This platform is coordinated by Dr. E. Peña member of the Applied Mechanics and Bioengineering Group of the Aragón Institute of Engineering Research (I3A) at the University of Zaragoza. The objective of this unit is to provide services for structural and physical characterization of biological tissues and tissue scaffolding, including microstructure, histology and mechanical tests among others. This platform, unique in Spain as regarding its capability, has a clear and direct translational impact, especially in regenerative medicine, implant design and evaluation, as well as in the study of the mechanical behavior of living tissues (especially in the musculoskeletal and cardiovascular systems). Its relationship with the Instituto Aragonés de Ciencias de la Salud (Health Sciences Institute of Aragon), and through it with the Tissue and Blood Bank of Aragon and with the School of Veterinary Science at the Universidad de Zaragoza, allows an easy provision of tissues both from animals (mice, rabbit, sheep, pig) and humans, following in their handling the recommendations of the different ethics committees.
It has several types of INSTRON testing machines specializedin biological tissues, for the characterizationof soft tissues and fibers, as well as an X-ray microCT which allows quantitatively characterizing the microstructure of in vitro samples of hard tissues and of biomaterials for scaffolds. It also has the entire system necessary for performing high-quality histologies which would complete the structural characterization of the previously cited types of tissues (staining of preparations, immunohistochemistry in paraffin with EnVision, laser microdissection, etc.). As additional tests, equipment for determining the permeability of biological tissues and scaffolds under culture conditions, monitoring their variation over time is also available. Finally, the platform is also composed of different types of bioreactors, including perfusion or direct compression on seeded scaffolds for stimulating cell cultures for tissue engineering applications.
Estefanía Peña, Scientific Coordinator of Unit 13 of NANBIOSIS explains her resarch in the program “En route with science” of Aragon Television. Bioengineering consists in the application of the principles of engineering to the field of medicine. In the opinion of Estefanía, coordinator of the Division of Biomedical Engineering and deputy director of I3A (Institute of Research in Engineering of Aragon) Bioingineering is being strengthened in Spain. “Our research develops mathematical models and computational reproduction, especially of cardiovascular diseases and the therapies to solve them. Fundamentally we work on atherosclerosis, which is the appearance and development of atheroma plaque (a cluster of[...]
María Virumbrales, PhD candidate in the research group coordinating of Unit 13 of NANBIOSIS, has been awarded the Prize to the Best Oral Presentation in the I National Congress for Young Researchers in Biomedicine, which took place in Valencia, Spain, on the 28th-29th of November, 2016. The title of the communication was: “Tubeless microfluidic device to mimic tumor microenvironment and monitor cancer-endothelium interactions”. The talk described an in vitro 3D model closely resembling biological tissues and blood vessels, established within a biocompatible material. This model is currently being used to recreate breast tumor microenvironment and evaluate drug efficiency within. [...]
Scientist of NANBIOSIS in collaboration with other CIBER-BBN researchers have developed a sophisticated microfluidic biomedicine device capable of reproducing in vitro and by 3D bioprinting the complexity of different tumour types. This device allows tumour cells to grow in a 3D environment where nutrients and oxygen are supplied in a controlled way through small capillaries, thus mimicking the body’s own blood vessels. Thanks to this new technology, it is now possible to reproduce in a controlled way all the processes of the tumour environment, which could help to develop new treatments and combinations of drugs that are more effective for[...]
The University of Zaragoza is one of the 200 best universities in the world in science research, according to the latest Shanghai ranking of 2016 in a specific analysis by macro areas. In order to elaborate this ranking by macroareas indicators such as the number of students and professors who have obtained the Nobel prize or Fields medal, the number of researchers highly cited in the scientific literature, the number of scientific articles indexed in the Science Citation Index and the Percentage of articles published in the most cited 20% scientific journals are used. Only six Spanish universities are among[...]