U29-S02. Modification of oligonucleotides. (Remote) OUTSTANDING
Modification of oligonucleotides during and post synthesis to meet user requirements:
- Conjugation of oligonucleotides with fluorophores (fluoresceine, Cy3, Ct5, etc..) and other types of small molecules such as biotine, lipids.
- Conjugation to peptides.
- Phosphorothioate linkages
- Modified backbones such as locked nucleic acids (LNA), 2’-O-alkyl-RNA, etc..
- Modified nucleobases: 2-aminopurine, 5-methyl-dC, etc…
- 5’, 3’-modifications such as 5’-, 3’-amino, 5’-, 3’-thiol, etc..