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26 Feb

Fabry disease & Smart4Fabry project

The Fabry disease (FD) is a lysosomal storage disorder (LSD) that currently lacks an effective treatment. Lysosomes are spherical vesicles, which contain hydrolytic enzymes found in nearly all animal cells. LSDs are caused by lysosomal dysfunctions, usually because of the deficiency of a single enzyme required for the metabolism of macromolecules such as lipids, glycoproteins and mucopolysaccharides. Fabry disease is a progressive, X-linked inherited disorder caused by deficiency or absence of the α-galactosidase A (GLA) activity, an enzyme involved in the glycosphingolipid metabolism. The substrates of GLA are glycosphingolipids, being the primary substrate the globotriaosylceramide (Gb3). Therefore, the failure of GLA activity leads[...]

04 Feb

NANBIOSIS Against Cancer

The World Health Organization, the International Cancer Research Center (IARC) and the International Union Against Cancer (UICC) celebrate February 4 of each year as World Cancer Day Every year, 14 million new cases of cancer are diagnosed worldwide and the disease causes 8.2 million deaths. Thanks to scientific research, great advances have been made in the fight against cancer. Through surgery, chemotherapy or radio therapy and, in the last 20 years, through immunotherapy, hormonal treatment or cell therapies, tools have been obtained to improve early diagnosis and treatments, increasing cancer survival by 20%. The only way to understand cancer and,[...]

14 Nov

Drive Pannel Diabetes - Nanbiosis
Diabetes mellitus and pancreatic islet transplant: DRIVE

Today in the World Diabetes Day it is a good moment to remember The Patient Panel of the European project DRIVE- Diabetes Reversing Implants, held in Vitoria (Alava) on June 2 where researches and doctors met with patients and families. The Panel was organized by the NanoBioCel group of CIBER BBN and NANBIOSIS Unit 10 Drug Formulation, with the purpose of letting know the DRIVE project to patients and concect patients with the project scientists and experts in pancreas and stem cell transplantation. Thus, one of the most important health objectives of the European Union was met: to promote direct[...]

19 Jul

Mechanical Characterization of soft biological tissues - Nanbiosis
Mechanical Characterization of soft biological tissues

The experimental study of the mechanical properties of biological tissues is of vital importance. Thorough research into themechanical response of biomaterials is the basis for the creation ofmodels which can accurately reproduce the mechanical behavior ofsuch materials. Adequate mechanical characterization of tissue materials is of paramount interest to the clinical simulations, diagnostic and tissue engineering fields – where the tissue structure, in contrast to classical mechanics application fields, is just simply a biological tissue. In order to obtain their material properties, classical engineering testing techniques have been applied to biologicalmaterials. To reproduce the mechanical behavior of these kinds ofmaterial, many[...]

16 Jan

U12-Nanostructured liquid characterization unit
Characterization of nanomedicines

The quick development of nanotechnology and its application in medicine have generated new alternatives for the diagnosis and treatment of diseases thanks to the novel methods of preparation, modification and characterization of nanomaterials. The knowledge about the behavior of matter at the atomic and molecular level has allowed the creation of tools and processes to observe manipulate and control biological structures on a scale between 100 and 10,000 times smaller than a mammalian cell. Nanomedicine is defined as the application of nanotechnology in view of making a medical diagnosis or treating or preventing diseases. It exploits the improved and often[...]

News about Nanbiosis

25 Mar

“Have we lernt the lesson?”

Heraldo de Aragón publishes today an opinion article written by Jesús Santamaría, Scientific Director of Nanbiosis U9 Synthesis of Nanoparticles Unit about the COVID19 Pandemic in the relation with the investment in R&D. The proffesor at the University of Zaragoza makes a quick review on the the main milestones reached by researchers to fight the COVID 19: “In early December some Wuhan residents start to get sick after visiting a local market, with what looked like flu symptoms. Nevertheless, Chinese health officials report to World Health Organization on New Year’s Eve that a group of patients presented a new ty[...]

24 Mar

NANBIOSIS keeps working in SAFE-N-MEDTECH!

On March 10-12 a two-day meeting between representatives of NANBIOSIS units, took place at the  Jesús Usón Minimum Invasive Surgery Center (CCMIJU), in Cáceres, to plan the work to be done in the coming months and carry out some tests within the framework of the European project Safe-N-MedTech. Several units of the ICTS NANBIOSIS will carry out some of the F/Q, in vivo and in vitro characterizations applied to the test cases of the project. NANBIOSIS is actively involved and works in close collaboration with the four Test Case Developers: Stryker, RCL, HELIA Biomonitoring and TECNAN. Additionally, NANBIOSIS is t[...]

20 Mar

Peptide functionalized nanoliposomes for biomolecule intracellular delivery, prepared using compressed CO2

The PhD Researcher Dolores Bueno researcher of NANOMOL Group and NANBIOSIS Unit 6 Biomaterial Processing and Nanostructuring Unit (from CIBER-BBN and ICMAB-SCIC) has defended her PhD thesis today, 20 March 2020, by videoconference from the ICMAB Meeting Room. No public was allowed due to the drastic measures of containment taken to tackle COVID-19. Peptide functionalized nanoliposomes for biomolecule intracellular delivery, prepared using compressed CO2  Abstract: Fabry disease is a rare disease caused by a gene mutation on the X-chromosome, which encodes α-galactosidase A (GLA) enzyme. The lack of GLA causes the accumulation of globotriaosylceramide at the lysosomes. The actual treatment is[...]

19 Mar


The Spanish Official State Bolletin of March 18, 2020 published the Royal Decree-Law establishing measures to support research on COVID-19, including the authorization of an extraordinary credit for direct grants for research projects and programs of the COVID-19.The Carlos III Heath Institute (ISCIII) calls for the presentation of expressions of interest to promote knowledge about SARS-CoV-2 and the CoVid disease19, as well as its impact on infected people. The aim of the proposals shall be to contribute to an efficient treatment of patient and / or public health rresponse. Proposals must be appropriate to the emergency situation and, therefore, allow[...]

17 Mar

Covid-19 vaccine resear will be founded with 30 million € by the Spanish goverment

Pedro Sánchez, the Spanish President has announced today the decision of the  Council of Ministers to allocate 30 million euro for the research of the SARS-CoV2 coronavirus vaccine. This budget item will go to the Higher Center for Scientific Research (CSIC), State Agency for Scientific Research and Technological Development, and the Carlos III Health Institute (ISCIII), dependent on the Ministry of Science and Innovation. Specifically, 25.2 million euro will go to the ISCIII, of this amount, 24 million will directly finance research projects and programs for the new coronavirus. The ISCIII, as a research funding agency in the health field,[...]

14 Mar

Laura Lechuga talks about CONVAT, the project for a faster and cheaper diagnose of COVID-19

Prof. Laura M. Lechuga, Scientific Director of NANBIOSIS Unit 4 Biodeposition and Biodetection Unit (from CIBER-BBN and ICN2-CSCIC) has been today interview by Cadena Ser Radio in the program “Hoy por Hoy” The interview can be listened in the following podcast, begining at 44 minute. ‘Convat’ is a nanotechnological device with biosensors capable of determining in less than half an hour the presence of coronavirus in a person. A sample saliva is deposited on a nanochip three centimeters long. If the saliva contains the virus, it will bind to antibodies located on the nanochip. A beam of light will be passed[...]

12 Mar

COVID-19 diagnose, faster and cheaper.

In order speed up research into the coronavirus, the European Commission recently announced a special call for projects to tackle the COVID-19, based on already developed technologies. Projectcs were prepared in a record time and 17 proposals have been awarded founds, 6 of them with spanish colaboration and only one coordinated by Spain CONVAT is a cooperation project between Spain, Italy and France coordinated by Prof. Laura M. Lechuga, Scientific Director of NANBIOSIS Unit 4 Biodeposition and Biodetection Unit (from CIBER-BBN and ICN2-CSCIC) and also participated by the group of Prof. Jordi Serra Cobo from the University of Barcelona, having extensive experienc[...]

01 Mar

New COVER in Chemistry. A European Journal: an active organic radical stable agains racemization!

The journal Chemistry. A European Journal features in its COVER the recently published article “An enantiopure propeller‐like trityl‐brominated radical: Bringing together a high racemization barrier and an efficient circularly polarized luminescent magnetic emitter” authored by rearserchers of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit, led by Jaume Veciana (CIBER-BBN, ICMAB-CSIC) Nowadays, it is necessary to know the increasingly specific requirements of electronic devices in order ot be able to find new multifunctional materials that allow obtaining more efficient devices. This article represents a step forward in the field of organic free radicals. Organic free radicals act as polarized light emitters synthesizing and[...]

