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U6. Biomaterial Processing and Nanostructuring Unit

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U6. Biomaterial Processing and Nanostructuring Unit

    • Scientific Director: Prof. Nora Ventosa ventosa@icmab.es 
    • Scientific Coordinator: Dr. Eduardo Pérez eperez2@icmab.es 
    • Entities: Instituto de Ciencia de Materiales de Barcelona ICMAB-CSIC
    • Address: Campus de UAB, 08193, Bellaterra, Barcelona, Spain
    • Phone: +34 935 801 853
    • Fax: +34 935 805 729
    • Web: ICMAB

ICMAB CSIC

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U6. Compressed fluids based biomaterials processing platformU6. Compressed fluids based biomaterials processing platform
U6. Dynamic light scattering for particle size and Z potential measurementsU6. Dynamic light scattering for particle size and Z potential measurements
U6. Compressed fluids based biomaterials processingU6. Compressed fluids based biomaterials processing

Description

Located at the Instituto de Ciencia de Materiales de Barcelona (ICMAB-CSIC), in Barcelona, and under the coordination of Professor Jaume Veciana and Prof. Nora Ventosa, current directors of NANOMOL Group, which is a research group with wide expertise and recognized excellence in the synthesis, processing and study of molecular and polymeric materials with chemical, electronic, magnetic and biomedical properties.  It gathers several laboratories, perfectly equipped, to perform the mission of this facility: the development, characterization, and large-scale production of molecular biomaterials of therapeutic or biomedical interest, with controlled micro-, nano- and supramolecular structure. One example of Key-Enabling-Technology (KET) available in this unit is a simple one-step methodology, DELOS-SUSP, based on the use of compressed fluids (CF), such as CO2, to prepare particulate materials with precise and reproducible structural characteristics at micro-, nano- and supramolecular levels (size, shape, internal structural gradients, supra­molecular organization and crystalline purity). This example shows one of the singularities of this unit is that counts with CF–based plants at different scales, from mL to L, which allow process development by QbD and process scale-up.
The NANBIOSIS Unit 6 is also applying for the ISO9001 certification for standard quality control system
 




 




 



		
Services

		

			



FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE 
		
U6. Services & Rates

		
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Active projects

		

			


	






Title
Fundin: Organism
Call: Funding source 
Role







GA: 720942

SMART FUNCTIONAL GLA-NANOFORMULATION FOR FABRY DISEASE – Smart-4-Fabry
Unión Europea (Comisión Europea)
H2020-NMBP-2016-2017
Coordinator




SAF2017-90810-REDI

Strategic Promotion and coordinated management of Nanbiosis: Pronanbiosis II
Agencia Estatal de Investigación (AEI)
Acciones de dinamización  «REDES DE EXCELENCIA»

-ICTS 2017		
Coordinator







		

		
Other projects

		

			


	




Ref
Title
Funding Organism
Unit Role







PI15/00272
Design of intelligent nanoconjugates for the treatment of metastatic colorectal cancer.
Instituto de Salud Carlos III
Participant




H2020-MSCA-ITN-2014-642196
Integrated self-assembled SWITCHable systems and materials: towards responsive organic electronics - a multi-site innovative training action i-Switch
Unión Europea H2020
Participant




2014 SGR 17
Consolidation Research Group: Molecular Nanociènciai Materials Orgànics (NANOMOL)
Generalitat de Catalunya
Participant




CTQ2013-40480-R
Molecular Bio- and Electro-active materials for the improvement of health and social well-being (Be-Well)
MICINN
Participant




FP7-PEOPLE-2013-ITN nº 607721
Nanochemistry of molecular materials for 2-photon functional applications. Nano2Fun
Unión Europea
Participant




MAT2013-50036-EXP
Cell Surface Vessel Engineering Using Dynamic Molecular Bioinfecting (DYNAMO)
MINECO
Participant




RTC-2016-4567-1
Nanocapsules containing active ingredients for the topical treatment of dermatological diseases (NANO4DERM)
MINECO
Participant




RTC-2014-2183-S
Application of Quatsomes technology for the development of a new range of perfumed softeners with lower environmental impact
MINECO
Participant




201260E080
Self-assembly, Nanostructuring and Processing of Functional Organic Molecules and their Applications
Ministerio de Ciencia e Innovación
Participant




MAT2016-80826-R
Molecular materials and supramolecular organizations for therapy, diagnosis and tissue engineering (MOTHER)
MINECO
Participant




RTC-2014-2207-1
TERARMET: Development of therapies for the treatment of rare congenital metabolic diseases
MINECO
Participant







		

		
Publications

		

			2016




    

