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Nanbiosis

U5. Rapid Prototyping Unit

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U5. Rapid Prototyping Unit

  • Scientific Director: Prof. Elisabeth Engel elisabeth.engel@upc.edu
  • Scientific Coordinator: Miguel Angel Mateos mamateos@ibecbarcelona.eu
  • Entities: Biomaterials for Regenerative Therapies Group & Intitute of Bioengineering of Catalonia (IBEC)
  • Address: C/BaldiriReixac 15-21, 08028, Barcelona, Spain
  • Phone: +34 934 039 735
  • Web: IBEC

IBEC

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Description

This facility is headed by Dr. Elisabeth Engel, PI of the Biomaterials for Regenerative Therapies Group at the Institute for Bioengineering of Catalonia (IBEC) and counts with a laboratory equipped to produce 3D structures of different materials. This system allows the fabrication of 3D porous scaffolds of defined geometry and porosity for tissue engineering applications. Dispensing and locating cells in specific positions on defined substrates is also possible due to the high precision levels of this tool.

Services

 

FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE

U5. Services & Rates

News U5

28 Feb

3D printing biocompatible hydrogels

  Researchers of Unit 5 of NANBIOSIS, in collaboration with colleagues from the University of Montpellier, have laid the groundwork for faster advances in 3D printing for regenerative medicine by creating a system of ink and matrices that offers a solid basis for tissue regeneration. Due to their high water content, hydrogels are highly attractive biomaterials for 3D printing as efficient ‘surrogates’ for the extracellular matrix, onto which cells can be cultured. However, while they are relatively easy to produce using a method called extrusion printing, their stability and structural integrity can weaken when they’re in contact with biological fluids[...]

21 Dec

EIT Health Spain awards the best innovation and entrepreneurship projects
EIT Health Spain awards the best innovation and entrepreneurship projects

Elisabeth Engel, Scientific Director of Unit 5 of NANBIOSIS, has received an award at EIT Health Spain event held this month at the PCB, Barcelona.  The awards have been organized by the Spanish node during 2016 and are part of the financing initiatives of the EIT Health accelerator. Professor Engel participated in the category of ‘Proof of Concept (PoC)” that recognises projects and business ideas that are in stages prior to the creation of the company and projects that are participating in acceleration programs in health. Elisabeth won a prize funded with 25.000 € for Dermoglass, the smart dressing for[...]

13 Sep

Elisabeth Engel stimulating scientific talent in the Barcelona International Youth Science Challenge
Elisabeth Engel stimulating scientific talent in the Barcelona International Youth Science Challenge (BIYSC)

Dr. Engel, Scentific Director of Unit 5 of NANBIOSIS, participated in the Barcelona International Youth Science Challenge (BIYSC) held in Barcelona from July 11th to 22nd 2016. Ms. Elisabeth gave the lecture “Biomaterials beyond a simple template”, introducing the students to the breakthrough in the medical and social  field of obtaining a synthetic biomaterial that eludes the need of cell therapy or the application of morphogens and growth factors. The research group led by Elisabeth Engel hosted one of the projects of this programme: “Instructive Biomaterials for Regenerative Medicine” dealing with replacement or regeneration of human cells, tissues or organs,[...]

05 Jul

Elizabeth Engel, Scientific Coordinator of Unit 5 of NANBIOSIS: “Our research has opened the door to the regeneration of the nervous system by biomaterials”
Elizabeth Engel, Scientific Coordinator of Unit 5 of NANBIOSIS: “Our research has opened the door to the regeneration of the nervous system by biomaterials”

The CIBER-BBN research group Biomaterials for Regenerative Therapies, which coordinates Unit 5 of NANBIOSIS develops various lines of research on biomaterials for regenerative therapies, especially focusing on the design and fabrication of scaffolds for tissue regeneration. They are working with polymers, hydrogels and compounds that can be manufactured using different techniques such as electrospinning to make 3D printing matrices or scaffolding. Applications are diverse, such as bone regeneration, neuronal, skin or cell therapy. The group has recently presented the results of a project focused on the development of implants for the regeneration of nerve tissue with very promising results. T[...]

