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26 Feb

Fabry disease & Smart4Fabry project

The Fabry disease (FD) is a lysosomal storage disorder (LSD) that currently lacks an effective treatment. Lysosomes are spherical vesicles, which contain hydrolytic enzymes found in nearly all animal cells. LSDs are caused by lysosomal dysfunctions, usually because of the deficiency of a single enzyme required for the metabolism of macromolecules such as lipids, glycoproteins and mucopolysaccharides. Fabry disease is a progressive, X-linked inherited disorder caused by deficiency or absence of the α-galactosidase A (GLA) activity, an enzyme involved in the glycosphingolipid metabolism. The substrates of GLA are glycosphingolipids, being the primary substrate the globotriaosylceramide (Gb3). Therefore, the failure of GLA activity leads[...]

04 Feb

NANBIOSIS Against Cancer

The World Health Organization, the International Cancer Research Center (IARC) and the International Union Against Cancer (UICC) celebrate February 4 of each year as World Cancer Day Every year, 14 million new cases of cancer are diagnosed worldwide and the disease causes 8.2 million deaths. Thanks to scientific research, great advances have been made in the fight against cancer. Through surgery, chemotherapy or radio therapy and, in the last 20 years, through immunotherapy, hormonal treatment or cell therapies, tools have been obtained to improve early diagnosis and treatments, increasing cancer survival by 20%. The only way to understand cancer and,[...]

14 Nov

Drive Pannel Diabetes - Nanbiosis
Diabetes mellitus and pancreatic islet transplant: DRIVE

Today in the World Diabetes Day it is a good moment to remember The Patient Panel of the European project DRIVE- Diabetes Reversing Implants, held in Vitoria (Alava) on June 2 where researches and doctors met with patients and families. The Panel was organized by the NanoBioCel group of CIBER BBN and NANBIOSIS Unit 10 Drug Formulation, with the purpose of letting know the DRIVE project to patients and concect patients with the project scientists and experts in pancreas and stem cell transplantation. Thus, one of the most important health objectives of the European Union was met: to promote direct[...]

19 Jul

Mechanical Characterization of soft biological tissues - Nanbiosis
Mechanical Characterization of soft biological tissues

The experimental study of the mechanical properties of biological tissues is of vital importance. Thorough research into themechanical response of biomaterials is the basis for the creation ofmodels which can accurately reproduce the mechanical behavior ofsuch materials. Adequate mechanical characterization of tissue materials is of paramount interest to the clinical simulations, diagnostic and tissue engineering fields – where the tissue structure, in contrast to classical mechanics application fields, is just simply a biological tissue. In order to obtain their material properties, classical engineering testing techniques have been applied to biologicalmaterials. To reproduce the mechanical behavior of these kinds ofmaterial, many[...]

16 Jan

U12-Nanostructured liquid characterization unit
Characterization of nanomedicines

The quick development of nanotechnology and its application in medicine have generated new alternatives for the diagnosis and treatment of diseases thanks to the novel methods of preparation, modification and characterization of nanomaterials. The knowledge about the behavior of matter at the atomic and molecular level has allowed the creation of tools and processes to observe manipulate and control biological structures on a scale between 100 and 10,000 times smaller than a mammalian cell. Nanomedicine is defined as the application of nanotechnology in view of making a medical diagnosis or treating or preventing diseases. It exploits the improved and often[...]

News about Nanbiosis

30 Nov

2020 Rei Jaume I Awards ceremony – Laura Lechuga NANBIOSIS U4-

This monday 30 of october has taken place the traditional ceremony of Rei Jaume I Awards in Valencia, granted to six professionals in research, science and economics. At the ceremony, the awards have been given to the winners of the six categories: Rei Jaume I Basic Research Prize 2020 to Fco. José García Vidal; Rei Jaume I Economy Prize 2020 to Diego Puga; Rei Jaume I Medical Research Prize 2020 to Miguel Beato del Rosal; Rei Jaume I Environmental Protection Award 2020 to Fernando T. Maestre; Rei Jaume I New Technologies Award 2020 to Laura Lechuga and Rei Jaume I[...]

29 Nov

Nb4D group- NANBIOSIS U2 receives the acreditation TECNICO, in the on line event organizes by ACCIO

Las November 27 was held the ACCIO ceremony (on line this year due to the Covid Pandemic restrictions) of disclosure of new TECNIO accreditations. Aurea Rodriguez, Director of Business Innovation at ACCIO has welcomed the attendees to the event. Later, the TECNIO program Coordinator, Marta Peidro, presented the background and rationale for this accreditation for excellence groups in technology transfer in Catalonia. This year there have been five new groups from among all Catalan universities and research organizations, which have obtained the TECNIO accreditation for the first time, making a total of fifty-four groups accredited in 2020. The event continued[...]

26 Nov

Two new equipment items at the U6 of Nanbiosis with cofinancing from FEDER funds

The U6 of NANBIOSIS (Biomaterial Processing and Nanostructuring Unit) has expanded its capabilities with 2 new equipment items for the characterization unit. Both equipment items will allow the characterization of some physico-chemical properties of different nanomaterials. The Zetasizer ULTRA is used to measure the particle size of dispersed systems from sub-nanometer to several micrometers in diameter, using the technique of Dynamic Light Scattering (DLS). Zetasizer systems are also used to analyze particle mobility and charge (Zeta potential) using the technique of Electrophoretic Light Scattering (ELS), and the molecular weight of particles in solution using Static Light Scattering (SLS). The Green[...]

26 Nov

The Nanomedicine Revolution

Yesterday, November, 25 took place, within the the program of the Ateneo of the EINA (School of Engineering and Architecture of Aragón), the online conference on “The Revolution of Nanomedicine” by Ramón Martínez Máñez. The Conference chair, Jesús Martínez de la Fuente, Principal Investigator of the BIONANOSURF group of CIBER-BBN and the Institute of Nanoscience and Materials of Aragón, introduced the guest, Ramón Martínez Máñez, Scientific Director of CIBER-BBN, highlighting “his creativity in the use of his systems and how he combines them with different diagnostic release systems, combining organic chemistry, surface chemistry, applications in biotechnology and giving way to[...]

25 Nov

NANBIOSIS U12 expands its capabilities with a new SEM for morphological and dimensional characterization of solid samples

The U12 of NANBIOSIS (Nanostructured liquid characterization unit) has expanded its capabilities with a new equipment U12-E22. SEM Hitachi TM4000Plus II for morphological and dimensional characterization of solid samples Low vacuum Scanning Electron Microscopy with two electron detectors (secondary, SE, and backscattered, BSE). SE imaging provides a detailed information of the morphology of the sample and BSE gives information about the different components of the sample, based on the different atomic number (the higher the atomic number, the brighter the surface). The equipment can apply different vacuum levels (using a turbo molecular pump) with accelerating voltages between 5 and 20[...]

23 Nov

NANBIOSIS-ICTS AT CASEIB 2020

The XXXVII Annual Congress of the Spanish Society of Biomedical Engineering (CASEIB) is taking place between November 25 and 27. This new edition of CASEIB, in virtual format is organized by the CIBER-BBN group of Biomedical Engineering at Valladolid Universitiy, led by Prof. Roberto Sánchez Hornero. Prof. Laura Lechuga, Scientific Director of NANBIOSIS U4 Biodeposition and Biodetection Unit, member of the advisoty committee of scientific experts (Multidisciplinary Working Group) to the Ministry of Science and Innovation in COVID-19 and coordinator of the European project CONVAT shall participate in the Roundtable I: Biomedical Engineering and COVID-19 November 26, 12:00 h Researchers of BSICoS[...]

22 Nov

Closer to understand the regulation of SMARCA4 expression

Researchers of NANBIOSIS U29 Oligonucleotide Synthesis Platform (OSP) from CIBERBBN at @IQAC_CSIC, led by Prof. Ramón Eritja, are the authors of an article published by Int J Biol Macromol. 2020, entitled “Influence of pH and a porphyrin ligand on the stability of a G-quadruplex structure within a duplex segment near the promoter region of theSMARCA4 gene”. Prof Eritja hightlighs the contribution to this work by Dr. Raimundo Gargallo from the University of Barcelona. The manuscript described the structural analysis of the promoter region of the SMARCA4 gene involved in ovarian cancer. This promoter region has an exceptionally long G-rich sequence.[...]

21 Nov

Moore4Medical a project to accelerate innovation in electronic medical devices

The NanoBioCell group, led by Prof. Jose Luis Pedraz, participates in the European project Moore4medical. A project to accelerate innovation in emergencing medical devices with open tecnhology platforms. The NanoBiocel group, will focus on the lyophilization process of biopharmaceuticals and their use in microfluidic devices The NanoBiocel research group of the University of the Basque Country / Euskal Herriko Unibertsitatea, which is part of the CIBER BBN and the ICTS Nanbiosis through the U10 Drug Formulation Unit, and led by Professor Jose Luis Pedraz of the Faculty of Pharmacy, participates in the European project Moore4medical, which aims to accelerate innovation[...]

20 Nov

Understanding human heart behaviour with mathematics and engineering.

