U6. Biomaterial Processing and Nanostructuring Unit
- U6-S01. Use of High-pressure laboratory-scale plant with 50, 100 and 300 m reactors for the processing of biomaterials. Processing of cytotoxic compounds when required. (Remote) OUTSTANDING
- U6-S02. High-pressure phase analysis – solubility, emulsification (Remote) OUTSTANDING
- U6-S03. Thermal analysis of solid materials(Remote) OUTSTANDING
- U6-S04. Analysis of particle size, concentration and Z-potential of nanoparticles (On-site&Remote) OUTSTANDING
- U6-S05. Analysis of particle morphology (Remote) OUTSTANDING
- U6-S06. Fluorescence spectroscopic analysis (On-site&Remote)
- U6-S07. UV-Vis spectroscopic analysis (On-site&Remote)
- U6-S08. Visual observation (On-site&Remote)
- U6-S09. Centrifugation (On-site)
- U6-S10. Treatment of sample by ultrasound probe (On-site)
- U6-S11. Specific density of powders (On-site&Remote) OUTSTANDING
- U6-S12. Packed (tapped) density(On-site) OUTSTANDING
- U6-S13. Detection of labeled nanoparticles and exosomes by fluorescence mode (On-site&Remote) OUTSTANDING
- U6-S14. Quantitative studies of biomolecular interactions by calorimetric measurements (On-site) OUTSTANDING
FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE
- U6-E01. High-pressure laboratory-scale plant with 50, 100 and 300 ml reactors for the processing of biomaterials.
- U6-E02. High-pressure phase analyzer for studying the thermodynamic behaviour of materials.
- U6-E03. Malvern Zetasizer Nano ZS particle size analyzer.
- U6-E04. Nanosight LM -20 for Nanoparticle Tracking Analysis.
- U6-E05. Nanosight NS-300 for Nanoparticle Tracking Analysis by fluorescence mode.
- U6-E06. Perkin-Elmer DSC 8500 differential scanning calorimeter.
- U6-E07. Olympus BX51 optical microscope with heating plate and fluorescence accessories.
- U6-E08. Perkin-Elmer LS 45 fluorescence spectrometer.
- U6-E09. Varian Cary 5 UV -Vis spectrometer.
- U6-E10. Quantachrome Ultrapyc 1200e helium pycnometer.
- U6-E11. Ultrasound probe and Autotap instrument for packed density measurements of powders.
- U6-E12. Malvern Morphologi G3 for advanced particle morphologi characterization.
- U6-E13. Microcalorimeter for measurements of biomolecular binding properties under Isothermal Titration Calorimetry (ITC)
- U6-E14. Four Glove Dispensing isolator for expermiments with highly active and cytotoxic compounds
|Title||Fundin: Organism||Call: Funding source||Role|
|GA: 720942||SMART FUNCTIONAL GLA-NANOFORMULATION FOR FABRY DISEASE – Smart-4-Fabry||Unión Europea (Comisión Europea)||H2020-NMBP-2016-2017||Coordinator|
|SAF2017-90810-REDI||Strategic Promotion and coordinated management of Nanbiosis: Pronanbiosis II||Agencia Estatal de Investigación (AEI)||Acciones de dinamización «REDES DE EXCELENCIA» -ICTS 2017||Coordinator|
|Ref||Title||Funding Organism||Unit Role|
|PI15/00272||Design of intelligent nanoconjugates for the treatment of metastatic colorectal cancer.||Instituto de Salud Carlos III||Participant|
|H2020-MSCA-ITN-2014-642196||Integrated self-assembled SWITCHable systems and materials: towards responsive organic electronics - a multi-site innovative training action i-Switch||Unión Europea H2020||Participant|
|2014 SGR 17||Consolidation Research Group: Molecular Nanociènciai Materials Orgànics (NANOMOL)||Generalitat de Catalunya||Participant|
|CTQ2013-40480-R||Molecular Bio- and Electro-active materials for the improvement of health and social well-being (Be-Well)||MICINN||Participant|
|FP7-PEOPLE-2013-ITN nº 607721||Nanochemistry of molecular materials for 2-photon functional applications. Nano2Fun||Unión Europea||Participant|
|MAT2013-50036-EXP||Cell Surface Vessel Engineering Using Dynamic Molecular Bioinfecting (DYNAMO)||MINECO||Participant|
|RTC-2016-4567-1||Nanocapsules containing active ingredients for the topical treatment of dermatological diseases (NANO4DERM)||MINECO||Participant|
|RTC-2014-2183-S||Application of Quatsomes technology for the development of a new range of perfumed softeners with lower environmental impact||MINECO||Participant|
|201260E080||Self-assembly, Nanostructuring and Processing of Functional Organic Molecules and their Applications||Ministerio de Ciencia e Innovación||Participant|
|MAT2016-80826-R||Molecular materials and supramolecular organizations for therapy, diagnosis and tissue engineering (MOTHER)||MINECO||Participant|
|RTC-2014-2207-1||TERARMET: Development of therapies for the treatment of rare congenital metabolic diseases||MINECO||Participant|
- Munoz-Gomez J.L., Monteagudo E., Lloveras V., Parella T., Veciana J., Vidal-Gancedo J.. Optimized polarization build-up times in dissolution DNP-NMR using a benzyl amino derivative of BDPA. RSC Advances. 2016;6(32):27077-27082.
