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U6. Biomaterial Processing and Nanostructuring Unit

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U6. Biomaterial Processing and Nanostructuring Unit




    • Scientific Coordinator: Dr. Nathaly Segovia nvsegovia@icmab.es
    • Entities: Instituto de Ciencia de Materiales de Barcelona ICMAB-CSIC
    • Address: Campus de UAB, 08193, Bellaterra, Barcelona, Spain
    • Phone: +34 935 801 853
    • Fax: +34 935 805 729
    • Web: ICMAB








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Located at the Instituto de Ciencia de Materiales de Barcelona (ICMAB-CSIC), in Barcelona, and under the coordination of Professor Jaume Veciana and Prof. Nora Ventosa, current directors of NANOMOL Group, which is a research group with wide expertise and recognized excellence in the synthesis, processing and study of molecular and polymeric materials with chemical, electronic, magnetic and biomedical properties.  It gathers several laboratories, perfectly equipped, to perform the mission of this facility: the development, characterization, and large-scale production of molecular biomaterials of therapeutic or biomedical interest, with controlled micro-, nano- and supramolecular structure. One example of Key-Enabling-Technology (KET) available in this unit is a simple one-step methodology, DELOS-SUSP, based on the use of compressed fluids (CF), such as CO2, to prepare particulate materials with precise and reproducible structural characteristics at micro-, nano- and supramolecular levels (size, shape, internal structural gradients, supra­molecular organization and crystalline purity). This example shows one of the singularities of this unit is that counts with CF–based plants at different scales, from mL to L, which allow process development by QbD and process scale-up.


U6. Services & Rates

Active projects

TitleFundin: OrganismCall: Funding source Role
GA: 720942SMART FUNCTIONAL GLA-NANOFORMULATION FOR FABRY DISEASE – Smart-4-FabryUnión Europea (Comisión Europea)H2020-NMBP-2016-2017Coordinator
SAF2017-90810-REDIStrategic Promotion and coordinated management of Nanbiosis: Pronanbiosis IIAgencia Estatal de Investigación (AEI)Acciones de dinamización «REDES DE EXCELENCIA» -ICTS 2017Coordinator

Other projects

RefTitleFunding OrganismUnit Role
PI15/00272Design of intelligent nanoconjugates for the treatment of metastatic colorectal cancer.Instituto de Salud Carlos IIIParticipant
H2020-MSCA-ITN-2014-642196Integrated self-assembled SWITCHable systems and materials: towards responsive organic electronics - a multi-site innovative training action i-SwitchUnión Europea H2020Participant
2014 SGR 17Consolidation Research Group: Molecular Nanociènciai Materials Orgànics (NANOMOL)Generalitat de CatalunyaParticipant
CTQ2013-40480-RMolecular Bio- and Electro-active materials for the improvement of health and social well-being (Be-Well)MICINNParticipant
FP7-PEOPLE-2013-ITN nº 607721Nanochemistry of molecular materials for 2-photon functional applications. Nano2FunUnión EuropeaParticipant
MAT2013-50036-EXPCell Surface Vessel Engineering Using Dynamic Molecular Bioinfecting (DYNAMO)MINECOParticipant
RTC-2016-4567-1Nanocapsules containing active ingredients for the topical treatment of dermatological diseases (NANO4DERM)MINECOParticipant
RTC-2014-2183-SApplication of Quatsomes technology for the development of a new range of perfumed softeners with lower environmental impactMINECOParticipant
201260E080Self-assembly, Nanostructuring and Processing of Functional Organic Molecules and their ApplicationsMinisterio de Ciencia e InnovaciónParticipant
MAT2016-80826-RMolecular materials and supramolecular organizations for therapy, diagnosis and tissue engineering (MOTHER)MINECOParticipant
RTC-2014-2207-1TERARMET: Development of therapies for the treatment of rare congenital metabolic diseasesMINECOParticipant




  • Munoz-Gomez J.L., Monteagudo E., Lloveras V., Parella T., Veciana J., Vidal-Gancedo J.. Optimized polarization build-up times in dissolution DNP-NMR using a benzyl amino derivative of BDPA. RSC Advances. 2016;6(32):27077-27082.
  • Cordoba A., Hierro-Oliva M., Pacha-Olivenza M.A., Fernandez-Calderon M.C., Perello J., Isern B. et al. Direct Covalent Grafting of Phytate to Titanium Surfaces through Ti-O-P Bonding Shows Bone Stimulating Surface Properties and Decreased Bacterial Adhesion. ACS Applied Materials and Interfaces. 2016;8(18):11326-11335.
  • Cabrera I., Abasolo I., Corchero J.L., Elizondo E., Gil P.R., Moreno E. et al. α-Galactosidase-A Loaded-Nanoliposomes with Enhanced Enzymatic Activity and Intracellular Penetration. Advanced Healthcare Materials. 2016;5(7):829-840.
  • Cano-Garrido O., Sanchez-Chardi A., Pares S., Giro I., Tatkiewicz W.I., Ferrer-Miralles N. et al. Functional protein-based nanomaterial produced in microorganisms recognized as safe: A new platform for biotechnology. Acta Biomaterialia. 2016;43:230-239.

News U6

16 Oct

Biomarkers in semen to diagnose prostate cancer

Sara Larriba of the Human Molecular Genetics Group of Bellvitge Biomedical Research Institute (IDIBELL) has informed NANBIOSIS about a recent publication mentioning NANBIOSIS in the Acknowledgements for its participation in the results of their research. (The nanoparticle tracking analysis was performed by the ICTS NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit) The article has been published by the journal Scientific Reports of Nature Research. The prediction of PCa in the early stage of the disease is one of the most important objectives in male urology. A significant decrease in deaths due to PCa has been associated with the use of serum[...]