27 Feb

Rare diseases Day February 29: combating Fabry Disease

29 of February is a ‘rare’ date and February, a month with a ‘rare’ number of days, has become a month to raise awareness about rare diseases and their impact on patients’ lives.  Since 2008 thousands of events happen every year all around the world and around the last day of February. NanoMed Spain Platform and the Hospital of Sant Joan de Déu have organized the NanoRareDiseaseDay to present the latest innovations in the field of Nanomedicine for the treatment and diagnosis of rare diseases (diseases affecting less than 5 people per 10,000 inhabitants). Nora Ventosa, Scientific Director of NANBIOSIS U6 Biomaterial Processing[...]

25 Feb

Course on Coloretal Endoscopy for Surgeons

JUMISC and the Spanish Association of Coloproctocology has organised the ICourse on Coloretal Endoscopy for Surgeons which wil take place at JUMISC on March, 9 -10, co-Directed by  Fernando de la Portilla de Juan (President of Spanish Association of Coloproctology) and Francisco M. Sanchez Margallo (Deputy Scientific Director of NANBIOSIS)   The course includes colonoscopy practices in pig and canine models. For further information and inscriptions: her[...]

24 Feb

#RareDiseaseDay: Fabry lysosomal disease

Rare Disease Day is annually held on the last day of February in more than 100 countries with the main objective of raising awareness about rare diseases and their impact on the life of patients to the general public and in particular to policy makers, public authorities, industry representatives, researchers and professionals. Rare diseases are those that affect less than 1 in 2000 people. There are more than 300 million people living with one or more than more than 6000 rare diseases worldwide identified. Among the events organized we wont to mention the Nano Rare Diseases Day held in Barcelona[...]

23 Feb

Preliminary Market Consultation (CPM): technology development in the field of organ preservation.

The Center for Industrial Technological Development (CDTI) has selected the proposal presented by JUMISC, partner of NANBIOSIS, on the technological challenge of an alternative cold preservation system in a preliminary market consultation.On February 4, the Technical Conference of the Preliminary Market Consultation of the Organ Preservation Challenge was held.The objective of the Preliminary Market Consultation was to obtain information from the market operators in the Organ Preservation technologies in order to adequately define the future potential for pre-commercial Public procurement and adequately inform the economic operators of the requirements that will be required in the Potential future tender for pre-commercia[...]

17 Feb

Organ-on-chip monitoring. Breakthrough technological approximations

Organ-on-chip (OOC) is the term used to define a microfluidic 3D culture model that contains continuously perfused chambers inhabited by living cells. OOC are considered as very promising tools for investigating many aspects of human physiology and pathophysiology as well as drug testing platforms with future progressions to be used for precision medicine. As the complexity of OOC systems increases, the necessity to integrate relevant assessment methods to provide information about cell physiology, secreted metabolites as well as pharmacodynamics drug responses also increases. Dr. Rosa Villa, who leads NANBIOSIS U8 Nano Technology Unit and the Biomedical Applications Group of t[...]

14 Feb

Challenges in precision medicine

Transfiere, the European Forum for Science, Technology and Innovation,  the bigest professional and multisectoral forum for the transfer of knowledge and technology held in Spain, took place last February 12 and 13 in Malaga in its 9th edition. Among the events held at Transfiere, there has been a round table organized by all health-related platforms under the title: Challenges in precision medicine on the 12th at 6pm. Maria Luisa García Martín, Scientific Director of NANBIOSIS U28 of Nanoimaging Unit and head of Nano-Imagen  facilities at BIONAND, was invited by the Nanomedicine platform, NanomedSpain as a speaker at the aforementioned round[...]

13 Feb

Mechanism and Consequences of the Impaired Hif-1α Response to Hypoxia in Human Proximal Tubular HK-2 Cells Exposed to High Glucose

NANBIOSIS has been informed about a recent publication in the pretigious scientific magzine SCIENTIFIC REPORTS (Q1) of Nature Research group, mentioning NANBIOSIS Unit 17 in the Methods section: Immunofluorescence analysis: Detection was performed by using a Leica SP5 confocal microscope (Leica Microsystems, Wetzlar, Germany), through the Confocal Microscopy Service of the ICTS ‘NANBIOSIS’ Unit 17 of the Biomedical Research Networking Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) at the University of Alcalá, Madrid, Spain. HIF-1α-dependent immunofluorescence intensity was quantified after digital capture using image-J software. The Leica TCS-SP5 confocal microscope with especial features allows studying interactions between cells/tissues and materials.[...]

12 Feb

VII Course of Microscopic and Piezoelectric Techniques in Dentistry: Endodontics, Implantology and Prosthetics

CCMIJU has organised the VII Course of Microscopic and Piezoelectric Techniques in Dentistry: Endodontics, Implantology and Prosthetics, which wil take place at JUMISC from March 3 till June 27 2020 under the Direction of Alberto Anta Escudero. (Profesor of the UPV-EHU), Gorka Santamaría Arrieta (Professor of the UPV-EHU), Jon Eskurza Pérez (Endodontics Specialist. Private Clinic) and Francisco Miguel Sánchez Margallo (Deputy Scientific Director of NANBIOSIS) The general objective of the course is the knowledge of the enodontology magnification, necessary materials and instruments and related ergonomic aspects. Training in magnification in dentistry Frurther information: Programm and inscriptions[...]

11 Feb


In order to achieve full and equitable access and participation in science for women and girls, and also to achieve gender equality and the empowerment of women and girls, the United Nations General Assembly decided to proclaim in 2016 (resolution A / RES / 70/212) February 11 as the International Day of Women and Girls in Science. We want to take this day to congratulate all the women who lead research and innovation and contribute to the breakdown of the barriers that still exist, especially to the scientists from NANBIOSIS ICTS. Happy International Day of Women and Girls in Science![...]

10 Feb

A new smart drug that finds and kills metastasis cells could be applied in 23 types of cancer

Researchers of two CIBER-BBN Units of the ICTS NANBIOSIS  U18 Nanotoxicology Unit at Hospital Sant Pau. and U1, Protein Production Platform (PPP), at the  Institute of Biotechnology and biomedicine of the Autonomous University of Barcelona (IBB–UAB), led by Prof Ramón Mangues, have developed a new drug that selectively removes metastatic stem cells, inducing a powerful metastasis prevention effect. Besides the participation of the “NANBIOSIS” ICTS Units U1 Protein Production Platform where Protein production was partially performed and U18 Nantoxicology Unit where Biodistribution studies were performed, all in vivo experiments were performed by the Unit 20 In Vivo Experimental Platform of CIBER[...]

07 Feb

Ethylcellulose nanoparticles as new “in vitro” tool for cell transfection

Researchers of NANBIOSIS U12 Nanostructured liquid characterization unit and U29 Sintesis of acid nucleic of CIBER-BBN at IQAC-CSIC have obtained successfully ethylcellulose nanoparticles with positive zeta potential formed from nano-emulsion complexation with an antisense oligonucleotide which result very promising complexes for “in vitro” cell transfection. A new non-viral gene delivery vector has been developed, based on ethylcellulose, an easily available and low cost carbohydrate polymer, “generally recognized as safe” by the FDA. Although ethylcellulose is nonionic, positively charged nanoparticle dispersions have been obtained using nano-emulsion templates in cationic:non-ionic surfactant-based systems. The nanoparticles have been successfully complexed with negatively charged phosphorothioate antisense oligonucleotides. These short nucleic[...]

04 Feb

NANBIOSIS research to fight cancer

Twenty years ago, the 4 February was declared World Cancer Day with the global challenge of cancer would not be forgotten. Since then, huge progress has been made to understand, prevent, diagnose, and treat cancer. NANBIOSIS as an ICTS (Singular Scientific and Technical infrastructures) for biomedical research plays a very important role in the fight against cancer. Some examples of the work carried out during the last year, are bellow: Unit 20 of NANBIOSIS  at VHIR, works in several proyects reletaed to cancer as  H2020-NoCanTher: magnetic nanoparticles against pancreatic cancer through the use of hyperthermia combined with conventional treatment. H2020-Target-4-Cancer: nanotherapy based on polymeric micelles directed against[...]

30 Jan

EUROAGE: to improve people’s quality of life and increase healthy life expectancy

The Center for Minimally Invasive Surgery (JUMISC), partner of NANBIOSIS, as the main beneficiary of the Spain-Portugal EUROAGE cross-border cooperation project that promotes active aging in the region, has presented its results and its impact on society, within the Spanish-speaking meeting ‘ Forum of Iberian Stories. 30 years of the INTERREG Spain-Portugal Cross-Border Cooperation Program (POCTEP) ’. Specifically, the event has been organized by the agencies EFE and LUSA, and took place this past Wednesday at the headquarters of the Spanish agency in Madrid, with the support of the Directorate General for Regional Policy (DGRegio) of the European Commission. Its[...]

