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26 Dec NANBIOSIS Unit 9 advances glioblastoma treatment with tailored copper nanoparticles, reducing tumor invasiveness and opening new therapeutic pathways. Zaragoza, December 2024. Our Unit 9, specialized in nanoparticle synthesis, has achieved a breakthrough in the fight against glioblastoma, one of the most aggressive and treatment-resistant forms of cancer. Utilizing state-of-the-art facilities and expertise, the Unit and its collaborators have developed novel copper-based nanostructures with tailored release patterns, demonstrating significant potential in inhibiting tumor progression and invasiveness. A New Paradigm in Cancer Therapy Glioblastoma (GBM) is characterized by its high invasiveness and poor prognosis. Current therapeutic options are limited by the tumor’s[...] 23 Dec Ibima-plataforma BIONAND has inaugurated an innovative radioactive facility that will advance new diagnosis and treatments through the development of radiopharmaceuticals. Malaga, December 2024. Málaga reaffirms its position as a leader in scientific innovation with the opening of a new radioactive facility, unique in Andalusia. This cutting-edge space, owned by the University of Málaga, is located within the Málaga Biomedical Research Institute and Nanomedicine Platform (Ibima BIONAND Platform), which is integrated into our Unit 28. It will facilitate the development of new drugs and therapies for treating various diseases, including cancer. Moreover, due to its exceptional features and potential, this new[...] 19 Dec Prof. Ana Paula Candiota and Prof. Silvia Lope-Piedrafita lead NANBIOSIS Unit 25, advancing MRI research and glioblastoma imaging with innovative contrast agents. Barcelona, December 2024. We are proud to announce that Prof. Ana Paula Candiota has been appointed Scientific Director and Prof. Silvia Lope-Piedrafita has taken on the role of Scientific Coordinator of Unit 25 of our ICTS. This pivotal Unit specializes in NMR and MRI biomedical applications and is jointly managed by the Universitat Autònoma de Barcelona (UAB) and CIBER-BBN. Unit 25 has a longstanding reputation for excellence in magnetic resonance imaging (MRI) research, and the recent publication titled[...] 18 Dec The BSICoS research group (Unit 27 of NANBIOSIS) shared 4 years of heart failure data from 1,000 patients on the Physionet portal for scientific use. Zaragoza, December 2024. The BSICoS research group (Biomedical Signal Interpretation and Computational Simulation) from the Aragón Institute of Engineering Research (I3A), in whcih the Unit 27 of NANBIOSIS is located, has shared a clinical database containing information from 992 heart failure patients. These patients underwent a 24-hour electrocardiogram (ECG) recording and were monitored over a four-year period. This dataset enables advancements in research on predicting the risk of sudden cardiac death using Holter monitoring data.[...] 17 Dec NANBIOSIS Unit 26 identifies biomarkers of carotid plaque vulnerability, aiding stroke prevention with advanced NMR metabolomics and collaborative innovation. Valencia, december 2024. NANBIOSIS Unit 26, one of our NMR Biomedical Applications Platforms, has once again demonstrated its essential role in cutting-edge medical research. A recent study, conducted in collaboration with multiple research institutions, identified key biomarkers associated with carotid plaque vulnerability, a critical factor in stroke risk. A Collaborative Effort in Cardiovascular Research The study analyzed metabolic differences between symptomatic and asymptomatic carotid plaques, aiming to predict which plaques are at higher risk of rupture. Using advanced nuclear magnetic resonanc[...] 10 Dec NANBIOSIS’s Protein Production Platform showcased innovations in protein engineering at PEGS Europe 2024, featuring talks, posters, and session moderation. Barcelona, november 2024. Last month, the NBT group and Unit 1 of NANBIOSIS (Protein Production Platform, PPP), from CIBER-BBN and IBB-UAB, was invited once again to participate in the prestigious PEGS Europe conference. PEGS Europe, a prestigous conference This year, the 16th PEGS Europe conference was held in Barcelona from November 5th to 7th. PEGS, or the Protein & Antibody Engineering Summit, is organized by the Cambridge Healthtech Institute (CHI) and is renowned for its focus on protein engineering and its[...] 05 Dec NANBIOSIS opens in January the 1st Competitive Open Call of 2025 for our “Cutting-Edge Biomedical Solutions” and services. Last year we opened two Competitive Calls: the first one happened in februrary 2024, and the second in june 2024. However, as a belated Christmas present, we would like to open this coming 2025 with our 1st Open Call of 2025 right away: offering you our discounts and preferential access as early as january! Our publicly funded facilities and internationally renowned scientist will help you design and test biomedical solutions to your heart’s content. We are open to all interested national and internationa[...] 25 Nov Symposium on nanomedicine vs cancer: experts gather Nov 28 in Málaga to tackle tumor-targeting challenges and advance innovative therapies. Málaga, november 2024. On November 28th at 9:00 AM, the Salón de Actos at IBIMA (C/Severo Ochoa, 35, Málaga) will host the symposium “Targeting in Nanomedicine Against Cancer,” bringing together leading experts to discuss the critical challenges and advances in applying nanomedicine to oncology. Organized by IBIMA, this event will shed light on one of the most pressing issues in cancer nanomedicine: the difficulty of delivering nanostructures to tumor cells. The challenges to overcome cancer Cancer remains one of the world’s[...] 22 Nov Prof. Jesús Santamaría, Director of NANBIOSIS Unit 9, wins the Aragón Investiga Award for his pioneering contributions to nanomaterials and research excellence. Zaragoza, november 2024. The Aragón Investiga Award for Research Excellence has been awarded to Prof. Jesús Santamaría Ramiro, a distinguished researcher and Full Professor of Chemical Engineering at the University of Zaragoza, and Scientific Director of Unit 9 of NANBIOSIS. Prof. Santamaría is the principal investigator of the Nanostructured Films and Particles group, where Unit 9 is located. He is also a key member of the Institute of Nanoscience and Materials of Aragón (INMA), a Severo Ochoa Center[...] 19 Nov NANBIOSIS will showcase its services and present the Chips R’ Us project at the 10th Anniversary CIBER Conference in Valencia, Nov 27-30, 2024. Valencia, november 2024. In cellebration of the 10th anniversary of the CIBER network, CIBER is organizing a special edition of its Scientific Conference 2024, which will take place in Valencia on November 27-30, 2024. This prestigious event, which is expected to gather over 1500 researchers, clinicians, and key stakeholders in biomedical innovation, serves as a vital platform for presenting cutting-edge scientific achievements and fostering collaborations within the Spanish research ecosystem. This year, NANBIOSIS will have a significant[...] 18 Nov The PPP advances antimicrobial peptide research, forging partnerships to combat antibiotic resistance and prevent medical device-related infections. Barcelona, october 2024. During Antibiotic Awareness Week, we spotlight the Protein Production Platform (PPP) at NANBIOSIS Unit 1 for its pivotal role in combating antimicrobial resistance. At the recent UAB Innovation Fair, the PPP showcased its cutting-edge technologies and established collaborations with experts in bacterial biofilms and nanomaterials. Together, they aim to develop innovative antimicrobial peptides as alternatives to traditional antibiotics, targeting nosocomial infections linked to medical devices. These efforts underscore the critical importance of advancing research and partnerships to address one of[...] 07 Nov The European Rare Diseases Research Alliance (ERDERA) kicked off last month, with an estimated budget of 380 million euros and the aim of improving the lives of 30 million rare disease patients in Europe and beyond. Paris, october 2024. The European Rare Diseases Research Alliance (ERDERA), a new initiative under Horizon Europe, has officially launched with an ambitious mission to improve the lives of 30 million people affected by rare diseases across Europe and beyond. Backed by a budget of €380 million, ERDERA brings together more than 170 organizations from the public and private sectors, led by the National Institut[...] 23 Oct José Amable Bernabé, Technical Coordinator of Unit 6, hosted a course on “Characterization techniques for particulate materials”. Barcelona, october 2024. For yet another year, José Amable Bernabé, of the Soft Materials Service at ICMAB and Technical Coordinator of NANBIOSIS Unit 6, offered this course. The course was an explanation of different techniques to characterize nanoparticles and particulate matter, including the fundamentals of these techniques, sample preparation, practical examples and results interpretation. The course is offered every year through the CSIC training courses offered every year for all its staff, as reported in ICMAB webpage. Soft Materials Service The Soft Materials Service provides[...] 21 Oct Chips R’ Us, a pediatric respiratory infection study, wins CIBER’s Young Researcher Call, developing an innovative lung model using Organ-on-Chip technology. Vigo, october 2024. The project Chips R’ Us, focused on studying lower respiratory infections in pediatric patients, has been selected in the 2024 Call for Intramural Projects for Young Researchers of the Biomedical Research Networking Center (CIBER). An evaluation board composed of specialists from various CIBER thematic areas evaluated the proposals based on their novelty, feasibility, interdisciplinary collaboration, and potential social impact. Led by Dr. Gabriel Alfranca, a researcher in the area of Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN) at[...] 18 Oct Prof. Ramón Martínez Máñez wins the 2024 National Research Award for his work in nanotechnology, drug delivery systems, and biomedical, environmental sensors. Valencia, october 2024. Prof. Martínez Máñez has been honored with the “Juan de la Cierva” National Research Award for the impact of his scientific career and its transfer in the field of chemistry, specifically in nanotechnology for controlled release systems and their use in sensors for medical, environmental, and agricultural applications. The evaluators also highlighted the high number of patents obtained and licensed by the awardee and emphasized the number of companies he has created, one of whic[...] 10 Oct The Nanobiotechnology Group and NANBIOSIS PPP have created a poster-guide for recombinant protein cloning, production, and purification in prokaryotic systems. Barcelona, october 2024. The Nanobiotechnology Group, led by Prof. Villaverde, in collaboration with the NANBIOSIS Unit 1, Protein Production Platform (PPP), directed by Dr. Ferrer-Miralles, has created an in-depth guide in the form of a poster that compiles key strategies for cloning, production, purification, and characterization of recombinant proteins expressed in prokaryotic systems. Drawing from their vast experience in the field, they have meticulously outlined techniques and best practices to address common challenges and optimize every stage of the process.[...] 09 Oct Directors of Unit 20 and Unit 3, Ibane Abasolo and Miriam Royo, show us the ReachGlio project, which uses nanomedicines to slow glioblastoma growth by targeting tumors in the brain, improving drug delivery through nanoparticles. Barcelona, october 2024. Each year, on October 9th, Nanotechnology Day is celebrated, a discipline dedicated to understanding and utilizing matter at a nanometric scale for purposes such as industrial or medical applications. Nanotechnology plays a fundamental role in many research lines developed at the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) and the Vall d’Hebron Research Institute (VHIR). “Our goal is to propose one or more clinical trials in[...] 09 Oct Dr. Neus Ferrer explores nanotechnology in protein research to combat antimicrobial resistance, focusing on innovative solutions using lysins and other recombinant proteins. Barcelona, October 2024. In celebration of Nanotechnology Day, we take a closer look at the cutting-edge work of Dr. Neus Ferrer, director of the Unit 1, Protein Production Platform (PPP), at NANBIOSIS. Specializing in recombinant protein synthesis, Dr. Ferrer’s research tackles critical challenges in healthcare, particularly antimicrobial resistance, often referred to as the “new pandemic”. Through advanced nanotechnology approaches, her team in develops innovative solutions that could revolutionize treatment options in biomedicine and beyond. The interview begins… Interviewer:[...] 25 Sep On World Pharmacists’ Day, NANBIOSIS Units highlighted for breakthroughs in pulmonary drug delivery and cancer research, advancing treatments for respiratory diseases and brain cancer. Barcelona and Zaragoza, September 2024. On World Pharmacists Day, we celebrate the vital contributions pharmacists make, not only in patient care but also in groundbreaking research that is shaping the future of healthcare. This year 2024, we want to give this significant date a little twist: by showcasing a few examples of how our Units are contributing to healthcare and new pharmaceutical approaches. Two key NANBIOSIS units —Unit 9 and Unit 25— are at the forefront[...] 11 Sep Researchers are advancing gene therapies for cystic fibrosis using non-viral delivery methods, focusing on patient needs and innovative treatments. Basque Country, September, 2024 – As the world comes together to mark World Cystic Fibrosis Day, from NANBIOSIS we want to highlight the collaborative efforts between our Unit 10 “Drug Formulation” (U10), the University of the Basque Country, and the Cystic Fibrosis Patient Association of the Basque Country (Arnasa) in the fight against this genetic condition. Together, our institutions are advancing the development of gene therapies aimed at treating this life-threatening hereditary disease. Gene Therapy: A new frontier in treating Cystic[...] 09 Sep Vasque Country, September, 2024 – In this interview, Lucía Enríquez, a PhD researcher at NANBIOSIS Unit 10, discusses her work on gene therapies for cystic fibrosis, a genetic disease that mainly affects the lungs. Her research focuses on using non-viral vectors to deliver gene-editing tools, like Prime Editing, a variation of CRISPR-Cas9, to correct mutations at the genetic level. Lucía explains the advantages of non-viral vectors, such as avoiding immune responses and offering safer, non-invasive treatment options. She also highlights the importance of interdisciplinary collaboration, particularly in her work at NANBIOSIS, where advanced drug formulation and pulmonary delivery systems ar[...] 27 Jun Madrid, June, 2024 – In a distinguished ceremony held at the Spanish Royal National Academy of Pharmacy (Real Academia Nacional de Farmacia), Professor Jose Luis Pedraz Muñoz, a prominent figure at the University of the Basque Country, was officially inducted as an “Académico de Número”. The highest position within the Royal National Academy of Pharmacy. Professor Pedraz, who is also a member of the CIBER-BBN and Director of Unit 10 of NANBIOSIS, took possession of “Medal Number 16”. The honor of becoming an “Académico de Número” is a prestigious recognition, from which there can only be a maximum of 50[...] 21 Jun Barcelona, June 21, 2024 – Prof. Pilar Marco has been appointed as the new head of the Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN) thematic area at the Centro de Investigación Biomédica en Red (CIBER). This prestigious appointment was confirmed during the CIBER Governing Board meeting held on June 20, 2024. Prof. Marco succeeds Ramón Martínez, bringing a wealth of expertise and a distinguished track record in biomedical research for more than a decade. Prof. Marco is a research professor at the Consejo Superior de Investigaciones Científicas (CSIC), specifically at the Institute of Advanced Chemistry of Catalonia (IQAC) in Barcelona. Additionally, s[...] 29 May Tomorrow, on the 30th of May, our Tissue & Scaffold Characterization Unit 13 organises the Conference “Understanding cardiovascular disease by means of Computation Fluid Dynamics” by Prof. Shirley Jansen. The event will take place at 12:30 in the I3A Seminar Room, Block 5, 2nd floor of the R&D Building in Campus Rio Ebro of Universidad de Zaragoza. Prof. Jansen is passionate about the importance of working alongside engineers to understand the mechanics behind many vascular pathologies such as aortic aneurysm, dissection, and peripheral arterial disease, and why close collaboration via a shared language of haemodynamics can shed light on risk[...] 16 May A new project with the participation of NANBIOSIS Unit 20 pioneers thermosensitive hydrogels for localized ovarian cancer treatment, minimizing side effects and enhancing efficacy. May 2024, VHIR/FVPR/CIBER-BBN (Barcelona). As the world recently commemorated Ovarian Cancer Day, from NANBIOSIS we proudly highlight the groundbreaking work of our collaborators in the fight against this deadly disease. Ovarian cancer stands as the seventh leading cause of cancer-related deaths, with Europe bearing the brunt of its impact, recording over 44,000 fatalities annually. In a bid to revolutionize treatment paradigms and enhance patient outcomes, researchers at the Clinical Biochemistry, Drug Delivery and Therapy (CB-DDT) Group,[...] 15 May NANBIOSIS opens in June the 2nd competitive open call 2024 for our “Cutting-Edge Biomedical Solutions” and services. Our publicly funded facilities and internationally renowned scientist will help you design and test biomedical solutions to your heart’s content. We are open to all interested national and international users who may come either from the public or the private sector. You can apply to use our services in two modalities: under the “Competitive Open Access” (within two designated calls) or by “Access on Demand”, your choice. To make that happen, at least 20% of the NANBIOSIS Units’ capacity is granted on t[...] 08 May Do not miss the chance to join our hands-on XV Workshop of Theoretical-Practical Training in MRS / MRI, with specific application in laboratory animals Our excellent teacher Dr. Silvia Lope will be at the helm in this practical workshop. And it provides all the required skills users need to operate our fantastic Biospec, available as a service in our Unit 25. The registration period for the “XV Workshop of Theoretical-Practical Training in Spectroscopy and Magnetic Resonance Imaging (MRS / MRI): Application in Laboratory Animals” is still open until May the 17th, 2024. This workshop is organized by the Department of[...] 09 Apr The prestigious journal Nano Letters published the work led by NANBIOSIS researchers, affiliated with Unizar, INMA (CSIC-UNIZAR), CIBER–BBN, and IIS Aragón. The successful development of this innovative treatment approach was possible through the efforts of our Unit 9, led by Prof. Santamaría and Dr. Hueso, both corresponding authors of the publication. As recently announced by Universidad de Zaragoza (Unizar), a team led by NANBIOSIS researchers at the Instituto de Nanociencia y Materiales de Aragón (INMA, a joint institute of CSIC and UNIZAR) has discovered a way to artificially conduct a new chemical reaction, called transamination. This approach can act within[...] 04 Apr Breakthrough colorectal cancer treatment unveiled by NANBIOSIS Units promises enhanced precision & efficacy in targeted cancer therapies. March 2024, UAB/Institut de Recerca Sant Pau/CIBER-BBN (Barcelona) As we leave World Colorectal Cancer Day 2024 behind, marked on March 31st, there have been significant highlights in cancer treatment, a field in which targeted therapies are playing a crucial role. In this context, researchers from the Nanobiotechnology team, at the Institut de Biotecnologia i de Biomedicina from Universitat Autònoma de Barcelona, led by Prof. Antonio Villaverde, in collaboration with the Oncogenesis and Antitumor Drugs team led by Prof. Ramón Mangues at Institut d[...] 19 Mar Strategic funding of 1,8M€ elevating Spanish research infrastructure to forge a path of innovation and resilience. March 19th 2024, NANBIOSIS As already announced at the end of last year, from NANBIOSIS we are poised for a groundbreaking leap forward thanks to a 1,800,000€ injection of European funding. This funding has recently materialized in a significant improvement and update of the equipment and services of NANBIOSIS Units. The Spanish Government’s Recovery, Transformation, and Resilience Plan (Plan de Recuperación, Transformación y Resiliencia – PRTR) stands as a beacon of hope amid the challenges brought forth by the COVID-19 crisis. This comprehensive roadma[...] 11 Mar Discover cutting-edge technologies in tissue engineering, drug delivery systems, and biodegradable implants. March13th 2024, online event From NANBIOSIS we are pleased to announce the Presentation Day of Health Technologies by the MATERPLAT Health Innovation Group, which will take place on March 13th at 11:00 a.m. in an online format. During this event, cutting-edge technologies being developed by MATERPLAT members in these three areas will be presented:* Gels as scaffolds for tissue engineering.* Biomimetic and/or biointeractive systems for controlled release of drugs or bioactive molecules.* Biodegradable implants adapted to tissue and bone growth. The objective of the event is to showcas[...] 08 Mar Our interview series delve into the journeys of 7 female researchers, their challenges, and the call for gender equality in science, inspiring the next generation. March 8th 2024, NANBIOSIS (Spain) Kicking off on 11F “International Day of Women and Girls in Science” 2024, and spanning all the way until Woman’s Day 2024, our interview series has aimed to highlight the life, career and opinions of some of the brilliant minds within our network. Today is time to wrap it up, and for this reason we present you a summary of each of them and a chance to take a deeper[...] 08 Mar NANBIOSIS is a Research Infrastructure for Biomedicine made up of the Platforms of the Center for Centro de Ivesntigación Biomedica en Red (CIBER- in the area of Bioengineering, Biomaterials, and Nanomedicine -CIBER-BBN), the Preclinical Infrastructure and the Development of Minimally Invasive Technologies, of the Jesús Usón Minimally Invasive Surgery Center (CCMIJU) and the Nanoimaging unit of the Biomedical Research Institute of Malaga-Nanomedicine Platform (IBIMA-BIONAND Platform). NANBIOSIS as part of the Spanish Map of ICTS (an acronym for “Scientific and Technical Unique Infrastructures” in Spanish), approved by the Ministry of Science and Innovation, is open to all interested national and international users who[...] 05 Mar This novel immunization platform, recently published in ACS, triggers potent antivirus response, promising efficient and cost-effective vaccination. March 2024, UAB/Vall d’Hebron Research Institute/CIBER-BBN (Barcelona) The battle against infectious diseases demands innovative solutions. The world is especially aware of this fact after facing threats such as the SARS-CoV-2 pandemic. In a very recent publication in ACS Materials Letters, researchers from the Universitat Autònoma de Barcelona (UAB) and Hospital de Sant Pau, both within the CIBER-BBN, have achieved a significant milestone in vaccine development. Their study, conducted in partnership with international teams as well as NANBIOSIS, has introduced a novel immunization approac[...] 04 Mar Dr. Mincholé discusses cardiac risk assessment, gender challenges in science, and the transformative potential of Digital Twins in healthcare research. This is part of a series of interviews to several female researchers within the context of International Day of Women and Girls in Science 2024 and Woman’s Day 2024. For more interviews, visit our news section here. March 2024, I3A-Unizar, Zaragoza (Spain) The meeting room of the High Performance Computing cluster is a comfortable place. A whiteboard full of diagrams occupies a good portion of one of the side walls, creating a welcoming atmosphere where complex concepts become accessible. In[...] 01 Mar Dr. Vílchez, our esteemed colloidal chemistry researcher, discusses her focus on water-in-water emulsions and microcoacervates. She highlights gender biases in science and advocates for inclusivity and recognition of women’s contributions. This is part of a series of interviews to several female researchers within the context of International Day of Women and Girls in Science 2024 and Woman’s Day 2024. For more interviews, visit our news section here. March 2024, IQAC-CSIC, Barcelona (Spain) Dr. Susana Vílchez, an esteemed researcher in colloidal chemistry, and the technical and quality manager of Unit 12 of NANBIOSIS, offers a profound insight into her research endeavors[...] 01 Mar NANBIOSIS researchers pioneer novel treatments for Lysosomal Storage Diseases utilizing extracellular vesicles and liposomes, offering hope to patients. 1 March 2024, Vall d’Hebron Research Institute/ICMAB-CSIC (Barcelona) Lysosomal Storage Diseases (LSDs) encompass a group of rare disorders caused by mutations in lysosomal proteins. These mutations can lead to dysfunctional proteins responsible for breaking down cellular materials, resulting in the accumulation of deposits. Such accumulations can manifest in various neurological symptoms, ranging from progressive neurodegeneration to severe cognitive impairment. Often emerging in childhood, LSDs tragically culminate in premature death for many patients. Currently, up to 14 subtypes of LSDs can be treated[...] 29 Feb NANBIOSIS introduces the new webpage of RED-DM, uniting experts to combat Myotonic Dystrophy. Highlighting Ramón Eritja’s group’s pivotal role. 29 February 2024, IQAC-CSIC (Barcelona) In a significant stride toward addressing the challenges posed by Myotonic Dystrophy, the Translational Genomics Group of the INCLIVA Health Research Institute (associated with the Valencia Clinical Hospital) and the University of Valencia (BIOTECMED Institute) have spearheaded the establishment of the Red Temática Nacional en Distrofia Miotónica tipo 1 (National Thematic Network in Myotonic Dystrophy Type 1). This progressive and degenerative disease, also referred to simply as DM1, is currently incurable and underdiagnosed. In addition, it[...] 28 Feb Researchers from IQAC-CSIC advance towards faster detection and treatment of cystic fibrosis and rare respiratory diseases, improving patient outcomes. 28 February 2024, IQAC-CSIC (Barcelona) Cystic Fibrosis (CF) is a progressive autosomal recessive disease. It is caused by a mutation in the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, disrupting its exocrine activity. While CF affects various organs, its impact on the lungs is particularly severe. This disease leads to the accumulation of thick, sticky mucus, obstructing airways and trapping bacteria, resulting in significant infections and extensive lung damage. Consequently, individuals with CF are highly susceptible to respiratory[...] 27 Feb For Rare Disease Day, we raise awareness through 2 events: 1 in Barcelona (Feb 28) & another in Madrid (Feb 29). Collaboration & research in focus. 28-29 February 2024, Rare Disease Day 2024 NANBIOSIS is actively involved in promoting awareness and understanding of rare diseases, Due to their lower incidence, these conditions are often face neglect in medical research and industrial treatment. To spotlight this crucial issue, NANBIOSIS is pleased to announce its participation in two significant events coinciding with Rare Disease Day celebrations. These events will address various aspects of rare and minority diseases research and treatment. Event 1:[...] 26 Feb Our expert in nanocarriers talks about her journey from biotechnology to cancer therapy, an example of passion and perseverance in science. February 2024, I3A/CIBER-BBN, Zaragoza (Spain) The silence of the meeting room is only broken by the constant purring of the heating system. A large square table made of dark wood fills the entire room almost completely. Its dimensions are too extensive for anyone to reach its center. One may wonder, how many passionate conversations about the next step to take in countless research projects have been witnessed by these four walls? The door swings open briskly, and a familiar[...] 22 Feb Prof. Peña gives us her insightful point of view in overcoming challenges, embracing passion, and cultivating collaborative success towards career estabilization. February 2024, Unizar/CIBER-BBN, Zaragoza (Spain) The echo of our footsteps returns from the high ceilings filled with electrical conduits and gas pipes. An alarm sounds in the distance, while the warmth of the Zen Garden located in the center of the R&D Building reminds us once again that peace and progress will never be at odds. We continue forward across the maroon floor, towards one of the access gates that separate each wing of the building. After crossing it,[...] 21 Feb Nearly 40 scientists across 7 countries are pioneering this breakthrough in wound healing using a nobel and affordable bio-inspired, anti-bacterial matrix. In addition to the vast consortium, the project also comprises 5 small and medium-sized enterprises (SMEs) and 9 academic institutions. These were convened last February at the University of Granada to share insights, progress, and strategies. According to an article published by UGR at the beginning of this month, about 40 researchers involved in the project have attended a meeting to share results and progress. The Horizon Europe project NABIHEAL, coordinated by the Biomedical Research Networking Center (CIBER) at[...] 19 Feb We ask Dr. Martín about her innovations in cancer treatment with nanoparticles, in the context of her collaborations with NANBIOSIS. This is part of a series of interviews to several female researchers within the context of International Day of Women and Girls in Science 2024 and Woman’s Day 2024. For more interviews, visit our news section here. February 2024, INMA-CSIC/CIBER-BBN, Zaragoza (Spain) We are walking through the tall corridors that connect the numerous blocks of the large R&D Building, located near the Río Ebro Campus of Unizar. This building is a conglomerate of institutes, laboratories, and research groups. In its[...] 15 Feb Anna Aviñó speaks about her journey as a researcher and her captivating oligonucleotides. This is part of a series of interviews to several female researchers within the context of International Day of Women and Girls in Science 2024 and Woman’s Day 2024. For more interviews, visit our news section here. February 2024, IQAC-CSIC/CIBER-BBN, Barcelona (Spain) Could you share with us a bit about your research area and the projects you are currently working on? I am a chemist specializing in nucleic acid chemistry. These compounds are wonderful, I would say unique; not only do they contain genetic information, but they[...] 12 Feb NANBIOSIS researchers reach intracellular targets with encapsulated antibodies. February 2024, IQAC-CSIC/CIBER-BBN, Barcelona (Spain) and Santiago (Chile) Dr. Abasolo and her team have developed an innovative strategy to combat intracellular oncogenes, notably KRAS, implicated in various deadly cancers. By encapsulating therapeutic antibodies within polymeric micelles, they have successfully facilitated the entry of these antibodies into cancer cells, targeting internal markers. This breakthrough, achieved through international collaboration, represents a significant advancement in cancer treatment and holds promise for addressing other diseases with intracellular targets. These findings provide hope for improved therapies and outcomes in cancer and beyond. Every individual is said to[...] 11 Feb In celebration of the International Day of Women and Girls in Science 2024, NANBIOSIS proudly presents a series of insightful interviews featuring some of our most esteemed female researchers and collaborators. As we commemorate this important day, join us in honoring the achievements of these remarkable individuals, as they share their perspectives, challenges, and triumphs in the pursuit of scientific excellence. Explore our news section for more inspiring interviews, and discover the diverse talents driving innovation within NANBIOSIS and beyond. Drs. Anna Aviñó, Fany Peña, Ana Martín, María Sancho, Susana Vilchez, Ana Mincholé and, of course, Dr. Elisabeth Prats, a[...] 07 Feb NANBIOSIS Researchers Lead the Way in Innovative Nanomedicine Approaches Cancer remains a formidable challenge globally, with 19.1 million cases diagnosed in 2020, resulting in nearly 10 million deaths. However, amidst these alarming statistics, a beacon of hope emerges from the field of nanomedicine. Spearheaded by Professor Jesus Santamaria and his team at the NFP group, part of the NANBIOSIS ICTS Unit 9, groundbreaking advancements in nanotechnology are revolutionizing cancer treatment. Funded by the European Research Council, their efforts mark a significant stride towards more effective and targeted therapies. “The potential adverse effects (of antineoplastic agents) on healthy cells is t[...] 06 Feb DNA nanoparticles to selectively target tumor tissues through precise control of the synergies between transported drugs. February 2024, IQAC-CSIC/CIBER-BBN, Barcelona. The team led by Drs. Carme Fàbrega and Ramón Eritja, in close collaboration with 3 units of the NANBIOSIS ICTS, has developed a new strategy to improve the efficacy and reduce the toxicity of anticancer drugs. They have chemically linked several cytotoxic drugs, currently used in the treatment of various types of tumors, to DNA nanostructures. These structures selectively target cancerous tissues through folate receptors. This tactic allows precise control of drug concentration and exploits their combined effect. The results[...] 15 Jan NANBIOSIS opens in February the 1st competitive open call 2024 for its “Cutting-Edge Biomedical Solutions” and services. NANBIOSIS is a research infrastructure for Biomedicine in which three cutting-edge public institutions collaborate forming a deeply interconnected laboratory network: CIBER-BBN, CCMIJU and IBIMA-Plataforma BIONAND. In addition, NANBIOSIS is part of the Spanish Map of ICTS (Spanish for “Scientific and Technical Unique Infrastructures”), approved by the Spanish Ministerio de Ciencia, Innovación y Universidades . Our publicly funded facilities and internationally renowned scientist will help you design and test biomedical solutions to your heart’s content. We are open to all interested national and internationa[...] 27 Dec NANBIOSIS Unit 1 Protein Production Platform (PPP) of CIBER-BBN and UAB, has taken a significant step towards enhancing its service capabilities in the field of recombinant protein production and purification. Until now, due to space constraints at the Institute of Biotechnology and Biomedicine (IBB), U1’s activities were confined to half of a small laboratory. However, thanks to the ongoing commitment of the center to bolster the PPP’s activities, this unit has gained access to a laboratory, along with an office, exclusively designated for the platform within the IBB premises, creating an optimal environment for the process of protein production and[...] 20 Dec With the participation of two units of NANBIOSIS ICTS and the expertise of the scientists managing these units The study, fruit of the collaboration between the Nanotechnology group of the Institute of Biotechnology and Biomedicine (IBB-UAB), led by Prof. Antonio Villaverde, and the Oncogenesis and Antitumor Drugs group of the Sant Pau Research Institute, led by Dr. Ramon Mangues, both members of CIBER-BBN, has made significant progress by identifying the natural ligand PDGFD as an effective tool to target protein nanoparticles to tumor-associated fibroblasts that overexpress the PDGFR-β receptor. Given the relevance of the discovery, this technology has been intellectually[...] 30 Nov *Image explained by Merce Márquez Martínez, Coordinator of NANBIOSIS U1 The NBT group and Unit 1 of NANBIOSIS (Protein Production Platform, PPP), from CIBER-BBN and IBB-UAB, participated in the 15th PEGS Europe conference held in Lisbon from November 14th to 16th. PEGS, or the Protein & Antibody Engineering Summit, is a prestigious conference, organized by the Cambridge Healthtech Institute (CHI), focusing on protein engineering and its applications in drug discovery, development, and delivery. This conference serves as a valuable platform for knowledge exchange among researchers, scientists, industry experts, and professionals in the field of protein science. From left to right,[...] 24 Nov During 20-22 of November 2023, the III PTI+Global Health Scientific Conference were held in the Center for Human and Social Sciences, in Madrid. In March 2020, the CSIC (Spanish National Research Council) launched the the Interdisciplinary Thematic Platform (PTI) on Global Health to bring together research teams and enhance knowledge about the new coronavirus SARS-CoV-2, which caused the pandemic. The PTI has mobilized and coordinates more than 400 scientists from 50 CSIC institutes in all areas. The annual PTI+Global Health Scientific Conference are a meeting space where the results of the research carried out in the laboratories can be shown[...] 16 Nov – It is possible to achieve an administration method that improves the effectiveness and increases the safety of drugs for chronic liver disease? -Yes, with nanoparticles! – How? To find an answer, was created the european project NANOSIM (Biodegradable nanoparticles of Simvastatin as new therapeutic tool for chronic liver disease financed in the Joint Transnational Call (2018) led by the Hospital Vall d´Hebron. A translational research proposed as an approach for its use in patients. Until now, the only therapeutic option for patients is to eliminate the etiological agent (or the external promoter of damage), whether it is a virus,[...] 13 Nov On Thursday, November 2, the Female Talent Award, in the category of Women and Science, was awarded to Rosa Hernández from the NanoBioCel group of CIBER BBN and the U10 Drug Formulation Unit. The award is given by AMPEA (Association of Professional and Business Women of Alava). In her award speech, Rosa Hernández, highlighted that the effort and work carried out during all these years has allowed the research group to develop cutting-edge research and to place the names of the University of the Basque Country (UPV/EHU) and Vitoria-Gasteiz on the map of cutting-edge research in Nanotechnology and Regenerative Medicine.[...] 08 Nov 2023 CIBER-BBN Annual meeting has taken place at Santemar Hotel, in Santander during November 6-7. This year the format of our annual conferences has been changed towards a collective event scheme between the CIBER-BBN and CIBEREHD thematic areas. On Monday 6 the scientific sessions werecommon for EHD and BBN, with appealing contents for the mixed audience. On Tuesday 7 EHD and BBN sessions will specific for each area in separate rooms (with common coffee break). Posters of both areas were on display in the exhibit hall throughout the entirety of the Annual Meeting. Moreover, at the “Posters & beers” session (Monday[...] 08 Nov The annual conference of the scientific áreas of CIBER (the most important Centre for Biomedical Research in Spain) are hotly awaited every year for the CIBER community as a foro to be updated about emerging key technologies and discuss about research lines and results, find new opportunities to collaborate and join efforts towards common objectives. Moreover, this year, the Annual Conference of CIBER-BBN (Bioengineering, Biomaterials and Nanomedicine) has been organized as a collective event scheme together with the scientific area of CIBEREHD (Digestive and Liver Diseases). Both areas have already shared experiences of collaborative projects, demonstrating the complementarity of their fields.[...] 02 Nov Deadline: 16/11/2023 If you are a Scientist and a passionate Communicator eager to develop your own ideas and strategy, keep reading! The biomedicine consortium CIBER, is looking for a Ph.D. in science to develop the Communication Plan of the ICTS NANBIOSIS. You will have the opportunity of working with top level researchers in the areal of biomaterials, bioingeniering and nanomedicine in a diverse and inclusive team working directly with the Coordinator of NANBIOSIS and the project manager team of CIBER-BBN Applications must be filed at CIBER’s web portal untill November 16th. We look for a Science Degree (Biology, Biotechnology, Biochemistry or similar),[...] 27 Oct The Service-SOFT/U6 Nanbiosis ICTS (of CIBER-BBN and ICMAB-CSIC) together with the company NANE are organising a technical seminar on materials characterisation equipment. In this seminar, different techniques for the characterisation of particulate materials such as DLS, NTA, Laser Diffraction, Morphology will be discussed. Limited places. You can register at this link Link to the program: here Date: 08th of November Place: Institute of Materials Science of Barcelona (ICMAB) -CSIC – Conference room[...] 23 Oct On October 17, 2023, the NANBIOSIS U1 of Protein Production Platform PPP, took part in the UAB Innovation Fair, where various research groups, spin-offs, service providers, research centers, and companies gathered to foster networking opportunities. This event proved highly advantageous for the PPP, as it not only facilitated the identification of potential new clients but also paved the way for collaborative efforts aimed at enhancing and refining the final product offered by the PPP. PPP NANBIOSIS U1 Scientists at PPP stand at the Fair: Neus Ferrer, Scientific Director; Rosa Mendoza, Laboratory Manager, and Mercedes Marquez, Scientific Coordinator. The UAB Innovation[...] 20 Oct Today, Bonnie Bassler, Jeffrey Gordon, and Peter Greenberg are receiving the Princess of Asturias Award for their contribution to the knowledge of the role of the human microbiome and the bacteria Quorum Sensing. Targeting Quorum Sensing allows understanding of bacteria behaviour and pathogenesis, but also developing new therapeutic and diagnostic strategies for infectious diseases. Bonnie Bassler has shown how small chemical signals are involved in such a communication process. Peter Greenberg was one of the first scientists who assigned the term Quorum Sensing (QS) to such a sophisticated system used by bacteria to communicate and synchronize behavior. He was involved[...] 15 Oct On the 20th of October, CIBER-BBN group NanoBioCell – NANBIOSIS U10 Drug Formulation unit organises the Conference “Developping support technologies for adressing traslational gaps in regenerative medicine” by Dr. James-J Yoo. The Conference will take place in the Assembly hall of the Faculty of Pharmacy on Friday 20th of October, 2023 from 12:00 to 13:00, as part of the JRL program Advanced Pharma Development. The Conference will be broadcasted. Dr. Yoo is Professor and Associate Director of the Wake Forest Institute for Regenerative Medicine (WFIRM), with cross-appointments to the Departments of Urology, Physiology and Pharmacology, Clinical and Translational Science Institute,[...] 02 Oct Researchers of CIBER-BBN group NanoBioCell – NANBIOSIS U10 Drug Formulation unit Jose Luis Pedraz Muñoz, Laura Saenz del Burgo Martínez, Gustavo Puras Ochoa, Jon Zarate Sesma have edited the book “3D Printing and Bioprinting for Pharmaceutical and Medical Applications” The increasing availability and decreasing costs of 3D printing and bioprinting technologies are expanding opportunities to meet medical needs. 3D Printing and Bioprinting for Pharmaceutical and Medical Applications discusses emerging approaches related to these game-changer technologies in such areas as drug development, medical devices, and bioreactors. Key Features: Offers an overview of applications, the market, and regulatory analysisAnalyzes market research of 3D printing and bioprinting technologiesReviews[...] 25 Sep Carlos Rodriguez-Abreu, Scientific Director of NANBIOSIS U12 Nanostructured liquid characterization unit gave a Keynote presentation entitled “Chromonic liquid crystal emulsions” at the European Colloid and Interface Society ECIS 2023 conference held in Naples, Italy (September 3-8, 2023) . Chromonic liquid crystals (CLC) can be used as templates for material synthesis and, since some CLC are nontoxic and water-based, they are also interesting for biological and medical applications. The presentation included a summary of experimental results on internally structured emulsions made of CLC encapsulated in droplets, that feature various complex morphologies. Photothermal, sensing and imaging applications are envisaged.[...] 31 Aug CIBER-BBN´s and NANBIOSIS 2023 Annual Conference will be celebrated in November 6-8, 2023 in Santander This year we change the format of our annual conferences towards a collective event scheme between the CIBER-BBN and CIBER-EHD thematic areas. Our objective is to create a two-day conference that stimulates scientific collaborations and explores new lines of research. Both areas have already shared experiences of collaborative projects, demonstrating the complementarity of their fields. The results of these seed projects will be presented on the first day. In addition, we are pleased to announce that there will be a new edition of seed collaborativ[...] 18 Jul Scientists of NANBIOSIS Unit 8 have participated in the publication of a a comprehensive experimental review of inks, paper substrates, and printing techniques. The objective is to offer the scientific community a guide with data to facilitate the design of printed devices and manufacture them in an ecological way. Gemma Gabriel, researcher of Biomedical Applications Group at IMB-CNM and last author of the article, highlights the applications of the results in health monitoring, with non-invasive techniques such as glucose detection, although there are many applications where printed electronic materials and technologies are very useful. Among them, environmental monitoring, (in air[...] 17 Jul Today has been published the Resolution of the Presidency of the State Research Agency of the Spanish Ministry for Science and Innovation granting fund for the selected projects in the 2022 call for “RESEARCH NETWORKS” within the framework of the State Program to Promote Scientific-Technical Research and its Transfer, of the State Research Plan Scientific, Technical and Innovation The final resolution proposal was issued on June 21, 2023, once the hearing process has been completed and prior acceptance by the interested parties. The two years lasting project 2021-2023RED2022-134685-I “NANBIO-ACCESS” was among the selected proposals. The main goals pursued by t[...] 16 Jul NANBIOSIS is a Research Infrastructure for Biomedicine made up of the Platforms of the Center for Centro de Ivesntigación Biomedica en Red (CIBER- in the area of Bioengineering, Biomaterials, and Nanomedicine -CIBER-BBN), the Preclinical Infrastructure and the Development of Minimally Invasive Technologies, of the Jesús Usón Minimally Invasive Surgery Center (CCMIJU) and the Nanoimaging unit of the Biomedical Research Institute of Malaga-Nanomedicine Platform (IBIMA-BIONAND Platform). NANBIOSIS as part of the Spanish Map of ICTS (an acronym for “Scientific and Technical Unique Infrastructures” in Spanish), approved by the Ministry of Science and Innovation, is open to all interested national and international users who[...] 12 Jul Jesús Santamaría, Professor of Chemical Engineering at the University of Zaragoza, has been elected a foreign member of the Istituto Lombardo Accademia di Science et Lettere, in its division of Mathematical and Natural Sciences, Chemistry section. This institution was originally founded by Napoleon Bonaparte in 1797, as the National Institute of the Cisalpine Republic, in charge of collecting discoveries and perfecting the arts and sciences, following the model of the Institut de France. Napoleon himself appointed the first members of the Institute and its first president, Alesssandro Volta, Italian chemist and physicist, famous primarily for the discovery of methane in[...] 30 Jun NANBIOSIS, U20. In Vivo Experimental Platform, led by Dr. Ibane Ibasolo, has been updated and improved as a result of its participation in the project FICTS1420-20, selected by the MICINN for co-financing by the FEDER Program in ICTS 2014-2020 (Equipment for setting standardized immunotoxicology assays for the U20 -NANBIOSIS I17 Action of the Investment Plan-) A particle particle analyzer equipment (Exoid) has been inslalled at NANBIOSIS U20 for measurement of the concentration and the size of nanoparticles. The Exoid is the latest instrument from the Izon company to measure the physical characteristics of nanoparticles in electrolytic solution. Based on Tunable Resistive Pulse Sensing (TRPS) principles, the equipment[...] 22 Jun Researchers of the NanoBioCel research group of the University of the Basque Country (UPV/EHU) and CIBER BBN, belonging to NANBIOSIS U10 Drug Formulation, Bioaraba, and CONICET Foundation of Argentina, have collaborated in a studio entitled: “The role of microfluidics and 3D-bioprinting in the future of the exosome therapy” which has been published in the journal Trends in Biotechnology, whose editorial seeks particularly relevant articles. The importance of this publication lies in the novelty and potential of nanovesicles as new therapeutic agents and the versatility of microfluidic technology in combination with 3D bioprinting to bring nanovesicles closer to the clinic. Artic[...] 20 Jun Symposium on the occasion of the retirement of Prof. José Becerra Ratia: “40 years of the Bioengineering and Tissue Regeneration Laboratory (LABRET): tribute to Pepe Becerra” We are pleased to inform about the Symposium organized by the LABRET group (Bioengineering and Tissue Regeneration Laboratory), University of Malaga, on the occasion of the retirement of Professor José Becerra. The event will be held, only in person, on July 7 in the morning at the Faculty of Sciences of the University of Malaga Download the program. Prof. José Becerra was the Director of the Andalusian Center for Nanomedicine and Biotechnology (BIONAND) sinc[...] 12 Jun CIBER-BBN´s Annual Conference has been scheduled for November 6-8, 2023 This year, in the framework of a CIBER program to stimulate collaborations between clinical and technological groups, the conference will be organized in cooperation with a CIBER clinical area, CIBER-EHD: Hepatic and Digestive diseases. (An internal call of collaborative projects BBN-EHD will be open by). The scheme of the event will be slightly different from previous editions: On Monday 6 the scientific sessions will be common for EHD and BBN, with appealing contents for the mixed audience.On Tuesday 7 EHD and BBN sessions will be specific for each area in[...] 03 Jun On May 16 representatives of the General Subdirectorate of Large Scientific-Technical Facilities of the Ministry of Science and Innovation visited unit 16 of NANBIOSIS (created by Centro de Investigación Biomédica en Red -CIBER-, and the University of Extermadura). Mrs. Beatriz Albella Rodríguez and Mrs. María Jesús Marcos Crespo, got to know first-hand the facilities of unit 16 of the CTS NANBIOSIS of “Surface Characterization and Calorimetry“. The visit was guided by the Scientific Director of Unit 16 of NANBIOSIS, Maria Luisa González Martín, and by Mr. Javier de Francisco Morcillo, Director of the Secretariat for Scientific Infrastructure and Technological Development[...] 30 May NANBIOSIS opens in June the 2nd competitive open call 2023 for its “Cutting-Edge Biomedical Solutions” and services. NANBIOSIS is a Research Infrastructure for Biomedicine made up of the Platforms of the Center for Centro de Ivesntigación Biomedica en Red (CIBER- in the area of Bioengineering, Biomaterials, and Nanomedicine -CIBER-BBN), the Preclinical Infrastructure and the Development of Minimally Invasive Technologies, of the Jesús Usón Minimally Invasive Surgery Center (CCMIJU) and the Nanoimaging unit of the Biomedical Research Institute of Malaga-Nanomedicine Platform (IBIMA-BIONAND Platform). NANBIOSIS as part of the Spanish Map of ICTS (an acronym for “Scientific and Technical Unique Infrastructures” in[...] 26 May Next Friday, June 9, 2023, a Workshop on Oncological Hyperthermia entitled “Clinical Implementation of Oncological Hyperthermia in Spain and Europe: current situation and prospects” will be held in Barcelona. The location of the event is at the Hotel Front Marítim in Barcelona and the scheduled time is from 9:00 a.m. to 5:30 p.m. Relevant speakers will present an updated vision on the different modalities of hyperthermia that are being used for cancer treatment. Jorge Contreras (Coordinator of the Spanish Society of Radiation Oncology ) will give a session on the current situation of clinical hyperthermia in Spain. Daniel Ortega (Coordinator[...] 15 May Nb4D has a new look on line! Nb4D Group (of IQAC-CSIC and CIBER-BBN) has lunched a new website “Revolutionsising Diagnosis“ with the aim to facilitate a faster and easier navigation througth their “pioneering research to develop new diagnostic and therapeutic approaches” and their solutions and expertise to help researchers and companies. Antibodies, bioreceptors, hapten design and synthesis, immunoanalytical method development, new ivd tools, surface functionalization, therapeutic antibodies and much more knowledge and expertise revolutionising diagnosis. The new website contains a page for CAbS-NANBIOSIS. Custom Antibody Service (CAbS), unit 2 of the ICTS NANBIOSIS[...] 12 May The website for NABIHEAL, an EU-funded Horizon Europe project developing biomaterials for complex wound healing, is now online. The Horizon Europe project NABIHEALi project is coordinated by the Center for Biomedical Research Network (CIBER) at the Institute of Materials Science of Barcelona (ICMAB-CSIC). This project will apply one the “Cutting Edge Biomedical Solutions” of NANBIOSIS for the preparation of different nanoestructures with antimicrobial properties, required for the development of the final multifunctional wound healing biomaterials. This case will gather the expertise of two NANBIOSIS unit: NANBIOSIS U6 will produce and characterize these nanoestructures with antimicrobial properties, which will be tested in NANBIOSIS U16. Find out mor[...] 28 Mar The event brought together high-level experts from 3 continents in the field of nanotechnology. Barcelona, March 27th, 2023 The EU funded project Safe-n-MedTech celebrated its official 48th Month Management Committee Meeting on March 7th to 9th 2023 with a private event taking place in Lisbon. The event was organized and hosted by Instituto Medicina Molecular João Lobo Antunes (IMM), who are partners in this project. The Consortium had the pleasure to count with the virtual attendance of the Project Adviser, Ozlem Cangar (HADEA), who could follow the critical aspects of the project progress. The meeting was opened by Ángel d[...] 24 Mar NANBIOSIS unit 16 Surface Characterization and Calorimetry Unit form CIBER-BBN and University of Extremadura has recently incorporated new equipment acquired through the execution of the project FICTS1420-14-09, cofinanced with FEDER funds, the Ministry of Economy and Competitiveness and Junta de Extremadura, Regional Ministry of Economy, Science and Digital Agency. A new FlexPS-ARPES-E kit, manufactured by SPECS, is now available for use by researchers This new resource uses the technique of photoelectron spectroscopy generated by X-rays to analyze the chemical composition of a surface. The electrons given off by the irradiated surface generate a fingerprint of the molecules that make up that surface, yielding information[...] 21 Mar The extracellular vesicles secreted by triple-negative breast cancer stem cells are markers of lung metastasis, according to a study carried out by researchers at CIBER. The work has been carried out by researchers from various CIBER-BBN groups (Bioengineering, Biomaterials and Nanomedicia), and CIBERONC (CIBER area focused on cancer) has participated in it. The research has been led by Joaquín Seras, from the Vall d’Hebron Research Institute (VHIR), a specialist in targeted drug therapies. Physicochemical EVs characterization and all the in vivo studies were performed by NANBIOSISunits of CIBER, specifically NTA analysis was carried out at Unit 6 of Biomaterial Processing[...] 20 Mar Doctor Marc Martínez from the Nanomol-Bio group – NANBIOSIS U6 from CIBER-BBN at ICMAB-CSIC, defended his PhD thesis “Nanoparticles to modulate topography and ligand distribution at the nanoscale: impact on cell behavior” on 9 March 2023 at ICMAB. he PhD thesis was supervised by Imma Ratera, Judith Guasch and Nora Ventosa from the Nanomol-Bio group at ICMAB-CSIC. Ana Paula Candiota Silveira, Scientific Coordinator of NANBIOSIS U25 was part of the Committee that evaluated the Thesis tooghether with Jesús Martínez de la Fuente, Instituto de Nanociencia y Materiales de Aragón (INMA-CSIC) (President), and Anna Lagunas Targarona, Institut de Bioenginyeria de Catalunya (IBEC) (Vocal). As[...] 15 Mar NANBIOSIS is a Research Infrastructure for Biomedicine made up of the Platforms of the Center for Centro de Ivesntigación Biomedica en Red (CIBER- in the area of Bioengineering, Biomaterials, and Nanomedicine -CIBER-BBN), the Preclinical Infrastructure and the Development of Minimally Invasive Technologies, of the Jesús Usón Minimally Invasive Surgery Center (CCMIJU) and the Nanoimaging unit of the Biomedical Research Institute of Malaga-Nanomedicine Platform (IBIMA-BIONAND Platform). NANBIOSIS as part of the Spanish Map of ICTS (an acronym for “Scientific and Technical Unique Infrastructures” in Spanish), approved by the Ministry of Science and Innovation, is open to all interested national and international users who[...] 28 Feb Today is the international day of rare diseases, a day to raise awareness and instigate change for people living with a rare disease. From NANBIOSIS we want to sume to this celebration and higtligh our commitment to helping people with rare diseases through research. Dr. Ibane Abasolo, Scientific Director of NANBIOSIS U20, was at the WORLDSymposia conference last week in Orlando (FL, USA), where the latest advances in preclinical study and clinic of lysosomal storage diseases were explained. There, she presented the results obtained in the Smart4Fabry project coordinated by the CIBER-BBN where nanoliposomes were developed for the treatment of[...] 27 Feb Several CIBER-BBN groups at the University of Barcelona, the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), the Institute of Microelectronics of Barcelona (IMB-CNM-CSIC) and the Institute of Nanoscience and Materials of Aragon (INMA) —a joint institute of the CSIC and the University of Zaragoza (UNIZAR)— have developed a new method for detecting RNA viruses based on the technology of using probes that form triplex structures. This innovative methodology opens up new options to detect viruses such as SARS-CoV-2, the influenza A (H1N1) virus or the respiratory syncytial virus (RSV), a pathogen that affects newborns and requires differential diagnostic care. This[...] 03 Feb CIBER Centro de Investigación Biomédica en Red (Consortium for Biomedical Research Network), one of the ICTS NANBIOSIS nodes to which 18 of its 26 units belong, presents the new institutional video “CIBER is Collaboration” This video puts a face to the scientific activity of CIBER researchers and highlights CIBER capacity for synergy. CIBER researchers speak about the main research lines of its 13 subject areas and highlights the collaboration between its more than 500 groups and more than 6,000 researchers belonging to more than 100 institutions of different natures that make up CIBER: hospitals, research centers, universities, foundations, etc. T[...] 