Nanotechnology bio applications in the clinical diagnosis II: biosensor BiMW for the early diagnosis of bacterial infections in cirrhotic patients
The peritonitis bacterial spontaneous is an infection of the fluid ascetic that has high incidence in cirrhotic patients and is associated with a high mortality. In such situation, a diagnosis early is essential for the survival of the patient. However, the identification of the causative pathogen of infection is based currently on cultivation methods that are slow and laborious.
A research coordinated by the Group of Nanobiosensors and Bioanalytical applications of the CIBER-BBN, which coordinates Unit 4 of NANBIOSIS led by Laura Lechuga, has presented the development of a biosensor interferometric based in guides bimodal (BiMW), capable of identify and quantify E. coli in liquid ascetic reaching some limits of detection below them 100 cfu /mL in only 15 min of analysis. These results demonstrate the great capacity of the biosensor BiMW as a new tool in the field clinical for the analysis microbial due to its ease use and its good relationship of cost-effectiveness and speed in the microbiological analysis.
Article of Reference: Label-free bimodal waveguide immunosensor for rapid diagnosis of bacterial infections in cirrhotic patients. Jesús Maldonado, Ana Belén González-Guerrero, Carlos Domínguez, Laura M.Lechuga. Biosensors and Bioelectronics.