  • Munoz-Gomez J.L., Monteagudo E., Lloveras V., Parella T., Veciana J., Vidal-Gancedo J.. Optimized polarization build-up times in dissolution DNP-NMR using a benzyl amino derivative of BDPA. RSC Advances. 2016;6(32):27077-27082.
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  • Cordoba A., Hierro-Oliva M., Pacha-Olivenza M.A., Fernandez-Calderon M.C., Perello J., Isern B. et al. Direct Covalent Grafting of Phytate to Titanium Surfaces through Ti-O-P Bonding Shows Bone Stimulating Surface Properties and Decreased Bacterial Adhesion. ACS Applied Materials and Interfaces. 2016;8(18):11326-11335.
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  • Cabrera I., Abasolo I., Corchero J.L., Elizondo E., Gil P.R., Moreno E. et al. α-Galactosidase-A Loaded-Nanoliposomes with Enhanced Enzymatic Activity and Intracellular Penetration. Advanced Healthcare Materials. 2016;5(7):829-840.
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  • Cano-Garrido O., Sanchez-Chardi A., Pares S., Giro I., Tatkiewicz W.I., Ferrer-Miralles N. et al. Functional protein-based nanomaterial produced in microorganisms recognized as safe: A new platform for biotechnology. Acta Biomaterialia. 2016;43:230-239.
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News U6
16 May
Nora Ventosa appointed Research Professor under the Materials Science
Nora Ventosa, the Scientific Director of NANBIOSIS U6 of Biomaterial Processing and Nanostructuring Unit (and IP of the NANOMOL Group of CIBERBBN at ICMAB-CSIC) has been appointed Research Professor in the last call of the Spanish National Reserach Council (CSIC) This elective process for the selection and appointment of career civil servant, by internal promotion, in the Scale of Research Professors of Public Research Organisms had oppen 6 new positions for Professors under the Materials Science. Nora Ventosa is a Chemical Engineer by the Institut Químic de Sarrià (IQS) and Doctor in Chemistry by the Universitat Ramon Llull. Her researc[...]
08 Apr
ISO 9001:2015 Quality Certification for the Soft Scientific and Technical Service at ICMAB and Unit
The aim of the quality certification obtained is to ensure the quality of the service provided and to continue with its improvement and extension to future services. The Scientific and Technical Service for the characterization of nano and biomaterials, the Soft Lab, run by the Nanomol Research Unit of the Institute of Materials Science of Barcelona (ICMAB, CSIC), and which is part of Unit 6 of the ICTS Nanbiosis, and CIBER-BBN, aims to offer characterization services of micro- and nanostructured soft molecular materials to the entire scientific community that requires them. To this end, the Soft technical service has several laboratories at[...]
28 Feb
Fabry Desease in the Rare Disease Day: A New Hope
WHY DO CELEBRATE TODAY THE INTERNATIONAL #RareDiseaseDay? 29 of February is a ‘rare’ date and February, a month with a ‘rare’ number of days, has become a month to raise awareness about rare diseases and their impact on patients’ lives.  Since 2008 thousands of events happen every year all around the world and around the last day of February with the aim of improving equity and reducing stigmatization for people who live with more than 6,000 rare diseases. WHAT ARE RARE DISEASES Rare diseases are pathologies or disorders that affect a small part of the population (less than 5 per 10,000 inhabitants) and[...]
04 Feb
Stable nanovesicles for the delivery of microRNA in cancer treatment
Nanovesicles, known as quatsomes, have been successfully engineered to encapsulate and deliver microRNAs for the treatment of tumors.These nanovesicles are produced by a simple GMP compliant process, an unavoidable requirement for the clinical use of new drug candidates.The study, published in Small, has been highlighted in the Women in Materials Science issue of Advanced Materials. “The beauty of these quatsomes nanovesicles is that they can be easily engineered for the delivery of a variety of nucleic acids. Importantly, they are stable at room temperature, which avoids problems associated to cold chain requirements”, says Nora Ventosa, Scientific Director of NANBIOSIS U6.[...]
24 Jan
Submissions open for Special Issue of MDPI on Fluorescent Organic Nanoparticles for Bioimaging and Theragnostics
Nora Ventosa and Mariana Köber, from NANBIOSIS Unit 6 of CIBER-BBN and ICMAB-CSIC, and Judit Morlà-Folch, from the BioMedical Engineering and Imaging Institute at the Icahn School of Medicine at Mount Sinai, New York, are editors of the Special Issue of MDPI Pharmaceutics. The Special Issue on “Fluorescent Organic Nanoparticles for Bioimaging and Theragnostics“ belongs to the “Nanomedicine and Nanotechnology” section and has a deadline for manuscript submissions on 25 July 2022. The guest editors explain the main topic of this Special Edition: “Fluorescence-based techniques play an essential role in the study of biological events in tissues and animals due to their specificity and noninvasive nature. However,[...]
12 Jan
New fluorescent nanovesicles for intracellular biomarker detection
A new work by researchers from the CIBER-BBN at the Barcelona Institute of Materials Science ICMAB-CSIC, together with a team from the University of Rome Tor Vergata, presents new nanovesicles capable of crossing biological barriers such as cell membranes, maintaining their sensory capacity, making them attractive probes for intracellular biomarker detection. “The development of probes capable of detecting the biological environment and signaling the presence of a specific target molecule is a challenge with relevance in a variety of biomedical applications, from drug administration to diagnostic tools” says Mariana Köber, one of those responsible of the investigation together with Nora[...]
03 Dec
‘SAFE-N-MEDTECH’ and ‘PHOEHIX’ OITBs in CIBER-BBN and NANBIOSIS annual Conference.
National and international leading researchers met online last November 15 and 16 at the XV CIBER-BBN Annual Congress to discuss the latest advances in bioengineering, biomaterials and nanomedicine research, and promote further collaborations in the field. This year’s CIBER-BBN Annual Conference included three plenary lectures given by internationally recognized experts in the fields of SARS-CoV-2 infection and vaccination, biomedical signal processing for sleep disorders, and regenerative medicine and biosensors. In addition to a selection of internal collaborations, valorization projects and collaboration projects with the CIBER of Oncology, the three programs of the Precision Medicine Infrastructure (IMPaCT) were presented. NANBIOSIS ICTS[...]
25 Oct
NANBIOSIS U6 opens its doors to students of Nanoscience and Nanotechnology Degree at UAB
NANBIOSIS U6, Biomaterial Processing and Nanostructuring Unit from CIBER-BBN and ICMAB-CSIC, has received today the visit of students of the 4th year degree in Nanoscience and Nanotechnology of the Auonomous University of Barcelona. During this visit, the students had the opportunity to get known of the facilities of Unit 6 of NANBIOSIS ICTS and the to work in a research laboratory. José Amable Bernabé has, Technical Coordinator of the unit, has shown the students the equipment for processing materials with compressed fluids and also some equipment for the characterization of particulate materials. In the Degree in Nanoscience and Nanotechnology at[...]