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U13. Tissue & Scaffold Characterization Unit

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U13. Tissue & Scaffold Characterization Unit

  • Scientific Director: Prof. Manuel Doblaré mdoblare@unizar.es
  • Scientific Coordinator: Fany Peña fany@uniza.es
  • Entities: Universidad de Zaragoza. Departamento de Ingeniería Mecánica.
  • Address: Campus Río Ebro. Edificio I D I. C/ María de Luna, S/N, 50018 Zaragoza, Spain
  • Phone: 34 976 761 000 ext 5233 / 34 976 761 912
  • Web: I3A-UZ

Nanabiosis-logo Universidad de Zarargoza-U9-U13-U27.
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Description

This platform is coordinated by Dr. E. Peña member of the Applied Mechanics and Bioengineering Group of the Aragón Institute of Engineering Research (I3A) at the University of Zaragoza. The objective of this unit is to provide services for structural and physical characterization of biological tissues and tissue scaffolding, including microstructure, histology and mechanical tests among others. This platform, unique in Spain as regarding its capability, has a clear and direct translational impact, especially in regenerative medicine, implant design and evaluation, as well as in the study of the mechanical behavior of living tissues (especially in the musculoskeletal and cardiovascular systems). Its relationship with the Instituto Aragonés de Ciencias de la Salud (Health Sciences Institute of Aragon), and through it with the Tissue and Blood Bank of Aragon and with the School of Veterinary Science at the Universidad de Zaragoza, allows an easy provision of tissues both from animals (mice, rabbit, sheep, pig) and humans, following in their handling the recommendations of the different ethics committees.

It has several types of INSTRON testing machines specializedin biological tissues, for the characterizationof soft tissues and fibers, as well as an X-ray microCT which allows quantitatively characterizing the microstructure of in vitro samples of hard tissues and of biomaterials for scaffolds. It also has the entire system necessary for performing high-quality histologies which would complete the structural characterization of the previously cited types of tissues (staining of preparations, immunohistochemistry in paraffin with EnVision, laser microdissection, etc.). As additional tests, equipment for determining the permeability of biological tissues and scaffolds under culture conditions, monitoring their variation over time is also available. Finally, the platform is also composed of different types of bioreactors, including perfusion or direct compression on seeded scaffolds for stimulating cell cultures for tissue engineering applications.

News U13

17 Nov

Unit 13 of NANBIOSIS participates in a new European project that will boost the Organ-on-Chip technology

The research group coordinating NANBIOSIS Unit 13 is the Spanish group of the European project ORCHID (Organ-On-Chip In Development). The scientists  of Engineering Research Institute (I3A) and CIBER-BBN, Luis Fernández and Iñaki Ochoa, will work on this project whose objective is to accelerate the social and economic impact of the technology known as Organ-on-Chip. This technology based on the use of microfluidic platforms is already facilitating the discovery of drugs, but it can go a step further with applications in personalized medicine and safety pharmacology and that, in addition, offers alternatives to conventional tests in animals. The mechanical properties and[...]

16 Nov

Posters presentation by NANBIOSIS Units in CIBER-BBN ANNUAL CONFERENCE 2017

Last 13 and 14 of November, CIBER-BBN  has celebrated its 11th Annual Conference in Hotel Santemar in Santander. In this conference there was a poster session with the participation of the following Units of NANBIOSIS. Special mention deserves Unit 1 with Neus Ferrer as Director and  Paolo Saccardo as Coordinator (in the picture): Posters: U1. Protein Production Platform (PPP): Engineering protein complexes as nano- or micro-structured vehicles or drugs for human and veterinary medicine. Ugutz Unzueta, Naroa Serna, Laura Sánchez-García, José Vicente Carratalá, Olivia Cano-Garrido, Mercedes Márquez, Paolo Saccardo, Rosa Mendoza, Raquel Díaz, Héctor, López-Laguna, Julieta Sánchez, Anna Obando, Amanda Muñoz, Andrés Cisneros, Eric Voltà, Aida Carreño, José[...]

