encapsulation - Nanbiosis

U6. Biomaterial Processing and Nanostructuring Unit

U6. Biomaterial Processing and Nanostructuring Unit

- Scientific Director: Dr. Mariana Köber mkober@icmab.es
- Scientific Coordinator: Dr. Elisabet González Mira egonzalez@icmab.es
- Technical Coordinator: José Amable Bernabé jabernabe@icmab.es
- Entities: Instituto de Ciencia de Materiales de Barcelona ICMAB-CSIC
- Address: Campus de UAB, 08193, Bellaterra, Barcelona, Spain
- Phone: +34 935 801 853
- Fax: +34 935 805 729
- Web: ICMAB

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Description

Located at the Instituto de Ciencia de Materiales de Barcelona (ICMAB-CSIC), in Barcelona, and under the coordination of Prof. Nora Ventosa, current director of NANOMOL Group, which is a research group with wide expertise and recognized excellence in the synthesis, processing, and study of molecular and polymeric materials with chemical, electronic, magnetic and biomedical properties. It gathers several laboratories, perfectly equipped, to perform the mission of this facility: the development, characterization, and large-scale production of molecular biomaterials of therapeutic or biomedical interest, with controlled micro-, nano-, and supramolecular structure. One example of Key-Enabling-Technology (KET) available in this unit is a simple one-step methodology, DELOS-SUSP, based on the use of compressed fluids (CF), such as CO2, to prepare particulate materials with precise and reproducible structural characteristics at micro-, nano- and supramolecular levels (size, shape, internal structural gradients, supramolecular organization, and crystalline purity). This example shows one of the singularities of this unit: that it counts with CF–based plants at different scales, from mL to L, which allows process development by QbD and process scale-up.

The NANBIOSIS Unit 6 works under the ISO9001 certification for standard quality control system

QUALITY COMMITMENT

QUALITY POLICY

UNE-EN ISO 9001:2015 CERTIFICATION

Services

FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE

U6. Services & Rates

Equipments

Active projects

		Title	Fundin: Organism	Call: Funding source	Role
GA: 720942		SMART FUNCTIONAL GLA-NANOFORMULATION FOR FABRY DISEASE – Smart-4-Fabry	Unión Europea (Comisión Europea)	H2020-NMBP-2016-2017	Coordinator
SAF2017-90810-REDI		Strategic Promotion and coordinated management of Nanbiosis: Pronanbiosis II	Agencia Estatal de Investigación (AEI)	Acciones de dinamización «REDES DE EXCELENCIA» -ICTS 2017	Coordinator

Other projects

Ref	Title	Funding Organism	Unit Role
PI15/00272	Design of intelligent nanoconjugates for the treatment of metastatic colorectal cancer.	Instituto de Salud Carlos III	Participant
H2020-MSCA-ITN-2014-642196	Integrated self-assembled SWITCHable systems and materials: towards responsive organic electronics - a multi-site innovative training action i-Switch	Unión Europea H2020	Participant
2014 SGR 17	Consolidation Research Group: Molecular Nanociènciai Materials Orgànics (NANOMOL)	Generalitat de Catalunya	Participant
CTQ2013-40480-R	Molecular Bio- and Electro-active materials for the improvement of health and social well-being (Be-Well)	MICINN	Participant
FP7-PEOPLE-2013-ITN nº 607721	Nanochemistry of molecular materials for 2-photon functional applications. Nano2Fun	Unión Europea	Participant
MAT2013-50036-EXP	Cell Surface Vessel Engineering Using Dynamic Molecular Bioinfecting (DYNAMO)	MINECO	Participant
RTC-2016-4567-1	Nanocapsules containing active ingredients for the topical treatment of dermatological diseases (NANO4DERM)	MINECO	Participant
RTC-2014-2183-S	Application of Quatsomes technology for the development of a new range of perfumed softeners with lower environmental impact	MINECO	Participant
201260E080	Self-assembly, Nanostructuring and Processing of Functional Organic Molecules and their Applications	Ministerio de Ciencia e Innovación	Participant
MAT2016-80826-R	Molecular materials and supramolecular organizations for therapy, diagnosis and tissue engineering (MOTHER)	MINECO	Participant
RTC-2014-2207-1	TERARMET: Development of therapies for the treatment of rare congenital metabolic diseases	MINECO	Participant