28 Jan

New book by NANBIOSIS U14: Basic research procedures in the cell therapy laboratory

Researchers of NANIOSIS Unit 14 at JUMISC have published a new book titled Basic research procedures in the cell therapy laboratory, in which some basic techniques and general principles for adult stem cell research are explained. Stem cells are cells capable of differentiating into a wide variety of cell types and can be isolated from different tissues such as. They have regenerative and anti-inflammatory properties thanks to the secretion of paracrine factors. Currently, these cells are being widely used in clinical trials for the treatment of different diseases such as Crohn disease, multiple sclerosis, diabetes, rheumatoid arthritis or myocardial infarction.[...]

28 Jan


Jose Luis Pedraz, Jesus Ciriza and Angela Losada of NANBIOSIS U10 Drug Formulation – NanoBioCel Group of CIBER-BBN and University of the Basque Country were in Leuven, Belgium attending the European Project POSITION-II Workshop #5, which was held between January 21 and 23. The workshop was held at the facilities of iMEC, one of the partners of the project and world leader in R&D in nanoelectronics and digital technology. The project lasts three years and after 18 months, in this workshop, the researchares of NANBIOSIS U10 Drug Formulation, have microencasulated and characterized the heart cells with the aim of checking[...]

27 Jan

Researchers from NANBIOSIS Unit 8 opt for the Cutting-Edge Science Award: How to measure brain’s hidden activity.

La Vanguardia and the Fundació Catalunya La Pedrera have jointly promoted for the tenth consecutive year the Cutting-Edge Science Award “La Vanguardia de la Ciencia”, with the objective of givin visibility to the research of excellence carried out in Spain. The prize will correspond to the proposal candidate most voted by the public. One of the 8 selected candidates is the research led by Anton Guimerà-Brunet (NANBIOSIS Unit 8 -Institut de Microelectrònica de Barcelona-CNM-CSIC / CIBER-BBN) and Jose Garrido (Institut Català de Nanociències i Nanotecnologia / Icrea), for developing graphene implants capable of measuring the hidden activity of the brain[...]

26 Jan

Support for companies: Nanotechnological Bonds

From the NFP research group of CIBER-BBN and INA, led by Jesus Santamaria, that coordinates NANBIOSIS U9 Synthesis of Nanoparticles Unit, and through the SAMCA Nanotechnology Chair, the call for grants has been launched: Nanotechnological Bonds For more information: http://capsulasdenanotecnologia.es/bonos-nanotec/[...]

24 Jan

PICCOLO Project 7th Face-to-Face Meeting at JUMISC (NANBIOSIS)

The Piccolo consortium members met at JUMISC (Cácere) last on 21st-22nd January to hold the 7th face-to-face meeting. Project partners had the chance to visit Nanbiosis U21 Experimental operating rooms led by Francisco M. Sánchez Margallo and participate in a training session with the prototype demo. A murine specimen was analysed ex-vivo with the probe and the clinicians had the opportunity to evaluate the features present in a neoplastic polyp. The meeting agenda included a general overview of the project, the status update of OCT (Optical Coherence Tomography), MPT (Multiphoton Tomography) and fluorescence technologies, deep learning algorithms preliminary results, t[...]

23 Jan


JUMISC has organised the II Course for the performance of functions A, B and C in rodents, lagomorphes, carnivores, pigs and small rumiants  which wil take place at JUMISC from 3 February to 20 March co-Directed by D. LUIS DÁVILA GÓMEZ, Scientific Director of NANBIOSIS U22. Animal housing and  DR. FRANCISCO MIGUEL SÁNCHEZ MARGALLO (Deputy Scientific Director of NANBIOSIS) The total duration of the course is 100 hours (58 theory and 42 practice) This course has as specific objectives to provide information and expand existing knowledge in the following aspects: -Specific legislation regarding animal experimentation . -Ethical considerations and the principles of replacement, reduction and refinement. -Biology, housing, handling and care of experimental animals. -Occupational health and safety. -Recognition of the stat[...]

20 Jan

A new fluorescent probe for NO

Nitric oxide is a component of the pollutant nitrogen oxides (NOx) responsible of different environmental negative effects. However, due to its physiological effects, NO has been used in different therapeutic applications. Thus, the inhaled nitric oxide (iNO) is a selective pulmonary vasodilator that finds its best applications in pediatrics, by transiently improving oxygenation in respiratory failure and persistent pulmonary hypertension. The initial recommended concentration of iNO in these treatments is 20 ppm. Higher concentrations do not increase its effectiveness and are associated with a higher incidence of methemoglobinemia and formation of nitrogen dioxide. In consequence the control of iNO concentration is[...]

17 Jan

Tumor Immunology and Cancer Immunotherapy Course

The IV course on Tumor Immunology and Cancer Immunotherapy will start on 6th Feb, 2020. On April 2 at 7:00 pm Iñaki Ochoa will teach about “Basic research in cancer immunotherapy. Use of microfluidics in the study of cancer immunotherapy“. Ignacio Ochoa is a Professor of the Department of Human Anatomy and Histology of the University of Zaragoza and researcher of the AMB – Applied Mechanics and Bioengineering group and NANBIOSIS U13 Tissue & Scaffold Characterization Unit from CIBER-BBN and I3A-Zaragoza University Classes will be held on Thursday, from 4:00 p.m. to 8:00 p.m., in the CIBA Lorente de Nó[...]

16 Jan

New nanocarrier for bio-imaging and drug-delivery applications

Researchers of CIBER-BBN and NANBIOSIS-ICTS (U6 Biomaterial Processing and Nanostructuring Unit at ICMAB-CSIC and U18 Nanotoxicology Unit at  Hospital de la Santa Creu i Sant Pau have developed a new nanocarrier for bio-imaging and drug-delivery applications The new nanovesicle formulation is based on the quatsome architecture – which stands out due to the high colloidal stability and homogeneity in size – and has now been shown to be suitable for in vivo dosing. Quatsomes are new non-liposomal lipid-based nanovesicles that have been developed by Nanomol group in recent years, and have been shown to be highly homogeneous and stable in[...]

15 Jan


CCMIJU has organised the II Urological Laparoscopy Course: Suture Management and Intracorporeal Knotting which wil take place at JUMISC from 3 to 5 February under the Direction of Álvaro Serrano Pascual (Urology Service Specialist at the San Carlos Clinical Hospital, Madrid) and Francisco Miguel Sánchez Margallo (Deputy Scientific Director of NANBIOSIS) It is a basic course of Laparoscopic Urology where the techniques of Laparoscopic Radical and Partial Nephrectomy will be carried out. The objective of this course is for specialists in Urology to improve their skills in suture management and intracorporeal knotting. Programm and inscriptions her[...]

11 Jan

A step forward in the field of organic free radicals acting as chiral emitters

Researchers of NANBIOSIS U6. Biomaterial Processing and Nanostructuring Unit have just published the article titled “An enantiopure propeller ‐ like trityl ‐ brominated radical: Bringing together a high racemization barrier and an efficient circularly polarized luminescent magnetic emitter” in the scientific magazine Chemistry A European Journal. The urgent need to cope with the more and more specific requirements in electronic devices is nowadays behind the search for new multifunctional materials. In this work, a step forward has been done in the field of organic free radicals acting as chiral emitters. The recently developed brominated trityl derivative, namely TTBrM radical, shows[...]

30 Dec

A step forward for the design of multifunctional protein nanomaterials for cancer therapies

Researchers of NANBIOSIS Unit 1 and NANBIOSIS Unit 18, led by Prof Antoni Villaverde have published the article at the prestigious scintific magazine titled Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer The researchers have shown that the combination of cell-penetrating and tumor cell-targeting peptides dramatically enhances precise tumor accumulation of protein-only nanoparticles intended for selective drug delivery, in mouse models of human colorectal cancer. This fact is a step forward for the rational design of multifunctional protein nanomaterials for improved cancer therapies. Protein production has been partially performed by the  ICTS NANBIOSIS U1, Protein Production Platform[...]

28 Dec

Pilar Marco honored by the Spanish National Research Council (CSIC)

Maria Pilar Marco Colás has been honored by the Spanish National Research Council (CSIC) in appreciation for having complited 25 years of work at the CSIC, an intense period of 25 years at the service of Science, 11 of them as Scientific Director of Custom Antibody Service (CAbS), unit 2 of NANBIOSIS since its inclusion in the national ICTS map.[...]

27 Dec

Why the poor biodistribution so far reached by tumor-targeted medicines?

Cell-selective targeting is expected to enhance effectiveness and minimize side effects of cytotoxic agents. Functionalization of drugs or drug nanoconjugates with specific cell ligands allows receptor-mediated selective cell delivery. However, it is unclear whether the incorporation of an efficient ligand into a drug vehicle is sufficient to ensure proper biodistribution upon systemic administration, and also at which extent biophysical properties of the vehicle may contribute to the accumulation in target tissues during active targeting. To approach this issue, structural robustness of self-assembling, protein-only nanoparticles targeted to the tumoral marker CXCR4 is compromised by reducing the number of histidine residues (from[...]

