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U21. Experimental operating rooms

U21. Experimental operating rooms

U21-S01. In vivo Efficacy Assays of drugs, nanomedicines, biomaterials and others

In vivo Efficacy Assays of drugs, nanomedicines, biomaterials and others

Preclinical studies for the evaluation of medical treatments, medical devices and surgical techniques in a controlled environment prior to their application in patients.
Conducting studies -both in human and veterinary medicine- of in vitro toxicity, in vivo toxicity, tolerance, pharmacodynamics, test product administration and procurement of non-clinical specimens, biocompatibility of medical devices, murine model embryo transfers, intracytoplasmic microinjection, oocyte vitrification, measurement and analysis of Natural Killer (NK) cell samples, seminogram and semen studies.
Creation of experimental animal models of various human diseases such as diabetes, obesity, hypercholesterolemia, hypertriglyceridemia, acute and chronic myocardial infarction, prostatic hyperplasia, ulcers, pleural adhesions, constrictive pericarditis and abdominal aortic aneurysm, among others. Possibility of working with a variety of animal species: rodents, rabbits, dogs, cats, pigs and sheep.
Application of experimental animal models for research in several longitudinal areas such as cardiovascular, hepatic and digestive, respiratory and systemic diseases, endocrinology and urology, gynecological and reproductive diseases, prostheses, among others.

Customer benefits

Preclinical studies can be carried out under good laboratory practice (GLP 23.05/001 AEMPS), optimal for reporting to the AEMPS, EMA and FDA.
In vivo toxicity, tolerance, pharmacodynamics, test product administration and non-clinical specimen collection and biocompatibility studies of medical devices are carried out according to OECD decision C(89)87.
Registered facilities for the use and breeding of experimental animals, which has an Animal Welfare Ethics Committee and a pharmacy and formulation laboratory.

Target customer

Entities involved in the research, development or commercialization of medical devices or treatments such as pharmaceutical and biotechnology companies, academic and scientific researchers, medical device companies, research institutions and laboratories, and governmental and regulatory organizations.

Additional information

  • Jiménez-Holguín J, Lozano D, Saiz-Pardo M, de Pablo D, Ortega L, Enciso S, Fernández-Tomé B, Díaz-Güemes I, Sánchez-Margallo FM, Portolés MT, Arcos D. Osteogenic-angiogenic coupled response of cobalt-containing mesoporous bioactive glasses in vivo. Acta Biomater. 2024 Mar 1;176:445-457. doi: 10.1016/j.actbio.2024.01.003. Epub 2024 Jan 6. PMID: 38190928.
  • Lucas-Cava V, Sánchez-Margallo FM, Moreno-Lobato B, Dávila-Gómez L, Lima-Rodríguez JR, García-Martínez V, López-Sánchez C, Sun F. Prostatic artery occlusion: initial findings on pathophysiological response in a canine prostate model. Transl Androl Urol. 2022 Dec;11(12):1655-1666. doi: 10.21037/tau-22-423. PMID: 36632152; PMCID: PMC9827397.
  • Arcos D, Gómez-Cerezo N, Saiz-Pardo M, de Pablo D, Ortega L, Enciso S, Fernández-Tomé B, Díaz-Güemes I, Sánchez-Margallo FM, Casarrubios L, Feito MJ, Portolés MT, Vallet-Regí M. Injectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions. Acta Biomater. 2022 Oct 1;151:501-511. doi: 10.1016/j.actbio.2022.07.067. Epub 2022 Aug 3. PMID: 35933104.
  • Soria F, de La Cruz JE, Caballero-Romeu JP, Pamplona M, Pérez-Fentes D, Resel-Folskerma L, Sanchez-Margallo FM. Comparative assessment of biodegradable-antireflux heparine coated ureteral stent: animal model study. BMC Urol. 2021 Feb 28;21(1):32. doi: 10.1186/s12894-021-00802-x. PMID: 33639905; PMCID: PMC7916282.
  • Marinaro F, Casado JG, Blázquez R, Brun MV, Marcos R, Santos M, Duque FJ, López E, Álvarez V, Usón A, Sánchez-Margallo FM. Laparoscopy for the Treatment of Congenital Hernia: Use of Surgical Meshes and Mesenchymal Stem Cells in a Clinically Relevant Animal Model. Front Pharmacol. 2020 Sep 25;11:01332. doi: 10.3389/fphar.2020.01332. PMID: 33101010; PMCID: PMC7546355.
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U21-E01. Experimental operating rooms for small and large animal

Experimental operating rooms for small and large animal (inhalation anesthesia workstation, infusion pumps, electrocoagulation systems, laparoscopic surgery systems, endoscopic surgery, microsurgery, interventional and endoluminal surgery, orthopedics, etc.)