23 Aug

Targeting antitumoral proteins to breast cancer by local administration of functional inclusion bodies

Three units of NANBIOSIS have collaborated in obtaining the research results published in the article “Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies” published by Advanced Science Protein production and DLS have been partially performed by the Unit 1 of ICTS NANBIOSIS Protein Production Platform (PPP) and the Unit 6 NANBIOBIS Biomaterial Processing and Nanostructuring Unit. Biodistribution and immunohistochemistry assays were performed at NANBIOSIS U20 In Vivo Experimental Platform/FVPR Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44‐targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types[...]

20 Aug

New publication by scientists of NANBIOSIS Unit 6 aims to motivate scientific community to start a new research line for organic and bio-organic electronics focused on the device fabrication

Researchers of Nanomol Group, coordinator of NANBIOSIS U6 of CIBER-BBN and ICMAB-CSIC, led by Inma Ratera and Jaume Veciana have publish a new article titled “Reversible switching of the Au(111) work function by near infrared irradiation with a bistable SAM based on a radical donor–acceptor dyad“, at Journal of Materials Chemistry C. Article: https://pubs.rsc.org/en/content/articlelanding/2019/TC/C9TC00906J#!divAbstract[...]

30 Jul

Nanomol group initiates contact with the AEMPS to bring a new treatment against venous leg ulcers to the clinic

Researchers of the Nanomol group, ICMAB-CSIC and CIBER-BBN members of the ICTS “NANBIOSIS”, specifically of the Biomaterial Processing and Nanostructuring unit (U6), together with the company Nanomol Technologies S.L. have begun a consultation process with the Spanish Association of Medicines and Health Products (AEMPS) to try and enter a new treatment in a clinical studies stage, to fight against venous ulcers in lower extremities. The study is carried out within the framework of the RIS3CAT NANONAFRES project. Approximately, 80% of ulcers in lower extremities have associated pathologies of venous insufficiency and these wounds are usually recurrent. An open ulcer can[...]

27 Jun

Judit Tomsen: Best oral presentation at ESC 2019

Last June 18-22 at the 2019, ESC meeting, the European Students Colloid Conference, that took place in Varna, Bulgaria, Judit Tomsen,  PhD fellow at the Nanomol group from CIBER-BBN and ICMAB-CSIC, was awarded with the best oral presentation. Judit Tomsen, who carries out her work under supervision of Nora Ventosa,  Scientific Director of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit, presented her oral communication entitled “Design of peptide targeted nanovesicles for the α-galactosidase A enzyme delivery“. Her talk explained some of the smart4fabry european project results, a project coordinated by CIBER-BBN and Nora Ventosa in which participates NANBIOSIS Unit 6. The European Colloids and Interfaces Society (ECIS) organizes biannually ESC meetings of advanced students at PhD and MSc[...]

29 May

Mechanism of interaction of a material (pharmaceutical, food, construction, chemical, etc.) with moisture or with any organic vapor.

Next June 11, 2019, from 09:30h to 17:00h, will take place in Eureka Building – Parc de Recerca, UAB (Barcelona), a Scientific-Theoretical / Practical Workshop on: DYNAMIC SORPTION OF VAPORS (DVS – DYNAMIC VAPOR SORPTION) AND CHARACTERIZATION OF MATERIALS (iGC / SEA – INVERSE GAS CHROMATOGRAPHY / SURFACE ENERGY ANALYZER) FOR THE ANALYSIS OF THE SORTION OF WATER AND ORGANIC VAPORS, AND CHARACTERIZATION OF MATERIALS AND SURFACES. The event is organized by IESMAT, S.A. in collaboration with Nanomol Technologies SL, the Institute of Materials Science of Barcelona (ICMAB-CSIC), Surface Measurement Systems (SMS) and the Center for Biomedical Research in Network[...]

09 Apr

Infertility: Exosomal microRNAs in seminal plasma as sensitive and specific biomarkers of the presence of testicular spermatozoa for azoospermia

NANBIOSIS ICTS coordination equipment has recently received from researchers of Human Molecular Genetics Group of Bellvitge Biomedical Research Institute (IDIBELL) a publication mentioning NANBIOSIS in the Acknowledgements for its participation in the results of its investigations. The article has been publish by the journal Human Reproduction of OXFORD UNIV PRESS  with Quartile 1/ Decile 1. The study carried out by  Maria Barcelo, Ana Mata, Lluís Bassas, and Sara Larriba demonstrates the potential of several miRNAs contained in small extracellular vesicles (sEVs) of seminal fluid as sensitive and specific biomarkers for selecting those azoospermic individuals with real chances of obtaining spermatozoa[...]

06 Apr

NANOMOL group, coordinator of NANBIOSIS Unit 6 collaborates with the VHIR in the developement of a new nanomedicine for the treatment of a childhood cancer

Within the MOTHER project (Molecule-based materials and supramolecular organizations for therapy, diagnosis and tissue engineering), the NANOMOL group from ICMAB collaborates with the Vall d’Hebron Institute of Research (VHIR), on the developement of a new nanomedicine for the treatment of high risk neuroblastoma, one of the most typical childhood cancers. Now, researchers from VHIR have identified new microRNAs that reduce the progression of this type of cancer. The participation of NANOMOL group and NANBIOSIS unit 6 Biomaterial Processing and Nanostructuring Unit, as experts in nanoparticles and nanovesciles for nanomedicine, is on the synthesis of the adequate nanocapsules to protect, stabilize and direct this microRNAs molecules to t[...]