Researchers from the I3A and the CIBER-BBN at the University of Zaragoza Esther Pueyo and Konstantinos Mountris have been interwiewed at the Radio program “Hoy por Hoy” LA SER in relation with their work from engineering and mathematics to understand the functioning of the heart when it is healthy and when a heart attack occurs, to provide clinical specialists with the tools needed to improve patient care. They do this through computing in cardiology using the instalations of the ICTS Nanbiosis U27 High Performance Computing Unit, with the creation of a virtual heart that allows the computer to reproduce t[...]

19 Nov

Ainhoa González Pujana, NANBIOSIS U10, 2019 best doctoral thesis award by the Bioaraba Research Health Institute

The Bioaraba Health Research Institute has awarded Ainhoa ​​González Pujana, a researcher at NanoBioCell and the Nanbiosis Platform through the U10 Drug Formulation (from CIBER-BBN and UPV-EHU), the award for the best doctoral thesis 2019 at the XXI Bioaraba Research and Innovation Conference, held last November 5 in Vitoria-Gasteiz. Along with the recognition, the award consists of an economic endowment of € 1,000 in funds for R + D + i. The thesis, directed by Professor Rosa María Hernández and Dr. Edorta Santos Vizcaíno, has been carried out in the NanoBioCel group of the Faculty of Pharmacy of the University[...]

18 Nov

New Webinar: Introduction to regulatory aspects of in vitro diagnostic (IVD) medical devices

On November 25th, CIBER-BBN organized a new webinar on regulatory aspects of in vitro diagnistic (IVD) medical devices. The European Parliament, in 2016, approved the new regulations that redefined the development of In Vitro Diagnostic (IVD) methods, with the aim of providing a framework of greater safety and transparency for patients, and at the same time renewing the regulations in force in that moment. This conference is aimed at researchers from the Academy, or any professional interested in clarifying the most important changes in regulations for the development of IVD products. We will have the participation of experts from t[...]

17 Nov

Update on biomaterials, bioengineering and nanomedicine, with a focus on COVID-19, at the annual CIBER-BBN conferences

National and international leading researchers have addressed this Monday and Tuesday the main scientific advances and challenges in the areas of bioengineering, biomaterials and nanomedicine. For yet another year, the XIV CIBER-BBN Annual Conference, held online, has brought together all the scientific groups in this area of ​​the ISCIII Center for Online Biomedical Research (CIBER). The conference was opened on Monday by the director of the ISCIII, Raquel Yottti, who highlighted the role of the CIBER-BBN investigation “to find answers to very complex problems, specifically this year in the field of the fight against the pandemic.” The scientific director of[...]

16 Nov

Laura Lechuga: awarded the most important recognition in Spain in the field of scientific research

The Scientific Director of NANBIOSIS U4 Biodeposition and Biodetection Unit Laura Lechuga, has been awarded the 2020 National Research Prize, the most important recognition in Spain in the field of scientific research, granted by the Ministry of Science and Innovation. The National Research Awards, created in 1982, aim to distinguish the merit of those researchers of Spanish nationality who are carrying out outstanding work in scientific fields of international relevance and who exceptionally contribute to the advancement of science, to the transfer of technology and the progress of humanity. These awards have a total amount of 300,000 euros, (30,000 euros[...]

13 Nov

How to delay vision loss in hereditary retinal dystrophies? Looking for the most effective and economical pharmacological nanotherapy

Researchers from the CIBER-BBN and NANBIOSIS are participating in a new project that aims to achieve the most effective, specific and economical pharmacological nanotherapy that allows delaying the death of retinal cells and subsequent loss of vision in hereditary retinal dystrophy. retinitis pigmentosa, regardless of the genetic defect causing the disease. In this project, coordinated by the researcher Regina Rodrigo, the ONCE and the Prince Felipe Research Center (CIPF) of Valencia collaborate, together with researchers from the CIBER of Rare Diseases (CIBERER) and the Manises Hospital in Valencia. On behalf of the CIBER-BBN, the scientific director, Ramón Martínez Máñez, together[...]

13 Nov

Nb4D group – NANBIOSIS Unit 2 CAbS – accredited with the TECNIO seal

The Nb4D group of CIBER-BBN and IQAB-CSIC, coordinator of NANBIOSIS Unit 2 Custom Antibody Service (CAbS), has been accredited with the TECNIO seal. This accreditation is the hallmark TECNIO granted by the Government of Catalonia, through ACCIÓ, to identify the developers and facilitators of differential technologies in Catalonia. TECNIO is the umbrella brand for catalan technology centres and university research groups dedicated to industrial research and technology transfer. ACCIO, CERTIFICATION, QUALITY MANAGEMENT SYSTEM[...]

12 Nov

NANBIOSIS in the new poster of ICTS map published by Spanish Goverment.

ICTS underpins the Spanish reputation for research excellence. In the picture: the new poster of the ICTS map in which NANBIOSIS facilities have been highlighed with a red square The term Unique Scientific and Technical Infrastructure (ICTS) refers to facilities, resources, or services for the development of top-quality cutting-edge research, as well as the communication, exchange, and preservation of knowledge, the transfer of technology, and promotion of innovation. They are unique or exceptional in their fields, with a high cost of investment, maintenance, and operation, and are of a strategic importance that justifies their availability to all actors in t[...]

12 Nov

Third edition of the course on “Characterization techniques for Particulate Materials” with Amable Bernabé

The Soft Matrials Lab at ICMAB-CSIC, run by Amable Bernabé (NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit, hosted from Monday, 5 October, to Wednesday, 7 October a course on “Characterization techniques for particulate materials”. The course was an introduction to different techniques to characterize nanoparticles and other particulate matter, including the basic fundamentals, sample preparation, practical examples and results interpretation.  Due to the COVID-19 pandemic, the participants of the course were less than in previous years, and during the practical sessions the group was divided, so less people was at the same time inside the lab, and the safety measures could be kept.  Theory: Dynamic Light[...]

11 Nov

Laura Saenz del Burgo, NANBIOSIS U10, award for the best emerging researcher at the XXI Bioaraba Research and Innovation Conference

The CIBER-BBN researcher at the University of the Basque Country (UPV-EHU), Laura Saenz del Burgo, received, within the framework of the XXI Bioaraba Research and Innovation Conference, the award for the “Best Emerging Researcher 2020”. The researcher of the NanoBioCel group of the UPV / EHU, who belongs to the CIBER BBN and the U10 Drug Formulation of the ICTS of Nanbiosis, is an active part within the research group led by Jose Luis Pedraz and focuses her work in the areas of Regenerative Medicine , Tissue Engineering and 3D-Bioprinting. The conference was held at the Palacio de Congresos d[...]

10 Nov

Regenerating ankle joints with collagen- and gelatine-based implants

 TRIANKLE is an EU Project to develop regenerative therapies for ankel injuries in which participate NanoBioCell Group and NANBIOSIS U10 Drug Formulation unit (from CIBER-BBN and UPV/EHU), led by José Luis Pedraz. The main objective is to reduce the time of recovery down to 50% andincrease the functionality ratios up to 10-15%. Research consortium is composed of 12 partners from 5 European countries and counts with a EU funding of €5.9M. It is expected that the results of the project will be very well received by potential patients, such as elite athletes and patients with osteoarthritis, through the outreac[...]

09 Nov

CIBER-BBN and NANBIOSIS at CIBEREDH Scientific Annual Meeting

José Becerra Ratia, Subdirector of CIBER-BBN and researcher of NANBIOSIS, has presented NANBIOSIS-ICTS at the online annual conference of CIBEREH research, which takes place from 9 to 11 of November 2020. José Becerra has explained an initiative of CIBER-BBN, already successfully launched with other CIBER thematic areas such as “seed projects” between research groups from two areas, in this case -BBN (Bioingniering, Biomaterials an Nanomedicine) and – EHD (Hepatic and Digestive Diseases) Professor Becerra has also presented CIBER-BBN as well as the opportunities offered by the ICTS NANBIOSIS as a Platform for Research and Biomedical Innovation. CIBEREHD counts with: 50 groups of[...]

08 Nov

III Course on Introduction to research and laboratory techniques in Biosciences

CCMIJU has organised the III Course on Introduction to research and laboratory techniques in Biosciences, which wil take place at JUMISC on December, 18th, 2020 under the Direction of Esther López Nieto and Javier García Casado, Scientific Director of NANBIOSIS U14 Cell Therapy. Other researchers of NANBIOSIS Units offer their expertise as Beatriz Moreno Lobato, Scientific Diector NANBIOSIS U19 and Luis Dávila Gómez, Scientific Director of NANBIOSIS U22 The course contents are distributed in the following blocks: Block I. Knowledge pills for research – TheoryResearch career and aid for hiring (Dr JG Casado). 30 minCommunication of research results (Dra. E López). 30 minIntroduction to[...]

08 Nov

Jesús Santamaría, Scientific Director of NANBIOSIS Unit 9, candidate to the Rectorate of the University of Zaragoza

Jesús Santamaría, Scientific Director of NANBIOSIS U9, Synthesis of Nanoparticles Unit, runs for the elections to the Rectorate of the University of Zaragoza. Jesús Santamaría Ramiro, professor in the Department of Chemical Engineering and Environmental Technologies, at the Faculty of Sciences, has presented his candidacy to the Rectorate of the University of Zaragoza this week. The opinion group Proyecto Unizar, the germ of this candidacy, has also been presented. Proyecto Unizar, which motto is “Another University is possible” includes more than 60 members of the university community and more than a hundred supporters, among them, several members of CIBER-BBN NANBIOSIS Units in[...]

