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Singular

Singular

U16-S07. Evaluation of the adhesion capacities and formation of biolayers of microorganisms on materials. Evaluation of bactericidal and/or bacteriostatic responses of materials. OUTSTANDING

Description:

Evaluation of the adhesion of microorganisms to surfaces, including the evaluation of their viability. Adhesion can be studied under flow or static and at different contact times. Study of biolayers formed on materials after different growth times. Evaluation of bactericidal and/or bacteriostatic responses using viability kits or plate growth.


Applications:

Testing of materials with anti-infective objectives. Testing of compounds with antibacterial purpose.

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U16-S06. Topographic characterization service using optical profilometry OUTSTANDING

This service makes it possible to determine the surface tension of both solids and liquids under controlled temperature and humidity conditions, even locally by means of deposited drops with a volume of around 10-12 L. The service will be provided by specialists in the characterization of materials in dimensions macroscopic or in colloidal systems. The service can meet the needs of business R&D&i, providing support for their controls according to ISO, ASTM, ASME and EUR standards. In addition, it can also serve research groups with detailed reports according to the needs of the study.

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U16-S05. Characterization service by contact angle goniometry OUTSTANDING

This service makes it possible to determine the surface tension of both solids and liquids under controlled temperature and humidity conditions, even locally by means of deposited drops with a volume of around 10-12 L. The service will be provided by specialists in the characterization of materials in dimensions macroscopic or in colloidal systems. The service can meet the needs of business R&D&i, providing support for their controls according to ISO, ASTM, ASME and EUR standards. In addition, it can also serve research groups with detailed reports according to the needs of the study.

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U13-S09. COMPRESSION-SHEAR TEST CELLSCALE MicroTester G2 (On-site) OUTSTANDING

U13-S09. COMPRESSION-SHEAR TEST CELLSCALE MicroTester G2 (On-site) OUTSTANDING

Uniaxial tensile and shear tests

Description: By detecting small changes in a force sensing micro-wire, the system can measure forces and displacements that are much smaller than a conventional mechanical test system. The system incorporates a temperature-controlled fluid bath for maintaining ideal specimen conditions and a high-quality optical system to provide user feedback

Aplications: Tension and compression and shear test of hydrogel microspheres, cell spheroids, and engineered microtissues

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U8-S05.

Deposition of thin films (Polyimide, Parylene) for the fabrication of flexible devices or encapsulation purposes (On-site&Remote) OUTSTANDING.

Deposition of Polyimide (PI-2611) via spin-coating for the fabrication of flexible free-standing structures.
Conformal deposition of Parylene (different types available)

Customer benefits

  • Possibility to access to the PI deposition system in self-service mode to adapt the process to the customer needs.
  • Different Parylene types available for deposition to match customer needs

Target customer

Research groups and SMEs

References

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U8-S06.

Encapsulation or fabrication of 3D strcutures via 3D printing.

Fabrication of 3D structures using a dual extrusion 3D printer that delivers high-quality, composite-ready performance – in a smaller footprint

Customer benefits

Possibility to access to the 3D printing equipment in self-service mode to adapt the process to the customer needs.

Target customer

Research groups and SMEs

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U20-S015. Cytotoxicity: proliferation, LDH, apoptosis and ROS

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U20-S014. Hemocompatibility: hemolysis, platelet aggregation, plasma coagulation times and complement activation

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U20-S013. Detection of microbial (bacterial and mycoplasma) contaminationpre

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U29-S03. Special nucleotides for oligonucleotide synthesis. (Remote) OUTSTANDING

Special nucleotides for oligonucleotide synthesis

This service is dedicated to the custom synthesis of modified nucleotides such as nucleoside monophosphates or triphosphates as well as special phosphoramidites or functionalized solid supports functionalized with small molecules resistant to ammonia deprotection for the preparation of oligonucleotide conjugates.

Special nucleotides for oligonucleotide synthesis

For those services identified as outstanding, at least 20% of their capacity is open under competitive access. See Annex 1 of ACCESS PROTOCOL (provided by Nanbiosis) for details on % of openness for each service

Customer benefits

The service benefits from the 40-years’ experience of the researchers participating in the service with hundreds of scientific communications on improving the methodology used for the synthesis of modified oligonucleotides. This includes a range of modified nucleotides and terminal modifications not available in other services. In addition, the service can develop customized solutions for molecules not covered in the bibliography.

Target customer

The primary audience are research groups and companies involved in gene therapy, gene silencing and the development of nucleic acid-based diagnostic tools.

References

1) “Oligonucleotides containing 1’-aminomethyl or 1’-mercaptomethyl-2’-deoxy-D-ribofuranoses: Synthesis, purification, characterization and conjugation with fluorophores and lipids”. Martín-Nieves, V. et al. Bioconjugate Chem, 32, 350-366 (2021).
2) “Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy”. Aviñó, A. et al. Chemistry Open, 8, 382-387 (2019).
3) “Thioctic acid derivatives as building blocks to incorporate DNA oligonucleotides onto gold nanoparticles”. Pérez-Rentero, S. et al. Molecules, 19, 10495-10523 (2014).

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