		
		
	

											

											U6-Biomaterial Processing and Nanostructuring Unit											

												
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U9. Synthesis of Nanoparticles Unit

												

		
		
Ciber bbn


U9. Synthesis of Nanoparticles Unit




    

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    • Entities: Institute of Nanoscience of Aragón (INA)
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    • Address: R&D Building, Campus Río Ebro, Universidad de Zaragoza. C/Mariano Esquirl S/n, 50018, Zaragoza, Spain
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    • Phone: 34 976 761000 ext. 3496
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 Nanabiosis-logo Universidad de Zarargoza-U9-U13-U27.


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U9. Synthesis of Nanoparticles- plasmonic nanoparticles 1U9. Synthesis of Nanoparticles- plasmonic nanoparticles 1
U9. Synthesis of Nanoparticles- hollow magnetic nanoparticlesU9. Synthesis of Nanoparticles- hollow magnetic nanoparticles
U9. Synthesis of Nanoparticles- Laser pyrolysis device and reaction areaU9. Synthesis of Nanoparticles- Laser pyrolysis device and reaction area


Description


This unit, integrated in the Nanostructured Films and Particles Group at the Institute of Nanoscience of Aragón (INA) coordinated by Dr. Jesús Santamaría, has as objective the synthesis of nanoparticles with applications in biomedicine. The unit provides an automated system for the synthesis of nanoparticles using laser-induced pyrolysis of chemical precursors in gas and/or aerosol phase, which enable either individual nanoparticles or biocompatible hybrid nanostructures to be produced in large quantities. In addition, this facility is able to draw on a wide range of nanoparticles fabrication technique, as well as having the necessary specialized personnel, to undertake exhaustive characterization of the microstructure, chemical composition, particles size and distribution of sizes, as well as magnetic, optical and colloidal properties and degree of biological functionality of the synthesized material.



		
Services

		

			



FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE



		
U9. Services & Rates

		
Equipments

		

			



In addition to this there is immediate access to advanced electron microscopies (SEM, TEM, HRTEM, UHRTEM), as well as other surface analysis and characterization equipment (XPS, XRD, FTIR, magnetic characterization). The equipment available makes this Unit unique to produce a wide variety of nanoparticles, , inorganic, polymeric, or multifunctional hybrid nanocomposites. 
		

		
		
	

		
		

		
Active projects

		

			


	






Title
Fundin: Organism
Call: Funding source 
Role







SAF2017-90810-REDI

Strategic Promotion and coordinated management of Nanbiosis: Pronanbiosis II
Agencia Estatal de Investigación (AEI)
Acciones de dinamización «REDES DE EXCELENCIA» -ICTS 2017
Partner




PICCOLO-732111

Multimodal highly-sensitive PhotonICs endoscope for improve in vivo COLOn Cancer diagnosis and clinical decision support
European Commission-H2020
H2020-ICT-2016-1
Partner




0624_2IQBIONEURO_6_E

Promotion of an R&I network in biological chemistry for the diagnosis and treatment of neurological diseases
European Union Interreg : European Territorial Co-operation
POCTEP Interreg España-Portugal
Partner







		

		
Other projects

		

			


	




Ref
Title
Funding Organism
Unit Role







CTQ2014-52384-R
INTELLIGENT APPLICATIONS BASED ON NANOSTRUCTURED FIBERS CONTAINING NATURAL BIOCIDES WITH PHARMACOKINETIC CONTROL OF THEIR RELEASE
Ministerio de Economia y Competitividad
Participant




CTQ2013-49068-C2-1-R
MICROSYSTEMS BASED ON NANOSTRUCTURES WITH SPECIFIC PROPERTIES OF ADSORPTION AND SUPERFICIAL PLASMON, FOR DETECTION OF HIDDEN EXPLOSIVES AND AGENTS OF CHEMICAL WAR.
Ministerio de Economia y Competitividad
Participant




TARMAC
TARMAC. New tools for the diagnosis and treatment of respiratory infectious diseases: pH-responsive matryoshka nanoparticles for an efficient and controlled intracellular delivery of oral antibiotics and gated nanoparticles for the detection of pathogenic microorganisms showing intracellular persistence
Ministerio de Economia y competitividad
Participant




TARMAC/IQMA-UDM-UPV
pH-responsive matryoshka nanoparticles for an efficient and controlled intracellular delivery of oral antibiotics and gated nanoparticles for the detection of pathogenic microorganisms showing intracellular persistence
CIBER-BBN-CIBERES-SEPAR
Participant




H2020-MSCA-ITN-2016/H2020-MSCA-ITN-2016
European Training Network for Continuous Sonication and Microwave Reactors.
Unión Europea
Participant




H2020-SPIRE-2014-2015 
ADREM / Adaptable Reactors for Resource- and Energy-Efficient Methane Valorisation
Unión Europea
Participant




I-2012/023
Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications
Unión Europea
Participant




CTQ2016-77147-R
NEW STRATEGIES FOR CO2 CONVERSION USING CATALYSTS UNDER ELECTROMAGNETIC RADIATION.
MINECO. MINISTERIO DE ECONOMIA Y COMPETITIVIDAD
Participant




CTQ2016-79419-R
ADVANCED ADSORPTION TECHNOLOGIES, SERS DETECTION AND CATALYSIS FOR CHEMICAL WAR
MINECO. MINISTERIO DE ECONOMIA Y COMPETITIVIDAD
Participant




NANOHEDONISM
A photo-triggered on-demand drug delivery system for chronic pain
European Research Council
Participant




I-2011/004
HECTOR- MICROWAVE-ASSISTED MICROREACTORS: DEVELOPMENT OF A HIGHLY EFFICIENT GAS PHASE CONTACTOR WITH DIRECT CATAYST HEATING
Unión Europea
Participant