05 Nov

How to take advantage of the body’s natural processes to create innovative therapies?

During the month of October took place the Spanish Society of atherosclerosis (SEA 2020) Virtual meetings, promoted by Novartis. Prof. Ramon Eritja, Scientific Director of NANBIOSIS U29 Oligonucleotide Synthesis Platform (OSP) (from CIBERBBN at IQAC_CSIC), was the guess speaker in the session “Innovation and future therapeutic strategies in dyslipidemia” giving the conference entitled “How to take advantage of the body’s natural processes to create innovative therapies“, in the telematic congress of the Spanish society of atherosclerosis (SEA 2020) in the session “Innovation and future therapeutic strategies in dyslipidemia”.Dr. Ramon Eritja, explained the mechanism of action of some new drugs based[...]

04 Nov

CIBER-BBN´s XIV Annual Conference

CIBER-BBN´s Annual Conference will take place from Monday, November 16, 2020 to Tuesday, November 17, 2020. This year´s edition includes presentations of internal collaborative projects, three plenary talks given by acknowledged experts in the fields of Biosignal Analysis, Hybrid Nanomaterials and Drug Delivery, a session dedicated to COVID-19 and the most recent advances in the fight against it as for detection, prevention and therapy and a session about the ICTS NANBIOSIS. Due to this year´s exceptional circumstances, XIV CIBER-BBN Conference will be held on-line. Access to broadcasted talks and subsequent debate is free following registration to the event https://jornadasanuales.ciber-bbn.es. Registration[...]

02 Nov

Prof. Pilar Marco, in the program “Meridiano Turing” of RTVE explains the COVID-19 tests.

The last edition of the program “Meridiano Turing” of RTVE interviews Maria Pilar Marco Head of CIBER-BBN and IQAC-CSIC group Nb4D and NANBIOSIS-ICTS Unit 2 Custom Antibody Service (CAbS), Cesar Fernández (Head of the Chemical Transducers Group at IMB-CNM, CSIC) and María Cruz Minguillón (EGAR group at IDAEA) Pilar Marco y César Fernández, the authors of the block of the CSIC’s report entitled “Containment and diagnosis“, explain wich is the best way to diagnose COVID and how reliable are the tests in this moment. What is needed is to detect an infection -says Pilar Marco- is viral material and w[...]

23 Oct

CLINAM 2020: Clinical Nanomedicine and the Impact of Digitalization and Artificial Intelligence for Precision Medicine

CLINAM, the European Foundation for Clinical Nanomedicine will celebrate on October 26 – 28, 2020 the 12th European and Global Summit for Nanomedicine with the subject Clinical Nanomedicine and the Impact of Digitalization and Artificial Intelligence for Precision Medicine. The Technologies for Diagnosis & Therapy in Patient-Centric Medicine The Conference will take place in Live Stream, due to the COVID-19 pandemic. NANBIOSIS will participate in the Virtual Enhibition and in the poster session with a poster “Cutting Edge Biomedical Solutions in Health for Translation into Clinics”. Also Prof. Simó Schwartz, Scientific Director of NANBIOSIS U20 In vivo Experimental Platform, will giv[...]

22 Oct

Researchers of NANBIOSIS U3 working in a project to develop molecules with neutralizing properties of SARS-CoV-2

The research group of Chemical Multivalent Systems for Nanomedicine and NANBIOSIS U3 Sinthesys of Peptides Unit, of IQAC-CSIC and CIBER-BBN, participates in a new project that seeks to develop molecules with neutralizing properties of SARS-CoV-2, the cause of the COVID-19 disease, for the treatment of patients requiring hospitalization and clinical supervision due to the severity of the infection. The project, led by the Public University of Navarra (UPNA) and Navarrabiomed, counts with the participation of researchers from institute of advanced chemistry of catalonia (Institute of Advanced Chemistry of Catalonia), IRB Barcelona (Institute for Biomedical Research), CIBER-BBN (Center for Networked Biomedica[...]

21 Oct

Electrochemical sensors for cortisol detections: Almost there

Researchers of NANBIOSIS Unit 8 Micro– Nano Technology Unit at the Microelectronic Institute of Barcelona, (of IMB-CNM, CSIC / CIBER-BBN) has recently published a review in the TrAC Trends in Analytical Chemistry entitled “Electrochemical sensors for cortisol detections: Almost there” highlighting: Overview of electrochemical techniques for cortisol detection published in the last five years. Recent advances in cortisol detection by electrochemical immunoassays. Potential of biosensing techniques for cortisol detection in biological matrices. Importance of cortisol quantification for clinical applications. Abstract Mostly known as “the stress hormone”, cortisol has many essential functions in humans due to its involvement in regulation of[...]

20 Oct

Laura Lechuga awarded the 2020 Rei Jaume I Prize in New Technologies

The Valencian Government (Generalitat Valenciana), together with the Foundation Premios Rei Jaume I, announced today the awardees of the 32th edition of the Rei Jaume I Awards, one of the highest recognitions for a research career in Spain. Prof. Laura M. Lechuga Gomez, Full Professor of the Spanish National Research Council (CSIC), head of the NANBIOSIS U4 Biodeposition and Biodetection Unit  and the Nanobiosensors and Bioanalytical Applications Group (of CIBER-BBN and the ICN2), has received the New Technologies Award. Prof. Laura M. Lechuga received her PhD in Chemistry from the University Complutense of Madrid (Spain) in 1992. The principal focus of her researc[...]

19 Oct

Novel Quatsome nanovesicles, prepared using compressed CO2, for the development of advanced nanomedicines

Guillem Vargas Nadal, researcher at Nanomol Group – NANBIOSIS U6 (ICMAB-CSIC and CIBER-BBN) and Nanomol Technologies will defend his PhD thesis on Friday, 23 October 2020, at 11 am in an online session. The PhD Thesis Defense will be held by videoconference from the ICMAB Meeting Room.  Further information and Registration to attend the PhD Thesis defense via Zoom nanoparticles at ICMAB-website. Supervisors: Nora Ventosa (Scientific Director of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit and leader of Nanomol Group of CIBER-BBNLidia Ferrer (Nanomol Technologies S.L.) Abstract: The nanovesicles are being developed and investigated to be used in the pharmaceutical world to deliver drug and detect[...]

18 Oct

Women Technologist Ada Byron Award to Laura Lechuga, Scientific Director of NANBIOSIS U4.

The organizing committee and jury of the seventh edition of the Ada Byron Prize for Technological Women, from the Faculty of Engineering of the University of Deusto, have awarded the 2020 award to Prof. Laura Lechuga Scientific Director of Nanbiosis U4 Biodeposition and Biodetection Unit of ICN2-CSIC and CIBER-BBN. Laura Lechuga has a degree in Chemical Sciences and is currently a research professor at the CSIC of Barcelona, Head of the Group of Nanobiosensors and Bioanalytical Applications. Her research area focuses on Nanomedicine, Nanodiagnosis and the technological development of nanophotonic biosensors and their integration into portable Point-of-Care (POC) platforms, as[...]

16 Oct

Job offer: FULLY-FUNDED PhD FELLOWSHIP at the University of Zaragoza

BSICoS Group at I3A- University of Zaragoza –NANBIOSIS U27 High Performance Computing offer a FULLY-FUNDED PhD FELLOWSHIP Applications must be submitted before October 27th, 2pm (Spain time).  Profile of the candidate:Graduate/Master in Mathematics, Physics, Engineering or related disciplines.  PhD contract and topic:A PhD contract (former FPI program) is offered for a PhD position at the Biomedical Signal Interpretation and Computational Simulation (BSICoS) group of the Aragón Institute of Engineering Research, University of Zaragoza.The PhD thesis is associated with the research grant “Towards improved management of cardiovas-cular diseases by integrative in silico-in vitro-in vivo research into heart’s structure, function and autonomic regulation”, funded by[...]

09 Oct

#QueSigaLaCiencia #ScienceMustGoOn!

#Quesigalaciencia is an initiative of the Centro de Investigación Biomedica en Red (CIBER), partnert of NANBIOSIS) to convey, from the optimism, the importance of continuing to research. From this initiative, CIBER researchers are encouraged to disseminate videos explaining their work and why it is important. The campaign will begin during the Madrid Science Week, but will continue later. To participate, consult the terms of the call The deadline for the call # QuéSigaLaCiencia is October 13 The Science and Innovation Week in Madrid is an event for scientific dissemination and citizen participation that aims to actively involve citizens in science, technology and innovation[...]

09 Oct

Workshop “Translational issues in nanomedicine” with NANBIOSIS U6 researchers at ETPN2020

ETPN2020, the 15th annual event of ETPN, European Technology Platform on Nanomedicine will take place, fully virtual on Oct. 14-15 to share the latest trends and success stories in Nanomedicine and emerging Medtech. In the frame of ETPN2020, on thursday Oct, 15, 12:00 will tak place the Workshop “Translational issues in nanomedicine” the workshop “Translational issues in nanomedicine” organized jointly by ETPN2020 and NMBP projects. Nora Ventosa, Scientific Director of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit, will participate as coordinator of the european project Smart 4 Fabry The workshop chairs will be Fabrice Navarro (Head of Laboratory at CEA[...]

