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News U4

News U4

Laura Lechuga received the Physics, Innovation and Technology Prize

On December 14th, the Physics Awards ceremony was held at the BBVA Foundation’s headquarters, organized by the Spanish Royal Society of Physics (RSEF) and the BBVA Foundation, that each year select the most relevant achievements of Spanish physics. On this occasion the achievements of nanoscience have been recognized and it has been highlighted the power of physics to expand the territory of the known universe and the role of scientists as a core element of social progress.

Professor Laura Lechuga, Scientific Director of Unit 4 of NANBIOSIS received the Physics, Innovation and Technology Prize was the only woman awarded.

Lechuga is a pioneer in Spain in the development of biosensors, devices that integrate in very little volume the analytical capacity of a laboratory, so they have the theoretical potential to revolutionize many technological areas that have a direct impact on society, from medical diagnosis to control of contaminants in the environment. The award winner works on two prototypes of nanophotonic biosensors to detect colon cancer and tuberculosis: “The future of immediate diagnosis goes through such devices, low cost and very high sensitivity, installed in mobile phones, which could be easily used also in regions in development” says professor Lechuga.

Laura Lechuga received the Physics, Innovation and Technology Prize
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Physics Prize of the Royal Spanish Society of Physics (RSEF) to Laura Lechuga

Laura M. Lechuga, Scientific Director of the Unit 4 of NANBIOSIS has won the Physics Prize of the Royal Spanish Society of Physics (RSEF) -Foundation BBVA 2016 in the form of Physics, Innovation and Technology, endowed with 8,000 euros.

Physics Awards recognize this year to researchers who have revealed the potential of the “nanoworld” to create new materials and fight disease.

The jury highlighted her “excellent track record as a scientist, technologist and innovative” in the field of biosensor devices. “Prof. Lechuga – emphasizes the jury- has managed to walk the path from idea to product with great success. Her work combines high quality science with the development of productive technologies and their transfer to the enterprise system through active participation in the creation of companies in the sector”

Physics Prize of the Royal Spanish Society of Physics (RSEF) to Laura Lechuga
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Laura Lechuga, Scientific Director of the Unit 4 of NANBIOSIS in the Spanish Selection of Science.

The selection of the best Spanish researchers in 2016 is an initiative of the magazine QUO to disseminate the work of scientists. The jury formed by eight eminent scientists (Amils, Ainhoa Goni, Emilio Lora-Tamayo, Vladimir de Semir, Fernando Peláez, Antonio Calvo, Pilar López and Manuel Toharia, has chosen the twelve scientists of international prestige who will form the Spanish National Science 2016:

– Pedro Cavadas, plastic surgeon specializing in transplants

– Mariano Barbacid, a biochemist at the National Cancer Research Centre (CNIO)

– Susana Marcos, director of the Institute of Optics ‘Daza Valdes’ CSIC

– Alberto Ruiz Jimeno, founder of the high energies of IFCA group

– Laura M. Lechuga, research professor at the Catalan Institute of Nanoscience and Nanotechnology and leader of the research CIBER-BBN group Nanobiosensors and Bioanalytical Applications

– Francisco J. Martinez Mojica, a researcher at the University of Alicante and scientific development of CRISPR

– Jose Manuel Galan, Egyptologist and promoter of the project Djehuty

– Juan José Gómez Cadenas, IFIC researcher and director of the experiment Next

– Carmen Martinez, director of Viticulture Group on Biological Mission of CSIC in Galicia

– Mariano Esteban, President of the Royal Academy of Pharmacy

– Mara Dierssen, researcher at the Center for Genomic Regulation in Barcelona

– Miguel Delibes de Castro, a researcher at the Biological Station of Doñana

Laura Lechuga develops innovative devices based on nanotechnology for diagnosis of Several pathologies. In her researches she use the unit 4 of NANBIOSIS of Biodeposition and Biodetection, a system suitable for the functionalization of biosensors With any kind of biomolecule, nanoparticles, graphene or other nanostructures, for surface patterning for cell culture, or for the preparation of micro / nanoarrays, Among other applications, which also harbours to Surface Plasmon Resonance (SPR) service.

Laura Lechuga, Scientific Director of the Unit 4 of NANBIOSIS in the Spanish Selection of Science.
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Nanotechnology bio applications in the clinical diagnosis II: biosensor BiMW for the early diagnosis of bacterial infections in cirrhotic patients

The peritonitis bacterial spontaneous is an infection of the fluid ascetic that has high incidence in cirrhotic patients and is associated with a high mortality. In such situation, a diagnosis early is essential for the survival of the patient. However, the identification of the causative pathogen of infection is based currently on cultivation methods that are slow and laborious.

A research coordinated by the Group of Nanobiosensors and Bioanalytical applications of the CIBER-BBN, which coordinates Unit 4 of NANBIOSIS led by Laura Lechuga, has presented the development of a biosensor interferometric based in guides bimodal (BiMW), capable of identify and quantify E. coli in liquid ascetic reaching some limits of detection below them 100 cfu /mL in only 15 min of analysis. These results demonstrate the great capacity of the biosensor BiMW as a new tool in the field clinical for the analysis microbial due to its ease use and its good relationship of cost-effectiveness and speed in the microbiological analysis.

Article of Reference:  Label-free bimodal waveguide immunosensor for rapid diagnosis of bacterial infections in cirrhotic patients. Jesús Maldonado, Ana Belén González-Guerrero, Carlos Domínguez, Laura M.Lechuga. Biosensors and Bioelectronics.

Nanotechnology bio applications in the clinical diagnosis II biosensor BiMW for the early diagnosis of bacterial infections in cirrhotic patients
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Nanotechnology bio applications in the clinical diagnosis: nanoplasmodic biosensor device for the early diagnosis of colorectal cancer

The group of Nano-biosensors and Bioanalytical applications of CIBER-BBN which coordinates Unit 4 of NANBIOSIS directed by Dr. Laura Lechuga, has led the final preparations of a technology with potential application in the early diagnosis of colorectal cancer, based in the detection of specific biomarkers in blood.
The nanoplasmonic biosensor based on LSPR (Localized Surface Plasmon Resonance) is generated on structured surfaces of nano discs of gold, that allow monitoring of biological interactions in real time and without the need of markers.
The nanoplasmonic biosensor allows analysis of human samples in a few minutes, without requiring reagents or additional instrumentation. The device is easy to use and its reduced dimensions offer an attractive opportunity for the development of point-of-care devices with potential to be used outside the laboratory.

Article of Reference:  Label-free nanoplasmonic sensing of tumor-associate autoantibodies for early diagnosis of colorectal cancer.Maria Soler, M. Carmen Estevez, Roi Villar-Vázquez, J. Ignacio Casal, Laura M. Lechuga. Analytica Chimica Acta. http://dx.doi.org/10.1016/j.aca.2016.04.059

Nanotechnology bio applications in the clinical diagnosis nanoplasmodic biosensor device for the early diagnosis of colorectal cancer
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