23 Dec

Artificial inclusion bodies for controlled drug release

Researchers from NANBIOSIS-CIBER-BBN have developed a new type of protein biomaterial that allows a continuous release over time of therapeutic proteins when administered subcutaneously in laboratory animals. These results are the result of the stable scientific collaboration between the researchers of NANBIOSIS Units 1 Protein Production Platform (PPP)and 18 Nanotoxicology Unit, led by Toni Villaverde and Ramón Mangues at the Institute of Biotechnology and Biomedicine of the Autonomous University of Barcelona (IBB-UAB) and the Institut About the Hospital de Sant Pau and has had the participation of the Institute of Biological and Technological Research of the National University of Córdoba-CONICET,[...]

17 Dec

A new method simple and efficient for the preparation of Oligonucleotide-protein conjugates

Oligonucleotide-protein conjugates have important applications in biomedicine. Four units of NANBIOSIS have collaborated to come across with more simple and efficient methods for the preparation of these conjugates. In the publication of the research results, a new method is described in which a bifunctional linker is attached to thiol-oligonucleotide to generate a reactive intermediate that is used to link to the protein. Having similar conjugation efficacy compared with the classical method in which the bifunctional linker is attached first to the protein, this new approach produces significantly more active conjugates with higher batch to batch reproducibility. In a second approach,[...]

16 Dec

A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models

Researchers of NANBIOSIS Unit 1 and NANBIOSIS Unit 18,  led by Ramón Mangues, have published the article titled CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models . One-third of diffuse large B-cell lymphoma patients are refractory to initial treatment or relapse after rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy. In these patients, CXCR4 overexpression (CXCR4+) associates with lower overall and disease-free survival. Nanomedicine pursues active targeting to selectively deliver antitumor agents to cancer cells, a novel approach that promises to revolutionize therapy by dramatically increasing drug concentration in target tumor cells. In the study carried out[...]

13 Dec

Inkjet printing and paper sensors to control different analytes with low cost technologies

‘I investigate, I am CSIC’ is a competition hold by The Spanish National Research Council (CSIC) for its doctoral students to disseminate their doctoral thesis. Through short videos of maximum duration of 3 minutes, predoctoral scientists explain their research and results in an informative language. Miguel Zea, a member of the NANBIOSIS U8 Micro– Nano Technology Unit presents his video explaining how paper sensors can be manufactured to control different analytes with low cost technologies such as Inkjet Printing. A jury composed of five experts in communication or scientific dissemination will choose eight videos taking into account the originality, impact,[...]

04 Dec

“Tips and tricks to achieve good results at the bench”

The IBEC Core Facilities team, coordinating NANBIOSIS U7 Nanotechnology Unit has celebrated the 6th edition of the Workshop “Tips and tricks to achieve good results at the bench”. This workshop is focused on fundamental basic aspects of working in a Chemistry/Biology laboratory: process of performing an experiment, from previous planning until the moment of leaving the bench. The workshop was divided in two parts: Introduction and overview to the Good Laboratory  Practices.Highly interactive and practical daily lab situations with real equipment. Upon completion of this workshop participants are able to understand the basics of good laboratory practices, plan an experiment[...]

02 Dec

Carlos Rodriguez-Abreu (NANBIOSIS U12) keynote speaker in OKINAWA COLLOIDS 2019

Carlos Rodriguez-Abreu, Scientific Director of NANBIOSIS U12 Nanostructured liquid characterization unit has been invited speaker at OKINAWA COLLOIDS 2019 conference in Okinawa, Japan on November 3 to 8, 2019 in the session Foams / Bubbles / Emulsions and Microemulsions.Foams and emulsions stabilized by surfactants, amphiphilic polymers and solid particles are essential formulations for developing pharmaceuticals, cosmetics, foods and so on. Recently, many functional systems have been proposed including stimuli responsive materials, biocompatible materials, and environmental affinity materials. The topics of this session include a wide range of subjects: physical properties, phase behaviors and new functions of these systems.[...]

27 Nov

NANBIOSIS internal dissemination day

NANBIOSIS has celebrated today the second edition of NANBIOSIS internal dissemination day, at the ICMAB-CSIC, Barcelona. The Day has been focuss on the staff that deals with the day-to-day work of the units, especially technical staff. The event was attended by technicians and coordinators of the units of Catalonia and Aragon (almost 30 face-to-face assistants) and has been followed through the streaming broadcast by the other units. The day has been presented by the NANBIOSIS Scientific Director Jaume Veciana and the Nerea Argárate Coordinator, followed by a round of presentations by the attendees and their work in the different NANBIOSIS[...]

26 Nov


We are pleased to inform that the new book of Unique Scientific and Technical Infrastructures (ICTS) has been published by the Spanish Ministery of Innovation, Science and Universities with the collaborations of the ICTS. The Spanish Map of Unique Scientific and Technical Infrastructures (ICTS), goups biomedical technologies, cleanrooms, supercomputers, advanced lasers, telescopes, underground laboratories, synchrotrons, particle accelerators, biological reserves, solar, oceanic and hydraulic platforms, oceanographic research ships, and polar bases in Antarctica. A total of 29 ICTS, made up of 62 nodes, allow for ambitious research projects that attract first-rate talent and enhance the technological and innovative industry capacities. “Through a[...]

25 Nov

Agreement signed with MINECO for the allocation of FEDER funds for NANBIOSIS ICTS

In the framework of the FEDER Program in ICTS 2014-2020, a project related to the ICTS NANBIOSIS has been selected by the Ministry of Science, Innovation and Universities for co-financing with FEDER funds of the European Regional Development Funds program. An agreement has been signed between the Ministry of Science, Innovation and Universities and the Institute of Bioingeniería of Catalonia (IBEC) for the implementation of the project “Mask Aligner Team for the unit of Nanotechnology (U7) of Nanbiosis” cofinanced by FEDER Performance Program 2014-2020.  The total budget of the project amounts to € 117.000, with 50% financing with FEDER Funds. IBEC isprocessing t[...]

22 Nov

I ONLINE Course on Introduction to Quality Management in Laboratories in the Biosanitary Field

The Jesús Usón Minimally Invasive Surgery Center (JUMISC), organizes the 1st ONLINE Course on Introduction to Quality Management in Laboratories in the Biosanitary Field. The course will count with the expertise Beatriz Moreno Lobato, Scientific Director of NANBIOSIS Unit 19 CLINICAL TEST LAB, among others. The Course is directed to middle-level technicians: Auxiliary Care of Nursing and Pharmacy and Parapharmacy and also to higher degree technicians: Pathological and Cytodiagnostic Anatomy, Oral Hygiene, Image for Diagnosis and Nuclear Medicine, Clinical and Biomedical Laboratory, Dental Prosthetics, Dietary The course has a capacity for forty attendees and registration is now open here: T[...]

12 Nov

Understanding between doctors and engineers: essential to advance in health

Pablo Laguna Lasaosa, New Director of I3A and scientific director of NANBIOSIS U27 High Performance Computing talks about Biomedical Engineering in the radio programm “La Brujula de Aragón” @OndaCero_ Professor of signal and communications, expert of biomedical signals in the cardio vascular domain, Pablo Laguna talks about engineering today and how the relative weight of engineering is nowadays repesented by the information engineering, computer engineering and the treatment of information to be applyed in different domains, new materials and new ways of addressing and solving problems. For the recently appointed director of the I3A, there is an opportunity in this[...]

11 Nov

Pablo Laguna, new director of the Aragon Engineering Research Institute

Pablo Laguna Lasaosa, Scientific Director of Unit 27 High Performance Computing has been elected new director of the Aragon Engineering Research Institute (I3A). Pablo Laguna Lasaosa, Professor of Signal Theory and Communications at the School of Engineering and Architecture (EINA) of the University of Zaragoza, develops its research activity in the field of signal processing, particularly applied to biomedical applications. Laguna is co-author of more than 150 research articles on this subject, more than 10 book chapters, more than 300 international conference documents and director of 15 doctoral theses. He has led a good number of projects on the interpretation[...]

10 Nov

III Conference on the Disclosure of Biomedical and Experimental Sciences

The III Conference for the Disclosure of Biomedical and Experimental Sciences will take place at the Center for Minimally Invasive Surgery Jesús Usón of Cáceres, on December 5, 2019. It will be attended by Francisco Miguel Sanchez Margallo, Deputy Scientific Director of NANBIOSIS and Beatriz Moreno Lobato, Scientific Director of Unit 19 of NANBIOSIS FREE ACTIVITY – Requires prior registration until full capacity is reached Pre- registration: https://www.ccmijesususon.com/formacion/preinscripcion/1173/ Program: Detalle de Curso[...]