08 Oct

New test trials to diagnose Covid 19: Ramon Martinez, Scientific Director of CIBER-BBN is interviewed by Spanish Television

Ramón Martinez, Scientific Director of CIBER-BBN and NANBIOSIS unit 26 NMR: Biomedical Applications II is interviewed by Spanish Television about the research he is coordinating at the Polytechnic University of Valencia to develop new tests as an alternative to PCR. Dr. Elena Aznar CIBER researcher at IQMA-IDM-UPV group explains how work these test that allow to diagnose quickly, easily, reliably and cheaply if a person is or has been infected by the SARS-COV-2 virus. Ramón Martínez Máñez, leader of the project, reports on the point where the investigation is, as well as the difference of these tests with PCR or[...]

06 Oct

Impact of Extracellular Vesicle Isolation Methods on Downstream miRNA Analysis in Semen

An article by Sara Larriba of the Human Molecular Genetics Group of Bellvitge Biomedical Research Institute (IDIBELL), recently published by the International Journal of Molecular Science. entitled “Impact of Extracellular Vesicle Isolation Methods on Downstream miRNA Analysis in Semen: A Comparative Study“, acknowledges NANBIOSIS ICTS for its participation in the research results. The nanoparticle tracking analysis was performed by the ICTS NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit. Abstract: Seminal plasma (SP) contains a unique concentration of miRNA, mostly contained in small extracellular vesicles (sEVs) such as exosomes, some of which could be clinically useful for diagnosis and/or prognosis of urogenital diseases[...]

05 Oct

Nanoprobes for the next generation of Optical Imaging

Judit Morlà Folch, CIBER-BBN Researcher in Nanomol Group and NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit at ICMAB-CSIC is giving the seminar “Nanoprobes for the next generation of Optical Imaging“, today Monday, 5 October 2020 at 12 pm, Hosted by Nora Ventosa, Nanomol Group in the cycle of Online ICMAB PostDoc Talk. Online Invited Seminar by Zoom. Register here to attend. About the Seminar: Molecular imaging plays a vital role in the healthcare sector, since abnormal conditions and diseases are often diagnosed through imaging, while therapeutics methods used for the treatment of the abnormalities are often guided by imaging. Optical imaging[...]

02 Oct

New updated version of the CSIC report on COVID-19

The report by Spanish Higher Council for Scientific Research (CSIC) summarizng the most relevant scientific results on the Covid-19 pandemic.  “A global vision of the Covid-19 pandemic: What we know and what we are investigating from CSIC”, has just published its version number 4. This report is structured in five blocks: prevention, disease, containment and diagnosis, treatment and vaccines, and global impact. The containment and diagnosis block describes how the virus is transmitted in the air indoors and the analysis of wastewater as a system for early detection of SARS-CoV-2 is explained. In addition, the importance of diagnosis in t[...]

01 Oct

XIV COURSE OF LAPAROSCOPIC SURGERY OF COLON

CCMIJU has organised the XIV Course of Laparoscopic Surgery of Colon, which wil take place at JUMISC from 14 December to 16 December 2020 under the Direction Francisco Miguel Sánchez Margallo (Deputy Scientific Director of NANBIOSIS) Two of the main lines in the activity of the Minimally Invasive Surgery Centre (CCMIJU) are the Innovation and medical training in collaboration with hospitals and companies of the medical sector, with the aim to improve the quality of healthcare delivered to patients, by providingsurgeons and other health professionals with innovative solutions andtraining. The CCMIJU is part of the Singular Scientific-Technical Facility(ICTS) NANBIOSIS, featuring state-of-the-art technology to beused[...]

30 Sep

NANBIOSIS U12 researchers modify contact lenses to reduce the risk of bacterial infection

Researchers from NANBIOSIS U12 Nanostructured liquid characterization unit, from CIBER-BBN at the IQAC-CSIC have chemically modified contact lenses, incorporating antibacterial properties. Contact lenses, especially soft ones, pose a risk of ocular microbial infection that can eventually lead to loss of vision. “These new contact lenses inhibit the formation of bacterial biofilms and could prevent ocular keratitis” explains Jordi Esquena, a researcher at the CIBER-BBN at the IQAC-CSIC and one of the coordinators of the work. In the study, published in Colloids and Surfaces B: Biointerfaces, bactericidal activity was introduced into hydrogel contact lenses, through antimicrobial peptides that were anchored on[...]

29 Sep

COVID-19 detection system: a fast, cheap and easy to use alternative to PCR.

PCR (acronym in English for “Polymeric Chain Reaction”), is a type of diagnostic test for the detection of infectious diseases. The PCR diagnosis of COVID-19 used since the outbreak of the pandemic offers a high level of specificity and sensitivity but presents a certain degree of complexity, requiring specialized personnel and is expensive. Researchers from Polytechnic University of Valencia (UPV), the Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (FISABIO), the La Fe Health Research Institute (IIS La Fe) and the consortium Centro de Investigación Biomédica en Red de Bioengineering, Biomateriales y Nanomedicina (CIBER-BBN) has[...]

28 Sep

Combination of stem cell therapy and laparoscopy for the treatment of congenital hernia

Researchers of CCMIJU and NANBIOSIS Unit 14 Cell Therapy, led by Javier García Casado, have recently published a study with the purpose to combine stem cell therapy and laparoscopy for the treatment of congenital hernia in a swine animal model proposing an easy and feasible method to combine stem cell therapy and minimally invasive surgical techniques for hernia repair, the first preclinical study evaluating the use of stem cell therapy in the field of abdominal hernias in a clinically relevant swine model with congenital hernia Surgical procedures and imaging diagnoses were performed at the ICTS NANBIOSIS Unit 21 Experimental operating[...]

23 Sep

How Nanophotonic Label-Free Biosensors Can Contribute to Rapid and Massive Diagnostics of Respiratory Virus Infections: COVID-19 Case

An accurate and explanatory review recently published in ACS Sensors. led by Prof. Laura Lechuga, Scientific Director of Nanbiosis U4 Biodeposition and Biodetection Unit from CIBER-BBN and ICN2, discusses current diagnostic techniques for COVID-19 and possible future developments in this field. In particular, after highlighting the advantages and limitations of the methods available at present, the article introduces optical biosensors and illustrates how nanophotonic label-free devices can contribute to meet the emerging needs in this context. For further information at ICN2 website Reference article: Maria Soler, Maria Carmen Estevez, Maria Cardenosa-Rubio, Alejandro Astua, and Laura M. Lechuga, How Nanophotonic Label-Free Biosensors Can Contribute to Rapid and Massive Diagnostics of Respiratory[...]

22 Sep

II Conference on Nanotoxicity. “Dosis sola facit venenum”

NANBIOSIS has participated in the organization of the on-line Conference on Nanotoxicity in collaboration with, CIBER-BBN, Nanomed Spain and Materplat, to debate about the efect of nanotoxicity of nanoparticles and nanotechnologies in health. The session has been started by Ramon Martinez Mañez, Scientific Director of CIBER-BBN and NANBIOSIS U26 NMR: Biomedical Applications II. Isabel Rodriguez (GAIKER Technlogy Center) has taking about tools for risk management of nanomatials differentiating between tools and strategies and explaining their experience in studies carried out. Luis Rojo del Olmo investigador del Grupo de Biomateriales del Instituto de Ciencia y Tecnología de Polímeros del CSIC y del CIBER-BBN) has spoken[...]

21 Sep

NANBIOSIS Expertise in the IQAC-CSIC Symposium dedicated to the fight against Covid-19 Pandemic

The 4th Annual IQAC Symposium will take place on September 23, 2020. This year will be dedicated to the research projects on COVID-19 that are being carried out in the IQAC-CSIC. It will be a dissemination day aiming to inform the general public about some of the lines of research that are currently being developed in the fight against the COVID-19 pandemic. The event will be live streamed in Facebook: facebook.com/iqac.csic.es/ Three of the speakers, members of CIBER-BBN NANBIOSIS units at IQAC-CSIC, will explain their work. Pilar Marco and Roger Galve (NANBIOSIS U2 Custom Antibody Service (CAbS) will talk about[...]

18 Sep

Scientists of Bionand, University of Malaga and CIBER identify a new drug that could mitigate the consequences of COVID infection.

Researchers from Bionand, partner of NANBIOSIS and ​​the University of Malaga toguether with Red de Terapia Celular, CIBER-BBN and CIBER-NED have taken another step in the search for new rapidly implantable therapies to stop the pandemic caused by the coronavirus disease, identifying a new drug that could prevent or mitigate the consequences of the SARS-CoV-2 infection. The team, led by UMA researchers Iván Durán and Fabiana Csukasi, will study over the next year how treatment with 4-Phenylbutyrate (4-PBA) modulates the inflammatory response that occurs in the most severe cases of COVID-19. The first results have already been published in t[...]

17 Sep

New project to alleviate the effects of Covid will be developed by JUMISC, partner of NANBIOSIS

The Jesús Usón Minimally Invasive Surgery Center (JUMISC), partner of NANBIOSIS, will develop an R&D project aimed at alleviating the effects of the health and social crisis of COVID-19, thanks to a collaboration agreement with Banco Santander. The project “Analysis of ligands for SARS-CoV-2 in lymphocyte subpopulations with application for disease staging and patient stratification“, will be developed for a year with the collaboration of researchers from from the San Pedro de Alcántara Hospital in Cáceres, the University of Extremadura, the Reina Sofía Hospital and Mount Sinai in New York. This research initiative aims to provide a reliable prediction of[...]