Publications

2016

Munoz-Gomez J.L., Monteagudo E., Lloveras V., Parella T., Veciana J., Vidal-Gancedo J.. Optimized polarization build-up times in dissolution DNP-NMR using a benzyl amino derivative of BDPA. RSC Advances. 2016;6(32):27077-27082.
Cordoba A., Hierro-Oliva M., Pacha-Olivenza M.A., Fernandez-Calderon M.C., Perello J., Isern B. et al. Direct Covalent Grafting of Phytate to Titanium Surfaces through Ti-O-P Bonding Shows Bone Stimulating Surface Properties and Decreased Bacterial Adhesion. ACS Applied Materials and Interfaces. 2016;8(18):11326-11335.
Cabrera I., Abasolo I., Corchero J.L., Elizondo E., Gil P.R., Moreno E. et al. α-Galactosidase-A Loaded-Nanoliposomes with Enhanced Enzymatic Activity and Intracellular Penetration. Advanced Healthcare Materials. 2016;5(7):829-840.
Cano-Garrido O., Sanchez-Chardi A., Pares S., Giro I., Tatkiewicz W.I., Ferrer-Miralles N. et al. Functional protein-based nanomaterial produced in microorganisms recognized as safe: A new platform for biotechnology. Acta Biomaterialia. 2016;43:230-239.

News U6

28 Mar

New hands-on material characterization seminar by NANBIOSIS experts and NANE

Technical Seminar on Materials Characterization by NANBIOSIS Unit 6 & NANE on April 1, 2025, at ICMAB-CSIC. Hands-on training & latest techniques. Register now! Barcelona, march 2025. The Soft Materials Lab – NANBIOSIS Unit 6, in collaboration with NANE, is pleased to invite researchers, professionals, and students to a Technical Seminar on Materials Characterization. The event will take place on Tuesday, April 1st, 2025, from 9:30 AM to 5:00 PM at the Institute of Materials Science of Barcelona (ICMAB-CSIC). This seminar will provide attendees with an opportunity to explore the latest advancements in particle size analysis techniques and gain hands-on[...]

25 Mar

New breakthrough in preventing infections in biomedical implants

A new TPU surface modification with an antimicrobial protein prevents biofilm formation in implants, offering an alternative to antibiotics and metal coatings. Barcelona, february 2025. Infections associated with medical implants are a serious health issue. A new study presents a chemical modification of thermoplastic polyurethane (TPU) with an antimicrobial protein that reduces the formation of biofilms of multidrug-resistant bacteria, offering an alternative to antibiotics and metal coatings in these devices. A team of researchers has developed a new strategy to chemically modify TPU, a material widely used in medical devices, to endow it with antibacterial properties and prevent infections associated[...]

28 Feb

Awareness and research on Fabry Disease with a special event at ICMAB

Join us on April 29 at ICMAB for “Fabry Connections” to explore research, patient insights, and future challenges in Fabry disease. Register now! Barcelona, february 2025. Today, February 28, World Rare Disease Day, NANBIOSIS reaffirms its commitment to advancing research and raising awareness of rare diseases such as Fabry disease. In this context, we are pleased to invite researchers, healthcare professionals, patient associations, and individuals affected by Fabry disease to the event “Fabry Connections: Science, Patients, and Future”, which will take place on Tuesday, April 29, 2025, at the ICMAB-CSIC. This event is organized by our Unit 6, Biomaterial Processing[...]

05 Feb

New Consequences in Familial Hypercholesterolemia due to Abnormal LDL

Misfolded ApoB100 in LDL promotes plaque buildup in familial hypercholesterolemia, raising cardiovascular risk. Structural preservation may aid prevention. Barcelona, febrero 2025. As recently published in the ICMAB webpage, a new study links ApoB100 protein structure (a key protein found in low-density lipoprotein, LDL, often called “bad cholesterol”) to increased cardiovascular risk in familial hypercholesterolemia. The study, led by IIBB-CSIC and CIBER, with the contribution of ICMAB’s SOFT Service (with NANBIOSIS Unit 6 at its core), shows that the protein structure directly contributes to an increased tendency to aggregate and form atherosclerotic plaques in patients with familial hypercholesterolemia. In these patients,[...]