09 Nov

Jesús Santamaría new Corresponding Academician of the Royal Canary Academy of Sciences

Jesús Marcos Santamaría Ramiro, Scientific Director of NANBIOSIS Unit 9 Synthesis of Nanoparticles Professor of Chemical Engineering at the University of Zaragoza and Deputy Director of the University Institute of Nanoscience of Aragon has been appointed new Corresponding Academician of the Royal Canary Academy of Sciences. Reception of the new Corresponding Academician took place last November 7th at the Hall of the Canary Islands Advisory Council in La Laguna the entry speech of the new Corresponding Academician was tittled “Heterogeneous Catalysis 4.0: Opportunities for catalysts when they leave the reactor”[...]

08 Nov

Non-Hodgkin lymphoma treatment with protein nanoparticles

A study result of collaboration between researchers of two NANBIOSIS units managed to produce a potent antitumor effect in an animal model with non-Hodgkin lymphoma A non-Hodgkin’s lymphoma, NHL is a cancer that starts in white blood cells called lymphocytes, which are part of the body’s immune system. Lymphoma. NHL is a term that’s used for many different types of lymphoma that share some characteristics.  The most prevalent type of non-Hodgkin lymphoma is called diffuse large B-cell lymphoma (LDCGB). Although there are treatments for this pathology, there are non-responders. This nanoparticle can be developed as a nanopharmaceutical, in order to introduce a new treatment, whic[...]

07 Nov

NANBIOSIS expertise on Nanoparticles Characterization by Amable Bernabé.

Amable Bernabé, Technical Coordinator of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit has given a course from Monday, 7 October, to Wednesday, 9 October on “Characterization techniques for particulate materials”. The course has counted with 12 participants from different CSIC centers (including ICMAB, IBM-CNM, ICM, IQAC…) and has introduced the participants to different techniques to characterize nanoparticles and other particulate matter, including the basic fundamentals, sample preparation, practical examples and results interpretation.  It is the second time that Amable Bernabé, technician from the Sof tLab, has decided to offer this course to all the CSIC community, so they can learn new methods to characterize nanoparticles,[...]

06 Nov

A Minimally Invasive Microsensor Specially Designed for Simultaneous Dissolved Oxygen and pH Biofilm Profiling

Ana Moya, Xavi Illa, Rosa Villa and Gemma Gabriel, researchers of the Biomedical Application’s Group (GAB) of CIBER-BBN and the Microelectronics Institute of Barcelona, which main interests are the design and fabrication of Micro and Nano Systems for Biomedical Applications, have recently published, in collaboration with other authors an article in the Special Issue Advanced Electrochemical Sensors and Environmental Monitoring The authors thank in the Acknowledgements the participation of the ICTS NANBIOSIS U8 Micro– Nano Technology Unit of the CIBER in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) at the IMB -CNM (CSIC) The work reports the development of a novel multi-analyte microsensor[...]

06 Nov

NANBIOSIS Scientific Director, Jaume Veciana, coauthor of an article highlighted in Chemistry Views

Jaume Veciana, Scientific Director of NANBIOSIS is coauthor of an article chosen to be highlighted on the ChemistryViews newsletter: “Organic Free Radicals as Circularly Polarized Luminescence Emitters”, published in Angewandte Chemie International Edition, and is about the intrinsic chiral emission of enantiometric organic free radicals. The short news about the paper is entitled “Circulary Polarized Light from Organic Radicals” is available here.  Circularly polarized luminescence (CPL) can occur when a luminescent compound has a chiral structure. Organometallic structures are leading in CPL activity. However, purely organic CPL emitters are promising alternatives in several applications where low toxicity is important (i.e., bioimaging). Jaume Veciana (Institut de Ciéncia de Materials de Barcelona (ICMAB), Spain), Araceli G. Campaña (University of Granada, Spain)[...]

05 Nov

Unit 16 of NANBIOSIS will expand its capabilities with cofinancing of FEDER funds

On October 25, the Monitoring Commission of the agreement signed on July 15 was established by the Ministry of Economy, Industry and Competitiveness and the University of Extremadura for the acquisition of new equipment that will expand the capabilities of Unit 16 of NANBIOSIS. One of the 26 Units that constitute NANBIOSIS is Unit 16 “Unit of Surface Characterization and Calorimetry” of CIBER-BBN and the University of Extremadura. The application of this FEDER cofinancing will allow the expansion of the capabilities of this unit for the chemical, physicochemical, and topographic characterization of surfaces, improving the competences in mass spectrometry by[...]

03 Nov

New inside backcober by researchers of NANBIOSIS U9

Researchers of NANBIOSIS U9 Synthesis of Nanoparticles Unit Ignacio Julian, José L. Hueso, Reyes Mallada and Jesús Santamaría, are co-authors of an article with inside backcover recently published by the scientific magazine Catalysis, Science and Tecnology. The synthesis of the materials has been performed at the Platform of Production of Biomaterials and Nanoparticles of the NANBIOSIS ICTS, more specifically at the Nanoparticle Synthesis Unit 9 of the CIBER in BioEngineering, Biomaterials & Nanomedicine (CIBER-BBN) Article: Polyoxometalates as alternative Mo precursors for methane dehydroaromatization on Mo/ZSM-5 and Mo/MCM-22 catalysts. Julián I, Hueso J.L, Lara N, Solé-Daurá A, Poblet J,M, Mitchell S.G, MalladaR, Santamaría J.Catal. Sci.[...]

02 Nov


During de dates Nov. 18 -30, 2019 will take place de course on line on Introduction to Research and Laboratory Techniques in Biociences, under the direction of NANBIOSIS U14 Cell Therapy Unit led by Javier García Casado Scientific Director of the Unit and Francisco M. Sánchez Margallo Scientific Director of CCMIJU and Deputy Scientific Director of NANBIOSIS. For further information: Online Course on INTRODUCTION TO RESEARCH AND LABORATORY TECHNIQUES IN BIOCIENCES Matriculación onlin[...]

01 Nov


The Nanobiotechnology for Diagnostics group (Nb4D) of CIBER-BBN and IQAC-CSIC, (coordinator of NANBIOSIS U2 Custom Antibody Service (CAbS)), led by Prof. Mª Pilar Marco, is organizing a workshop on “Ethical aspects of research” netx 18th November 2019, at the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC).  There will be three sessions given by experts from this topic area. TECHNOLOGICAL ADVANCES VERSUS ETHICS by Dr. José Ignacio Latorre ANIMAL TESTING by Dr. Lluís Montoliu CLINICAL SAMPLES, BIOBANKS AND OTHER ASPECTS IN CLINICAL PRACTICE by Dr. Pieter Moons A Certificate of Attendance will be issued for each participant. This workshop is FREE but has LIMITED SPACE. To  register, fill in the form by 10th November[...]

31 Oct

NANBIOSIS U1 PPP will take a critical role in one of the projects selected by La Marató TV3 to fight against cancer

“Selectively humanized nanomedicines aimed at killing CXCR4 + tumor cells for the treatment of acute myeloid leukemia”  is one of the Project awarded by La Marató TV3 Foundation and is participated by Dr. Antonio Villaverde, Estrategic of NANBIOSIS U1 Protein Production Platform (PPP) The main objective of the project is the design and validation of humanized protein nanoparticles for the targeted delivery of antitumoral drugs for the treatment of acute myeloid leukemia. This will be done by the generation of protein-based nanoconjugates that will be targeted to the cytokine receptor CXCR4, overexpressed in this human neoplasia. The drugs will consist[...]

30 Oct

Killing cancer from starvation or by toxicity with Trojan horses.

Jesús Santamaría, who leads the NFP research group of CIBER-BBN and the Institute of Nanoscience of Aragon (INA), at the University of Zaragoza, in an interview on October 29 to Aragon TV, talks about the problems in the fight against cancer and explains in a very didactic way, the solutions that are being approached from his research group, in collaboration with other groups. It would consists, basically, in reducing the tumor from inside the tumor cells. Prof. Santamaria has been granted funding twice from the European Research Council (ERC) Advanced Grant program for catalysis-related projects, the last one with two[...]

29 Oct

“Minimal invasion, maximum innovation”

“Minimal invasion, maximum innovation” is a repot by Spanish TV about the Minimal Invasion Surgery Center, Jesús Usón, partner of NANBIOSIS. “The unique capabilities of the Center from its animal farm to its surgical infrastructure allow the evaluation and validation of new technology such as medical devices, new biomaterials, new pharmacological therapies, before being used in human patients” explains Francisco Miguel Sanchez Margallo, Sciencitific Director of the Center and Deputy Scientific Director of NANBIOSIS- ICTS. Verónica Crisóstomo, Scientific Director of NANBIOSIS Unit 24 of Medical imaging explains a current project that studies how to reduce the damage caused by a[...]