02 Feb Prof Nora Ventosa, Scientific Director of NANBIOSIS U6 “Biomaterial Processing and Nanostructuring Unit” from CIBER-BBN and ICMAB-CSIC) is hosting the Lecture on nano-pharmaceuticals: “Advancing a novel nano-pharmaceutical towards clinical translation” by Elisabet González, from Nanomol-Bio Group of ICMAB-CSIC and CIBER-BBN Monday, 13 February 202312 PM – 15 PMICMAB – Sala d’Actes Carles Miravitlles and ONLINE Registration and futher information Abstract: Nano-pharmaceuticals have the potential to drive the scientific and technological uplift, offering great clinical and socio-economic benefits to the society in general, industry and key stakeholders and patients. However, the translation of nano-pharmaceuticals from lab bench to an advanced stage of[...] 31 Jan Cáceres, 31st January 2023 On the occasion of the training course in Assisted Reproduction that is held today at the CCMIJU facilities, within the Master’s Degree in Advanced Biotechnology (MUBA), organized by the University of Extremadura in collaboration with the CCMIJU, two systems of recent acquisition are handled within the framework of the project “Embryonic Genetics in Assisted Reproduction” (GENERA), co-funded by the European Regional Development Fund (FEDER) within the Spain’s Pluriregional Operational Program for Singular Scientific and Technical Infrastructures (ICTS) 2014-2020 and by the Consejería de Economía, Ciencia y Agenda Digital of the Junta de Extremadura. The above mentioned[...] 27 Jan NANBIOSIS opens in February the 1st competitive open call 2023 for its “Cutting-Edge Biomedical Solutions” and services. NANBIOSIS is a Research Infrastructure for Biomedicine made up of the Platforms of the Center for Centro de Ivesntigación Biomedica en Red (CIBER- in the area of Bioengineering, Biomaterials, and Nanomedicine -CIBER-BBN), the Preclinical Infrastructure and the Development of Minimally Invasive Technologies, of the Jesús Usón Minimally Invasive Surgery Center (CCMIJU) and the Nanoimaging unit of the Biomedical Research Institute of Malaga-Nanomedicine Platform (IBIMA-BIONAND Platform). NANBIOSIS as part of the Spanish Map of ICTS (an acronym for “Scientific and Technical Unique Infrastructures” in[...] 20 Jan Researchers of three groups of CIBER-BBN at CSIC and IBEC, have created a versatile platform based on hierarchically nanostructured RGD peptide using quatsomes, with proved enhanced cell adhesion. These findings, which arose within the framework of the intramural project of CIBER-BBN “Molecular Biointerfaces for cell guidance” (DynaMo4Vasc), open new possibilities for tissue engineering. The participation of two NANBIOSIS units were acknowledged in the publication of the research results: the synthesis of RGD derivatives were performed at NANBIOSIS U3 “Synthesis of peptides unit” of CIBER-BBN at IQAC−CSIC. And the design and characterization of quatsomes were done at U6 of NANBIOSIS “Biomateria[...] 18 Jan The ICTS NANBIOSIS has expanded its capabilities with the installation and commissioning of a new equipment Time-Lapse Incubator in the CCMIJU’s Assisted Reproduction Lab. The acquisition of the Time-Lapse Incubator is part of the project “Embryonic Genetics in Assisted Reproduction” (GENERA), co-funded by the European Regional Development Fund (ERDF) within the framework of Spain’s Plurirregional Operational Program for Singular Scientific and Technical Infrastructures (ICTS) 2014 -2020 and by Consejería de Economía, Ciencia y Agenda Cultural of Junta de Extremadura. The objective of GENERA includes the purchase of lab equipment to expand services in the field of embryonic genetics as w[...] 16 Jan The Horizon Europe project NABIHEAL, coordinated by the Center for Biomedical Research Network (CIBER) at the Institute of Materials Science of Barcelona (ICMAB-CSIC), was launched on 11-12 January 2023 in Barcelona with the first meeting of the international consortium, formed by 14 partners from 7 countries, including research centers, universities, and private companies. This project will apply one the “Cutting Edge Biomedical Solutions” of NANBIOSIS for the preparation of different nanoestructures with antimicrobial properties, required for the development of the final multifunctional wound healing biomaterials. This case will gather the expertise of two NANBIOSIS unit: NANBIOSIS U6 will produce and[...] 24 Nov Amable Bernabé, Tecnical Coordinator of NANBIOSIS U6: Biomaterial Processing and Nanostructuring Unit of CIBER-BBN and ICMAB-CSIC is giving a seminar on Preparation and Characterization of SOFT Materials. The seminar will tame place on Monday, 28 November 2020, at 12 PM at ICMAB in the Carles Miravitlles Seminar Hall, ” I will make a brief explanation about the equipment for the characterisation of particulate materials, type of samples that can be analysed, reports, etc… I will also talk about the equipment for processing materials with C” -explains Amable Bernabé. Amable Bernabé joined the ICMAB-CSIC in 2004 as a research assistant working[...] 23 Nov Researchers of NANBIOSIS U10 “Drug Formulation” – NanoBiocel research group from CIBER-BBN and UPV/EHU receives 3 awards in the category of Best International Articles at the annual Bioaraba Research and Innovation Conference. On 4 November, the Bioaraba Health Research Institute held its XXIII Research and Innovation Conference in Vitoria. This important annual forum held in the city brings together professionals from the health system of Alava, the Rioja region of Alava, the Mental Health Network of Alava, the University of the Basque Country and also professionals from companies in R&D&I in health. On this occasion, the NanoBioCel research group of[...] 15 Nov Today, November 15 is a day of celebration for us, the Day of the Chemistry in Spain! Chemistry is the science that studies matter, how it is composed, its properties and how its structures are transformed and, as matter is everything, including living beings and ourselves, we can say that chemistry is omnipresent and transversal in all areas surrounding us. Chemistry is everywhere, we ourselves are chemistry and our health and our life is chemistry. “Everything around us is chemistry in the environment, foods, what we use and what we touch every day. Our own body is a sophisticated complex[...] 14 Nov Today, the MATERPLAT 2022 General Assembly has taken place at the DFactory Barcelona facilities, in collaboration with Leitat and Airbus. For the first time since the start of the pandemic, the event has been held again 100% face-to-face. The MATERPLAT Technical Secretariat has presented the activities carried out during this period of the platform (2021 and 2022) and the guidelines that MATERPLAT will follow in the next period 2023-2024. In addition, Amaya Igartua (EUMAT) has presented the new 2030 Materials Roadmap, developed throughout 2022, coordinated by EUMAT, EMIRI, SUSCHEM Europe and MANUFUTURE, in which NANBIOSIS will continue to participate throug[...] 11 Nov Researchers of two NANBIOSIS units success in the Third Millennium Awards: the Young Research Talent award to Julia Ramirez (NANBIOSIS U27) and the Research and Future Award to the NFP group (NANBIOSIS U9) Last November 8, four initiatives received the highest award in the eighth edition of the HERALDO contest Third Millennium Awards which represent the recognition of the Aragonese community from the youngest to the most consolidated trajectories in knowledge transfer, innovation, and scientific dissemination. The Paraninfo of the University of Zaragoza hosted this event in which researchers CIBER-BBN – NANBIOSIS were recognised this year: The Films and Nanostructured[...] 10 Nov On the 17th of November, CIBER-BBN group TME lab – NANBIOSIS U13 Tissue & Scaffold Characterization Unit. organises the Conference “Applications of data-driven dynamics to oncology and neuromodulation” by Dr. Michael Ortiz. Michael Ortiz a Frank and Ora Lee Marble Professor Emeritus of Aronautics and Mechanical Engineering at California Institute of Technology. Prior to his arrival at Caltech in 1995, he was Professor of Engineering at Brown University. Since 2020 he also holds positions as Research Chair in the Institute of Applied Mathematics, University of Bonn and as Adjunct Professor and Timoshenko Distinguished Fellow in the departments of Mechanical Engineering[...] 09 Nov The CIBER-BBN and the NANBIOSIS research community has met again, after two virtual editions, to celebrate the Sixteenth Annual Conference of CIBER-BBN. It has been a fantastic a face-to-face reunion during the days 7th-8th November 2022, in A Coruña, Spain. This edition has included sicientific sessions in mental health and in diabetes and metabolic diseases, presentations of internal collaborative projects, two plenary talks given by acknowledged experts in the fields of CAR-T therapies and gene therapies and an invitation to CIBERSAM and CIBERDEM scientific areas, as well as the new “Technological Development Platform of CIBER” to improve translational programs As[...] 27 Oct On October 18 and 19, was held the second course on Social Communication of Science, orgnized by NANBIOSIS U10 Drug Formulation Unit -(NanoBioCell Group of CIBER-BBN and UPV-EHU, this year entitled “Tools for the social communication of science“. The course aimed to provide doctoral students with communication with tools to be employed in their work as scientists when communicating their results or activity to the general public, patients, etc. They first day was mainly dedicated to the use of metaphors in science communication, starting with an interesesting talk by Susana Martinez, director of the Incite Foundation; ateendees had the opportuniy[...] 25 Oct Ramón Martínez Máñez, researcher at the Polytechnic University of Valencia (UPV) and scientific director of the Bioengineering, Biomaterials and Nanomedicine area of the CIBER (CIBER-BBN) and NANBIOSIS U26, has obtained an ERC Advanced Grant –the most prestigious grant from the European Research Council– endowed with 2.5 million euros for the development of the EDISON project (Engineered Particles for Chemical Communication). This project focuses on the field of chemical or molecular communication. Its objective is the study, development and application of nanoparticles that are capable of communicating with each other and whose application would represent a revolution in the field of[...] 24 Oct The MicrofabSpace and Microscopy Characterization Facility of IBEC, U7 unit of Nanbiosis, presented a stand and posters in the 15 edition of the annual IBEC’s Symposium which took place last October 19th in Barcelona. Researechers of this facility showed new microfabrication processes and microscopy tools, to worldwide researchers in the field of bioengineering. The MicroFabSpace and Microscopy Characterization Facility is one of the most experienced services in the IBEC’s Core Facilities. With a cleanroom research space, specialized in the microfabrication and characterization of micro-structured devices focussed on bioengineering and a microscopy space specialized in the characterization of biological samples, it[...] 21 Oct On the 28th of October, we will be receiving the international visit at the Unversity of Zaragoza from Dr. Guillermo Artana from Laboratorio de Fluidodinámica-Facultad de Ingeniería-Universidad de Buenos Aires. The title of the talk will be “Microchannel capillarity pumping design“. The invited lecture is programed within the framework of the European project “Heart On chip based on induced pluripotent Stem cell Technology for personalized Medicine (CISTEM)” and counts with European funding: Horizon 2020 – Research and Innovation Framework Programme / H2020-MSCA-RISE-2017, grant agreement No.778354 in wich the University of Zaragoza participates through CIBER-BBN group TME lab – NANBIOSIS U13[...] 20 Oct ICMAB-CSIC October 19th 2022 Amable Bernabé, from Nanbiosis U6 Biomaterial Processing and Nanostructuring Unit hosted from Monday, 3 October, to Wednesday, 5 October a course on “Characterization techniques for particulate materials”. The course counted with 10 participants from different CSIC centers. The course was an introduction to different techniques to characterize nanoparticles and other particulate matter, including the basic fundamentals of these techniques, sample preparation, practical examples and results interpretation. It is the fifth edition of the course, which started in 2018. Amable Bernabé, technician from the Soft Materials Service, prepares and offers this course to all the CSIC community, so everyone who needs[...] 19 Oct More than 200 people attended the first edition of the TECNIO Conference that took place on October 19th, 2022 in Girona. Outstanding experts from research groups, companies and the Catalan administration discussed the model of technological sovereignty that Catalonia needs to generate high-impact innovation. As far as Nora Ventosa, President of the TECNIO Association and Scientific Director of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit (from CIBER-BBN and IQAC): “Political management is the key to ensure that the path of transference follows a high speed train” Researchers of NANBIOSIS U2 Custom Antibody Service (CAbS) – Nb4D Group from CIBER-BBN and[...] 09 Oct The NanoBioCel group of the CIBER BBN, which also runs NANBIOSIS U10 Drug Formulation unit , organized the Workshop #6 of the Moore4medical European project at the Alava Technology Park on October 4, 5 and 6 The Central Building of the Álava Technology Park hosted the ‘Workshop #6’ of the European project which. 80 people belonging to 68 organizations, including private companies and research groups from universities and research centers from 13 countries of the European Union, participated in a meeting that has the leadership of the Dutch multinational Philips in its divisions of electronics and medical systems and servic[...] 03 Oct CIBER-BBN is looking for a scientific-technical manager within the framework of the European project H2020 SAFENMT SafeNMT aims to create an innovative open access platform for companies and laboratories to develop medical solutions based on nanotechnology. The manager will be coordinating the participation of the CIBER ICTS NANBIOSIS units in it, in collaboration with the CIBER-BBN management team, under the leadership of the scientific director of CIBER-BBN and IP of the project. The position requires good command of English and strong skills in coordinating researchers. Applications must be filed at CIBER’s weportal untill October 14.[...] 28 Sep September 27th 2022 – Nanoligent SL, a Spanish biotech company specialized in the development of cancer treatments based on unique protein conjugates, today announces the completion of a Seed financing round of total € 2.8 M. The final closing of the Seed round consists of € 1 M investment by i&i Biotech Fund I (i&i Bio), an early-stage Life Science fund with teams in Luxemburg and Prague which is backed by the European Investment Fund. i&i Bio joined previous Nanoligent investors, Italian Angels for Growth, the largest network of business angels in Italy, and AVANTECA Partners, a Swiss privately held[...] 23 Sep We are pleased to inform that the new book of Unique Scientific and Technical Infrastructures (ICTS) has been published by the Spanish Ministery of Sciencie and Innovation with the collaborations of the ICTS. You can download it download it here. The Spanish Map of Unique Science and Technology Infrastructures (ICTS, in Spanish) , goups biomedical technologies, cleanrooms, supercomputers, advanced lasers, telescopes, underground laboratories, synchrotrons, particle accelerators, biological reserves, solar, oceanic and hydraulic platforms, oceanographic research ships, and polar bases in Antarctica. A total of 29 ICTS, made up of 64 infraestructures, allow for ambitious research projects that attract first-rate talent and[...] 08 Sep On September 7, the annual meeting of the directors of the 29 Singular Scientific and Technical Infrastructures (ICTS) of Spain took place in Seville. The event was organized in five round tables: Table 1 Development of in-house technology in ICTs and its transferTable 2 ICTS response to crisis situations: the COVID19 pandemic and the La Palma volcano eruptionTable 3 Digital Continuum: data management and processing in ICTSTable 4 Provision of shared ICT Services: connectivity and cybersecurity, implementation of open science in the cloudTable 5 Stimulation of scientific vocations and social interest in ICTSTable 6 National and international cooperation between ICTS[...] 07 Sep The scientific coordinator of NANBIOSIS U25 “RNM: Biomedical Application I”, Ana Paula Candiota, was recently awarded with a mobility fellowship from CIBER-BBN for a scientific exchange visit to Philipps-Universität Marburg, in Marburg, Germany. This scientific stage was motivated for a sustained collaboration between the research groups (GABRMN, in charge of U25 and Neurosurgery Lab group in Marburg), regarding the study of tumour microenvironment (TME) changes in Glioblastoma and possible relationship with the noninvasive MRSI-based biomarkers. Both groups have applied together to different funding calls including ERA-NET Transcan and Pathfinder Open, and Marburg group has hosted a predoctoral stage from a[...] 16 Aug The Academic Ranking of World Universities (ARWU), known as Shanghai Ranking, which was made public on August 15, places the University of Valencia among the elite of the 300 best universities in the world and the second of the Spanish universities. This indicator organizes up to 20,000 university centers worldwide,based on transparent methodology and objective third-party data. ARWU is regarded as one of the three most influential and widely observed university rankings The NANBIOSIS U26 NMR: Biomedical Applications II created by CIBER-BBN is hosted by the University of Valencia is led by Prof. Ramón Martínez Ma´ñez and Prof Salvador Gil Grau[...] 16 Aug The Academic Ranking of World Universities (ARWU), known as Shanghai Ranking, which was made public on August 15, places the Autonomous University of Barcelona among the elite of the 300 best universities in the world. This indicator organizes up to 20,000 university centers worldwide,based on transparent methodology and objective third-party data. ARWU is regarded as one of the three most influential and widely observed university rankings Two of NANBIOSIS Units created by UAB and CIBER-BBN are part of this university: U1 Protein Production Platform (PPP), led by Toni Villaverde, Neus Ferrer and Mercedes Marquez, offer an “tailored” service for the design,[...] 27 Jul During the days 30 of June and 1st of July took place in Barcelona, in the auditorium of the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), the 1st Forum on Nanomedicine gathering scientists from the CSIC net Nanomed Conection and from the CIBER-BBN and its ICTS NANBIOSIS. This forum brought toguether researchers from the most eminent national research centers in nanomedicine, that during the two days meeting presented their works and findings and discussed the impact of nanomedicine in the fields of drug delivery, diagnosis and therapy. The workshop was open by the Director of IQAC-CSIC, Jesús Joglar, the Scientific Coordinator[...] 05 Jul The joint expertise of CIBER-BBN Nanomol Group – NANBIOSIS U6 from at ICMAB-CSIC (José Vidal and Vega Lloveras) and NANBIOSIS U25 at UAB (Ana Paula Candiota), led to a recently published article in the prestigious journal Biomacromolecules Brain tumours such as Glioblastomas are a challenge in the clinics and proper diagnosis and follow-up are crucial for patient outcome. Contrast agents are usually administered to patients for assessing blood brain barrier integrity and quantitation of enhancing areas are part of the clinical criteria for estimating response/relapse. However, most contrast agents currently used in clinics are based in metal elements such as[...] 25 Jun The use of protein nanoparticles as biomaterials have been rising in recent years due to their characteristics: high biocompatibility, structural versatility, biodegradability and plasticity of design. We can later incorporate peptide ligands for specific targeting as fusion proteins and use these nanoparticles for targeted nanomedicine. However, not all proteins can be used as scaffolds for targeted drug delivery, as they need to meet certain criteria. First, it is crucial that the proteins used as a scaffold allow site-specific drug conjugation. The stability and proteolysis resistance of these proteins is also important to remain assembled during the bloodstream circulation. In addition,[...] 10 Jun The Nanomed Conection of the Spanish Research Council (CSIC) and the Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), together with its singular infrastructure NANBIOSIS, have organised a Forum on Nanomedicine Research during the days 30 of June and 1st of July to be held at the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC) in Barcelona. The event will be also transmitted on-line previous registration. This is the first meeting gathering together scientists from CIBER-BBN and its ICTS NANBIOSIS and from the CSIC’ Nanomed Conection with a shared interest in Nanomedicine. This two days meeting will allow researchers[...] 09 Jun ICTS underpins the Spanish reputation for research excellence. In the picture: the new poster of the ICTS map in which NANBIOSIS facilities have been highlighed The term Unique Scientific and Technical Infrastructure (ICTS) refers to facilities, resources, or services for the development of top-quality cutting-edge research, as well as the communication, exchange, and preservation of knowledge, the transfer of technology, and promotion of innovation. They are unique or exceptional in their fields, with a high cost of investment, maintenance, and operation, and are of a strategic importance that justifies their availability to all actors in the field of R&D&I. T[...] 03 Jun NANBIOSIS Unit 17 (Confocal Microscopy) is a CIBER-BBN unit located in the Cell Culture Unit, CAI Medicine and Biology, Faculty of Medicine at the University of Alcala. This unit of the ICTS NANBIOSIS supports researchers interested on their different studies visualizing diverse samples as tissues, cells, bacterial biofilms, etc. This unit owns the tools, the know-how and the expertise to accomplish researchers’ goals either by transmission or reflection fluorescent. We are happy of sharing this video in which researchers of Unit 17 show all the steps required for the visualization of the PV-1 molecule, also known as PLVAP, on t[...] 25 May Elisabet Prats Alfonso, a researcher in the team coordinating NANBIOSIS U8 Micro– Nano Technology Unit explains in a podcast her most recent research based on the functionalization of chemical and biochemical sensor platforms as well as the characterization of materials such as graphene for both neuronal recording and biomarker detection. Her work is part of the Graphene Flagship project in which she collaborates with relevant European groups. Eli Prat as a researcher Ph.D. in Chemistry and also dedicated to dissemination is a great exemple for the NANBIOSIS aim to encourage STEAM scientific vocations especially among girls. In addition, she is[...] 16 May Nora Ventosa, the Scientific Director of NANBIOSIS U6 of Biomaterial Processing and Nanostructuring Unit (and IP of the NANOMOL Group of CIBERBBN at ICMAB-CSIC) has been appointed Research Professor in the last call of the Spanish National Reserach Council (CSIC) This elective process for the selection and appointment of career civil servant, by internal promotion, in the Scale of Research Professors of Public Research Organisms had oppen 6 new positions for Professors under the Materials Science. Nora Ventosa is a Chemical Engineer by the Institut Químic de Sarrià (IQS) and Doctor in Chemistry by the Universitat Ramon Llull. Her researc[...] 10 May Work performed at Unit 25 of Nanbiosis ICTS of “NMR: Biomedical ApplicationsI” is being shown at the Joint annual meeting ISMRM-ESMRMB (May 7-12th) London, with the participation of CIBER-BBN group members Ana Paula Candiota, Silvia Lope-Piedrafita, Miquel Cabañas (abstract 1), Carles Arús, Gulnur Ungan, Margarida Julià-Sapé, Alfredo Vellido and Carles Majós (abstract 2). In the first abstract, entitled “High resolution Multi-voxel spectroscopy using CSI-semi-LASER for mouse brain preclinical studies” we focused into improving quality of MR spectra obtained from mouse brain, a key factor when trying to pursue metabolomic-based biomarkers. The second abstract, entitled “MRSI-detected pattern in glioblastoma patients on[...] 05 May On the 20th of May, we will be receiving an international visit at the Unversity of Zaragoza from Pr. Józef Dulak from Jagiellonian University, Kraków, Poland. The title of the talk will be “Induced pluripotent stem cells in disease modelling and experimental therapies: cardiovascular perspective“. The invited lecture is programed within the framework of the European CISTEM project, in wich the University of Zaragoza participates through CIBER-BBN group TME lab – NANBIOSIS U13 Tissue & Scaffold Characterization Unit. The event will take place at 12:00 in the I3A SEMINAR (2nd floor) of Campus Rio Ebro, of University of Zaragoza Induced pluripotent[...] 03 May Dr. Ramon Eritja, Scientific Director of NANBIOSIS unit 29 of Oligonucleotide Synthesis Platform (OSP) and Dr. Santiago Grijalvo researcher at NANBIOSIS unit 12 of Nanostructured liquid characterization, from CIBER-BBN and IQAC-CSIC, together with Dr. Andreia F. Jorge, from Coimbra Chemistry Centre (CQC), acting as guest editors of journal Pharmaceutics, of MDPI Publisher, welcome authors to submit their articles on special issues on Recent Trends in Oligonucleotide Based Therapies. In the past few decades, significant efforts have been made towards the clinical application of oligonucleotides. However, the potential of the therapeutic applications of RNA-based strategies have recently been spotlighted after the first approval of mRNA vaccines in response to COVID-19[...] 02 May During the last 27-29 April, the 3rd International Conference on Nanomaterials Applied to Life Sciences 2022 (NALS 2022) has taken place in the Excellence Campus of Universidad de Cantabria in Santander (Spain), organized by the University of Cantabria and Institute Valdecilla-IDIVAL. NALS 2022 has been a multidisciplinary conference series sharing new results and ideas in the fields of biosensors, lab on a chip, drug delivery nanopharmacy. nanobiotechnology, intelligent nanomaterials, magnetic materials, nanotoxicity, antimicrobials, novel applications of 3d bioprinting and nanoimaging. NANBIOSIS has been represented at this edition by members of several of its units, among them we must highlight the set of four ora[...] 29 Apr Cystic fibrosis is an inherited genetic disease that mainly affects the lungs and the digestive system On April 6, the first meeting was held, on the one hand, with people with Cystic Fibrosis and the Euskadi Cystic Fibrosis Association (Arnasa) and, on the other, with the NanoBioCel research group of the CIBER-BBN and the University of Basque Country, which is also part of the ICTS Nanbiosis through the Drug Formulation Unit U10. The cooperative relationship between the NanoBioCel research group and Arnasa began approximately 5 years ago with the contributions made by the association to the NanBioCel group for researc[...] 28 Apr From 11 to 15 of July 2022 will take place the Nanomed-CSIC Summer School, organized by the Menéndez Pelayo International University (UIMP), with the sponsorship and collaboration of the CSIC. The Nanomed-CSIC Summer School brings together scientific experts from all over Spain in different fields of nanomedicine and is aimed at all research staff and students, at any stage of basic or advanced scientific training. There are scholarships from the Menéndez Pelayo International University (UIMP) which application period ends on May 3, 2022. For further informations and appalications follow this link The course reviews the latest international advances in areas[...] 27 Apr Dr. Anna Aviñó, Scientific Coordianator of NANBIOSIS unit 29 of Oligonucleotide Synthesis Platform (OSP) and Dr. Carme Fàbrega from the Nucleic Acid Chemistry group from CIBER-BBN and IQAC_CSIC, together with Dr. Claudia Riccardi from the University of Naples Federico II, Dr. Stefania Mazzini from University of Milan, and Dr. Raimundo Gargallo from the University of Barcelona, acting as guest editors of the journal Frontiers in Chemistry, welcome authors to submit their articles on special issues on Nucleic Acid-Based Aptamers in Therapeutics and Diagnostics. Nucleic acid‐based aptamers are short DNA or RNA sequences able to adopt specific three‐dimensional architectures. The high affinity and selectivity shown for a selected target, as well as t[...] 22 Apr The Minister of Science and Innovation, Diana Morant, chaired the XI meeting of the Council for Scientific, Technological and Innovation Policy, in which the update of the Map of Singular Scientific and Technical Infrastructures, the ICTS Map for 2021-2024, was approved. The ICTS are facilities dedicated to cutting-edge research of the highest quality, as well as to the transmission, exchange and preservation of knowledge, technology transfer and the promotion of innovation. The map has 29 ICTS distributed among all the territories, includes NANBIOSIS, the Infraestructure for Production and Characterization of Nanomaterials, Biomaterials and Systems in Nanomedicine with its 26 units.[...] 21 Apr The discovery of the mRNA vaccines for the treatment of coronavirus, as well as new medicines for the treatment of genetic diseases, has been important in the quest of solutions for undrugable diseases in an unexpected short-time. Thus, the chemical modifications of nucleic acids with diagnostic and therapeutic purposes is now a reality, a revolution that promises to give hopes on unsolved medical problems or optimize previous approaches, largely due to the research push for the development of mRNA vaccines against SARS-CoV-2 infection. Now, the prestigious “The Chemical Record” journal has invited the Nucleic Acids Chemistry group, of IQAC-CSIC and[...] 18 Apr ICTS-NANBIOSIS. UNIT 17 CONFOCAL MICROSCOPY SERVICE. (CIBER-BNN. UNIVERSITY OF ALCALÁ) The UAH research groupTranslational research of chronic diseases associated with aging and kidney disease has recently published an article in which unit NANBIOSIS unit 17 and Leica SP5 confocal microscope has had a great contribution Located in the Support Center for Research in Medicine and Biology, Faculty of Medicine and Healthe Sciences, University of Alcalá (UAH). The Unit is equipped with a Leica TCS-SP5 confocal microscope. The confocal module is equipped with three spectral detection channels, AOBS (Acousto-optical beam splitter) and a resonant scanner system that allows analysis at hig[...] 08 Apr The aim of the quality certification obtained is to ensure the quality of the service provided and to continue with its improvement and extension to future services. The Scientific and Technical Service for the characterization of nano and biomaterials, the Soft Lab, run by the Nanomol Research Unit of the Institute of Materials Science of Barcelona (ICMAB, CSIC), and which is part of Unit 6 of the ICTS Nanbiosis, and CIBER-BBN, aims to offer characterization services of micro- and nanostructured soft molecular materials to the entire scientific community that requires them. To this end, the Soft technical service has several laboratories at[...] 07 Apr In the Picture: Gemma Gabriel and Rosa Villa World Health Day is celebrated every year on 7 April (on the aniversary of the World Health Organization constitution) to raise awareness about the ongoing health issues that concern people across the world. This year, Xarctec Salud has called the attention on patients with brain diseases and spinal cord injuries and has highlighted the GAB Lab. Biomedical Applications Group of the IMB-CNM-CSIC and CIBER-BBN, the group, led by Rosa Villa, coordinates unit 8 ICTS NANBIOSIS of Micro-nano Technology Unit. https://youtu.be/wiA5oFc6Q48 The Xartec Salut is a network, led by CREB UPC, made up of 47[...] 06 Apr On April 1st PhD candidate Patricia Cámara Sánchez defended her doctoral thesis entitled “Targeting of the breast cancer stem cells to improve the treatment of triple negative breast cancer“, where ICTS-Nanbiosis Unit 20 participated in the in vivo assays. The thesis was supervised by Dr. Ibane Abasolo (scientific director of Unit 20 from CIBER-BBN and VHIR). Nanbiosis was also present within the jury, with Dr. Ana Paula Candiota (scientific coordinator of Unit 25 from CIBER-BBN and UAB) acting as secretary. Patricia Cámara graduated as biochemist, did the master’s degree in Translational Biomedical Research from VHIR-UAB. Shortly after, started the PhD, which was aimed[...] 05 Apr Cystic Fibrosis is a genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. It is a genetic, degenerative and chronic disease, with a population incidence is 1 in 5,000, so it is considered among the so called “Rare Diseases” The most common symptoms are continuous colds, repeated infections, decreased lung capacity, impossibility of fat absorption and malnutrition As there is no cure for the disease, daily treatment is the only option to have an acceptable quality of life The NanoBioCell Research Group, which coordinates unit 10 of NANBIOSIS of the CIBER-BBN and the UPV/EHU, has a wide experience in comprehensive researc[...] 29 Mar CIBER, March 28 2022 Researchers from the Polytechnic University of Valencia (UPV) and the CIBER-BBN has demonstrated, for the first time, the potential of using “translator” nanoparticles to facilitate communication between different types of cells or microorganisms. His study could have application in multiple fields, especially in the medical field for the prevention and treatment of cancer. “We have shown that it is possible to communicate microorganisms from different kingdoms using nanoparticles as translators. The nanoparticles process a message produced by the first type of cells (bacteria) and transform it into an understandable message for the second type of cells[...] 28 Mar NANBIOSIS, U20. In Vivo Experimental Platform, led by Dr. Ibane Ibasolo, has been updated and improved as a result of its participation in the project FICTS1420-20, selected by the MICINN for co-financing by the FEDER Program in ICTS 2014-2020 (Equipment for setting standardized immunotoxicology assays for the U20 -NANBIOSIS I17 Action of the Investment Plan-)[...] 22 Mar In the picture: microencapsulated cardiospheres 10X Captured Brightfield with DM_RGB_Brightfield with DM The European project POSITION-II has been selected for publication in the ‘Results in Brief’ section of the Community Research and Development Information Service (CORDIS) website. CORDIS is the European Commission’s primary source of results from the projects funded by the EU’s framework programmes for research and innovation (FP1 to Horizon 2020). The resulting short article has now been published on the CORDIS website in six languages. The European project POSITION II “A pilot line for the next generation of smart catheters and implants” is an alliance of European[...] 20 Mar Pancreatic ductal adenocarcinoma is a highly devastating orphan disease with poor prognosis even when diagnosed early (The survival rate after 5 years (< 5%) has not changed over the last 30 years, despite tremendous research efforts) The european project NoCanTher, in wich participates NANBIOSIS U20 of (VHIR and CIBER-BBN) is a nanotechnology-based approach aimed to scale-up under GMP conditions and evaluate a nanoformulation for a combined therapy with chemotherapy against this pancreatic cancer. The international clinical study, carried out in the framework of the project is now incorporating the first pacient in Spain with this type of nanotherapy. The clinica[...] 17 Mar A CIBER-BBN team at the University of Zaragoza has developed intelligent shuttles (cell vesicles -exosomes-) to transfer nanoparticles to the interior of tumor cells and destroy them by means of heat and without drugs, following the “Trojan horse” strategy. “NANBIOSIS U9, “Synthesis of Nanoparticles Unit has developed the procedure to be able to internalize gold nanoparticles, with surface plasmon in the NIR electromagnetic range, inside extracellular vesicles derived from stem cells. The synthesis of the gold nanoparticles has been produced according to the synthesis procedures of UNIT 9 of the ICTS NANBIOSIS based on the galvanic substitution reaction in t[...] 08 Mar Start-ups / SMEs! Are you working on innovative medical products using nanotechnology? This is your call for development and marketing solutions! Last week took place the SAFE-N-MEDTECH Open Call on line info session with the idea to present the open call with a bit more detail. A few presentations and specially a time for questions and answers were organized by Anaïs Le Corber, Network Manager of CEBERG, the council of European Bioregions, partner of the project. The webinar was recorded and it is available here: First of all, Angel del Pozo, Coordinator of the SAFE-N-MEDTECH, gave an insight of t[...] 02 Mar Esther Pueyo, member of the BSICoS group, which coordinates NANBIOSIS U27 “High Performance Computing” from CIBER-BBN and I3A-UZ, participes with Lina Badimon, professor at the CSIC and group leader at the CIBERCV in the first of a series of videos where two women scientists share their experiences, prepared by the Scientific Culture and Innovation Unit (UCC+i) of the CIBER Both researchers work in the field of Cardiology and share their passion for science and their vocation to help patients. In this video they talk in depth about their career, their difficulties, their achievements, and what their vision is about t[...] 28 Feb WHY DO CELEBRATE TODAY THE INTERNATIONAL #RareDiseaseDay? 29 of February is a ‘rare’ date and February, a month with a ‘rare’ number of days, has become a month to raise awareness about rare diseases and their impact on patients’ lives. Since 2008 thousands of events happen every year all around the world and around the last day of February with the aim of improving equity and reducing stigmatization for people who live with more than 6,000 rare diseases. WHAT ARE RARE DISEASES Rare diseases are pathologies or disorders that affect a small part of the population (less than 5 per 10,000 inhabitants) and[...] 21 Feb An Open Call within H2020 project SAFE-N-MEDTECH OITB -Safety testing in the life cycle of nanotechnology-enabled medical technologies for health– has been launched with the objective of providing services and support to companies and other organizations with the aim of accelerating the development and commercialization of innovative MedTech solutions based on nano-enabled technology. SAFE-N-MEDTECH in which CIBER-BBN is a partner througth its ICTS NANBIOSIS, gathers expertise from 28 partners around the world focused in enabling the safe translation of nano-enabled medical technologies from Proof of Concept to markets and clinical practice funded project SAFE-N-MEDTECH with its key expertise and extensive knowledge in[...] 17 Feb Obesity is caused by the enlargement of the white adipose tissue (WAT) depots, characterized by the hypertrophic enlargement of malfunctioning adipocytes within WAT, which increases the storage of triglycerides (TG) in the lipid droplets (LD). Adipogenesis pathways as well as the expression and activity of some extracellular matrix receptors integrins are upregulated. Integrinβ1 (INTB1) is the main isoform involved in WAT remodeling during obesity and insulin resistance-related diseases. We recently described Integrin Linked Kinase (ILK), a scafold protein recruited by INTB1, as an important mediator of WAT remodeling and insulin resistance. As the few approved drugs to fight obesity hav[...] 15 Feb The leader of the NanoBioCell Group form CIBER-BBN and UPV/EHU, Jose Luis Pedraz, and the reaearches Laura Saenz del Burgo and Markel Lafuente have received the 2021 Award from the Academy of Pharmacy of Castilla y León, on February 4, at the city of Salamanca, for the work entitled: “Design and Characterization of a biotin formulated with nanocellulose, alginate and Gags for use in 3D bioprinting and application in cartilage regeneration“, the content of this research work has been published in the Journal Macromolecular Science under the title: “Chondroitin and Dermatan Sulfate Bioinks for 3D Bioprinting and Cartilage Regeneration” T[...] 09 Feb The International Day of Women and Girls in Science on February 11 honor women’s significant achievements in science and place a much-needed focus on girls entering Science, Technology, Engineering, and Mathematics (STEM) careers. We want to take this day to congratulate all the women scientists, especially our scientists at NANBIOSIS ICTS. Some of them take an active role in the dissemination of research results and reseach contribution to the society, as Dr. Ibane Abasolo who last week participated in different events to explain her team work in the figth against breast cancer. Ibane Abasolo is the Scientific Coordinator of NANBIOSIS U20 and also[...] 08 Feb The International Day of Women and Girls in Science on February 11 honor women’s significant achievements in science and place a much-needed focus on girls entering Science, Technology, Engineering, and Mathematics (STEM) careers. We want to take this day to congratulate all the women scientists, especially to our scientists at NANBIOSIS ICTS. In this occasion we want to put the spotlight on Raquel Bailon, researcher of Bsicos Group coordinating NANBIOSIS Unit 27 of High-Performance Computing form CIBER-BBN and University of Zaragoza-I3A, who last month has been highlighted by Inside Signal Processing Newsletter. In the interview Dr. Raquel Bailon talks about her motivations[...] 07 Feb The International Day of Women and Girls in Science on February 11 honor women’s significant achievements in science and place a much-needed focus on girls entering Science, Technology, Engineering, and Mathematics (STEM) careers. We want to take this day to congratulate all the women scientists, especially to our scientists at NANBIOSIS ICTS, some of whom take an active role in the organization of events to celebrate this day, as Estefanía Peña in the initiative “Women Scientists in your neighborhood” form the University of Zaragoza. Estefanía Peña is the Cientific Coordinator of Unit 13 of Tissue & Scaffold Characterization from t[...] 04 Feb Nanovesicles, known as quatsomes, have been successfully engineered to encapsulate and deliver microRNAs for the treatment of tumors.These nanovesicles are produced by a simple GMP compliant process, an unavoidable requirement for the clinical use of new drug candidates.The study, published in Small, has been highlighted in the Women in Materials Science issue of Advanced Materials. “The beauty of these quatsomes nanovesicles is that they can be easily engineered for the delivery of a variety of nucleic acids. Importantly, they are stable at room temperature, which avoids problems associated to cold chain requirements”, says Nora Ventosa, Scientific Director of NANBIOSIS U6.[...] 03 Feb Barcelona, Spain – Milan, Italy, February 3rd, 2022 – Nanoligent SL, a biotech company specialized in the development of nanotechnology-based cancer treatments, today announces the completion of the first closing of a Seed financing round of €1M. The round has been led by members of Italian Angels for Growth, the largest network of business angels in Italy, through the investment vehicle Nanolinvest, and AVANTECA Partners, a Swiss privately held asset management firm, both specialized in supporting innovative early-stage life-science companies primarily in Europe. An equity campaign, is still ongoing on Doorway, an online investment platform, thus promising to provide additional funding[...] 03 Feb Twenty years ago, the 4 February was declared World Cancer Day with the global challenge of cancer would not be forgotten. Since then, huge progress has been made to understand, prevent, diagnose, and treat cancer. NANBIOSIS as an ICTS (Singular Scientific and Technical infrastructures) for biomedical research plays a very important role in the fight against cancer. Dr. Miriam Royo, who leads NANBIOSIS unit 3 of Synthesis of Peptide, explains one of the projects in which the ICTS is involved in relation with cancer therapy. The improvement of solubility and stability of clinically approved chemotherapeutic drugs still represent a big[...] 24 Jan Nora Ventosa and Mariana Köber, from NANBIOSIS Unit 6 of CIBER-BBN and ICMAB-CSIC, and Judit Morlà-Folch, from the BioMedical Engineering and Imaging Institute at the Icahn School of Medicine at Mount Sinai, New York, are editors of the Special Issue of MDPI Pharmaceutics. The Special Issue on “Fluorescent Organic Nanoparticles for Bioimaging and Theragnostics“ belongs to the “Nanomedicine and Nanotechnology” section and has a deadline for manuscript submissions on 25 July 2022. The guest editors explain the main topic of this Special Edition: “Fluorescence-based techniques play an essential role in the study of biological events in tissues and animals due to their specificity and noninvasive nature. However,[...] 13 Jan Edorta Santos Vizcaíno has been awarded as Best Emerging Researcher in the biomedical area by the Bioaraba Health Research Institute in the XXII edition of the Research and Innovation Conference. This award aims to recognize the work of researchers under the age of 40 who carry out their research activity in any public center of the Araba Health Network (OSI ARABA UNIVERSITY HOSPITAL / BIOARABA). The main award´’s criteria are the quality of the research carried out, active participation in public and private research projects, fidelity to the line of biomedical research and the usefulness and interest of the researc[...] 12 Jan A new work by researchers from the CIBER-BBN at the Barcelona Institute of Materials Science ICMAB-CSIC, together with a team from the University of Rome Tor Vergata, presents new nanovesicles capable of crossing biological barriers such as cell membranes, maintaining their sensory capacity, making them attractive probes for intracellular biomarker detection. “The development of probes capable of detecting the biological environment and signaling the presence of a specific target molecule is a challenge with relevance in a variety of biomedical applications, from drug administration to diagnostic tools” says Mariana Köber, one of those responsible of the investigation together with Nora[...] 11 Jan Researchers of NANBIOSIS Units 1 and 18, from CIBER-BBN at the Institut de Biotecnologia i de Biomedicina (IBB-UAB) and the Institut de Recerca Sant Pau (IIB-Sant Pau) presents the finding of a significant antimicrobial activity in the targeting peptide T22, which is used for antitumor therapy directed against CXCR4 + stem cells, with clinical interest in more than 20 types of human cancer, including colorectal cancer. The study describes how said activity has a significant effect on several bacterial species of clinical importance: “we have detected antimicrobial activity associated with T22 and inhibition of biofilm formation on Escherichia coli, Staphylococcus[...] 07 Jan A study published in Nature Nanotechnology shows that flexible brain probes made of graphene micro-transistors can be used to record pathological brain signals associated with epilepsy with excellent fidelity and high spatial resolution. This research was led by the Institute of Microelectronics of Barcelona (IMB-CNM-CSIC), the Catalan Institute of Nanoscience and Nanotechnology (ICN2) and the University College London Queen Square Institute of Neurology (UK). The ability to record and map the full range of brain signals using electrophysiological probes will greatly advance our understanding of brain diseases and aid the clinical management of patients with diverse neurological disorders. However, current technologies[...] 05 Jan Nora Ventosa, Scientific Director of NANBIOSIS Unit 6, is the president of the new Association of TECNIO. the association to promote technology transfer to Catalonia that was established on November 8, 2021 with the collaboration of all Catalan universities, the I-CERCA foundation and the CSIC. This association promotes technology transfer to companies through the connection of research groups with TECNIO, as it is the case of the DBA. An initiative that includes the support of the Generalitat per mitjà d’ACCIÓ, the agency for the competitiveness of the company of the Departament d’Empresa i Treball. The new Associació TECNIO is mad[...] 28 Dec Pseudomonas aeruginosa is a common multidrug-resistant pathogen that causes acute and chronic infections. However, P. aeruginosa, as many other bacterial species, has developed resistance to antibiotics being difficult to treat. For this reason diagnostic methods allowing detection at early stages of the infection are required and, therefore, efficient biomarkers of infection are very helpful. These fast diagnosis will help on the subsequent therapeutic treatment. The Nb4D group of CIBER-BBN and IQAC-CSIC (led by M.-Pilar Marco) has recently conducted a research to develop a highly sensitive, specific and reliable immunochemical assay to detect pyocyanin (PYO), one of the most important virulence factors[...] 24 Dec Nucleic Acid Chemistry is an interdisciplinary discipline that combines organic chemistry, biochemistry, pharmacology, materials chemistry and biophysics. It started soon after the Watson–Crick model of DNA with the synthesis of the first dinucleotide, published in 1955. However, in the last decade, this field has blossomed, with the demonstration that Nucleic Acid Chemistry can provide innovative solutions to health problems such as vaccination, pathogen detection, and the treatment of metabolic or genetic diseases as well as providing important tools for the interrogation of cellular mechanisms. Profesor Ramon Eritja, Scientific director of the Oligonucleotides Synthesis Platform U29 from ICTS NANBIOSIS will chair[...] 23 Dec A study published in “Nature Nanotechnology” shows that flexible brain probes made of graphene micro-transistors can be used to record pathological brain signals associated with epilepsy with excellent fidelity and high spatial resolution. This research was led by the Catalan Institute of Nanoscience and Nanotechnology (ICN2), the Institute of Microelectronics of Barcelona (IMB-CNM-CSIC) and the University College London Queen Square Institute of Neurology (UK). Barcelona, Wednesday 22 December 2021. The ability to record and map the full range of brain signals using electrophysiological probes will greatly advance our understanding of brain diseases and aid the clinical management of patients wit[...] 22 Dec The final decision on the call for funding of Singular Scientific and Technical Infrastructures (ICTS) within the framework of the Recovery, Transformation and Resilience Plan in 2021 for has been published. These grants are intended to facilitate the execution of the Strategic Plans of the ICTSs included in the current National Map of ICTSs, through the execution of the investments provided for in their investment plans and declared of high priority by the Advisory Committee for Singular Infrastructures (CAIS). Two applications were submitted to this call by NANBIOSIS: one by the CIBER node named “Towards a new generation of Infrastructur[...] 21 Dec The medicine of the future is an increasingly tackled topic. In the context of global concern for the sustainability of the health system (chronic diseases, new disorders, aging population and financing problems), nanomedicine could promote more affordable and personalized health care and improve the quality of life of the patients. Between innovative techniques already implemented and concepts that evoke science fiction (nanobots, fluorescent particles working as spies, tiny Trojan horses introduced into our body …), nanomedicine generates great expectations. Nanomedicine, what is it exactly? Nanomedicine is the application of nanotechnology to medicine, that is, the use of nanotechnologic systems for[...] 03 Dec National and international leading researchers met online last November 15 and 16 at the XV CIBER-BBN Annual Congress to discuss the latest advances in bioengineering, biomaterials and nanomedicine research, and promote further collaborations in the field. This year’s CIBER-BBN Annual Conference included three plenary lectures given by internationally recognized experts in the fields of SARS-CoV-2 infection and vaccination, biomedical signal processing for sleep disorders, and regenerative medicine and biosensors. In addition to a selection of internal collaborations, valorization projects and collaboration projects with the CIBER of Oncology, the three programs of the Precision Medicine Infrastructure (IMPaCT) were presented. NANBIOSIS ICTS[...] 01 Dec Scientists of CIBER-BBN and NANBIOSIS ICTS have participated in the 4th Conference “Anticipating the Medicine of the Future”, which took place on November 30th, organized by the Roche Institute Foundation. The topics for this ediction had been identified by the Observatory of Trends in the Medicine of the Future: Pharmacogenomics, Nanomedicine and Epigenomic The event counted with three roundtables for discussion in relation to the three topics. The second one, on Nanomedicine, was moderated by Joaquín Arenas, Director of the Research Institute of the 12 de Octubre University Hospital. Ramón Martínez Máñez, Professor of Inorganic Chemistry at the Interuniversity Researc[...] 29 Nov Sara Montero, researcher of the “Drug Delivery and Targeting” of CIBER-BBN and VHIR, presented her thesis work on November 22 “Nanotecnnology mediated extrategies targeting cancer stem cells for advanced cancer tratment”, directed by Dr. Simó Schwrtz and Dr Diana Rafael. In vivo experiments where carried out through the Unit 20 of the ICTS NANBIOSIS. The work presented by Sara Montero shows two different types of therapeutic strategies for the treatment of advanced breast and colon cancer. Both strategies focus on blocking proteins essential for the survival and proliferation of cancer stem cells (CMC), known to be the main responsible for current therapeutic failures, tumor[...] 28 Nov Patricia González, researcher of the “Drug Delivery and Targeting” of CIBER-BBN and VHIR, presented her thesis work on November 19 where she lays the foundations to understand the role of different subpopulations of extracellular vesicles (VEs) secreted by tumor models in the regulation of tumor plasticity, as well as its effect on the tumor microenvironment and disease progression. In the project, it has been described for the first time how the VEs secreted by the cancer stem cell subpopulation are responsible for activating fibroblasts in the tumor microenvironment and promoting angiogenesis, thus facilitating disease progression. Furthermore, it has been possib[...] 26 Nov The Unit 10 of Drug Formulation of the ICTS NANBIOSIS coordinated by the CIBER-BBN NanoBioCel group directed by Jose Luis Pedraz, which belongs to the University of the Basque Country, has been present at the signing of the agreement that gives support by the Provincial Council of Alava within the framework of the Advance Pharma Development project, together with the research and technological development center TECNALIA. With this agreement, the NanoBioCel research group will receive in the next two years (2021-2023) a contribution of 650,000 €, which will allow the hiring of research personnel and the purchase of specific equipment[...] 22 Nov Twenty five Spanish researchers linked to the Higher Center for Scientific Research, CSIC, who are working more directly on the project ‘Point-of-care tests for the rapid detection of SARS-CoV-2’ – Studies for the development of technologies effective diagnosis and early detection of SARS-CoV-2- have met since last Wednesday and until this Friday at the Benasque Science Center ‘Pedro Pascual’ to analyze the state or of the different programs and lines of research on the covid-19. After months of intense work, among the most outstanding achievements in relation to the detection of the genetic material of the virus, is the development[...] 15 Nov The CIBER for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) will hold its XV Annual Congress, which will be held online for another year, on November 15 and 16. The conference will begin with a welcome that will be given by Cristóbal Belda, director of the ISCIII, and the scientific director of CIBER-BBN Ramón Martínez Máñez, and will aim to share advances in research in bioengineering, biomaterials and nanomedicine, in addition to advancing synergies with other disciplines and institutions. This year’s edition will include three plenary talks given by internationally recognized experts in the fields of SARS-CoV-2 infection and vaccination, biomedical signa[...] 04 Nov Semiconductors are materials used in a wide ranfe of applications since they are capable of capturing light and allowing us to take advantage of it. In addition, if we reduce its size to the nanometric scale we can activate additional very interesting properties On October 16, “Technoscience and Energy” took place in Inseec, Lyon (France), a science-industry transfer event between French and Spanish companies and researchers from the energy sector in France. Among the invited speakers was María Bernechea Navarro, ARAID Investigator, at the Institute of Nanoscience and Materials of Aragon at University of Zaragoza-INMA. In her talk, entitled “COLLOIDAL[...] 02 Nov Next November 8, the researcher of NANBIOSIS U2 Custom Antibody Service (CAbS) J.-Pablo Salvador will host the Seminar “Nanobodies for biosensing” in the framework of European Biosensor Symposium digital seminar series which are schedulled on the third Tuesday of every month. Nanobodies® (Nbs) are the recombinant binding domain from the heavy chain antibodies tipically produced from camèlids. Besides their great potential as molecules in drug development, Nanobodies possess excellent functional properties that aid in their development for diagnostic tools. In this seminar, Dr. Salvador will explain the the outstanding properties of Nanobodies. Three graduate student speaker and up to five graduat[...] 29 Oct Dr. Ramon Mangues, head of the Oncogenesis and Antitumor Group and Scientific Director of NANBIOSIS U18 Nanotoxicology Unit of CIBER-BBN at the Sant Pau Research Institute, has been recently elected as a new member of the Royal Academy of Pharmacy of Catalonia. The celebration will take place on November 8 at 7 pm, at the headquarters of the RAFC, (Royal Academy of Pharmacy of Catalonia) which was the headquarters of the old Hospital de la Santa Cruz since the 15th century, located at Calle del Hospital, 56, in Barcelona. During the event, Dr. Mangues will read his admission speech “Selectiv[...] 25 Oct NANBIOSIS U6, Biomaterial Processing and Nanostructuring Unit from CIBER-BBN and ICMAB-CSIC, has received today the visit of students of the 4th year degree in Nanoscience and Nanotechnology of the Auonomous University of Barcelona. During this visit, the students had the opportunity to get known of the facilities of Unit 6 of NANBIOSIS ICTS and the to work in a research laboratory. José Amable Bernabé has, Technical Coordinator of the unit, has shown the students the equipment for processing materials with compressed fluids and also some equipment for the characterization of particulate materials. In the Degree in Nanoscience and Nanotechnology at[...] 21 Oct CIBER | October 14, 2021 CIBER, the main partner of NANBIOSIS obtained, last month, the ISO 9001: 2015 accreditation, issued by the ENAC (National Accreditation Entity) through TÜV Rheinland Ibérica Inspection, Certification and Testing SA, by which the quality in the CIBER management system is certified. The scope of the quality management system defined in the certificate covers: “Staff and training management services, administrative accounting and communication management services for the Center for Biomedical Research on the Net”. CIBER keeps updated the Quality Management System (QMS) designed to continuously improve the effectiveness and efficiency of performance, through the consideration of t[...] 