16 Sep

Maastricht Simulation Award to Konstantinos Mountris and Esther Pueyo

Konstantinos Mountris and Esther Pueyo, (NANBIOSIS Unit 27 High Performance Computing), have been awarded with the Maastricht Simulation Award for their participation in the CinC 2020. Researchers of BSICoS Group, from CIBER-BBN and I3A of Zaragoza University, have participated in the 47 Computing in Cardiology Conference, which took place in Rimini, Italy, during the days 13-16 of September. Alba Martín, was awarded with the Best Remote Poster Presentation for the poster entitled “Model-based characterization of atrial fibrilation episodes and its clinical association“. And the work “Next-generation in-silico Cardiac Electrophysiology through Immersed Grid Meshfree Modelling. Application to Simulation of Myocardial Infarction”[...]

15 Sep

OITBs OPEN CALL TO FIGHT COVID19 – SafeNMT OITB project

JOINT OITBS OPEN CALL TO FIGHT COVID 19 SAFE-N-MEDTECH OITB project in which CIBER-BBN is a partner througth its ICTS NANBIOSIS, gathers expertise from 28 partners around the World focused in enabling the safe translation of nano-enabled medical technologies from Proof of Concept to markets and clinical practice. The sudden COVID-19 outbreak has meant an unforeseen challenge that requires rapid answers from the Science, Technology and Innovation Community. These is a framework where SafeNMT could deploy all its potential: first, because nanotechnology is a Key Enabling Technology that can contribute to innovative approaches to fight COVID 19 and/or other vira[...]

10 Sep

Robust Conditional Independence maps of single-voxel Magnetic Resonance Spectra to elucidate associations between brain tumours and metabolites

Scientists of CIBER-BBN, Ana Paula Candiota and Margarida Juliá managing Nanbiosis ICTS U25 NMR: Biomedical Applications I have participated in the research carried out by Liverpool John Moores University and University of Valencia to elucidate associations between brain tumours and metabolites, published by the journal Plos One. The aim of the paper is two-fold. First, to show that structure finding with the PC algorithm can be inherently unstable and requires further operational constraints in order to consistently obtain models that are faithful to the data. The authors propose a methodology to stabilise the structure finding process, minimising both false positiv[...]

07 Sep

CSIC publishes a report that summarizes the scientific knowledge on Covid-19 and the research projects

The Higher Council for Scientific Research (CSIC) has prepared a report that summarizes the most relevant scientific results on the Covid-19 pandemic. The document compiles results of international research and projects in execution of the 300 research groups of the CSIC Global Health Platform. The report, entitled “A global vision of the Covid-19 pandemic: What we know and what we are investigating from CSIC“, is structured in five blocks: prevention, disease, containment and diagnosis, treatment and vaccines, and global impact. Researchers of NANBIOSIS-ICTS units and CIBER-BBN at CSIC Centres participate in the researches carryed out and in the report. This[...]

24 Aug

Upgrade of UV / Ozone cleaner for NanoeNabler
NANBIOSIS U4 expands its capabilities with a upgrades

NANBIOSIS, U4 Biodeposition and Biodetection Unit has expanded its capabilities with two upgrades: Upgrade of UV / Ozone cleaner for NanoeNabler and Upgrade of the optics and the microfluidic components of the Biodetection Unit (SPR biosensor) This upgrade and new equipment have been confinanced by the European Regional Development Fund (ERDF) through the Plurirregional Operational Program of Spain (POPE)2014-2020[...]

18 Aug

The ATTRACT Online Conference open for registration

The on line Conference ATTRACT – Igniting the Deep Tech Revolution will take pace on 22-23 Sep 2020. The ATTRACT Online Conference website is now live! Please register before 28 August at https://attract-eu-conference.cern.b2match.io/ The ATTRACT Conference offers multiple opportunities to understand the dynamics and contribute to the emergence of a strong European deep tech ecosystem for detection and imaging technologies. The ATTRACT Project is an EC funded initiative led by a consortium of leading European research infrastructures and universities. CIBERBBN and Nanbiosis are involved in MAGRes : Multiparametric MR approaches for non-invasive glioblastoma therapy response follow-up, one of the 170 projects using sensing and imaging technologyto[...]

17 Aug

The University of Zaragoza, in the elite of the 500 best universities in the world

The Academic Ranking of World Universities (ARWU), known as Shanghai Ranking, which was made public on August 15, once again places the University of Zaragoza among the elite of the 500 best universities in the world. This indicator organizes up to 20,000 university centers worldwide. Among the keys that have been able to positively influence the results of the research, according to the Vice Chancellor for Prospect, Sustainability and Infrastructure of the University of Zaragoza, Francisco Serón, are the increase in public campus funding for four years as well as the quality of their Scientists. The University of Zaragoza houses[...]

17 Aug

The Autonomous University of Barcelona, in the elite of the 300 best universities in the world

The Academic Ranking of World Universities (ARWU), known as Shanghai Ranking, which was made public on August 15, places the Autonomous University of Barcelona among the elite of the 300 best universities in the world and the first of the Spanish universities. This indicator organizes up to 20,000 university centers worldwide, based on transparent methodology and objective third-party data. ARWU is regarded as one of the three most influential and widely observed university rankings The Autonomous University of Barcelona houses two of NANBIOSIS Units: U1 Protein Production Platform (PPP), led by Toni Villaverde, Neus Ferrer and Paolo Saccardo, offer an “tailored”[...]

12 Aug

NANBIOSIS U2 expands its capabilities with a two new equpipments

The U2 of NANBIOSIS, Custom Antibody Service (CAbS) has expanded its capabilities with two new equipment items an Automated microdispensing system for microarray technology and a Nitrogen Tank Cryomemo. The Automated microdispensing system for microarray technology is a sciFLEXARRAYER S3 is an automated piezo driven, non-contact dispensing system of ultra-low volumes specifically designed as an economical entry unit for academia and R&D labs. It consists of XYZ-stages with spindle drives, a piezo dispensing unit and precision equipment for liquid handling. The system handles volumes from 50 picoliters up to several microliters. The S3 is suitable for the production  DNA, protein,[...]

10 Aug

The Immunomodulatory Signature of Extracellular Vesicles From Cardiosphere-Derived Cells: A Proteomic and miRNA Profiling

Researcher of CCMIJU published an article in the scientific journal FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY with the participation of NANBIOSIS Unit 14 of Cell Stem CellTherapy where culture and in vitro studies wereperformed, The researchers have shown that the regenerative potential and immunomodulatory capacity of cardiosphere-derived cells (CDCs) is mediated by paracrine mechanisms. In this process, extracellular vesicles derived from CDCs (EV-CDCs) are key mediators of their therapeutic effect. Considering the future applicability of these vesicles in human diseases, an accurate preclinical-to-clinical translation is needed, as well as an exhaustive molecular characterization of animal-derived therapeutic products. Based on that,[...]

31 Jul

A Study of Fluid Dynamics and Chemical Parameters

Researchers of NANBIOSIS -ICTS U9, Synthesis of Nanoparticles Unit, from CIBER-BBN andAragon Institute of Nanoscience (INA), have published an interesting study on the Scientific Jounal Materials of Fluid Dynamics  and  Chemical Parameters. The objective of the the work was to produce gastroresistant Eudragit (R) RS100 nanoparticles by a reproducible synthesis approach that ensured mono-disperse nanoparticles under the size of 100 nm. Batch and micromixing nanoprecipitation approaches were selected to produce the demanded nanoparticles, identifying the critical parameters affecting the synthesis process. To shed some light on the formulation of the targeted nanoparticles, the effects of particle size and homogeneity of fluid dynamics,[...]

26 Jul

Innovation Radar “Great EU-funded Innovations”

The Innovation Radar Platform is a European Commission initiative to identify high potential innovations and innovators in EU-funded research and innovation framework programmes based on their market readiness. Researchers of NANBIOSIS U8 Micro– Nano Technology Unit, led by Rosa Villa, contribute to the @InnoRadarEU with two innovations related to their research on graphene-based neuroprobes: Flexible neural probes for monitoring infraslow brain activity This innovation was developed under the Horizon 2020 project GrapheneCore2 by CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED (CIBER), FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA (ICN2) and AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS (CSIC) Multiplexed Neurosensor Arrays based[...]

23 Jul

II Conference on Nanotoxicity, organised by Nanomed Spain, NANBIOSIS and Materplat, Sept. 22

NANBIOSIS is organizing an on-line Conference on Nanotoxicity in collaboration with Nanomed Spain and Materplat, next September 22, to debate about the efect of nanotoxicity of nanoparticles and nanotechnologies in health. Nanotechnology, a science involved in the design, production, and use of structures and objects that have at least one of their dimensions on the scale of 100 nanometers or less, is enabling progress to be made in various areas with far-reaching repercussions. scope for society. Currently, there are several areas in which nanotechnology is under development or even in the practical application phase. However, manufactured nanoparticles can have very different properties and effects[...]