FIS PI15/01118
Towards an advanced therapy of bone regeneration: tissue intermediates activated by infrared energy for the controlled expression of osteogenic and angiogenic factors
INSTITUTO DE SALUD CARLOS III
Others




AMBIT
Animal Model of Bone Regeneration Induced by Tissue Intermediates Responsive to Near-Infrared Light
Roche Farma
Participant







		

		
Publications

		

			2016


    

  • Sebastian V., Smith C.D., Jensen K.F.. Shape-controlled continuous synthesis of metal nanostructures. Nanoscale. 2016;8(14):7534-7543.
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News U9
02 May
Wide representation of NANBIOSIS research in NALS 2022 and best Oral Presentation to Eloi Parladé
During the last 27-29 April, the 3rd International Conference on Nanomaterials Applied to Life Sciences 2022 (NALS 2022) has taken place in the Excellence Campus of Universidad de Cantabria in Santander (Spain), organized by the University of Cantabria and Institute Valdecilla-IDIVAL. NALS 2022 has been a multidisciplinary conference series sharing new results and ideas in the fields of biosensors, lab on a chip, drug delivery nanopharmacy. nanobiotechnology, intelligent nanomaterials, magnetic materials, nanotoxicity, antimicrobials, novel applications of 3d bioprinting and nanoimaging. NANBIOSIS has been represented at this edition by members of several of its units, among them we must highlight the set of four ora[...]
17 Mar
Gold Nanoparticles Synthesized by NANBIOSIS U9 will destroy tumor cells without drugs
A CIBER-BBN team at the University of Zaragoza has developed intelligent shuttles (cell vesicles -exosomes-) to transfer nanoparticles to the interior of tumor cells and destroy them by means of heat and without drugs, following the “Trojan horse” strategy. “NANBIOSIS U9, “Synthesis of Nanoparticles Unit has developed the procedure to be able to internalize gold nanoparticles, with surface plasmon in the NIR electromagnetic range, inside extracellular vesicles derived from stem cells. The synthesis of the gold nanoparticles has been produced according to the synthesis procedures of UNIT 9 of the ICTS NANBIOSIS based on the galvanic substitution reaction in t[...]
04 Nov
Colloidal nanocrystals for energy applications
Semiconductors are materials used in a wide ranfe of applications since they are capable of capturing light and allowing us to take advantage of it. In addition, if we reduce its size to the nanometric scale we can activate additional very interesting properties On October 16, “Technoscience and Energy” took place in Inseec, Lyon (France), a science-industry transfer event between French and Spanish companies and researchers from the energy sector in France. Among the invited speakers was María Bernechea Navarro, ARAID Investigator, at the Institute of Nanoscience and Materials of Aragon at University of Zaragoza-INMA. In her talk, entitled “COLLOIDAL[...]
08 Jul
New project ExofluidTT for the production of nanovesicles using microfluidics applicable on Biomedicine
Víctor Sebastián Cabeza, researcher of NANBIOSIS U9 Synthesis of Nanoparticles of CIBER-BBN and the Institute of Nanoscience and Materials of Aragón, INMA, has obtained a research grant in the XX National Contest of the Ramón Areces Foundation in the category of Life and Matter Sciences with a funding of € 112,000 for the development in 3 years of nanovesicles using microfluidic technology. As explained by Victor Sebastian “the characterization of the nanovesicles will be carried with the equiment and expertise of NANBIOSIS Unit 9 The project entitled “Engineering of extracellular vesicles-exosomes using microfluidic technology for its application in biomedicine: ExoFluidTT”[...]
14 Jun
New drug delivery system for prolonged pain relief
The management of musculoskeletal pain is a key challenge due to the short duration of anesthetic effect produced by existing clinical treatments, in addition to their potential side effects. Researchers from the CIBER-BBN, the Institute of Nanoscience and Materials of Aragón (INMA), CSIC-University of Zaragoza and the Institute of Health Research of Aragón (IIS Aragón), in collaboration with researchers from the Faculty of Veterinary Medicine of the University of Zaragoza and with participation of NANBIOSIS Unit 9 Synthesis of Nanoparticles Unit, have developed nanogels loaded with nanocrystals of bupivacaine (an anesthetic commonly used in epidural anesthesia and in the contro[...]
11 Feb
NANBIOSIS Scientific Women in the International Day of Women and Girls in Science
Today February 11 is the International Day of Women and Girls in Science, a day to raise awareness of the gender gap in science and technology. According to the United Nations, while yet women and girls continue to be excluded from participating fully in science, science and gender equality are vital to achieve the internationally agreed development goals, including the 2030 Agenda for Sustainable Development. Thus, in recent years, the international community has made a great effort to inspire and promote the participation of women and girls in science. NANBIOSIS wants to acknowledge  the efforts made by scientific women who struggle every day to contribut[...]
13 Dec
Ignacio García and Javier Bonet present their work on the CADENCE project in a one-minute video
Ignacio García and Javier Bonet, researchers from the Nanoporous Films and Particles (NFP) group and Nanbiosis U9 Synthesis of Nanoparticles Unit of the CIBER-BBN and the Institute of Nanoscience and Materials Science at the University of Zaragoza have presented their work on the CADENCE project in a video of a minute of duration that has been submitted to the #QueSigalaCiencia scientific dissemination contest promoted by the CIBER-BBN. #QueSigaLaCiencia is a campaign on social networks that wants to explain to society, from an optimistic perspective, the importance of research and the work carried out by the research staff of the CIBER.[...]
08 Dec
NANBIOSIS participation in the Technology and business Forum “Technological challenges derived from COVID-19”
The pandemic has led companies and researchers to reorient their plans and projects to meet the demands of society. Different examples of these new challenges will be seen at the next Technology and Business Forum on Thursday, December 10, covering from new tissues, better masks, diagnostic tests, epidemiological models and clinical equipment … All this, from an analysis both from the perspective industrial and research. The Technological and Business Forum is organized by the Aragón Engineering Research Institute (I3A), the SAMCA Chair of Technological Development, CEOE-Aragón and the Zaragoza Chamber. On this occasion, it will be held online and it[...]