28 Oct

Best Poster award at the congress of Spanish Society of Nephrology

Researchers of Unit 17 of NANBIOSIS Confocal Microscopy Service and the GITBIT-UAH group (CIBER-BBN, Univerty of Alcalá de Henares), have been awarded with the PRIZE FOR THE BEST POSTER COMMUNICATION by the Spanish Society of Nephrology (S.E.N.) and Senefro Foundation. “The ILK deletion prevents extravasation of monocytic line leukocytes induced by the accumulation of uremic toxins during chronic kidney disease” authored by CAMPILLO DE BLAS, L BOHORQUEZ MAGRO, D GARCÍA AYUSO, B GARCÍA CARRASCO, M GRIERA, S DE FRUTOS, M RODRÍGUEZ-PUYOL, D RODRÍGUEZ-PUYOL, L CALLEROS BASILIO.[...]

26 Oct

Formulation of emulsions: Science behind cosmetics at COSMETORIUM

Carlos Rodríguez-Abreu, Scientific Director of NANBIOSIS Unit 12 Nanostructured liquid characterization unit, from Institute of Advanced Chemistry of Catalonia, Higher Council for Scientific Research (IQAC-CSIC) and CIBER of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) has participated in the fourth edition of COSMETORIUM, given a talk on “Recent advances in the formulation of emulsions” The fair of Cosmetorium, which was held at the Palau de Congresos de Barcelona on October 23 and 24, is organized by the Spanish Society of Cosmetic Chemists (SEQC), begun with keynote conferences and a scientific program, which examined the key problems facing the cosmetic and personal care industry,[...]

23 Oct


On October 21 and 22, CIBER-BBN has celebrated its 13th Annual Conference  in Tarragona, with a session dedicated to NANBIOSIS on the afternoon of Monday 21. The Singular Technical Scientific Infrastructure (ICTS) for the production and characterization of biomaterials, nanomaterials and devices up to its preclinical validation for the production and characterization of biomaterials, nanomaterials and devices up to its preclinical validation is integrated by of the CIBER-BBN, the Minimally Invasive Surgery Center Jesus Usón and Bionand after its incorporation to the ICTS last year. NANBIOSIS, presented its annual activity. The Session was chaired by its Scientific Director, Jaume Veciana who also gav[...]

16 Oct

Biomarkers in semen to diagnose prostate cancer

Sara Larriba of the Human Molecular Genetics Group of Bellvitge Biomedical Research Institute (IDIBELL) has informed NANBIOSIS about a recent publication mentioning NANBIOSIS in the Acknowledgements for its participation in the results of their research. (The nanoparticle tracking analysis was performed by the ICTS NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit) The article has been published by the journal Scientific Reports of Nature Research. The prediction of PCa in the early stage of the disease is one of the most important objectives in male urology. A significant decrease in deaths due to PCa has been associated with the use of serum[...]

15 Oct

Nanbiosis and CIBER-BBN present at BioNanoNet and Austrian Microfluidics Initiative (AMI)

Nanbiosis-ICTS and CIBER-BBN were present at BioNanoNet Annual Forum & Networking event and the Austrian Microfluidics Initiative (AMI) workshop “Biomedicine on Chip” that took place on 10-11th of September 2019 at the premises of the University of Salzburg attracting about 40 participants from both science and industry. For furher information: https://www.bionanonet.at/;   www.microfluidicsaustria.at[...]

10 Oct

Preclinical brain tumour therapy response assessment with MRSI approaches: Oral presentation awarded to Ana Paula Candiota

NANBIOSIS U25 scientific coordinator, Ana Paula Candiota, has recently presented a scientific work about preclinical brain tumour therapy response assessment with MRSI approaches in the 36th annual meeting of ESMRMB held in Rotterdam, Netherlands, October 3-5. Work was entitled  “Oscillatory pattern of response in MRSI-based Glioblastoma therapy follow-up: an immune system biomarker?” and was awarded an oral presentation in the scientific session of Animal Models: Brain & others Article of refrence: L. Villamañan, P. Calero, S. Wu, N. Arias-Ramos, M. Pumarola, S. Ortega-Martorell, M. Julià-Sapé, C. Arús, A.P. Candiota. Oscillatory pattern of response in MRSI-based Glioblastoma therapy follow-up: an immune system[...]

01 Oct

Biomedicine Project Manager job vacancy

CIBER-BBN is looking for proyect manager for a european project in biomedicine to coordinate NANBIOSIS units participation in the project. The position requires good command of English and strong skills in coordinating researchers. Applications must be filed at CIBER’s web portal untill October 15.[...]

21 Sep

CIBER-BBN Annual Conference 2019

In one month CIBER-BBN will celebrate its 13th Annual Conference on October 20 and 21 in Tarragona, at the Hotel Ciutat de Tarragona, Tarragona. This year there several scientific sessions are planned about related leading issues with research topics of interest to CIBER-BBN. On Monday there will be three sessions centered in: artificial intelligence and big data gene editing and CRISPR and liquid biopsy and point-ofcare. Each of these sessions will include a plenary conference given by an expertguest and two talks by BBN researchers, followed by an open debate. The program will complete a session focused on the Singular Technical Scientific Infrastructur[...]

15 Sep

NANBIOSIS Unit 10 expands its equipments and capabilities

NANBIOSIS U10 Drug Formulation unit, led by Dr. José Luis Pedraz, has recently added new equipment as a result of its participation in the project FICTS1420-20, selected by the MINECO for co-financing by the FEDER Program in ICTS 2014-2020. The new equipment includes: Equipment of biopharmaceutical characterization of pulmonary formulations with Breath Simulator and Alberta Idealised Throat (AIT) NGI cascade Impactor: an analytical tool for the development of inhalation products. It’s use for the testing of all inhalation formulations and devices: MDIs, DPIs, nebulizers and aerosol and nasal sprays Malvern Spraytec: It’s a laser diffraction system allows measurement of spray particle and spray droplet[...]

23 Aug

Targeting antitumoral proteins to breast cancer by local administration of functional inclusion bodies

Three units of NANBIOSIS have collaborated in obtaining the research results published in the article “Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies” published by Advanced Science Protein production and DLS have been partially performed by the Unit 1 of ICTS NANBIOSIS Protein Production Platform (PPP) and the Unit 6 NANBIOBIS Biomaterial Processing and Nanostructuring Unit. Biodistribution and immunohistochemistry assays were performed at NANBIOSIS U20 In Vivo Experimental Platform/FVPR Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44‐targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types[...]

22 Aug


Next October 15-18, the researchers of NANBIOSIS U12, Nanostructured liquid characterization unit, are giving a course on Nano Technologies and Microencapsulation organized by CSIC General Foundation and CUIMPB – Center Ernest Lluch of the Menéndez Pelayo International University (UIMP) in Barcelona. The nano- and microencapsulation consists in the protection of active substances inside nano- and microcarriers, particularly labile molecules, improving their stability, with the aim of transporting them and achieving their controlled release. This topic is the subject of great interest in numerous fields and industrial applications. It is known that the performance efficiency of an active substance greatly increases[...]

21 Aug

AKT2 as a promising target for future anti-cancer therapies

The researchers of NANBIOSIS U20, led by Ibane Abásolo and Simó Schwartz have published a new article on the scientific magazine Cancers, with the title Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells All the in vivo studies were performed by NANBIOSIS U20 In Vivo Experimental Platform. Therapeutic resistance seen in aggressive forms of breast cancer remains challenging for current treatments. More than half of the patients suffer from a disease relapse, most of them with distant metastases. Cancer maintenance, resistance to therapy, and metastatic disease seem to be sustained by the presence of cancer stem[...]

20 Aug

New publication by scientists of NANBIOSIS Unit 6 aims to motivate scientific community to start a new research line for organic and bio-organic electronics focused on the device fabrication

Researchers of Nanomol Group, coordinator of NANBIOSIS U6 of CIBER-BBN and ICMAB-CSIC, led by Inma Ratera and Jaume Veciana have publish a new article titled “Reversible switching of the Au(111) work function by near infrared irradiation with a bistable SAM based on a radical donor–acceptor dyad“, at Journal of Materials Chemistry C. Article: https://pubs.rsc.org/en/content/articlelanding/2019/TC/C9TC00906J#!divAbstract[...]

17 Aug

The Autonomous University of Barcelona, in the elite of the 300 best universities in the world

The Academic Ranking of World Universities (ARWU), known as Shanghai Ranking, which was made public on August 15, places the Autonomous University of Barcelona among the elite of the 300 best universities in the world. This indicator organizes up to 20,000 university centers worldwide, based on transparent methodology and objective third-party data. ARWU is regarded as one of the three most influential and widely observed university rankings The Autonomous University of Barcelona houses two of NANBIOSIS Units: U1 Protein Production Platform (PPP), led by Toni Villaverde, Neus Ferrer and Paolo Saccardo, offer an “tailored” service for the design, production and purification[...]

