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U6. Biomaterial Processing and Nanostructuring Unit

Ciber bbn

U6. Biomaterial Processing and Nanostructuring Unit

  • Scientific Coordinator: Dr. Santi Sala sala@icmab.es
  • Entities: Instituto de Ciencia de Materiales de Barcelona ICMAB-CSIC
  • Address: Campus de UAB, 08193, Bellaterra, Barcelona, Spain
  • Phone: +34 935 801 853
  • Fax: +34 935 805 729
  • Web: ICMAB
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Description

Located at the Instituto de Ciencia de Materiales de Barcelona (ICMAB-CSIC), in Barcelona, and under the coordination of Professor Jaume Veciana, current director of NANOMOL Group, gathers several laboratories to perform the mission of this facility: the characterization, development and large-scale production ofmolecular biomaterials of therapeutic or biomedical interest, with controlled micro-, nano- and supramolecular structure.
This unit is composed of the equipment and the scientific and technical personnel to develop and apply efficient, robust and green technologies based on the use of supercritical fluids (or dense gases), such as compressed CO2. The main activity of this unit is focused on the production of pure micro- and nanoparticulate active therapeutic ingredients and passive or active therapeutic nanoconjugates (vesicles, liposomes, nanosuspensions, micro- and nanostructured polymeric particles), as well as porous matrices of biocompatible polymers for tissue engineering or implants. The unit has also instruments and the necessary know-how to undertake nanostructuring of molecular biomaterials in films and surfaces, with application in the development of new biomedical devices. The facilities are equipped with laboratory and pre-pilot scale plants, high pressure phase analyzers and analytical instrumentation for micro- and nanoparticle physico-chemical characterization (particle size distribution, particle concentration, particle morphology and stability, Z-potential). One of the singularities of this unit is that counts with plants at different scales, from mL to L, which allow process development by QbD and process scale-up.
 
U6. Services & Rates

News U6

21 Dec

Validation of a drug for foot ulcers in collaboration with Cuba
Validation of a drug for foot ulcers in collaboration with Cuba

Nanomol, (Unit 6 of NANBIOSIS) has announced in Cuba that the process of clinical validation of a new drug developed and patented in collaboration with Center of Genetic Engineering and Biotechnology of Cuba, integrated in BioCubaFarma, has been initiated. The new drug is designed to improve the healing of foot ulcer in diabetics and could be on the market in five years. The collaboration of the Center for Genetic Engineering and Biotechnology of Cuba with Nanomol, coordinating group of Unit 6 of NANBIOSIS, began in 2010. Cuban researchers had developed an effective product in wound healing in diabetics but t[...]

16 Dec

Lipid-based Nanovesicles for Nanomedicine
Lipid-based Nanovesicles for Nanomedicine

Jaume Veciana and Nora Ventosa, Scientific Directors of Unit 6 of NANBIOSIS together with other researchers from NANOMOL group, coordinator of Unit 6 of NANBIOSIS, has recently published an interesting review article in the journal Chemical Society Reviews. This review presents the large plethora of lipid-based nanovescicles available nowadays, focusing on a new generation of non-liposomal L-NVs and showing their similarities and differences with respect to their ancestors (liposomes). Since the overspread of a nanomaterial to the market is also strongly dependent on the availability of technological-scale preparation methods, it also extensively review the current approaches exploited for L-NV production. T[...]

22 Nov

Extraordinary doctoral award
Extraordinary doctoral award

Ingrid Cabrera, member of the NANOMOL group that coordinates Unit 6 of NANBIOSIS, has obtained the extraordinary doctoral award from the Universitat Autònoma de Barcelona for her thesis “Nanovesicle-bioactive conjugates to be used as nanomedicines, prepared by a one-step scalable method Using CO₂-expanded solvents“. This thesis was directed by Jaume Veciana, Scientific Director of NANBIOSIS and Nora Ventosa, Scientific Director of Unit 6 of NANBIOSIS. The main objectives of the  PhD Thesis of Dr. Ingrid Cabrera were the preparation and study of multifunctional nanovesicle based nanoformulation of alfa-galactosidase for the treatment of Fabry desease as well as of another multifunctiona[...]

