U10. Drug Formulation
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- Scientific Director: Prof. José Luis Pedraz joseluis.pedraz@ehu.es
- Scientific Coordinator: Dr. Idoia Gallego Garrido idoiagallego@hotmail.com
- Entities: Universidad del País Vasco (UPV/EHU)
- Address: Pharmacy & Pharmac. Technology Lab.; Facultad de Farmacia, C/Paseo de la Universidad 7, 01006 Vitoria-Gasteiz (Spain)
- Phone: +34 653593042
- Fax: +34 945 013040
- Web: NANOBIOCEL UPV/EHU
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Description
Located at the Faculty of Pharmacy, University of the Basque Country (UPV/EHU), Campus of Alava in Vitoria. The Unit is led by Prof. José Luis Pedraz and consists of large laboratories for cell culture, chromatography equipment, sample preparation and characterization, and one specific for scale preparation of pharmaceutical formulations. Recently the group has incorporated 3D bioprinters of the last generation with different technologies based on extrusion, inkjet, among others. It has also incorporated self-assembly equipment of nanoparticles based on microfluidic technologies.
This Unit can design and evaluate dosage forms both classical and new dosage forms of biotech drugs, DNA, RNA, and vaccines using different methodologies based on micro and nano-medicine and the latter technology based on the microencapsulation of cells, peptides, proteins, and in general of biotech products, as well as the development and design of non-viral vectors for gene therapy, is one of the biggest singularities of this Unit. It counts on the most advanced equipment for micro and nanoencapsulation.
The Unit aims to determine experimentally all the variables needed to develop an optimal formulation and work instructions for preparing final pharmaceutical products.
The pharmaceutical technology applied to drug development involves the selection of materials and procedures that can be adapted to different processes that lead to specific pharmaceutical forms. To do that, the Unit10 counts with the most advanced equipment to cover the development for all the steps of the process.
One of the singularities of this Units is that is GLP certified by the Spanish Medicament Agency
Services
FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE
U10. Services & Rates
Active projects
- Inhaled RNA Vaccines Against Tuberculosis. RTC: PMPTA/00143. Call: “Proyectos de I+D vinculados a la medicina personalizada y terapias avanzadas” from the joint initative ISCIII-CDTI. Funding agency: EU Next Generation Ministerio de Ciencia e Innovación CDTI. Duration: May 2024 – May 2026. Role: Partner.
- Nanovectors for direct local-regional and controlled intravenous administration of antitumor drugs. Strategies to minimize adverse effects and maximize therapeutic response. ONCOLIBERYX. RTC: CPP2021-008362. Call: Convocatoria de ayudas para proyectos de colaboración público-privada 2021. Funding agency: Ministerio de Ciencia e Innovación. Duration: May 2022 – May 2024. Role: Partner.
- Unlocking data content of Organ-On-Chips UNLOOC. RTC: 101140192-1. Call: HORIZON-KDT-JU-2023-1-IA-Topic-1. Funding agency: HORIZON Programme. Duration: January 2023 – May 2024. Role: Partner.
- Optimization of a non-viral vector platform based on functionalized niosomes with nanodiamonds for gene therapy in cystic fibrosis. IP: Jose Luis Pedraz Muñoz and Gustavo Puras Ochoa. Funding agency: Ministerio de Ciencia e Innovacion. Funds: € 181.500. Duration: Jun 2020 – Jun 2023
Other projects
| Ref |
Title |
Funding Organism |
Unit Role |
| RTC-2016-4770-1 |
DEVELOPMENT OF A NEW BIOADHESIVE FOR PTERIGIUM SURGERY. BIOTAPE |
MINISTERIO DE ECONOMIA, INDUSTRIA Y COMPETITIVIDAD. |
Participant |
| RTC-2016-5451-1 |
DEVELOPMENT OF BIOIMPRESSION SYSTEMS AND BIOTINES FOR THREE-DIMENSIONAL CARTILAGE AND BONE REGENERATION |
MINISTERIO DE ECONOMIA, INDUSTRIA Y COMPETITIVIDAD. |
Participant |
| RTC-2015-3303-1 |
Lipid solid nanoparticles for subcutaneous administration of antitumor marine compounds - UNDERLIPIDS |
MINISTERIO DE ECONOMIA Y COMPETITIVIDAD |
|
Publications
2016
- Grijalvo S., Puras G., Zarate J., Pons R., Pedraz J.L., Eritja R. et al. Nioplexes encapsulated in supramolecular hybrid biohydrogels as versatile delivery platforms for nucleic acids. RSC Advances. 2016;6(46):39688-39699.
- Moreno-Sastre M., Pastor M., Esquisabel A., Sans E., Vinas M., Fleischer A. et al. Pulmonary delivery of tobramycin-loaded nanostructured lipid carriers for Pseudomonas aeruginosa infections associated with cystic fibrosis. International Journal of Pharmaceutics. 2016;498(1-2):263-273.