		
		
	

											

											U9-Synthesis of Nanoparticles Unit											

												
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U10. Drug Formulation

												

		
		

		
		
	

		
		
Ciber bbn


U10. Drug Formulation


    

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    • Scientific Director: Prof. José Luis Pedraz joseluis.pedraz@ehu.es
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    • Scientific Coordinator: Dr. Idoia Gallego Garrido idoiagallego@hotmail.com
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    • Entities: Universidad del País Vasco (UPV/EHU)
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    • Address: Pharmacy & Pharmac. Technology Lab.; Facultad de Farmacia, C/Paseo de la Universidad 7, 01006 Vitoria-Gasteiz (Spain)
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    • Phone: +34 653593042
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    • Fax: +34 945 013040
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    • Web: NANOBIOCEL UPV/EHU
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UPV-EHU






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U10. Drug Formulation-Particle_size_analyzerU10. Drug Formulation-Particle_size_analyzer
U10. Drug Formulation-LOTE 4 CALCEINA 10X 2BISU10. Drug Formulation-LOTE 4 CALCEINA 10X 2BIS
U10. Drug Formulation- Dissolution_rate_determination_equipmentU10. Drug Formulation- Dissolution_rate_determination_equipment


Description


Located at the Faculty of Pharmacy, University of the Basque Country (UPV/EHU), Campus of Alava in Vitoria. The Unit is led by Prof. José Luis Pedraz and consists of large laboratories for: cell culture, chromatography equipment, sample preparation and characterization and one specific for scale preparation of pharmaceutical formulations. Recently the group has incorporated 3D bioprinters of last generation with different technologies based on extrusion, ink jet, among others. It has also incorporated a self-assembly equipment of nanoparticles based on microfluidic technologies.


This Unit has the capacity to design and evaluate dosage forms both classical and new dosage forms of biotech drugs, DNA, RNA and vaccines using different methodologies based on micro and nano-medicine and the latter technology based on the microencapsulation of cells, peptides, proteins, and in general of biotech products, as well as the development and design of non-viral vectors for gene therapy, is one of the biggest singularities of this Unit. It counts with the most advanced equipment for micro and nano encapsulation.


The aim of the Unit is to determine experimentally all the variables needed to develop an optimal formulation and work instructions for preparing final pharmaceutical products.


The pharmaceutical technology applied to drug development involves the selection of materials and procedures that can be adapted to different processes that lead to specific pharmaceutical forms. To do that, the Unit10 counts with the most advanced equipment to cover the development for all the steps of the process.


One of the singularities of this Units is that is GLP certified by the Spanish Medicament Agency 



		
Services

		

			



FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE



		
U10. Services & Rates

		
Equipments

		

			




		

		
		
	

		
		

		
Active projects

		

			


	






Title
Fundin: Organism
Call: Funding source 
Role







RTC-2016-4770-1

Development of a new bioadhesive for the treatment of Pterigium. Biotape


Ministerio de Economía, Industría y Competitividad (MINECO)
Retos Colaboración 2016
Partner




RTC-2016-5451-1

Development of Bioprinting and Bioink systems for cartilage and bone repair


Ministerio de Economía, Industria y Competitividad (MINECO)
Retos Colaboración 2016
Partner




GA: 783132

POSITION-II “A pilot line for the next generation of smart catheters and implants”


Electronic Component Systems for European Leadership Joint Undertaking (JU) - ECSEL JU
H2020-ECSEL-2017-1-IA-two-stage
Partner




GA: 645991

DRIVE – Diabetes-Reversing Implants for Enhanced viability and long-term efficacy
Unión Europea (Comisión Europea)
H2020-NMP-2014-two-stage
Partner




SAF2017-90810-REDI

Strategic Promotion and coordinated management of Nanbiosis: Pronanbiosis II
Agencia Estatal de Investigación (AEI)
Acciones de dinamización  «REDES DE EXCELENCIA»

-ICTS 2017		
Coordinator







		

		
Other projects

		

			


	




Ref
Title
Funding Organism
Unit Role







RTC-2016-4770-1
DEVELOPMENT OF A NEW BIOADHESIVE FOR PTERIGIUM SURGERY. BIOTAPE
MINISTERIO DE ECONOMIA, INDUSTRIA Y COMPETITIVIDAD.
Participant




RTC-2016-5451-1
DEVELOPMENT OF BIOIMPRESSION SYSTEMS AND BIOTINES FOR THREE-DIMENSIONAL CARTILAGE AND BONE REGENERATION
MINISTERIO DE ECONOMIA, INDUSTRIA Y COMPETITIVIDAD.
Participant




RTC-2015-3303-1
Lipid solid nanoparticles for subcutaneous administration of antitumor marine compounds - UNDERLIPIDS
MINISTERIO DE ECONOMIA Y COMPETITIVIDAD








		

		
Publications

		

			2016


    