26 Oct

Congress Excellence 2016
Congress Excellence 2016

The Spanish University with the highest number of scientifically distinguished research institutes is Universitat Autònoma de Barcelona with five Centres of Excellence “Severo Ochoa” and two Units of Excellence “María de Maeztu”. ICMAB-CSIC, Research Institute housing unit 6 of NANBIOSIS and one of the five Severo Ochoa Centers of UAB organised the Congress Excellence 2016 More information[...]

09 Sep

Nanbiosis-U6-Chemical control over the energy-level alignment in a two-terminal junction
Chemical control over the energy-level alignment in a two-terminal junction

In a study published in the journal Nature Communications, researchers of Nanomol group, led by the Scientific Director of Unit 6 of NANBIOSIS, Dr. Jaume Veciana have shown that the alignment of the energy levels in molecular bonds based on sel- assembled monolayers can be regulated through only chemical modifications. The energy-level alignment of molecular transistors can be controlled by external gating to move molecular orbitals with respect to the Fermi levels of the source and drain electrodes. Two-terminal molecular tunnelling junctions, however, lack a gate electrode and suffer from Fermi-level pinning, making it difficult to control the energy-level alignment[...]

27 Jul

Synergies produced in NANBIOSIS multiply the value of its services and allow its users to have results with faster and superior reliability due to proven experience of the scientists and technicians involved, says Jaume Veciana, Scientific Director of NANBIOSIS, in an interview at July 2016 CIBER-BBN Bulletin.
Synergies produced in NANBIOSIS multiply the value of its services and allow its users to have results with faster and superior reliability due to proven experience of the scientists and technicians involved, says Jaume Veciana, Scientific Director of NANBIOSIS, in an interview at July 2016 CIBER-BBN Bulletin.

In this interview, Jaume Veciana assesses the functioning of this Singular Scientific-Technical Infrastructure and its contribution to research and anticipates some of the guidelines of the NANBIOSIS Strategic Plan 2017-2020, which includes a clear commitment to internationalization. “The scientific-technical capabilities available at NANBIOSIS must be exploited without limitation to our country. Therefore we are clear that we must promote the activity of NANBIOSIS both academic and industrial sector in the European Union and other countries, either directly or in association with other similar organizations actions. Some such initiatives have already started but we believe it should be given further boost[...]

28 Jun

“a-Galactosidase A Loaded Nanoliposomes with Enhanced Enzymatic Activity and Intracellular Penetration”
“a-Galactosidase A Loaded Nanoliposomes with Enhanced Enzymatic Activity and Intracellular Penetration”

Unit 1 of NANBIOSIS, Protein Production Platform (PPP), Unit 3, Synthesis of Peptides, Unit 20, In Vivo Experimental Platform and Unit 6, Biomaterial Processing and Nanostructuring Unit, have jointly developed the research conducted in relation with a CO2-based methodology for the one-step production of protein-nanoliposome conjugates as bio-active nanomaterials with therapeutic interest. The results have been published in Advanced Healthcare Materials: http://www.ncbi.nlm.nih.gov/pubmed/26890358 “a-Galactosidase A Loaded Nanoliposomes with Enhanced Enzymatic Activity and Intracellular Penetration I. Cabrera, I. Abasolo, J. L. Corchero, E. Elizondo,  P. Rivera, E. Moreno, J. Faraudo, S. Sala, D. Bueno, E. González-Mira, M. Rivas, M. Melgarejo, D. Pulido,[...]

11 Apr

Nanbiosis-U6 -NANOMOL-CSIC of CIBER-BBN accredited with TECNIO seal
NANOMOL-CSIC of CIBER-BBN is one of the 54 accredited institutions in Catalonia with the new TECNIO seal

At an event held on April 7th 2016 chaired by Hon. Mr. Jordi Baiget, Minister for Business and Enterprise of the Generalitat of Catalonia, were presented the first 54 organizations accredited with the TECNIO seal; one of which was NANOMOL-CSIC, the research group of CIBER-BBN coordinating Unit 6 of NANBIOSIS. The accreditation is the hallmark TECNIO granted by the Government of Catalonia, through ACCIÓ to identify the developers and facilitators of differential technologies in Catalonia.[...]

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