23 Jul

Workshops on Robotic Surgery with experimental models at CCMIJU

This year, CCMIJU, partner of NANBIOSIS, at Cáceres, has organised some new hands-on and customised workshops with robotic technology, expected for 2020 last term. Specifically CCMIJU is organising, in collaboration with the Enterprise ABEX-Excelencia Robótica SL, some workshops on Robotic Surgery (da Vinci Xi) using experimental models. They are addressed to health professionals from several specialties (urology, gynaecology, general surgery and thoracic surgery) interested in practising with this technology. The workshops will count on a clinical specialist from ABEX, who will explain the technical features of the robotic equipment, the associated technologies and the virtual simulator for exercises. Subsequently the health professionals,[...]

22 Jul

The Scientific Director of NANBIOSIS Unit 7, awarded with the Narcís Monturiol medal for his contribution to science and technology

The Catalan Government announced yesterday the Narcís Monturiol Medal award for scientific and technological merit to the Director of NANBIOSIS Unit 7 Nanotechnology Unit from CIBER-BBN and IBEC, Josep Samitier Martí, for his contribution to the development of the Catalan system of science and technology. The Narcís Monturiol Prize was established by the Generalitat of Catalonia in 1982, in honor of the Catalan scientist and inventor Narciso Monturiol, to award the people and entities that have made an outstanding contribution to the scientific and technological progress of Catalonia. It is awarded in the form of medals and plaques. The medals[...]

16 Jul

Unlocking the brain with novel graphene technology

Researchers of NANBIOSIS U8 Micro– Nano Technology Unit of CIBER-BBN at the Barcelona Institute of Microelectronics have participated in the recent developments of a new graphene-based detection platform that could be the gateway to unlock superior understanding of the brain by providing a measure of high brain activity resolution and in real time. This research has been developed within the framework of the EU BrainCom project. The European Union’s Horizon 2020 research project, BrainCom, is coordinated by the ICN2 Advanced Electronic Materials and Devices Group led by Professor José A. Garrido and the CIBER BBN GBIO Group and the Nanbiosis[...]

15 Jul

Biocidal releasing dressings of natural origin to treat topical wounds and avoid antibiotic resistance

Researchers of NANBIOSIS U9 Synthesis of Nanoparticles Unit, of the CIBER-BBN at the University of Zaragoza, use thymol as a natural biocide, a component present in the essential oils of thyme and oregano, thus fighting against the predictions that in 2050 there will be more deaths from infections associated with antibiotic-resistant bacteria than from cancer. Some topical wounds caused by burns, by surgical procedures, diabetic foot ulcers, fistulas, pressure ulcers, etc. they can become infected and become chronic, rendering current treatments ineffective. Currently, the devitalized tissue is removed, the area is cleaned, it is drained and depending on the microbia[...]

13 Jul

Cardiac hypertrophy research with NANBIOSIS unit 17 Confocal Microscopy Service participation

A new article has been recently published about Cardiac hypertrophy research in the Scientific Reports Jorunal by NatureResarch, counting with the expertise of NANBIOSIS unit 17 Confocal Microscopy Service form CIBER-BBN and University of Alcalá de Henares. Cardiac hypertrophy is the abnormal enlargement, or thickening, of the heart muscle, resulting from increases in cardiomyocyte size and changes in other heart muscle components, such as extracellular matrix. This article relates more especifically with the link between long term exposure to xenoestrogen Bisphenol-A and adverse cardiovascular effects and the role of necroptosis in cardiac response to BPA had not yet been explored.[...]

09 Jul

A new nanoconjugate blocks acute myeloid leukemia tumor cells without harming healthy ones

Researchers from NANBIOSIS U18 Nanotoxicology Unit at the Institut d’Investigació Biomèdica de Sant Pau (IIB Sant Pau) and NANBIOSIS U1 Protein Production Platform (PPP) at the Universitat Autònoma de Barcelona (UAB) toghether with researchers of Institut de Recerca contra la Leucèmia Josep Carreras (IJC) have demonstrated the efficacy of a new nanoconjugate, designed in house, that blocks dissemination of leukemic cells in animal models of acute myeloid leukemia. These results have been published in a high impact scientific journal in the field of oncology and hematology, Journal of Hematology and Oncology. Most of the experimental work has been performed in[...]

03 Jul

From natural by-products to cell delivery systems for regenerative medicine

Researchers from NANBIOSIS U10 Drug Formulation unit (CIBERBBN – UPV/EHU led Rosa María Hernández, have developed a biomedical device consisting of by-products from the food industry and which displays excellent properties for use in regenerative medicine. The work has been published in the Green Chemistry Jurnal, one of the most prestigious international journals in chemistry and the second most important one in the field of sustainable science. The work has also been selected for the cover page of this issue. Researchers in the UPV/EHU’s NanoBioCel and Biomat groups have developed a biomedical device consisting of by-products from the food industry and which displays excellent[...]

29 Jun

II Course on introcuction to research and laboratory techniques in biomedicine

JUMISC has organised the Course on introcuction to research and laboratory techniques in biomedicine which wil take place during the month of July, co-Directed by Francisco M. Sanchez Margallo, Deputy Scientific Director of NANBIOSIS  and Javier García Casado, Scientific Director of NANBIOSIS unit 14 Cell Therapy. Further information and programe: here Inscriptions: her[...]

25 Jun

Manuel Doblaré, researcher of NANBIOSIS U13, new Chairman of IMDEA Materials Foundation

Manuel Doblaré researcher of the Group Applied Mechanics and Bioengineering – AMB and NANBIOSIS U13 Tissue & Scaffold Characterization Unit of CIBER-BBN and I3A presides, from this month, the Board of Trustees of the Imdea Materiales Foundation. The IMDEA Materials Institute, one of the seven Madrid Institutes for Advanced Studies (IMDEA), is a public research centre founded in 2007 by Madrid’s regional government. The goal of the Institute is to do research at the forefront of Material Science and Engineering, attracting talent from all around the globe, and collaborating with companies in an effort to transfer fundamental and applied knowledge into[...]

25 Jun

NANBIOSIS scientists in Aragón, explain on TV their research againts coronavirus

The special program on the coronavirus pandemic  by “En Ruta con la Ciencia” of Aragón Televisión, analyzes different aspects of the disease with special attention to the work of Aragonese scientists. Among them, two  research groups that coordinate NANBIOSIS units 9 and 27. Starting at minute 44’45 ‘of the program, Doctor Jesús Lázaro, researcher of the BSICoS group of I3A-UZ and CIBER-BBN, led by Pablo Laguna, which coordinates NANBIOSIS U27 High Performance Computing Unit, explains his research. For almost 3 years, Jesús Lázaro had been working on a European project to develop a respiratory and heart rate monitoring system for[...]

23 Jun

Optimization of Recycled-Membrane Biofilm Reactor as a sustainable biological treatment for microcystins removal with nanbiosis expertise.

Jesús Morón-López (IMDEA), Serena Molina (Chemical Engineering Department, University of Alcalá) have recently published the results of their research about Recycled-Membrane Biofilm Reactor as a sustainable biological treatment for microcystins (MC) removal. The study addresses the lack of sustainable technologies for water treatment, while opening an alternative in sustainable solid waste management under a circular economy approach. The biofilm visualization has been performed by ICTS “NANBIOSIS”, more specifically by the Unit 17 Confocal Microscopy Service of Ciber in Bioengineering, Biomaterials & Nanomedicine (CIBER-BNN) at the Alcala University (CAI Medicine Biology) led by Juan Manuel Bellón y Gemma Pascual. In this[...]

21 Jun

The European Commission releases a video showing the European project against coronavirus led by prof Laura Lechuga

The European Commission Representation in Barcelona has published the five-minute video “The EU fights the Covid-19 from Catalonia” in which four researchers explain the projects they are working on. The researchers appearing in the video are  Laura Lechuga Scientific Director of NANBIOSIS unit 4 from CIBER-BBN and ICN2-CSIC and Group Leader of CIBER-BBN at the ICN2 Nanobiosensors and Bioanalytical Applications Group), who works on a sensor to detect the coronavirus in a faster, easier and cheaper way than with current PCRs, Núria Montserrat (IBEC), who works on micro-kidneys made from stem cells to test a drug able to block the virus, Alfonso Valencia (BSC), who explains[...]

17 Jun

Hydrogels structured with dual stimuli responsive for biomedical applications

Researchers of NANBIOSIS Unit 17 Confocal Microscopy Service have participated in the research carried out structuring hydrophobic domains in Poly(N-isopropylacrylamide-co-Methacrylic acid) hydrogels for biomedical aplplications. Hydrogels are cross-linked polymeric networks, which have the ability to hold a large amount of water in their structure. Hydrogels can be designed to respond to a specific stimulus such as temperature, pH, ionic strength, light, etc., making making them suitable for biomedical applications, as drug delivery. The most popular responsive polymeric hydrogel is made of poly(N-isopropylacrylamide) (PNIPAM). The copolymerization of NIPAM with an acrylic/methacrylic acid monomer permits the development of a hydrogel with a[...]

12 Jun

Seminar on Molecular probes and gated materials in biomedical applications by Ramón Martínez, now in youtube

Last June 8, 2020,  Ramón Martínez Máñez, Scientific Director of CIBER-BBN and NANBIOSIS U26, gave an on line seminar, hosted by Jaume Veciana and Anna Roig will from ICMAB-CSIC on Molecular probes and gated materials in biomedical applications and communication between nanoparticles. If you missed the seminar, you can see it now on YouTube: More information at the ICMAB website.[...]