16 Aug

The University of Zaragoza, in the elite of the 500 best universities in the world

The Academic Ranking of World Universities (ARWU), known as Shanghai Ranking, which was made public on August 15, once again places the University of Zaragoza among the elite of the 500 best universities in the world. This indicator organizes up to 20,000 university centers worldwide. Among the keys that have been able to positively influence the results of the research, according to the Vice Chancellor for Prospect, Sustainability and Infrastructure of the University of Zaragoza, Francisco Serón, are the increase in public campus funding for four years as well as the quality of their Scientists. The University of Zaragoza houses[...]

02 Aug

Scientific breakthrough against the problems of advanced age in fertility.

Researchers of CCMIJU. led by Javier G. Casado, Scientific Director of NANBIOSIS U14 Cell Therapy, are coauthors of the article “Extracellular vesicles derived from endometrial human mesenchymal stem cells enhance embryo yield and quality in an aged murine model” published by. Biology of Reproduction, The study of the beneficial effect of endometrial stem cell exosomes on embryonic quality has been developed in NANBIOSIS U14 and in collaboration with U22 and U23 Advanced age is a risk factor undermining women’s fertility. Hence, the optimization of assisted reproduction techniques is an interdisciplinary challenge that requires the improvement of in vitro culture systems. Here, w[...]

30 Jul

Nanomol group initiates contact with the AEMPS to bring a new treatment against venous leg ulcers to the clinic

Researchers of the Nanomol group, ICMAB-CSIC and CIBER-BBN members of the ICTS “NANBIOSIS”, specifically of the Biomaterial Processing and Nanostructuring unit (U6), together with the company Nanomol Technologies S.L. have begun a consultation process with the Spanish Association of Medicines and Health Products (AEMPS) to try and enter a new treatment in a clinical studies stage, to fight against venous ulcers in lower extremities. The study is carried out within the framework of the RIS3CAT NANONAFRES project. Approximately, 80% of ulcers in lower extremities have associated pathologies of venous insufficiency and these wounds are usually recurrent. An open ulcer can[...]

29 Jul

Making the most from Signals in Biomedical applications.

Last week took place on Berlin the EMB Conference 2019, (the 41st  International Engineering in Medicine and Biology Conference) with the overarching theme “Biomedical engineering ranging from wellness to intensive care” counting with plenary keynotes from leading academic and industrial scientists, who presented aspects of innovation and translational engineering in biomedicine. Pablo Laguna, Scientific Director of NANBIOSIS Unit 27, from CIBER-BBN and I3A-UZ, was invited to give a talk on the topic “Phisiologically Driven Biomedical Signal Processing: making the most of Signals” Pablo Laguna has co-authored more than 150 research papers on this topic, over 300 international conference papers, and has advise 15 Ph.D[...]

18 Jul


Last week, representatives of NANBIOSIS and OmicsTech met at the IQAC-CSIC facilities in Barcelona to exchange common research lines, points of view of their complementarity and collaboration possibilities of the facilities, both recognized as Unique Scientific Technical Infrastructure (ICTS) by the Spanish Government. The Infrastructure for Omics Technologies OmicsTech ICTS is a distributed infrastructure that offers researchers the possibility of using globally competitive singular facilities exclusively dedicated to work with omics technologies, with a spectrum of biomolecular analysis tools for holistic capture of biological processes, to support research, technological development, and innovation activities. Advances in genomics, proteomics and metabolomics technologies have opened[...]

18 Jul

Agreement signed with Spanish Goverment for the allocation of FEDER funds for NANBIOSIS ICTS

In the framework of the FEDER Program in ICTS 2014-2020, a projects related to the ICTS NANBIOSIS has been selected by the Ministry of Science, Innovation and Universities for co-financing with FEDER funds of the European Regional Development Funds program. An agreement has been signed between Ministry of Science, Innovation and University of Extremadura, institution that houses NANBIOSIS unit 16 for the co-financing of the Project FICTS1420-14-09: “Compra e instalación y puesta a punto de equipamiento de caracterización para complementar la Unidad 16 de NANBIOSIS – Surface Characterization and Calorimetry Unit –NANBIOSISU16”.[...]

27 Jun

Judit Tomsen: Best oral presentation at ESC 2019

Last June 18-22 at the 2019, ESC meeting, the European Students Colloid Conference, that took place in Varna, Bulgaria, Judit Tomsen,  PhD fellow at the Nanomol group from CIBER-BBN and ICMAB-CSIC, was awarded with the best oral presentation. Judit Tomsen, who carries out her work under supervision of Nora Ventosa,  Scientific Director of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit, presented her oral communication entitled “Design of peptide targeted nanovesicles for the α-galactosidase A enzyme delivery“. Her talk explained some of the smart4fabry european project results, a project coordinated by CIBER-BBN and Nora Ventosa in which participates NANBIOSIS Unit 6. The European Colloids and Interfaces Society (ECIS) organizes biannually ESC meetings of advanced students at PhD and MSc[...]

25 Jun

Do you want to join the nanotechnology revolution?

From the NFP research group of CIBER-BBN and INA, led by Jesus Santamaria, that coordinates NANBIOSIS U9 Synthesis of Nanoparticles Unit, and through the SAMCA Nanotechnology Chair, the call for grants has been launched: Nanotechnological Bonds For more information: http://capsulasdenanotecnologia.es/bonos-nanotec/[...]

24 Jun

NANBIOSIS U20 at the Nanomed Europe Conference, NME19.

Last week took place in Braga, Portugal, the Nanomed Europe Conference, NME19, a new and unique conference  born from the merge of the 14th annual event of the ETPN & the European scientific conference ENM (after London 2017 & Grenoble 2015), bringing together scientists, technology providers, entrepreneurs, industry and clinicians, all of them developing great medical applications of Nanotechnologies and emerging MedTech. The event is been co-organized this year by the ETPN and INL. Simó Schwartz, Scientific Director of NANBIOSIS U20, was one of the selected speakers and gave a lecture about “Preclinical development of magnetic nanoparticles for the treatment of pancreatic cancer” Two posters mentioning t[...]

21 Jun

Agreement signed with Spanish Goverment for the allocation of FEDER funds for NANBIOSIS ICTS

In the framework of the FEDER Program in ICTS 2014-2020, a projects related to the ICTS NANBIOSIS has been selected by the Ministry of Science, Innovation and Universities for co-financing with FEDER funds of the European Regional Development Funds program. An agreement has been signed between Ministry of Science, Innovation and UPV/EHU (University of the Basque Country ), institution that houses NANBIOSIS unit 10 for the co-financing of the Project FICTS-1420-17: “Purchase and installation and set-up of characterization equipment to complement Unit 10 of drug formulation”.[...]

12 Jun

Laparoscopic surgery in the uterus retrieval procedure during uterine transplantation

Researchers of NANBIOSIS units at JUMISC have recently published the results of an study that highlights the promising application of laparoscopy for graft procurement surgery in uterine transplantation from living donors for absolute uterine infertility treatment. Laparoscopy seems to be a safe, time saving, useful and technically feasible surgical procedure for uterus extraction, with the additional benefits of minimally invasive surgery. It was also demonstrated that after a successful uterine transplant, pregnancy can be achieved by combining laparoscopy for uterine retrieval and microsurgery for vascular anastomosis. With the increasing success rate of human uterus transplantation trials from living donors, it[...]

04 Jun

New Antimicrobial surfaces with self-cleaning properties and NANBIOSIS Unit 17

In the last decades, increased resistance to conventional antibiotics has led to important research in the development of alternative strategies for preventing pathogen dissemination. Antimicrobial surfaces containing a biocidal agent inhibit or reduce microorganisms growth capacity on the surface of materials. In addition to this microbial proliferation inhibition, antimicrobial coatings may also confer additional properties. Researchers from the University of Alcalá and the CSIC Institute of Catalysis and Petrochemistry, have carried out a research about the self-cleaning properties of antimicrobial surfaces functionalized by photocatalytic ZnO electrosprayed coatings. The authors prepared electrosprayed photoactive coatings of sol-gel ZnO nanoparticles tested as dua[...]

31 May

NANBIOSIS U27 propose a mew method for assessing nonlinear cardiorespiratory interactions

Researches of NANBIOSIS Unit 27 High Performance Computing, S. Kontaxis, J. Lázaro, E. Gil, P. Laguna, and R. Bailón are the authors of an article recently published by IEEE Transactions Biomedical Engineering Alternations of cardiorespiratory interactions are related to Autonomic Nervous System (ANS) dysfunction and physiological regulation of the Heart Rate Variability (HRV) in cardiovascular diseases. In this study, a method for assessing nonlinear cardiorespiratory interactions is proposed, quantifying the Quadratic Phase Coupling (QPC) between respiration and HRV. Quadratic cardiorespiratory couplings are studied during a tilt table test protocol on young healthy subjects. Results show a significant reduction of QPC[...]