18 Oct NANBIOSIS U12 “Nanostructured liquid characterization unit” of IQAC-CSIC and CIBER-BBN, led by Dr. Carlos Rodriguez Abreu and D. Jordi Esquena, has implemented a Quality Management System for the scope of Technological service for characterization of colloidal dispersions, which fulfills the requirements of the standard ISO 9001:2015. An IQNet recognized certificate has been issued by AENOR last week. This certification will expand and consolidate the service that Unit 12 of NANBIOSIS is giving to companies and public sector researchers and facilitate their integration in cooperative international projects. The ISO 9001 Standard is the most widespread Quality Management tool worldwide, with over[...] 15 Oct Zaragoza, October 14th, 2021 Bsicos.i3a.es Pablo Laguna, Scientific Director of NANBIOSIS U27 High Performance Computing and researcher of BSICoS Group of I3A-UNIZAR and CIBER-BBN gave a talk about Physiologically driven biomedical signal processing at the Faculty of Physics at the Autonomous University of San Luis Potosí (UASLP) in Mexico. He explaned how biomedical signals convey information about biological systems and can emanate from sources of as varied origins as electrical, mechanical or chemical. In particular, biomedical signals can provide relevant information on the function of the human body. This information, however, may not be apparent in the signal due to measurement noise,[...] 14 Oct Cáceres, October 14th, 2021 POSITION II has received funding within the Electronic Components and Systems for European Leadership Joint Undertaking (ECSEL JU) in collaboration with the European Union’s H2020 Framework Programme (H2020/2014-2020) and National Authorities, under grant agreement Ecsel-783132-Position-II-2017-IA. It promotes innovation in smart medical instruments and focuses in the next generation of smart catheters and implants by the introduction of open technology platforms for: miniaturization, in-tip AD conversion, wireless communication, MEMS transducer technology and encapsulation. These platforms are open to multiple users and for multiple applications. POSITION II will enable the further development of the European R&D and manufacturing[...] 08 Oct C2C12 myoblast cells differentiating into myotubes and adopting unusual shapes have been obtained and captured by resarchers of UAH and NANBIOSIS Unit 17 Confocal Microscopy Service (of CIBER-BBN and UAH) and and chosen photo of the month by the Spanish Society of Biochemistry and Molecular Biology (SEBBM) The picture illustrates the month of October on the calendar that the SEBBM publishes and distributes annually among all partners, and is part of the gallery of images that illustrate the activities of the SEBBM. Likewise, the photography will participate in the “Best Scientific Image of the Year” contest. The winning image is[...] 06 Oct Cáceres, 6/10/2021 Today the provider of a Piezoelectric-assisted micromanipulator installs this device in the CCMIJU’s Assisted Reproduction Lab and provides of specific training for its use. The acquisition of the micromanipulator is part of the project “Embryonic Genetics in Assisted Reproduction” (GENERA), co-funded by the European Regional Development Fund (ERDF) within the framework of Spain’s Plurirregional Operational Program for Singular Scientific and Technical Infrastructures (ICTS) 2014 -2020 and by Consejería de Economía, Ciencia y Agenda Cultural of Junta de Extremadura. The objective of GENERA includes the purchase of three devices to expand services in the field of embryonic genetics as[...] 04 Oct Researchers of NANBIOSIS units U14 Cell Therapy unit, U21 Experimental operating rooms and U24Medical Imaging at JUMISC are coauthors of an article recently published by the journal Cells “Intracoronary Delivery of Porcine Cardiac Progenitor Cells Overexpressing IGF-1 and HGF in a Pig Model of Sub-Acute Myocardial Infarction“· Large animal studies have been carried out by the ICTS ‘NANBIOSIS’, specifically Units 14, 21, 22, and 24 of the JUMISC Human cardiac progenitor cells (hCPC) are considered a good candidate in cell therapy for ischemic heart disease, demonstrating capacity to improve functional recovery after myocardial infarction (MI), both in small and larg[...] 30 Sep We want to invite you to a practical and short course of Introduction to Scientific Communication organized by CIBER-BBN and NanoBioCellGroup – NANBIOSIS U10 Drug Formulation Unit. The course will take place on the 5th (two hours from 9:00 am to 11:00 am) 6 and October 7 (4 hours from 9:00 a.m. to 1:00 p.m.) .- The covid-19 pandemic has revealed the immense need to bring the world of science closer to citizens, so we are going to work on this soft skill through this course. We have invited Inés Ortega, scientific communicator of the CIBER BBN, who will talk[...] 29 Sep CIBER-BBN, partner of NANBIOSIS, has started a new partnership with Ximbio, part of Cancer Research UK, the largest independent funder of cancer research in the world, to facilitate the commercialisation of life science research tools. This new partnership with Ximbio will help CIBER-BBN groups to develop as bussiness the research tools from their labs and units of NANBIOSIS into commercial products, making them easily available for industry and other academics (including those not under patent protection), from sourcing and production, to sales, licensing and responding to enquiries about your reagents. On October 1st, 2021 – 11:00 – 12:30 CEST , with take place the on[...] 24 Sep Cristina Pérez, has been the winner of the Young Researcher Award (YIA) at the STAFF congress held in Sirolo (Italy), from Septembre 1 to 4, for her work entitled “Characterization of impaired ventricular repolarization by quantification of QT delay after heart rate changes in stress test” Cristina Pérez is a researcher from BSICoS. Research Group that coordinates NANBIOSIS ICTS Unit 27 “High Performance Computing”, led by PAblo Laguna (from I3A-UNIZAR and CIBER-BBN) Further information at BSICoS Websit[...] 24 Sep Researchers from BSICoS Research Group – NANBIOSIS U27 (from I3A-UNIZAR and CIBER-BBN presented their works in the Computing in Cardiology (CinC) Conference, held in Brno (Czech Republic) on 12-15 September. Diego García was Young Researcher Award (YIA) finalist with the work “Ventilatory Thresholds Estimation Based on ECG-derived Respiratory Rate”. The purpose of this work is to study the feasibility of estimating the first and second ventilatory thresholds (VT1 and VT2, respectively) by using electrocardiogram (ECG)-derived respiratory rate during exercise testing. The computation was performed by the ICTS NANBIOSIS, specifically by the High Performance Computing Unit of the CIBER-BBN at the I3A-University of[...] 23 Sep Researchers of Nb4D group – Unit 2 of the ICTS NANBIOSIS (led by Pilar Marco, from CIBER-BBN and the IQAC-CSIC) have participated in Expoquimia 2021, the International Chemistry Meeting, which took place from 14 to September 17 at the Fira de Barcelona.The researchers presented their work in several projects: the FoodSmartPhone project (MSCA-ITN-720325 action), the QS4CF (RTI2018-096278-B-C21), the QS-Motion (TV32018-201825-30-31) and on the PoC4CoV project (PIE-202050E090; PTI Salud Global, CSIC). Research at the FoodSmartPhone(MSCA-ITN-720325 action) is focus on developing devices for the monitoring of contaminants of interest in food safety through the use of mobile phones. The production of t[...] 20 Sep The European Researchers’s Nigth is a public event dedicated to the dissemination of science that is held every year in more than 300 cities in 30 countries of Europe at the same time, organized on the last Friday and Saturday of September. This year face-to-face activities are progrmmed in different locations of Catalonian cities and also the “Nit de la Recerca” YouTube channel offers more than 20 noves microxerrades led by researchers from Catalonia. Two NANBIOSIS’ researchers have joined this event to explain their research: Julian Guercetti – Nb4D Group – NANBIOSIS U2 CAbS, from IQAC-CSIC and CIBER-BBN, will giv[...] 15 Sep Pilar Marco, the Scientific Director of NANBIOSIS U2 , Custom Antibody Service (CAbS), and leader of the group Nanobiotechnology for Diagnostics (Nb4D) from CIBER-BBN and IQAC-CSIC, coorganises the European Biosensor Symposium digital seminar series. The aim of these seminar series is to continue with the purpose of the European Biosensor Symposium, held in March 2021, to allow especially juior reseachers to present their research, exchange ideas and built networds. The seminars are scheduled on the third Tuesday of every month at 18:00 CET, via zoom. Each of the seminars is organized by a host focussing on a specific topic: “Interferometric sensors“, hosted[...] 11 Sep Cáceres, September 10th, 2021 In the framework of the project “Updating the Infrastructures and implementation of a LIMS document control and management system to enhance the capacities of the Distributed ICTS NANBIOSIS Units managed by the CCMIJU (AILIMS-NANBIOSIS) a filtered air shower for Animal Housing has been bought with strictly controlled environmental parameters, to prevent possible cross-contamination and the entry of pathogens and viral particles, since during entry and exit of personnel to this area, contamination by the mentioned particles has been detected, so the air shower is an effective solution to eliminate them and protect the controlled environment. AILIMS[...] 10 Aug We are delighted to announce the publication of our new brochures which reflects the new equiments and capabilities incorporated to NANBIOSIS U16 Surface Characterization and Calorimetry Unit. The equipment is available has been incorporated to the Unit thanks to European Regional Development Fund (FEDER) allocated by the Goberment of Spain for the development of ICTSs, specifically through the Project FICTS-1420-14-09. TOFSIMS_EN-1Download Profilometry_ENDownload Goniometer_ENDownload Further information: NANBIOSIS News[...] 04 Aug Breast cancer is the leading cause of death in women between the ages of 20 and 59, and despite the fact that its diagnosis and treatment have improved greatly in recent years, relapses and resistance to treatment leave some young patients without a therapeutic option. . Tumor stem cells, from which the rest of cancer cells derive and are the cause of the most aggressive cancers, are especially resistant to conventional cancer treatments. In this line, researchers from the CIBER-BBN of the Drug Delivery & Targeting group and NANBIOSIS U20 at the Vall d’Hebron Research Institute (VHIR),, have developed a[...] 30 Jul On 15-16 noviembre 2021 will be hold the annual Conference of CIBER-BBN and NANBIOSIS CIBER-BBN´s Annual Conference is the most awaited yearly event for our research community to gather and discuss over past year´s achievements as well as to be updated about emerging key technologies. Under this light, this year´s edition includes presentations of internal collaborative projects, three plenary talks given by acknowledged experts in the fields of Biosignal Analysis, Hybrid Nanomaterials and Drug Delivery and a session dedicated to COVID-19 and the most recent advances in the fight against it as for detection, prevention and therapy. Due to this[...] 27 Jul Researchers of NANBIOSIS U10 Drug Formulation unit of CIBER-BBN and UPV/EHU and NANBIOSIS U14 Cell Therapy unit and U24 Medical imaging unit at CCMIJU have participated in a research that proposes the use of encapsulated cardiosphere-derived cells (CDC), obtained from heart tissue, as regenerative cell therapy. “The encapsulation of the cells has been carried out in NANBIOSIS Unit 10, as well as the characterization of the cells (both encapsulated and unencapsulated) for their application in regenerative medicine (cardiac regeneration); and unit 14 of NANBIOSIS has obtained the cell model used for the study “ – Explains Kaoutar Ziani Akrirout, researc[...] 20 Jul Miguel Zea, researcher at GAB Group – Nanbiosis U8 Micro– Nano Technology Unit will defend hir PhD thesis on Friday 23 of July, at 11 am, at the Graus Room of the Faculty of Sciences and Biosciences of the UAB about “Inkjet printing technology is driving the innovation of sensors for point-of-care devices” Thesis directors: Gemma Gabriel and Eloi Ramon Further information and registration for the event, onñine, here Abstract: The ‘Inkjet printing’ technology is called to be the next generation of flexible electronics capable of performing functions that were only accessible with state-of-the-art microfabrication technologies. This is due, in part, to the versatility of digital,[...] 19 Jul José Vidal Gancedo, researcher from ICMAB-CSIC and CIBER-BBN is leading the project VIRADEN: “In vivo Studies of Radical Dendrimers as Contrast Agents for Magnetic Resonance Imaging“, one of the ICMAB Frontier Interdisciplinary Projects (FIP) 2021. The project aims to evaluate the new contrast agents for MRI based on organic radical dendrimers developed in his group, to substitute the currently used contrast agents based on toxic metals, with the final goal of obtaining useful contrast agents in the early detection of tumors José Vidal has explained NANBIOSIS participation in the project through Biomaterial Processing and Nanostructuring equipments of NANBIOSIS U6 counting wit[...] 14 Jul Judit Tomsen, researcher at Nanomol Group – NANBIOSIS U6 (ICMAB-CSIC and CIBER-BBN) will defend her PhD thesis on Thursday, 15 July 2021, at 11 am in an hybrid session, from the ICMAB Seminar Room “Carles Miravitlles”. Further information and Registration to attend the PhD Thesis defense via Zoom at ICMAB-website. Supervisors: Nora Ventosa (Scientific Director of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit and leader of Nanomol Group of CIBER-BBN- ICMAB-CSIC Elisabet González, Nanomol Group of CIBER-BBN – ICMAB-CSIC Abstract: Liposomes are lipid-based nanovesicles widely explored as nanocarriers for the transport of biomolecules or drugs of interest to the place of action, and for the development of new[...] 13 Jul We are delighted to announce the publication of our new corporate brochure which reflects NANBIOSIS’s main core competences. This fresh looking promotion material has been intentionally designed to emphasize our experience of join expertise and capabilities solving problems in biomedical research, focussing on quality, adaptability and excellence commitment. The NANBIOSIS’ Cutting-Edge biomedical solutions have been updated to offer a wider range of Integrated solutions to advanced challenges faced by biomedical researchers in the fields of tissue engineering, regenerative medicine, diagnostic and medical devices. The Cutting-Edge biomedical solutions offered by the ICTS NANBIOSIS have been organised drilling down on our key areas:[...] 12 Jul Jaume Veciana Miró, Director of NANBIOSIS, has been awarded by the Catalan Society of Chemistry in its 2021 edition of Awards in research, education and dissemination with the Prize to the Scientific Excellence for his scientific career.[...] 09 Jul From 30 August 2021 to 29 September 2021 Jesus Usón Minimally Invasive Surgery Centre (JUMISC) has organized an on line course on Procedures and Introduction to Mesenchymal Stem Cell Culture. The course is directected by Francisco Miguel Sánchez Margallo and run by researchers of NANBIOSIS U14 Cell Therapy Unit at JUMISC Stem cells are cells capable of differentiating into a wide variety of cell types and can be isolated from different tissues. They have regenerative and anti-inflammatory properties thanks to the secretion of paracrine factors. Currently, these cells are being widely used in clinical trials for the treatment of different diseases such as[...] 08 Jul Víctor Sebastián Cabeza, researcher of NANBIOSIS U9 Synthesis of Nanoparticles of CIBER-BBN and the Institute of Nanoscience and Materials of Aragón, INMA, has obtained a research grant in the XX National Contest of the Ramón Areces Foundation in the category of Life and Matter Sciences with a funding of € 112,000 for the development in 3 years of nanovesicles using microfluidic technology. As explained by Victor Sebastian “the characterization of the nanovesicles will be carried with the equiment and expertise of NANBIOSIS Unit 9 The project entitled “Engineering of extracellular vesicles-exosomes using microfluidic technology for its application in biomedicine: ExoFluidTT”[...] 07 Jul Ibane Abasolo, the Scientific Coordinator of NANBIOSIS U20 of the CIBER-BBN at the Vall d’Hebron Research Institute (VHIR), has been appointed new Scientific Director, replacing Simó Schwartz, who has recently assumed the Directorate of the Blood and Tissue Bank of Catalonia. With her, there are 11 women who are Scientific Directors of NANBIOSIS units (46%), with the incorporation of Nora Ventosa and Rosa Villa during the past year 2020. Ibane Abasolo has also been appointed IP of the CIBER group that coordinates unit 20 of NANBIOSIS. The female replacement in the leadership of the CIBER groups is one of t[...] 06 Jul Acute and chronic wounds are a growing global health problem. The incidence of non-healing chronic wounds has exponentially increased with the aging of the population and chronic diseases. It has been estimated that there is a 2% prevalence of chronic wounds in the general population, which is associated with an annual estimated cost of more than US$50 billion. Biomaterial-based treatments are helpful in improving small-sized and uncomplicated ulcers. Biologic molecules, named epidermal growth factors (EGFs) have demonstrated potent therapeutic efficacy along with limited side effects, however, exogenous EGF is rapidly cleared from the topical application site. Jaume Veciana, Nora Ventosa[...] 05 Jul There is a growing demand, coming from the scientific community, to carry out studies with animal models in the best conditions for them. For this reason, the need of implementing a new control and recording system of environmental conditions within the stabling rooms of the CCMIJU Animal Housing arises. The whole process and the awarded company, General de Instalaciones y Conservación S.L., have been published in the following link of the Public Sector Contracting Platform, within the framework of the project “Updating of the Infrastructures and implementation of a document control and LIMS management system to enhance the capacities of[...] 24 Jun The Public Sector Contracting Platform has published the awarding to the company “Depur GM Deseño e Obra S.L” to carry out the improvement works in the CCMIJU’s Animal Housing within the framework of the project “Updating the Infrastructures and implementation of a LIMS document control and management system to enhance the capacities of the Distributed ICTS NANBIOSIS Units managed by the CCMIJU (AILIMS-NANBIOSIS). For further details, please click here The mentioned project has been co-funded by the European Regional Development Fund (FEDER) through the Ministry of Science and Innovation within the framework of the Programa Operativo Plurirregional de España (POPE)[...] 21 Jun The Scientific Commission of ‘La Marató TV3’ has seleced the project entitled “Diagnosis and treatment of Sars-Cov-2 by triplex formation”, led by Ramon Eritja, Scientific Director of NANBIOSIS Unit 29 Oligonucleotide Synthesis Platform (OSP) from CIBER-BBN and IQAC_CSIC to be financed with € 398,750.00. Verónica Noé from the Fundació Bosch i Gimpera Universitat de Barcelona, the CIBERESP researcher Enrique Calderón Sandubete, from the Virgen del Rocío University Hospital and María Valeria Grazú Bonavía, from the Institute of Nanoscience and Materials of Aragón, INMA (CSIC- UNIZE) also participate in this project. The edition of this solidarity initiative promoted by the Corporació[...] 14 Jun The management of musculoskeletal pain is a key challenge due to the short duration of anesthetic effect produced by existing clinical treatments, in addition to their potential side effects. Researchers from the CIBER-BBN, the Institute of Nanoscience and Materials of Aragón (INMA), CSIC-University of Zaragoza and the Institute of Health Research of Aragón (IIS Aragón), in collaboration with researchers from the Faculty of Veterinary Medicine of the University of Zaragoza and with participation of NANBIOSIS Unit 9 Synthesis of Nanoparticles Unit, have developed nanogels loaded with nanocrystals of bupivacaine (an anesthetic commonly used in epidural anesthesia and in the contro[...] 03 Jun UAB Parkinson’s disease (PD) is a common neurodegenerative disorder caused by the death of dopaminergic neurons in a part of the brain (known as substantia nigra pars compacta), which leads to a deficit of dopamine (DA), one of the main neurotransmitters active in the central nervous system. Symptomatic treatment focuses on increasing the concentration of dopamine into the brain.However, dopamine is not directly administered, because it is unable to cross the so called blood-brain barrier, which prevents some of the substances circulating in the blood to penetrate into the nervous system. Thus, DA precursor levodopa (L-DOPA) –an amino-acid which participates[...] 01 Jun The Ministry of Science and Innovation has approved a call for ICTS for 37 million euros. Investment lines of the ICTS associated with the construction, development, instrumentation, equipment and improvement of scientific-technical capacities of the ICTS will be financed with the 100% of the eligible cost. This call is funded by the European Union Recovery and Resilience Mechanism. The Singular Scientific and Technical Infrastructures (ICTS) are large, one-of-a-kind facilities, which are dedicated to cutting-edge technological research and development of the highest quality, as well as promoting the transmission, exchange and preservation of knowledge, technology transfer and innovation. They are distributed[...] 27 May About 1% of the world’s population suffers from celiac disease, a complex and autoimmune disorder caused by ingestion of gluten and for which there is no treatment beyond its elimination from the diet. In Spain every May 27, the National Celiac Day is commemorated to publicize the disease and give visibility and support to people with celiac disease. The detection of gluten becomes a key element for celiac patients to control the disease, as well as for the food industry, whose regulation requires declaring its presence in food. In this line, a team of researchers coordinated by the professor of[...] 21 May A team of Spanish researchers coordinated by the professor of the Polytechnic University of Valencia (UPV) and scientific director of the CIBER-BBN and NANBIOSIS unit 26, Ramón Martínez Máñez, and the Valencian oncologist, co-coordinator of the Research Group of Biology in Breast Cancer of the INCLIVA Health Research Institute, of the Hospital Clínico de València, Ana Lluch, also belonging to the CIBER de Cáncer (CIBERONC), has developed a prototype of a new biosensor to help detect breast cancer in its phases earlier. The work has been published in ACS Sensors magazine. According to the latest data collected by the European[...] 20 May Cancer is one of the world’s leading causes of death, with over 18.1 million cases and 9.6 million deaths in 2018. One of the most successful drugs used in chemotherapy for the treatment of diverse severe cancers is 5-Fluorouracil (5-FU), however, one of the major problems described in clinical practice is 5-FU cell resistance. Resarchers of the Nucleic Acids group and the Colloidal and interfacial Chemistry Group of CIBER-BBN at IQAC-CSIC have collaborated in a research to inspect and test the ability of parallel G-quadruplexes to deliver floxuridine oligonucleotides into different types of cancer cells; finally, the internalization ability and[...] 16 May Josep Samitier, Coordinator of the Nanomedicine Platform (NanoMed) and Director of IBEC, as well as Scientific Director of NANBIOSIS unit 7 of Nanotecnology, of IBEC and CIBER-BBN, particiated in the XIV Annual Conference of Biomedical Research Technology Platforms was held on 11 and 12 May. The Conference counted with the presence of relevant public and private sector actors, and more than 700 registered participants. During the opening ceremony, was opened, among others, by the Minister of Science and Innovation, Pedro Duque, it was precisely emphasized the importance of investment in science and technology. In the words of Josep Samitier: “The healt[...] 12 May Recently, a transversal action of CIBER has been started, coordinated by Cristina Villena, made up of teams from 4 thematic areas of the CIBER (CIBERES, CIBERER, CIBER-BBN and CIBERONC) that has constituted a unit of the CIBER that has been incorporated into the new Platform of Biobanks and Biomodels of the Carlos III Health Institute (ISCIII). The CIBER unit has been selected in the call for ISCIII Platforms to support R+D+I in Biomedicine and Health Sciences of the Strategic Action in Health 2017-2020, which will finance the Platform of Biobanks and Biomodels and two more platforms on support to clinica[...] 10 May The Spanish National Research Council (CSIC) is publishing the White Papers of the 14 strategic themes established on the basis of their scientific impact and social importance. The pen access to the White Paper of the fifth Challenge, Brain, Mind & Behaviour, is now avaailable. The book is the result of the “CSIC Scientific Challenges: Towards 2030”, in which the institution tackles the main issues and priorities for the future. This book is coordinated by Jesús Marco de Lucas and M. Victoria Moreno-Arribas. Drs. Rosa Villa and Anton Guimera (Biomedical Applications Group, GAB and NANBIOSIS U8 Micro– Nano Technology Unit from CIBER-BBN and IMB-CNM-CSIC)[...] 05 May The researchers of NANBIOSIS U12, Nanostructured liquid characterization unit of CIBR-BBN and IQAC-CSIC, will participate in teaching and training students of the Master en Cosmética y Dermofarmacia, organized by Centro de Estudios Superiores de la Industria Farmacéutica (CESIF), from 17 May to 16 June 2021. Cosmetic manufacturing companies are committed to innovation, both in technological development and in the use of components in their formulations, adapting to new trends and user needs. Determination of colloidal stability, surface tension, particle size and rheological behaviour, among many others properties, is essential for the proper characterization and understanding the performance of cosmetic products.[...] 03 May The Spanish National Research Council (CSIC) is publishing the White Papers of the 14 strategic themes established on the basis of their scientific impact and social importance. The pen access to the White Paper of the fourth Challenge, New Challenges in Biomedicine and Health, is now avaailable. The book is the result of the “CSIC Scientific Challenges: Towards 2030”, in which the institution tackles the main issues and priorities for the future. This book is coordinated by Mario Delgado (Instituto de Parasitología y Biomedicina “López – Neyra”, Granada) and María Moros (Instituto de Nanociencia y Materiales de Aragón, Zaragoza). Drs. Rosa Villa (Biomedical Applications Group, GAB and[...] 29 Apr – Margarita del Val, Pilar Marco, Mario Mellado, Diego Ramiro and Iñaki Comas will disseminate, in a webinar through YouTube, the works on the disease, diagnosis and social impact– The platform investigates the new coronavirus in six areas: prevention, disease, containment and diagnosis, treatment and vaccines, social impact and communication Five experts from the Higher Council for Scientific Research (CSIC) will explain in a webinar broadcast on YouTube, on Wednesday, May 5 at 6:00 p.m., the results of a year of research at the CSIC on the SARS-CoV-2 coronavirus carried out by the Global Health Platform. In the session, titled[...] 29 Apr CCMIJU has organised the IV Course on Introduction to research and laboratory techniques in Biosciences, which wil take place at JUMISC from May, 3th to June 6th 2020 under the Direction of Javier García Casado, Scientific Director of NANBIOSIS U14 Cell Therapy and Francisco Miguel Sanchez Margallo Deputy Scientific Director of NANBIOSIS. Other researchers of NANBIOSIS Units offer their expertise as Beatriz Moreno Lobato, Scientific Diector NANBIOSIS U19 and Luis Dávila Gómez, Scientific Director of NANBIOSIS U22. The course include: KNOWLEDGE PILLS FOR RESEARCHEXERCISES AND CASE STUDIES IRNA and DNA: GENE EXPRESSION AND GENETIC STUDIES IN REPRODUCTION.EXERCISES / CASE STUDIES IIPROTEINS AND PROTEOMA: PROTEIN EXPRESSION STUDIES AND PROTEOMIC[...] 28 Apr María Jesús Ortiz i Aguayo, graduate in Chemistry from the Autonomous University of Barcelona (UAB), has been the winner of the First Dresselhaus Prize, organized by the Catalan Society of Nanoscience and Nanotechnology (SCN2), of the 2020 edition. The award recognizes the work “Development of a pH microsensor for the determination of hydrogen sulfide based on Inkjet Printing“, supervised by Maria del Mar Baeza Labat (UAB) and Gemma Gabriel Buguña, from the Biomedical Applications Group GAB and NANBIOSIS U8 Micro– Nano Technology Unit from CIBER-BBN and IMB-CNM-CSICThe student also did her TFG with Dra. Gemma Gabriel at the IMB-CNM. T[...] 27 Apr The project “Updating the Infrastructures and implementation of a LIMS document control and management system to enhance the capacities of the Distributed ICTS NANBIOSIS Units managed by the CCMIJU (AILIMS-NANBIOSIS) ‘has been co-funded by the European Regional Development Fund (FEDER) within the framework of the Pluriregional Operational Program of Spain (POPE) of Singular Scientific and Technical Infrastructures (ICTS) 2014-2020. The following actions are considered in the framework of the project: -Within Unit 22 or Animal Facility, the Installation and development of an environmental treatment-control system of the housing rooms, an Improvement and adaptation of the spaces for experimental models, t[...] 25 Apr Elena Alcalde‑Estévez, Patricia Sosa, Ana Asenjo‑Bueno, Patricia Plaza, Gemma Olmos, Manuel Naves‑Díaz, Diego Rodríguez‑Puyol, Susana López‑Ongil & María P. Ruiz‑Torres, are the authors of an article recently published in the Journal Scientific Reports, of Nature Research, ·mentioning the collaboration in the investigation of the ICTS “NANBIOSIS” U17 Confocal Microscopy Service of CIBER-BNN and the University of Alcalá. Uremic toxins (UT) increase in the serum in parallel with a decrease in the glomerular filtration rate and the development of sarcopenia in patients with chronic kidney disease (CKD). This study analyses the role of UTs in sarcopenia associated with CKD in different[...] 20 Apr The CIBER-BBN transfer program, with its call for transfer projects, has selected two projects for next year with the aim of promoting the transfer of scientific or technological results, derived from the research carried out by the CIBER-BBN groups, to the industrial sector. One of these projects selected is directed by Elena Aznar Gimeno, researcher from the group led by Ramon Martínez Máñez at the IDM-Polytechnic University of Valencia, together with an external group led by Javier Pemán García, from the La Fe Health Research Institute From Valencia. The project has been jointly financed by CIBER-BBN and a company interested[...] 18 Apr The Project ADVERT (Advanced Extracellular Vesicles for Enzyme Replacement Therapy) is a research valorisation project recently granted by CIBER. The project pursues to advance the development of extracellular vesicles as treatments for lysosomal diseases, specially to bring new therapies to treat FABRY disease. The ADVERT Project will count on the active particpation of two NANBIOSIS units of CIBER-BBN: Unit 20 of the ICTS NANBIOSIS at Vall d’Ebrón Hospital, led by Ibane Abasolo, who coordinates the project. Unit 1 Protein Production Platform (PPP), at the IBB-UAB, led by Neus Ferrer, throught the coordination in the project of José Luis Corchero. T[...] 16 Apr The Unit 25 of the ICTS NANBIOSIS will be enrolled, through its scientific coordinator Ana Paula Candiota, in a research valorisation project recently granted by CIBER: “Noninvasive MR-based ImagiNg of Immune sysTem action during glIoblastomA TreatmEnt (MR-INITIATE)” Such project has the aim to increase the TRL of therapy response follow-up methods in glioblastomas, using technological approaches performed at U25 of NANBIOSIS NMR: Biomedical Applications I The project will be financed with € 20,000. The CIBER-BBN transfer program The CIBER-BBN transfer program through its call for transfer and valorization projects has been designed to promote the transfer to the industrial sector[...] 15 Apr Cáceres, April 15th, 2021 The CCMIJU, as a beneficiary of the Innovative Public Procurement Program of the Ministerio de Ciencia e Innovación, through the project “Minimally Invasive Robotic Surgery Systems” (TREMIRS), will invest € 7,345,300 in the development of innovative solutions in surgical robotics to improve services provided to the patient, the surgeon’s ergonomics and offer greater benefits to the surgical team, thus achieving an increase in the quality of healthcare. This ambitious challenge, 80% co-funded by the European Regional Development Fund under the Programa Operativo Plurirregional de España (POPE) 2014-2020 and by the Consejería de Economía, Ciencia y Agenda[...] 09 Apr Xavi Illa, Gemma Gabriel, Mar Alvarez and Rosa Villa, researchers of NANBIOSIS ICTS U8 Micro– Nano Technology Unit (from CIBER-BBN and the IMB-CNM-CSIC). are co-authors of two reviews that summarise the latest efforts in organ-on-chip technologies to emulate in vitro microfluidic systems. These devices are an opportunity to evolve the fields of biofabrication and sensing technology. Organ-on-chip (OOC) technology has been an efficient tool in modern research to substitute laboratory mice and simulate tissue and organ-level physiology and function. In particular, these in vitro devices have been extensively applied to model the intestine, enhancing the research community’s knowledge about intestina[...] 07 Apr Sara Jiménez-Jiménez, Georgiana Amariei, Karina Boltes, María Ángeles García and María Luisa Marina have recently published an article in the Journal of Chromatography A, ·mentioning the collaboration in the investigation of the ICTS “NANBIOSIS” U17 Confocal Microscopy Service of CIBER-BNN and the University of Alcalá. The echocytotoxicity of racemic panthenol and dexpanthenol at different concentrations and exposure times in Spirodela polyrhiza has been studied using NANBIOSIS U17 Confocal Microscopy Service “Panthenol (racemic mixture) and its isomer dexpanthenol have been classified as toxic for the aquatic environment by the European Regulation (EC 1272/2008). These studies are based on the natural emission[...] 06 Apr A report from the Spanish National Research Council (CSIC) collects in open access the results of a year of research on SARS-CoV-2. The book ‘A global vision of the COVID-19 pandemic’ shows the responses and solutions obtained by the 300 research teams of the CSIC Global Health Platform. The Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) has participated in the preparation of the chapter ‘Actions in containment and diagnosis’: Specific mucosal protection against the entry of SARS-CoV-2 – Lluisa Coderch. The role of diagnosis in the face of the pandemic – by M.-Pilar Marco, Scientific Director of NANBIOSIS U2 Custom[...] 26 Mar Launch of the cross-european PHOENIX project, which will provide a new infrastructure available to research laboratories, SMEs and start-ups to facilitate the transfer of nano-pharmaceuticals from the laboratory to clinical practice. PHOENIX will have a duration of 4 years and a total budget of 14.45 million euros. Two CSIC Institutes, ICMAB (CSIC) and INMA (CSIC-UNIZAR), and one CSIC spin-off, Nanomol Technologies, participate in the project, will count with the expertise of NANBIOSIS unit 6 (from CIBER-BBN and ICMAB-CSIC), led by Nora Ventosa. PHOENIX is an innovation project funded by EU’s Horizon2020 Framework Programme aimed to provide services for the development, characterization, testing,[...] 21 Mar The Microbial Adhesion research group-NANBIOSIS ICTS U16 Surface Characterization and Calorimetry Unit of the University of Extremadura (AM-UEX)-, belonging to the CIBER-BBN, led by Maria Luisa González, is searching in natural products, specifically in propolis, compounds with antimicrobial activity to help fight infections associated with biomaterials.Medical devices have greatly improved healthcare. But biofilm-associated infections related to the use of these devices are a major clinical concern. Biofilms are understood as bacterial communities that adhere to the surface of the devices and are embedded in a polymeric matrix that they themselves produce. This supracellular social organization arises as a survival strategy[...] 20 Mar Researchers of two CIBER-BBN units of the ICTS (Singular Scientific and Technical Infrastructures) NANBIOSIS, led by Ibane Abasolo the U20 located in the VHIR and the U6 in ICMAB-CSIC have participated in a study to improve the treatment of lysosomal disorders. In recent years, enzyme replacement therapies (ERTs) based on the systemic administration of a functional version of the defective enzyme have gained clinical relevance as a treatment for lysosomal storage disorders (LSD). However, the systemic administration of these recombinant enzymes has negative aspects, such as their low stability and inadequate distribution to the affected organs that result in a[...] 18 Mar Within the framework of NeoCom2021 Jesús Lázaro, researcher of BSICoS group and NANBIOSIS U27 High Performance Computing form CIBER-BBN and I3A-UZ will explain how biomedical signal processing can be used to improve the current understanding of the functioning of biological systems, conditions related to the cardiovascular, respiratory, and autonomic nervous systems, as well as their interactions. Prof. Lázaro will review the progress of the WECARMON European Project whose objective is the development of a system for long-term monitoring (months / years) of patients with cardiorespiratory diseases. NEOCOM: As every year, the Territorial Demarcation of the COIT in Aragon and t[...] 16 Mar The Nanotoxicology Unit of CIBER-BBN ICTS NANBIOSIS (u18-nanotoxicology-unit), led by Ramon Mangues at the Research Institute of the Hospital de Sant Pau and the NABIOSIS (nanbiosis.es)Protein Production Platform (u1-protein-production-platform-ppp) led by Antonio Villaverde and Neus Ferrer Miralles of the Institute of Biotechnology and Biomedicine at the Autonomous University of Barcelona, have participated in the development of a novel drug delivery system able to achieve sustained release of proteins with intrinsic antitumor activity. This delivery system consists on inclusion bacterial bodies formed by recombinant fusion proteins that precipitate while being expressed in bacteria, acquiring an amyloid structure, but remaining functional. Thus,[...] 15 Mar Candidemia is an infection caused by fungi of the genus Candida that is associated with high complication rates with a mortality that can reach 40%. A group of researchers have managed to develop a new material that allows for the rapid detection of candidaemia, with a sensitivity that exceeds 90% and a specificity greater than 95%. Researchers from the CIBER-BBN (Center for Biomedical Research for Bioengineering, Biomaterials and Nanomedicine). the Polytechnic University of Valencia (UPV) and the La Fe Health Research Institute (IIS La Fe), with the participation of Unit 26 of NANBIOSIS NMR Biomedical Applications II, in collaboration wit[...] 13 Mar The Jesús Usón Minimally Invasive Surgery Center, CCMIJU, partner of NANBIOSIS, offer high quality training based on itslearning philosophy perfectly adapted to new teaching methodologies and to a more dynamic and interconnected world. The CCMIJU Campus responds to the new modalities of online training and education. Based on their interests and objectives, students choose the course to suit their level and learning pace, being able to interact with expert tutors through social networks. Emerging as a complement to face-to-face activity, the CCMIJU Campus offers high quality training adapted to new methodologies, and to a more dynamic and intercommunicated world. T[...] 11 Mar The collaboration of NANBIOSIS U8 Micro–Nano Technology Unit of the CIBER in Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN) at the IMB-CNM in the research carried out by scientist of Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS) and ICREA has bien acknowledged in the publication of the results by Science Advances. Rosa Villa and Xavi Illa have been in charge of the fabrication of the probes used, more specifically, neuroprobes were designed and manufactured with 16 Ti / Au microelectrodes (20 / 200nm) on flexible polyimide substrates with open areas to improv[...] 10 Mar Simó Schwartz Jr., Scientific Director of NANBIOSIS Unit 20 In Vivo Experimental Platform has been appointed as the new general director of the Bank of Blood and Tissues of Catalonia, replacing Enric Argelagués, who is leaving his post after 17 years as director. Argelagués was the promoter of the unification of blood banks that began in the eighties and culminated in the current Bank of Blood and Tissues of Catalonia. Simó Schwartz now assumes the executive management of the organization, which currently has more than 800 workers and its mission is to ensure that all people in Catalonia have t[...] 04 Mar A new study with participation of NANBIOSIS Unit 10 Drug Formulation unit of CIBER-BBN and UPV/EHU, has succeeded in preventing and reversing pulmonary fibrosis in experimental models with PLGA / PEI nanoparticles loaded with the GSE4 peptide. These results are the first step to study its possible antifibrotic effect in patients with idiopathic pulmonary fibrosis and other progressive fibrosing diffuse interstitial lung diseases that present altered telomere function. NANBIOSIS unit 10 has been responsible for the design and manufacture of biodegradable nanoparticles loaded with the peptide. The work is led by Rosario Perona and Leandro Sastre, researchers of CIBERER at[...] 03 Mar Xavier Illa, Anton Guimrea y Eduard Masvidal, researchers of the CIBER-BBN group GAB Lab at IMB-CNM led by Rosa Villa, are coauthors of a study recently published in “Nature Communication”, in which it is demonstrated that graphene-based active sensor arrays are a mature technology for large-scale application in wide frequency band neural sensing interfaces. NANBIOSIS U8 Micro– Nano Technology Unit has been used in the development of the research. This research has been carruied out within the framework of the European Project “Graphene Flagship. The scientists have developed a sensor based on CVD graphene that detects brain signals in a wide frequency[...] 01 Mar The CCMIJU, partner of NANBIOSIS leads a European consortium of 9 partners from Spain, Norway, Netherlands, Romania and Greece to carry out the Research Project entitled “Mixed Reality in Medical Education Based on Interactive Applications“-MIREIA, funded by the Erasmus+ Programme – Key Action 2 (KA2): Cooperation for innovation and the exchange of good practices – Knowledge Alliances. The consortium members will work together to develop an innovative methodology and tools to provide paedagogical content for customized training based on 3D models, such as anatomical models (with and without pathologies) built from real-patient cases (e.g. medical imaging studies) or virtual scenarios for basic training in[...] 26 Feb 28 February: International Rare Disease Day This is one of the major achievements of the European Smart4Fabry project, which is now coming to an end after four years of work.The results have been made possible by nanotechnology and the approach developed could be applied to other drugs in the future.The new drug improves on current treatments and helps reduce costs and improve patients’ quality of life. Barcelona, 26 February 2021.- The advance of nanomedicine opens up new possibilities in the development of drugs, such as the one recently developed for the rare disease Fabry, with improved efficacy compared to existing[...] 25 Feb Researchers of the Nanotoxicology Unit of the the CIBER-BBN ICTS NANBIOSIS (u18-nanotoxicology-unit), leaded by Ramon Mangues and Isolda Casanova at the Research Institute of the Hospital de Sant Pau and of the NANBIOSIS (nanbiosis.es) Protein Platform (u1-protein-production-platform-ppp) leaded by Antonio Villaverde and Neus Ferrer Miralles of the Institute of Biotechnology and Biomedicine at the Autonomous University of Barcelona, have developed a novel protein-Auristatin nanoconjugate that specifically targets CXCR4-overexpressing acute myeloid leukemia (AML) cells. It selectively accumulates in target cancer cells expressing this receptor and deliver the toxin Auristatin within their cytosol. There, Auristatin potently blocks microtubule polymerization, provoking mitotic catastrophe,[...] 23 Feb The new system for the rapid, economic and efficient diagnosis of COVID-19 devised by the Universitat Politècnica de València (UPV), the IIS La Fe and the CIBER-BBN is now ready for trials on clinical samples. Since the pandemic broke out, the group of Professor Ramón Martínez Máñez, a researcher at the IDM Institute of the UPV and scientific director of the CIBER-BBN and NANBIOSIS U26 RNM for Biomedical Applications I, has been working on an alternative for the diagnosis of COVID-19, based on nanoporous films. These materials are capable of storing an indicator that is released only in the presenc[...] 21 Feb Researchers at the Nanotoxicology Unit of CIBER-BBN ICTS NANBIOSIS (u18-nanotoxicology-unit), led by Ramon Mangues and Isolda Casanova of the Research Institute at the Hospital de Sant Pau and the Researchers of the NANBIOSIS (nanbiosis.es) Protein Production Platform (u1-protein-production-platform-ppp) led by Antonio Villaverde and Neus Ferrer Miralles of the Institute of Biotechnology and Biomedicine at the Autonomous University of Barcelona, have participated in the development of a novel protein nanoparticle that incorporates the Exotoxin of the bacteria Pseudomonas aeruginosa, capable of targeting lymphoma cells that overexpress the CXCR4 receptor. They internalize selectively in target cancer cells through CXCR4 receptor-mediated endocytosis du[...] 18 Feb Susana Vilchez, researcher at NANBIOSIS U12. Nanostructured liquid characterization unit of CIBER-BBN and IQAC-CSIC, is coauthor of an article recently published in the Journal of Molecular Liquids. “This work – explains Susana Vilchez – shows how structural and viscoelastic properties of a lipid colloidal gel can be altered by varying the ratio of charged lipids in the dispersion. These findings corroborate that the eventual formation of the gel and the morphology of its network is governed by the repulsive potential of the particles instead of the molecular composition of their membranes. Thus, the right control of charge balance in the system may[...] 16 Feb In the framework of the FEDER Program in ICTS 2019 14 50, a project related to the ICTS NANBIOSIS has been selected by the Ministry of Science, Innovation and Universities for co financing with FEDER funds of the European Regional Development Funds program. An agreement has been signed between Ministry of Science and Innovation and CCMIJU, institution for the co financing of the Project ICTS 2019 14 50 : Genética embrionaria en reproducción asistida (GENERA NANBIOSIS) in Unit 23. The total budget of the project amounts to € 98.000, with 80% financing with FEDER Funds. CCMIU is processing the necessary[...] 15 Feb Researchers of the Nanotoxicology Unit (u18-nanotoxicology-unit) led by Ramon Mangues and Isolda Casanova at the Research Institute of the Hospital de Sant Pau and the Protein Production Platform (u1-protein-production-platform-ppp), led by Antonio Villaverde and Neus Ferrer Miralles of the Institute of Biotechnology and Biomedicine at the Autonomous University of Barcelona, both belonging to the ICTS NANBIOSIS (nanbiosis.es) of the CIBER-BBN, have participated in the production of a novel Nanotoxin capable of selectively killing cancer cells which became resistant to chemotherapy. Development of cancer resistance frequently associates with the overexpression of the CXCR4 receptor. It is known that chemotherapy kills cancer[...] 11 Feb Today February 11 is the International Day of Women and Girls in Science, a day to raise awareness of the gender gap in science and technology. According to the United Nations, while yet women and girls continue to be excluded from participating fully in science, science and gender equality are vital to achieve the internationally agreed development goals, including the 2030 Agenda for Sustainable Development. Thus, in recent years, the international community has made a great effort to inspire and promote the participation of women and girls in science. NANBIOSIS wants to acknowledge the efforts made by scientific women who struggle every day to contribut[...] 09 Feb In the framework of the FEDER Program in ICTS 2014-2020, a projects related to the ICTS NANBIOSIS has been selected by the Ministry of Science, Innovation and Universities for co-financing with FEDER funds of the European Regional Development Funds program. An agreement has been signed between Ministry of Science, Innovation and CCMIJU, institution that houses NANBIOSIS U14, U19, U21, U22, U23, U24 for the co-financing of the Project ICTS-2019-14-46: “ACTUALIZACIÓN DE LAS INFRAESTRUCTURAS E IMPLEMENTACIÓN DE UN SISTEMA DE CONTROL DOCUMENTAL Y DE GESTIÓN LIMS PARA POTENCIAR LAS CAPACIDADES DE LAS UNIDADES DE LA ICTS DISTRIBUIDA NANBIOSIS (AILIMS-NANBIOSIS)” The tota[...] 04 Feb Colorectal cancer (CRC) has a high prevalence worldwide and resistance to conventional chemotherapies and tumor relapse are usually related with a population of cells with malignant properties – Cancer Stem Cells (CSC). Scientists of CIBER-BBN and VHIR have led a research with the goal not only to treat the primary CRC, but also eradicate CSC. For both purposes, the use of nanoparticles (NP) is a useful strategy. These “bullets” carrying a drug in its core, are able to reach tumor tissue due to its small size. Cancer cells, and in particular CSC, present at their surface receptors that could be specifically recognized[...] 04 Feb In the frame of the collaboration of three units of NANBIOSIS, researchers of CIBER-BBN Groups proposed a strategy to simultaneously deliver anticancer drug pairs, composed by a tumor-targeted protein nanoparticle and an antiproliferative drug, with specific activ-ity for the same type of cancer. These three units are: NANBIOSIS U1 Protein Production Platform (PPP), at IBB-UAB, led by Toni Villaverde y Neus Ferrer NANBIOSIS U18 of Nanotoxicology Unit, at Institut de Recerca. Hospital de la Santa Creu i Sant Pau, led by Ramón Manques and Isolda Casanova, and NANBIOSIS U29 Oligonucleotide Synthesis Platform (OSP) at IQAC_CSIC, led by Ramón Eritja and[...] 01 Feb We are glad to inform that registration is now open for the 12th Workshop on Magnetic Resonance Spectroscopy and Imaging (MRI/MRS) Applied to Laboratory Animals, organized by the Biochemistry and Molecular Biology Department (UAB) and the Nuclear Magnetic Resonance Facility, which is also part of the NANBIOSIS ICTS U25 NMR: Biomedical Applications I. Workshop will take place February 15-18th, 2021.This course combines a comprehensive series of lectures on the technology of Magnetic resonance spectroscopy and imaging (MRS/MRI) with hands-on laboratory sessions to provide practical demonstrations of key concepts and procedures for preclinical studies.Whether you are considering MRI as a researc[...] 31 Jan Dr. Simó Schwartz, Scientific Director of NANBIOSIS U20 and head of the “Drug Delivery and Targeting group” of CIBER-BBN and VHIR, toghether with Dr. Jaume Alijotas (VHIR), have promoted the creation of the Spin-off ·BSURE Medical· for the devlopment of products and services for the diagnosis, prevention and consultation of aspects related to treatments with all types of bioimplants. One of the objectives of the Drug Delivery and Targeting group is to carry out preclinical studies to determine the effects and toxicities of drug delivery systems, cell therapies and biomaterials. Studies chace been carried out through the Nanbiosis unit U20,[...] 28 Jan Researchers of NANBIOSIS U12. Nanostructured liquid characterization unit from CIBER-BBN and IQAC-CSIC have recently published an article entitled Encapsulation of BSA/alginate water–in–water emulsions by polyelectrolyte complexation in the scientific journal Food Hydrocolloids The research which results are published involves the encapsulation of drops of water-in-water emulsions, which could be used as vehicles for the administration of active principles. Characterization of emulsions and capsules was performed in the Unit 12 of NANBIOSIS Nanostructured Liquid Characterization Unit. Water-in-Water (W/W) emulsions were prepared in aqueous mixtures of an anionic polyelectrolyte (sodium alginate, NaAlg), with a globular protein (bovine serum albumin, BSA). This combination showed phase separation[...] 27 Jan Next Wedneday, February 3, 2021 will take place the on-line event Smart-4-Fabry Final Workshop. Smart-4-Fabry is a european project, coordinated by CIBER-BBN wich has been developed during four years. This project is a sign of cooperation at European level to boost nanomedicine development and translation to clinical stages. This project is also a clear example of the relevance of access to advanced research infrastructures as NANBIOSIS -ICTS. Four NANBIOSIS units have collaborated and contributed to Smart-4-Fabry development: U1 Protein Production Platform (PPP) at IBB-UABU3 Synthesis of Peptides Unit at IQAC-CSICU6 Biomaterial Processing and Nanostructuring Unit at ICMAB-CSICU20 In Vivo[...] 26 Jan The NanoBioCel Research group, led by Jose Luis Pedraz, from CIBER-BBN and UPV/EHU, group that coordinates the Unit U10 Drug Formulation of NANBIOSIS -ICTS, together with the Provincial Council of Álava and the Center for Technological Research and Development TECNALIA, have launched last Thursday, January 21, the new Center for Research in Advanced Pharmaceutical Development, which will be located in the Lascaray Building, on the Álava campus of the UPV / EHU. The objective of this center is to introduce new technologies in the pharmaceutical field and promote applied research in 3D Bio-printing, 3D Printing of medical devices and 3D[...] 25 Jan Researchers of BSICoS Group and NANBIOSIS ICTS U27 High Performance Computing from CIBER-BBN and I3A-UZ have published a new article in the scientific journal IEEE Transactions Biomedical Engineering. proposing a new method to estimate tidal volume during stress test based only on the electrocardiogram signal. Electrocardiogram (ECG) has been regarded as a source of respiratory information with the main focus in the estimation of the respiratory rate. Although little research concerning the estimation of tidal volume (TV) has been conducted, there are several ECG-derived features that have been related with TV in the literature, such as ECG-derived respiration, heart rate variability or respiratory rate. In this work, resarchers[...] 24 Jan Prof. Rosa Villa, Scientific Director of NANBIOSIS U8 Micro– Nano Technology Unit, and group leader of the research group of biomedical applications of ICNM–CSIC and CIBER-BBN, has participated in the program of National Radio of Spain “The Open Future: Biobots” led by Tato Puerto. Following the recent presentation by a team of American scientists of the design of “reprogrammable organisms”, halfway between a robot and a living being, that is, an extraordinary living machine made from frog cells, the program of National Radio of Spain called “Open Future” has dedicated a session to explain what are “Biobots” and to generat[...] 21 Jan Ramón Eritja, Scientific Director of NANBIOSIS Unit 29 Oligonucleotide Synthesis Platform (OSP) has just published a new book “Nucleic Acids Chemistry, modifications and conjugates for Biomedicine and Nanotechnology“, Anna Avinó, Scientific Coordinator of NANBIOSIS Unit 29 is also a writer of the book. The book “Nucleic Acids Chemistry” takes the most important aspects of the methodology of oligonucleotides synthesis, that is currently expanding by the endorsement of a dozen of new medicines, such as the first medicine based on interfering RNA for the control of LDL and cholesterol in blood that will facilitate the decrease of cardiovascular illnesses. The writing[...] 20 Jan Researchers of NANBIOSIS Unit 20 In vivo Experimental Platform of CIBER-BBN and Vall d’Hebron Research Institute (VHIR) have patented a peptide that, in comparison to the current standard treatment, is much faster, internalizes much more, and does not cause any toxicity. The membrane of a cell is an effective barrier that hinders the targeted delivery of molecules, such as therapeutic compounds. During the last years, several strategies have been developed to get the molecules into the cell interior but, in general, the methods developed still show a low efficacy and / or toxicity. “The use of therapeutic nanoconjugates such as[...] 12 Jan Researchers of Nanbiosis U8 Micro– Nano Technology Unit, from CIBER-BBN and IMB-CNM-CSCIC have published an article in Nature Communications on Graphene arrays for long-term and wireless mapping of epicortical brain activity. A collaborative work in the framework of the Brain Com and Graphene EU projects. The article mentions the participation of NANBIOSIS-ICTS. Graphene active sensors have demonstrated promising capabilities for the detection of electrophysiological signals in the brain. Their functional properties, together with their flexibility as well as their expected stability and biocompatibility have raised them as a promising building block for large-scale sensing neural interfaces. However, in order to[...] 11 Jan The Andalusian Center for Nanomedicine and Biotechnology (BIONAND) and the Center for Biomedical Research Network in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), both partners of NANBIOSIS, in collaboration with the International Registry of Skeletal Dysplasias of the University of California (Los Angeles) and Masaryk University, of the Czech Republic have described a new genetic disease of the skeleton using a precision medicine strategy. This disease consists of extreme bone fragility with lack of mineralization and skeletal deformation associated with joint dislocation and heart disease, as well as a lung deficiency that causes perinatal lethality -at the time of birth-. Using massiv[...] 10 Jan Miguel Zea, a member of the NANBIOSIS U8 Micro– Nano Technology Unit presents a video explaining his research is based on the manufacture and validation of electrochemical sensors in medical applications: –“Using InkJet printing I have made sensors in different plastics and paper. Also using a novel approach in each sensor. I have made two pH sensors using novel Platinum and polymer inks and also a cortisol sensor on paper”. With this video, Miguel Zea, participates in the second edition of ‘I investigate, I am CSIC’. It is a competition hold by The Spanish National Research Council (CSIC) for its[...] 09 Jan Konstantinos Mountris researcher from the BSICoS group of CIBER-BBN and I3A at the University of Zaragoza has been granted the Outstanding Young Researcher Award at the International Conference on Computational & Experimental Engineering and Sciences (ICCES) in relation with the work Radial Point Interpolation Mixed Collocation (RPIMC) Method for The Solution of Reaction-Diffusion Equation in Cardiac Eletrophysiology (for the simulation of myocardial infarction). This work was already recognized in the Congress of Computing in Cardiology (CinC) held recently where Konstantinos Mountris and Esther Pueyo have received the Maastricht Simulation Award (MSA). Konstantinos Mountris acknowledged the contribution of NANBIOSIS U27 High Performance Computing :“using the HPC services[...] 