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Singular

Singular

U29-S02. Modification of oligonucleotides. (Remote) OUTSTANDING

Modification of oligonucleotides during and post synthesis to meet user requirements:

  • Conjugation of oligonucleotides with fluorophores (fluoresceine, Cy3, Ct5, etc..) and other types of small molecules such as biotine, lipids.
  • Conjugation to peptides.
  • Phosphorothioate linkages
  • Modified backbones such as locked nucleic acids (LNA), 2’-O-alkyl-RNA, etc..
  • Modified nucleobases: 2-aminopurine, 5-methyl-dC, etc…
  • 5’, 3’-modifications such as 5’-, 3’-amino, 5’-, 3’-thiol, etc..
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U29-S03. Special nucleotides for oligonucleotide synthesis. (Remote) OUTSTANDING

Special nucleotides for oligonucleotide synthesis

For those services identified as outstanding, at least 20% of their capacity is open under competitive access. See Annex 1 of ACCESS PROTOCOL (provided by Nanbiosis) for details on % of openness for each service

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U29-S01. Synthesis of oligonucleotides and characterization (On-site & Remote). OUTSTANDING

Synthesis of oligonucleotides at various different scales (100 mg to 5 mg) and purification using HPLC and/or desalting.

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U19-S02. Animal Model Studies (Onsite&Remote) OUTSTANDING

Preclinical regulatory in vivo toxicity, local and systemic tolerance and PK/PD studies; dosing of test and specimen drawing, biocompatibility studies of medical devices; Molecular biology techniques; Cell culture techniques; Flow cytometry; Safety studies: Nervous, cardiovascular and respiratory systems.

Security testing of advanced therapies using small and large animals models.

Sample preparation, inclusion, section and staining for preclinical histology (paraffin and frozen samples) as well as anatomopathological evaluation.

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U10-S09. Characterization and development of pulmonar formulations (On-site&Remote) OUTSTANDING

Characterization and development of pulmonar formulations

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U10-S08. 3D bio-impression of scaffolding for regenerative medicine (On-site&Remote) OUTSTANDING

3D bio-impression of scaffolding for regenerative medicine

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U23-S09. Quality control for Human Assisted Reproduction clinics (On-site&Remote) OUTSTANDING

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U23-S08. Oosight system (On-site&Remote) OUTSTANDING

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U23-S07. Laser System and Biopsed of blastomeres (On-site&Remote) OUTSTANDING

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U23-S06. IMSI system (On-site&Remote) OUTSTANDING

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