30 May

NANBIOSIS unit 13 participation at the VIII Conference of Young Researchers of I3A-UZ

Next Thurstday, June 6th, the “Aragón Engineering Research Institute” (I3A) of University of Zaragoza will hold the “VIII Conference of Young Researchers” at the Conference Room Building. R & D (block 1, 1st floor) Researchers of NANBIOSIS unit U13 Tissue & Scaffold Characterization Unit will present their works In the oral presentations section, Mohamed H. Doweidar will talk about Cell behavior under hypoxic conditions. Computational 3D model. In the posters section in the area of ​​BIOMEDICAL ENGINEERING the researchers of unit 13 will present the following results. Design of a microfluidics system for the simulation of the formation of atheromatous[...]

29 May

Mechanism of interaction of a material (pharmaceutical, food, construction, chemical, etc.) with moisture or with any organic vapor.

Next June 11, 2019, from 09:30h to 17:00h, will take place in Eureka Building – Parc de Recerca, UAB (Barcelona), a Scientific-Theoretical / Practical Workshop on: DYNAMIC SORPTION OF VAPORS (DVS – DYNAMIC VAPOR SORPTION) AND CHARACTERIZATION OF MATERIALS (iGC / SEA – INVERSE GAS CHROMATOGRAPHY / SURFACE ENERGY ANALYZER) FOR THE ANALYSIS OF THE SORTION OF WATER AND ORGANIC VAPORS, AND CHARACTERIZATION OF MATERIALS AND SURFACES. The event is organized by IESMAT, S.A. in collaboration with Nanomol Technologies SL, the Institute of Materials Science of Barcelona (ICMAB-CSIC), Surface Measurement Systems (SMS) and the Center for Biomedical Research in Network[...]

24 May

Quantification of Ventricular Repolarization Variation for Sudden Cardiac Death Risk Stratification in Atrial Fibrillation

ATRIAL fibrillation (AF) is the most prevalent sustained arrhythmia and it has become one of the most important public health issues in developed countries. It is expected to double its incidence by 2030 [1], [2], representing the major cause of hospitalizations in elderlies (≥65 years), together with chronic heart failure Alba Martín-Yebra and Juan Pablo Martínez, scientists of NANBIOSIS U27 High Performance Computing, have led the research that proves that it is possible to stratity AF patients at risk of sudden cardiac death (SCD) what could help cardologists to implement better solutions. The computation was performed by the ICTS NANBIOSIS,[...]

23 May

Preclinical molecular imaging and its application to biomedical research

During the days 22-24 of May is taking place in Madrid the 3rd Workshop of introduction to the preclinical molecular image and its application to biomedical research,. The wokshop has been organized by the Health Research Institute of the Gregorio Marañón Hospital, the Complutense University of Madrid and the Madrilenian Network of nanomedicine in molecular imaging (RENIM-CM). The program counts with theoretical sessions of introduction to the physical foundations of each one of the modalities of image and its applications to preclinical biomedical research, as well as practical demonstrations of said image techniques. Ibane Abásolo, Scientific Coordinator of Unit 20[...]

22 May

An Eskimo in the desert

An Eskimo in the desert is the title of the talk that Ignacio Ochoa Researcher of NANBIOSIS U13 Tissue & Scaffold Characterization Unit is giving today at the Pint of Science Festival in Zaragoza at 19:00. One of the greatest advances in biomedicine was to achieve, at the end of the 19th century, maintain human cells outside the body in order to study them. This breakthrough has allowed us, for example, to discover new drugs and evaluate the toxicity of many compounds. Unfortunately, this progress has hardly evolved over these 125 years. However, the arrival of microfluidic technology has allowed[...]

21 May


Francisco Miguel Sánchez Margallo, Scientific Director of the Minimally Invasive Surgery Center ‘Jesús Usón’ and Deputy Director of NANBIOSIS, leads, together with Thomas Malone, of the Massachusetts Institute of Technology (MIT), in the United States, the project selected by the MIT program -Spain ‘La Caixa’ Foundation Seed Fund “Developint a sensor framework for minimally invasive surgery”. The project seeks to develop a system of sensors to analyze health parameters of the surgeon, such as his physiological and ergonomic state, as well as the interaction between this and the patient during surgery. It is a disruptive research project on sensors to[...]

20 May

Multiparametric MR approaches for non-invasive glioblastoma therapy response follow-up (MAGRes)

Ana Paula Candiota, Scientific coordinator of U25 of NANBIOSIS, is the IP of the granted project Multiparametric MR approaches for non-invasive Glioblastoma therapy response follow-up (MAGRes), selected for funding in the ATTRACT call https://attract-eu.com/the-project/ The kick-off meeting for is taking place at CERN, Switzerland, days 20-21th May with talks of all selected projects. Unit 25 will have a relevant role in the development of MAGRes. MRI/MRSI from preclinical brain tumors will be acquired at NANBIOSIS U25, NMR: Biomedical Applications I[...]

17 May

Job Vacancy for position of Project Manager at CIBER

Scientist aiming at developing a career in project management is required for a European Project in the field of biomedical research; working with NANBIOSIS ICTS (Scientific infraestructure of CIBER-BBN). The position requires good command of English and strong skills in coordinating researchers. Applications must be filed at CIBER’s web portal untill May 22.[...]

16 May

Safe-N-Medtech kicks off in Bilbao

The Safe-N-MedTech European Project kcks off in Bibao to create an open innovation platform that accelerates the development of medical devices based on nanotechnologies. During 2 and 3 of May took place in Bilbao, at the University of the Basque Country, the kick off meeting of the European project Safe-N-Medtech organized by Osteba, the HTA Unit of the Ministry of Health of the Basque Country (Spain) in collaboration with BIOPRAXIS-BIOKERALTY. Safe-N-Medtech, counts with 28 partnerts coordinated by TECNAN (Navarran company with great experience in Nano products), together with BIOPRAXIS-BIOKERALTY, the research branch of the global health companies Keralty and Praxis.[...]

14 May

Diabetes mellitus type 1: new system for treatment

The research carried out by the NanoBiocells group, coordinator of NANBIOSIS U10 Drug Formulation unit, from CIBER-BBN and UPV-EHU, with BIOMICS group of UPV-EHU was yesterday highlighted in Catalunya Vanguardista and Noticiasdelaciencia.com. The research reduces the volume of implantation of microcapsules containing insulin-producing pancreatic cells by almost 80% thanks to an innovative system of Magnetic separation of microcapsules. In this way, the medical complications derived from the implantation of large volumes of microcapsules decrease and the treatment of type 1 diabetes mellitus improves. More information: https://www.catalunyavanguardista.com/nuevo-sistema-para-el-tratamiento-de-diabetes-mellitus-tipo-1/[...]

13 May

Biomedical devices with natural fluorescence for monitoring in the body

Researchers from the NanoBioCel and the ICTS NANBIOSIS through the Drug Formulation Unit 10 of CIBER-BBN and the University of the Basque Country (UPV/EHU), together with the University of Michigan (USA), have developed a biomedical cellular immunoisolation device (microcapsules) with intrinsic capacity to be traced once implanted in the organism. The novel design incorporates a natural substance called genipine, which emits intense and stable fluorescence in the far red range. Drug Formulation Unit 10 of Nanbiosis has worked in the design and development of fluorescent particles for use in experimental animals. Non-invasive monitoring of implanted hydrogel-based biosystems generally requires indirect[...]

08 May

CIBER offers two Degree positions for NANBIOSIS (Project Mananger and Researcher) in the frame of a H2020 project.

CIBER-BBN offer two possitions for a project manager (PRF-1768 https://www.ciberisciii.es/empleo/detalle-oferta?id=1768 )  and a researcher (PRF-1766 https://www.ciberisciii.es/empleo/detalle-oferta?id=1766) CIBER is looking for candidates for the selection of a project manager (https://www.ciberisciii.es/empleo/detalle-oferta?id=1768) and a researcher (ttps://www.ciberisciii.es/empleo/detalle-oferta?id=1766) to work in the framework of a European H2020 project. SAFE-N-MEDTECH is an Open-Innovation Test Bed for Safety Testing of Medical Technologies for Health – H2020 NMBP (Nanotechnologies, Advanced Materials, Biotechnology and Advanced Manufacturing and Processing) medtech project, that has just been launched. The project SAFE-N-MEDTECH will build an innovative open access platform providing reference laboratories and companies with the capabilities, know-how, networks and services needed for developing, testing, evaluating, optimizing and[...]

07 May

The first Nanocomposite that slows the spread of colon cancer

The creation of a nanodrug capable of blocking the spread of the disease, which is known as metastasis, has been highlighted by Guia Medica, as a heavy blow struck against to colon cancer, the malignant tumor with the highest incidence in our country, a process that affects 40% of the million cases of this type of cancer that are diagnosed every year in the world, and that represents the main cause of death. The research, jointly carried out by scientists from the IIB Sant Pau, Sant Pau Hospital, the UAB, CSIC and CIBER-BBN, led by Esther Vázquez and Antonio Villaverde, Strategy[...]