pablo Laguna and Jordi Aguilo, Scientific Directors of the Units 27 and 8 of NANBIOSIS participate in the European program Remote Assessment of Disease and Relapse in Central Nervous System Disorders (RADAR-CNS)

RADAR-CNS is an important European research program supported by the Innovative Medicines Initiative (IMI) focused to develop new ways of monitoring patients affected by major depression, epilepsy and multiple sclerosis, with the use of wearable technology and smart mobile phones. This program brings together experts from various disciplines in clinical research, engineering, computer and data analysis, as well as health services. RADAR-CN aims to improve symptoms and quality of life of patients and treatment of these and other chronic diseases. This program is jointly led by King’s College London and the pharmaceutical company Janssen and is funded by the Innovative Medicines[...]

14 Apr

Nanbiosis_U8_Graphene Flagship for Biomedical Tecnologies
Graphene Flagship for Biomedical Tecnologies – Kick off meeting April 11-14 Barcelona

On April, 11-12 took place in Barcelona the kick off meeting of the new Graphene Flagship Work Package devoted to Biomedical Technologies, one emerging application area for graphene and other 2D materials. The Kick-off event, was co-organised by Dr. Rosa Villa (CNM-IMB-CSIC, CIBER-BBN) Scientific Coordinator of Unit 8 of NANBIOSIS (in the center of the first row in the photo). More than 35 Scientifics from 14 research groups attended to the meeting The Graphene Flagship, the EU’s biggest ever research initiative, involves the coordination research of over 150 partners from more than 20 European countries withing a timeframe of 10[...]

11 Mar

Nanbiosis_U8 - Biomedical applications of graphene, Elisabet Prats in Informativos.net
Biomedical applications of graphene: Elisabet Prats in Informativos.net

[Elisabet Prats in Informativos.net] As a science disseminator, Elisabet has recently appeared in media and forums explaining the progress made by her research group in the European project Graphene Flagship. For example, a graphene sensor to detect brain electrical activity, successfully presented at Mobile World Congress. Elisabet clearly explains “We are able to measure the electrical signals of the brain with graphene, graphene due to its versatility, allows the reduction in size of the sensors, giving much more information to the doctor” and describes a future in which “we shall control mechanical arms with brains implants”.[...]

24 Feb

Nanbiosis_Unit8-Graphene sensors presented in Mobile World Congress Barcelona 2016
Graphene sensors partially developed in UNIT 8 of NANBIOSIS are presented at the Mobile World Congress in Barcelona

These devices, that can detect the electrical activity of the brain, are currently being tested in animals by measuring their brain activity using  Graphene transitors and could have therapeutic applications, as well as allowing the design of new brain-machine interfaces.[...]

U8-Micro-Nano Technology Unit
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