Singular

Modification of oligonucleotides during and post synthesis to meet user requirements:

• Conjugation of oligonucleotides with fluorophores (fluoresceine, Cy3, Ct5, etc..) and other types of small molecules such as biotine, lipids.
• Conjugation to peptides.
• Phosphorothioate linkages
• Modified backbones such as locked nucleic acids (LNA), 2’-O-alkyl-RNA, etc..
• Modified nucleobases: 2-aminopurine, 5-methyl-dC, etc…
• 5’, 3’-modifications such as 5’-, 3’-amino, 5’-, 3’-thiol, etc..

Synthesis of oligonucleotides at various different scales (100 microg to 5 mg) and purification using HPLC and/or desalting.