Sample preparation, inclusion, section and staining for preclinical histology (paraffin and frozen samples) as well as anatomopathological evaluation.
- ADME/Tox of nanoparticles
- Study of distribution of markers of interest by immunohistochemistry.
- Study of the mechanism of toxic action (apoptosis, caspase-independent death, autophagia, necrosis).
- Preclinical toxicity assays in animal models.
Product characterization studies, solubility and other properties studies; Inmunoassay techniques; Molecular biology techniques; Cell culture techniques; Flow cytometry; Safety studies: Nervous, cardiovascular and respiratory systems; Toxicology studies; PK/PD studies, Security testing of advanced therapies using small and large animals models.