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U21-E02. Rooms for preparation and preanesthesia

Rooms for preparation and preanesthesia

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U21-E03. Sterelization rooms for medical instruments and tools

Sterelization rooms for medical instruments and tools

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U21-E04. Integrated operating room

(Karl Storz OR1, Karl Storz Spies) with possibility of integrating endoscopy images, cameras, documents, communications, etc., Allowing data transfer, videoconferences from a touch screen or voice.
Single-pole and two-pole electrosurgical generators (Force Triad Valleylab, Karl Storz AUTOCON® II 200, Erbe ICC 300, Erbe VIO 310, Erbe ICC 200, Ultracision Harmonic scalpel, Ligasure Valleylab, Sonicision)

Laparoscopic surgery equipments: nineteen high definition laparoscopic towers (Karl Storz-Endoskope) equipped with monitors, cold light source, insuflator (Thermoflator), susction and irrigation system (Endomat) and optics with different calibers and view angles. In addition, four of them have incorporated a Visualization Enhancement Tools system (Karl Storz Image 1 SpiesTM) for fluorescence-based procedures in order to visualize what is hidden from view under conventional white lightand and another two possessed. The KARL STORZ 3D system which offers the surgeon excellent depth of field combined with outstanding hand-eye coordination.

Endoscopic equipment: Digestive video-endoscope system (Serie 200 Fujinon®) Double Balloon Enteroscopy system (Fujinon® Series 200), Video colonoscopic systems (Olympus® ViseraOlympus® Visera), Video bronchoscopic system (Serie 200 Fujinon®Fujinon® Series 200), Semi-rigid ureteroscopy system (Wolf® 9 Fr.Wolf® 9 Fr), Flexible ureteropieloscopy system (Wolf® 9 Fr.Wolf® 9 Fr). Semi-rigid ureteroscopy system (Storz® 9.5 Fr., 43 cm long). Semi-rigid ureteroscopy system (Storz® 7 Fr, 43 cm long)

Surgical microscopes Zeiss Opmi Pico (13 units), Zeiss Opmi Movena and Zeiss Opmi Pentero 800 (with fluorescence module).

Ophthalmology equipment: corneal topographer (CSO Eye Top 2005 V.1.0), slit lamp (SL-D4 TopCon) and phacoemulsification system (Sovereign White Star AMO-ABBOTT 2 units and Sovereign Compact White Star AMO-ABBOTT 1 unit), Tonometer (TonoVet ICare), Non-contact lens system vitrectomy SDI 4b (5 units), Optical coherence tomography (OCT) (SLO Optos)

Odontology equipment: Ultrasonic generator for treatment of dental plaque (Newtron P5, Acteon),

Vascular Surgery: Laser Doppler Imager and Transit Time Ultrasound Flowmeter

Anesthesia equipment: 13 high performance anesthesia Workstation (Maquet Flow-i, Dameca Siesta i Whispa, Dameca MRi 508, Heinen+Lowenstein Mod. Leon, Heinen+Lowenstein Mod. Leon Plus, Ohmeda Excel 210 SE, Ohmeda Excel 110 SE, Temel Supra CM, Datex Ohmeda S/5TM); Anesthesia machine for rodents (Surgivet); Transport ventilator (Transpac 200D);

13 isoflurane, sevoflurane and desflurane vaporizer (Maquet, Dameca Sigma Delta, Dräger, Abbott laboratories, Datex Ohmeda Tec 6); 14 cardiovascular monitors (Hewlett-Packard, Mindray PM-700, Mindray MEC 1000, Mindray BeneView T5, General Electric Dash 3000, General Electric Dash 4000, Drager Infinity Gamma, Datex Ohmeda S/5TM, Philips MX-450, Philips Expression MR200); 11 capnography systems (Maquet, Drager Vamos, General Electric RAC 2A, Ohmeda Biox 3740, Sentec, Ohmeda Capnomac Ultima, Dameca siesta) and pulse oximeter (Ohmeda Biox 3740); Cardiac output monitoring system (PICCO Plus) and two bispectral electroencephalogram monitor (BIS-A 1050, BIS –XP A 2000), parasympathetic tone activity monitor (MDoloris PTA) and muscle relaxation monitor (Organon TOF Watch); Four infusion pumps (Argus 600S, Braun Perfusor Compact, Imed Gemini PC1, Becton Dickinson); Two desfibrillators (Zoll Mseries, Nihon Kohden Cardiolife)

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