02 Jun

NANBIOSIS at the VI Conference of Young Researchers

On June 2, the VI Conference of Young Researchers organized by the I3A at the University of Zaragoza was held, aimed at doctoral students who have as director or co-director an I3A member. The inaugural lecture was given by José Antonio Sanz Herrera (Professor Contractor Doctor at the University of Seville and who held his doctorate at I3A) who has talked about Multidisciplinary Research as the basis of the young professor in engineering. After the inaugural conference a first block was opened with four oral presentations, giving way to the poster session and coffee. A second and final block wit[...]

14 Feb

Bioengineering is being strengthened in Spain

Estefanía Peña, Scientific Coordinator of Unit 13 of NANBIOSIS explains her resarch in the program “En route with science” of Aragon Television. Bioengineering consists in the application of the principles of engineering to the field of medicine. In the opinion of Estefanía, coordinator of the Division of Biomedical Engineering and deputy director of I3A (Institute of Research in Engineering of Aragon) Bioingineering is being strengthened in Spain. “Our research develops mathematical models and computational reproduction, especially of cardiovascular diseases and the therapies to solve them. Fundamentally we work on atherosclerosis, which is the appearance and development of atheroma plaque (a cluster of[...]

16 Dec

Best oral communication at the National Congress of Young Researchers in Biomedicine
Best oral communication at the National Congress of Young Researchers in Biomedicine

María Virumbrales, PhD candidate in the research group coordinating of Unit 13 of NANBIOSIS, has been awarded the Prize to the Best Oral Presentation in the I National Congress for Young Researchers in Biomedicine, which took place in Valencia, Spain, on the 28th-29th of November, 2016. The title of the communication was: “Tubeless microfluidic device to mimic tumor microenvironment and monitor cancer-endothelium interactions”. The talk described an in vitro 3D model closely resembling biological tissues and blood vessels, established within a biocompatible material. This model is currently being used to recreate breast tumor microenvironment and evaluate drug efficiency within. [...]

21 Nov

New 3D culture device to better understand how tumours work
New 3D culture device to better understand how tumours work

Scientist of NANBIOSIS in collaboration with other CIBER-BBN researchers have developed a sophisticated microfluidic biomedicine device capable of reproducing in vitro and by 3D bioprinting the complexity of different tumour types. This device allows tumour cells to grow in a 3D environment where nutrients and oxygen are supplied in a controlled way through small capillaries, thus mimicking the body’s own blood vessels. Thanks to this new technology, it is now possible to reproduce in a controlled way all the processes of the tumour environment, which could help to develop new treatments and combinations of drugs that are more effective for[...]

21 Nov

Three Universities among the 200 best in the world in science, hosting 4 Units of NANBIOSIS.
4 Units of NANBIOSIS hosted in three Universities among the 200 best in the world in science.

The University of Zaragoza is one of the 200 best universities in the world in science research, according to the latest Shanghai ranking of 2016 in a specific analysis by macro areas. In order to elaborate this ranking by macroareas indicators such as the number of students and professors who have obtained the Nobel prize or Fields medal, the number of researchers highly cited in the scientific literature, the number of scientific articles indexed in the Science Citation Index and the Percentage of articles published in the most cited 20% scientific journals are used. Only six Spanish universities are among[...]

U13-Tissue & Scaffold Characterization Unit
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U14. Cell Therapy

JUMISC

U14. Cell Therapy

  • Scientific Director: Dr. Javier García Casado jgarcia@ccmijesususon.com
  • Entities: Jesus Uson Minimally Invasive Surgery Centre (JUMISC)
  • Address: Carretera N-521, km 41, 10071 Cáceres
  • Phone: + 34 927 181 032
  • Web: JUMISC

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Description

Laboratory with an area of 81,02 m2 for cell biology and molecular biology techniques. The laboratory is also equipped with two cell culture rooms for the isolation, expansion and characterization of different cell types.