  • Grijalvo S., Puras G., Zarate J., Pons R., Pedraz J.L., Eritja R. et al. Nioplexes encapsulated in supramolecular hybrid biohydrogels as versatile delivery platforms for nucleic acids. RSC Advances. 2016;6(46):39688-39699.
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  • Moreno-Sastre M., Pastor M., Esquisabel A., Sans E., Vinas M., Fleischer A. et al. Pulmonary delivery of tobramycin-loaded nanostructured lipid carriers for Pseudomonas aeruginosa infections associated with cystic fibrosis. International Journal of Pharmaceutics. 2016;498(1-2):263-273.
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  • Moreno-Sastre M., Pastor M., Esquisabel A., Sans E., Vinas M., Bachiller D. et al. Stability study of sodium colistimethate-loaded lipid nanoparticles. Journal of Microencapsulation. 2016;33(7):636-645.
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  • Garcia-Orue I., Gainza G., Gutierrez F.B., Aguirre J.J., Evora C., Pedraz J.L. et al. Novel nanofibrous dressings containing rhEGF and Aloe vera for wound healing applications. International Journal of Pharmaceutics. 2016;:-.
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  • Ojeda E., Puras G., Agirre M., Zarate J., Grijalvo S., Eritja R. et al. The role of helper lipids in the intracellular disposition and transfection efficiency of niosome formulations for gene delivery to retinal pigment epithelial cells. International Journal of Pharmaceutics. 2016;503(1-2):115-126.
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  • Ojeda E., Puras G., Agirre M., Zarate J., Grijalvo S., Eritja R. et al. The influence of the polar head-group of synthetic cationic lipids on the transfection efficiency mediated by niosomes in rat retina and brain. Biomaterials. 2016;77:267-279.
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News U10
29 Apr
CRISPR technologies for Cystic Fibrosis treatment
Cystic fibrosis is an inherited genetic disease that mainly affects the lungs and the digestive system On April 6, the first meeting was held, on the one hand, with people with Cystic Fibrosis and the Euskadi Cystic Fibrosis Association (Arnasa) and, on the other, with the NanoBioCel research group of the CIBER-BBN and the University [...]
05 Apr
1st Meeting with Cystic Fibrosis Patiens (NanoBioCel -ARNASA)
Cystic Fibrosis is a genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. It is a genetic, degenerative and chronic disease, with a population incidence is 1 in 5,000, so it is considered among the so called “Rare Diseases” The most common symptoms are continuous colds, repeated infections, decreased lung capacity, impossibility of fat absorption and [...]
22 Mar
The results of POSITION II highlighted by CORDIS: A pan-European alliance for the next generation of smart catheters
In the picture: microencapsulated cardiospheres 10X Captured Brightfield with DM_RGB_Brightfield with DM The European project POSITION-II has been selected for publication in the ‘Results in Brief’ section of the Community Research and Development Information Service (CORDIS) website. CORDIS is the European Commission’s primary source of results from the projects funded by the EU’s framework programmes [...]
15 Feb
AWARDS of the Academy of Pharmacy of Castilla y León 2021 to  researchers from NANBIOSIS U10
The leader of the NanoBioCell Group form CIBER-BBN and UPV/EHU, Jose Luis Pedraz, and the reaearches Laura Saenz del Burgo and Markel Lafuente have received the 2021 Award from the Academy of Pharmacy of Castilla y León, on February 4, at the city ​​of Salamanca, for the work entitled: “Design and Characterization of a biotin [...]
13 Jan
Best Emergeging Researcher Award  in the Biomedical Area to Edorta Santos
Edorta Santos Vizcaíno has been awarded as Best Emerging Researcher in the biomedical area by the Bioaraba Health Research Institute in the XXII edition of the Research and Innovation Conference. This award aims to recognize the work of researchers under the age of 40 who carry out their research activity in any public center of [...]
26 Nov
New Equipment available for the Regenerative Medicine Research Line of the U10 of NANBIOSIS
The Unit 10 of Drug Formulation of the ICTS NANBIOSIS coordinated by the CIBER-BBN NanoBioCel group directed by Jose Luis Pedraz, which belongs to the University of the Basque Country, has been present at the signing of the agreement that gives support by the Provincial Council of Alava within the framework of the Advance Pharma [...]
14 Oct
Results of the POSITION-II Project “A pilot line for the next generation of smart catheters and implants”
Cáceres, October 14th, 2021 POSITION II has received funding within the Electronic Components and Systems for European Leadership Joint Undertaking (ECSEL JU) in collaboration with the European Union’s H2020 Framework Programme (H2020/2014-2020) and National Authorities, under grant agreement Ecsel-783132-Position-II-2017-IA. It promotes innovation in smart medical instruments and focuses in the next generation of smart catheters [...]
30 Sep
Scientific Communication course
We want to invite you to a practical and short course of Introduction to Scientific Communication organized by CIBER-BBN and NanoBioCellGroup – NANBIOSIS U10 Drug Formulation Unit. The course will take place on the 5th (two hours from 9:00 am to 11:00 am) 6 and October 7 (4 hours from 9:00 a.m. to 1:00 p.m.) [...]
27 Jul
Characterization of encapsulated porcine cardiosphere-derived cells for cardiac regeneration.
Researchers of NANBIOSIS U10 Drug Formulation unit of CIBER-BBN and UPV/EHU and NANBIOSIS U14 Cell Therapy unit and U24 Medical imaging unit at CCMIJU have participated in a research that proposes the use of encapsulated cardiosphere-derived cells (CDC), obtained from heart tissue, as regenerative cell therapy. “The encapsulation of the cells has been carried out [...]
04 Mar
Reversing pulmonary fibrosis has been achieved  in murine models with peptide-loaded nanoparticles
A new study with participation of NANBIOSIS Unit 10 Drug Formulation unit of CIBER-BBN and UPV/EHU, has succeeded in preventing and reversing pulmonary fibrosis in experimental models with PLGA / PEI nanoparticles loaded with the GSE4 peptide. These results are the first step to study its possible antifibrotic effect in patients with idiopathic pulmonary fibrosis [...]