08 Jan A new Scanning Electron Microscope (Hitachi TM-4000 Plus II) has been installed at the Nanostructured liquid characterization unit of NANBIOSIS ICTS (Unit 12) of CIBER-BBN and IQAC-CSIC. An online seminar will be given by Susana Vilchez on January 14th at 12h to explain the various features, functions and capabilities of this new instrument, Tabletop Scanning Electron Microscope Hitachi TM-4000 Plus II, that is open for both internal and external users. Those interested in attending the seminar can contact unit 12 of NANBIOSIS: Scientific Director: Prof. Carlos Rodríguez cranqb@cid.csic.esScientific Coordinator: Jordi Esquena jemqci@iqac.csic.es[...] 07 Jan The laboratory of NANBIOSIS Unit 2 from IQAC-CSIC and CIBER-BBN has obtained the biosafety level 2 accreditation, which allows the laboratory to work with biological agents classified in the risk group 2. Biological containment level 2 (NBS2) laboratories are generally required to work with any derivative of human blood or other primates, body fluids (especially when they are visibly contaminated with blood), cell lines, or tissues in which has uncertainty about the presence of an infectious agent. Also, the group participates in the COVID project “Point-of-care tests for the rapid detection of SARS-CoV-2 (POC4CoV)”, funded by the CSIC. This project[...] 29 Dec Researchers of Nanbiosis U16 Surface Characterization and Calorimetry Unit of CIBER-BBN and University of Extremadura in Badajoz, are the authors of an article published by Materials Chemistry and Physics, The researchers studied the surface chemical information of thirteen used catheters that had remained in patients for two months, using the XPS technique with the purpose of this communication is to report.Compositional changes in relation to unused catheters provided information on the degree of the chemical degradation suffered. ATR-IR added information on the chemical characterization of the samplesand Scanning Electron Microscopy (SEM) analysis will advise on topographical changes. The XPS techniqu[...] 28 Dec Researchers of CIBER-BBN Units of NANBIOSIS: U29 Oligonucleotide Synthesis Platform (OSP) at IQAC_CSIC, led by Prof. Ramón Eritja and U10 Drug Formulation, at UPV-EHU, led by Prof José Luis Pedraz, are coauthors of an article published by International Journal of Pharmaceutics. Gene therapy strategies based on non-viral vectors are currently considered as a promising therapeutic option for the treatment of cystic fibrosis (CF), being liposomes the most commonly used gene carriers. Niosomes offer a powerful alternative to liposomes due to their higher stability and lower cytotoxicity, provided by their non-ionic surfactant and helper components. In this work, a three-formulation screening is[...] 22 Dec NANBIOSIS unit 16 Surface Characterization and Calorimetry Unit form CIBER-BBN and University of Extremadura offers the performance of tasks of physical-chemical characterization of surfaces using techniques such as ellipsometry, calorimetry, X-ray photoelectronic spectroscopy (XPS) and detection of secondary ions by means of mass spectrometry by time of flight (Tof-SIMS). Recently, new equipment acquired through the execution an investment of 1.3 million euros, cofinanced with FEDER funds, the Ministry of Economy and Competitiveness and Junta de Extremadura, Regional Ministry of Economy, Science and Digital Agency, througth the project FICTS1420-14-09. These equipments are a microdroplet and picodroplet contact angle goniometry system and[...] 21 Dec In 2020, the XIV CIBER-BBN Annual Conference took place for the first time in virtual format, which did not prevent the Bioengineering, Biomaterials and Nanomedicine groups of the CIBER from sharing the results and advances of their research as always. For the fourth year in a row one of sessions of the CIBER-BBN Conference was dedicated to the ICTS NANBIOSIS. Here is video summary of the main milestones and topics addressed this year.[...] 18 Dec In today’s society there is a great interest in developing new technologies that allow low-cost mass manufacturing, also called “rapid prototyping” or “additive manufacturing”. Rapid prototyping includes technologies such as sterolithography, 3D printing, laser sintering or printed electronics, among others. All of these share digital design and manufacturing from the consecutive addition of layers, that is, techniques that allow creating almost any shape or geometric feature in a very fast time.Printed electronics consists of printing inks on different types of substrates such as textiles, plastics, papers or films to make them “smart”. This technique is presented as an alternative to[...] 16 Dec Researchers from the CIBER-BBN have succeeded in developing detection systems for Pneumocystis jirovecii, an atypical fungus responsible for very serious pneumonia in immunosuppressed patients. These results, published in the journal Nanomaterials, are the result of collaboration between the CIBER-BBN groups led by Laura Lechuga, Ramon Eritja and Ramón Martínez Máñez, and the CIBERESP group led by Enrique J. Calderón. The researchers acknowledge the paricipation of three NANBIOSIS units of CIBER-BBN: Nanbiosis U29 Oligonucleotide Synthesis Platform (OSP), led by Ramon Eritja and Anna Avinó at IQAC-CSIC and Nanbiosis U4 Biodeposition and Biodetection Unit , led by Laura Lechuga at ICN2-CSIC, andNanbiosis[...] 15 Dec Untill 30 of June 2021, small and medium companies can ask for funded beamtime in different European light sources thanks to EU CALIPSOplus project The European project CALIPSOplus brings together 19 partners offering access to 14 synchrotrons and 8 FELs in Europe and the Middle East. This pilot transnational access scheme allows SMEs to access the best light source for their particular needs, irrespective of whether or not it is the closest light source. Leader: CELLS (ALBA Synchrotron) (Barcelona, Spain) Webpage: https://www.albasynchrotron.es/en/industry/services Email: industrialoffice@cells.es On December 17, 2020 – 12:00 – 13:00 Sincrotrón ALBA -ICTS is running a Webinar that will explain to companies how SMEs can[...] 13 Dec Ignacio García and Javier Bonet, researchers from the Nanoporous Films and Particles (NFP) group and Nanbiosis U9 Synthesis of Nanoparticles Unit of the CIBER-BBN and the Institute of Nanoscience and Materials Science at the University of Zaragoza have presented their work on the CADENCE project in a video of a minute of duration that has been submitted to the #QueSigalaCiencia scientific dissemination contest promoted by the CIBER-BBN. #QueSigaLaCiencia is a campaign on social networks that wants to explain to society, from an optimistic perspective, the importance of research and the work carried out by the research staff of the CIBER.[...] 12 Dec Judith Guasch, researcher from Nanomol group, coordinator of NANBIOSIS unit 6 of NANBIOSIS (CIBER-BBN / ICMAB-CSIC) is interviewed in Onda Cero Radio in the programme “De cero al infinito” con Paco de León, to talk about her recent research on hydrogels to mimic lymph nodes for cancer immunotherapy. You can listen the interview to Judith Guasch in this link, from minute 11: 33 to minute 29:35. In her interview, Judith Guasch explains her research on hydrogels to mimic lymph modes to grow more effectively T cells for cancer immunotherapy, about the patent, the costs of the cancer immunotherapy, and about the 3D bio-printing and scaling[...] 11 Dec Nb4D research group and NANBIOSIS U2 Custom Antibody Service (CAbS) of CIBER-BBN at the IQAC-CSIC, together with the company Droplite Technologies have obtained a Retos-Collaboration project funded by the Ministry of Science and Innovation, for the development of a biosensor for detection and rapid quantification of hormones, linked to in-vitro fertility treatments. NANBIOSIS U2 CAbS will be responsible for the production of highly sensitive monoclonal antibodies, counting on the experience in this field of Juan Pablo Salvador, project coordinator, Núria Pascual and Mª Pilar Marco. The measurement of the hormone estradiol is a key indicator, both of maturity and of[...] 10 Dec The EASIER Project “Technology-enhanced learning of surgical and interventional technical and non-technical skills”, co-founded by the Erasmus + Program of the UE, introduces an innovative paradigm for online learning of minimally invasive surgery (MIS). EASIER introduces an innovative paradigm for online learning of minimally invasive surgery (MIS) and interventional skills. CCMIJU, partner of NANBIOSIS, is part on the poroject and provides the tools to create pedagogically curated learning courses where students can train both their technical and nontechnical skills. The platform will provide seamless integration of third-party assets (box trainers, virtual reality simulators) that can be used to program simulator[...] 09 Dec On December 11 the I I3A Conference will take place (online). This Conference is a meeting whose main focus will be the Young Researchers Conference, which is now in its IX edition, and in which there will be scientific conferences that will complete the program. A day dedicated to highlighting the research work in I3A institute of University of Zaragoza. The BSiCoS group from I3A and CIBER-BBN, coordinator of NANBIOSIS U27 High Performance Computing will be at the I3A Conference, where participatien in the Young Researchers Meeting: – Pablo Armañac: The capacity of the baroreflex as an identification index of ICU[...] 08 Dec The pandemic has led companies and researchers to reorient their plans and projects to meet the demands of society. Different examples of these new challenges will be seen at the next Technology and Business Forum on Thursday, December 10, covering from new tissues, better masks, diagnostic tests, epidemiological models and clinical equipment … All this, from an analysis both from the perspective industrial and research. The Technological and Business Forum is organized by the Aragón Engineering Research Institute (I3A), the SAMCA Chair of Technological Development, CEOE-Aragón and the Zaragoza Chamber. On this occasion, it will be held online and it[...] 30 Nov This monday 30 of october has taken place the traditional ceremony of Rei Jaume I Awards in Valencia, granted to six professionals in research, science and economics. At the ceremony, the awards have been given to the winners of the six categories: Rei Jaume I Basic Research Prize 2020 to Fco. José García Vidal; Rei Jaume I Economy Prize 2020 to Diego Puga; Rei Jaume I Medical Research Prize 2020 to Miguel Beato del Rosal; Rei Jaume I Environmental Protection Award 2020 to Fernando T. Maestre; Rei Jaume I New Technologies Award 2020 to Laura Lechuga and Rei Jaume I[...] 29 Nov Las November 27 was held the ACCIO ceremony (on line this year due to the Covid Pandemic restrictions) of disclosure of new TECNIO accreditations. Aurea Rodriguez, Director of Business Innovation at ACCIO has welcomed the attendees to the event. Later, the TECNIO program Coordinator, Marta Peidro, presented the background and rationale for this accreditation for excellence groups in technology transfer in Catalonia. This year there have been five new groups from among all Catalan universities and research organizations, which have obtained the TECNIO accreditation for the first time, making a total of fifty-four groups accredited in 2020. The event continued[...] 26 Nov The U6 of NANBIOSIS (Biomaterial Processing and Nanostructuring Unit) has expanded its capabilities with 2 new equipment items for the characterization unit. Both equipment items will allow the characterization of some physico-chemical properties of different nanomaterials. The Zetasizer ULTRA is used to measure the particle size of dispersed systems from sub-nanometer to several micrometers in diameter, using the technique of Dynamic Light Scattering (DLS). Zetasizer systems are also used to analyze particle mobility and charge (Zeta potential) using the technique of Electrophoretic Light Scattering (ELS), and the molecular weight of particles in solution using Static Light Scattering (SLS). The Green[...] 26 Nov Yesterday, November, 25 took place, within the the program of the Ateneo of the EINA (School of Engineering and Architecture of Aragón), the online conference on “The Revolution of Nanomedicine” by Ramón Martínez Máñez. The Conference chair, Jesús Martínez de la Fuente, Principal Investigator of the BIONANOSURF group of CIBER-BBN and the Institute of Nanoscience and Materials of Aragón, introduced the guest, Ramón Martínez Máñez, Scientific Director of CIBER-BBN, highlighting “his creativity in the use of his systems and how he combines them with different diagnostic release systems, combining organic chemistry, surface chemistry, applications in biotechnology and giving way to[...] 25 Nov The U12 of NANBIOSIS (Nanostructured liquid characterization unit) has expanded its capabilities with a new equipment U12-E22. SEM Hitachi TM4000Plus II for morphological and dimensional characterization of solid samples Low vacuum Scanning Electron Microscopy with two electron detectors (secondary, SE, and backscattered, BSE). SE imaging provides a detailed information of the morphology of the sample and BSE gives information about the different components of the sample, based on the different atomic number (the higher the atomic number, the brighter the surface). The equipment can apply different vacuum levels (using a turbo molecular pump) with accelerating voltages between 5 and 20[...] 23 Nov The XXXVII Annual Congress of the Spanish Society of Biomedical Engineering (CASEIB) is taking place between November 25 and 27. This new edition of CASEIB, in virtual format is organized by the CIBER-BBN group of Biomedical Engineering at Valladolid Universitiy, led by Prof. Roberto Sánchez Hornero. Prof. Laura Lechuga, Scientific Director of NANBIOSIS U4 Biodeposition and Biodetection Unit, member of the advisoty committee of scientific experts (Multidisciplinary Working Group) to the Ministry of Science and Innovation in COVID-19 and coordinator of the European project CONVAT shall participate in the Roundtable I: Biomedical Engineering and COVID-19 November 26, 12:00 h Researchers of BSICoS[...] 22 Nov Researchers of NANBIOSIS U29 Oligonucleotide Synthesis Platform (OSP) from CIBERBBN at @IQAC_CSIC, led by Prof. Ramón Eritja, are the authors of an article published by Int J Biol Macromol. 2020, entitled “Influence of pH and a porphyrin ligand on the stability of a G-quadruplex structure within a duplex segment near the promoter region of theSMARCA4 gene”. Prof Eritja hightlighs the contribution to this work by Dr. Raimundo Gargallo from the University of Barcelona. The manuscript described the structural analysis of the promoter region of the SMARCA4 gene involved in ovarian cancer. This promoter region has an exceptionally long G-rich sequence.[...] 21 Nov The NanoBioCell group, led by Prof. Jose Luis Pedraz, participates in the European project Moore4medical. A project to accelerate innovation in emergencing medical devices with open tecnhology platforms. The NanoBiocel group, will focus on the lyophilization process of biopharmaceuticals and their use in microfluidic devices The NanoBiocel research group of the University of the Basque Country / Euskal Herriko Unibertsitatea, which is part of the CIBER BBN and the ICTS Nanbiosis through the U10 Drug Formulation Unit, and led by Professor Jose Luis Pedraz of the Faculty of Pharmacy, participates in the European project Moore4medical, which aims to accelerate innovation[...] 20 Nov Researchers from the I3A and the CIBER-BBN at the University of Zaragoza Esther Pueyo and Konstantinos Mountris have been interwiewed at the Radio program “Hoy por Hoy” LA SER in relation with their work from engineering and mathematics to understand the functioning of the heart when it is healthy and when a heart attack occurs, to provide clinical specialists with the tools needed to improve patient care. They do this through computing in cardiology using the instalations of the ICTS Nanbiosis U27 High Performance Computing Unit, with the creation of a virtual heart that allows the computer to reproduce t[...] 19 Nov The Bioaraba Health Research Institute has awarded Ainhoa González Pujana, a researcher at NanoBioCell and the Nanbiosis Platform through the U10 Drug Formulation (from CIBER-BBN and UPV-EHU), the award for the best doctoral thesis 2019 at the XXI Bioaraba Research and Innovation Conference, held last November 5 in Vitoria-Gasteiz. Along with the recognition, the award consists of an economic endowment of € 1,000 in funds for R + D + i. The thesis, directed by Professor Rosa María Hernández and Dr. Edorta Santos Vizcaíno, has been carried out in the NanoBioCel group of the Faculty of Pharmacy of the University[...] 18 Nov On November 25th, CIBER-BBN organized a new webinar on regulatory aspects of in vitro diagnistic (IVD) medical devices. The European Parliament, in 2016, approved the new regulations that redefined the development of In Vitro Diagnostic (IVD) methods, with the aim of providing a framework of greater safety and transparency for patients, and at the same time renewing the regulations in force in that moment. This conference is aimed at researchers from the Academy, or any professional interested in clarifying the most important changes in regulations for the development of IVD products. We will have the participation of experts from t[...] 17 Nov National and international leading researchers have addressed this Monday and Tuesday the main scientific advances and challenges in the areas of bioengineering, biomaterials and nanomedicine. For yet another year, the XIV CIBER-BBN Annual Conference, held online, has brought together all the scientific groups in this area of the ISCIII Center for Online Biomedical Research (CIBER). The conference was opened on Monday by the director of the ISCIII, Raquel Yottti, who highlighted the role of the CIBER-BBN investigation “to find answers to very complex problems, specifically this year in the field of the fight against the pandemic.” The scientific director of[...] 16 Nov The Scientific Director of NANBIOSIS U4 Biodeposition and Biodetection Unit Laura Lechuga, has been awarded the 2020 National Research Prize, the most important recognition in Spain in the field of scientific research, granted by the Ministry of Science and Innovation. The National Research Awards, created in 1982, aim to distinguish the merit of those researchers of Spanish nationality who are carrying out outstanding work in scientific fields of international relevance and who exceptionally contribute to the advancement of science, to the transfer of technology and the progress of humanity. These awards have a total amount of 300,000 euros, (30,000 euros[...] 13 Nov Researchers from the CIBER-BBN and NANBIOSIS are participating in a new project that aims to achieve the most effective, specific and economical pharmacological nanotherapy that allows delaying the death of retinal cells and subsequent loss of vision in hereditary retinal dystrophy. retinitis pigmentosa, regardless of the genetic defect causing the disease. In this project, coordinated by the researcher Regina Rodrigo, the ONCE and the Prince Felipe Research Center (CIPF) of Valencia collaborate, together with researchers from the CIBER of Rare Diseases (CIBERER) and the Manises Hospital in Valencia. On behalf of the CIBER-BBN, the scientific director, Ramón Martínez Máñez, together[...] 13 Nov The Nb4D group of CIBER-BBN and IQAB-CSIC, coordinator of NANBIOSIS Unit 2 Custom Antibody Service (CAbS), has been accredited with the TECNIO seal. This accreditation is the hallmark TECNIO granted by the Government of Catalonia, through ACCIÓ, to identify the developers and facilitators of differential technologies in Catalonia. TECNIO is the umbrella brand for catalan technology centres and university research groups dedicated to industrial research and technology transfer. ACCIO, CERTIFICATION, QUALITY MANAGEMENT SYSTEM[...] 12 Nov ICTS underpins the Spanish reputation for research excellence. In the picture: the new poster of the ICTS map in which NANBIOSIS facilities have been highlighed with a red square The term Unique Scientific and Technical Infrastructure (ICTS) refers to facilities, resources, or services for the development of top-quality cutting-edge research, as well as the communication, exchange, and preservation of knowledge, the transfer of technology, and promotion of innovation. They are unique or exceptional in their fields, with a high cost of investment, maintenance, and operation, and are of a strategic importance that justifies their availability to all actors in t[...] 12 Nov The Soft Matrials Lab at ICMAB-CSIC, run by Amable Bernabé (NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit, hosted from Monday, 5 October, to Wednesday, 7 October a course on “Characterization techniques for particulate materials”. The course was an introduction to different techniques to characterize nanoparticles and other particulate matter, including the basic fundamentals, sample preparation, practical examples and results interpretation. Due to the COVID-19 pandemic, the participants of the course were less than in previous years, and during the practical sessions the group was divided, so less people was at the same time inside the lab, and the safety measures could be kept. Theory: Dynamic Light[...] 11 Nov The CIBER-BBN researcher at the University of the Basque Country (UPV-EHU), Laura Saenz del Burgo, received, within the framework of the XXI Bioaraba Research and Innovation Conference, the award for the “Best Emerging Researcher 2020”. The researcher of the NanoBioCel group of the UPV / EHU, who belongs to the CIBER BBN and the U10 Drug Formulation of the ICTS of Nanbiosis, is an active part within the research group led by Jose Luis Pedraz and focuses her work in the areas of Regenerative Medicine , Tissue Engineering and 3D-Bioprinting. The conference was held at the Palacio de Congresos d[...] 10 Nov TRIANKLE is an EU Project to develop regenerative therapies for ankel injuries in which participate NanoBioCell Group and NANBIOSIS U10 Drug Formulation unit (from CIBER-BBN and UPV/EHU), led by José Luis Pedraz. The main objective is to reduce the time of recovery down to 50% andincrease the functionality ratios up to 10-15%. Research consortium is composed of 12 partners from 5 European countries and counts with a EU funding of €5.9M. It is expected that the results of the project will be very well received by potential patients, such as elite athletes and patients with osteoarthritis, through the outreac[...] 09 Nov José Becerra Ratia, Subdirector of CIBER-BBN and researcher of NANBIOSIS, has presented NANBIOSIS-ICTS at the online annual conference of CIBEREH research, which takes place from 9 to 11 of November 2020. José Becerra has explained an initiative of CIBER-BBN, already successfully launched with other CIBER thematic areas such as “seed projects” between research groups from two areas, in this case -BBN (Bioingniering, Biomaterials an Nanomedicine) and – EHD (Hepatic and Digestive Diseases) Professor Becerra has also presented CIBER-BBN as well as the opportunities offered by the ICTS NANBIOSIS as a Platform for Research and Biomedical Innovation. CIBEREHD counts with: 50 groups of[...] 08 Nov CCMIJU has organised the III Course on Introduction to research and laboratory techniques in Biosciences, which wil take place at JUMISC on December, 18th, 2020 under the Direction of Esther López Nieto and Javier García Casado, Scientific Director of NANBIOSIS U14 Cell Therapy. Other researchers of NANBIOSIS Units offer their expertise as Beatriz Moreno Lobato, Scientific Diector NANBIOSIS U19 and Luis Dávila Gómez, Scientific Director of NANBIOSIS U22 The course contents are distributed in the following blocks: Block I. Knowledge pills for research – TheoryResearch career and aid for hiring (Dr JG Casado). 30 minCommunication of research results (Dra. E López). 30 minIntroduction to[...] 08 Nov Jesús Santamaría, Scientific Director of NANBIOSIS U9, Synthesis of Nanoparticles Unit, runs for the elections to the Rectorate of the University of Zaragoza. Jesús Santamaría Ramiro, professor in the Department of Chemical Engineering and Environmental Technologies, at the Faculty of Sciences, has presented his candidacy to the Rectorate of the University of Zaragoza this week. The opinion group Proyecto Unizar, the germ of this candidacy, has also been presented. Proyecto Unizar, which motto is “Another University is possible” includes more than 60 members of the university community and more than a hundred supporters, among them, several members of CIBER-BBN NANBIOSIS Units in[...] 05 Nov During the month of October took place the Spanish Society of atherosclerosis (SEA 2020) Virtual meetings, promoted by Novartis. Prof. Ramon Eritja, Scientific Director of NANBIOSIS U29 Oligonucleotide Synthesis Platform (OSP) (from CIBERBBN at IQAC_CSIC), was the guess speaker in the session “Innovation and future therapeutic strategies in dyslipidemia” giving the conference entitled “How to take advantage of the body’s natural processes to create innovative therapies“, in the telematic congress of the Spanish society of atherosclerosis (SEA 2020) in the session “Innovation and future therapeutic strategies in dyslipidemia”.Dr. Ramon Eritja, explained the mechanism of action of some new drugs based[...] 04 Nov CIBER-BBN´s Annual Conference will take place from Monday, November 16, 2020 to Tuesday, November 17, 2020. This year´s edition includes presentations of internal collaborative projects, three plenary talks given by acknowledged experts in the fields of Biosignal Analysis, Hybrid Nanomaterials and Drug Delivery, a session dedicated to COVID-19 and the most recent advances in the fight against it as for detection, prevention and therapy and a session about the ICTS NANBIOSIS. Due to this year´s exceptional circumstances, XIV CIBER-BBN Conference will be held on-line. Access to broadcasted talks and subsequent debate is free following registration to the event https://jornadasanuales.ciber-bbn.es. Registration[...] 02 Nov The last edition of the program “Meridiano Turing” of RTVE interviews Maria Pilar Marco Head of CIBER-BBN and IQAC-CSIC group Nb4D and NANBIOSIS-ICTS Unit 2 Custom Antibody Service (CAbS), Cesar Fernández (Head of the Chemical Transducers Group at IMB-CNM, CSIC) and María Cruz Minguillón (EGAR group at IDAEA) Pilar Marco y César Fernández, the authors of the block of the CSIC’s report entitled “Containment and diagnosis“, explain wich is the best way to diagnose COVID and how reliable are the tests in this moment. What is needed is to detect an infection -says Pilar Marco- is viral material and w[...] 23 Oct CLINAM, the European Foundation for Clinical Nanomedicine will celebrate on October 26 – 28, 2020 the 12th European and Global Summit for Nanomedicine with the subject Clinical Nanomedicine and the Impact of Digitalization and Artificial Intelligence for Precision Medicine. The Technologies for Diagnosis & Therapy in Patient-Centric Medicine The Conference will take place in Live Stream, due to the COVID-19 pandemic. NANBIOSIS will participate in the Virtual Enhibition and in the poster session with a poster “Cutting Edge Biomedical Solutions in Health for Translation into Clinics”. Also Prof. Simó Schwartz, Scientific Director of NANBIOSIS U20 In vivo Experimental Platform, will giv[...] 22 Oct The research group of Chemical Multivalent Systems for Nanomedicine and NANBIOSIS U3 Sinthesys of Peptides Unit, of IQAC-CSIC and CIBER-BBN, participates in a new project that seeks to develop molecules with neutralizing properties of SARS-CoV-2, the cause of the COVID-19 disease, for the treatment of patients requiring hospitalization and clinical supervision due to the severity of the infection. The project, led by the Public University of Navarra (UPNA) and Navarrabiomed, counts with the participation of researchers from institute of advanced chemistry of catalonia (Institute of Advanced Chemistry of Catalonia), IRB Barcelona (Institute for Biomedical Research), CIBER-BBN (Center for Networked Biomedica[...] 21 Oct Researchers of NANBIOSIS Unit 8 Micro– Nano Technology Unit at the Microelectronic Institute of Barcelona, (of IMB-CNM, CSIC / CIBER-BBN) has recently published a review in the TrAC Trends in Analytical Chemistry entitled “Electrochemical sensors for cortisol detections: Almost there” highlighting: Overview of electrochemical techniques for cortisol detection published in the last five years. Recent advances in cortisol detection by electrochemical immunoassays. Potential of biosensing techniques for cortisol detection in biological matrices. Importance of cortisol quantification for clinical applications. Abstract Mostly known as “the stress hormone”, cortisol has many essential functions in humans due to its involvement in regulation of[...] 20 Oct The Valencian Government (Generalitat Valenciana), together with the Foundation Premios Rei Jaume I, announced today the awardees of the 32th edition of the Rei Jaume I Awards, one of the highest recognitions for a research career in Spain. Prof. Laura M. Lechuga Gomez, Full Professor of the Spanish National Research Council (CSIC), head of the NANBIOSIS U4 Biodeposition and Biodetection Unit and the Nanobiosensors and Bioanalytical Applications Group (of CIBER-BBN and the ICN2), has received the New Technologies Award. Prof. Laura M. Lechuga received her PhD in Chemistry from the University Complutense of Madrid (Spain) in 1992. The principal focus of her researc[...] 19 Oct Guillem Vargas Nadal, researcher at Nanomol Group – NANBIOSIS U6 (ICMAB-CSIC and CIBER-BBN) and Nanomol Technologies will defend his PhD thesis on Friday, 23 October 2020, at 11 am in an online session. The PhD Thesis Defense will be held by videoconference from the ICMAB Meeting Room. Further information and Registration to attend the PhD Thesis defense via Zoom nanoparticles at ICMAB-website. Supervisors: Nora Ventosa (Scientific Director of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit and leader of Nanomol Group of CIBER-BBNLidia Ferrer (Nanomol Technologies S.L.) Abstract: The nanovesicles are being developed and investigated to be used in the pharmaceutical world to deliver drug and detect[...] 18 Oct The organizing committee and jury of the seventh edition of the Ada Byron Prize for Technological Women, from the Faculty of Engineering of the University of Deusto, have awarded the 2020 award to Prof. Laura Lechuga Scientific Director of Nanbiosis U4 Biodeposition and Biodetection Unit of ICN2-CSIC and CIBER-BBN. Laura Lechuga has a degree in Chemical Sciences and is currently a research professor at the CSIC of Barcelona, Head of the Group of Nanobiosensors and Bioanalytical Applications. Her research area focuses on Nanomedicine, Nanodiagnosis and the technological development of nanophotonic biosensors and their integration into portable Point-of-Care (POC) platforms, as[...] 16 Oct BSICoS Group at I3A- University of Zaragoza –NANBIOSIS U27 High Performance Computing offer a FULLY-FUNDED PhD FELLOWSHIP Applications must be submitted before October 27th, 2pm (Spain time). Profile of the candidate:Graduate/Master in Mathematics, Physics, Engineering or related disciplines. PhD contract and topic:A PhD contract (former FPI program) is offered for a PhD position at the Biomedical Signal Interpretation and Computational Simulation (BSICoS) group of the Aragón Institute of Engineering Research, University of Zaragoza.The PhD thesis is associated with the research grant “Towards improved management of cardiovas-cular diseases by integrative in silico-in vitro-in vivo research into heart’s structure, function and autonomic regulation”, funded by[...] 09 Oct #Quesigalaciencia is an initiative of the Centro de Investigación Biomedica en Red (CIBER), partnert of NANBIOSIS) to convey, from the optimism, the importance of continuing to research. From this initiative, CIBER researchers are encouraged to disseminate videos explaining their work and why it is important. The campaign will begin during the Madrid Science Week, but will continue later. To participate, consult the terms of the call The deadline for the call # QuéSigaLaCiencia is October 13 The Science and Innovation Week in Madrid is an event for scientific dissemination and citizen participation that aims to actively involve citizens in science, technology and innovation[...] 09 Oct ETPN2020, the 15th annual event of ETPN, European Technology Platform on Nanomedicine will take place, fully virtual on Oct. 14-15 to share the latest trends and success stories in Nanomedicine and emerging Medtech. In the frame of ETPN2020, on thursday Oct, 15, 12:00 will tak place the Workshop “Translational issues in nanomedicine” the workshop “Translational issues in nanomedicine” organized jointly by ETPN2020 and NMBP projects. Nora Ventosa, Scientific Director of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit, will participate as coordinator of the european project Smart 4 Fabry The workshop chairs will be Fabrice Navarro (Head of Laboratory at CEA[...] 08 Oct Ramón Martinez, Scientific Director of CIBER-BBN and NANBIOSIS unit 26 NMR: Biomedical Applications II is interviewed by Spanish Television about the research he is coordinating at the Polytechnic University of Valencia to develop new tests as an alternative to PCR. Dr. Elena Aznar CIBER researcher at IQMA-IDM-UPV group explains how work these test that allow to diagnose quickly, easily, reliably and cheaply if a person is or has been infected by the SARS-COV-2 virus. Ramón Martínez Máñez, leader of the project, reports on the point where the investigation is, as well as the difference of these tests with PCR or[...] 06 Oct An article by Sara Larriba of the Human Molecular Genetics Group of Bellvitge Biomedical Research Institute (IDIBELL), recently published by the International Journal of Molecular Science. entitled “Impact of Extracellular Vesicle Isolation Methods on Downstream miRNA Analysis in Semen: A Comparative Study“, acknowledges NANBIOSIS ICTS for its participation in the research results. The nanoparticle tracking analysis was performed by the ICTS NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit. Abstract: Seminal plasma (SP) contains a unique concentration of miRNA, mostly contained in small extracellular vesicles (sEVs) such as exosomes, some of which could be clinically useful for diagnosis and/or prognosis of urogenital diseases[...] 05 Oct Judit Morlà Folch, CIBER-BBN Researcher in Nanomol Group and NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit at ICMAB-CSIC is giving the seminar “Nanoprobes for the next generation of Optical Imaging“, today Monday, 5 October 2020 at 12 pm, Hosted by Nora Ventosa, Nanomol Group in the cycle of Online ICMAB PostDoc Talk. Online Invited Seminar by Zoom. Register here to attend. About the Seminar: Molecular imaging plays a vital role in the healthcare sector, since abnormal conditions and diseases are often diagnosed through imaging, while therapeutics methods used for the treatment of the abnormalities are often guided by imaging. Optical imaging[...] 02 Oct The report by Spanish Higher Council for Scientific Research (CSIC) summarizng the most relevant scientific results on the Covid-19 pandemic. “A global vision of the Covid-19 pandemic: What we know and what we are investigating from CSIC”, has just published its version number 4. This report is structured in five blocks: prevention, disease, containment and diagnosis, treatment and vaccines, and global impact. The containment and diagnosis block describes how the virus is transmitted in the air indoors and the analysis of wastewater as a system for early detection of SARS-CoV-2 is explained. In addition, the importance of diagnosis in t[...] 01 Oct CCMIJU has organised the XIV Course of Laparoscopic Surgery of Colon, which wil take place at JUMISC from 14 December to 16 December 2020 under the Direction Francisco Miguel Sánchez Margallo (Deputy Scientific Director of NANBIOSIS) Two of the main lines in the activity of the Minimally Invasive Surgery Centre (CCMIJU) are the Innovation and medical training in collaboration with hospitals and companies of the medical sector, with the aim to improve the quality of healthcare delivered to patients, by providingsurgeons and other health professionals with innovative solutions andtraining. The CCMIJU is part of the Singular Scientific-Technical Facility(ICTS) NANBIOSIS, featuring state-of-the-art technology to beused[...] 30 Sep Researchers from NANBIOSIS U12 Nanostructured liquid characterization unit, from CIBER-BBN at the IQAC-CSIC have chemically modified contact lenses, incorporating antibacterial properties. Contact lenses, especially soft ones, pose a risk of ocular microbial infection that can eventually lead to loss of vision. “These new contact lenses inhibit the formation of bacterial biofilms and could prevent ocular keratitis” explains Jordi Esquena, a researcher at the CIBER-BBN at the IQAC-CSIC and one of the coordinators of the work. In the study, published in Colloids and Surfaces B: Biointerfaces, bactericidal activity was introduced into hydrogel contact lenses, through antimicrobial peptides that were anchored on[...] 29 Sep PCR (acronym in English for “Polymeric Chain Reaction”), is a type of diagnostic test for the detection of infectious diseases. The PCR diagnosis of COVID-19 used since the outbreak of the pandemic offers a high level of specificity and sensitivity but presents a certain degree of complexity, requiring specialized personnel and is expensive. Researchers from Polytechnic University of Valencia (UPV), the Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (FISABIO), the La Fe Health Research Institute (IIS La Fe) and the consortium Centro de Investigación Biomédica en Red de Bioengineering, Biomateriales y Nanomedicina (CIBER-BBN) has[...] 28 Sep Researchers of CCMIJU and NANBIOSIS Unit 14 Cell Therapy, led by Javier García Casado, have recently published a study with the purpose to combine stem cell therapy and laparoscopy for the treatment of congenital hernia in a swine animal model proposing an easy and feasible method to combine stem cell therapy and minimally invasive surgical techniques for hernia repair, the first preclinical study evaluating the use of stem cell therapy in the field of abdominal hernias in a clinically relevant swine model with congenital hernia Surgical procedures and imaging diagnoses were performed at the ICTS NANBIOSIS Unit 21 Experimental operating[...] 23 Sep An accurate and explanatory review recently published in ACS Sensors. led by Prof. Laura Lechuga, Scientific Director of Nanbiosis U4 Biodeposition and Biodetection Unit from CIBER-BBN and ICN2, discusses current diagnostic techniques for COVID-19 and possible future developments in this field. In particular, after highlighting the advantages and limitations of the methods available at present, the article introduces optical biosensors and illustrates how nanophotonic label-free devices can contribute to meet the emerging needs in this context. For further information at ICN2 website Reference article: Maria Soler, Maria Carmen Estevez, Maria Cardenosa-Rubio, Alejandro Astua, and Laura M. Lechuga, How Nanophotonic Label-Free Biosensors Can Contribute to Rapid and Massive Diagnostics of Respiratory[...] 22 Sep NANBIOSIS has participated in the organization of the on-line Conference on Nanotoxicity in collaboration with, CIBER-BBN, Nanomed Spain and Materplat, to debate about the efect of nanotoxicity of nanoparticles and nanotechnologies in health. The session has been started by Ramon Martinez Mañez, Scientific Director of CIBER-BBN and NANBIOSIS U26 NMR: Biomedical Applications II. Isabel Rodriguez (GAIKER Technlogy Center) has taking about tools for risk management of nanomatials differentiating between tools and strategies and explaining their experience in studies carried out. Luis Rojo del Olmo investigador del Grupo de Biomateriales del Instituto de Ciencia y Tecnología de Polímeros del CSIC y del CIBER-BBN) has spoken[...] 21 Sep The 4th Annual IQAC Symposium will take place on September 23, 2020. This year will be dedicated to the research projects on COVID-19 that are being carried out in the IQAC-CSIC. It will be a dissemination day aiming to inform the general public about some of the lines of research that are currently being developed in the fight against the COVID-19 pandemic. The event will be live streamed in Facebook: facebook.com/iqac.csic.es/ Three of the speakers, members of CIBER-BBN NANBIOSIS units at IQAC-CSIC, will explain their work. Pilar Marco and Roger Galve (NANBIOSIS U2 Custom Antibody Service (CAbS) will talk about[...] 18 Sep Researchers from Bionand, partner of NANBIOSIS and the University of Malaga toguether with Red de Terapia Celular, CIBER-BBN and CIBER-NED have taken another step in the search for new rapidly implantable therapies to stop the pandemic caused by the coronavirus disease, identifying a new drug that could prevent or mitigate the consequences of the SARS-CoV-2 infection. The team, led by UMA researchers Iván Durán and Fabiana Csukasi, will study over the next year how treatment with 4-Phenylbutyrate (4-PBA) modulates the inflammatory response that occurs in the most severe cases of COVID-19. The first results have already been published in t[...] 17 Sep The Jesús Usón Minimally Invasive Surgery Center (JUMISC), partner of NANBIOSIS, will develop an R&D project aimed at alleviating the effects of the health and social crisis of COVID-19, thanks to a collaboration agreement with Banco Santander. The project “Analysis of ligands for SARS-CoV-2 in lymphocyte subpopulations with application for disease staging and patient stratification“, will be developed for a year with the collaboration of researchers from from the San Pedro de Alcántara Hospital in Cáceres, the University of Extremadura, the Reina Sofía Hospital and Mount Sinai in New York. This research initiative aims to provide a reliable prediction of[...] 16 Sep Konstantinos Mountris and Esther Pueyo, (NANBIOSIS Unit 27 High Performance Computing), have been awarded with the Maastricht Simulation Award for their participation in the CinC 2020. Researchers of BSICoS Group, from CIBER-BBN and I3A of Zaragoza University, have participated in the 47 Computing in Cardiology Conference, which took place in Rimini, Italy, during the days 13-16 of September. Alba Martín, was awarded with the Best Remote Poster Presentation for the poster entitled “Model-based characterization of atrial fibrilation episodes and its clinical association“. And the work “Next-generation in-silico Cardiac Electrophysiology through Immersed Grid Meshfree Modelling. Application to Simulation of Myocardial Infarction”[...] 15 Sep JOINT OITBS OPEN CALL TO FIGHT COVID 19 SAFE-N-MEDTECH OITB project in which CIBER-BBN is a partner througth its ICTS NANBIOSIS, gathers expertise from 28 partners around the World focused in enabling the safe translation of nano-enabled medical technologies from Proof of Concept to markets and clinical practice. The sudden COVID-19 outbreak has meant an unforeseen challenge that requires rapid answers from the Science, Technology and Innovation Community. These is a framework where SafeNMT could deploy all its potential: first, because nanotechnology is a Key Enabling Technology that can contribute to innovative approaches to fight COVID 19 and/or other vira[...] 10 Sep Scientists of CIBER-BBN, Ana Paula Candiota and Margarida Juliá managing Nanbiosis ICTS U25 NMR: Biomedical Applications I have participated in the research carried out by Liverpool John Moores University and University of Valencia to elucidate associations between brain tumours and metabolites, published by the journal Plos One. The aim of the paper is two-fold. First, to show that structure finding with the PC algorithm can be inherently unstable and requires further operational constraints in order to consistently obtain models that are faithful to the data. The authors propose a methodology to stabilise the structure finding process, minimising both false positiv[...] 07 Sep The Higher Council for Scientific Research (CSIC) has prepared a report that summarizes the most relevant scientific results on the Covid-19 pandemic. The document compiles results of international research and projects in execution of the 300 research groups of the CSIC Global Health Platform. The report, entitled “A global vision of the Covid-19 pandemic: What we know and what we are investigating from CSIC“, is structured in five blocks: prevention, disease, containment and diagnosis, treatment and vaccines, and global impact. Researchers of NANBIOSIS-ICTS units and CIBER-BBN at CSIC Centres participate in the researches carryed out and in the report. This[...] 24 Aug NANBIOSIS, U4 Biodeposition and Biodetection Unit has expanded its capabilities with two upgrades: Upgrade of UV / Ozone cleaner for NanoeNabler and Upgrade of the optics and the microfluidic components of the Biodetection Unit (SPR biosensor) This upgrade and new equipment have been confinanced by the European Regional Development Fund (ERDF) through the Plurirregional Operational Program of Spain (POPE)2014-2020[...] 18 Aug The on line Conference ATTRACT – Igniting the Deep Tech Revolution will take pace on 22-23 Sep 2020. The ATTRACT Online Conference website is now live! Please register before 28 August at https://attract-eu-conference.cern.b2match.io/ The ATTRACT Conference offers multiple opportunities to understand the dynamics and contribute to the emergence of a strong European deep tech ecosystem for detection and imaging technologies. The ATTRACT Project is an EC funded initiative led by a consortium of leading European research infrastructures and universities. CIBERBBN and Nanbiosis are involved in MAGRes : Multiparametric MR approaches for non-invasive glioblastoma therapy response follow-up, one of the 170 projects using sensing and imaging technologyto[...] 17 Aug The Academic Ranking of World Universities (ARWU), known as Shanghai Ranking, which was made public on August 15, once again places the University of Zaragoza among the elite of the 500 best universities in the world. This indicator organizes up to 20,000 university centers worldwide. Among the keys that have been able to positively influence the results of the research, according to the Vice Chancellor for Prospect, Sustainability and Infrastructure of the University of Zaragoza, Francisco Serón, are the increase in public campus funding for four years as well as the quality of their Scientists. The University of Zaragoza houses[...] 17 Aug The Academic Ranking of World Universities (ARWU), known as Shanghai Ranking, which was made public on August 15, places the Autonomous University of Barcelona among the elite of the 300 best universities in the world and the first of the Spanish universities. This indicator organizes up to 20,000 university centers worldwide, based on transparent methodology and objective third-party data. ARWU is regarded as one of the three most influential and widely observed university rankings The Autonomous University of Barcelona houses two of NANBIOSIS Units: U1 Protein Production Platform (PPP), led by Toni Villaverde, Neus Ferrer and Paolo Saccardo, offer an “tailored”[...] 12 Aug The U2 of NANBIOSIS, Custom Antibody Service (CAbS) has expanded its capabilities with two new equipment items an Automated microdispensing system for microarray technology and a Nitrogen Tank Cryomemo. The Automated microdispensing system for microarray technology is a sciFLEXARRAYER S3 is an automated piezo driven, non-contact dispensing system of ultra-low volumes specifically designed as an economical entry unit for academia and R&D labs. It consists of XYZ-stages with spindle drives, a piezo dispensing unit and precision equipment for liquid handling. The system handles volumes from 50 picoliters up to several microliters. The S3 is suitable for the production DNA, protein,[...] 10 Aug Researcher of CCMIJU published an article in the scientific journal FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY with the participation of NANBIOSIS Unit 14 of Cell Stem CellTherapy where culture and in vitro studies wereperformed, The researchers have shown that the regenerative potential and immunomodulatory capacity of cardiosphere-derived cells (CDCs) is mediated by paracrine mechanisms. In this process, extracellular vesicles derived from CDCs (EV-CDCs) are key mediators of their therapeutic effect. Considering the future applicability of these vesicles in human diseases, an accurate preclinical-to-clinical translation is needed, as well as an exhaustive molecular characterization of animal-derived therapeutic products. Based on that,[...] 31 Jul Researchers of NANBIOSIS -ICTS U9, Synthesis of Nanoparticles Unit, from CIBER-BBN andAragon Institute of Nanoscience (INA), have published an interesting study on the Scientific Jounal Materials of Fluid Dynamics and Chemical Parameters. The objective of the the work was to produce gastroresistant Eudragit (R) RS100 nanoparticles by a reproducible synthesis approach that ensured mono-disperse nanoparticles under the size of 100 nm. Batch and micromixing nanoprecipitation approaches were selected to produce the demanded nanoparticles, identifying the critical parameters affecting the synthesis process. To shed some light on the formulation of the targeted nanoparticles, the effects of particle size and homogeneity of fluid dynamics,[...] 26 Jul The Innovation Radar Platform is a European Commission initiative to identify high potential innovations and innovators in EU-funded research and innovation framework programmes based on their market readiness. Researchers of NANBIOSIS U8 Micro– Nano Technology Unit, led by Rosa Villa, contribute to the @InnoRadarEU with two innovations related to their research on graphene-based neuroprobes: Flexible neural probes for monitoring infraslow brain activity This innovation was developed under the Horizon 2020 project GrapheneCore2 by CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED (CIBER), FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA (ICN2) and AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS (CSIC) Multiplexed Neurosensor Arrays based[...] 23 Jul NANBIOSIS is organizing an on-line Conference on Nanotoxicity in collaboration with Nanomed Spain and Materplat, next September 22, to debate about the efect of nanotoxicity of nanoparticles and nanotechnologies in health. Nanotechnology, a science involved in the design, production, and use of structures and objects that have at least one of their dimensions on the scale of 100 nanometers or less, is enabling progress to be made in various areas with far-reaching repercussions. scope for society. Currently, there are several areas in which nanotechnology is under development or even in the practical application phase. However, manufactured nanoparticles can have very different properties and effects[...] 23 Jul This year, CCMIJU, partner of NANBIOSIS, at Cáceres, has organised some new hands-on and customised workshops with robotic technology, expected for 2020 last term. Specifically CCMIJU is organising, in collaboration with the Enterprise ABEX-Excelencia Robótica SL, some workshops on Robotic Surgery (da Vinci Xi) using experimental models. They are addressed to health professionals from several specialties (urology, gynaecology, general surgery and thoracic surgery) interested in practising with this technology. The workshops will count on a clinical specialist from ABEX, who will explain the technical features of the robotic equipment, the associated technologies and the virtual simulator for exercises. Subsequently the health professionals,[...] 22 Jul The Catalan Government announced yesterday the Narcís Monturiol Medal award for scientific and technological merit to the Director of NANBIOSIS Unit 7 Nanotechnology Unit from CIBER-BBN and IBEC, Josep Samitier Martí, for his contribution to the development of the Catalan system of science and technology. The Narcís Monturiol Prize was established by the Generalitat of Catalonia in 1982, in honor of the Catalan scientist and inventor Narciso Monturiol, to award the people and entities that have made an outstanding contribution to the scientific and technological progress of Catalonia. It is awarded in the form of medals and plaques. The medals[...] 16 Jul Researchers of NANBIOSIS U8 Micro– Nano Technology Unit of CIBER-BBN at the Barcelona Institute of Microelectronics have participated in the recent developments of a new graphene-based detection platform that could be the gateway to unlock superior understanding of the brain by providing a measure of high brain activity resolution and in real time. This research has been developed within the framework of the EU BrainCom project. The European Union’s Horizon 2020 research project, BrainCom, is coordinated by the ICN2 Advanced Electronic Materials and Devices Group led by Professor José A. Garrido and the CIBER BBN GBIO Group and the Nanbiosis[...] 15 Jul Researchers of NANBIOSIS U9 Synthesis of Nanoparticles Unit, of the CIBER-BBN at the University of Zaragoza, use thymol as a natural biocide, a component present in the essential oils of thyme and oregano, thus fighting against the predictions that in 2050 there will be more deaths from infections associated with antibiotic-resistant bacteria than from cancer. Some topical wounds caused by burns, by surgical procedures, diabetic foot ulcers, fistulas, pressure ulcers, etc. they can become infected and become chronic, rendering current treatments ineffective. Currently, the devitalized tissue is removed, the area is cleaned, it is drained and depending on the microbia[...] 13 Jul A new article has been recently published about Cardiac hypertrophy research in the Scientific Reports Jorunal by NatureResarch, counting with the expertise of NANBIOSIS unit 17 Confocal Microscopy Service form CIBER-BBN and University of Alcalá de Henares. Cardiac hypertrophy is the abnormal enlargement, or thickening, of the heart muscle, resulting from increases in cardiomyocyte size and changes in other heart muscle components, such as extracellular matrix. This article relates more especifically with the link between long term exposure to xenoestrogen Bisphenol-A and adverse cardiovascular effects and the role of necroptosis in cardiac response to BPA had not yet been explored.[...] 09 Jul Researchers from NANBIOSIS U18 Nanotoxicology Unit at the Institut d’Investigació Biomèdica de Sant Pau (IIB Sant Pau) and NANBIOSIS U1 Protein Production Platform (PPP) at the Universitat Autònoma de Barcelona (UAB) toghether with researchers of Institut de Recerca contra la Leucèmia Josep Carreras (IJC) have demonstrated the efficacy of a new nanoconjugate, designed in house, that blocks dissemination of leukemic cells in animal models of acute myeloid leukemia. These results have been published in a high impact scientific journal in the field of oncology and hematology, Journal of Hematology and Oncology. Most of the experimental work has been performed in[...] 03 Jul Researchers from NANBIOSIS U10 Drug Formulation unit (CIBERBBN – UPV/EHU led Rosa María Hernández, have developed a biomedical device consisting of by-products from the food industry and which displays excellent properties for use in regenerative medicine. The work has been published in the Green Chemistry Jurnal, one of the most prestigious international journals in chemistry and the second most important one in the field of sustainable science. The work has also been selected for the cover page of this issue. Researchers in the UPV/EHU’s NanoBioCel and Biomat groups have developed a biomedical device consisting of by-products from the food industry and which displays excellent[...] 29 Jun JUMISC has organised the Course on introcuction to research and laboratory techniques in biomedicine which wil take place during the month of July, co-Directed by Francisco M. Sanchez Margallo, Deputy Scientific Director of NANBIOSIS and Javier García Casado, Scientific Director of NANBIOSIS unit 14 Cell Therapy. Further information and programe: here Inscriptions: her[...] 25 Jun Manuel Doblaré researcher of the Group Applied Mechanics and Bioengineering – AMB and NANBIOSIS U13 Tissue & Scaffold Characterization Unit of CIBER-BBN and I3A presides, from this month, the Board of Trustees of the Imdea Materiales Foundation. The IMDEA Materials Institute, one of the seven Madrid Institutes for Advanced Studies (IMDEA), is a public research centre founded in 2007 by Madrid’s regional government. The goal of the Institute is to do research at the forefront of Material Science and Engineering, attracting talent from all around the globe, and collaborating with companies in an effort to transfer fundamental and applied knowledge into[...] 25 Jun The special program on the coronavirus pandemic by “En Ruta con la Ciencia” of Aragón Televisión, analyzes different aspects of the disease with special attention to the work of Aragonese scientists. Among them, two research groups that coordinate NANBIOSIS units 9 and 27. Starting at minute 44’45 ‘of the program, Doctor Jesús Lázaro, researcher of the BSICoS group of I3A-UZ and CIBER-BBN, led by Pablo Laguna, which coordinates NANBIOSIS U27 High Performance Computing Unit, explains his research. For almost 3 years, Jesús Lázaro had been working on a European project to develop a respiratory and heart rate monitoring system for[...] 23 Jun Jesús Morón-López (IMDEA), Serena Molina (Chemical Engineering Department, University of Alcalá) have recently published the results of their research about Recycled-Membrane Biofilm Reactor as a sustainable biological treatment for microcystins (MC) removal. The study addresses the lack of sustainable technologies for water treatment, while opening an alternative in sustainable solid waste management under a circular economy approach. The biofilm visualization has been performed by ICTS “NANBIOSIS”, more specifically by the Unit 17 Confocal Microscopy Service of Ciber in Bioengineering, Biomaterials & Nanomedicine (CIBER-BNN) at the Alcala University (CAI Medicine Biology) led by Juan Manuel Bellón y Gemma Pascual. In this[...] 21 Jun The European Commission Representation in Barcelona has published the five-minute video “The EU fights the Covid-19 from Catalonia” in which four researchers explain the projects they are working on. The researchers appearing in the video are Laura Lechuga Scientific Director of NANBIOSIS unit 4 from CIBER-BBN and ICN2-CSIC and Group Leader of CIBER-BBN at the ICN2 Nanobiosensors and Bioanalytical Applications Group), who works on a sensor to detect the coronavirus in a faster, easier and cheaper way than with current PCRs, Núria Montserrat (IBEC), who works on micro-kidneys made from stem cells to test a drug able to block the virus, Alfonso Valencia (BSC), who explains[...] 17 Jun Researchers of NANBIOSIS Unit 17 Confocal Microscopy Service have participated in the research carried out structuring hydrophobic domains in Poly(N-isopropylacrylamide-co-Methacrylic acid) hydrogels for biomedical aplplications. Hydrogels are cross-linked polymeric networks, which have the ability to hold a large amount of water in their structure. Hydrogels can be designed to respond to a specific stimulus such as temperature, pH, ionic strength, light, etc., making making them suitable for biomedical applications, as drug delivery. The most popular responsive polymeric hydrogel is made of poly(N-isopropylacrylamide) (PNIPAM). The copolymerization of NIPAM with an acrylic/methacrylic acid monomer permits the development of a hydrogel with a[...] 12 Jun Last June 8, 2020, Ramón Martínez Máñez, Scientific Director of CIBER-BBN and NANBIOSIS U26, gave an on line seminar, hosted by Jaume Veciana and Anna Roig will from ICMAB-CSIC on Molecular probes and gated materials in biomedical applications and communication between nanoparticles. If you missed the seminar, you can see it now on YouTube: More information at the ICMAB website.[...] 08 Jun The 15th edition of the Webometrics Ranking of World Universities has been published, ranking researchers in Spain as well as Spaniards doing research abroad. A total of 11 Directors of NANBIOSIS units appear on the most recent list, featured on the top 2000. The list is ordered by the h-index, a metric that calculates research impact based on a correlation of papers published and number of citations, and then by number of citations. The result is a list of whose’s publications have had more impact online. NANBIOSIS researchers featured are Fernando Albericio (#207), scientific director of U3 Synthesis of Peptides[...] 