U14-Cell Therapy
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U16. Surface Characterization and Calorimetry Unit

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U16. Surface Characterization and Calorimetry Unit

  • Scientific Director: Prof. M Luisa González Martín mlglez@unex.es
  • Scientific Coordinator: Prof. M Luisa González Martín mlglez@unex.es
  • Entities: Universidad de Extremadura
  • Address: Avda Elvas, S/N, 06006, Badajoz, Spain
  • Phone: +34 924 289 532
  • Web: WEB

UEX

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Description

 

The purpose of this Unit is to give support for the analysis of surface composition to researchers. This facility allows a broad knowledge about the chemistry of surfaces by the combination of the information of elements presents and their coordination state, given by the XPS technique, and the molecular structure of surface provided by the ToF-SIMs equipment. Its capabilities permit to work with extended and powdered solids, including those from biological origin as cells and bacteria. The characteristics of thin films on surfaces, as thickness, composition or electrical conductivity, can be also analyzed in this unit by spectroscopic ellipsometry. In addition, calorimetric analysis can be performed to test surface reactivity on powdered solids. ITC calorimetry facility is also under the Unit scheme.

Surface analysis laboratory fulfils the ISO9001:2008 (ES050823-1).  Nanbiosis- U16-logo-ISO9001

News U16

16 Nov

Posters presentation by NANBIOSIS Units in CIBER-BBN ANNUAL CONFERENCE 2017

Last 13 and 14 of November, CIBER-BBN  has celebrated its 11th Annual Conference in Hotel Santemar in Santander. In this conference there was a poster session with the participation of the following Units of NANBIOSIS. Special mention deserves Unit 1 with Neus Ferrer as Director and  Paolo Saccardo as Coordinator (in the picture): Posters: U1. Protein Production Platform (PPP): Engineering protein complexes as nano- or micro-structured vehicles or drugs for human and veterinary medicine. Ugutz Unzueta, Naroa Serna, Laura Sánchez-García, José Vicente Carratalá, Olivia Cano-Garrido, Mercedes Márquez, Paolo Saccardo, Rosa Mendoza, Raquel Díaz, Héctor, López-Laguna, Julieta Sánchez, Anna Obando, Amanda Muñoz, Andrés Cisneros, Eric Voltà, Aida Carreño, José[...]

19 Dec

Biomedical materials that repel bacteria
Biomedical materials that repel bacteria

The magazine Viceversa dedicates a special article to María Luisa González, Professor of Applied Physics at the University of Extremadura and Scientific Director of Unit 16 of NANBIOSIS: Surface Characterization and Calorimetry Unit. One of her latest projects, PHYTECH, has developed a new surface for bone implants containing phytate, a natural product found in plant seeds that favours the regeneration of bone tissue and reduces the risk of infections in implants. Now, her research group is about to start a new European project with implant manufacturers in Austria and Lithuania, whose goal is to obtain a crystalline coating for titanium[...]

06 May

U16. Ellipsometer
A new surface for bone implants that promotes regeneration and reduces the risk of infections in which.

The Phytech project (funded by the Spanish Government through the Call INNPACTO) has recently finished with the participation of CIBER-BBN, through Unit 16 of NANBIOSIS, the University of the Balearic Islands and the companies NuMat Biomedical and Sanifit). Unit 16 of NANBIOSIS – Surface Characterization and Calorimetry, coordinated by Dr. M. Luisa Gonzalez, has conducted tests of surface composition by surface characterization techniques (XPS and ToF-SIMS) as well as the analysis microbial response of the raised surfaces in this development The results of this project have been published in the journal Applied Materials & Interfaces of the American Chemical Society.[...]

