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Modification of oligonucleotides during and post synthesis to meet user requirements:
Special nucleotides for oligonucleotide synthesis For those services identified as outstanding, at least 20% of their capacity is open under competitive access. See Annex 1 of ACCESS PROTOCOL (provided by Nanbiosis) for details on % of openness for each service
Synthesis of oligonucleotides at various different scales (100 microg to 5 mg) and purification using HPLC and/or desalting.
Preclinical regulatory in vivo toxicity, local and systemic tolerance and PK/PD studies; dosing of test and specimen drawing, biocompatibility studies of medical devices; Safety studies: Nervous, cardiovascular and respiratory systems.
Security testing of advanced therapies using small and large animals models.
Characterization and development of pulmonar formulations