		
		
	

											

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U12. Nanostructured liquid characterization unit

												

		
		

		
		
	

		
		
Ciber bbn


U12. Nanostructured liquid characterization unit


    

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    • Scientific Director: Prof. Carlos Rodríguez cranqb@cid.csic.es
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    • Scientific Coordinator: Jordi Esquena jemqci@iqac.csic.es
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    • Entities: Colloid and Interfacial Chemistry Group (QCI) at the Institute of Advanced Chemistry of Catalonia (IQAC) & Consejo Superior de Investigaciones Científicas (CSIC)
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    • Address: Jordi Girona, 18-26, 088034, Barcelona, Spain
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    • Phone: +34 934 006 159
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    • Web: QCI – IQAC- CSIC
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IQAC
CSIC








Order request

		
		
	

		
		
U.12 – Reometro_2U.12 – Reometro_2
U.12 – tensiometro_2U.12 – tensiometro_2
U.12 – Espectrofotometro_2U.12 – Espectrofotometro_2


Description


The unit is located at the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), in Barcelona and it is coordinated by the Colloidal and Interfacial Chemistry Group, led by Dr. Carlos Rodríguez. The unit is focused on the characterization of nanostructures in liquids and liquid/liquid interfaces, such as micelles, liposomes, micro- and nano-emulsions, and nanoparticles. The unit features state-of-the-art instrumentation for the determination of various parameters such as size distribution and zeta potential (surface charge), critical micelle concentration (CMC), solubilization capacity, osmolarity, surface and interfacial tension, wettability, refractive index, turbidity, colloidal stability, density, viscosity and other rheological parameters (shear and elastic moduli, critical yield stress, etc.)


The Unit 12 has implemented and mantein the ISO9001 certification forstandard quality control system.


 IQNet ISO 9001:2015 Certification 


 AENOR ISO 9001:2015 Certification 



		
Services

		

			



 


FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE 
		
U12. Services & Rates

		
Equipments

		

			




		

		
		
	

		
		

		
Active projects

		

			


	






Title
Fundin: Organism
Call: Funding source 
Role







SAF2017-90810-REDI

Strategic Promotion and coordinated management of Nanbiosis: Pronanbiosis II
Agencia Estatal de Investigación (AEI)
Acciones de dinamización «REDES DE EXCELENCIA» -ICTS 2017
Partner




PICCOLO-732111

Multimodal highly-sensitive PhotonICs endoscope for improve in vivo COLOn Cancer diagnosis and clinical decision support
European Commission-H2020
H2020-ICT-2016-1
Partner




0624_2IQBIONEURO_6_E

Promotion of an R&I network in biological chemistry for the diagnosis and treatment of neurological diseases
European Union Interreg : European Territorial Co-operation
POCTEP Interreg España-Portugal
Partner







		

		
Other projects

		

			


	




Ref
Title
Funding Organism
Unit Role







CTQ2014-52687-C3-1-P
Design and applications of new biocompatible micro / nanogels obtained by advanced condensation methods (MICRONANOGELES)
MINECO
Participant




2014SGR1655
Grants for consolidated Research Groups of Catalonia
Generalitat de Catalunya
Participant




FP7-PEOPLE-2013-ITN - 606713
Biopolymer Based FOOd Delivery Systems (BIBAFOODS)
Unión Europea
Participant




Plan de Actuación 2015
Agreement of ACC1Ó with the UAB, the PRUAB, the CSIC and the CVC for the promotion of the technological transfer
Generalitat de Catalunya
Participant




TECSPR14-2-0033 
Theranostic Magnetic Nanoparticles For Cancer Diagnosis and Treatment: Magnetic Properties and Controlled Release of Anticancer Drugs (TheraMagNano)
Unión Europea
Participant




TECSPR14-2-0044
Novel antimicrobial hydrogels for contact lenses (HYDROLENSES)
Unión Europea
Participant




Acción COST CM1101
Joint Meeting of WG 3 and WG 4. Workshop "Nano-biocolloidal materials and non-equilibrium self-assembly"
Unión europea
Participant




Ref.: 308810 076/2015 
DEVELOPMENT OF INNOVATIVE FORMULATIONS FOR THE DELIVERY OF ACTIVITIES INTO THE SKIN (ES)
ALMIRALL
Participant







		

		
Publications

		

			2016


    