04 Jun Ana Paula Candiota, Scientific Coordinator of NANBIOSIS U25 NMR: Biomedical Applications I Unit (from CIBER-BBN and Autonomous University of Barcelona), is the Guest Editor of a special issue launched by MDPI in the International Journal of Molecular Sciences (IF 4.183). This special issue is about “In Vivo Biomarkers for Immunotherapy Efficacy in Brain Tumours” Contributions with papers or reviews to this issue, can be fowarded to the Guest Editor (AnaPaula.Candiota@uab.cat) with a tentative title and/or abstract. Final deadline for submission: 31/10/2020[...] 03 Jun The International Meeting for Chemistry Expoquimia is hosting the INDUSTRIAL DIALOGUES Webinars, a total of 4 seminars discussing different topics related to the cores of the triennial meeting: circular economy, digitalization, and technology transference. This last topic will be covered by Nora Ventosa, Scientific Coordinator of NANBIOIS Unit 6Biomaterial Processing and Nanostructuring Unit On 4 June, Nora Ventosa, Nora Ventosa will be moderating the round table on the topic of technology transference both as a researcher of the Nanomol group, from CIBER-BBN and ICMAB-CSIC, and as part of the Expoquimia Organizing Comitée. The discussion will be focused on the topic “Creating tools to make innovation a reality. Science and[...] 02 Jun Researchers of BSICoS Group form CIBER-BBN and I3A-Unizar, coordinating NANBIOSIS Unit 27 tooghether with researchers of Physense group of UPF and Hospital Clinic have carried out the research which results have been just published by Journal of Interventional Cardiology. The researchers propose automatic analysis of EGM signals using the “Slow Conducting Channel Mapping Algorithm” that improves the accuracy of bipolar voltage measurements within the scar area, achieving a more detailed tissue characterization and being an operator-independent tool for accurate identification of SCCs. This last feature encourages the use of the algorithm together with EAM navigation systems as a reproducible approac[...] 01 Jun CSIC has orgnized an interactive webinar on new COVID-19 detection systems that brings together biotechnologist Luis Blanco, nanotechnologists Laura Lechuga and Pilar Marco, and physicist Javier Tamayo . Researchers from the Higher Council for Scientific Research (CSIC) will answer citizens’ questions about the diagnostic methods of the SARS-CoV-2 coronavirus, which causes Covid-19, in a webinar or interactive debate that will be broadcast on Wednesday, June 3, at 8:15 p.m., on the CSIC YouTube channel. The meeting will feature the participation of biotechnologist Luis Blanco, the physicist Javier Tamayo and the nanotechnologists Laura Lechuga, Scientific Director of NANBIOSIS unti 4 Biodeposition[...] 28 May A new nanomaterial for bioimaging has been developed by researchers at NANBIOSIS Unit 6 Biomaterial Processing and Nanostructuring Unit from the Nanomol group from ICMAB-CSIC and CIBER-BBN . The researchars are also members of the TECNIO technology transfer network ACCIÓ-Generalitat de Catalunya, together with the New Jersey Institute of Technology (NJIT, USA) and the University of Parma (UNIPR, Italy). The results of the study are the result of the TECNIOspring PLUS project co-financed by ACCIÓ and the European Commission. It is true that it is very difficult to understand what happens in our bodies if we are unable to visualise it. For example, we currently know that tumour cells[...] 27 May Osteoporosis is an illness which appears when the osteoblast/osteoclast activities are unbalanced taking place bone resorption (caused by osteoclasts) in higher extension than bone formation (induced by osteoblasts). Alendronate is one of the most used drugs for osteoporosis treatment despite its scarce bioavailability. In an attempt to improve it, gated mesoporous silica nanoparticles, for the controlled release of alendronate, have been synthesized and characterized. These hybrid nanoparticles include labelled alendronate inside the porous, those porous are capped with a peptide designed to be selectively cleaved by cathepsin K enzyme (overexpressed in osteoclasts). Two CIBER-BBN units of the ICTS NANBIOSIS wer[...] 25 May NANBIOSIS Protein Production Platform (PPP) Unit 1 (of CIBER-BBN and Autonomous University of Barcelona) is involved in a micro-patronage project for the development of a vaccine for COVID 19. NANBIOSIS Unit 1 is directly involved in the initial part of the Virus Like Particles and Proteins expression and purification project of SARS-COV-2 Most vaccines used today are based on either attenuated forms of the original pathogen, or are inactivated vaccines, in which the pathogen has undergone physical or chemical treatments to eliminate its infectivity. The project proposes to use a new vaccine strategy based on recombinant proteins in imitation of[...] 25 May The Journal Heraldo de Aragón has published an article highlighting the participation of Aragonese researchers in projects to fight Covid-19 Pandemic. Pilar Martín Duque, researcher from NANBIOSIS U9 Synthesis of Nanoparticles Unit, is leading a project financed by the Covid-19 Fund, launched by the Carlos III Health Institute (ISCIII). Thanks to this project, rapid and early diagnostic tests of Covid-19 are being developed to reduce false negatives. To read the article: https://www.heraldo.es/branded/la-tecnologia-y-la-innovacion-claves-vitales-para-el-desarrollo-sostenible/[...] 25 May The Jorunal “Redacción Médica” has created an espace call Covid-19 Lessons to gather critical evaluations and recommendations of the most relevant personalities in the health sector, so that the National Health System and the professional and business ecosystem that surrounds it can draw conclusions and face future similar challenges with greater guarantees. Laura M. Lechuga, Scientific Director of NANBIOSIS U4, from CIBER-BBN at ICN2-CSIC, coordinates CONVAT, one of the projects selected by the European Commission to advance in the knowledge about the Coronavirus, adds her perspective to the document Covid-19 Lessons: “We need a drastic change in the organization and[...] 23 May Researchers CIBER-BBN and NANBIOSIS Unit 26, the Príncipe Felipe Research Center (CIPF), the Universitat Politècnica de València (UPV) and the Institut de Recerca Biomèdica (IRB) of Barcelona manage to inhibit tumor growth, reduce metastasis and decrease the toxicity of the antitumor drug Navitoclax in preclinical animal models of triple negative breast cancer (TNBC). These types of TNBC tumors do not express any of the three receptors involved in most breast cancers (estrogen, progesterone, and HER2), so the most common treatments such as hormone therapy are not viable in these patients. This new study, led by Mar Orzáez, principal investigator of[...] 22 May Within the series of virtual conferences organized during the months of May, June and July by the Extremaduran office, two researchers of NANBIOSIS are invited speakers: Laura M. Lechuga Gómez, NANBIOSIS Unit 4 Biodeposition and Biodetection Unit (form CIBER-BBN and ICN2-CSIC); and María Coronada Fernández Calderón NANBIOSIS U16 Surface Characterization and Calorimetry Unit (from CIBER-BBN and University of Extremadura)who will talk about technologies at the service of health. The cycle ’90 minutes for Science, for innovation to bring society closer to the latest scientific trends, starts next Wednesday, May 27, at 5:00 p.m. It will deal with topics such as[...] 20 May The work carried out by the team of researchers of CIBER-BBN and Politecnic University of Valencia, led by, Ramón Martínez Máñez, Scientific Director of NANBIOSIS U26 NMR: Biomedical Applications II, is highlighted by the Spanish TV. This team has developed a new drug against lung cancer that, along with other therapies, eliminates cells that have been bottled prematurely without harming healthy ones. The drug has been successfully administered in mice, now it comes the challenge of finding a way to administer it without damaging the patient’s healthy organs, and they propose inserting it into a capsule that would be released[...] 17 May Next June 8, 2020, 12 pm, Ramón Martínez Máñez, Scientific Director of CIBER-BBN and NANBIOSIS U26, give an on line seminar, hosted by Jaume Veciana and Anna Roig will from ICMAB-CSIC. The development of optical molecular probes and probes based on gated nanoparticles has been an area of interest during the last decades. Optical probes are able to transform chemical information in the environment into a suitable optical signal, usually a change in colour of fluorescence. Moreover, gated materials have also been widely used for the development of drug delivery systems. Some examples of optical probes and gated materials for[...] 15 May Prof. Laura M. Lechuga, Scientific Director of NANBIOSIS Unit 4 Biodeposition and Biodetection Unit (from CIBER-BBN and ICN2-CSCIC) was awarded with the Physics, Innovation and Technology Award of the Royal Spanish Physics Society (RSEF) and the BBVA Foundation 2016. BBVA Foundation has dedicated an article to explain the EU CoNVaT project, led by Laura Lechuga, whose objective is to obtain a diagnostic test for COVID-19 from the first day of infection, fast but highly sensitive, and which does not require a laboratory or qualified personnel. A test made with extremely sophisticated technology, and at the same time low cost, applicable to[...] 11 May Researchers of NANBIOSIS-ICTS Units from CIBER-BBN: U1 Protein Production Platform (PPP) at IBB-UAB, led by Antoni Villaverde and Unit 18 Nanotoxicology Unit at IBB-Hospital Sant Pau, led by Ramón Mangues, have demonstrated a potent T22-PE24-H6 antineoplastic effect, especially in blocking dissemination in a CXCR4+ DLBCL model without associated toxicity. Thereby, T22-PE24-H6 promises to become an effective alternative to treat CXCR4+ disseminated refractory or relapsed DLBCL patients. Diffuse large B-cell lymphoma (DLBCL) is a cancer of B cells, a type of lymphocyte that is responsible for producing antibodies. It is the most common form of non-Hodgkin lymphoma among adults, with an annual incidence of 7–8 cases per 100,000 people per year in the US and[...] 10 May David Sampedro and Esther Pueyo, from NANBIOSIS Unit 27 High Performance Computing (CIBER-BBN, I3A-UZ) have conducted a research about Neurocardiac Oscillation in Repolarization and Cardiac Arrhythmias. Recent studies in humans and dogs have shown that ventricular repolarization exhibits a low-frequency (LF) oscillatory pattern following enhanced sympathetic activity, which has been related to arrhythmic risk. The appearance of LF oscillations in ventricular repolarization is, however, not immediate, but it may take up to some minutes. This study seeks to characterize the time course of the action potential (AP) duration (APD) oscillatory behavior in response to sympathetic provocations, unveil its underlying mechanisms[...] 08 May The Fourth Vice-President of the Government and Minister for the Ecological Transition and the Demographic Challenge, Teresa Ribera, and the Minister of Science and Innovation, Pedro Duque, met with the Multidisciplinary Working Group that advises and supports the Ministry of Science and Innovation in scientific matters related to the COVID-19 and its future consequences. It also coordinates the preparation of reports and will propose the necessary modifications to improve the response to similar crises in the future. The group is formed by 16 experts in fields such as law, economy, biochemistry, bioinformatics, artificial intelligence, physics, statistics, immunology or medicine. Prof. Laura Lechuga, Scientific[...] 06 May The Institute of Health Carlos III (ISCIII), depending of the the Ministry of Science and Innovation, has validated thirty new centers for carrying out PCR tests for COVID-19 infections throughout Spain. The Minimally Invasive Surgery Center, together with the University of Extremadura (JUMISC), partner of NANBIOSIS, will carry out these PCR tests in the laboratory of the veterinary faculty of Cáceres, as it is a P2 biosafety laboratory that is already approved. They will have the capacity to perform 200 daily PCRs and will work with the samples that the the Extremadura Health Service will send them. In total, Spain[...] 05 May Scientists of NANBIOSIS unit 26 NMR: Biomedical Applications II, (of CIBER-BBN and the Universitat Politècnica de València), together with researchers from the Principe Felipe Research Center and the University of Cambridge confirm the therapeutic potential of using a new conjugated drug, Nav-Gal, in combination with chemotherapy Nav-Gal selectively removes tumourigenic senescent cells without attacking healthy cells and reduces the toxicity of platelets The accumulation of senescent cells plays a significant role in cancer pathogenesis and other diseases. However, senolytic drugs (intended to remove senescent cells) present significant toxicity, which limits their therapeutic benefits. Now, a new international study involving researchers[...] 03 May M.-Pilar Marco, Scientific Director of NANBIOSIS Unit 2 Custom Antibody Service (CAbS) has been interviewed on Spanish TV (RTVE) to talk about her research against the Covid-19 pandemic in the frame of the CSIC POC4CoV project, for the development of new and rapid diagnostic tools. Nb4D group of CIBER-BBN and IQAC-CSIC, led by Prof. Marco is working on the development of tests to increase the efficiency and speed of diagnosis of the methods currently on the market. According to Pilar Marco, the new strategy of the project differs basically in two fundamental aspects: on the one hand the technology, whic[...] 30 Apr Nora Ventosa and Nathaly Segovia, (Scientific Director and Coordinator of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit from CIBER-BBN and ICMAB_CSIC), have been selected as part of the NARTIC Project team for an incubation program by Barcelona Activa. NARTIC is a biotech project for the development of molecular therapy based on Quatsomes for diseases such as cancer. The NARTIC project has recently been selected for the 6th edition of the Preacceleration Program, an incubation program developed by Barcelona Activa for starting ventures with a high technological impact. The project team includes two researchers from the Molecular Nanoscience and Organic Materials (NANOMOL) group (from CIBER-BBN and ICMAB-CSIC): Nora Ventosa, as scientific advisor, and Nathaly Segovia, as[...] 28 Apr Researchers of NANBIOSIS Units at JUMISC. led by Verónica Crisóstomo, Scientific Director of NANBIOSIS unit 24 of Medical Imaging, have just published an article in the Journal Scientific Report Cardiovascular diseases, especially ischemic heart disease, are the leading cause of mortality worldwide. Conventional treatments have contributed to reduce early mortality after an acute myocardial infarction, but do not recover the damaged myocardial tissue. In the last two decades stem cell therapy has been studied for that purpose. Nowadays it is known now that stem cells are able to secrete combinations of biomolecules that modulate the composition of the damaged cardiac[...] 26 Apr Researchers of NANBIOSIS U12. Nanostructured liquid characterization unit from CIBER-BBN and IQAC-CSIC have recently published an interesting review entitled “A Concise Review on Nano-emulsion Formation by the Phase Inversion Composition (PIC) Method” in the JOURNAL OF SURFACTANTS AND DETERGENTS. https://doi.org/10.1002/jsde.12414 Studies of phase behavior and particle sizing were performed at the Nanostructured Liquid Characterization Unit, member of the NANBIOSIS ICTS.[...] 23 Apr Bsicos group researchers, from the I3A (Engineering Research Institute) of the University of Zaragoza and CIBER-BBN), Dr. Jesús Lázaro, Dr. Eduardo Gil, Dr. Raquel Bailón and Dr. Pablo Laguna, are working on a line of work for the search of solutions for the early diagnosis of Covid-19 cases, through the development of an App for mobile phones. For almost three years, Dr. Jesús Lázaro, under the supervision of Professor Pablo Laguna, from the resarch group Bsicos, which coordinate Nanbiosis U27 High Performance Computing , have been working on the European project WECARMON (Wearable Cardiorespiratory Monitor) for the development of an[...] 22 Apr Researchers Dr. Jesús Lázaro and Dr. Pablo Laguna, from Bsicos group, which coordinate Nanbiosis U27 High Performance Computing from I3A -Engineering Research Institute of the University of Zaragoza- and CIBER-BBN, in the framework of the European project WECARMON (Wearable Cardiorespiratory Monitor) are coauthors of the recently published article titeled “Wearable Armband Device for Daily Life Electrocardiogram Monitoring” in the Scientific Journal IEEE Transactions on Biomedical Engineering ( Early Access ) “Our long-term wearable armband is evaluated as heart rate monitor with 24h recordings during daily life”, explained Dr. Jesús Lázaro. A wearable armband electrocardiogram (ECG) monitor has been used for daily life monitoring. T[...] 20 Apr Next 6 of May wii take place the On-line Conference Biosensors for Pandemics: Reliable and efficient nanotech-based diagnostics in emergency situations, will gather worldwide well known experts in biosensing technologies currently working in COVID-19 diagnostics or having very relevant technologies in the field. Prof. Laura Lechuga, Scientific Director of NANBIOSIS U4 Biodeposition and Biodetection Unit of CIBER-BBN and ICN2-CSIC, will be one of the speakers. Laura Lechuga is coordinating the European proyect CONVAT: advanced nanobiosensing platforms for point-of-care diagnostics and surveillance of coronavirus for rapid diagnosis and monitoring of COVID ー 19, To join Deadlines: Abstract Submission (ePoster request): April 22,[...] 19 Apr The Jesús Usón Minimally Invasive Surgery Center (CCMIJU), partner of NANBIOSIS, has been granted the with the FID-CPI Innovative Public Procurement Program of the Ministry of Science and Innovation, as well as with the support of the Ministry of Economy, Science and Digital Agenda of the Board, for the development of the TREMIRS project “Minimally invasive robotic surgery systems” aimed at improve current techniques in laparoscopy and microsurgery TREMIRS will improve current robotic surgical systems, providing better service to the patient, better ergonomics to the surgeon and greater benefits to the surgical team, achieving an increase in the quality of[...] 17 Apr NANBIOSIS U9 Synthesis of Nanoparticles Unit has participated in a research carried out bu researchers of CIBER-BBN group FIOBI-HULP at Hospital de la Paz, led by Nuria Vilaboa. reclently published in the scientific journal Biomaterials The researchers have used transgenic cells, which are incorporated into the scaffolding, to regulate the physiological production of bone growth factors and induce the osteoinduction process. Achievement of spatiotemporal control of growth factors production remains a main goal in tissue engineering. In the present work, we combined inducible transgene expression and near infrared (NIR)-responsive hydrogels technologies to develop a therapeutic platform for bone regeneration. A[...] 16 Apr Researchers of NANBIOSIS U3 Synthesis of Peptides Unit of CIBER-BBN at IQAC-CSIC, led by Miriam Royo, have published an article in the scientific journal ACS Omega that develops a method for the production of cholesterol conjugates to peptide ligands through polyethylene glycol (ND-PEG) not dispersed through a non-hydrolyzable bond. The developed methodology allows to generate stable, highly pure and well defined Chol-PEG compounds, linked to different lengths of PEG from 4 to 20 units of ethylene oxide through an ether bond. These Chol-PEG compounds were conjugated with different peptides, such as cyclic peptide (RGDfK), gluturation and a Tf1R peptide ligand,[...] 15 Apr In response to the COVID-19 pandemic, several research infrastructures (RIs) NANBIOSIS among them, have set up specific services, such as rapid or fast track access, to allow researchers to obtain results as soon as possible. The Association of European-Level Research Infrastructures Facilities (ERF-AISBL), collects the relevant information about the initiatives on a dedicated website. NANBIOSIS provides rapid access for COVID-19 research. The ICTS offers preclinical stages services of biomedical product development, specifically, synthesis and preparation of biomolecules like antibodies, peptides, recombinant proteins, oligonucleotides for diagnostic therapeutic and prophylactic purposes.[...] 14 Apr Rosa Villa Sanz, the Scientific Director of NANBIOSIS U8 Micro– Nano Technology Unit was appointed group leader the CIBER during the last meeting of the Permanent Commission of CIBER-BBN, replacing Prof. Jordi Aguiló. Rosa Villa Sanz, graduated in Medicine from the University of Barcelona and has a doctorate from the Autonomous University of Barcelona in 1993 and a specialist in Nuclear Medicine (MIR-Hospital de Bellvitge-Barcelona), is a scientific researcher at the CSIC and leader of the Biomedical Applications Group of the Barcelona Institute of Microelectronics (CSIC), whose main research interests are the design and manufacture of Micro and Nano Systems[...] 13 Apr Prof. Laura Lechuga, Scientific Director of NANBIOSIS U4 Biodeposition and Biodetection Unit of CIBER-BBN and ICN2-CSIC, who is coordinating the European proyect CONVAT for rapid diagnosis and monitoring of COVID ー 19, will be one of the speakers at the webinar organized next tuesday, 16 by the Young Academy of Spain, (JAE) about How Spanish science is contributing to the fight against COVID-19. The talk by Prof Lechuga is titled “COVIDー 19 diagnosis: advantages and limitations of different techniques” Global Young Academy (GYA) was created in 2010 at the initiative of young scientists and researchers from around the world who[...] 09 Apr The Spanish Higher Council for Scientific Research (CSIC) will finance the project Point-of-care tests for the rapid detection of SARS-CoV-2 (POC4CoV), whose objective is to have effective diagnostic technologies for Covid-19. The Institute of Microelectronics of Barcelona (IMB-CNM-CSIC), the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC) and the Institute of Materials Science of Aragon (ICMA) participate in it. The POC4CoV project aims to develop Point-of-Care (POC) devices for the in vitro diagnosis of SARS-COV-2 infection quickly and reliably, thanks to the use of multiplexed systems and the use of particular biomolecular probes. To do this, POC technological platforms will b[...] 07 Apr The Malaga Academy of Sciences has published an interesting review by Dr. José Becerra Ratia on Spanish biomedical research in relation to COVID-19 virus and, in particular, with two therapeutic novelties that have stem cells as protagonists, in one case the mesenchymal cells and in the other case the embryonic ones. Professor Becerra is Professor of Cellular Biology at the University of Malaga and Vice President of the Malaga Academy of Sciences, as well as Researcher in charge of the Bioengineering and Tissue Regeneration Laboratory that belongs to BIONAND, IBIMA CIBER-BBN and TerCel (unit 28 of NANBIOSIS U28 Nanoimaging Unit)[...] 06 Apr Due to the current pandemic outbreak of COVID-19, caused by the SARS-CoV-2 virus, knowledge about the virus characteristics and the development of its possible diagnostic, treatment and prophylactic devices and systems are high priority in all research institutions worldwide. NANBIOSIS assigns high priority to the projects related to the SARS-CoV-2 virus offering preferential access. Some of the NANBIOSIS’s services have been suspended or postponed. However the call is open and the proposals will be processed and services required will be provided as soon as possible. For that purpose, A “COVID-19 Rapid Access” call has been established, valid through the year 2020. Urgent procedure will be applied[...] 01 Apr Researchers of NANBIOSIS U9 Synthesis of Nanoparticles Unit, present the first successful synthesis of monodisperse carbon nanodots (CNDs) with tunable photoluminescence (PL) carried out by laser pyrolysis of two common volatile organic precursors such as toluene and pyridine. Remarkably, the initial chemical composition of the precursor determines the formation of undoped or N-doped CNDs and their corresponding absorption response in the visible range (expanded for the latter). Researchers have demonstrated the control and versatility of this synthesis method to tune the final outcome and its potential to explore a great number of potential solvent candidates. Furthermore, they have successfully exploited[...] 25 Mar Heraldo de Aragón publishes today an opinion article written by Jesús Santamaría, Scientific Director of Nanbiosis U9 Synthesis of Nanoparticles Unit about the COVID19 Pandemic in the relation with the investment in R&D. The proffesor at the University of Zaragoza makes a quick review on the the main milestones reached by researchers to fight the COVID 19: “In early December some Wuhan residents start to get sick after visiting a local market, with what looked like flu symptoms. Nevertheless, Chinese health officials report to World Health Organization on New Year’s Eve that a group of patients presented a new ty[...] 24 Mar On March 10-12 a two-day meeting between representatives of NANBIOSIS units, took place at the Jesús Usón Minimum Invasive Surgery Center (CCMIJU), in Cáceres, to plan the work to be done in the coming months and carry out some tests within the framework of the European project Safe-N-MedTech. Several units of the ICTS NANBIOSIS will carry out some of the F/Q, in vivo and in vitro characterizations applied to the test cases of the project. NANBIOSIS is actively involved and works in close collaboration with the four Test Case Developers: Stryker, RCL, HELIA Biomonitoring and TECNAN. Additionally, NANBIOSIS is t[...] 20 Mar The PhD Researcher Dolores Bueno researcher of NANOMOL Group and NANBIOSIS Unit 6 Biomaterial Processing and Nanostructuring Unit (from CIBER-BBN and ICMAB-SCIC) has defended her PhD thesis today, 20 March 2020, by videoconference from the ICMAB Meeting Room. No public was allowed due to the drastic measures of containment taken to tackle COVID-19. Peptide functionalized nanoliposomes for biomolecule intracellular delivery, prepared using compressed CO2 Abstract: Fabry disease is a rare disease caused by a gene mutation on the X-chromosome, which encodes α-galactosidase A (GLA) enzyme. The lack of GLA causes the accumulation of globotriaosylceramide at the lysosomes. The actual treatment is[...] 19 Mar The Spanish Official State Bolletin of March 18, 2020 published the Royal Decree-Law establishing measures to support research on COVID-19, including the authorization of an extraordinary credit for direct grants for research projects and programs of the COVID-19.The Carlos III Heath Institute (ISCIII) calls for the presentation of expressions of interest to promote knowledge about SARS-CoV-2 and the CoVid disease19, as well as its impact on infected people. The aim of the proposals shall be to contribute to an efficient treatment of patient and / or public health rresponse. Proposals must be appropriate to the emergency situation and, therefore, allow[...] 17 Mar Pedro Sánchez, the Spanish President has announced today the decision of the Council of Ministers to allocate 30 million euro for the research of the SARS-CoV2 coronavirus vaccine. This budget item will go to the Higher Center for Scientific Research (CSIC), State Agency for Scientific Research and Technological Development, and the Carlos III Health Institute (ISCIII), dependent on the Ministry of Science and Innovation. Specifically, 25.2 million euro will go to the ISCIII, of this amount, 24 million will directly finance research projects and programs for the new coronavirus. The ISCIII, as a research funding agency in the health field,[...] 14 Mar Prof. Laura M. Lechuga, Scientific Director of NANBIOSIS Unit 4 Biodeposition and Biodetection Unit (from CIBER-BBN and ICN2-CSCIC) has been today interview by Cadena Ser Radio in the program “Hoy por Hoy” The interview can be listened in the following podcast, begining at 44 minute. ‘Convat’ is a nanotechnological device with biosensors capable of determining in less than half an hour the presence of coronavirus in a person. A sample saliva is deposited on a nanochip three centimeters long. If the saliva contains the virus, it will bind to antibodies located on the nanochip. A beam of light will be passed[...] 12 Mar In order speed up research into the coronavirus, the European Commission recently announced a special call for projects to tackle the COVID-19, based on already developed technologies. Projectcs were prepared in a record time and 17 proposals have been awarded founds, 6 of them with spanish colaboration and only one coordinated by Spain CONVAT is a cooperation project between Spain, Italy and France coordinated by Prof. Laura M. Lechuga, Scientific Director of NANBIOSIS Unit 4 Biodeposition and Biodetection Unit (from CIBER-BBN and ICN2-CSCIC) and also participated by the group of Prof. Jordi Serra Cobo from the University of Barcelona, having extensive experienc[...] 01 Mar The journal Chemistry. A European Journal features in its COVER the recently published article “An enantiopure propeller‐like trityl‐brominated radical: Bringing together a high racemization barrier and an efficient circularly polarized luminescent magnetic emitter” authored by rearserchers of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit, led by Jaume Veciana (CIBER-BBN, ICMAB-CSIC) Nowadays, it is necessary to know the increasingly specific requirements of electronic devices in order ot be able to find new multifunctional materials that allow obtaining more efficient devices. This article represents a step forward in the field of organic free radicals. Organic free radicals act as polarized light emitters synthesizing and[...] 27 Feb 29 of February is a ‘rare’ date and February, a month with a ‘rare’ number of days, has become a month to raise awareness about rare diseases and their impact on patients’ lives. Since 2008 thousands of events happen every year all around the world and around the last day of February. NanoMed Spain Platform and the Hospital of Sant Joan de Déu have organized the NanoRareDiseaseDay to present the latest innovations in the field of Nanomedicine for the treatment and diagnosis of rare diseases (diseases affecting less than 5 people per 10,000 inhabitants). Nora Ventosa, Scientific Director of NANBIOSIS U6 Biomaterial Processing[...] 25 Feb JUMISC and the Spanish Association of Coloproctocology has organised the ICourse on Coloretal Endoscopy for Surgeons which wil take place at JUMISC on March, 9 -10, co-Directed by Fernando de la Portilla de Juan (President of Spanish Association of Coloproctology) and Francisco M. Sanchez Margallo (Deputy Scientific Director of NANBIOSIS) The course includes colonoscopy practices in pig and canine models. For further information and inscriptions: her[...] 24 Feb Rare Disease Day is annually held on the last day of February in more than 100 countries with the main objective of raising awareness about rare diseases and their impact on the life of patients to the general public and in particular to policy makers, public authorities, industry representatives, researchers and professionals. Rare diseases are those that affect less than 1 in 2000 people. There are more than 300 million people living with one or more than more than 6000 rare diseases worldwide identified. Among the events organized we wont to mention the Nano Rare Diseases Day held in Barcelona[...] 23 Feb The Center for Industrial Technological Development (CDTI) has selected the proposal presented by JUMISC, partner of NANBIOSIS, on the technological challenge of an alternative cold preservation system in a preliminary market consultation.On February 4, the Technical Conference of the Preliminary Market Consultation of the Organ Preservation Challenge was held.The objective of the Preliminary Market Consultation was to obtain information from the market operators in the Organ Preservation technologies in order to adequately define the future potential for pre-commercial Public procurement and adequately inform the economic operators of the requirements that will be required in the Potential future tender for pre-commercia[...] 17 Feb Organ-on-chip (OOC) is the term used to define a microfluidic 3D culture model that contains continuously perfused chambers inhabited by living cells. OOC are considered as very promising tools for investigating many aspects of human physiology and pathophysiology as well as drug testing platforms with future progressions to be used for precision medicine. As the complexity of OOC systems increases, the necessity to integrate relevant assessment methods to provide information about cell physiology, secreted metabolites as well as pharmacodynamics drug responses also increases. Dr. Rosa Villa, who leads NANBIOSIS U8 Nano Technology Unit and the Biomedical Applications Group of t[...] 14 Feb Transfiere, the European Forum for Science, Technology and Innovation, the bigest professional and multisectoral forum for the transfer of knowledge and technology held in Spain, took place last February 12 and 13 in Malaga in its 9th edition. Among the events held at Transfiere, there has been a round table organized by all health-related platforms under the title: Challenges in precision medicine on the 12th at 6pm. Maria Luisa García Martín, Scientific Director of NANBIOSIS U28 of Nanoimaging Unit and head of Nano-Imagen facilities at BIONAND, was invited by the Nanomedicine platform, NanomedSpain as a speaker at the aforementioned round[...] 13 Feb NANBIOSIS has been informed about a recent publication in the pretigious scientific magzine SCIENTIFIC REPORTS (Q1) of Nature Research group, mentioning NANBIOSIS Unit 17 in the Methods section: Immunofluorescence analysis: Detection was performed by using a Leica SP5 confocal microscope (Leica Microsystems, Wetzlar, Germany), through the Confocal Microscopy Service of the ICTS ‘NANBIOSIS’ Unit 17 of the Biomedical Research Networking Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) at the University of Alcalá, Madrid, Spain. HIF-1α-dependent immunofluorescence intensity was quantified after digital capture using image-J software. The Leica TCS-SP5 confocal microscope with especial features allows studying interactions between cells/tissues and materials.[...] 12 Feb CCMIJU has organised the VII Course of Microscopic and Piezoelectric Techniques in Dentistry: Endodontics, Implantology and Prosthetics, which wil take place at JUMISC from March 3 till June 27 2020 under the Direction of Alberto Anta Escudero. (Profesor of the UPV-EHU), Gorka Santamaría Arrieta (Professor of the UPV-EHU), Jon Eskurza Pérez (Endodontics Specialist. Private Clinic) and Francisco Miguel Sánchez Margallo (Deputy Scientific Director of NANBIOSIS) The general objective of the course is the knowledge of the enodontology magnification, necessary materials and instruments and related ergonomic aspects. Training in magnification in dentistry Frurther information: Programm and inscriptions[...] 11 Feb In order to achieve full and equitable access and participation in science for women and girls, and also to achieve gender equality and the empowerment of women and girls, the United Nations General Assembly decided to proclaim in 2016 (resolution A / RES / 70/212) February 11 as the International Day of Women and Girls in Science. We want to take this day to congratulate all the women who lead research and innovation and contribute to the breakdown of the barriers that still exist, especially to the scientists from NANBIOSIS ICTS. Happy International Day of Women and Girls in Science![...] 10 Feb Researchers of two CIBER-BBN Units of the ICTS NANBIOSIS U18 Nanotoxicology Unit at Hospital Sant Pau. and U1, Protein Production Platform (PPP), at the Institute of Biotechnology and biomedicine of the Autonomous University of Barcelona (IBB–UAB), led by Prof Ramón Mangues, have developed a new drug that selectively removes metastatic stem cells, inducing a powerful metastasis prevention effect. Besides the participation of the “NANBIOSIS” ICTS Units U1 Protein Production Platform where Protein production was partially performed and U18 Nantoxicology Unit where Biodistribution studies were performed, all in vivo experiments were performed by the Unit 20 In Vivo Experimental Platform of CIBER[...] 07 Feb Researchers of NANBIOSIS U12 Nanostructured liquid characterization unit and U29 Oligonucleotide Synthesis Platform (OSP) of CIBER-BBN at IQAC-CSIC have obtained successfully ethylcellulose nanoparticles with positive zeta potential formed from nano-emulsion complexation with an antisense oligonucleotide which result very promising complexes for “in vitro” cell transfection. A new non-viral gene delivery vector has been developed, based on ethylcellulose, an easily available and low cost carbohydrate polymer, “generally recognized as safe” by the FDA. Although ethylcellulose is nonionic, positively charged nanoparticle dispersions have been obtained using nano-emulsion templates in cationic:non-ionic surfactant-based systems. The nanoparticles have been successfully complexed with negatively charged phosphorothioate antisens[...] 04 Feb Twenty years ago, the 4 February was declared World Cancer Day with the global challenge of cancer would not be forgotten. Since then, huge progress has been made to understand, prevent, diagnose, and treat cancer. NANBIOSIS as an ICTS (Singular Scientific and Technical infrastructures) for biomedical research plays a very important role in the fight against cancer. Some examples of the work carried out during the last year, are bellow: Unit 20 of NANBIOSIS at VHIR, works in several proyects reletaed to cancer as H2020-NoCanTher: magnetic nanoparticles against pancreatic cancer through the use of hyperthermia combined with conventional treatment. H2020-Target-4-Cancer: nanotherapy based on polymeric micelles directed against[...] 30 Jan The Center for Minimally Invasive Surgery (JUMISC), partner of NANBIOSIS, as the main beneficiary of the Spain-Portugal EUROAGE cross-border cooperation project that promotes active aging in the region, has presented its results and its impact on society, within the Spanish-speaking meeting ‘ Forum of Iberian Stories. 30 years of the INTERREG Spain-Portugal Cross-Border Cooperation Program (POCTEP) ’. Specifically, the event has been organized by the agencies EFE and LUSA, and took place this past Wednesday at the headquarters of the Spanish agency in Madrid, with the support of the Directorate General for Regional Policy (DGRegio) of the European Commission. Its[...] 28 Jan Researchers of NANIOSIS Unit 14 at JUMISC have published a new book titled Basic research procedures in the cell therapy laboratory, in which some basic techniques and general principles for adult stem cell research are explained. Stem cells are cells capable of differentiating into a wide variety of cell types and can be isolated from different tissues such as. They have regenerative and anti-inflammatory properties thanks to the secretion of paracrine factors. Currently, these cells are being widely used in clinical trials for the treatment of different diseases such as Crohn disease, multiple sclerosis, diabetes, rheumatoid arthritis or myocardial infarction.[...] 28 Jan Jose Luis Pedraz, Jesus Ciriza and Angela Losada of NANBIOSIS U10 Drug Formulation – NanoBioCel Group of CIBER-BBN and University of the Basque Country were in Leuven, Belgium attending the European Project POSITION-II Workshop #5, which was held between January 21 and 23. The workshop was held at the facilities of iMEC, one of the partners of the project and world leader in R&D in nanoelectronics and digital technology. The project lasts three years and after 18 months, in this workshop, the researchares of NANBIOSIS U10 Drug Formulation, have microencasulated and characterized the heart cells with the aim of checking[...] 27 Jan La Vanguardia and the Fundació Catalunya La Pedrera have jointly promoted for the tenth consecutive year the Cutting-Edge Science Award “La Vanguardia de la Ciencia”, with the objective of givin visibility to the research of excellence carried out in Spain. The prize will correspond to the proposal candidate most voted by the public. One of the 8 selected candidates is the research led by Anton Guimerà-Brunet (NANBIOSIS Unit 8 -Institut de Microelectrònica de Barcelona-CNM-CSIC / CIBER-BBN) and Jose Garrido (Institut Català de Nanociències i Nanotecnologia / Icrea), for developing graphene implants capable of measuring the hidden activity of the brain[...] 26 Jan From the NFP research group of CIBER-BBN and INA, led by Jesus Santamaria, that coordinates NANBIOSIS U9 Synthesis of Nanoparticles Unit, and through the SAMCA Nanotechnology Chair, the call for grants has been launched: Nanotechnological Bonds For more information: http://capsulasdenanotecnologia.es/bonos-nanotec/[...] 24 Jan The Piccolo consortium members met at JUMISC (Cácere) last on 21st-22nd January to hold the 7th face-to-face meeting. Project partners had the chance to visit Nanbiosis U21 Experimental operating rooms led by Francisco M. Sánchez Margallo and participate in a training session with the prototype demo. A murine specimen was analysed ex-vivo with the probe and the clinicians had the opportunity to evaluate the features present in a neoplastic polyp. The meeting agenda included a general overview of the project, the status update of OCT (Optical Coherence Tomography), MPT (Multiphoton Tomography) and fluorescence technologies, deep learning algorithms preliminary results, t[...] 23 Jan JUMISC has organised the II Course for the performance of functions A, B and C in rodents, lagomorphes, carnivores, pigs and small rumiants which wil take place at JUMISC from 3 February to 20 March co-Directed by D. LUIS DÁVILA GÓMEZ, Scientific Director of NANBIOSIS U22. Animal housing and DR. FRANCISCO MIGUEL SÁNCHEZ MARGALLO (Deputy Scientific Director of NANBIOSIS) The total duration of the course is 100 hours (58 theory and 42 practice) This course has as specific objectives to provide information and expand existing knowledge in the following aspects: -Specific legislation regarding animal experimentation . -Ethical considerations and the principles of replacement, reduction and refinement. -Biology, housing, handling and care of experimental animals. -Occupational health and safety. -Recognition of the stat[...] 20 Jan Nitric oxide is a component of the pollutant nitrogen oxides (NOx) responsible of different environmental negative effects. However, due to its physiological effects, NO has been used in different therapeutic applications. Thus, the inhaled nitric oxide (iNO) is a selective pulmonary vasodilator that finds its best applications in pediatrics, by transiently improving oxygenation in respiratory failure and persistent pulmonary hypertension. The initial recommended concentration of iNO in these treatments is 20 ppm. Higher concentrations do not increase its effectiveness and are associated with a higher incidence of methemoglobinemia and formation of nitrogen dioxide. In consequence the control of iNO concentration is[...] 17 Jan The IV course on Tumor Immunology and Cancer Immunotherapy will start on 6th Feb, 2020. On April 2 at 7:00 pm Iñaki Ochoa will teach about “Basic research in cancer immunotherapy. Use of microfluidics in the study of cancer immunotherapy“. Ignacio Ochoa is a Professor of the Department of Human Anatomy and Histology of the University of Zaragoza and researcher of the AMB – Applied Mechanics and Bioengineering group and NANBIOSIS U13 Tissue & Scaffold Characterization Unit from CIBER-BBN and I3A-Zaragoza University Classes will be held on Thursday, from 4:00 p.m. to 8:00 p.m., in the CIBA Lorente de Nó[...] 16 Jan Researchers of CIBER-BBN and NANBIOSIS-ICTS (U6 Biomaterial Processing and Nanostructuring Unit at ICMAB-CSIC and U18 Nanotoxicology Unit at Hospital de la Santa Creu i Sant Pau have developed a new nanocarrier for bio-imaging and drug-delivery applications The new nanovesicle formulation is based on the quatsome architecture – which stands out due to the high colloidal stability and homogeneity in size – and has now been shown to be suitable for in vivo dosing. Quatsomes are new non-liposomal lipid-based nanovesicles that have been developed by Nanomol group in recent years, and have been shown to be highly homogeneous and stable in[...] 15 Jan CCMIJU has organised the II Urological Laparoscopy Course: Suture Management and Intracorporeal Knotting which wil take place at JUMISC from 3 to 5 February under the Direction of Álvaro Serrano Pascual (Urology Service Specialist at the San Carlos Clinical Hospital, Madrid) and Francisco Miguel Sánchez Margallo (Deputy Scientific Director of NANBIOSIS) It is a basic course of Laparoscopic Urology where the techniques of Laparoscopic Radical and Partial Nephrectomy will be carried out. The objective of this course is for specialists in Urology to improve their skills in suture management and intracorporeal knotting. Programm and inscriptions her[...] 11 Jan Researchers of NANBIOSIS U6. Biomaterial Processing and Nanostructuring Unit have just published the article titled “An enantiopure propeller ‐ like trityl ‐ brominated radical: Bringing together a high racemization barrier and an efficient circularly polarized luminescent magnetic emitter” in the scientific magazine Chemistry A European Journal. The urgent need to cope with the more and more specific requirements in electronic devices is nowadays behind the search for new multifunctional materials. In this work, a step forward has been done in the field of organic free radicals acting as chiral emitters. The recently developed brominated trityl derivative, namely TTBrM radical, shows[...] 30 Dec Researchers of NANBIOSIS Unit 1 and NANBIOSIS Unit 18, led by Prof Antoni Villaverde have published the article at the prestigious scintific magazine titled Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer The researchers have shown that the combination of cell-penetrating and tumor cell-targeting peptides dramatically enhances precise tumor accumulation of protein-only nanoparticles intended for selective drug delivery, in mouse models of human colorectal cancer. This fact is a step forward for the rational design of multifunctional protein nanomaterials for improved cancer therapies. Protein production has been partially performed by the ICTS NANBIOSIS U1, Protein Production Platform[...] 28 Dec Maria Pilar Marco Colás has been honored by the Spanish National Research Council (CSIC) in appreciation for having complited 25 years of work at the CSIC, an intense period of 25 years at the service of Science, 11 of them as Scientific Director of Custom Antibody Service (CAbS), unit 2 of NANBIOSIS since its inclusion in the national ICTS map.[...] 27 Dec Cell-selective targeting is expected to enhance effectiveness and minimize side effects of cytotoxic agents. Functionalization of drugs or drug nanoconjugates with specific cell ligands allows receptor-mediated selective cell delivery. However, it is unclear whether the incorporation of an efficient ligand into a drug vehicle is sufficient to ensure proper biodistribution upon systemic administration, and also at which extent biophysical properties of the vehicle may contribute to the accumulation in target tissues during active targeting. To approach this issue, structural robustness of self-assembling, protein-only nanoparticles targeted to the tumoral marker CXCR4 is compromised by reducing the number of histidine residues (from[...] 23 Dec Researchers from NANBIOSIS-CIBER-BBN have developed a new type of protein biomaterial that allows a continuous release over time of therapeutic proteins when administered subcutaneously in laboratory animals. These results are the result of the stable scientific collaboration between the researchers of NANBIOSIS Units 1 Protein Production Platform (PPP)and 18 Nanotoxicology Unit, led by Toni Villaverde and Ramón Mangues at the Institute of Biotechnology and Biomedicine of the Autonomous University of Barcelona (IBB-UAB) and the Institut About the Hospital de Sant Pau and has had the participation of the Institute of Biological and Technological Research of the National University of Córdoba-CONICET,[...] 17 Dec Oligonucleotide-protein conjugates have important applications in biomedicine. Four units of NANBIOSIS have collaborated to come across with more simple and efficient methods for the preparation of these conjugates. In the publication of the research results, a new method is described in which a bifunctional linker is attached to thiol-oligonucleotide to generate a reactive intermediate that is used to link to the protein. Having similar conjugation efficacy compared with the classical method in which the bifunctional linker is attached first to the protein, this new approach produces significantly more active conjugates with higher batch to batch reproducibility. In a second approach,[...] 16 Dec Researchers of NANBIOSIS Unit 1 and NANBIOSIS Unit 18, led by Ramón Mangues, have published the article titled CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models . One-third of diffuse large B-cell lymphoma patients are refractory to initial treatment or relapse after rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy. In these patients, CXCR4 overexpression (CXCR4+) associates with lower overall and disease-free survival. Nanomedicine pursues active targeting to selectively deliver antitumor agents to cancer cells, a novel approach that promises to revolutionize therapy by dramatically increasing drug concentration in target tumor cells. In the study carried out[...] 13 Dec ‘I investigate, I am CSIC’ is a competition hold by The Spanish National Research Council (CSIC) for its doctoral students to disseminate their doctoral thesis. Through short videos of maximum duration of 3 minutes, predoctoral scientists explain their research and results in an informative language. Miguel Zea, a member of the NANBIOSIS U8 Micro– Nano Technology Unit presents his video explaining how paper sensors can be manufactured to control different analytes with low cost technologies such as Inkjet Printing. A jury composed of five experts in communication or scientific dissemination will choose eight videos taking into account the originality, impact,[...] 09 Dec NANBIOSIS U18 Nanotoxicology Unit, led by Dr. Dr. Ramón Mangues, has recently added new equipment as a result of its participation in the project FICTS1420-20, selected by the MINECO for co-financing by the FEDER Program in ICTS 2014-2020. The new equipment consists in a Autostainer System for the automation of manual staining methods used in Immunohistochemistry, pharmacodiagnostic, immunofluorescence and chromogenic development for in situ hybridization (AUTOSTAINER-TOX). Includes small equipment for deparaffinization, hydration and antigenic unmasking of paraffin-embedded tissue, complete kit for deparaffinization, hydration and antigenic unmasking of paraffin-embedded tissue. The equipment management software allows monitoring of staining status, request requests, and reporting and obtaining[...] 04 Dec The IBEC Core Facilities team, coordinating NANBIOSIS U7 Nanotechnology Unit has celebrated the 6th edition of the Workshop “Tips and tricks to achieve good results at the bench”. This workshop is focused on fundamental basic aspects of working in a Chemistry/Biology laboratory: process of performing an experiment, from previous planning until the moment of leaving the bench. The workshop was divided in two parts: Introduction and overview to the Good Laboratory Practices.Highly interactive and practical daily lab situations with real equipment. Upon completion of this workshop participants are able to understand the basics of good laboratory practices, plan an experiment[...] 02 Dec Carlos Rodriguez-Abreu, Scientific Director of NANBIOSIS U12 Nanostructured liquid characterization unit has been invited speaker at OKINAWA COLLOIDS 2019 conference in Okinawa, Japan on November 3 to 8, 2019 in the session Foams / Bubbles / Emulsions and Microemulsions.Foams and emulsions stabilized by surfactants, amphiphilic polymers and solid particles are essential formulations for developing pharmaceuticals, cosmetics, foods and so on. Recently, many functional systems have been proposed including stimuli responsive materials, biocompatible materials, and environmental affinity materials. The topics of this session include a wide range of subjects: physical properties, phase behaviors and new functions of these systems.[...] 27 Nov NANBIOSIS has celebrated today the second edition of NANBIOSIS internal dissemination day, at the ICMAB-CSIC, Barcelona. The Day has been focuss on the staff that deals with the day-to-day work of the units, especially technical staff. The event was attended by technicians and coordinators of the units of Catalonia and Aragon (almost 30 face-to-face assistants) and has been followed through the streaming broadcast by the other units. The day has been presented by the NANBIOSIS Scientific Director Jaume Veciana and the Nerea Argárate Coordinator, followed by a round of presentations by the attendees and their work in the different NANBIOSIS[...] 26 Nov We are pleased to inform that the new book of Unique Scientific and Technical Infrastructures (ICTS) has been published by the Spanish Ministery of Innovation, Science and Universities with the collaborations of the ICTS. The Spanish Map of Unique Scientific and Technical Infrastructures (ICTS), goups biomedical technologies, cleanrooms, supercomputers, advanced lasers, telescopes, underground laboratories, synchrotrons, particle accelerators, biological reserves, solar, oceanic and hydraulic platforms, oceanographic research ships, and polar bases in Antarctica. A total of 29 ICTS, made up of 62 nodes, allow for ambitious research projects that attract first-rate talent and enhance the technological and innovative industry capacities. “Through a[...] 25 Nov In the framework of the FEDER Program in ICTS 2014-2020, a project related to the ICTS NANBIOSIS has been selected by the Ministry of Science, Innovation and Universities for co-financing with FEDER funds of the European Regional Development Funds program. An agreement has been signed between the Ministry of Science, Innovation and Universities and the Institute of Bioingeniería of Catalonia (IBEC) for the implementation of the project “Mask Aligner Team for the unit of Nanotechnology (U7) of Nanbiosis” cofinanced by FEDER Performance Program 2014-2020. The total budget of the project amounts to € 117.000, with 50% financing with FEDER Funds. IBEC isprocessing t[...] 22 Nov The Jesús Usón Minimally Invasive Surgery Center (JUMISC), organizes the 1st ONLINE Course on Introduction to Quality Management in Laboratories in the Biosanitary Field. The course will count with the expertise Beatriz Moreno Lobato, Scientific Director of NANBIOSIS Unit 19 CLINICAL TEST LAB, among others. The Course is directed to middle-level technicians: Auxiliary Care of Nursing and Pharmacy and Parapharmacy and also to higher degree technicians: Pathological and Cytodiagnostic Anatomy, Oral Hygiene, Image for Diagnosis and Nuclear Medicine, Clinical and Biomedical Laboratory, Dental Prosthetics, Dietary The course has a capacity for forty attendees and registration is now open here: T[...] 12 Nov Pablo Laguna Lasaosa, New Director of I3A and scientific director of NANBIOSIS U27 High Performance Computing talks about Biomedical Engineering in the radio programm “La Brujula de Aragón” @OndaCero_ Professor of signal and communications, expert of biomedical signals in the cardio vascular domain, Pablo Laguna talks about engineering today and how the relative weight of engineering is nowadays repesented by the information engineering, computer engineering and the treatment of information to be applyed in different domains, new materials and new ways of addressing and solving problems. For the recently appointed director of the I3A, there is an opportunity in this[...] 11 Nov Pablo Laguna Lasaosa, Scientific Director of Unit 27 High Performance Computing has been elected new director of the Aragon Engineering Research Institute (I3A). Pablo Laguna Lasaosa, Professor of Signal Theory and Communications at the School of Engineering and Architecture (EINA) of the University of Zaragoza, develops its research activity in the field of signal processing, particularly applied to biomedical applications. Laguna is co-author of more than 150 research articles on this subject, more than 10 book chapters, more than 300 international conference documents and director of 15 doctoral theses. He has led a good number of projects on the interpretation[...] 10 Nov The III Conference for the Disclosure of Biomedical and Experimental Sciences will take place at the Center for Minimally Invasive Surgery Jesús Usón of Cáceres, on December 5, 2019. It will be attended by Francisco Miguel Sanchez Margallo, Deputy Scientific Director of NANBIOSIS and Beatriz Moreno Lobato, Scientific Director of Unit 19 of NANBIOSIS FREE ACTIVITY – Requires prior registration until full capacity is reached Pre- registration: https://www.ccmijesususon.com/formacion/preinscripcion/1173/ Program: Detalle de Curso[...] 09 Nov Jesús Marcos Santamaría Ramiro, Scientific Director of NANBIOSIS Unit 9 Synthesis of Nanoparticles Professor of Chemical Engineering at the University of Zaragoza and Deputy Director of the University Institute of Nanoscience of Aragon has been appointed new Corresponding Academician of the Royal Canary Academy of Sciences. Reception of the new Corresponding Academician took place last November 7th at the Hall of the Canary Islands Advisory Council in La Laguna the entry speech of the new Corresponding Academician was tittled “Heterogeneous Catalysis 4.0: Opportunities for catalysts when they leave the reactor”[...] 08 Nov A study result of collaboration between researchers of two NANBIOSIS units managed to produce a potent antitumor effect in an animal model with non-Hodgkin lymphoma A non-Hodgkin’s lymphoma, NHL is a cancer that starts in white blood cells called lymphocytes, which are part of the body’s immune system. Lymphoma. NHL is a term that’s used for many different types of lymphoma that share some characteristics. The most prevalent type of non-Hodgkin lymphoma is called diffuse large B-cell lymphoma (LDCGB). Although there are treatments for this pathology, there are non-responders. This nanoparticle can be developed as a nanopharmaceutical, in order to introduce a new treatment, whic[...] 07 Nov Amable Bernabé, Technical Coordinator of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit has given a course from Monday, 7 October, to Wednesday, 9 October on “Characterization techniques for particulate materials”. The course has counted with 12 participants from different CSIC centers (including ICMAB, IBM-CNM, ICM, IQAC…) and has introduced the participants to different techniques to characterize nanoparticles and other particulate matter, including the basic fundamentals, sample preparation, practical examples and results interpretation. It is the second time that Amable Bernabé, technician from the Sof tLab, has decided to offer this course to all the CSIC community, so they can learn new methods to characterize nanoparticles,[...] 06 Nov Ana Moya, Xavi Illa, Rosa Villa and Gemma Gabriel, researchers of the Biomedical Application’s Group (GAB) of CIBER-BBN and the Microelectronics Institute of Barcelona, which main interests are the design and fabrication of Micro and Nano Systems for Biomedical Applications, have recently published, in collaboration with other authors an article in the Special Issue Advanced Electrochemical Sensors and Environmental Monitoring The authors thank in the Acknowledgements the participation of the ICTS NANBIOSIS U8 Micro– Nano Technology Unit of the CIBER in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) at the IMB -CNM (CSIC) The work reports the development of a novel multi-analyte microsensor[...] 