- Moreno-Sastre M., Pastor M., Esquisabel A., Sans E., Vinas M., Bachiller D. et al. Stability study of sodium colistimethate-loaded lipid nanoparticles. Journal of Microencapsulation. 2016;33(7):636-645.
- Garcia-Orue I., Gainza G., Gutierrez F.B., Aguirre J.J., Evora C., Pedraz J.L. et al. Novel nanofibrous dressings containing rhEGF and Aloe vera for wound healing applications. International Journal of Pharmaceutics. 2016;:-.
- Ojeda E., Puras G., Agirre M., Zarate J., Grijalvo S., Eritja R. et al. The role of helper lipids in the intracellular disposition and transfection efficiency of niosome formulations for gene delivery to retinal pigment epithelial cells. International Journal of Pharmaceutics. 2016;503(1-2):115-126.
- Ojeda E., Puras G., Agirre M., Zarate J., Grijalvo S., Eritja R. et al. The influence of the polar head-group of synthetic cationic lipids on the transfection efficiency mediated by niosomes in rat retina and brain. Biomaterials. 2016;77:267-279.
News U10
30 Apr
Lluis Montoliu to give a talk on science communication at UPV/EHU on May 6, sharing insights on how to effectively disseminate research from the lab. Vitoria-Gasteiz, may 2025. Lluis Montoliu, renowned researcher from the Spanish National Research Council (CSIC) and expert in biomedical communication, will deliver a talk titled “Keys to Communicating and Disseminating from [...]
10 Apr
NANBIOSIS Unit 10 helps develop eye drops with adalimumab for retinitis pigmentosa, showing promising results in preclinical models. Vitoria, april 2025. A multidisciplinary team of researchers from the Centro de Investigación Biomédica en Red (CIBER), the Centro de Investigación Príncipe Felipe (CIPF), and the University of the Basque Country (UPV/EHU) has developed an innovative eye [...]
28 Feb
NANBIOSIS Unit 10 develops lipid-based nanoparticles for gene and drug delivery, aiming for cost-effective, non-invasive treatments for retinitis pigmentosa. Vitoria, february 2025. Retinitis pigmentosa (RP) is a congenital rare disease that leads to progressive and irreversible vision loss. Both genetic mutations and inflammation contribute significantly to the progression of the disease. Researchers from the Drug [...]
11 Sep
Researchers are advancing gene therapies for cystic fibrosis using non-viral delivery methods, focusing on patient needs and innovative treatments. Basque Country, September, 2024 – As the world comes together to mark World Cystic Fibrosis Day, from NANBIOSIS we want to highlight the collaborative efforts between our Unit 10 “Drug Formulation” (U10), the University of the [...]
09 Sep
Vasque Country, September, 2024 – In this interview, Lucía Enríquez, a PhD researcher at NANBIOSIS Unit 10, discusses her work on gene therapies for cystic fibrosis, a genetic disease that mainly affects the lungs. Her research focuses on using non-viral vectors to deliver gene-editing tools, like Prime Editing, a variation of CRISPR-Cas9, to correct mutations [...]
27 Jun
Madrid, June, 2024 – In a distinguished ceremony held at the Spanish Royal National Academy of Pharmacy (Real Academia Nacional de Farmacia), Professor Jose Luis Pedraz Muñoz, a prominent figure at the University of the Basque Country, was officially inducted as an “Académico de Número”. The highest position within the Royal National Academy of Pharmacy. [...]
13 Nov
On Thursday, November 2, the Female Talent Award, in the category of Women and Science, was awarded to Rosa Hernández from the NanoBioCel group of CIBER BBN and the U10 Drug Formulation Unit. The award is given by AMPEA (Association of Professional and Business Women of Alava). In her award speech, Rosa Hernández, highlighted that [...]
08 Nov
2023 CIBER-BBN Annual meeting has taken place at Santemar Hotel, in Santander during November 6-7. This year the format of our annual conferences has been changed towards a collective event scheme between the CIBER-BBN and CIBEREHD thematic areas. On Monday 6 the scientific sessions werecommon for EHD and BBN, with appealing contents for the mixed [...]
15 Oct
On the 20th of October, CIBER-BBN group NanoBioCell – NANBIOSIS U10 Drug Formulation unit organises the Conference “Developping support technologies for adressing traslational gaps in regenerative medicine” by Dr. James-J Yoo. The Conference will take place in the Assembly hall of the Faculty of Pharmacy on Friday 20th of October, 2023 from 12:00 to 13:00, [...]
02 Oct
Researchers of CIBER-BBN group NanoBioCell – NANBIOSIS U10 Drug Formulation unit Jose Luis Pedraz Muñoz, Laura Saenz del Burgo Martínez, Gustavo Puras Ochoa, Jon Zarate Sesma have edited the book “3D Printing and Bioprinting for Pharmaceutical and Medical Applications” The increasing availability and decreasing costs of 3D printing and bioprinting technologies are expanding opportunities to meet medical needs. 3D [...]