- Cordoba A., Hierro-Oliva M., Pacha-Olivenza M.A., Fernandez-Calderon M.C., Perello J., Isern B. et al. Direct Covalent Grafting of Phytate to Titanium Surfaces through Ti-O-P Bonding Shows Bone Stimulating Surface Properties and Decreased Bacterial Adhesion. ACS Applied Materials and Interfaces. 2016;8(18):11326-11335.
- Cabrera I., Abasolo I., Corchero J.L., Elizondo E., Gil P.R., Moreno E. et al. α-Galactosidase-A Loaded-Nanoliposomes with Enhanced Enzymatic Activity and Intracellular Penetration. Advanced Healthcare Materials. 2016;5(7):829-840.
- Cano-Garrido O., Sanchez-Chardi A., Pares S., Giro I., Tatkiewicz W.I., Ferrer-Miralles N. et al. Functional protein-based nanomaterial produced in microorganisms recognized as safe: A new platform for biotechnology. Acta Biomaterialia. 2016;43:230-239.
Twenty years ago, the 4 February was declared World Cancer Day with the global challenge of cancer would not be forgotten. Since then, huge progress has been made to understand, prevent, diagnose, and treat cancer. NANBIOSIS as an ICTS (Singular Scientific and Technical infrastructures) for biomedical research plays a very important role in the fight against cancer. Some examples of the work carried out during the last year, are bellow: Unit 20 of NANBIOSIS at VHIR, works in several proyects reletaed to cancer as H2020-NoCanTher: magnetic nanoparticles against pancreatic cancer through the use of hyperthermia combined with conventional treatment. H2020-Target-4-Cancer: nanotherapy based on polymeric micelles directed against[...]
Researchers of CIBER-BBN and NANBIOSIS-ICTS (U6 Biomaterial Processing and Nanostructuring Unit at ICMAB-CSIC and U18 Nanotoxicology Unit at Hospital de la Santa Creu i Sant Pau have developed a new nanocarrier for bio-imaging and drug-delivery applications The new nanovesicle formulation is based on the quatsome architecture – which stands out due to the high colloidal stability and homogeneity in size – and has now been shown to be suitable for in vivo dosing. Quatsomes are new non-liposomal lipid-based nanovesicles that have been developed by Nanomol group in recent years, and have been shown to be highly homogeneous and stable in[...]
Researchers of NANBIOSIS U6. Biomaterial Processing and Nanostructuring Unit have just published the article titled “An enantiopure propeller ‐ like trityl ‐ brominated radical: Bringing together a high racemization barrier and an efficient circularly polarized luminescent magnetic emitter” in the scientific magazine Chemistry A European Journal. The urgent need to cope with the more and more specific requirements in electronic devices is nowadays behind the search for new multifunctional materials. In this work, a step forward has been done in the field of organic free radicals acting as chiral emitters. The recently developed brominated trityl derivative, namely TTBrM radical, shows[...]
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Cell-selective targeting is expected to enhance effectiveness and minimize side effects of cytotoxic agents. Functionalization of drugs or drug nanoconjugates with specific cell ligands allows receptor-mediated selective cell delivery. However, it is unclear whether the incorporation of an efficient ligand into a drug vehicle is sufficient to ensure proper biodistribution upon systemic administration, and also at which extent biophysical properties of the vehicle may contribute to the accumulation in target tissues during active targeting. To approach this issue, structural robustness of self-assembling, protein-only nanoparticles targeted to the tumoral marker CXCR4 is compromised by reducing the number of histidine residues (from[...]
Amable Bernabé, Technical Coordinator of NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit has given a course from Monday, 7 October, to Wednesday, 9 October on “Characterization techniques for particulate materials”. The course has counted with 12 participants from different CSIC centers (including ICMAB, IBM-CNM, ICM, IQAC…) and has introduced the participants to different techniques to characterize nanoparticles and other particulate matter, including the basic fundamentals, sample preparation, practical examples and results interpretation. It is the second time that Amable Bernabé, technician from the Sof tLab, has decided to offer this course to all the CSIC community, so they can learn new methods to characterize nanoparticles,[...]
Jaume Veciana, Scientific Director of NANBIOSIS is coauthor of an article chosen to be highlighted on the ChemistryViews newsletter: “Organic Free Radicals as Circularly Polarized Luminescence Emitters”, published in Angewandte Chemie International Edition, and is about the intrinsic chiral emission of enantiometric organic free radicals. The short news about the paper is entitled “Circulary Polarized Light from Organic Radicals” is available here. Circularly polarized luminescence (CPL) can occur when a luminescent compound has a chiral structure. Organometallic structures are leading in CPL activity. However, purely organic CPL emitters are promising alternatives in several applications where low toxicity is important (i.e., bioimaging). Jaume Veciana (Institut de Ciéncia de Materials de Barcelona (ICMAB), Spain), Araceli G. Campaña (University of Granada, Spain)[...]
Sara Larriba of the Human Molecular Genetics Group of Bellvitge Biomedical Research Institute (IDIBELL) has informed NANBIOSIS about a recent publication mentioning NANBIOSIS in the Acknowledgements for its participation in the results of their research. (The nanoparticle tracking analysis was performed by the ICTS NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit) The article has been published by the journal Scientific Reports of Nature Research. The prediction of PCa in the early stage of the disease is one of the most important objectives in male urology. A significant decrease in deaths due to PCa has been associated with the use of serum[...]