This platform is coordinated by Dr. E. Peña member of the Applied Mechanics and Bioengineering Group of the Aragón Institute of Engineering Research (I3A) at the University of Zaragoza. The objective of this unit is to provide services for structural and physical characterization of biological tissues and tissue scaffolding, including microstructure, histology and mechanical tests among others. This platform, unique in Spain as regarding its capability, has a clear and direct translational impact, especially in regenerative medicine, implant design and evaluation, as well as in the study of the mechanical behavior of living tissues (especially in the musculoskeletal and cardiovascular systems). Its relationship with the Instituto Aragonés de Ciencias de la Salud (Health Sciences Institute of Aragon), and through it with the Tissue and Blood Bank of Aragon and with the School of Veterinary Science at the Universidad de Zaragoza, allows an easy provision of tissues both from animals (mice, rabbit, sheep, pig) and humans, following in their handling the recommendations of the different ethics committees.
It has several types of INSTRON testing machines specializedin biological tissues, for the characterizationof soft tissues and fibers, as well as an X-ray microCT which allows quantitatively characterizing the microstructure of in vitro samples of hard tissues and of biomaterials for scaffolds. It also has the entire system necessary for performing high-quality histologies which would complete the structural characterization of the previously cited types of tissues (staining of preparations, immunohistochemistry in paraffin with EnVision, laser microdissection, etc.). As additional tests, equipment for determining the permeability of biological tissues and scaffolds under culture conditions, monitoring their variation over time is also available. Finally, the platform is also composed of different types of bioreactors, including perfusion or direct compression on seeded scaffolds for stimulating cell cultures for tissue engineering applications.
FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE
Researchers of the NANBIOSIS U13 apply numerical models to the cornea to better understand how it behaves and help in surgical planning. Data and algorithms developed through the computer, together with the 3D image, make it easier for ophthalmologists to perform eye surgery more precise and personalized treatments for each patient The work carried out by Miguel Ángel Ariza Gracia at the Aragón Engineering Research Institute (I3A) has been recognized by the University of Zaragoza with the Extraordinary Award for the Best Doctoral Thesis of the Biomedical Engineering Program in 2017 In this line of research, framed in the European[...]
On February 22nd, the National School of Health of the Carlos III Health Institute hosted the forum on Smart Biomaterials and biomedical devices for applications in drug delivery and regenerative medicine, organized by the ICTS Nanbiosis, an infrastructure shared by the CIBER-BBN and the Center of Minimally Invasive Surgery Jesus Usón (CCMIJU). This is the first groups/companies meeting organized by Nanbiosis, in which about 70 B2B meetings were held. The meeting brought together about 40 participants from 14 research groups (from the CIBER-BBN and the CCMIJU) and 10 companies, which discussed the latest advances in the research lines developed by the groups[...]
The research group coordinating NANBIOSIS Unit 13 is the Spanish group of the European project ORCHID (Organ-On-Chip In Development). The scientists of Engineering Research Institute (I3A) and CIBER-BBN, Luis Fernández and Iñaki Ochoa, will work on this project whose objective is to accelerate the social and economic impact of the technology known as Organ-on-Chip. This technology based on the use of microfluidic platforms is already facilitating the discovery of drugs, but it can go a step further with applications in personalized medicine and safety pharmacology and that, in addition, offers alternatives to conventional tests in animals. The mechanical properties and[...]
Last 13 and 14 of November, CIBER-BBN has celebrated its 11th Annual Conference in Hotel Santemar in Santander. In this conference there was a poster session with the participation of the following Units of NANBIOSIS. Special mention deserves Unit 1 with Neus Ferrer as Director and Paolo Saccardo as Coordinator (in the picture): Posters: U1. Protein Production Platform (PPP): Engineering protein complexes as nano- or micro-structured vehicles or drugs for human and veterinary medicine. Ugutz Unzueta, Naroa Serna, Laura Sánchez-García, José Vicente Carratalá, Olivia Cano-Garrido, Mercedes Márquez, Paolo Saccardo, Rosa Mendoza, Raquel Díaz, Héctor, López-Laguna, Julieta Sánchez, Anna Obando, Amanda Muñoz, Andrés Cisneros, Eric Voltà, Aida Carreño, José[...]
On June 2, the VI Conference of Young Researchers organized by the I3A at the University of Zaragoza was held, aimed at doctoral students who have as director or co-director an I3A member. The inaugural lecture was given by José Antonio Sanz Herrera (Professor Contractor Doctor at the University of Seville and who held his doctorate at I3A) who has talked about Multidisciplinary Research as the basis of the young professor in engineering. After the inaugural conference a first block was opened with four oral presentations, giving way to the poster session and coffee. A second and final block wit[...]
Estefanía Peña, Scientific Coordinator of Unit 13 of NANBIOSIS explains her resarch in the program “En route with science” of Aragon Television. Bioengineering consists in the application of the principles of engineering to the field of medicine. In the opinion of Estefanía, coordinator of the Division of Biomedical Engineering and deputy director of I3A (Institute of Research in Engineering of Aragon) Bioingineering is being strengthened in Spain. “Our research develops mathematical models and computational reproduction, especially of cardiovascular diseases and the therapies to solve them. Fundamentally we work on atherosclerosis, which is the appearance and development of atheroma plaque (a cluster of[...]
María Virumbrales, PhD candidate in the research group coordinating of Unit 13 of NANBIOSIS, has been awarded the Prize to the Best Oral Presentation in the I National Congress for Young Researchers in Biomedicine, which took place in Valencia, Spain, on the 28th-29th of November, 2016. The title of the communication was: “Tubeless microfluidic device to mimic tumor microenvironment and monitor cancer-endothelium interactions”. The talk described an in vitro 3D model closely resembling biological tissues and blood vessels, established within a biocompatible material. This model is currently being used to recreate breast tumor microenvironment and evaluate drug efficiency within. [...]
Scientist of NANBIOSIS in collaboration with other CIBER-BBN researchers have developed a sophisticated microfluidic biomedicine device capable of reproducing in vitro and by 3D bioprinting the complexity of different tumour types. This device allows tumour cells to grow in a 3D environment where nutrients and oxygen are supplied in a controlled way through small capillaries, thus mimicking the body’s own blood vessels. Thanks to this new technology, it is now possible to reproduce in a controlled way all the processes of the tumour environment, which could help to develop new treatments and combinations of drugs that are more effective for[...]