  • Fornaguera C., Caldero G., Solans C.. Electrolytes as a tuning parameter to control nano-emulsion and nanoparticle size. RSC Advances. 2016;6(63):58203-58211.
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  • Caldero G., Montes R., Llinas M., Garcia-Celma M.J., Porras M., Solans C.. Studies on the formation of polymeric nano-emulsions obtained via low-energy emulsification and their use as templates for drug delivery nanoparticle dispersions. Colloids and Surfaces B: Biointerfaces. 2016;145:922-931.
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  • Fornaguera C., Feiner-Gracia N., Caldero G., Garcia-Celma M.J., Solans C.. PLGA nanoparticles from nano-emulsion templating as imaging agents: Versatile technology to obtain nanoparticles loaded with fluorescent dyes. Colloids and Surfaces B: Biointerfaces. 2016;147:201-209.
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  • Magana J.R., Kolen’Ko Y.V., Deepak F.L., Solans C., Shrestha R.G., Hill J.P. et al. From Chromonic Self-Assembly to Hollow Carbon Nanofibers: Efficient Materials in Supercapacitor and Vapor-Sensing Applications. ACS Applied Materials and Interfaces. 2016;8(45):31231-31238.
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  • Perez-Carrillo L.A., Vilchez S., Mosa J., Aparicio M., Castro Y., Duran A. et al. Synthesis and properties of TiO2-P2O5 and SiO2-TiO2-P2O5 porous hybrids obtained by templating in highly concentrated emulsions. Ceramics International. 2016;42(16):18965-18973.
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News U12
03 May
OPEN SUBMISSION FOR JOURNAL SPECIAL ISSUE ON OLIGONUCLEOTIDE BASED THERAPIES
Dr. Ramon Eritja, Scientific Director of NANBIOSIS unit 29 of Oligonucleotide Synthesis Platform (OSP) and Dr. Santiago Grijalvo researcher at NANBIOSIS unit 12 of Nanostructured liquid characterization, from CIBER-BBN and IQAC-CSIC, together with Dr. Andreia F. Jorge, from Coimbra Chemistry Centre (CQC), acting as guest editors of journal Pharmaceutics, of MDPI Publisher, welcome authors to submit their articles on special issues on Recent Trends in Oligonucleotide Based Therapies. In the past few decades, significant efforts have been made towards the clinical application of oligonucleotides. However, the potential of the therapeutic applications of RNA-based strategies have recently been spotlighted after the first approval of mRNA vaccines in response to COVID-19[...]
02 May
Wide representation of NANBIOSIS research in NALS 2022 and best Oral Presentation to Eloi Parladé
During the last 27-29 April, the 3rd International Conference on Nanomaterials Applied to Life Sciences 2022 (NALS 2022) has taken place in the Excellence Campus of Universidad de Cantabria in Santander (Spain), organized by the University of Cantabria and Institute Valdecilla-IDIVAL. NALS 2022 has been a multidisciplinary conference series sharing new results and ideas in the fields of biosensors, lab on a chip, drug delivery nanopharmacy. nanobiotechnology, intelligent nanomaterials, magnetic materials, nanotoxicity, antimicrobials, novel applications of 3d bioprinting and nanoimaging. NANBIOSIS has been represented at this edition by members of several of its units, among them we must highlight the set of four ora[...]
31 Mar
Colloidal phenomena in COVID-19
Transmission electron microscope image of SARS-CoV-2 (National Institute of Allergy and Infectious Diseases https://www.niaid.nih.gov) The special volume (No. 55) of the journal Current Opinion in Colloid and Interface Science reviews the implications of colloidal science in the phenomenology of COVID-19, for which the techniques available in NANBIOSIS U12, “Nanostructured liquid characterization unit” , are relevant. Two articles to highlight in this special volume: Airborne transmission of the virus through droplets, and the effect of evaporation and sedimentation. Airborne transmission is determined by the settling time, that is, the time it takes for droplets to be in the air before settling.[...]
18 Oct
ISO 9001-2015 Quallity Management Certification  for NANBIOSIS U12
NANBIOSIS U12 “Nanostructured liquid characterization unit” of IQAC-CSIC and CIBER-BBN, led by Dr. Carlos Rodriguez Abreu and D. Jordi Esquena, has implemented a Quality Management System for the scope of Technological service for characterization of colloidal dispersions, which fulfills the requirements of the standard ISO 9001:2015. An IQNet recognized certificate has been issued by AENOR last week. This certification will expand and consolidate the service  that Unit 12 of NANBIOSIS is giving to companies and public sector researchers and facilitate their integration in cooperative international projects. The ISO 9001 Standard is the most widespread Quality Management tool worldwide, with over[...]
20 Sep
The European Researcher’s Night with NANBIOSIS’ scientists.
The European Researchers’s Nigth is a public event dedicated to the dissemination of science that is held every year in more than 300 cities in 30 countries of Europe at the same time, organized on the last Friday and Saturday of September. This year face-to-face activities are progrmmed in different locations of Catalonian cities and also the “Nit de la Recerca” YouTube channel offers more than 20 noves microxerrades led by researchers from Catalonia. Two NANBIOSIS’ researchers have joined this event to explain their research: Julian Guercetti – Nb4D Group – NANBIOSIS U2 CAbS, from IQAC-CSIC and CIBER-BBN, will giv[...]
05 May
Practical Sessions in the Master of Cosmetic and  Dermopharmacy by NANBIOSIS U12
The researchers of NANBIOSIS U12, Nanostructured liquid characterization unit of CIBR-BBN and IQAC-CSIC, will participate in teaching and training students of the Master en Cosmética y Dermofarmacia, organized by Centro de Estudios Superiores de la Industria Farmacéutica (CESIF), from 17 May to 16 June 2021. Cosmetic manufacturing companies are committed to innovation, both in technological development and in the use of components in their formulations, adapting to new trends and user needs. Determination of colloidal stability, surface tension, particle size and rheological behaviour, among many others properties, is essential for the proper characterization and understanding the performance of cosmetic products.[...]
18 Feb
Gels formed from the interaction of lipid vesicles: Influence  of charge in their structural and rheological properties
Susana Vilchez, researcher at NANBIOSIS U12. Nanostructured liquid characterization unit  of CIBER-BBN and IQAC-CSIC, is coauthor of an article recently published in the Journal of Molecular Liquids. “This work – explains Susana Vilchez – shows how structural and viscoelastic properties of a lipid colloidal gel can be altered by varying the ratio of charged lipids in the dispersion. These findings corroborate that the eventual formation of the gel and the morphology of its network is governed by the repulsive potential of the particles instead of the molecular composition of their membranes. Thus, the right control of charge balance in the system may[...]
28 Jan
Encapsulation of BSA/alginate water–in–water emulsions by polyelectrolyte complexation
Researchers of NANBIOSIS U12. Nanostructured liquid characterization unit from CIBER-BBN and IQAC-CSIC have recently published an article entitled Encapsulation of BSA/alginate water–in–water emulsions by polyelectrolyte complexation in the scientific journal Food Hydrocolloids The research which results are published involves the encapsulation of drops of water-in-water emulsions, which could be used as vehicles for the administration of active principles. Characterization of emulsions and capsules was performed in the Unit 12 of NANBIOSIS Nanostructured Liquid Characterization Unit. Water-in-Water (W/W) emulsions were prepared in aqueous mixtures of an anionic polyelectrolyte (sodium alginate, NaAlg), with a globular protein (bovine serum albumin, BSA). This combination showed phase separation[...]

		
		
	

											

											U12-Nanostructured liquid characterization unit											

												
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