06 Nov Jaume Veciana, Scientific Director of NANBIOSIS is coauthor of an article chosen to be highlighted on the ChemistryViews newsletter: “Organic Free Radicals as Circularly Polarized Luminescence Emitters”, published in Angewandte Chemie International Edition, and is about the intrinsic chiral emission of enantiometric organic free radicals. The short news about the paper is entitled “Circulary Polarized Light from Organic Radicals” is available here. Circularly polarized luminescence (CPL) can occur when a luminescent compound has a chiral structure. Organometallic structures are leading in CPL activity. However, purely organic CPL emitters are promising alternatives in several applications where low toxicity is important (i.e., bioimaging). Jaume Veciana (Institut de Ciéncia de Materials de Barcelona (ICMAB), Spain), Araceli G. Campaña (University of Granada, Spain)[...] 05 Nov On October 25, the Monitoring Commission of the agreement signed on July 15 was established by the Ministry of Economy, Industry and Competitiveness and the University of Extremadura for the acquisition of new equipment that will expand the capabilities of Unit 16 of NANBIOSIS. One of the 26 Units that constitute NANBIOSIS is Unit 16 “Unit of Surface Characterization and Calorimetry” of CIBER-BBN and the University of Extremadura. The application of this FEDER cofinancing will allow the expansion of the capabilities of this unit for the chemical, physicochemical, and topographic characterization of surfaces, improving the competences in mass spectrometry by[...] 03 Nov Researchers of NANBIOSIS U9 Synthesis of Nanoparticles Unit Ignacio Julian, José L. Hueso, Reyes Mallada and Jesús Santamaría, are co-authors of an article with inside backcover recently published by the scientific magazine Catalysis, Science and Tecnology. The synthesis of the materials has been performed at the Platform of Production of Biomaterials and Nanoparticles of the NANBIOSIS ICTS, more specifically at the Nanoparticle Synthesis Unit 9 of the CIBER in BioEngineering, Biomaterials & Nanomedicine (CIBER-BBN) Article: Polyoxometalates as alternative Mo precursors for methane dehydroaromatization on Mo/ZSM-5 and Mo/MCM-22 catalysts. Julián I, Hueso J.L, Lara N, Solé-Daurá A, Poblet J,M, Mitchell S.G, MalladaR, Santamaría J.Catal. Sci.[...] 02 Nov During de dates Nov. 18 -30, 2019 will take place de course on line on Introduction to Research and Laboratory Techniques in Biociences, under the direction of NANBIOSIS U14 Cell Therapy Unit led by Javier García Casado Scientific Director of the Unit and Francisco M. Sánchez Margallo Scientific Director of CCMIJU and Deputy Scientific Director of NANBIOSIS. For further information: Online Course on INTRODUCTION TO RESEARCH AND LABORATORY TECHNIQUES IN BIOCIENCES Matriculación onlin[...] 01 Nov The Nanobiotechnology for Diagnostics group (Nb4D) of CIBER-BBN and IQAC-CSIC, (coordinator of NANBIOSIS U2 Custom Antibody Service (CAbS)), led by Prof. Mª Pilar Marco, is organizing a workshop on “Ethical aspects of research” netx 18th November 2019, at the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC). There will be three sessions given by experts from this topic area. TECHNOLOGICAL ADVANCES VERSUS ETHICS by Dr. José Ignacio Latorre ANIMAL TESTING by Dr. Lluís Montoliu CLINICAL SAMPLES, BIOBANKS AND OTHER ASPECTS IN CLINICAL PRACTICE by Dr. Pieter Moons A Certificate of Attendance will be issued for each participant. This workshop is FREE but has LIMITED SPACE. To register, fill in the form by 10th November[...] 31 Oct “Selectively humanized nanomedicines aimed at killing CXCR4 + tumor cells for the treatment of acute myeloid leukemia” is one of the Project awarded by La Marató TV3 Foundation and is participated by Dr. Antonio Villaverde, Estrategic of NANBIOSIS U1 Protein Production Platform (PPP) The main objective of the project is the design and validation of humanized protein nanoparticles for the targeted delivery of antitumoral drugs for the treatment of acute myeloid leukemia. This will be done by the generation of protein-based nanoconjugates that will be targeted to the cytokine receptor CXCR4, overexpressed in this human neoplasia. The drugs will consist[...] 30 Oct Jesús Santamaría, who leads the NFP research group of CIBER-BBN and the Institute of Nanoscience of Aragon (INA), at the University of Zaragoza, in an interview on October 29 to Aragon TV, talks about the problems in the fight against cancer and explains in a very didactic way, the solutions that are being approached from his research group, in collaboration with other groups. It would consists, basically, in reducing the tumor from inside the tumor cells. Prof. Santamaria has been granted funding twice from the European Research Council (ERC) Advanced Grant program for catalysis-related projects, the last one with two[...] 29 Oct “Minimal invasion, maximum innovation” is a repot by Spanish TV about the Minimal Invasion Surgery Center, Jesús Usón, partner of NANBIOSIS. “The unique capabilities of the Center from its animal farm to its surgical infrastructure allow the evaluation and validation of new technology such as medical devices, new biomaterials, new pharmacological therapies, before being used in human patients” explains Francisco Miguel Sanchez Margallo, Sciencitific Director of the Center and Deputy Scientific Director of NANBIOSIS- ICTS. Verónica Crisóstomo, Scientific Director of NANBIOSIS Unit 24 of Medical imaging explains a current project that studies how to reduce the damage caused by a[...] 28 Oct Researchers of Unit 17 of NANBIOSIS Confocal Microscopy Service and the GITBIT-UAH group (CIBER-BBN, Univerty of Alcalá de Henares), have been awarded with the PRIZE FOR THE BEST POSTER COMMUNICATION by the Spanish Society of Nephrology (S.E.N.) and Senefro Foundation. “The ILK deletion prevents extravasation of monocytic line leukocytes induced by the accumulation of uremic toxins during chronic kidney disease” authored by CAMPILLO DE BLAS, L BOHORQUEZ MAGRO, D GARCÍA AYUSO, B GARCÍA CARRASCO, M GRIERA, S DE FRUTOS, M RODRÍGUEZ-PUYOL, D RODRÍGUEZ-PUYOL, L CALLEROS BASILIO.[...] 26 Oct Carlos Rodríguez-Abreu, Scientific Director of NANBIOSIS Unit 12 Nanostructured liquid characterization unit, from Institute of Advanced Chemistry of Catalonia, Higher Council for Scientific Research (IQAC-CSIC) and CIBER of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) has participated in the fourth edition of COSMETORIUM, given a talk on “Recent advances in the formulation of emulsions” The fair of Cosmetorium, which was held at the Palau de Congresos de Barcelona on October 23 and 24, is organized by the Spanish Society of Cosmetic Chemists (SEQC), begun with keynote conferences and a scientific program, which examined the key problems facing the cosmetic and personal care industry,[...] 23 Oct On October 21 and 22, CIBER-BBN has celebrated its 13th Annual Conference in Tarragona, with a session dedicated to NANBIOSIS on the afternoon of Monday 21. The Singular Technical Scientific Infrastructure (ICTS) for the production and characterization of biomaterials, nanomaterials and devices up to its preclinical validation for the production and characterization of biomaterials, nanomaterials and devices up to its preclinical validation is integrated by of the CIBER-BBN, the Minimally Invasive Surgery Center Jesus Usón and Bionand after its incorporation to the ICTS last year. NANBIOSIS, presented its annual activity. The Session was chaired by its Scientific Director, Jaume Veciana who also gav[...] 16 Oct Sara Larriba of the Human Molecular Genetics Group of Bellvitge Biomedical Research Institute (IDIBELL) has informed NANBIOSIS about a recent publication mentioning NANBIOSIS in the Acknowledgements for its participation in the results of their research. (The nanoparticle tracking analysis was performed by the ICTS NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit) The article has been published by the journal Scientific Reports of Nature Research. The prediction of PCa in the early stage of the disease is one of the most important objectives in male urology. A significant decrease in deaths due to PCa has been associated with the use of serum[...] 15 Oct Nanbiosis-ICTS and CIBER-BBN were present at BioNanoNet Annual Forum & Networking event and the Austrian Microfluidics Initiative (AMI) workshop “Biomedicine on Chip” that took place on 10-11th of September 2019 at the premises of the University of Salzburg attracting about 40 participants from both science and industry. For furher information: https://www.bionanonet.at/; www.microfluidicsaustria.at[...] 10 Oct NANBIOSIS U25 scientific coordinator, Ana Paula Candiota, has recently presented a scientific work about preclinical brain tumour therapy response assessment with MRSI approaches in the 36th annual meeting of ESMRMB held in Rotterdam, Netherlands, October 3-5. Work was entitled “Oscillatory pattern of response in MRSI-based Glioblastoma therapy follow-up: an immune system biomarker?” and was awarded an oral presentation in the scientific session of Animal Models: Brain & others Article of refrence: L. Villamañan, P. Calero, S. Wu, N. Arias-Ramos, M. Pumarola, S. Ortega-Martorell, M. Julià-Sapé, C. Arús, A.P. Candiota. Oscillatory pattern of response in MRSI-based Glioblastoma therapy follow-up: an immune system[...] 05 Oct Researchers of NANBIOSIS Unit 26 NMR: Biomedical Applications II have recently published an article in the scientific journal Science and Technology of Advanced Materials, Four types of calcined MCM-41 silica nanoparticles, loaded with dyes and capped with different gating ensembles are prepared and characterized. N1 and N2 nanoparticles are loaded with rhodamine 6G and capped with bulky poly(ethylene glycol) derivatives bearing ester groups (1 and 2). N3-N4 nanoparticles are loaded with sulforhodamine B and capped with self-immolative derivatives bearing ester moieties. In the absence of esterase enzyme negligible cargo release from N1, N3 and N4 nanoparticles is observed whereas a remarkable release for N2 is obtained most likely due to the formation of an[...] 01 Oct CIBER-BBN is looking for proyect manager for a european project in biomedicine to coordinate NANBIOSIS units participation in the project. The position requires good command of English and strong skills in coordinating researchers. Applications must be filed at CIBER’s web portal untill October 15.[...] 21 Sep In one month CIBER-BBN will celebrate its 13th Annual Conference on October 20 and 21 in Tarragona, at the Hotel Ciutat de Tarragona, Tarragona. This year there several scientific sessions are planned about related leading issues with research topics of interest to CIBER-BBN. On Monday there will be three sessions centered in: artificial intelligence and big data gene editing and CRISPR and liquid biopsy and point-ofcare. Each of these sessions will include a plenary conference given by an expertguest and two talks by BBN researchers, followed by an open debate. The program will complete a session focused on the Singular Technical Scientific Infrastructur[...] 15 Sep NANBIOSIS U10 Drug Formulation unit, led by Dr. José Luis Pedraz, has recently added new equipment as a result of its participation in the project FICTS1420-20, selected by the MINECO for co-financing by the FEDER Program in ICTS 2014-2020. The new equipment includes: Equipment of biopharmaceutical characterization of pulmonary formulations with Breath Simulator and Alberta Idealised Throat (AIT) NGI cascade Impactor: an analytical tool for the development of inhalation products. It’s use for the testing of all inhalation formulations and devices: MDIs, DPIs, nebulizers and aerosol and nasal sprays Malvern Spraytec: It’s a laser diffraction system allows measurement of spray particle and spray droplet[...] 23 Aug Three units of NANBIOSIS have collaborated in obtaining the research results published in the article “Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies” published by Advanced Science Protein production and DLS have been partially performed by the Unit 1 of ICTS NANBIOSIS Protein Production Platform (PPP) and the Unit 6 NANBIOBIS Biomaterial Processing and Nanostructuring Unit. Biodistribution and immunohistochemistry assays were performed at NANBIOSIS U20 In Vivo Experimental Platform/FVPR Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44‐targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types[...] 22 Aug Next October 15-18, the researchers of NANBIOSIS U12, Nanostructured liquid characterization unit, are giving a course on Nano Technologies and Microencapsulation organized by CSIC General Foundation and CUIMPB – Center Ernest Lluch of the Menéndez Pelayo International University (UIMP) in Barcelona. The nano- and microencapsulation consists in the protection of active substances inside nano- and microcarriers, particularly labile molecules, improving their stability, with the aim of transporting them and achieving their controlled release. This topic is the subject of great interest in numerous fields and industrial applications. It is known that the performance efficiency of an active substance greatly increases[...] 21 Aug The researchers of NANBIOSIS U20, led by Ibane Abásolo and Simó Schwartz have published a new article on the scientific magazine Cancers, with the title Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells All the in vivo studies were performed by NANBIOSIS U20 In Vivo Experimental Platform. Therapeutic resistance seen in aggressive forms of breast cancer remains challenging for current treatments. More than half of the patients suffer from a disease relapse, most of them with distant metastases. Cancer maintenance, resistance to therapy, and metastatic disease seem to be sustained by the presence of cancer stem[...] 20 Aug Researchers of Nanomol Group, coordinator of NANBIOSIS U6 of CIBER-BBN and ICMAB-CSIC, led by Inma Ratera and Jaume Veciana have publish a new article titled “Reversible switching of the Au(111) work function by near infrared irradiation with a bistable SAM based on a radical donor–acceptor dyad“, at Journal of Materials Chemistry C. Article: https://pubs.rsc.org/en/content/articlelanding/2019/TC/C9TC00906J#!divAbstract[...] 17 Aug The Academic Ranking of World Universities (ARWU), known as Shanghai Ranking, which was made public on August 15, places the Autonomous University of Barcelona among the elite of the 300 best universities in the world. This indicator organizes up to 20,000 university centers worldwide, based on transparent methodology and objective third-party data. ARWU is regarded as one of the three most influential and widely observed university rankings The Autonomous University of Barcelona houses two of NANBIOSIS Units: U1 Protein Production Platform (PPP), led by Toni Villaverde, Neus Ferrer and Paolo Saccardo, offer an “tailored” service for the design, production and purification[...] 16 Aug The Academic Ranking of World Universities (ARWU), known as Shanghai Ranking, which was made public on August 15, once again places the University of Zaragoza among the elite of the 500 best universities in the world. This indicator organizes up to 20,000 university centers worldwide. Among the keys that have been able to positively influence the results of the research, according to the Vice Chancellor for Prospect, Sustainability and Infrastructure of the University of Zaragoza, Francisco Serón, are the increase in public campus funding for four years as well as the quality of their Scientists. The University of Zaragoza houses[...] 02 Aug Researchers of CCMIJU. led by Javier G. Casado, Scientific Director of NANBIOSIS U14 Cell Therapy, are coauthors of the article “Extracellular vesicles derived from endometrial human mesenchymal stem cells enhance embryo yield and quality in an aged murine model” published by. Biology of Reproduction, The study of the beneficial effect of endometrial stem cell exosomes on embryonic quality has been developed in NANBIOSIS U14 and in collaboration with U22 and U23 Advanced age is a risk factor undermining women’s fertility. Hence, the optimization of assisted reproduction techniques is an interdisciplinary challenge that requires the improvement of in vitro culture systems. Here, w[...] 30 Jul Researchers of the Nanomol group, ICMAB-CSIC and CIBER-BBN members of the ICTS “NANBIOSIS”, specifically of the Biomaterial Processing and Nanostructuring unit (U6), together with the company Nanomol Technologies S.L. have begun a consultation process with the Spanish Association of Medicines and Health Products (AEMPS) to try and enter a new treatment in a clinical studies stage, to fight against venous ulcers in lower extremities. The study is carried out within the framework of the RIS3CAT NANONAFRES project. Approximately, 80% of ulcers in lower extremities have associated pathologies of venous insufficiency and these wounds are usually recurrent. An open ulcer can[...] 29 Jul Last week took place on Berlin the EMB Conference 2019, (the 41st International Engineering in Medicine and Biology Conference) with the overarching theme “Biomedical engineering ranging from wellness to intensive care” counting with plenary keynotes from leading academic and industrial scientists, who presented aspects of innovation and translational engineering in biomedicine. Pablo Laguna, Scientific Director of NANBIOSIS Unit 27, from CIBER-BBN and I3A-UZ, was invited to give a talk on the topic “Phisiologically Driven Biomedical Signal Processing: making the most of Signals” Pablo Laguna has co-authored more than 150 research papers on this topic, over 300 international conference papers, and has advise 15 Ph.D[...] 18 Jul Last week, representatives of NANBIOSIS and OmicsTech met at the IQAC-CSIC facilities in Barcelona to exchange common research lines, points of view of their complementarity and collaboration possibilities of the facilities, both recognized as Unique Scientific Technical Infrastructure (ICTS) by the Spanish Government. The Infrastructure for Omics Technologies OmicsTech ICTS is a distributed infrastructure that offers researchers the possibility of using globally competitive singular facilities exclusively dedicated to work with omics technologies, with a spectrum of biomolecular analysis tools for holistic capture of biological processes, to support research, technological development, and innovation activities. Advances in genomics, proteomics and metabolomics technologies have opened[...] 18 Jul In the framework of the FEDER Program in ICTS 2014-2020, a projects related to the ICTS NANBIOSIS has been selected by the Ministry of Science, Innovation and Universities for co-financing with FEDER funds of the European Regional Development Funds program. An agreement has been signed between Ministry of Science, Innovation and University of Extremadura, institution that houses NANBIOSIS unit 16 for the co-financing of the Project FICTS1420-14-09: “Compra e instalación y puesta a punto de equipamiento de caracterización para complementar la Unidad 16 de NANBIOSIS – Surface Characterization and Calorimetry Unit –NANBIOSISU16”.[...] 27 Jun Last June 18-22 at the 2019, ESC meeting, the European Students Colloid Conference, that took place in Varna, Bulgaria, Judit Tomsen, PhD fellow at the Nanomol group from CIBER-BBN and ICMAB-CSIC, was awarded with the best oral presentation. Judit Tomsen, who carries out her work under supervision of Nora Ventosa, Scientific Director of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit, presented her oral communication entitled “Design of peptide targeted nanovesicles for the α-galactosidase A enzyme delivery“. Her talk explained some of the smart4fabry european project results, a project coordinated by CIBER-BBN and Nora Ventosa in which participates NANBIOSIS Unit 6. The European Colloids and Interfaces Society (ECIS) organizes biannually ESC meetings of advanced students at PhD and MSc[...] 25 Jun From the NFP research group of CIBER-BBN and INA, led by Jesus Santamaria, that coordinates NANBIOSIS U9 Synthesis of Nanoparticles Unit, and through the SAMCA Nanotechnology Chair, the call for grants has been launched: Nanotechnological Bonds For more information: http://capsulasdenanotecnologia.es/bonos-nanotec/[...] 24 Jun Last week took place in Braga, Portugal, the Nanomed Europe Conference, NME19, a new and unique conference born from the merge of the 14th annual event of the ETPN & the European scientific conference ENM (after London 2017 & Grenoble 2015), bringing together scientists, technology providers, entrepreneurs, industry and clinicians, all of them developing great medical applications of Nanotechnologies and emerging MedTech. The event is been co-organized this year by the ETPN and INL. Simó Schwartz, Scientific Director of NANBIOSIS U20, was one of the selected speakers and gave a lecture about “Preclinical development of magnetic nanoparticles for the treatment of pancreatic cancer” Two posters mentioning t[...] 21 Jun In the framework of the FEDER Program in ICTS 2014-2020, a projects related to the ICTS NANBIOSIS has been selected by the Ministry of Science, Innovation and Universities for co-financing with FEDER funds of the European Regional Development Funds program. An agreement has been signed between Ministry of Science, Innovation and UPV/EHU (University of the Basque Country ), institution that houses NANBIOSIS unit 10 for the co-financing of the Project FICTS-1420-17: “Purchase and installation and set-up of characterization equipment to complement Unit 10 of drug formulation”.[...] 12 Jun Researchers of NANBIOSIS units at JUMISC have recently published the results of an study that highlights the promising application of laparoscopy for graft procurement surgery in uterine transplantation from living donors for absolute uterine infertility treatment. Laparoscopy seems to be a safe, time saving, useful and technically feasible surgical procedure for uterus extraction, with the additional benefits of minimally invasive surgery. It was also demonstrated that after a successful uterine transplant, pregnancy can be achieved by combining laparoscopy for uterine retrieval and microsurgery for vascular anastomosis. With the increasing success rate of human uterus transplantation trials from living donors, it[...] 04 Jun In the last decades, increased resistance to conventional antibiotics has led to important research in the development of alternative strategies for preventing pathogen dissemination. Antimicrobial surfaces containing a biocidal agent inhibit or reduce microorganisms growth capacity on the surface of materials. In addition to this microbial proliferation inhibition, antimicrobial coatings may also confer additional properties. Researchers from the University of Alcalá and the CSIC Institute of Catalysis and Petrochemistry, have carried out a research about the self-cleaning properties of antimicrobial surfaces functionalized by photocatalytic ZnO electrosprayed coatings. The authors prepared electrosprayed photoactive coatings of sol-gel ZnO nanoparticles tested as dua[...] 31 May Researches of NANBIOSIS Unit 27 High Performance Computing, S. Kontaxis, J. Lázaro, E. Gil, P. Laguna, and R. Bailón are the authors of an article recently published by IEEE Transactions Biomedical Engineering Alternations of cardiorespiratory interactions are related to Autonomic Nervous System (ANS) dysfunction and physiological regulation of the Heart Rate Variability (HRV) in cardiovascular diseases. In this study, a method for assessing nonlinear cardiorespiratory interactions is proposed, quantifying the Quadratic Phase Coupling (QPC) between respiration and HRV. Quadratic cardiorespiratory couplings are studied during a tilt table test protocol on young healthy subjects. Results show a significant reduction of QPC[...] 30 May Next Thurstday, June 6th, the “Aragón Engineering Research Institute” (I3A) of University of Zaragoza will hold the “VIII Conference of Young Researchers” at the Conference Room Building. R & D (block 1, 1st floor) Researchers of NANBIOSIS unit U13 Tissue & Scaffold Characterization Unit will present their works In the oral presentations section, Mohamed H. Doweidar will talk about Cell behavior under hypoxic conditions. Computational 3D model. In the posters section in the area of BIOMEDICAL ENGINEERING the researchers of unit 13 will present the following results. Design of a microfluidics system for the simulation of the formation of atheromatous[...] 29 May Next June 11, 2019, from 09:30h to 17:00h, will take place in Eureka Building – Parc de Recerca, UAB (Barcelona), a Scientific-Theoretical / Practical Workshop on: DYNAMIC SORPTION OF VAPORS (DVS – DYNAMIC VAPOR SORPTION) AND CHARACTERIZATION OF MATERIALS (iGC / SEA – INVERSE GAS CHROMATOGRAPHY / SURFACE ENERGY ANALYZER) FOR THE ANALYSIS OF THE SORTION OF WATER AND ORGANIC VAPORS, AND CHARACTERIZATION OF MATERIALS AND SURFACES. The event is organized by IESMAT, S.A. in collaboration with Nanomol Technologies SL, the Institute of Materials Science of Barcelona (ICMAB-CSIC), Surface Measurement Systems (SMS) and the Center for Biomedical Research in Network[...] 24 May ATRIAL fibrillation (AF) is the most prevalent sustained arrhythmia and it has become one of the most important public health issues in developed countries. It is expected to double its incidence by 2030 [1], [2], representing the major cause of hospitalizations in elderlies (≥65 years), together with chronic heart failure Alba Martín-Yebra and Juan Pablo Martínez, scientists of NANBIOSIS U27 High Performance Computing, have led the research that proves that it is possible to stratity AF patients at risk of sudden cardiac death (SCD) what could help cardologists to implement better solutions. The computation was performed by the ICTS NANBIOSIS,[...] 23 May During the days 22-24 of May is taking place in Madrid the 3rd Workshop of introduction to the preclinical molecular image and its application to biomedical research,. The wokshop has been organized by the Health Research Institute of the Gregorio Marañón Hospital, the Complutense University of Madrid and the Madrilenian Network of nanomedicine in molecular imaging (RENIM-CM). The program counts with theoretical sessions of introduction to the physical foundations of each one of the modalities of image and its applications to preclinical biomedical research, as well as practical demonstrations of said image techniques. Ibane Abásolo, Scientific Coordinator of Unit 20[...] 22 May An Eskimo in the desert is the title of the talk that Ignacio Ochoa Researcher of NANBIOSIS U13 Tissue & Scaffold Characterization Unit is giving today at the Pint of Science Festival in Zaragoza at 19:00. One of the greatest advances in biomedicine was to achieve, at the end of the 19th century, maintain human cells outside the body in order to study them. This breakthrough has allowed us, for example, to discover new drugs and evaluate the toxicity of many compounds. Unfortunately, this progress has hardly evolved over these 125 years. However, the arrival of microfluidic technology has allowed[...] 21 May Francisco Miguel Sánchez Margallo, Scientific Director of the Minimally Invasive Surgery Center ‘Jesús Usón’ and Deputy Director of NANBIOSIS, leads, together with Thomas Malone, of the Massachusetts Institute of Technology (MIT), in the United States, the project selected by the MIT program -Spain ‘La Caixa’ Foundation Seed Fund “Developint a sensor framework for minimally invasive surgery”. The project seeks to develop a system of sensors to analyze health parameters of the surgeon, such as his physiological and ergonomic state, as well as the interaction between this and the patient during surgery. It is a disruptive research project on sensors to[...] 20 May Ana Paula Candiota, Scientific coordinator of U25 of NANBIOSIS, is the IP of the granted project Multiparametric MR approaches for non-invasive Glioblastoma therapy response follow-up (MAGRes), selected for funding in the ATTRACT call https://attract-eu.com/the-project/ The kick-off meeting for is taking place at CERN, Switzerland, days 20-21th May with talks of all selected projects. Unit 25 will have a relevant role in the development of MAGRes. MRI/MRSI from preclinical brain tumors will be acquired at NANBIOSIS U25, NMR: Biomedical Applications I[...] 17 May Scientist aiming at developing a career in project management is required for a European Project in the field of biomedical research; working with NANBIOSIS ICTS (Scientific infraestructure of CIBER-BBN). The position requires good command of English and strong skills in coordinating researchers. Applications must be filed at CIBER’s web portal untill May 22.[...] 16 May The Safe-N-MedTech European Project kcks off in Bibao to create an open innovation platform that accelerates the development of medical devices based on nanotechnologies. During 2 and 3 of May took place in Bilbao, at the University of the Basque Country, the kick off meeting of the European project Safe-N-Medtech organized by Osteba, the HTA Unit of the Ministry of Health of the Basque Country (Spain) in collaboration with BIOPRAXIS-BIOKERALTY. Safe-N-Medtech, counts with 28 partnerts coordinated by TECNAN (Navarran company with great experience in Nano products), together with BIOPRAXIS-BIOKERALTY, the research branch of the global health companies Keralty and Praxis.[...] 14 May The research carried out by the NanoBiocells group, coordinator of NANBIOSIS U10 Drug Formulation unit, from CIBER-BBN and UPV-EHU, with BIOMICS group of UPV-EHU was yesterday highlighted in Catalunya Vanguardista and Noticiasdelaciencia.com. The research reduces the volume of implantation of microcapsules containing insulin-producing pancreatic cells by almost 80% thanks to an innovative system of Magnetic separation of microcapsules. In this way, the medical complications derived from the implantation of large volumes of microcapsules decrease and the treatment of type 1 diabetes mellitus improves. More information: https://www.catalunyavanguardista.com/nuevo-sistema-para-el-tratamiento-de-diabetes-mellitus-tipo-1/[...] 13 May Researchers from the NanoBioCel and the ICTS NANBIOSIS through the Drug Formulation Unit 10 of CIBER-BBN and the University of the Basque Country (UPV/EHU), together with the University of Michigan (USA), have developed a biomedical cellular immunoisolation device (microcapsules) with intrinsic capacity to be traced once implanted in the organism. The novel design incorporates a natural substance called genipine, which emits intense and stable fluorescence in the far red range. Drug Formulation Unit 10 of Nanbiosis has worked in the design and development of fluorescent particles for use in experimental animals. Non-invasive monitoring of implanted hydrogel-based biosystems generally requires indirect[...] 08 May CIBER-BBN offer two possitions for a project manager (PRF-1768 https://www.ciberisciii.es/empleo/detalle-oferta?id=1768 ) and a researcher (PRF-1766 https://www.ciberisciii.es/empleo/detalle-oferta?id=1766) CIBER is looking for candidates for the selection of a project manager (https://www.ciberisciii.es/empleo/detalle-oferta?id=1768) and a researcher (ttps://www.ciberisciii.es/empleo/detalle-oferta?id=1766) to work in the framework of a European H2020 project. SAFE-N-MEDTECH is an Open-Innovation Test Bed for Safety Testing of Medical Technologies for Health – H2020 NMBP (Nanotechnologies, Advanced Materials, Biotechnology and Advanced Manufacturing and Processing) medtech project, that has just been launched. The project SAFE-N-MEDTECH will build an innovative open access platform providing reference laboratories and companies with the capabilities, know-how, networks and services needed for developing, testing, evaluating, optimizing and[...] 07 May The creation of a nanodrug capable of blocking the spread of the disease, which is known as metastasis, has been highlighted by Guia Medica, as a heavy blow struck against to colon cancer, the malignant tumor with the highest incidence in our country, a process that affects 40% of the million cases of this type of cancer that are diagnosed every year in the world, and that represents the main cause of death. The research, jointly carried out by scientists from the IIB Sant Pau, Sant Pau Hospital, the UAB, CSIC and CIBER-BBN, led by Esther Vázquez and Antonio Villaverde, Strategy[...] 06 May Next May 10, a conference on “Polymers and medical applications” will be held in Vizcaya, with the participation of NANBIOSIS Deputy Director, and JUMISC Scientific Director Dr. Francisco Miguel Sánchez Margallo, as guest speaker, who will give the lecture “Preclinical Research: Success Cases“ The event will count also with the expertise of Dr. Miguel Angel Martínez, Scientific Director of NANBIOSIS U13 Tissue & Scaffold Characterization Unit, talking about “Modeling and simulation in biomedical applications” Other topics that will be discussed at the Conference will be Hydrogels, Nanogels and Nanoparticles for Controlled Release of Bioactive Substances, The Microfluidics as a Tool for the Development of “Organ-on-a-chip and t[...] 30 Apr The 3D cross-correlation dynamic light scattering (DLS) spectrometer of NANBIOSIS U12 Nanostructured liquid characterization unit has been upgraded with a new goniometer and last generation laser detectors and beam splitters that allow to extend the scattering angle detection range to 10-150 degrees, and enables measurements in shorter scattering lengths for highly turbid and/or concentrated samples. Non-ergodic samples (e.g. gels) can also be measured with the new configuration The upgrade has been funded by CSIC through the grant “Special fund for the support of Scientific and Technical Services 2018” (02045)[...] 14 Apr Researchers of CCMIJU led by Verónica Crisóstomo, Scientific Director of NANBIOSIS U24 Medical imaging, and Javier García Casado Scientific Director of NANBIOSIS U14 Cell Therapy unit have carried out a study study aimed to identify which are the very early immune-related biomarkers that may be used as predictors of myocardial infarction severity. Experimental studies have been conducted by NANBIOSIS Units 14, 21, 22 and 24 of the CCMIJU, clinical test lab, animal housing, experimental operating room and medical imaging tecniciansare are recognized in the acknowledgement and funding sections of the article. Article of reference: Esther López, Francisco Miguel Sánchez-Margallo, Verónica Álvarez, Rebeca Blázquez, Federica Marinaro, Ana Abad,[...] 12 Apr The new Biolin Sigma 701 has replaced the previos KSV Sigma 700. in the equipment of NANBIOSIS U12 Nanostructured liquid characterization unit With this new tensiometer automated and high precision measurement of surface and interfacial tensions, contact angles and critical micelle concentrations will be obtained. The purchase of the new tensiometer has been co-funded by the CSIC through a grant received from the Scientific and Technical Services support (MEC1372).[...] 09 Apr NANBIOSIS ICTS coordination equipment has recently received from researchers of Human Molecular Genetics Group of Bellvitge Biomedical Research Institute (IDIBELL) a publication mentioning NANBIOSIS in the Acknowledgements for its participation in the results of its investigations. The article has been publish by the journal Human Reproduction of OXFORD UNIV PRESS with Quartile 1/ Decile 1. The study carried out by Maria Barcelo, Ana Mata, Lluís Bassas, and Sara Larriba demonstrates the potential of several miRNAs contained in small extracellular vesicles (sEVs) of seminal fluid as sensitive and specific biomarkers for selecting those azoospermic individuals with real chances of obtaining spermatozoa[...] 06 Apr Within the MOTHER project (Molecule-based materials and supramolecular organizations for therapy, diagnosis and tissue engineering), the NANOMOL group from ICMAB collaborates with the Vall d’Hebron Institute of Research (VHIR), on the developement of a new nanomedicine for the treatment of high risk neuroblastoma, one of the most typical childhood cancers. Now, researchers from VHIR have identified new microRNAs that reduce the progression of this type of cancer. The participation of NANOMOL group and NANBIOSIS unit 6 Biomaterial Processing and Nanostructuring Unit, as experts in nanoparticles and nanovesciles for nanomedicine, is on the synthesis of the adequate nanocapsules to protect, stabilize and direct this microRNAs molecules to t[...] 31 Mar Laura M. Lechuga, group leader of the CIBER-BBN at the Catalan Institute of Nanoscience and Nanotechnology (ICN2) and Sccientific Director of NANBIOSIS Unit 4 Biodeposotion Unit explains her research in an interview to CIBER Bulletin[...] 27 Mar Researchers of NANBIOSIS Unit 8 Micro and nano techonlogy unit, (Institut de Microelectrònica de Barcelona-CNM-CSIC/ CIBER-BBN ), led by Anton Guimera are coauthors of recently published article in the scientific magazine Nature Materials about the hidden brain activity, entitled “High-resolution mapping of infraslow cortical brain activity enabled by graphene microtransistors “ Recording infraslow brain signals (<0.1 Hz) with microelectrodes is severely hampered by current microelectrode materials, primarily due to limitations resulting from voltage drift and high electrode impedance. Hence, most recording systems include high-pass filters that solve saturation issues but come hand in hand with loss of physiological and pathological information. In this work, we use flexib[...] 21 Mar Unit 14 of Nanbiosis of Cell Therapy, led by Javier García Casado, has published a review on advances in the development of surgical meshes combined with stem cells. The work of the Nanbiosis team has been published in the prestigious journal “Acta Biomaterialia”[...] 15 Mar On March 11, the first meeting of the European project ABISens “Monitoring of Acquired Brain Injury and recovery biomarkers by the combined label-free nanoSensing of multiple circulating molecules” was held at the facilities of the Catalan Institute of Nanoscience and Nanotechnology ICN2. This new initiative aims to offer a new platform for photonic nanobiosensors that allows the identification and quantification of multiple brain biomarkers in blood with high sensitivity and in a short time. The new platform will use nanophotonic circuits in combination with the chemistry of oligonucleotides. Two units of NANBIOSIS participate in the project Unit 4 Biodeposition and[...] 13 Mar Researchers of NANBIOSIS U9 Synthesis of Nanoparticles Unit Manuel Arruebo and Víctor Sebastián have participated in a research published in the journal Nanomedicine Tuberculosis is an infectious disease that poses a serious public health problem and, according to WHO data, 10.4 million people became ill with tuberculosis and 1.7 million died in 2016. Therefore, advance in the development of new tools for diagnosis and treatment is essential and the use of nanoparticles could open a new horizon to deal with the infections caused by Mycobacterium tuberculosis. In this line, researchers from the CIBER at the University of Zaragoza, and at[...] 24 Feb Pilar Marco, Scientific Director of NANBIOSIS U2 Custom Antibody Service (CAbS) participated as Keynote speakers at the Second European Biosensor Symposium (EBS2019) taking about “Micro & nano(bio)technology for Diagnosis: Changes and Challenges” at the 2nd European Biosensor Symposium 2019 that took place in Florence (Italy) Last February 18-21. The EBS brougth toguether young scientists, experienced researchersand companies to push forward new approaches on biosensor and and their applications, Pilar Marco spoke abaut the changes ocurred on the field of Diagnosis since the days of “house calls”, relying primarily on physical examination, to nowadays in which a wide portfolio of biochemica[...] 20 Feb Jesús Usón Minimally Invasive Surgery Center (JUMISC), from Cáceres, partnert of NANBIOSIS, has recently made headlines on the website of the European Commission as an innovative center for Biomedical and Health Research. In the interview to his Director, Francisco Miguel Sanchez Margallo, he explained how European Funds allowed Infraestructures and Vanguard Technology for biomedical research at the CCMIJU, which have already been recognized, as part of NANBIOSIS, with CIBER-BBN and BIONAND, as “Singular Scientific and Technical Infrastructure” (ICTS). Complete news at European Commision’s Website: https://ec.europa.eu/spain/news/investeu_caceres_es https://ec.europa.eu/spain/news/investeu_caceres_es[...] 16 Feb Beatriz Moreno Lobato and Francisco Miguel Sánchez Margallo, Scientific Director and Coordinator of NANBIOSIS unit 19 Clinical tests lab at CCMIJU, have reclently published an study in the journal Thrombosis & Haemostasis: Research, with the aim to contribute with methodological results data to help the researcher to establish the validation of the analytical methods used within the research. Good Laboratory Practice (GLP) is a quality system of management controls to ensure the uniformity, consistency, reliability, reproducibility, quality, and integrity of pre-clinical safety tests. In the study, different hematological parameters (WBC, RBC, HB, HCT, MCV, MCH, MCHC, and PLT) were validated in pig,[...] 12 Feb Pilar Marco, Scientific Director of NANBIOSIS U2 Custom Antibody Service (CAbS) has been highlighted in the January Bulletin of CIBER-BBN ISCIII In the interview, among other topics Prof. Pilar Marco talks about diagnostic devices based on nanobiosensors and the extraordinary impact that these technologies could have on health in the coming decades. Her research group Nb4D (Nanobiotechnology for Diagnosis) has an important collection of specific antibodies for different biomarkers and the CIBER-BNN/IQAC-CSIS platform CAbS (Custom Antibody Service) that constitutes the unit 2 of NANBIOSIS, they offer the possibility of producing specific and immunoreactive antibodies with the necessary expertise to generat[...] 11 Feb Today February 11 is the International Day of Women and Girls in Science, a day to raise awareness of the gender gap in science and technology. According to the United Nations, while yet women and girls continue to be excluded from participating fully in science, science and gender equality are vital to achieve the internationally agreed development goals, including the 2030 Agenda for Sustainable Development. Thus, in recent years, the international community has made a great effort to inspire and promote the participation of women and girls in science. NANBIOSIS wants to acknowledge the efforts made by scientific women who struggle every day to contribut[...] 10 Feb Prof Laura Lechuga, Scientific Director of NANBIOSIS U4 Biodeposition and Biodetection Unit is coauthor of an article publish by ACS Sonsors that shows a portable and autonomous device based on optical interferometry that, when used with specialized nanoplasmonic, can detect directly bacterial cells of the patient’s blood plasma. The work demonstrates the potential of a microarray based POC device for bacteria quantification. The contribution of NANBIOSIS, in particular Unit 4, has been fundamental by providing the molecular printers necessary for the generation of the biofunctionalized specific microarrayed chips used for the bacteria detection. P. Dey, N. Fabri-Faja, O. Calvo-Lozano, R.[...] 09 Feb The 5th project face to face meeting has taken place in Cáceres (Spain). The first version of the PICCOLO prototype was set up at CCMIJU, facilities at the end of 2018, and it has been a great chance to show it to the PICCOLO consortium members. During these two days of the meeting, the technical partners presented both the individual components of the prototype (MPT and OCT) and the integration of the same in the probe of the multi-photonic system. The attendants have been able to check in-situ the performance of the prototype in the operating rooms of CCMIJU. Based[...] 06 Feb On January 23-24th a two-day meeting between NANBIOSIS and Stryker Trauma GmbH, took place at the Carlos III Health Institute, in Madrid, to explore synergies and potential joint initiatives. Nils Reimers and Robin Buescher from Stryker, presented some of their research and upcoming projects in the field of trauma medical devices, and representatives from NANBIOSIS’ units -Marisa González from U16 Surface Characterization and Calorimetry Unit, Teresa Galán from U7, Nanotechnology Unit, Gemma Pascual from U17 Confocal Microscopy Service, from CIBER-BBN, Marisa García from U28 (Bionand) and José Francisco Guillén and Francisco Sanchez Margallo from the units of the Jesús[...] 05 Feb ABISENS Monitoing of Acquired Brain Injury and recovery biomarkers by the combined label-free nanosensing of multiple circulating molecules is one of the project awarded in the EuroNanoMed III joint call, will be coordinated by Laura Lechuga through the CIBER-BBN Abisens will employ the Unit 4 of Nanbiosis, Biodeposition and Biodetection Unit or the multiplexed biofunctionalization of the biosensor chips and their methodology optimisation The evaluation of patients after brain injuries, which produces severe impairments, remains a major unmet clinical need. Nowadays the diagnosis, prognosis and the efficacy of rehabilitation treatments are mainly assessed by clinical examinations, neuroimaging and electrophysiological tests during a long hospitalization[...] 04 Feb The World Health Organization, the International Cancer Research Center (IARC) and the International Union Against Cancer (UICC) celebrate February 4 of each year as World Cancer Day Every year, 14 million new cases of cancer are diagnosed worldwide and the disease causes 8.2 million deaths. Thanks to scientific research, great advances have been made in the fight against cancer. Through surgery, chemotherapy or radio therapy and, in the last 20 years, through immunotherapy, hormonal treatment or cell therapies, tools have been obtained to improve early diagnosis and treatments, increasing cancer survival by 20%. The only way to understand cancer and,[...] 03 Feb A graphene implant that detects brain activity at extremely low frequencies could improve the technology of the electrodes to analyze the state of our brain, has been developed by researchers from several research institutes of the CSIC in Catalonia and the CIBER-BBN. Last First of February , Rosa Villa, Scientific Director of NANBIOSIS U8 Micro – Nano Technology Unit was interviewed in Ágora, a program of Scientific Dissemination of Radio Aragón. Dr. Villa, researcher of the Biomedical Applications Group of the Institute of Microelectronics of Barcelona and CIBER in Bioengineering, Biomaterials and Nanomedicine, explains the relevance of the research carried[...] 02 Feb Margarida Julià‐Sapé, Ana Paula Candiota and Carles Arús, Scientific Director and Scientific Coordinators of Nanbiosis U25 NMR: Biomedical Applications I, are the authors of a new article in the journal NMR in Biomedicine: “Cancer metabolism in a snapshot: MRS(I)” The article contains a revision of the contribution of MRS(I) to the in vivo evaluation of cancer‐metabolism‐derived metrics, mostly since 2016. Strategies include the following: (1) quantification of single oncometabolite content such as 2HG; (2) selected metabolite ratios such as total Cho to NAA in gliomas, ratios related to Cho, Cr, citrate and polyamines in prostate cancer or Lac/Pyr in hyperpolarized[...] 01 Feb The XXXVII edition of the Biennial Meeting of the Spanish Royal Society of Chemistry (RSEQ) will be held from the 26th to the 30th of May in Donostia-San Sebastian. Prof. Jaume Veciana, Scientific Director of NANBIOSIS and unit 06 of NANBIOSIS -ICTS Biomaterial Processing and Nanostructuring Unit, will present on May 28th 2019 a lecture entitled “Quatsomes. A new family of nanocarriers for drug delivery” at the Simposium “From Chemistry to Nanomedicine” (http://bienal2019.com/simposios.php). In this lecture the advantages and disavatages of such a kind of nanocarriers will be presentaed as well as some of their applications as nanomedicines.” Deadline for sending abstracts: January 30 (http://bienal2019.com/en/communications.php)&nbs[...] 29 Nov Researchers from NANBIOSIS units 2 and 4 have designed a biosensor device based on gold nanostructures that precisely detects the presence of the anticoagulant drug from a small blood sample. Treatments with anticoagulants such as Sintrom® (acenocoumarol) face the difficulty of adjusting the drug doses. This device will allow patients to self-regulate the dose. Researchers of NANBIOSIS unit 4 Biodeposition and Biodetection Unit of the Consejo Superior de Investigaciones Científicas (CSIC), the Catalan Institute of Nanoscience and Nanotechnology (ICN2) and CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) have developed a biosensor device which allows the monitoring of anticoagulants such as Sintrom® (acenocoumarol) to[...] 25 Nov The Diario Sur of Andalucía, publishes today an article dedicated to BIONAND and its recent accreditation as ICTS by the Ministry of Science, Innovation and Universities, that resolved on November 6 the incorporation of the Nanoimaging Unit of BIONAND to the ICTS NANBIOSIS. In the article, the Director of BIONAND, Jose Becerra Ratia, Professor of Cell Biology of the University of Malaga, explains the opportunities and commitments that imply for the Andalusian Center for Nanomedicine and Biotechnology (BIONAND) its incorporation to NANBIOSIS.[...] 24 Nov The project titled “Breaking the boundaries of resistance to antimicrobials; searching for new antimicrobials against multiresistant bacteria: work on polycytonic peptides and lipid nanoparticles (BARNAPA)” in which participates Fernando Albericio, Scientific Director of NANBIOSIS unit 3 Synthesis of Peptides Unit, has been selected by La Marató TV3 and finnaced with 383.276,25 €. According to Fernando Albericio, the project arises from the need of effective and safer antibiotics to fight resistant and multi-drug resistant bacteria. In this sens, the proyect developed in collaboration with Miquel Vinyas of the UB and with the Stefania Stefani group of the Universita de Catania looks at antimicrobia[...] 23 Nov La Marató TV3 in its call for biomedical projects in infectious diseases has selected the project “Uses of molecular analysis of Quorum Sensing with the diagnosis of bacterial infections” of the Nb4D group, led by Mª Pilar Marco, Scientific Director of unit 2 of NANBIOSIS and in which Miriam Royo also participates Scientific Coordinator of unit 3 of NANBIOSIS, both in the IQAC-CSIC of Barcelona The project of the Nanobiotechnology for Diagnosis (Nb4D) group of the CSIC and the CIBER-BBN has been selected among more than 200 candidates as a project of scientific excellence to be funded in the ca[...] 22 Nov Last November 19, Vall d’Hebron held a seminar on Lysosomal Rare Disorders: Focus on Fabry Disease as part of the Rare Diseases Program at the Vall d’Hebron Campus, in collaboration with the European Commission, the Center for Biomedical Research Network on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) and the CIBBIM-Nanomedicine at Vall d Hebron Research Institute (VHIR) through the Smart-4-Fabry projec In the second plenary session, moderated by Nora Ventosa and Simó Schwartz, Scientific Directors of NANBIOSIS units 6 and 20 and devoted to New therapeutic strategies for lysosomal disorders, the speakers presented their findings regarding biomarkers, genetic variants and treatment protocols.[...] 21 Nov The Scientific, Technological and Innovation Policy Council (CPCTI) of the Spanish Ministry of Science, Innovation and Universities has recently approved the updating of the National ICTS Map (Unique Scientific Technological Infrastructures). ICTS are large installations, resources, facilities and services, unique in its kind, that are dedicated to cutting edge and high-quality research and technological development, as well as to promote exchange, transmission and preservation of knowledge, technology transfer and innovation. After the evaluation by the CPCTI of the ICTS activity during the last four years, NANBIOSIS maintains its presence in the new National ICTS Map, but it introduces a novelty[...] 20 Nov NANBIOSIS has attended today the 10th Research and Innovation Framework under the slogan “Towards a New Horizon“, organized by the CDTI and the European Commission, in collaboration with the Board of Castilla La Mancha has been held on November 20 in the downtown Congress Center of Toledo “El Greco“. The objective of the Conference has been to review the new developments and analyze the participation of Spain in Horizon 2020 in order to draw conclusions that allow Spanish entities to better face the next calls for proposals. The new proposal of the European Commission (EC) for Horizon Europe has also[...] 19 Nov Members of the NANBIOSIS Coordination Committee have visited the ALBA Synchrotron and its representatives to exchange common research lines, points of view on their complementarity and discuss the collaboration possibilities of the facilities, both recognized as Unique Scientific Technical Infrastructure (ICTS) by the Spanish Government. The ALBA Synchrotron consists of a complex of electron accelerators in which the electrons are forced to rotate at a speed of 1 million turns per second. When they are bent, synchrotron light is emitted, allowing to visualize the atomic structure and molecular analysis of materials and study their properties obtaining information that cannot b[...] 16 Nov NANBIOSIS is one of the 29 ICTS (Unique Scientific Technological Infrastructures) recognized by the Scientific, Technological and Innovation Policy Council (CPCTI) of the Ministry of Science, Innovation and Universities. On November 6, the Council approved the updating of the ICTS Map in which the accreditation of Nanbiosis is renewed as one of them. The new Map is integrated by 29 ICTS, which bring together a total of 62 infrastructures, all of them operative. In the new update the number of ICTS is maintained, but the number of infrastructures is increased by the incorporation of new nodes to existing distributed ICTS.[...] 15 Nov Last 12 and 13 of November, CIBER-BBN has celebrated its 12th Annual Conference in Hotel Felipe IV in Valladolid. In poster session participated NANBIOSIS itself and some of its units. NANBIOSIS, Infrastructure for the Production & Characterization of Biomaterials, Nanomaterials and medical devices up to preclinical validation. Nanbiosis management team. Divalent cation effects on assembly of histidine-rich protein nanoparticles. López-Laguna, U. Unzueta, O. Conchillo-Solé, A. Sánchez-Chardi, M. Pesarrodona, O. Cano-Garrido, E. Voltà, L. Sánchez-García, N. Serna, P. Saccardo, R. Mangues, A. Villaverde, E. Vázquez (NBT-UAB) (U1 -U18) Antimicrobial peptides (AMPs) anchored on the surface of contact lenses to prevent corneal infections. Emiliano Salvagni, Clara García,[...] 13 Nov Marisa González, Scientific Director of NANBIOSIS Unit 16 Surface Characterization and Calorimetry Unit, runs for elections to the Rectorate of the University of Extremadura, to be held on November 27. Marisa González, Professor of Applied Physics in the Faculty of Sciences and the Group Leader of Microbial Adhesion research group of CIBER-BBN at University of Extremadura, she works with implants and materials on contact with body fluids and tissues, such as blood or bones, and the importance of knowing how these surfaces interact with proteins and molecules in the blood, and how they would do it in case of that bacteria could arrive that[...] 12 Nov CIBER-BBN Annual Conferences are taking place now in Hotel Felipe IV in Valladolid, 150 scientists in the field of nanotechnology, biomaterials and bioengineeering gather to share their progress during this year, present their projects and seek synergies for collaboration. The NANBIOSIS Session will take place this afternoon at 16:30, and at 18:30 will take place NANBIOSIS Scientificic Advisory Board meeting &nbs[...] 08 Nov NANBIOSIS, U20. In Vivo Experimental Platform, led by Dr. Simó Schwartz and Dr. Ibane Ibasolo, has been recently updated and improved as a result of its participation in the project FICTS1420-20, selected by the MICINN for co-financing by the FEDER Program in ICTS 2014-2020. These update and improvement include: DLS meassurement system, a fluorimeter and a waterbath for specific activity assays. The fine characterization of the size and size distribution of nanoparticles is essential for the right understanding of their in vivo behavior. The incorporation of this service to the U20 allows the determination of the drug/fluorophore loading/activity of the drug delivery systemistered in vivo, a good quality[...] 07 Nov At the beginning of June, the Jury of the Rei Jaume I 2018 Awards, formed by Nobel Prize winners, businessmen and scientists, met in Valencia to choose the winners. Today has taken place the ceremony of delivery of the 30th edition of the awards presided over by King Felipe VI. Among the six winners, in the category of New Technologies was Ramón Martínez Mañez, Scientific Director of the CIBER-BBN and Unit 26 of NANBIOSIS. Coinciding with its thirtieth anniversary, the Rei Jaume Foundation has produced a series of videos of interviews with the winners. In this video, Ramón Martínez Mañez,[...] 04 Nov Ana Paula Candiota and Carles Arús, Scientific Cordinator and Scientific Director of U25 of NANBIOSIS, NMR: Biomedical Applications I have participated in the research published by ACS Applied Materials & Interfaces Journal that include a preclinical study carried for brain Tumor. Extensive attention has been paid on designing and developing functional imaging contrast agents for providing accurate noninvasive evaluation of pathology in vivo. However, alse-positives or ambiguous imaging and the lack of a robust strategy for simultaneous dual-mode imaging remain to be fully addressed. One effective strategy for improving it is to design magnetic resonance imaging (MRI) contrast agents (CAs) wit[...] 03 Nov Researchers of NANBIOSIS Units at CCMIJU have publish a very relevant article about the studies on hematological, biochemical and immunological parameters, as well as magnetic resonance derived cardiac function measurements obtained from a swine myocardial infarction model that allows to predict the severity of myocardial infarction in a clinically relevant animal model providing a simple, affordable and reliable way that could prove useful in the follow up of myocardial infarction and in the evaluation of new therapeutic strategies in this animal model. Biochemical and hematological determinations were performed by the ICTS Nanbiosis (Unit 19. Clinical test lab at CCMIJU). Flow cytometry analyses were performed by the ICTS Nanbiosis[...] 01 Nov Ramón Martínez Mañez, Scientific Director of Unit 26 of NANBIOSIS NMR: Biomedical Applications II, will be next Monday, November 5 at 7 pm at the Headquarters of Alicante City (San Fernando, 40), where he will impart the conference “The scientific revolution of Nanomedicine,” The professor of Inorganic Chemistry of the UA and director of the Nanotechnology laboratory, Javier García Martínez, will present the meeting, organized by the Fundación Premios Rey Jaume I and the UA, with the collaboration of the Valencian Agency and Innovation and the Classroom of Science and the Technology of the University of Alicante. Ramón Martínez-Máñez, director of[...] 31 Oct FUNCATH project, coordinated by scientists of NANOMOL group, led by Dr. Imma Ratera, has been awarded by Fundació La Marató de TV3 . NANOMOL is the research group that coordinates NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit, from ICMAB-CSIC and CIBER-BBN. Fundació La Marató de TV3 2017 call was dedicated to infectious diseases and awarded 36 projects among the 186 evaluated according to their excellence, methodology and relevance. FUNCATH is the project for Prevention of infections related to vascular catheters by functionalizing catheters impregnated with thermically activatable hydrogels with broad spectrum antimicrobial agents, whose ultimate goal is the development of vascular catheters coated with multibiofunctiona[...] 