U16-Surface Characterization and Calorimetry Unit
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U17. Confocal Microscopy Service

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U17. Confocal Microscopy Service

  • Scientific Director: Prof. Juan Manuel Bellón juanm.bellon@uah.es
  • Scientific Coordinator: Gemma Pascual gemma.pascual@uah.es
  • Technical Coordinator: Mª Isabel Trabado unidad.cultivos@uah.es
  • Entities: Cell Culture Unit. Modulo IV, Planta Baja. Facultad de Medicina Universidad de Alcalá (UAH)
  • Address: Ctra. Madrid-Barcelona, km. 33,6, 28871, Alcalá de Henares, Madrid, Spain
  • Phone: +34 918 854 535
  • Web: WEB

UAH

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Description

Located in the Cell Culture Unit, Faculty of Medicine, University of Alcalá, has a room perfectly suited to host a Confocal Microscope service that provides 4 lasers and cell incubation cabin. This Unit is coordinated by Dr. Juan Manuel Bellón, PI of the Translational Research and Tissue Engineering Group at the University of Alcalá.

Services

 

FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE

U17. Services & Rates

News U17

16 Nov

Posters presentation by NANBIOSIS Units in CIBER-BBN ANNUAL CONFERENCE 2017

Last 13 and 14 of November, CIBER-BBN  has celebrated its 11th Annual Conference in Hotel Santemar in Santander. In this conference there was a poster session with the participation of the following Units of NANBIOSIS. Special mention deserves Unit 1 with Neus Ferrer as Director and  Paolo Saccardo as Coordinator (in the picture): Posters: U1. Protein Production Platform (PPP): Engineering protein complexes as nano- or micro-structured vehicles or drugs for human and veterinary medicine. Ugutz Unzueta, Naroa Serna, Laura Sánchez-García, José Vicente Carratalá, Olivia Cano-Garrido, Mercedes Márquez, Paolo Saccardo, Rosa Mendoza, Raquel Díaz, Héctor, López-Laguna, Julieta Sánchez, Anna Obando, Amanda Muñoz, Andrés Cisneros, Eric Voltà, Aida Carreño, José[...]

06 Oct

New Zealand White rabbit as a model for preclinical studies addressing tissue repair at the level of the abdominal wall.

Juan Manuel Bellón and Gemma Pascual, Scientific Director and Coordinator of Unit 17 of NANBIOSIS, have recently published an article in the prestigious journal Tissue Eng Part C Methods. Once a prosthetic material is implanted, an inflammatory reaction is induced in an attempt to remove it or isolate it from the host tissue. After this initial response, a cellular response takes place that gives rise to the start of the process of integration of the biomaterial within the host tissue. Immunohistochemical studies can provide information on the events that regulate this process, and are useful to analyze the progression of t[...]

29 Sep

Best Abstract award at the European Society for Surgical Research meeting

Verónica Gómez-Gil, collaborator in Unit 17 of NANBIOSIS and the GITBIT-UAH group (CIBER-BBN), has been the first prizewinner in the Best Abstract Competition  at the symposium “New horizons in prevention and treatment of adhesions” organized by the Dutch Adhesion Group (DAG) at the 52nd meeting of the European Society for Surgical Reseach (ESSR). The ESSR 2017 meeting was held in Amsterdam from 14th till 17th June. The title of the abstract, presented as a quick-shot presentation and a full oral during the congress, was: An experimental adhesiogenic model to evaluate histological events over time in the omentum during adhesion formation.[...]

25 Nov

U17 Nanbiosis-Best picture scientific 2014 award for Ana Belén Fernández Martínez and M. Isabel Trabado Jimenez
Best picture scientific 2014 award for Ana Belén Fernández Martínez and M. Isabel Trabado Jimenez

Ana Belén Fernández Martínez ( Dpt. Of Systems Biology . Faculty of Medicine and Health Sciences , Alcala de Henares) and M. Isabel Trabado Jimenez (CAI Medicine Biology, University of Alcalá) , have been awarded the prize “Best picture scientific 2014 ” , awarded by the Spanish Society of Biochemistry and Molecular Biology ( SEBBM ) . The winning image was published in April 2014 and has been chosen by a jury from among the three most voted in the voting online through our web -site and attending the annual meeting of the SEBBM vote. The picture titled ” larvae hatching[...]

U17-Confocal Microscopy Service
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