Located in the Faculty of Medicine of the University of Valencia (UV) has a laboratory with a NMR (14T) for acquiring unique metabolic profiles of biofluids, cell lines and tissues. This Unit is coordinated by Dr. Ramón Martínez Máñez, PI of the Applied Molecular Chemistry Group of the Universidad Politécnica de Valencia, together with Dr. Salvador Gil, Director of the Central Service for Experimental Research (SCSIE).
Ramon Martínez Máñez, Scientific Director of Unit 26 of NANBIOSIS, has participated in the development, on a laboratory scale, of a low cost device for treatments based on the application of optical hyperthermia by laser. Among the applications of this technique are the therapies against cutaneous cancer and its objective is to get the death of the tumour cells by overheating. Overheating is achieved by the irradiation of synthesized metal nanoparticles. The prototype developed consists of an infrared laser with a power of up to 500mW able to provide a power density of up to 4W / cm2, a sensor[...]
Researchers of Unit 26 of NANBIOSIS participate in the design and evaluation of the cellular level of a new hybrid material for the creation of intelligent-scaffolds implants that open the door to a more efficient treatment of infections and bone tumors. The main novelty is the incorporation of a mesoporous matrix of silicon, calcium and phosphorus oxides, with molecular gates that would allow the controlled release of substances stored inside the pores, such as antitumor drugs or antibiotics. A molecular gate is a mechanism whose opening depends on certain external stimuli, in this particular case the drugs would only b[...]
Researchers of the Universitat Politècnica de València (UPV), the Universitat Rovira i Virgili (URV) and CIBER of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) have developed new nanodevices to detect the presence of cocaine in saliva or in any another aqueous solution. Part of the characterization of the probe was carried out using NMR facilities from NANBIOSIS. The paper is published in the journal Scientific Reports, of the group Nature. The development consists of a molecular gate designed with nanoporous alumina, an aluminum oxide prepared by electrochemical means with pores of micrometric diameter. “A molecular gate -explains Ramón Martínez-Máñez, scientific director of[...]
The University of Zaragoza is one of the 200 best universities in the world in science research, according to the latest Shanghai ranking of 2016 in a specific analysis by macro areas. In order to elaborate this ranking by macroareas indicators such as the number of students and professors who have obtained the Nobel prize or Fields medal, the number of researchers highly cited in the scientific literature, the number of scientific articles indexed in the Science Citation Index and the Percentage of articles published in the most cited 20% scientific journals are used. Only six Spanish universities are among[...]
Ramon Martínez Máñez, Scientific Director of the Unit 26 of NANBIOSIS, together with researchers from his group and the group led by Professor Liz Marzal, both CIBER-BBN groups, have developed a new method to detect cocaine and Mycoplasma in very low concentrations. The method involves the combined use of mesoporous silica nanoparticles, molecular equipped with doors, and spectroscopy SERS (Surface-Enhanced Raman Scattering) a signal amplification system that uses gold nanoparticles to detect very low concentrations of the substances tested. According to the tests that have been developed in the laboratory, in the case of cocaine it has allowed them to[...]
The Governing Board of the Spanish Royal Society of Chemistry (SRSQ) has agreed to grant its Research Excellence Award 2016 to Dr. Ramón Martínez Máñez, Scientific Director of Unit 26 of NANBIOSIS and Scientific Director of CIBER-BBN, in recognition of the quality and innovation of its research in the design of chrome-fluorogenic detection probes and the development of new delivery systems and their impact on biomedical applications. Martinez Máñez is co-authored of more than 330 scientific publications in international journals. His scientific work has been cited on over 13,000 occasions. It is among the 15 most cited authors in t[...]
So far, the work has focused on cellular assays, with positive results, that could open new ways to improve the effectiveness of some drugs used in the treatment of breast cancer. The main novelty of these nanodevices is that the molecule covering the nanodevice not only controls when the transported drugs are released, but also controls where they are released to direct them to cells expressing TLR3, a protein of the innate immune system overexpressed in some cell lines of breast cancer. Through this protein it is also launched a death signal that ends with the tumor cell. Their study[...]