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U13. Tissue & Scaffold Characterization Unit

U13. Tissue & Scaffold Characterization Unit

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U13-E04. Micro-scale tension-compression test system CellScale.

Test system for small samples including:

  • Main equipment (Micro-scale tension-compression test system)
  • Tangential test module (Shear Axis add-on for MicroTester system)

Description: Enhanced for smaller samples, the MicroTester offers improved force resolution, streamlined test setups, and exceptional visual feedback. It’s ideal for a wide range of applications, from tiny tissue samples to hydrogel microspheres, cell spheroids, and engineered microtissues.

Technical specifications: Piezo-electric actuators with 0.1µm resolution Optional second axis imaging Force resolution down to 10nN High resolution CCD imaging Integrated temperature-controlled media bath Fully featured user interface software for simple, cyclic, relaxation, and multi-modal testing with real-time feedback

Aplications: Compression, tension, bending, indentation and shear testing

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U13-S09. Compression-shear test cellscale MicroTester G2

Compression-shear test cellscale MicroTester G2

Compression and shear test applied to a wide range of biomaterial and soft tissues. Force is measured using the difference between the tip and base displacement and the stiffness of the beam that connects them.
Mechanical and viscoelastic properties can be measured.

Customer benefits

  • Adaptable system to the material stiffness properties.
  • Well define testing protocols.
  • Tests are recorded in high definition.

Target customer

Public and private research groups focused on biomaterials and tissue mechanical characterization.

References

Nicolás Laita, Ricardo M. Rosales, Ming Wu, Piet Claus, Stefan Janssens, Miguel Ángel Martínez, Manuel Doblaré, Estefanía Peña, On modeling the in vivo ventricular passive mechanical behavior from in vitro experimental properties in porcine hearts, Computers & Structures, 292, 2024, 107241, ISSN 0045-7949, Doi: 10.1016/j.compstruc.2023.107241.

Additional information

Used in BravE project (https://projectbrave.eu/)

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U13-S08. Atomic Force Microscopy indentation test

Atomic Force Microscopy indentation test

Atomic Force Microscopy can be used to measure the forces between the probe and the sample as a function of their mutual separation. This can be applied to perform force spectroscopy.

Customer benefits

Low forces on cells (nano-scale).

Target customer

Public and private research groups focused on mechanobiology

Additional information

Cantilever + cells
Force curve
Capsules
AFM Software
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U13-E3. Atomic Force Microscopy

AFM: Atomic Force Microscopy JPK. AFMs can be used to measure the forces between the probe and the sample as a function of their mutual separation. This can be applied to perform force spectroscopy.

 

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U13-E02. Machines for mechanical tests

Machines for mechanical tests:

• Instron MicroTester 5848 and 5548: electromechanical machines for displacement or load control tests:

•• load range from 1mN to 2kN at full scale.
•• load cells of:+/- 5, 50, 500 and 1000N.
•• synchronous data capture in all the channels up to
500 Hz.
• Biaxial Instron MicroTester 8874: axial-torsional, servohydraulic testing machine:
•• load capacity of 25 kN and 100 Nm.
•• fatigue tests at a low number of cycles.

›› Software for data control and analysis.
›› Accessories and tools especially designed by the group, which allow a wide flexibility in designing tests, allowing the verification and/or validation of theoretical models.
›› AVE video extensometer connected to the machines; resolution of 0.5 μm. To determine the axial and transverse deformation without contact (tension, dynamic properties and viscoelasticity) of the samples.

• E1000 Test Instrument: Dynamic systems to offer slow-speed static testing and high-frequency dynamic fatigue testing with hundreds of Hertz capability: Load range: 250 N to 2.0 KN.
• Nano BIONIX MTS: For nanomechanical characterization of biomaterials. Load range to 0.001N to 0.5N.

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U13-E01. MicroCT GE eXplore Locus SP (GE)

MicroCT GE eXplore Locus SP (GE): Computed X-ray Axial Tomograph for the non-destructive study of the microstructure and in vitro tomography: ›› Samples of up to 40 mm in diameter; resolution of 10 μm. ›› Different types of tissues, implants, scaffolds, etc. ›› Complete “section-by-section” imaging with a single rotation (cone beam volumetric technology); excellent image quality and “signal-to-noise” ratio. ›› “Bone Analysis Tool” software provided with: •• BMD (Bone Mineral Density): It calculates the density of minerals in the bone, the bone volume fraction and the mineral content in the bone. •• Anisotropy: It determines the degree of symmetry and the orientation of the trabecular structure. •• Cortical Analysis: It determines “section-by-section” the width, surface area and the BMD value of the cortical bone. •• Stereology: It provides the bone volume fraction, the ratio between the surface of the bone and its volume and the width of the trabecular plate. •• Direct Measures: It determines the local trabecular width of a bone and allows obtaining a visual representation of this local width.

Temporarily OUT OF ORDER

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U13-S01. MicroCT

MicroCT

X-Ray image for biomaterials, scaffolds and biological tissues.

Customer benefits

An axis inside is able to apply forces.
Non-destructive view of internal structure pre and post force.

Target customer

Public and private research groups focused on biomaterials and tissue mechanical characterization.

Additional information

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U13-S03. Fatigue tests Instron 8874

Fatigue tests Instron 8874

Fatigue tests allow us to know how is the behaviour when cyclic load are applied. It is used for life expectancy of biomaterials and biological tissues.

Customer benefits

High full-scale cell load.

Target customer

Public and private research groups focused on biomaterials and tissue mechanical characterization.

Additional information

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U13-S04. Dynamic mechanical analysis Instron 8874

Dynamic mechanical analysis Instron 8874

Dynamic tests allow us to know how is the behaviour along time. It is used for viscoelastic properties of biomaterials and biological tissues.

Customer benefits

High full-scale cell load.

Target customer

Public and private research groups focused on biomaterials and tissue mechanical characterization.

Additional information

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U13-S05. Uniaxial test Instron MicroTester

Uniaxial test Instron MicroTester

Tensile, pure shear and planar tension are the tests inside the uniaxial group. Samples are stretched along an axis by measuring force and displacement. Cycling protocols can be integrated into the mechanical test. Mechanical and viscoelastic properties can be studied. Force is measured by means of load cells.

Customer benefits

  • Load cells are available with different full-scales depending on the material to test.
  • Tests can be controlled by means of displacement or force.
  • Specific protocols according customer requirements.
  • Tracking system can be used to measure real deformations.
  • Adaptable clamps according to sample geometry.

Target customer

Public and private research groups focused on biomaterials and tissue mechanical characterization.

References

  • Ríos-Ruiz, I., Martínez, M.Á. & Peña, E. Is location a significant parameter in the layer dependent dissection properties of the aorta?. Biomech Model Mechanobiol 21, 1887–1901 (2022). Doi: 10.1007/s10237-022-01627-9
  • Peña E, Alastrué V, Laborda A, Martínez MA, Doblaré M. A constitutive formulation of vascular tissue mechanics including viscoelasticity and softening behaviour. J Biomech. 2010 Mar 22;43(5):984-9. doi: 10.1016/j.jbiomech.2009.10.046. Epub 2009 Dec 2. PMID: 19959171.

Additional information

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