08 Jun

NANBIOSIS researchers featured in the 15th Edition of Spanish Researchers Ranking

The 15th edition of the Webometrics Ranking of World Universities has been published, ranking researchers in Spain as well as Spaniards doing research abroad. A total of 11 Directors of NANBIOSIS units appear on the most recent list, featured on the top 2000. The list is ordered by the h-index, a metric that calculates research impact based on a correlation of papers published and number of citations, and then by number of citations. The result is a list of whose’s publications have had more impact online. NANBIOSIS researchers featured are Fernando Albericio (#207), scientific director of U3 Synthesis of Peptides[...]

04 Jun

Open call for contribution to the Special Issue by MDPI in IJMS about “In Vivo Biomarkers for Immunotherapy Efficacy in Brain Tumours”

Ana Paula Candiota, Scientific Coordinator of NANBIOSIS U25 NMR: Biomedical Applications I Unit (from CIBER-BBN and Autonomous University of Barcelona), is the Guest Editor of a special issue launched by MDPI in the International Journal of Molecular Sciences (IF 4.183). This special issue is about “In Vivo Biomarkers for Immunotherapy Efficacy in Brain Tumours” Contributions with papers or reviews to this issue, can be fowarded to the Guest Editor (AnaPaula.Candiota@uab.cat) with a tentative title and/or abstract. Final deadline for submission: 31/10/2020[...]

03 Jun

Expoquimia hosts the INDUSTRIAL DIALOGUES Webinars with Nora Ventosa

The International Meeting for Chemistry Expoquimia is hosting the INDUSTRIAL DIALOGUES Webinars, a total of 4 seminars discussing different topics related to the cores of the triennial meeting: circular economy, digitalization, and technology transference. This last topic will be covered by Nora Ventosa, Scientific Coordinator of NANBIOIS Unit 6Biomaterial Processing and Nanostructuring Unit On 4 June, Nora Ventosa, Nora Ventosa will be moderating the round table on the topic of technology transference both as a researcher of the Nanomol group, from CIBER-BBN and ICMAB-CSIC, and as part of the Expoquimia Organizing Comitée. The discussion will be focused on the topic “Creating tools to make innovation a reality. Science and[...]

02 Jun

Automatic Detection of Slow Conducting Channels during Substrate Ablation of Scar-Related Ventricular Arrhythmias

Researchers of BSICoS Group form CIBER-BBN and I3A-Unizar, coordinating NANBIOSIS Unit 27 tooghether with researchers of Physense group of UPF and Hospital Clinic have carried out the research which results have been just published by Journal of Interventional Cardiology. The researchers propose automatic analysis of EGM signals using the “Slow Conducting Channel Mapping Algorithm” that improves the accuracy of bipolar voltage measurements within the scar area, achieving a more detailed tissue characterization and being an operator-independent tool for accurate identification of SCCs. This last feature encourages the use of the algorithm together with EAM navigation systems as a reproducible approac[...]

01 Jun

New methods to detect Coronavirus: interactive webinar on the diagnosis of COVID-19

CSIC has orgnized an interactive webinar on new COVID-19 detection systems that brings together biotechnologist Luis Blanco, nanotechnologists Laura Lechuga and Pilar Marco, and physicist Javier Tamayo . Researchers from the Higher Council for Scientific Research (CSIC) will answer citizens’ questions about the diagnostic methods of the SARS-CoV-2 coronavirus, which causes Covid-19, in a webinar or interactive debate that will be broadcast on Wednesday, June 3, at 8:15 p.m., on the CSIC YouTube channel. The meeting will feature the participation of biotechnologist Luis Blanco, the physicist Javier Tamayo and the nanotechnologists Laura Lechuga, Scientific Director of NANBIOSIS unti 4 Biodeposition[...]

28 May

New fluorescent organic nanoparticles to see the invisible

A new nanomaterial for bioimaging has been developed by researchers at NANBIOSIS Unit 6 Biomaterial Processing and Nanostructuring Unit from the Nanomol group from ICMAB-CSIC and CIBER-BBN . The researchars are also members of the TECNIO technology transfer network ACCIÓ-Generalitat de Catalunya, together with the New Jersey Institute of Technology (NJIT, USA) and the University of Parma (UNIPR, Italy). The results of the study are the result of the TECNIOspring PLUS project co-financed by ACCIÓ and the European Commission. It is true that it is very difficult to understand what happens in our bodies if we are unable to visualise it. For example, we currently know that tumour cells[...]

27 May

Peptide‐Capped Mesoporous Nanoparticles: Toward a more Efficient Internalization of Alendronate.

Osteoporosis is an illness which appears when the osteoblast/osteoclast activities are unbalanced taking place bone resorption (caused by osteoclasts) in higher extension than bone formation (induced by osteoblasts). Alendronate is one of the most used drugs for osteoporosis treatment despite its scarce bioavailability. In an attempt to improve it, gated mesoporous silica nanoparticles, for the controlled release of alendronate, have been synthesized and characterized. These hybrid nanoparticles include labelled alendronate inside the porous, those porous are capped with a peptide designed to be selectively cleaved by cathepsin K enzyme (overexpressed in osteoclasts). Two CIBER-BBN units of the ICTS NANBIOSIS wer[...]

25 May

A recombinant SARS-CoV-2 vaccine

NANBIOSIS Protein Production Platform (PPP) Unit 1 (of CIBER-BBN and Autonomous University of Barcelona) is involved in a micro-patronage project for the development of a vaccine for COVID 19. NANBIOSIS Unit 1 is directly involved in the initial part of the Virus Like Particles and Proteins expression and purification project of SARS-COV-2 Most vaccines used today are based on either attenuated forms of the original pathogen, or are inactivated vaccines, in which the pathogen has undergone physical or chemical treatments to eliminate its infectivity. The project proposes to use a new vaccine strategy based on recombinant proteins in imitation of[...]

25 May

A project to develop rapid and early diagnostic tests of Covid-19 to reduce false negatives

The Journal Heraldo de Aragón has published an article highlighting the participation of Aragonese researchers in projects to fight Covid-19 Pandemic. Pilar Martín Duque, researcher from NANBIOSIS U9 Synthesis of Nanoparticles Unit, is leading a project financed by the Covid-19 Fund, launched by the Carlos III Health Institute (ISCIII). Thanks to this project, rapid and early diagnostic tests of Covid-19 are being developed to reduce false negatives. To read the article: https://www.heraldo.es/branded/la-tecnologia-y-la-innovacion-claves-vitales-para-el-desarrollo-sostenible/[...]

25 May

“We need a drastic change in the organization and management of science”

The Jorunal “Redacción Médica” has created an espace call Covid-19 Lessons to gather critical evaluations and recommendations of the most relevant personalities in the health sector, so that the National Health System and the professional and business ecosystem that surrounds it can draw conclusions and face future similar challenges with greater guarantees. Laura M. Lechuga, Scientific Director of NANBIOSIS U4, from CIBER-BBN at ICN2-CSIC, coordinates CONVAT, one of the projects selected by the European Commission to advance in the knowledge about the Coronavirus, adds her perspective to the document Covid-19 Lessons: “We need a drastic change in the organization and[...]

23 May

New therapy for triple negative breast cancer is successfully tested in preclinical animals

Researchers CIBER-BBN and NANBIOSIS Unit 26, the Príncipe Felipe Research Center (CIPF), the Universitat Politècnica de València (UPV) and the Institut de Recerca Biomèdica (IRB) of Barcelona manage to inhibit tumor growth, reduce metastasis and decrease the toxicity of the antitumor drug Navitoclax in preclinical animal models of triple negative breast cancer (TNBC). These types of TNBC tumors do not express any of the three receptors involved in most breast cancers (estrogen, progesterone, and HER2), so the most common treatments such as hormone therapy are not viable in these patients. This new study, led by Mar Orzáez, principal investigator of[...]

22 May

Scientific trends with the participation of NANBIOSIS expertise

Within the series of virtual conferences organized during the months of May, June and July by the Extremaduran office, two researchers of NANBIOSIS are invited speakers: Laura M. Lechuga Gómez, NANBIOSIS Unit 4 Biodeposition and Biodetection Unit (form CIBER-BBN and ICN2-CSIC); and María Coronada Fernández Calderón NANBIOSIS U16 Surface Characterization and Calorimetry Unit (from CIBER-BBN and University of Extremadura)who will talk about technologies at the service of health. The cycle ’90 minutes for Science, for innovation to bring society closer to the latest scientific trends, starts next Wednesday, May 27, at 5:00 p.m. It will deal with topics such as[...]

20 May

NAV-GAL, a new senolytic drug against cancer, on spanish TV

The work carried out by the team of researchers of CIBER-BBN and Politecnic University of Valencia, led by, Ramón Martínez Máñez, Scientific Director of NANBIOSIS U26 NMR: Biomedical Applications II, is highlighted by the Spanish TV. This team has developed a new drug against lung cancer that, along with other therapies, eliminates cells that have been bottled prematurely without harming healthy ones. The drug has been successfully administered in mice, now it comes the challenge of finding a way to administer it without damaging the patient’s healthy organs, and they propose inserting it into a capsule that would be released[...]