24 Oct Next November 14 the General Assembly of Materplat 2018 will take place in the facilities of the Institute of Ceramics and Glass of the CSIC (ICV-CSIC), on the campus of the Autonomous University of Madrid (Cantoblanco, Madrid). This year, the theme of the Assembly will be focused on how innovation in materials that can be useful in different fields related to smart cities. In this sense, different speakers will show developments in materials very important for sectors such as health, among others. NANBIOSIS will be present through José Becerra, Professor of Cell Biology at the University of Málaga, Scientific Director[...] 15 Oct NANBIOSIS has participated in the most important event of the pharmaceutical industry, CPhI Worldwide, the largest fair held in Spain. More than 45,000 professionals from more than 150 countries of the main companies in the sector and more than 2,500 companies meet at IFEMA (Madrid) from 9 to 11 October. One of the novelties to be taken into account in this edition of the CPhI Worldwide will be the presentation of biological products by the bioLIVE platform, highlighting the recent growth of biological medicines. BioLIVE, adjacent to CPhI Worldwide in 2018, is the exhibition and conference for large molecule biopharma needs.[...] 11 Oct The Unit 6 of NANBIOSIS, Biomaterial Processing and Nanostructuring Unit, has organized during the days 8 to 11 of October in the ICMAB-CSIC a course of characterization of Nanoparticles showing some of their techniques to the CSIC researchers. Amable Bernabé, the technician of unit 6 of NANBIOSIS has shown the theory and practice of some methods to characterize nanoparticles and how to handle the necessary equipment. Specifically, these techniques were: Dynamic Light Scattering (DLS) with Zetasizer Nano ZS (Malvern Instruments) Size distribution Z Potential Nanoparticle Tracking Analysis (NTA) with Nanosight NS300 (Malvern Instruments) Size distribution Particle concentration Fluorescence Light Scattering (LS) with Mastersizer 2000 (Malvern[...] 09 Oct Researchers Manuel Arruebo and Víctor Sebastián, from the CIBER-BBN group led by Jesús Santamaría (NFP) at the University of Zaragoza, that coordinates NANBIOSIS Unit 9 Synthesis of Nanoparticles, have received the second prize of the Resomer Awards granted by the company Evonik, a international recognition to competitiviness. Their work “Promoting bioengineered tooth innervation using nanostructured and hybrid scaffolds”, has been published in the journal Acta Biomaterialia 50 (2017) 493-501. In this work, the researchers of the CIBER-BBN manufactured biodegradable materials such as scaffolds to promote dental regeneration. These scaffolds contained an immunosuppressive drug that, in addition to avoiding rejection after implantation,[...] 05 Oct On September 25, the Polytechnic University of Valencia hosted the Solemn Act of the new Academic Opening year 2018-2019 of Spanish universities, coinciding with the commemoration of its 50th anniversary. This institutional act was chaired by S.M. King Felipe VI, the Minister of Science, Innovation and Universities, Pedro Duque, and the President of the Generalitat Valenciana, Ximo Puig, among many other authorities. Ramón Martínez Máñez, has been in charge of teaching the master class of the new academic year. Ramón Martínez is professor of the Department of Chemistry of the UPV and director of the Interuniversity Research Institute of Molecular[...] 27 Sep NANBIOSIS participates in BioSpain 2018, which is taking place in this ninth edition, in Seville, on September 25-27. BioSpain is one of the main fairs of the European biotechnology sector. It is an event, organized by the Spanish Association of Biocompanies (ASEBIO) in collaboration with Andalusian government which aims to exchange knowledge, ideas and experiences among all actors in the biotechnology sector. In this edition BioSpain has gathered more than 1,500 attendees, 600 companies and 200 stands. BioSpain is structured in a trade fair, a partnering system that facilitates these meetings, a conference program and an investor’s forum that brings together the most[...] 26 Sep The research group of Biomaterials for regenerative therapies of CIBER-BBN and IBEC, coordinator of Unit 5 of NANBIOSIS, Rapid Prototyping Unit, led by Elisabeth Engel, expert on nanoparticles and biomaterials, together with the company Avinent, expert in 3D printing, will develop new personalized solutions to improve treatments for bone diseases or injury. So far, they have tested some bioactive nanoparticles based on calcium on the membrane of a chicken embryo and found that blood vessels formed in it and that the cartilage ossified forming a mature bone. The tests were carried out in mice and the result was also positive. The creators[...] 25 Sep NANBIOSIS Unit 17 Confocal Microscopy Service, has participated in the research results published by Science of the Total Environment in an article titled “Recycled desalination membranes as support material for biofilm development: A new approach for microcystin removal during water treatment”. The biofilm visualization has been performed by ICTS “NANBIOSIS” For further information: doi.org/10.1016/j.scitotenv.2018.07.435 &nbs[...] 24 Sep CIBER-BBN will celebrate its 12th Annual Conference on November 12 and 13 in Vlladolid. In these conference there will be a session dedicated to NANBIOSIS. Likewise, the annual meeting of the Scientific Technical Advisory Committee of NANBIOSIS will take place. As in previous occasions, the meeting will serve to know the activity of NANBIOSIS, the Singular Technical Scientific Infrastructure (ICTS) of the CIBER-BBN and the Minimally Invasive Surgery Center Jesus Usón for the production and characterization of biomaterials, nanomaterials and devices up to its preclinical validation. The new Cutting-edge Biomedical Solutions of NANBIOSIS wiil be presented.[...] 17 Sep Prof. Jaume Veciana, Scientific Director of NANBIOSIS has been honored with the Olivier Kahn Plenary Lecture given at the 16th International Conference on Molecule-Based Magnets (ICMM 2018), held on September 1-5, 2018, in Rio de Janeiro, Brazil. For further information: click her[...] 14 Sep Prof Laura Lechuga, Scientific Director of NANBIOSIS Unit 4 Biodeposition and Biodetection Unit, has led the research whose results have been published by Biosensors and Bioelectronics with the title “Label-free DNA-methylation detection by direct ds-DNA fragment screening using poly-purine hairpins” Cancer diagnosis continuously evolves due to the better understanding of tumorigenic processes. DNA-methylation is consolidated as an effective biomarker for cancer prognosis and diagnostic even in tumors of unknown origin. The reversibility of this epigenetic mechanism also places it as a high-profile tool for the development of more sophisticated and personalized therapies. Current methodologies, such as bisulfite conversion or PCR amplification, rely on complex[...] 07 Sep Dr. Francisco Miguel Sánchez Margallo, Assistant Director of NANBIOSIS and Scientific Director of JUMISC, has attended the multidisciplinary Congress organized by the Society of Laparoendoscopic Surgeons (SLS), held in New York from August 29 to September 1, where he has presented scientific communications with very innovative results in the specialty of urology. At the annual meeting of this Scientific Society, international specialists related to minimally invasive surgery meet, with the aim of increasing knowledge of laparoscopic, endoscopic and minimally invasive surgical techniques, including robotic surgery. The papers presented by Dr. Francisco M. Sánchez Margallo, have received the Harrith M. Hasson[...] 06 Sep Researchers of NANBIOSIS U18 Nanotoxicology Unit and U1. Protein Production Platform (PPP) at the Biomedical Research Institute of Sant Pau (IIB Sant Pau), of the Hospital of Santa Creu i Sant Pau, of the Universitat Autònoma de Barcelona (UAB), the Superior Council of Scientific Research (CSIC) and the Center for Biomedical Research in Network (CIBER) have published an article in one of the most prestigious international scientific journals in the field of Molecular Medicine, EMBO Molecular Medicine. This article demonstrates the efficacy of the nanopharmaceutical that selectively removes metastatic stem cells in animal models of colon cancer. The new drug works like a[...] 05 Sep The VPH Conference 2018 is taking place in Zaragoza 5-7 September offering an exciting program of state-of-the art science & engineering in computational (bio)medicine, ranging from foundational research on multiscale modelling of human (patho) physiology, via underpinning research on data science and infrastructures for the virtual physiological human, to clinical applications with participation of NANBIOSIS U27. High Performance Computing Esther Pueyo is charing the Session 3A: Cardiovascular modeling: from simulation to clinical outcome, Some of the outcomes are presented by Jesús Fernández-Bes: A Bayesian Filtering methodology to identify key drivers of ventricular repolarization variability (Jesus Fernandez-Bes, David Adolfo Sampedro-Puente and Esther Pueyo) Virtual Physiologica[...] 04 Sep As a result of the collaboration carried aout by two units of NANBIOSIS, U4. Biodeposition and Biodetection Unit and U2. Custom Antibody Service (CAbS), it has been developed a compact and simple nanoplasmonic sensing device based on gold nanodisks for the rapid monitoring of acenocoumarol, using highly specific polyclonal antibodies produced against the drug Acenocoumarol (Sintrom®) which implies: A label-free nanoplasmonic device for the rapid monitoring of acenocoumarol in plasmaD. Direct quantification in real time requiring low sample volume is achieved. Non-specific interferences from plasma are minimized using the developed methodology. Excellent accuracy has been observed measuring blind plasma samples. Potential to be implemented as a POC devic[...] 29 Aug On November 2th-30th, Centro de Cirugía de Mínima Invasión Jesús Usón, partner of NANBIOSIS, organizes a theorical and practical course: “Course for the performance of functions a, b and c in rodents, lagomorfos, carnivores, pigs and small ruminants”. Some researchers of NANBIOSIS Units at JUMISC, will transmit their knowhow and experience to the attendees. The course objetives are to provide adequate training to researchers in the science and welfare of the laboratory animal, as well as the use of bloodless methods of euthanasia that will be carried out with experimental animals in accordance with current legislation and existing recommendations. This course, onc[...] 27 Aug On October 24th-26th, Aula Científica, in collaboration with IBB, organizes a theorical and practical course on “Recombinant proteins production: optimization strategies“. Some researchers of NANBIOSIS Unit1 Protein Production Platform (PPP), will transmit their knowhow and experience to the attendees, as José Luis Corchero, Rosa Mendoza Moreno and Neus Ferrer Miralles, Scientific Director of the Protein production planform of ICTS NANBIOSIS. The course is aimed at researchers and laboratory technicians from universities, hospitals, companies and research centers who are interested in the expression, production and purification of recombinant proteins with de objectives of analyze and design strategies for the improvement in the expression,[...] 25 Aug Nathaly Segovia, Scientific coordinator of NANBIOSIS U 6, Biomaterial Processing and naostructuring unit, explains in this video what the objective of her unit , the services they offer and their technologies in the field of drug delivery.[...] 24 Aug Miriam Royo, Scientific Coordinator of Unit 3 of NANBIOSIS explains in this video the expertise of the unit in the preparation of difficult peptides (Cyclid and polycyclic peptides, stapled peptides and dificult peptides, depsipetides, natural products and libraries, peptidomimetic libraries, peptides as antigens or adjuvants, tarjeted drug conjugates, etc… as well as therapeutic agen-PEG-targeting unit conjugates[...] 23 Aug Victor Sebastian, researcher of NANBIOSIS Unit 9 Synthesis of Nanoparticles Unit, explains the production technologies in continuous (Microfluidic systems liquid phase or pyrolysis activated by laser, gas phase in which the nanoparticles are produced)[...] 22 Aug José Luis Pedraz, Scientific Director of NANBIOSIS Unit 10, Drug formulation, talks in this video about Micro and polymeric nanoparticles, lipid nanoparticles, non-viral vectors for gene therapy and scaffolds for cell therapy and regenerative medicine and bio 3D printing &nbs[...] 20 Aug Ramón Mangues, Scientific Dierctor of unit 18 of NANBIOSIS, Unit of nanotoxicology, explains in this video some of the animal models used in the unit for preclinical validation of nanoparticles, especially of application in cancer[...] 17 Aug Ibane Abásolo, Scientific Coordinator of NANBIOSIS U20, explains in this video the studies of biodistribution, safety and efficacy of nanotechnological systems of pharmacological liberation that are developed in this unit and , overall, their expertise and differentiation in the sector in the evaluation of nanosystems (with certification ISO 901-2015)[...] 16 Aug In this video, Beatriz Moreno Lobato, Head of Unit 19 of NANBIOSIS, Clinical Tests Lab and head of the Animal Modeling Service and Clinical Analysis Laboratory of CCMIJU, gives a talk about the use of Nanomedicine in preclinical studies and animal models. Models of type I and II diabetes, cutaneous ulcer models, animal models in ophthalmology, urology models, cartilage defect models or bone defects models and cardiovascular models such as mycardial infarction in pig that Beatriz explains in more detail, as well as implantation of surgical material in combination with adult stem cells[...] 14 Aug En este vídeo Jose Francisco Guillen Caro, Responsable de garantía de calidad del CCMIJU presents the Jesús Usón Minimum Invasion Surgery Center in Cáceres and, especially, the UMISC units that integrate NANBIOSIS, as well as the services and tests they perform, which are certified as GLP[...] 13 Aug In this video, Jesús Izco Ex. Director of NANBIOSIS, presents NANBIOSIS as one of the 29 ICTS that currently make up the national ICTS map. It consist consists of 27 units grouped into five platforms which ofer their services under a single contact point and develops on demand projects and cutting edge biomedical solutions in different biomedical applications such as biosensors, live image, contrast agents, therapeutic agents, regenerative medicine, drug delivery, among others. &nbs[...] 10 Aug NANBIOSIS makes available its youtube channel with informative videos about the ICTS-NANBIOSIS and the activity of some of its research units and platforms, as well as its Cutting-edge Biomedical Solutions and Nanomedicines Cascade Characterizations NANBIOSIS youtub[...] 09 Aug Jaume Veciana and Imma Ratera (NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit) have supervised Manuel Souto’s PhD thesis entitled “Multifunctional Materials based on TTF-PTM dyads: towards new Molecular Switches, Conductors and Rectifiers”. The School for Doctoral Studies, together with UAB Alumni, organises an event every semester for the award of PhD degrees and PhD special prizes. With 66 PhD programmes, the UAB is one of the leading Catalan universities in the production of theses and generates approximately a third of the doctoral theses that are defended in the Catalan university system each year. The PhD special prizes confer value to theses which have received the qualification of excellenc[...] 08 Aug Researchers of NANBIOSIS U7 Nanotechnology Unit are coauthors of the article “Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons” by Molecular Neurobiology The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of β-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. Results demonstrate that Prnp expression is not mandatory for α-synuclein spreading. However, although the pathological spreading of α-synuclein can take place in the absence of Prnp, α-synuclein expanded faster in PrPC-overexpressing mice. In addition, α-synuclein[...] 06 Aug Researchers of NANBIOSIS U1. Protein Production Platform (PPP), organize a course on production of recombinant proteins together with Aula Científica whose objective is to analyze and design strategies for the improvement in the expression, production and purification of recombinant proteins in heterologous systems. For further information[...] 03 Aug Researchers of NANBIOSIS U7. Nanotechnology Unit, are coauthors of the article “Nanopatterns of Surface-Bound EphrinB1 Produce Multivalent Ligand–Receptor Interactions That Tune EphB2 Receptor Clustering” published by NanoLetters, ACC Publications. The authors present a nanostructured surface able to produce multivalent interactions between surface-bound ephrinB1 ligands and membrane EphB2 receptors. They have created ephrinB1 nanopatterns of regular size (<30 nm in diameter) by using self-assembled diblock copolymers. Next, they have used a statistically enhanced version of the Number and Brightness technique, which can discriminate—with molecular sensitivity—the oligomeric states of diffusive species to quantitatively track the EphB2 receptor oligomerization process in real time. The results[...] 02 Aug From the JUMISC, partner of NANBIOSIS it is been organized: the first edition of the “COURSE FOR THE PERFORMANCE OF FUNCTIONS A, B AND C IN RODENTS, LAGOMORFOS, CARNIVORES, PIGS AND SMALL RUMINANTS”. This course has the following characteristics: • Total duration: 98.5 hours, from November 2 to November 30, 2018, with a semi-face-to-face format and mandatory face-to-face practices on November 26, 27 and 28, 2018. • Cost: € 300 • 25 Places by strict order of registration. The course is already authorized by the Rural Environment Training Service of the Junta de Extremadura. In addition, accreditation has been requested by[...] 01 Aug The PRONANBIOSIS II Network of Excellence ICTS 2017 SAF2017-90810-REDI, granted by the Spanish Minitry of Science to NANBIOSIS, begins its activity planned for two years. Networks of Excellence favor the development of networks of research groups aimed, in this case, to promote the general coordination of ICTS or Distributed ICTS, as is the case of NANBIOSIS. This Network will give continuity to the previous PRONANBIOSIS Network, which ended on July 31st. The main purposes of the Network are: – to consolidate its unified management model, – to boost its internationalization and strategic positioning – to promote a complete cascade service for nanomaterials[...] 31 Jul Researchers of NANBIOSIS U12. Nanostructured liquid characterization unit, organize a course on advanced encapsulation technologies together with the Consorci Universitat Internacional Menéndez Pelayo Barcelona (CUIMPB) – Center Ernest Lluch whose objective is to provide attendees with the basic concepts about micro and nanoencapsulation techniques,including fundamentals and methods of preparation, as well as new applications in the chemical, cosmetic and pharmaceutical fields, among others. For further information and program[...] 30 Jul Scientists of NANBIOSIS U6. Biomaterial Processing and Nanostructuring Unit, have recently pubished an article in the ACS Omega about the design 0f 3D platforms specific for T cell culture to improve the current T cell expansion systems to introduce new in vitro models and facilitate the broad use of ACT in the clinics. Adoptive cell therapy, i.e., the extraction, manipulation, and administration of ex vivo generated autologous T cells to patients, is an emerging alternative to regular procedures in cancer treatment. Nevertheless, these personalized treatments require laborious and expensive laboratory procedures that should be alleviated to enable their incorporation into the clinics. With the objectiv[...] 27 Jul Senescent cells are damaged cells that do not perform their normal roles anymore but that are not dead –hence they are commonly known as zombi cells. These cells interfere with the functioning of the tissue in which they accumulate. Senescence is a cell program that is triggered by many types of damage and senescent cells are present in many diseases. They accumulate in diverse types of tissues during aging, thus contributing to the progressive deterioration associated to aging. Eliminating these zombi cells is one of the challenges facing science today. In the Cellular Plasticity and Disease lab headed by the ICREA researcher Manuel Serrano at[...] 26 Jul Spanish Goverment has granted a “Network of Excellence”: ICTS 2017 SAF2017-90810-REDI”, with the maximum funding of 89,700 euro to consolidate the unified management model of NANBIOSIS, to boost its internationalization and strategic positioning as well as to promote a complete cascade service for nanomaterials characterization. The two years lasting project has been granted within the frame of the National Programme for Fostering Excellence in Scientific and Technical Research. This Excellence project, funded by the Spanish Ministry of Economy and Competitiveness, will consolidate and promote the One Stop Shop model of NANBIOSIS, which facilitate to public and private centers of research and companies[...] 25 Jul Scientists of Unit 8 of NANBIOSIS are co-authors of the article “Resemblance of the human liver sinusoid in a fluidic device with biomedical and pharmaceutical applications“, recently published by Biotechnology and Bioengineering. The fabrication of Exoliver was performed by the platform of Production of Biomaterials and Biomolecules of the ICTS, more specifically by the “NANBIOSIS,” Unit 8. Maintenance of the complex phenotype of primary hepatocytes in vitro represents a limitation for developing liver support systems and reliable tools for biomedical research and drug screening. We herein aimed at developing a biosystem able to preserve human and rodent hepatocytes phenotype in vitro based on t[...] 24 Jul The general consul of France in Barcelona, Mr. Cyril Piquemal visited the IBB UAB facilities last July 18, to find out about the research that is being carried out and, in particular, explore possible collaborations in nano-pharmacy development projects. During the visit, the Consul of France in Barcelona was received by Màrius Martínez, Vice President of International Relations at the UAB; Maite Paramio, Deputy Vice President; Ivan Martínez, vice president of Research; Salvador Ventura, director of the Institute of Biotechnology and Biomedicine, and Antonio Villaverde, head of the IBB Nanotechnology Unit-NANBIOSIS U1. Protein Production Platform (PPP) Next, the mayor visited[...] 23 Jul As a result of a collaboration in the context of the EC-FP7 program OCEAN 2013, NANBIOSIS Unit 2 Custom Antibody Service (CAbS) and Unit 4. Biodeposition and Biodetection, the research groups coordinating this NANBIOSIS Units have recently published an article titled “Interferometric nanoimmunosensor for label-free and real-time monitoring of Irgarol 1051 in seawater” in the scientific magzine iosensors and Bioelectronics. The CIBER-BBN-ICN2 group Nanobiosensors and Bioanalytical Applications, led by Prof. Laura Lechuga has developed the immunosensor that is described in the article using immunoreactive, produced in the group of Nanobiotechnology for Diagnostics Group (Nb4D), led by Prof. Pilar Marco, with the collaboration of CAbS,[...] 22 Jul Nanoligent, S.L., the company stablished on March 2017 by professors Dr. A. Villaverde and Dra. E. Vázquez from NANBIOSIS Unit 1, professor Dr. M. Mangués from NANBIOSIS Unit 18, and entrepreneur Dr. M. Rodríguez is highlighted in la Vanguardia. More information here &nbs[...] 18 Jul Beatriz Macías García, researcher at NANBIOSIS U23. Assisted Reproduction, is co-author of the article “Seminal plasma influences the fertilizing potential of cryopreserved stallion sperm”, publish by the Journal Theriogenology. Seminal plasma (SP) contains proteins that may influence cryosurvival and prevent capacitation-like changes due to freezing and thawing. The objective of this study was to investigate the effect of adding pooled SP from “good” (GF) or “bad” (BF) freezer stallions on sperm cells’ fertilizing ability. “Good freezers” refers to stallions that usually produce ejaculates which can withstand cryopreservation, whilst “bad freezer” stallions produce ejaculates which cannot tolerate the freezing process. A heterologous zona binding assay with in vitro matured[...] 17 Jul Scientists of NANBIOSIS in the University of Zaragoza participated in the assembly held las week that put on the table the risks of applying rules in an incoherent way and without taking into account the reality of the work that researchers develop. The Spanish public contrat law prevents the University to spend more than 15,000 euros per provider per year, which complicates the purchases of material. The scientists ask that this legislation not be applied More than three hundred researchers have signed a manifesto in which they denounce that some provisions of the new Spanish law on public contracts prevent them[...] 16 Jul Laura Lechuga, Scientific Director of NANBIOSIS U4. Biodeposition and Biodetection Unit is coathor of the article “Gold/Silver/Gold Trilayer Films On Nanostructured Polycarbonate Substrates For Direct And Label‐Free Nanoplasmonic Biosensing” published by Ultrasmooth gold/silver/gold trilayer nanostructured plasmonic sensors were obtained using commercial Blu-ray optical discs as nanoslits-based flexible polymer substrates. A thin gold film was used as an adhesion and nucleation layer to improve the chemical stability and reduce the surface roughness of the overlying silver film, without increasing ohmic plasmon losses. The structures were physically and optically characterized and compared with nanostructures of single gold layer. Ultrasmooth and chemically stable trilayer nanostructures with a surface roughness <0.5 nm[...] 15 Jul Francisco M. Sánchez-Margallo, Assistant Director of NANBIOSIS and Scientific Coordinator o NANBIOSIS U23. Assisted Reproduction, is co-author of the article “Mimicking physiological O2 tension in the female reproductive tract improves assisted reproduction outcomes in pig”, publish by the Journal Molecular human reproduction The research has been carried out with the participation of the NANBIOSIS Assisted Reproduction Lab that has a 120 m2 laboratory, small animal surgery, clinical analysis support, etc. and it is featured with two intracitoplasmatic micromanipulation equipment of the latest generation with IMSI, Laser and Oosight system, embryo biopsy systems, vision systems of the mitotic spindle, with flow cabinets with stereo-microscopes and heated plates, incubators[...] 13 Jul The Spanish Society of Numerical Methods in Engineering (SEMNI) has awarded the SEMNI O. C. Zienkiewicz prize to Professor Dr. Manuel Doblaré. The SEMNI O. C. Zienkiewicz Award is the highest award given by this company and recognizes, in this case, both the undisputed scientific curriculum of prof. Doblaré as his permanent contribution to the good functioning of this society, of which he has been a founding member and member of its executive committee until 2007, having also organized the Congress of Numerical Methods in Zaragoza in 1996. The prize will be given during the Congress of Numerical Methods to[...] 12 Jul During two days meeting, the PICCOLO consortium 4th face to face meeting has taken place. Project partners reviewed the current state of the development, results, deliverables and future actions. Inspired in the experimental setting up of the JUMISC, one of the most interesting topics in this meeting was the pre-clinical discussion about the validation plan of the PICCOLO prototypes. The PICCOLO consortium analysed both laboratory and pre-clinical trials that will start at the end of this year. Some detailed protocols and preliminary results of the experimental models for these trials were presented as results of a close collaboration between clinical and technological partners. It has been a great[...] 11 Jul Jesús Santamaría, Scientific Director of NANBIOSIS Unit 9, Synthesis of Nanoparticles Unit, denounces the bureaucratic obstacles of the Law of Contracts, which are paralyzing the investigations whenever it is necessary to buy material or hire personnel. His research against cancer, which received one of the most powerful European funding of more than two million euros, is stranded because of this rule, which requires to take out any purchase over 15,000 euros. “You can not do research like that,” Santamaría said. “In other countries there are no obstacles and we have to compete with them” With the entry into force on March 9 of[...] 10 Jul Scientists of the CIBER-BBN and IBEC reserch group Biomaterials for Regenerative Therapies, led by Miguel Angel Mateos-Timoneda and Elisabeth Engel who run NANBIOSIS U5. Rapid Prototyping Unit, have published a review of the state-of-the-art in biomaterials for skin healing that proposes a move towards more personalized, in situ therapies. Skin wound healing repairs and restore tissue through a complex process that involves different cells and signalling molecules that regulate cellular response and the remodelling of the extracellular matrix. Publishing in Advanced Drug Delivery Reviews, the article begins by summarizing recent advances in therapies for healing that combine biomolecule signals such as growth factors and cytokines wit[...] 09 Jul Dr. Javier García Casado, Scientific Director of NANBIOSIS Unit 14, of Cell Therapy, has been awarded by the General Secretariat of Science, Technology and Innovation, belonging to the Ministry of Economy and Infrastructure of the Autonomous Community of Extremadura, the accreditation of research excellence of the Autonomous Community of Extremadura in the field of Life Sciences, which includes the research areas of Cellular and Molecular Biology, Medical Sciences, Pharmacology and Physiology, Food Science and Technology and other related fields. The accreditation, which is valid for 4 years, is the recognition of Javier García Casado’s research career, highlighted by his contributions[...] 08 Jul Scientists of NANBIOSIS Unit 9 Synthesis of Nanoparticles Unit are coauthors of of the New cover ACS Sustainable Chem. Eng. Sustainable Production of Drug-Loaded Particles by Membrane Emulsification. Albisa A, Piacentini E, Arruebo M, Sebastian V, Giorno L. ACS Sustainable Chem. Eng., 2018, 6 (5), pp 6663–6674 March 13, 2018. DOI: 10.1021/acssuschemeng.8b00401. IF: 5,951[...] 07 Jul NANBIOSIS Unit 6 Biomaterial Processing and Nanostructuring and Unit 3 Synthesis of Peptides collaborate in a research whose results are published by The Journal of Physical Chemistry B Stimuli-Responsive Functionalization Strategies to Spatially and Temporally Control Surface Properties: Michael vs Diels–Alder Type Additions Adriana R. Kyvik, Carlos Luque-Corredera, Daniel Pulido, Miriam Royo, Jaume Veciana, Judith Guasch, and Imma Ratera The Journal of Physical Chemistry B 2018 122 (16), 4481-4490 DOI: 10.1021/acs.jpcb.8b01652 Stimuli-responsive self-assembled monolayers (SAMs) are used to confer switchable physical, chemical, or biological properties to surfaces through the application of external stimuli. To obtain spatially and temporally tunable surfaces, we present microcontact printed SAMs of a hydroquinone molecule that are used[...] 06 Jul Last month NANBIOSIS Unit 7 Nanotechnology Unit Scientific Director Josep Samitier was one of the panelists in a round table organised by the Cercle de Salut, an association devoted to improving the health system so that it may respond adequately to the challenges posed by society. In the discussion at the Parc de Recerca Biomèdica de Barcelona (PRBB) entitled ‘L’excel·lència en la recerca, reptes immediats’, Josep and the other participants – ISGlobal director Antoni Plasencia and IrsiCaixa director Bonaventura Clotet – discussed the current situation of biomedical research in Catalonia. In particular, the hot topic under discussion was the impact that recent[...] 05 Jul Judith Guasch holds a senior postdoctoral research position at the NANOMOL group CIBER-BBN at ICMAB-CSIC that coordinates NANBIOSIS Unit 6 Biomaterial Processing and Nanostructuring Unit, after being awarded with a TecnioSpring fellowship (Marie Curie Fellow, Cofund – Catalan Government and EU). Since 2017 she is also head of a Max Planck Partner Group (Dynamic Biomimetics for Cancer Immunotherapy) in collaboration with the Max Planck Institute for Medical Research (Heidelberg, Germany). Judith’s research interests are focused on the design, synthesis, and fabrication of multifunctional molecular and supramolecular materials for biomedical applications. Special interest is devoted to study the cell-material interaction for improving novel adoptive cell therapies for the treatment of cancer.[...] 04 Jul Josep Samitier, Scientific Director of NANBIOSIS Unit 7 Nanotechnology Unit, has been highlighted in ‘Dominical’ supplement of the Diari de Girona last week. More information here [...] 03 Jul Francisco M. Sánchez-Margallo, Assistant Director of NANBIOSIS and Scientific Director of JUMISC is co-author of the article “Parasympathetic tone activity evaluation to discriminate ketorolac and ketorolac/tramadol analgesia level in swine”, publish by Anesth Analg. 2018 Jun 14. doi: 10.1213/ANE.0000000000003573. [Epub ahead of print] Abstract BACKGROUND: Evaluation of nociceptive–antinociceptive balance during general anesthesia is still challenging and routinely based on clinical criteria. Analgesic drug delivered may be optimized with parasympathetic tone activity (PTA) monitor. This study compares ketorolac and ketorolac/tramadol balance analgesia using a PTA monitor. METHODS: Pain intensity response was assessed using a 0–100 numerical state scale (PTA) after nociceptive stimuli in pigs under stab[...] 02 Jul Researchers of NANBIOSIS Unit 1 and NANBIOSIS Unit 18, led by Prof Antoni Villaverde have published the article “Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin” at SMALL journal. Under the unmet need of efficient tumor‐targeting drugs for oncology, a recombinant version of the plant toxin ricin (the modular protein T22‐mRTA‐H6) is engineered to self‐assemble as protein‐only, CXCR4‐targeted nanoparticles. The soluble version of the construct self‐organizes as regular 11 nm planar entities that are highly cytotoxic in cultured CXCR4+ cancer cells upon short time exposure, with a determined IC50 in the nanomolar order of magnitude. T[...] 01 Jul Laura Lechuga, Scientific Director of NANBIOSIS Unit 4 Biodeposition and Biodetection Unit, at Catalan Institute of Nanoscience and Nanotechnology, has joined the Analyst Editorial Board as an Associate Editor from today. Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions and the applications of those discoveries, unconfined by traditional discipline barriers Laura Lechuga is the CSIC Research Professor at the Catalan Institute of Nanoscience and Nanotechnology, Spain. She is the leader of the CIBER-BBN-ICN2 Nanobiosensors and Bioanalytical Applications Group, which focusses on the technological development of nanophotonic biosensors, their integration into portable lab-on-a-chip platforms and their application in clinical and environmental diagnostics. Professor Lechuga[...] 30 Jun Scientists of NANBIOSIS Units U1. Protein Production Platform (PPP), and U18. Nanotoxicology Unit, have recently published an article titlled “Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs” in the Journal of Controlled Release. Loading capacity and drug leakage from vehicles during circulation in blood is a major concern when developing nanoparticle-based cell-targeted cytotoxics. To circumvent this potential issue it would be convenient the engineering of drugs as self-delivered nanoscale entities, devoid of any heterologous carriers. In this context, we have here engineered potent protein toxins, namely segments of the diphtheria toxin and the Pseudomonas aeruginosa exotoxin as self-assembling, self-delivered therapeutic materials targeted to CXCR4+ cancer stem cells. The systemic administration of both nanostructured drugs in a[...] 29 Jun Eli Prats and Eduard Masvidal researchers of NANBIOSIS Unit 8 Micro and Nanotechnology Unit have shown their last results in ECoG recordings and biosensing using graphene based devices at the 8th edition of Graphene Conference series, the largest European Event in Graphene and 2D Materials, which is taken place in Dresden (Germany) from the 26th until the 29th of June 2018. Eli Prats has spoken on Label-free Direct Detection of Thrombin through graphene SGFET with chemically modified aptamers and Eduard Masvidal has given a talk on Graphene transistors for ultra-slow frequency (< 0.1Hz) in vivo neural recordings showing graphene SGFETs as[...] 28 Jun Sustained release of drug delivery systems (DDS) has the capacity to increase cancer treatment efficiency in terms of drug dosage reduction and subsequent decrease of deleterious side effects. In this regard, many biomaterials are being investigated but none offers morphometric and functional plasticity and versatility comparable to protein-based nanoparticles (pNPs). Researchers of NANBIOSIS units 1 and 18 are co-authors of an article publish by Journal of Controlled Release in which it is described a new DDS by which pNPs are fabricated as bacterial inclusion bodies (IB), that can be easily isolated, subcutaneously injected and used as reservoirs for the sustained release of targeted pNPs. Our approach combines t[...] 27 Jun Scientists of NANBIOSIS Unit 8. Micro – Nano Technology Unit, led by Gemma Gabriel, Scientific Coordinator of the Unit, are the authors of the article “Online oxygen monitoring using integrated inkjetprinted sensors in a liver-on-a-chip system”, published by Lab on a chip. The demand for real-time monitoring of cell functions and cell conditions has dramatically increased with the emergence of organ-on-a-chip (OOC) systems. However, the incorporation of co-cultures and microfluidic channels in OOC systems increases their biological complexity and therefore makes the analysis and monitoring of analytical parameters inside the device more difficult. In this work, theauthors present an approac[...] 26 Jun Scientists of Units 1 and 18 of NANBIOSIS are coathors of the article “Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides” published by Nanomedicine: Nanotechnology, Biology and Medicine Arginine-rich protein motifs have been described as potent cell-penetrating peptides (CPPs) but also as rather specific ligands of the cell surface chemokine receptor CXCR4, involved in the infection by the human immunodeficiency virus (HIV). Polyarginines are commonly used to functionalize nanoscale vehicles for gene therapy and drug delivery, aimed to enhance cell penetrability of the therapeutic cargo. However, under which conditions these peptides do act as either unspecific or specific ligands is unknown. The authors have here explored the cell penetrability[...] 26 Jun Last June 21-22th, took place at the Fira Gran Via in Barcelona, the ONCO Emergence forum, a networking conference focused on setting up transnational collaboration projects in oncology by promoting interaction among research institutes, companies and medical facilities like hospitals. In other to promote alliances and generate collaborative projects from hospitals and academia to other stakeholders, ONCO Emergence Forum Barcelona has created a Tech Transfer Competition that features cherry-picked entrepreneurs, TTO or principal investigators developing new technology ready to be licensed or in development through a spin-off. Selected participants presented their innovative projects in a 6-minute English pitch to an experienced[...] 26 Jun The 3rd VPH Summer School was held in Barcelona, on June 18-22, 2018. The VPH Summer School series is co-organized by the Barcelona MedTEch – Pompeu Fabra University and by the Virtual Physiological Human Institute. The Summer School provides a thorough overview and hands-on experience in state-of-the-art Virtual Physiological Human (VPH) research. The event is dedicated to PhD students and junior postdocs who seeks cross dissemination and a guided experience through the use of computer models and simulations to tackle specific clinical problems, not only engineers but also biomedical scientists and medical doctors with an interest in computer modeling and[...] 25 Jun NANOLIGENT is awarded for the best company in Health Sciences Price given by the law firm RCD. The XXIII Investment Forum of ACCIÓ 2018 was celebrated last June 20th with the aim of connecting with the world of private investment. ACCIÓ, Company Competitiveness Agency, had previously published a catalog of startups with the most potential startups in Catalonia, projects selected from more than 100 candidatures were presented for the 2018 Investment Forum of ACTION. The 50 companies in this catalog stand out due to their differential nature and innovative value, due to their social impact and the involvement of the entrepreneuria[...] 25 Jun Carbon dioxide (CO2) is a known pollutant that affects the performance of humans in workplaces, schools and other indoor areas. Thus, the development of devices for sensing and monitoring CO2 levels is crucial for many fields such as food packaging and for human safety indoors. Researchers of NANBIOSIS U4. Biodeposition and Biodetection Unit, led by Prof. Laura M. Lechuga, are co-authors of the article “A CO2 optical sensor based on self-assembled metal–organic framework nanoparticles published by Journal of Materials Chemistry A., wich shows an optical CO2 sensor fabricated by integration of a metal–organic framework (MOF) onto bimodal optical waveguides. The sensor showed a broad linear[...] 22 Jun Yesterday took place in Barcelona, at Barcelona School of Management, Universitat Pompeu Fabra, a meeting of resarch groups and units of NANBIOSIS and CIBER-BBN and companies in the third B2B Forum organized by NANBIOSIS, in this case together with NANOMED SPAIN. Thirteen companies and twelve groups from CIBER-BBN and CCMIJU (ten of them coordinating NANBIOSIS units) got together to explain, through short presentations of ten minutes, those lines of their work aimed at finding synergies and potential collaborations in the area of Nanomedicine apllications in drug delivery and targeting. There was also a talk by a representative of CDTI (Spanis[...] 21 Jun Ramón Martínez Máñez, Elena Aznar and Ángela Ribes, researchers of Unit 26 of NANBIOSIS, NMR: Biomedical Applications II, in collaboration with researchers from the Universitat Politècnica de València, with the Universitari i Politècnic La Fe Hospital and the Rovira i Virgili University, have developed a new material that allows to detect quickly and with a high sensitivity infections caused by Candida albicans, a type of fungus that can be found in different biological fluids, causing opportunistic infections such as Candidemia or Invasive Candidiasis. According to Javier Pemán, head of section and head of the Mycology Unit of the Microbiology Service of[...] 20 Jun NANBIOSIS’ partners CIBER-BBN and JUMISC, with another 44 European partners, led by Philips Electronics Nederland B.V, will work on the development of next genration catheters. The project, Position-II (Ref. n. 783132), that pretends to diversify the production of smart catheters (overcoming the obsolescence of current ones), improve their performance (facilitating their use to be smaller), reduce current production costs and break existing monopolies, has been submitted to the Call for Electronic Components and Systems for European Leadership (ECSEL)- Horizon 2020, with a duration of three years -starting on 1/6/18- and with a budget of over €41M, (€10.4M-financed by European Union) T[...] 19 Jun Elisabeth Engel, Scientific Director of Unit 5 of NANBIOSIS, U5. Rapid Prototyping Unit, will led the research project, QuirofAM, to produce biodegradable and bioactive scaffolds printed in 3D as osteochondral and maxillofacial substitutes. This is one of the projects to be promoted by LLAVOR 3D Community, an association of Catalan entities, created last month, which includes the IBEC (housing units 5 and 7 of NANBIOSIS). LLAVOR 3D Community aims to accelerate the development and adoption of additive manufacturing and 3D printing technologies by the industry. Within the projects of the LLAVOR 3D Community, new software tools, new materials, more efficient and versatile production[...] 18 Jun Francisco Miguel Sánchez Margallo, Scientific Director of JUMISC, is co-author of the publication “Intestinal histopathological changes in a porcine model of pneumoperitoneum-induced intra-abdominal hypertension” by Surgical Endoscopy. The study was performed with the participation of NANBIOSIS Units: U21-Experimental operating rooms, and U22-Animal housing. and showed that the evolution of intestinal injuries from pneumoperitoneum-induced IAH depends on the degree of IAP, these damages may be associated with decreases in APP and pHi, and increases in Lc For further information: click her[...] 17 Jun Dra. Rosa Villa, Scientific Director of NANBIOSIS U8. Micro – Nano Technology Unit, explained last June, 11 at the Residence of Researchers of Barcelona the great scientific challenges in finding tools that allow a good interaction between the nervous and the artificial system. This talk is part of the series of conferences organized by the CNM with the theme “Why research in micro-electronics?” Dr. Manuel Lozano, Director of the CNM, introduced the talk explaining that with microelectronic technology scientists can capture the signals that occur in the nerves and in the brain and presented Rosa Villa as a doctor with a PhD in[...] 16 Jun Francisco Miguel Sánchez Margallo, Scientific Director of CCMIJU and NANBIOSIS U21. Experimental operating rooms, is co-author of the publication “Interpretation of motion analysis of laparoscopic instruments based on principal component analysis in box trainer settings” published by Surgical Endoscopy The study results show that three new HSMAPs per hand were defined for PG and PC tasks, and two per hand for KS task. PG presented validity for HSMAPs related to insecurity and economy of space. PC showed validity for HSMAPs related to cutting efficacy, peripheral unawareness, and confidence. Finally, KS presented validity for HSMAPs related with economy of space and knotting securitya. Thus,[...] 15 Jun NANBIOSIS U2. Custom Antibody Service (CAbS), is incorporating new equipment as a result of its participation in the project FICTS1420-27, selected by the MINECO for co-financing by the FEDER Program in ICTS 2014-2020. Recently the purchase and installation and set-up of a new nitrogen tank to store cells has taken place. The storage of cell lines of monoclonal antibody-producing hybridomas is a process in which the cells are conserved when they are cooled to temperatures typically at -196 ° C in liquid Nitrogen tanks. With temperatures below -130 ° C the activity Biological ceases and storage at these temperatures is vital to keep the materia[...] 14 Jun The unit 8 of NANBIOSIS U8-Micro, nanotechnology, will offer HIGH-QUALITY GRAPHENE GROWN ON ONE-layer or multi-layer CU SHEETS, as well as graphene transferred to different rigid and flexible parylene substrates while preserving their valuable initial properties This unit has recently upgraded the Aixtron Black Magic Pro 4-inch System for the growth of graphene. It has also been purchased, installed and set-up by the unit parylene deposition device on flexible substrates. With this acquisition the unit will be able to offer high quality graphene grown in monolayer or multilayer CU sheets, as well as graphene transferred to different rigid and flexible parylen[...] 13 Jun NANBIOSIS U4-Biodeposition and biosensing, led by Prof Laura Lechuga, has been recently updated and improved as a result of its participation in the project FICTS-1420-27 , selected by the MINECO for co-financing by the FEDER Program in ICTS 2014-2020. The Biodeposition has been updated with the ozone generation system with a new system (UV / Ozone Cleaner-Procleaner ™), with a lamp with improved power. In the case of the Biodetection unit, the current device has been to updated in order to make it more competitive. Optical components that improve the performance of the instrument in reference to sensitivity have been changed, the fluidic[...] 12 Jun The equipment of NANBIOSIS U6-Processing of biomaterials and nanoestructuring, that at present are in several laboratories of the ICMAB-CSIC, are going to be transferred to their definitive location in the new laboratory of this NANBIOSIS unit. Given the large amount of equipment the process is expected to last two years, and itwill be done sequentially to continue to provide service to laboratory users. In this process, an engineer has been hired to play a key role, since he will not only be in charge of the transfer, but also to ensure the correct installation of equipment after its transfer and[...] 11 Jun NANBIOSIS U20- In Vivo Experimental Platform, led by Dr Simó Schwartz and Dr. Ibane Ibasolo, has recently added new equipment as a result of its participation in the project FICTS1420-20, selected by the MINECO for co-financing by the FEDER Program in ICTS 2014-2020. The new equipment is a Coagulometer (Diagnostica Stago STart® 4 Hemostasis Analyzer) used for measuring the plasma coagulation time upon incubation with different stimulators (PT, APTT, Fibrinogen, D-dimer (quantitative), Thrombin time, Reptilase time etc.) the use o f this equipment will allow the Unit to test the hemocompatibility of novel nanomedicines in development.[...] 10 Jun Francisco Miguel Sánchez Margallo, Assistant Director of NANBIOSIS and Scientific Director of JUMISC, is co-authors of de article “Evaluation of a New Design of Antireflux-biodegradable Ureteral Stent in Animal Model” published by Urology. The research were carried out in the NANBIOSIS units in the JUMISC. The purpose was to determine the effects in urinary tract of a new antireflux-biodegradable ureteral stent. Thirty six ureters belonging to 24 pigs were used. The study began with endoscopic, nephrosonographic, and fluoroscopic assessments. Three study groups of ureters (n = 12) were then specified. In group I, a biodegradable antireflux ureteral stent (BDG-ARS) was inserted in the right ureter[...] 09 Jun Last 7 June 2018 took place in Zaragoza, the Sino-Spain Biomedical and Pharmaceutical Conference, as a result of years of cooperation with Chinese institutions, organizad by Zaragoza University and Aragonese Foundation for Research & Development of Aragon Government (ARAID), to promote initiatives and foster bilateral collaboration in biomedical and pharmaceutical sectors between Spain and China. The themes of the forum were: Molecular engineering for biomedical products Diagnoses &Design for new devices for medical uses Tissue Engineering and regenerative medicine Pharmacology and nanometerials for medical application Advanced therapies for cancer research Researcher of three units of NANBIOSIS partcipated in the Conference: from U13. Tissue &am[...] 08 Jun The biannual Conference on Bioanalytical Sensors will take place in June 24 – 29 in Newport, US, with the theme “State-of-the-Art Bioanalytical Sensing Approaches for Healthcare and Therapeutics, Forensics, and Visualization of Living Systems”. Prof. Laura M. Lechuga, Scientific Director of NANBIOSIS U4. Biodeposition and Biodetection Unit: is giving a Conference on “Photonic label-free biosensors for real-time analysis of untreated clinical and environmental samples” The focus of this meeting is on the development of new bioanalytical tools that provide highly specific and quantitative molecular data of biological systems leading to real applications to the clinic. Specific topics will include micro- and nanofluidics[...] 07 Jun NANBIOSIS researchers have developed a nanomedicine for the treatment of metastases by the selective elimination of tumor stem cells. It is a system based on nanoparticles that transport a chemotherapeutic drug and release it into cancer cells. The research team, led by Esther Vázquez and Antonio Villaverde, Strategy Director of NANBIOSIS U1. Protein Production Platform (PPP), in the IBB-UAB, and Ramon Mangues, Scientific Director of NANBIOSIS U18. Nanotoxicology Unit, in the Sant Pau Hospital, have already created a prototype of the drug and have conducted in vivo trials in animal models of colorectal cancer. They have demonstrated their effectiveness, selectiv[...] 06 Jun Ramon Martínez Mañez, Scientific Director of NANBIOSIS U 26 Biomedical Applications II and Scientific Director of CIBER-BBN, has received the Rey Jaime I Award of New Technologies 2018. Rey Jaime I Awards are granted (in xis cathegories) to people who stand out in their field of work and who have developed most of their professional activity in Spain. Candidates must be nominated by third parties and must prove their qualities. They are recognized as the most prestigious awards for the activity carried out in Spain. It is one of the best paid prizes in the country. Each of them is[...] 06 Jun Elisabeth Engel, Scientific Director of NANBIOSIS U5, Rapid Prototyping Unit, is interviewed in “Deuwatts”, a programe of Btv, devoted to biomedical engineering. Dr. Engel explains how they have designed a dressing with active substances to regenerate skin wounds and talks about bio-printing for therapeutic models. Watch it here. &nbs[...] 05 Jun In the framework of the FEDER Program in ICTS 2014-2020, several projects related to the ICTS NANBIOSIS have been selected by the MINECO for co-financing with FEDER funds of the European Regional Development Funds program. An agreement has been signed between MINECO and CIBER (partner of NANBIOSIS for the co-financing of the Project: “Purchase, installation and set-up of production and characterization equipment to complement the Units: U3-Synthesis of Peptides Unit, U18-Nanotoxicology and U20- In Vivo Experimental Platform”. The total budget of the project amounts to € 307,566.16, with 50% financing with FEDER Funds. Also CSIC (The State Agency Superior Council of[...] 04 Jun Francisco Miguel Sánchez Margallo, Scientific Director of CCMIJU and Javier García Casado, Scientific Director of NANBIOSIS U14, Cell Therapy Unit, are co-authors of the publication “Adipose-Derived Stem Cells Ameliorates Ischemia-Reperfusion Injury in a Rat Skin Free Flap Model” The study was performed with the participation of the following NANBIOSIS Units: U21-Experimental operating rooms, U22-Animal housing, and U14-Cell Therapy Article of reference: DOI: 10.1055/s-0038-1648246 Ballestín A, Casado JG, Abellán E, Vela FJ, Álvarez V, Usón A, Blázquez R, Sánchez-Margallo FM, J Reconstr Microsurg. 2018 May 3. [Epub ahead of print] &nbs[...] 03 Jun On Saturday, June 2, in the auditorium of the Artium museum in Vitoria, a meeting was held for patients with diabetes, organized by the group of European researchers of the DRIVE project with the aim of conecting patiens with researchers. The event was organized by the NanoBioCel research group of the CIBER-BBN and the University of the Basque Country, led by José Luis Pedraz, Scientific Director of NANBIOSIS Unit 10, Drug Formulation, which participates, through the CIBER BBN and the ICTS Nanbiosis, in the Drive Project focused on pancreatic cell transplantation and the development of biomaterials and new surgical devices that improve the transplantation and[...] 01 Jun The results of the research carried out by Scientists of U12. Nanostructured liquid characterization unit, and CIBER-BNN, have been published in an article by ACS Applied Materials & Interfaces: DOI: 10.1021/acsami.7b18648[...] 31 May Javier García Casado, Scientific Director of NANBIOSIS Unit 14: Cell therapy toguether with other Scientists of NANBIOSIS and CCMIJU have issued the first report describing the beneficial effect of human EV-endMSCs on embryo development, which has been recently published by PloS One: “Murine embryos exposed to human endometrial MSCs-derived extracellular vesicles exhibit higher VEGF/PDGF AA release, increased blastomere count and hatching rates“. The results could be relevant for assisted reproduction: “Endometrial Mesenchymal Stromal Cells (endMSCs) are multipotent cells with immunomodulatory and pro-regenerative activity which is mainly mediated by a paracrine effect. The exosomes released by MSCs have become a promising[...] 30 May Prof Laura M. Lechuga, Scientific Director of NANBIOSIS U4 – Biodeposition and Biodetection Unit – is part of the Organising Committee of the 2018 European Conference on Integrated Optics that will celebrate its 20th anniversary in Valencia from the 30th May to the 1st June 2018. In the 2017 edition, which took place in Eindhoven, the conference featured more than two hundred attendees. The conference focuses on leading edge research on integrated optics, optoelectronics and nano-photonics and gathers experts from academia and industry to show their latest technical results, and showcase their products and services. The application scope is broad and it ranges from tele/datacom communications, optical interconnects, and (bio)[...] 29 May The I3A organizes the VII Conference of Young Researchers to be held on June 2, 2018. As in past editions, the Confernce will be addressed to all those who are doing the doctoral thesis whose director or co-director is a member of I3A. Scientists of NANBIOSIS Unit 13 Tissue & Scaffold Characterization Unit will participate with the following poster: Personalized simulation of intraestromal ring insertion surgery (ICRS). Validation with clinical data. Julio Flecha, Miguel Ángel Ariza-Gracia, Jesús Zurita, Begoña Calvo Simulation of cell populations in Organ-On-Chip devices: of the models classics to data driven simulations. Jacobo Ayensa-Jiménez, Marina Pérez Aliacar, Teodora Randelovic, Sara Oliván, Iñaki Ochoa,[...] 28
Innovative Copper-Based Nanoparticles Open New Frontiers in Glioblastoma Treatment
Ibima: At the Forefront of Research with a Unique New Infrastructure in Andalusia
Leadership changes and their new contribution to cutting-edge MRI research
New Database Provides Valuable Insights into Predicting Sudden Cardiac Death and Atrial Fibrillation
NANBIOSIS enables new breakthrough study on Carotid Plaque vulnerability
NANBIOSIS Unit invited to PEGS, the Protein & Antibody Engineering Summit
Ready your proposals: Our Open Call starts on january 2025
New Solutions to Old challenges: Key Symposium on Nanomedicine Against Cancer
Jesús Santamaría awarded with the ‘Aragón Investiga’ for his Research Excellence
NANBIOSIS in the CIBER Conference in Valencia
The Protein Production Platform (PPP) at the UAB Innovation Fair
European Partnership Opens a New Era in Rare Disease Research
The Soft Lab held a new edition of the course on characterization and preparation of particulate materials
A project on pediatric respiratory infections, led by NANBIOSIS, wins the CIBER Young Researcher Call
Prof. Ramón Martínez, Director of NANBIOSIS, has been awarded the Spanish National Research Prize
Knowdlege growth: A chart-guide for cloning, production, purification, and characterization of recombinant proteins from prokaryotic systems
Nanotechnology to slow down the growth of glioblastomas
Harnessing Nanotechnology in protein research: Insights from Dr. Neus Ferrer on new ways of fighting antimicrobial resistance
Latest breakthroughs in pulmonary drug delivery and cancer research at NANBIOSIS
Gene Therapy for Cystic Fibrosis: new inspiring scientific collaboration
New gene therapy for Cystic Fibrosis: an interview with Lucía Enríquez
Prof. Jose Luis Pedraz, new “Académico de Número” of the Spanish Royal National Academy of Pharmacy
Prof. Pilar Marco takes helm of CIBER-BBN: Leading the future of Bioengineering, Biomaterials, and Nanomedicine
Cardiovascular disease and Computation: an innovative lecture by Prof. Shirley Jansen
Temperature-sensitive hydrogels: A pioneering therapeutic approach for ovarian cancer
2nd Open call 2024 for preferential access to the ICTS NANBIOSIS
Last seat: Our Training in Spectroscopy and MRI for animal testing applications is still open.