29 Jan

A Breakthrough Therapy for Fabry Disease: nanoGLA Demonstrates Promising Results

Fabry disease therapy nanoGLA, developed by NANBIOSIS and our partners, shows superior efficacy in preclinical trials, targeting systemic and brain symptoms. Barcelona, january 2025. An international research team led by the Institute of Materials Science of Barcelona (ICMAB-CSIC) and CIBER-BBN, in collaboration with the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), has developed a groundbreaking nanotechnology-based therapy called nanoGLA for the treatment of Fabry disease. The innovative solution has shown remarkable efficacy in preclinical studies and has been published in the open-access journal Science Advances (see below for reference links). What is Fabry disease? Fabry disease is a rare genetic[...]

23 Oct

The Soft Lab held a new edition of the course on characterization and preparation of particulate materials

José Amable Bernabé, Technical Coordinator of Unit 6, hosted a course on “Characterization techniques for particulate materials”. Barcelona, october 2024. For yet another year, José Amable Bernabé, of the Soft Materials Service at ICMAB and Technical Coordinator of NANBIOSIS Unit 6, offered this course. The course was an explanation of different techniques to characterize nanoparticles and particulate matter, including the fundamentals of these techniques, sample preparation, practical examples and results interpretation. The course is offered every year through the CSIC training courses offered every year for all its staff, as reported in ICMAB webpage. Soft Materials Service The Soft Materials Service provides[...]

01 Mar

Reaching for the unreachable: New efforts to treat Lysosomal Storage Diseases

NANBIOSIS researchers pioneer novel treatments for Lysosomal Storage Diseases utilizing extracellular vesicles and liposomes, offering hope to patients. 1 March 2024, Vall d’Hebron Research Institute/ICMAB-CSIC (Barcelona) Lysosomal Storage Diseases (LSDs) encompass a group of rare disorders caused by mutations in lysosomal proteins. These mutations can lead to dysfunctional proteins responsible for breaking down cellular materials, resulting in the accumulation of deposits. Such accumulations can manifest in various neurological symptoms, ranging from progressive neurodegeneration to severe cognitive impairment. Often emerging in childhood, LSDs tragically culminate in premature death for many patients. Currently, up to 14 subtypes of LSDs can be treated[...]

21 Feb

The NABIHEAL Project Pioneers Wound Healing with New Biomimetic Matrices

Nearly 40 scientists across 7 countries are pioneering this breakthrough in wound healing using a nobel and affordable bio-inspired, anti-bacterial matrix. In addition to the vast consortium, the project also comprises 5 small and medium-sized enterprises (SMEs) and 9 academic institutions. These were convened last February at the University of Granada to share insights, progress, and strategies. According to an article published by UGR at the beginning of this month, about 40 researchers involved in the project have attended a meeting to share results and progress. The Horizon Europe project NABIHEAL, coordinated by the Biomedical Research Networking Center (CIBER) at[...]

U6-Biomaterial Processing and Nanostructuring Unit

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U9. Synthesis of Nanoparticles Unit

- Scientific Director: Prof. Jesús Santamaría jesus.santamaria@unizar.es

- Scientific Coordinator: Dr. José Luis Hueso jlhueso@unizar.es

- Entities: Instituto de Materiales y Nanociencia de Aragón (INMA)
- Address: R&D Building, Campus Río Ebro, Universidad de Zaragoza. C/Mariano Esquirl S/n, 50018, Zaragoza, Spain

- Phone: 34 976 761000 ext. 3496

- Web: https://nfp.unizar.es/

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Description

This unit, integrated in the Nanostructured Films and Particles Group at the Institute of Nanoscience and Materials of Aragón (INMA) coordinated by Dr. Jesús Santamaría, has as objective the synthesis of nanoparticles with applications in biomedicine. The unit provides an automated system for the synthesis of nanoparticles using laser-induced pyrolysis of chemical precursors in gas and/or aerosol phase, which enable either individual nanoparticles or biocompatible hybrid nanostructures to be produced in large quantities. In addition, this facility is able to draw on a wide range of nanoparticles fabrication technique, as well as having the necessary specialized personnel, to undertake exhaustive characterization of the microstructure, chemical composition, particles size and distribution of sizes, as well as magnetic, optical and colloidal properties and degree of biological functionality of the synthesized material.