17 May

“Molecular probes and gated materials in biomedical applications and communication between nanoparticles” by Ramón Martínez

Next June 8, 2020, 12 pm, Ramón Martínez Máñez, Scientific Director of CIBER-BBN and NANBIOSIS U26, give an on line seminar, hosted by Jaume Veciana and Anna Roig will from ICMAB-CSIC. The development of optical molecular probes and probes based on gated nanoparticles has been an area of interest during the last decades. Optical probes are able to transform chemical information in the environment into a suitable optical signal, usually a change in colour of fluorescence. Moreover, gated materials have also been widely used for the development of drug delivery systems. Some examples of optical probes and gated materials for[...]

15 May

CoNVaT, the ‘Nanotrap’ for the coronavirus – highlighted by BBVA Fundation

Prof. Laura M. Lechuga, Scientific Director of NANBIOSIS Unit 4 Biodeposition and Biodetection Unit (from CIBER-BBN and ICN2-CSCIC) was awarded with the Physics, Innovation and Technology Award of the Royal Spanish Physics Society (RSEF) and the BBVA Foundation 2016. BBVA Foundation has dedicated an article to explain the  EU CoNVaT project, led by Laura Lechuga, whose objective is to obtain a diagnostic test for COVID-19 from the first day of infection, fast but highly sensitive, and which does not require a laboratory or qualified personnel. A test made with extremely sophisticated technology, and at the same time low cost, applicable to[...]

11 May

NANBIOSIS Scientists discover a promising effective alternative to reduse relapse rates in Diffuse Large B-cell Lymphoma Cells

Researchers of NANBIOSIS-ICTS Units from CIBER-BBN: U1 Protein Production Platform (PPP) at IBB-UAB, led by Antoni Villaverde and Unit 18 Nanotoxicology Unit at IBB-Hospital Sant Pau, led by Ramón Mangues, have demonstrated a potent T22-PE24-H6 antineoplastic effect, especially in blocking dissemination in a CXCR4+ DLBCL model without associated toxicity. Thereby, T22-PE24-H6 promises to become an effective alternative to treat CXCR4+ disseminated refractory or relapsed DLBCL patients. Diffuse large B-cell lymphoma (DLBCL) is a cancer of B cells, a type of lymphocyte that is responsible for producing antibodies. It is the most common form of non-Hodgkin lymphoma among adults, with an annual incidence of 7–8 cases per 100,000 people per year in the US and[...]

10 May

Neurocardiac Oscillation in Repolarization and Cardiac Arrhythmias

David Sampedro and Esther Pueyo, from NANBIOSIS Unit 27 High Performance Computing (CIBER-BBN, I3A-UZ) have conducted a research about Neurocardiac Oscillation in Repolarization and Cardiac Arrhythmias. Recent studies in humans and dogs have shown that ventricular repolarization exhibits a low-frequency (LF) oscillatory pattern following enhanced sympathetic activity, which has been related to arrhythmic risk. The appearance of LF oscillations in ventricular repolarization is, however, not immediate, but it may take up to some minutes. This study seeks to characterize the time course of the action potential (AP) duration (APD) oscillatory behavior in response to sympathetic provocations, unveil its underlying mechanisms[...]

08 May

Prof. Laura Lechuga is part of the experts advising the government on the COVID-19 crisis

The Fourth Vice-President of the Government and Minister for the Ecological Transition and the Demographic Challenge, Teresa Ribera, and the Minister of Science and Innovation, Pedro Duque, met with the Multidisciplinary Working Group that advises and supports the Ministry of Science and Innovation in scientific matters related to the COVID-19 and its future consequences. It also coordinates the preparation of reports and will propose the necessary modifications to improve the response to similar crises in the future. The group is formed by 16 experts in fields such as law, economy, biochemistry, bioinformatics, artificial intelligence, physics, statistics, immunology or medicine. Prof. Laura Lechuga, Scientific[...]

06 May

JUMISC will carry out PCR test for COVID-19 infections

The Institute of Health Carlos III (ISCIII), depending of the the Ministry of Science and Innovation, has validated thirty new centers for carrying out PCR tests for COVID-19 infections throughout Spain. The Minimally Invasive Surgery Center, together with the University of Extremadura (JUMISC), partner of NANBIOSIS, will carry out these PCR tests in the laboratory of the veterinary faculty of Cáceres, as it is a P2 biosafety laboratory that is already approved. They will have the capacity to perform 200 daily PCRs and will work with the samples that the the Extremadura Health Service will send them. In total, Spain[...]

05 May

A new compound removes senescent cells and reduces toxicity in cancer treatment

Scientists of NANBIOSIS unit 26 NMR: Biomedical Applications II, (of CIBER-BBN and the Universitat Politècnica de València), together with researchers from the Principe Felipe Research Center and the University of Cambridge confirm the therapeutic potential of using a new conjugated drug, Nav-Gal, in combination with chemotherapy Nav-Gal selectively removes tumourigenic senescent cells without attacking healthy cells and reduces the toxicity of platelets The accumulation of senescent cells plays a significant role in cancer pathogenesis and other diseases. However, senolytic drugs (intended to remove senescent cells) present significant toxicity, which limits their therapeutic benefits. Now, a new international study involving researchers[...]

03 May

Pilar Marco explains on TV her group’s research against Covid-19 pandemic

M.-Pilar Marco, Scientific Director of NANBIOSIS Unit 2 Custom Antibody Service (CAbS) has been interviewed on Spanish TV (RTVE) to talk about her research against the Covid-19 pandemic in the frame of the CSIC POC4CoV project, for the development of new and rapid diagnostic tools. Nb4D group of CIBER-BBN and IQAC-CSIC, led by Prof. Marco is working on the development of tests to increase the efficiency and speed of diagnosis of the methods currently on the market. According to Pilar Marco, the new strategy of the project differs basically in two fundamental aspects: on the one hand the technology, whic[...]

30 Apr

Scientists from NANBIOSIS selected by Barcelona Activa “Preacceleration” Program

Nora Ventosa and Nathaly Segovia, (Scientific Director and Coordinator of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit from CIBER-BBN and ICMAB_CSIC), have been selected as part of the NARTIC Project team for an incubation program by Barcelona Activa. NARTIC is a biotech project for the development of molecular therapy based on Quatsomes for diseases such as cancer. The NARTIC project has recently been selected for the 6th edition of the Preacceleration Program, an incubation program developed by Barcelona Activa for starting ventures with a high technological impact. The project team includes two researchers from the Molecular Nanoscience and Organic Materials (NANOMOL) group (from CIBER-BBN and ICMAB-CSIC): Nora Ventosa, as scientific advisor, and Nathaly Segovia, as[...]

28 Apr

Microencapsulated Insulin-Like Growth Factor-1 therapy improves cardiac function and reduces fibrosis in a porcine acute myocardial infarction model

Researchers of NANBIOSIS Units at JUMISC. led by Verónica Crisóstomo, Scientific Director of NANBIOSIS unit 24 of Medical Imaging, have just published an article in the Journal Scientific Report Cardiovascular diseases, especially ischemic heart disease, are the leading cause of mortality worldwide. Conventional treatments have contributed to reduce early mortality after an acute myocardial infarction, but do not recover the damaged myocardial tissue. In the last two decades stem cell therapy has been studied for that purpose. Nowadays it is known now that stem cells are able to secrete combinations of biomolecules that modulate the composition of the damaged cardiac[...]

26 Apr

A Concise Review on Nano-emulsion Formation by the Phase Inversion Composition (PIC) Method

Researchers of NANBIOSIS U12. Nanostructured liquid characterization unit from CIBER-BBN and IQAC-CSIC have recently published an interesting review entitled “A Concise Review on Nano-emulsion Formation by the Phase Inversion Composition (PIC) Method” in the JOURNAL OF SURFACTANTS AND DETERGENTS. https://doi.org/10.1002/jsde.12414 Studies of phase behavior and particle sizing were performed at the Nanostructured Liquid Characterization Unit, member of the NANBIOSIS ICTS.[...]

23 Apr

NANBIOSIS U27 researchers working in an App for the early diagnosis of covid-19 through mobile phones

Bsicos group researchers, from the I3A (Engineering Research Institute) of the University of Zaragoza and CIBER-BBN), Dr. Jesús Lázaro, Dr. Eduardo Gil, Dr. Raquel Bailón and Dr. Pablo Laguna, are working on a line of work for the search of solutions for the early diagnosis of Covid-19 cases, through the development of an App for mobile phones. For almost three years, Dr. Jesús Lázaro, under the supervision of Professor Pablo Laguna, from the resarch group Bsicos, which coordinate Nanbiosis U27 High Performance Computing , have been working on the European project WECARMON (Wearable Cardiorespiratory Monitor) for the development of an[...]

22 Apr

Wearable Armband Device for Daily Life Electrocardiogram Monitoring

Researchers Dr. Jesús Lázaro and Dr. Pablo Laguna, from Bsicos group, which coordinate Nanbiosis U27 High Performance Computing from I3A -Engineering Research Institute of the University of Zaragoza- and CIBER-BBN, in the framework of the European project WECARMON (Wearable Cardiorespiratory Monitor) are coauthors of the recently published article titeled “Wearable Armband Device for Daily Life Electrocardiogram Monitoring” in the Scientific Journal IEEE Transactions on Biomedical Engineering ( Early Access ) “Our long-term wearable armband is evaluated as heart rate monitor with 24h recordings during daily life”, explained Dr. Jesús Lázaro. A wearable armband electrocardiogram (ECG) monitor has been used for daily life monitoring. T[...]