New cathalitic therapy for destroying key molecules within tumor cells
Protein-only Materials offer a new hope in colorectal cancer treatment
NANBIOSIS research infrastructure improved with the acquisition of new cutting-edge equipment
Workshop of the Health Innovation Group of MATERPLAT
The revolutionary path of research in NANBIOSIS and advice on Woman’s Day 2024
Resolution of the 1st competitive call of 2024 for access to NANBIOSIS
New immunization research for SARS-CoV-2 with the collaboration of NANBIOSIS
Women in NANBIOSIS part 6: A conversation with Ana Mincholé on unlocking the heart’s secrets
Women in NANBIOSIS part 5: Susana Vílchez and her insights on water-in-water emulsions and gender equality in Science
Reaching for the unreachable: New efforts to treat Lysosomal Storage Diseases
The new official webpage of RED-DM is coordinating research efforts in Myotonic Dystrophy
The fight against rare respiratory diseases: New hope in detection and treatment
New upcoming events: The active role of NANBIOSIS in awareness of rare diseases
Women in NANBIOSIS part 4: María Sancho’s journey from nanomaterials to cancer therapy
Women in NANBIOSIS part 3: Professor Fany Peña, her insights in research, parenthood, and persistence
The NABIHEAL Project Pioneers Wound Healing with New Biomimetic Matrices
Women in NANBIOSIS part 2: Ana Martín, and her Multi-degree Journey
Women in NANBIOSIS part 1: Anna Aviñó, from Curiosity to Innovation
Polymeric Micelles Delivering Hope: A Revolutionary Strategy to Fight Cancer
Women in NANBIOSIS: Our New Interview Series
Bringing Hope to Cancer Treatment: New Pioneering Advances in Nanotechnology
‘Magic Bullets’ Against Cancer: Unveiling the Potential of DNA Nanoparticles
1st Open call 2024 for preferential access to the ICTS NANBIOSIS
NANBIOSIS U1_Protein Production Platform expands its facilities at the Autonomous University of Barcelona, strengthening its capabilities.
Good News! Protein Nanoparticles with a New Ligand Select and Destroy Tumor-associated Fibroblasts”
NANBIOSIS U1 PPP invited to PEGS, the Protein & Antibody Engineering Summit
From the molecule to the bioassay by Custom antibody service (CAbS)-NANBIOSIS U2 as a PTI+Global Health Infraestructure
The door is now open to a new nanoparticle-based treatment for chronic liver disease
Rosa Hernández of the NanoBioCel group-NANBIOSIS U10 has received the Female Talent Award 2023 Women and Science
Impactful research with NANBIOSIS participation in the Poster Tour of CIBER-BBN & CIBEREHD Annual Conference.
NANBIOSIS sesion in the CIBER-BBN and CIBEREHD annual meeting. SAFE-N-MEDTECH Project: Outcomes and Future Prospects.
Open Position: Science Communicator for NANBIOSIS ICTS in Valencia
Technical seminar on materials characterisation equipment
NANBIOSIS U1 at UAB Innovation Fair
The importance of bacterial Quorum Sensing (QS) research recognised in the Princesa of Asturias Awards
Developing Support Technologies for adressing traslational gaps in regenerative medicine.
3D Printing and Bioprinting for Pharmaceutical and Medical Applications
Carlos Rodriguez-Abreu (NANBIOSIS U12) keynote speaker at the European Colloid and Interface Society ECIS 2023
2023 Annual Conference of CIBER-BBN and NANBIOSIS with CIBEREHD
ICTS participation in the First guide to facilitate the sustainable design of printed electronic devices
NANBIOSIS receives the support of the Spanish Research Agency (Ministry of Science and Innovation) financing the NANBIO-ACCESS project, in the 2022 call for Excellence Research Networks.
Resolution of the 2nd competitive call of 2023 for access to NANBIOSIS
Jesús Santamaría, Scientific Director of NANBIOSIS Unit 9, elected foreign member of the Istituto Lombardo Accademia di Science et Lettere
New equipment adquired to improve NANBIOSIS U20
The role of microfluidics and 3D-bioprinting in the future of exosome therapy. A high impact review
Symposium Tribute to Prof. Pepe Becerra “40 years of the Bioengineering and Tissue Regeneration Laboratory (LABRET)”
2023 Annual Conference of CIBER-BBN and NANBIOSIS
Representatives of the Ministry of Science and Innovation visited unit 16 of NANBIOSIS
2nd Open call 2023 for preferential access to the NANBIOSIS ICTS
Workshop on Hyperthermic Oncology
New look of Nb4D – CAbS (NANBIOSIS U2) “Revolutionising Diagnosis”
NABIHEAL project launches website
Safe-n-MedTech celebrates its 48th Month Management Committee Meeting
NANBIOSIS U16 enlarges its capacities with a new FlexPS-ARPES-E kit
A discovery in one of the most aggressive cancers will allow more efficient diagnosis
Nanoparticles to modulate topography and ligand distribution at the nanoscale: impact on cell behavior
Resolution of the 1st competitive call of 2023 for access to NANBIOSIS
Rare diseases international day 2023: some NANBIOSIS contributions
New method for the detection of RNA viruses such as SARS-CoV-2
“CIBER is collaboration”
Advancing a novel nano-pharmaceutical towards clinical translation
Scientific presentation and use of the piezoelectric micromanipulator and the time-lapse incubator within the framework of the Genera Project
1st Open call 2023 for preferential access to the ICTS NANBIOSIS
New nanoarchitectonics of RGD peptide developed using quatsomes as robust tool in tissue engineering.
New Time-Lapse Incubator for assisted reproduction research
New European Project NABIHEAL in biomaterials for complex wound healing
“Preparation and characterization of SOFT Materials” Technical Seminar
Three articles acknoledging NANBIOSIS contribution awarded at the Bioaraba Research and Innovation Conference
Happy Day of Chemistry! The role of Chemistry in a sustainable research in health
MATERPLAT 2022 General Assembly and Puzzle X
Researchers of two NANBIOSIS units success in the Third Millennium Awards
Applications of data-driven dynamics to oncology and neuromodulation
A fantastic reunion of the CIBER-BBN and the NANBIOSIS research community.
II Scientific Communication course
Ramón Martínez Máñez, Scientific Director of NANBIOSIS U26 obtains an ERC Advanced Grant
NANBIOSIS U7 at the 15th IBEC Symposium October 2022
Microchannel capillarity pumping design by Prof. Guillermo Artana
New edition of the course on characterization and preparation of particulate materials.
The first TECNIO Conference and NANBIOSIS’ researchers participation
The sprint of the European Project Moore4medical
Biomedicine Project Manager job vacancy
Nanoligent raised €2.8 M and completed Seed round financing with support of i&i Biotech Fund
NANBIOSIS in the NEW BOOK of the Unique Science and Technology Infrastructures (ICTS)
7th Annual Meeting of the Unique Science and Technology Infrastructures in Spain
Philipps-Universität Marburg (Germany) -NANBIOSIS U25 collaboration on the study of tumour microenvironment (TME) changes in Glioblastoma
The University of Valencia among the 300 best universities in the world, hosting NANBIOSIS U26 of CIBER-BBN on RNM for Biomedical Applications
Two NANBIOSIS Units of CIBER-BBN at UAB, one of the 300 best universities in the world, according the Shanghai Ranking
1st Nanomedicine Forum of CIBER-BBN/NANBIOSIS and CSIC Nanomed Conection
Metal-free contrast agents: novel approaches
How engineered protein helps Nanomedicine againts Cancer
1st Forum of CIBER-BBN/NANBIOSIS and CSIC Nanomed Conection researchers
NANBIOSIS in the new poster of ICTS map published by Spanish Goverment.
How to accomplish researchers’ goals with Confocal Microscopy: the tools, the know-how and the expertise you need
“The almighty graphene”, a podcast by Elisabet Prats
Nora Ventosa appointed Research Professor under the Materials Science
Improving quality of MR spectra from mouse brain. MRSI-detected pattern in glioblastoma patients
Induced pluripotent stem cells in disease modelling and experimental therapies: cardiovascular perspective
OPEN SUBMISSION FOR JOURNAL SPECIAL ISSUE ON OLIGONUCLEOTIDE BASED THERAPIES
Wide representation of NANBIOSIS research in NALS 2022 and best Oral Presentation to Eloi Parladé
CRISPR technologies for Cystic Fibrosis treatment
New Summer School “The medicine of the future: Nanomedicine”
OPEN SUBMISSION FOR FRONTIERS IN CHEMISTRY SPECIAL ISSUE ON NUCLEIC ACID-BASED APTAMERS IN THERAPEUTICS AND DIAGNOSTICS
NANBIOSIS renews its accreditation as Singular Scientific and Technical Infrastructure (ICTS)
The coming revolution: synthetic DNA and RNA for therapeutic and diagnostic applications
Experimental & molecular medicine: a new article with NANBIOSIS U17
ISO 9001:2015 Quality Certification for the Soft Scientific and Technical Service at ICMAB and Unit
Researchers of NANBIOSIS U8 highlighted in the World Health Day
Targeting of the breast cancer stem cells to improve the treatment of triple negative breast cancer
1st Meeting with Cystic Fibrosis Patiens (NanoBioCel -ARNASA)
Is it possible to communicate microorganisms from different kingdoms? Yes, it is, using “Nanotranslators”
New equipment installed in NANBIOSIS U20
The results of POSITION II highlighted by CORDIS: A pan-European alliance for the next generation of smart catheters
The efficacy of nanoparticles combined with chemotherapy against pancreatic cancer
Gold Nanoparticles Synthesized by NANBIOSIS U9 will destroy tumor cells without drugs
Open Call Focus on Innovative MedTech using Nanotechnology
Conversations with women scientists: Cardiology
Fabry Desease in the Rare Disease Day: A New Hope
SAFE-NMT Open Call for development and market of innovative MedTech solutions based on nanotechnology
The integrin beta1 modulator Tirofiban prevents adipogenesis and obesity by the overexpression of integrin-linked kinase: a pre-clinical approach in vitro and in vivo
AWARDS of the Academy of Pharmacy of Castilla y León 2021 to researchers from NANBIOSIS U10
Women in the fight against breast cancer: Ibane Ibasolo
Women in Signal Processing: Raquel Bailón
Women Scientists in your neighborhood: Estefanía Peña
Stable nanovesicles for the delivery of microRNA in cancer treatment
Nanoligent, whoes founders are leaders of NANBIOSIS units, raises €1M in Series Seed financing
Multivalent self-assembled platforms for the delivery of chemotherapeutic drugs
Submissions open for Special Issue of MDPI on Fluorescent Organic Nanoparticles for Bioimaging and Theragnostics
Best Emergeging Researcher Award in the Biomedical Area to Edorta Santos
New fluorescent nanovesicles for intracellular biomarker detection
The activity of Peptide T22 as antimicrobial drug opens new possibilities for the local control of bacterial infections related to tumors
New graphene-based neural probes improve detection of epileptic brain signals
Nora Ventosa, president of the TECNIO Association.
New results evidence new biomarkers for early diagnosis of P. aeruginosa infections
Two great scientists and excellent people pioneers on Nucleic Acids Chemistry
The suitability of flexible graphene depth neuralprobes for in vivo electrophysiology research
1,800,000 euro for the improvement of NANBIOSIS laboratories
The Medicine of the Future needs the Nanomedicine Revolution. This is why
‘SAFE-N-MEDTECH’ and ‘PHOEHIX’ OITBs in CIBER-BBN and NANBIOSIS annual Conference.
Nanomedicine in the Medicine of the Future
New therapeutic strategies for the treatment of advanced breast and colon cancer
Extracellular vesicles secreted by cancer stem cells promote angiogenesis and disease progression
New Equipment available for the Regenerative Medicine Research Line of the U10 of NANBIOSIS
‘Point-of-care or PoC’ devices are able to directly detect the genetic material of the virus in just 30 minutes
Vaccines against Covid, biomedical signal processing for sleep disorders and regenerative medicine, at the XV CIBER-BBN Annual Conference
Colloidal nanocrystals for energy applications
Nanobodies for biosening at the European Biosensor Symposium digital seminars
Dr Ramón Mangues, new member of the Royal Academy of Pharmacy of Catalonia
NANBIOSIS U6 opens its doors to students of Nanoscience and Nanotechnology Degree at UAB
CIBER renews its ISO 9001: 2015 Quality Certificate for its Management System
ISO 9001-2015 Quallity Management Certification for NANBIOSIS U12
Pablo Laguna talking about Physiologically driven biomedical signal processing at the Autonomous University of San Luis Potosí
Results of the POSITION-II Project “A pilot line for the next generation of smart catheters and implants”
“Ring Around the Rosy”
Piezoelectric-assisted micromanipulator for assisted reproduction research
Intracoronary Delivery of Porcine Cardiac Progenitor Cells Overexpressing IGF-1 and HGF in a Pig Model of Sub-Acute Myocardial Infarction
Scientific Communication course
The hepl for researchers to commercialise their life science research tools.
Cristina Pérez, Young Investigator Award at the STAFF congress
Diego García, finalist in the Young Researcher Award at the CinC
High quality antibodies for very challenging projects
The European Researcher’s Night with NANBIOSIS’ scientists.
European Biosensor Symposium digital seminars, co-organized by Pilar Marco
Filtered Air Shower for Animal Housing
New leaflets available of new equipment at NANBIOSIS Unit 16
New strategies with nanoparticles to fight the most aggressive breast cancer
Annual CIBER-BBN and NANBIOSIS Conference 2021 – SAVE THE DATE
Characterization of encapsulated porcine cardiosphere-derived cells for cardiac regeneration.
Inkjet printing technology is driving innovation of sensors for point-of-care devices
Radical Dendrimers as Contrast Agents for Magnetic Resonance Imaging
Study of new liposomes for the delivery of enzymes through biological membranes
New NANBIOSIS’ focus on Cutting-Edge Biomedical Solutions
Jaume Veciana awarded by the Catalan Society of Chemistry with the Prize to the Scientific Excellence
Online Course in Basic Procedures and Introduction to Mesenchymal Stem Cell Culture
New project ExofluidTT for the production of nanovesicles using microfluidics applicable on Biomedicine
Ibane Abasolo new Scientific Director of unit 20 of NANBIOSIS
New Nanomedicines for the topical treatment of complex wounds
Purchase, installation and implementation of a treatment, distribution and management system for the environmental control and registration of animal housing rooms
Awarded works for improvement and adaptation of the spaces for the maintenance of the experimental models in the CCMIJU’s Animal Housing
A project by NANBIOSIS researchers, focused on COVID-19 detection and therapy, selected in ‘La Marató’ research program
New drug delivery system for prolonged pain relief
Novel nano-encapsulation approach for efficient dopamine delivery in Parkinson’s treatment
New call for ICTS for the construction, development, instrumentation, equiment and improvement of ICTS capabilities
New device for more efficient gluten detection
A new biosensor will help for the early diagnosis of breast cancer
A potential solution to decrease toxicity in colorectal cancer treatment
The importance of Nanomedicine and Bioengineering to address health challenges
NANBIOSIS participates in a transversal action of CIBER incorporated into the Biobanks and Biomodels Platform of the Carlos III Health Institute
Collaboration in the CSIC White Paper “New Challenges in Biomedicine and Health”
Practical Sessions in the Master of Cosmetic and Dermopharmacy by NANBIOSIS U12
Collaboration in the CSIC White Paper “New Challenges in Biomedicine and Health”
Five experts explain the results of the CSIC Global Health Platform after a year of research on the SARS-CoV-2 coronavirus
Course on Introduction to Research and Laboratory Techniques in Biosciences
First Dresselhaus Prize of the SCN2 to María Jesús Ortiz
Supply, installation and implementation of a document control system, LIMS management and equipment, to enhance the capacities of the distributed ICTS Units (NANBIOSIS -AILIMS).
Uraemic toxins impair skeletal muscle regeneration by inhibiting myoblast proliferation, reducing myogenic differentiation, and promoting muscular fibrosis
Elena Aznar Gimeno (NANBIOSIS U26) leads a CIBER-BBN transfer project.
Collaboration of two NANBIOSIS units in the Valorisation Project “ADVERT”
Participation of NANBIOSIS U25 in the Valorisation Project MR-INITIATE
Launching the Preliminary Market Consultation Webinar of the TREMIRS Project: Minimally Invasive Robotic Surgical Systems
New organ-on-chip models provide new information for targeted treatments in personalised medicine
Toxicity evaluation on non-target organisms with the collaboration of NANBIOSIS U17 Confocal microscopy
A GLOBAL VISION OF THE COVID-19 PANDEMIC by CSIC
A new european infrastructure will facilitate the transfer of nano-pharmaceuticals from the lab to the clinic
In search of antimicrobials from natural bee products to coat implantable biomaterials, avoiding resistance.
Extracellular vesicles as vehicles for therapeutic enzymes in lysosomal deposition diseases
The relevance of biomedical signal processing in the understanding of biological systems
Development of a protein-only drug delivery system for sustained release
A new generation of devices for the rapid, cheap and easy diagnosis of candidemia.
CAMPUS JUMISC online training
Modulation of intercolumnar synchronization by endogenous electric fields in cerebral cortex with neuroprobes by NANBIOSIS unit 8
Simo Schwartz: new General Director of the Bank of Blood and Tissues of Catalonia.
Reversing pulmonary fibrosis has been achieved in murine models with peptide-loaded nanoparticles
Graphene sensors read low-frequency neural waves associated with distinct brain states
CCMIJU leads an European Project based on mixed reality and 3D printing applied to medical education
A more effective nanomedicine has been developed for the treatment of Fabry rare disease.
An Auristatin-based nanoconjugate reduces leukemia burden in a disseminated AML model
New COVID-19 Diagnostic System Ready for Trials in Clinical Samples
A nanotoxin targeting the receptor CXCR4 blocks lymphoma dissemination
Gels formed from the interaction of lipid vesicles: Influence of charge in their structural and rheological properties
Agreement signed with Spanish Government for the allocation of FEDER funds for NANBIOSIS ICTS units at JUMISC
Identification of a novel nanotherapy active in cancer cells resistant to chemotherapy
NANBIOSIS Scientific Women in the International Day of Women and Girls in Science
Agreement signed with Spanish Government for the allocation of FEDER funds for Nanbiosis ICTS
Nanoparticles to eradicate Cancer Stem Cells
Design and engineering of tumor-targeted, dual-acting cytotoxic nanoparticles
12th Workshop on Magnetic Resonance Spectroscopy and Imaging (MRI/MRS) Applied to Laboratory Animals
New spin off of VHIR “BSURE Medical” led by Simó Schwartz (NANBIOSIS U20)
Encapsulation of BSA/alginate water–in–water emulsions by polyelectrolyte complexation
Smart-4-Fabry final workshop
New Center for Research in Advanced Pharmaceutical Development
Electrocardiogram-Derived Tidal Volume During Treadmill Stress Test
Hybridization of men and machines, with Rosa Villa
Nucleic Acids Chemistry, new book release by Ramon Eritja
New patented peptide to allows the faster internalization of drugs within cells and the design of more effective therapeutic nanoconjugates
Graphene active sensor arrays for long-term and wireless mapping of wide frequency band epicortical brain activity
A rare genetic bone pathology is identified from massive sequencing methods
Inkjet Priting Technology, Manufacture and validation of electrochemical sensors in medical applications
Outstanding Young Researcher Award at ICESS 2021 to Konstantinos Mountris (NANBIOSIS U27).
New Scanning Electron Microscope and on line Seminar to explain it for internal and external accesses on NANBIOSIS U12
NANBIOSIS Unit 2 obtains the Biosafety Level 2 Accreditation
Chemical composition of explanted deteriorated nephrostomy polyurethane-catheters through X-ray photoelectron spectroscopy
Non-viral mediated gene therapy in human cystic fibrosis airway epithelial cells recovers chloride channel functionality
New equipment for calorimetry and surface characterization for NANBIOSIS U16
Video-summary of the CIBER-BBN and NANBIOSIS 2020 Annual Conference
Printed sensors, a low cost alternative for clinical detection
Three Nanbiosis units work in the development of new sensors for the better detection of the fungus P. jirovecii, responsible for Pneumocystis pneumonia
Funded beamtime for SMEs in Sincrotron Alba ICTS thanks to EU CALIPSOplus projec. – Dec. 17 explanatory Webinar Calipsoplus-TamaTA for SMEs
Ignacio García and Javier Bonet present their work on the CADENCE project in a one-minute video
Mimicking lymph-nodes to proliferate T cells by Judith Guasch in Onda Cero Radio.
Highly sensitive monoclonal antibodies for a new biosensor for hormones detection in fertility treatments
Looking for volunteers to validate an online learning of minimally invasive surgery (MIS) platform in the framework of EASIER project
NANBIOSIS at the I3A I Conference – IX Conference of Young Researchers
NANBIOSIS participation in the Technology and business Forum “Technological challenges derived from COVID-19”
2020 Rei Jaume I Awards ceremony – Laura Lechuga NANBIOSIS U4-
Nb4D group- NANBIOSIS U2 receives the acreditation TECNICO, in the on line event organizes by ACCIO
Two new equipment items at the U6 of Nanbiosis with cofinancing from FEDER funds
The Nanomedicine Revolution
NANBIOSIS U12 expands its capabilities with a new SEM for morphological and dimensional characterization of solid samples
NANBIOSIS-ICTS AT CASEIB 2020
Closer to understand the regulation of SMARCA4 expression
Moore4Medical a project to accelerate innovation in electronic medical devices
Understanding human heart behaviour with mathematics and engineering.
Ainhoa González Pujana, NANBIOSIS U10, 2019 best doctoral thesis award by the Bioaraba Research Health Institute
New Webinar: Introduction to regulatory aspects of in vitro diagnostic (IVD) medical devices
Update on biomaterials, bioengineering and nanomedicine, with a focus on COVID-19, at the annual CIBER-BBN conferences
Laura Lechuga: awarded the most important recognition in Spain in the field of scientific research
How to delay vision loss in hereditary retinal dystrophies? Looking for the most effective and economical pharmacological nanotherapy
Nb4D group – NANBIOSIS Unit 2 CAbS – accredited with the TECNIO seal
NANBIOSIS in the new poster of ICTS map published by Spanish Goverment.
Third edition of the course on “Characterization techniques for Particulate Materials” with Amable Bernabé
Laura Saenz del Burgo, NANBIOSIS U10, award for the best emerging researcher at the XXI Bioaraba Research and Innovation Conference
Regenerating ankle joints with collagen- and gelatine-based implants
CIBER-BBN and NANBIOSIS at CIBEREDH Scientific Annual Meeting
III Course on Introduction to research and laboratory techniques in Biosciences
Jesús Santamaría, Scientific Director of NANBIOSIS Unit 9, candidate to the Rectorate of the University of Zaragoza
How to take advantage of the body’s natural processes to create innovative therapies?
CIBER-BBN´s XIV Annual Conference
Prof. Pilar Marco, in the program “Meridiano Turing” of RTVE explains the COVID-19 tests.
CLINAM 2020: Clinical Nanomedicine and the Impact of Digitalization and Artificial Intelligence for Precision Medicine
Researchers of NANBIOSIS U3 working in a project to develop molecules with neutralizing properties of SARS-CoV-2
Electrochemical sensors for cortisol detections: Almost there
Laura Lechuga awarded the 2020 Rei Jaume I Prize in New Technologies
Novel Quatsome nanovesicles, prepared using compressed CO2, for the development of advanced nanomedicines
Women Technologist Ada Byron Award to Laura Lechuga, Scientific Director of NANBIOSIS U4.
Job offer: FULLY-FUNDED PhD FELLOWSHIP at the University of Zaragoza
#QueSigaLaCiencia #ScienceMustGoOn!
Workshop “Translational issues in nanomedicine” with NANBIOSIS U6 researchers at ETPN2020
New test trials to diagnose Covid 19: Ramon Martinez, Scientific Director of CIBER-BBN is interviewed by Spanish Television
Impact of Extracellular Vesicle Isolation Methods on Downstream miRNA Analysis in Semen
Nanoprobes for the next generation of Optical Imaging
New updated version of the CSIC report on COVID-19
XIV COURSE OF LAPAROSCOPIC SURGERY OF COLON
NANBIOSIS U12 researchers modify contact lenses to reduce the risk of bacterial infection
COVID-19 detection system: a fast, cheap and easy to use alternative to PCR.
Combination of stem cell therapy and laparoscopy for the treatment of congenital hernia
How Nanophotonic Label-Free Biosensors Can Contribute to Rapid and Massive Diagnostics of Respiratory Virus Infections: COVID-19 Case
II Conference on Nanotoxicity. “Dosis sola facit venenum”
NANBIOSIS Expertise in the IQAC-CSIC Symposium dedicated to the fight against Covid-19 Pandemic
Scientists of Bionand, University of Malaga and CIBER identify a new drug that could mitigate the consequences of COVID infection.
New project to alleviate the effects of Covid will be developed by JUMISC, partner of NANBIOSIS
Maastricht Simulation Award to Konstantinos Mountris and Esther Pueyo
OITBs OPEN CALL TO FIGHT COVID19 – SafeNMT OITB project
Robust Conditional Independence maps of single-voxel Magnetic Resonance Spectra to elucidate associations between brain tumours and metabolites
CSIC publishes a report that summarizes the scientific knowledge on Covid-19 and the research projects
NANBIOSIS U4 expands its capabilities with a upgrades
The ATTRACT Online Conference open for registration
The University of Zaragoza, in the elite of the 500 best universities in the world
The Autonomous University of Barcelona, in the elite of the 300 best universities in the world
NANBIOSIS U2 expands its capabilities with a two new equpipments
The Immunomodulatory Signature of Extracellular Vesicles From Cardiosphere-Derived Cells: A Proteomic and miRNA Profiling
A Study of Fluid Dynamics and Chemical Parameters
Innovation Radar “Great EU-funded Innovations”
II Conference on Nanotoxicity, organised by Nanomed Spain, NANBIOSIS and Materplat, Sept. 22
Workshops on Robotic Surgery with experimental models at CCMIJU
The Scientific Director of NANBIOSIS Unit 7, awarded with the Narcís Monturiol medal for his contribution to science and technology
Unlocking the brain with novel graphene technology
Biocidal releasing dressings of natural origin to treat topical wounds and avoid antibiotic resistance
Cardiac hypertrophy research with NANBIOSIS unit 17 Confocal Microscopy Service participation
A new nanoconjugate blocks acute myeloid leukemia tumor cells without harming healthy ones
From natural by-products to cell delivery systems for regenerative medicine
II Course on introcuction to research and laboratory techniques in biomedicine
Manuel Doblaré, researcher of NANBIOSIS U13, new Chairman of IMDEA Materials Foundation
NANBIOSIS scientists in Aragón, explain on TV their research againts coronavirus
Optimization of Recycled-Membrane Biofilm Reactor as a sustainable biological treatment for microcystins removal with nanbiosis expertise.
The European Commission releases a video showing the European project against coronavirus led by prof Laura Lechuga
Hydrogels structured with dual stimuli responsive for biomedical applications
Seminar on Molecular probes and gated materials in biomedical applications by Ramón Martínez, now in youtube
NANBIOSIS researchers featured in the 15th Edition of Spanish Researchers Ranking
Open call for contribution to the Special Issue by MDPI in IJMS about “In Vivo Biomarkers for Immunotherapy Efficacy in Brain Tumours”
Expoquimia hosts the INDUSTRIAL DIALOGUES Webinars with Nora Ventosa
Automatic Detection of Slow Conducting Channels during Substrate Ablation of Scar-Related Ventricular Arrhythmias
New methods to detect Coronavirus: interactive webinar on the diagnosis of COVID-19
New fluorescent organic nanoparticles to see the invisible
Peptide‐Capped Mesoporous Nanoparticles: Toward a more Efficient Internalization of Alendronate.
A recombinant SARS-CoV-2 vaccine
A project to develop rapid and early diagnostic tests of Covid-19 to reduce false negatives
“We need a drastic change in the organization and management of science”
New therapy for triple negative breast cancer is successfully tested in preclinical animals
Scientific trends with the participation of NANBIOSIS expertise
NAV-GAL, a new senolytic drug against cancer, on spanish TV
“Molecular probes and gated materials in biomedical applications and communication between nanoparticles” by Ramón Martínez
CoNVaT, the ‘Nanotrap’ for the coronavirus – highlighted by BBVA Fundation
NANBIOSIS Scientists discover a promising effective alternative to reduse relapse rates in Diffuse Large B-cell Lymphoma Cells
Neurocardiac Oscillation in Repolarization and Cardiac Arrhythmias
Prof. Laura Lechuga is part of the experts advising the government on the COVID-19 crisis
JUMISC will carry out PCR test for COVID-19 infections
A new compound removes senescent cells and reduces toxicity in cancer treatment
Pilar Marco explains on TV her group’s research against Covid-19 pandemic
Scientists from NANBIOSIS selected by Barcelona Activa “Preacceleration” Program
Microencapsulated Insulin-Like Growth Factor-1 therapy improves cardiac function and reduces fibrosis in a porcine acute myocardial infarction model
A Concise Review on Nano-emulsion Formation by the Phase Inversion Composition (PIC) Method
NANBIOSIS U27 researchers working in an App for the early diagnosis of covid-19 through mobile phones
Wearable Armband Device for Daily Life Electrocardiogram Monitoring
Biosensors for Pandemics
JUMISC will invest 7.3 million in the development of new surgical robots
Infrared sensitive hydrogels to control the regeneration of bone tissue.
A new strategy to synthesize Chol-PEG “on demand”
Nanbiosis among the European Research Infrastructures working for COVID-19 Pandemics
Rosa Villa, Scientific Director of NANBIOSIS U8, New CIBER-BBN group leader
COVIDー 19: diagnosis advantages and limitations of different techniques
NANBIOSIS U2, U3 & U29 participate in the POC4CoV project to develop diagnostic technologies for SARS-COV-2
Stem cells and COVID-19 research.
COVID-19 research: preferent access to NANBIOSIS
Laser-driven direct synthesis of carbon nanodots and application as sensitizers for visible-light photocatalysis
“Have we lernt the lesson?”
NANBIOSIS keeps working in SAFE-N-MEDTECH!
Peptide functionalized nanoliposomes for biomolecule intracellular delivery, prepared using compressed CO2
CALL FOR EXPRESSIONS OF INTEREST FOR FINANCING OF RESEARCH PROJECTS ON COVID-19
Covid-19 vaccine resear will be founded with 30 million € by the Spanish goverment
Laura Lechuga talks about CONVAT, the project for a faster and cheaper diagnose of COVID-19
COVID-19 diagnose, faster and cheaper.
New COVER in Chemistry. A European Journal: an active organic radical stable agains racemization!
Rare diseases Day February 29: combating Fabry Disease
Course on Coloretal Endoscopy for Surgeons
#RareDiseaseDay: Fabry lysosomal disease
Preliminary Market Consultation (CPM): technology development in the field of organ preservation.
Organ-on-chip monitoring. Breakthrough technological approximations
Challenges in precision medicine
Mechanism and Consequences of the Impaired Hif-1α Response to Hypoxia in Human Proximal Tubular HK-2 Cells Exposed to High Glucose
VII Course of Microscopic and Piezoelectric Techniques in Dentistry: Endodontics, Implantology and Prosthetics
NANBIOSIS #WOMEN IN SCIENCE
A new smart drug that finds and kills metastasis cells could be applied in 23 types of cancer
Ethylcellulose nanoparticles as new “in vitro” tool for cell transfection
NANBIOSIS research to fight cancer
EUROAGE: to improve people’s quality of life and increase healthy life expectancy
New book by NANBIOSIS U14: Basic research procedures in the cell therapy laboratory
POSITION II WORKSHOP #5 IN LEUVEN, BELGIUM
Researchers from NANBIOSIS Unit 8 opt for the Cutting-Edge Science Award: How to measure brain’s hidden activity.
Support for companies: Nanotechnological Bonds
PICCOLO Project 7th Face-to-Face Meeting at JUMISC (NANBIOSIS)
II COURSE FOR THE PERFORMANCE OF FUNCTIONS A, B AND C IN RODENTS, LAGOMORPHES, CARNIVORES, PIGS AND SMALL RUMIANTS
A new fluorescent probe for NO
Tumor Immunology and Cancer Immunotherapy Course
New nanocarrier for bio-imaging and drug-delivery applications
BASIC COURSE FOR UROLOGIS: INTRACORPOREAL SUTURING
A step forward in the field of organic free radicals acting as chiral emitters
A step forward for the design of multifunctional protein nanomaterials for cancer therapies
Pilar Marco honored by the Spanish National Research Council (CSIC)
Why the poor biodistribution so far reached by tumor-targeted medicines?
Artificial inclusion bodies for controlled drug release
A new method simple and efficient for the preparation of Oligonucleotide-protein conjugates
A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models
Inkjet printing and paper sensors to control different analytes with low cost technologies
NANBIOSIS Unit 18 expands its equipments and capabilities
“Tips and tricks to achieve good results at the bench”
Carlos Rodriguez-Abreu (NANBIOSIS U12) keynote speaker in OKINAWA COLLOIDS 2019
NANBIOSIS internal dissemination day
NANBIOSIS in the NEW BOOK of the UNIQUE SCIENTIFIC AND TECHNICAL INFRASTRUCTURES (ICTS)
Agreement signed with MINECO for the allocation of FEDER funds for NANBIOSIS ICTS
I ONLINE Course on Introduction to Quality Management in Laboratories in the Biosanitary Field
Understanding between doctors and engineers: essential to advance in health
Pablo Laguna, new director of the Aragon Engineering Research Institute
III Conference on the Disclosure of Biomedical and Experimental Sciences
Jesús Santamaría new Corresponding Academician of the Royal Canary Academy of Sciences
Non-Hodgkin lymphoma treatment with protein nanoparticles
NANBIOSIS expertise on Nanoparticles Characterization by Amable Bernabé.
A Minimally Invasive Microsensor Specially Designed for Simultaneous Dissolved Oxygen and pH Biofilm Profiling
NANBIOSIS Scientific Director, Jaume Veciana, coauthor of an article highlighted in Chemistry Views
Unit 16 of NANBIOSIS will expand its capabilities with cofinancing of FEDER funds
New inside backcober by researchers of NANBIOSIS U9
CCMIJU: Online Course on INTRODUCTION TO RESEARCH AND LABORATORY TECHNIQUES IN BIOCIENCES
Workshop on “ETHICAL ASPECTS OF RESEARCH”
NANBIOSIS U1 PPP will take a critical role in one of the projects selected by La Marató TV3 to fight against cancer
Killing cancer from starvation or by toxicity with Trojan horses.
“Minimal invasion, maximum innovation”
Best Poster award at the congress of Spanish Society of Nephrology
Formulation of emulsions: Science behind cosmetics at COSMETORIUM
NANBIOSIS AT THE CIBER-BBN ANNUAL CONFERENCE 2019
Biomarkers in semen to diagnose prostate cancer
Nanbiosis and CIBER-BBN present at BioNanoNet and Austrian Microfluidics Initiative (AMI)
Preclinical brain tumour therapy response assessment with MRSI approaches: Oral presentation awarded to Ana Paula Candiota
Not always what closes best opens better: mesoporous nanoparticles capped with organic gates
Biomedicine Project Manager job vacancy
CIBER-BBN Annual Conference 2019
NANBIOSIS Unit 10 expands its equipments and capabilities
Targeting antitumoral proteins to breast cancer by local administration of functional inclusion bodies
NANO TECHNOLOGIES AND MICROENCAPSULATION course
AKT2 as a promising target for future anti-cancer therapies
New publication by scientists of NANBIOSIS Unit 6 aims to motivate scientific community to start a new research line for organic and bio-organic electronics focused on the device fabrication
The Autonomous University of Barcelona, in the elite of the 300 best universities in the world
The University of Zaragoza, in the elite of the 500 best universities in the world
Scientific breakthrough against the problems of advanced age in fertility.
Nanomol group initiates contact with the AEMPS to bring a new treatment against venous leg ulcers to the clinic
Making the most from Signals in Biomedical applications.
NANBIOSIS- OmicsTech: EXPLORING COLLABORATIONS BETWEEN ICTS FACILITIES
Agreement signed with Spanish Goverment for the allocation of FEDER funds for NANBIOSIS ICTS
Judit Tomsen: Best oral presentation at ESC 2019
Do you want to join the nanotechnology revolution?
NANBIOSIS U20 at the Nanomed Europe Conference, NME19.
Agreement signed with Spanish Goverment for the allocation of FEDER funds for NANBIOSIS ICTS
Laparoscopic surgery in the uterus retrieval procedure during uterine transplantation
New Antimicrobial surfaces with self-cleaning properties and NANBIOSIS Unit 17
NANBIOSIS U27 propose a mew method for assessing nonlinear cardiorespiratory interactions
NANBIOSIS unit 13 participation at the VIII Conference of Young Researchers of I3A-UZ
Mechanism of interaction of a material (pharmaceutical, food, construction, chemical, etc.) with moisture or with any organic vapor.
Quantification of Ventricular Repolarization Variation for Sudden Cardiac Death Risk Stratification in Atrial Fibrillation
Preclinical molecular imaging and its application to biomedical research
An Eskimo in the desert
DEVELOPING A SENSOR FRAMEWORK FOR MINIMALLY INVASIVE SURGERY
Multiparametric MR approaches for non-invasive glioblastoma therapy response follow-up (MAGRes)
Job Vacancy for position of Project Manager at CIBER
Safe-N-Medtech kicks off in Bilbao
Diabetes mellitus type 1: new system for treatment
Biomedical devices with natural fluorescence for monitoring in the body
CIBER offers two Degree positions for NANBIOSIS (Project Mananger and Researcher) in the frame of a H2020 project.
The first Nanocomposite that slows the spread of colon cancer
Polymers and medical applications: Success Cases of Preclinical Research
3D cross-correlation dynamic light scattering (DLS) spectrometer of NANBIOSIS U12 has been upgraded
Why peripheral blood lymphocyte alterations can be good biomarkers to predict myocardial infarction severity
New tensiometer for NANBIOSIS Unit 12
Infertility: Exosomal microRNAs in seminal plasma as sensitive and specific biomarkers of the presence of testicular spermatozoa for azoospermia
NANOMOL group, coordinator of NANBIOSIS Unit 6 collaborates with the VHIR in the developement of a new nanomedicine for the treatment of a childhood cancer
Laura Lechuga, Scientific Director of NANBIOSIS Unit 4 is interviewed by CIBER Bulletin
The hidden brain activity
Meshes in a mess: Mesenchymal stem cell-based therapies for soft tissue reinforcement
Nanobiosensors for the monitoring of brain lesions
“Matrioskas” of nanoparticles, a new therapeutic approach against tuberculosis
Micro & nano(bio)technology for Diagnosis: Changes and Challenges
The European Union highlights the relevance of the JUMISC’s Cutting-Edge Infraestructures and Technology, recognized as ICTS.
GLP Analytical Validation Study in Different Animal Species
PILAR MARCO, Scientific Director of NANBIOSIS U2, interviewed by CIBER-BBN ISCIII Bulletin
NANBIOSIS Scientific Women in the International Day of Women and Girls in Science
Label-free bacteria quantification in blood plasma by a bioprinted microarray based interferometric point-of-care device
PICCOLO PROJECT FACE-TO-FACE MEETING
STRYKER & NANBIOSIS start a promising line of biomedical research collaboration
Laura Lechuga, Scientific Director of Unit 4 of NANBIOSIS Coordinates a EuroNanoMed project
NANBIOSIS Against Cancer
Rosa Villa explains how New graphene implants can help to better understand the brain
Cancer metabolism in a snapshot: MRS(I)
Quatsomes. A new family of nanocarriers for drug delivery
New device could monitor treatments with anticoagulant to achive personalized therapies
Bionand, recently incorporated to NANBIOSIS ICTS, among the three national biotechnology reference centers.
Antimicrobial peptides are a promising kind of molecules to fight multi-drug resistant bacteria
Two units of NANBIOSIS in the project selected by La Marató TV3 to fight against bacterial infections
Lysosomal Rare Disorders: Focus on Fabry Disease
BIONAND incorporated to the Spanish ICTS Map as a new node of NANBIOSIS
NANBIOSIS with the research appointment “Towards a New Horizon”
EXPLORING COLLABORATIONS BETWEEN ICTS FACILITIES
NANBIOSIS renews its accreditation as Unique Scientific Technological Infrastructure (ICTS)
NANBIOSIS in the Posters presentation in CIBER-BBN ANNUAL CONFERENCE 2018
Marisa González, Scientific Director of Unit 16 of NANBIOSIS, candidate to the Rectorate of the University of Extremadura
CIBER-BBN Annual Conferences in Valladolid 12-13 November
Update and improvement of unit 20 of NANBIOSIS
Nanomedicine: how to get drugs to the place where they have to act.
Preclinical Study for Brain Tumor with Novel Contrast Agents for MRI
NANBIOSIS resarchers in CCMIJU identify biomarkers for bridging the gap between preclinical studies in large animal models and clinical trials
The revolution of nanomedicine by Ramón Martínez Mañez
FUNCATH: Prevention of infectious diseases with functionalized catheters awarded by La Marató de TV3
NANBIOSIS at the Assembly of Materplat
NANBIOSIS participation in CPhI Worldwide
Nanoparticles characterization techniques of NANBIOSIS unit 6
Researchers of NANBIOSIS U9 awarded for a work on scaffolds for dental regeneration
Ramón Martínez Máñez Master class on Nanomedicine at the Act of the Academic Opening year 2018-2019 of Spanish university
NANBIOSIS participation in BioSpain 2018
Nanoparticles in 3D printed bone prostheses that favor regeneration
Nanbiosis Contribution to biofilm development
CIBER-BBN Annual Conference 2018
Prof. Jaume Veciana, Scientific Director of NANBIOSIS: Olivier Kahn Plenary Lecture speaker at the ICMM 2018
Label-free DNA-methylation detection by direct ds-DNA fragment screening using poly-purine hairpins
JUMISC OBTAINS TWO INTERNATIONAL RECOGNITIONS AT THE ANNUAL MEETING OF THE LAPAROSCOPIC SURGEONS SOCIETY HELD IN NEW YORK
A new pathway for the prevention of metastasis in colorectal cancer in humans is open: a nanomedicine that selectively eliminates metastatic stem cells
NANBIOSIS Unit 27 at VPH2018: VIRTUAL PHYSIOLOGICAL HUMAN 2018
Nanoplasmonic biosensor device for the monitoring of acenocoumarol therapeutic drug in plasma
COURSE FOR THE PERFORMANCE OF FUNCTIONS A, B AND C IN RODENTS, LAGOMORFOS, CARNIVORES, PIGS AND SMALL RUMINANTS
Recombinant proteins production: optimization strategies.
Conversion of Biomolecules into pharmaceuticas Leads using nanovesicles
Peptides, targeting units and drug conjugates
Advanced methods of continuous production of Nanomaterials
Micro and nanotechnologies for the release of biotechnological products
Nanoparticle uptake and in vivo estimates of therapeutic efect and toxicity
Biodistribution, safety and efficacy studies of pharmacological release nanotechnological systems
Use of Nanomedicine in preclinical studies and animal models
Testing medical devices and drugs GLP Compliance
NANBIOSIS develops on demand projects and cutting edge biomedical solutions.
NANBIOSIS Youtube channel: new video-presentations and informative capsules about NANBIOSIS activity
Manuel Souto received UAB PhD Extraordinary Award
Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
How to optimize strategies to produce recombinant proteins?
Nanopatterns of Surface-Bound EphrinB1 Produce Multivalent Ligand–Receptor Interactions That Tune EphB2 Receptor Clustering
Science and welfare of the Laboratory animal: New theorical and practical course by JUMISC
The PRO-NANBIOSIS II Network of Excellence begins its execution
Advanced encapsulation technologies
Artificial 3D Culture Systems for T Cell Expansion
Nano-carrier to release drugs into damaged cells
Strong Ministerial Support to NANBIOSIS ICTS
Resemblance of the human liver sinusoid in a fluidic device with biomedical and pharmaceutical applications
The general consul of France meets with NANBIOSIS researchers
Interferometric nanoimmunosensor for label-free and real-time monitoring of Irgarol 1051 in seawater
Nanomedicine to fight against the spread of cancer
Seminal plasma influences the fertilizing potential of cryopreserved stallion sperm
NANBIOSIS researcher Iñaki Ochoa, interviewed in the Heraldo de Aragón criticizes the administrative obstacles to science imposed by law.
Gold/Silver/Gold Trilayer Films On Nanostructured Polycarbonate Substrates For Direct And Label‐Free Nanoplasmonic Biosensing
Mimicking physiological O2 tension in the female reproductive tract improves assisted reproduction outcomes in pig
Manuel Doblaré, Unit 13 of NANBIOSIS, SEMNI Award O. C. Zienkiewicz
JUMISC, partner of NANBIOSIS has hosted PICCOLO Project Face-to-Face Meeting.
Jesús Santamaría, interviewed in the Cadena Ser Radio, denounces the bureaucratic barriers that hinder research.
Biomaterials as signal-releasing platforms
NANBIOSIS Unit 14 of Cell Therapy receives the Research Excellence Accreditation
New cover ACS Sustainable Che. Eng. by Scientists of NANBOSIS U9
Stimuli-Responsive Functionalization Strategies to Spatially and Temporally Control Surface Properties: Michael vs Diels–Alder Type Additions
Josep Samitier, Scientific Director of NANBIOSIS Unit 7, Panelist in a round table about the current situation of biomedical research
Judith Guasch, (NANBIOSIS Unit 6) has been granted with a Ramon y Cajal grant from the Spanish Goverment
«The combination of nanotechnology with bioengineering and biomedicine allows us to act on the human body on a molecular scale»
Parasympathetic tone activity evaluation to discriminate ketorolac and ketorolac/tramadol analgesia level in swine
Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin
Prof. Laura Lehuga, new Associate Editor at Analyst Editorial Board
Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs
Graphene 2018 with the participation of NANBIOSIS Unit 8
Release of targeted protein nanoparticles from functional bacterial amyloids: A death star-like approach
Online oxygen monitoring using integrated inkjetprinted sensors in a liver-on-a-chip system
Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides
Nanoligent obtains the first prize in the Tech Transfer Competition in the ONCO Emergence forum
Esther Pueyo, NANBIOSIS U 27, at the 3rd Barcelona VPH Summer School
Nanoligent, the spin off created by the Directors of Units 1 and 18 of NANBIOSIS, awarded for the best company in Health Sciences given by the law firm RCD
A CO2 optical sensor based on self-assembled metal–organic framework nanoparticles
NANOMEDICINE APPLICATIONS IN DRUG DELIVERY AND TARGETING: NANBIOSIS – NANOMED Industrial Forum
Infections such as Candiasis will be detected in 30 minutes
NANBIOSIS working on the development of next generation catheters
Institutional impulse to accelerate 3D printing projects
Intestinal histopathological changes in a porcine model of pneumoperitoneum-induced intra-abdominal hypertension
Why research in micro-electronics? Neural interfaces, interaction between the nervous and the artificial system
Interpretation of motion analysis of laparoscopic instruments based on principal component analysis in box trainer settings
NANBIOSIS U2 incorporates a new Nitrogen tank to store cells
Graphene will be manufactured with greater economic and biomedical benefits at NANBIOSIS unit 8
Update and improvement of unit 4 of NANBIOSIS
New laboratory for unit 6 of NANBIOSIS
NANBIOSIS Unit 20 expands its equipments and capabilities
Evaluation of a New Design of Antireflux-Biodegradable Ureteral Stent in Animal Model
SINO-SPAIN Biomedical and Pharmaceutical Conference with NANBIOSIS participation
Photonic Label-Free Biosensors for Real-Time Analysis of Untreated Clinical and Environmental Samples
NANOLIGENT, the first drug designed to eliminate metastases stem cells
Rey Jaime I Award of New Technologies to Ramón Martínez Mañez
A dressing with active ingredients to regenerate skin wounds
Agreements signed with MINECO for the allocation of FEDER funds for NANBIOSIS ICTS
Adipose-Derived Stem Cells Ameliorates Ischemia-Reperfusion Injury in a Rat Skin Free Flap Model
DRIVE Project: Artificial Biopancreas for Type I Diabetics
Effect of Surface Chemistry and Associated Protein Corona on the Long-Term Biodegradation of Iron Oxide Nanoparticles In Vivo
Relevant research results for assisted reproduction.
20th European Conference on Integrated Optics
NANBIOSIS participation at VII Conference of Young Researchers of I3A