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News U10

News U10

Three articles acknoledging NANBIOSIS contribution awarded at the Bioaraba Research and Innovation Conference

Researchers of NANBIOSIS U10 “Drug Formulation” – NanoBiocel research group from CIBER-BBN and UPV/EHU receives 3 awards in the category of Best International Articles at the annual Bioaraba Research and Innovation Conference.

On 4 November, the Bioaraba Health Research Institute held its XXIII Research and Innovation Conference in Vitoria. This important annual forum held in the city brings together professionals from the health system of Alava, the Rioja region of Alava, the Mental Health Network of Alava, the University of the Basque Country and also professionals from companies in R&D&I in health.

On this occasion, the NanoBioCel research group of the CIBER BBN and the ICTS Nanbiosis through the U10 Drug Formulation, won the 3 prizes in the category of Research and Innovation in the category of Best International Article. The first prize went to the article: Mesenchymal stromal cells encapsulated in licensing hydrogels exert delocalized systemic protection against ulcerative colitis via subcutaneous xenotransplantation. Written by Ainhoa Gonzalez-Pujana, Ana Beloqui, José Javier Aguirre, Manoli Igartua, Edorta Santos-Vizcaino, Rosa Maria Hernandez, published in the European Journal of Pharmaceutics and Biopharmaceutics in 2022. The second prize went to the article Nanodiamond Integration into Niosomes as an Emerging and Efficient Gene Therapy Nanoplatform for Central Nervous System Diseases whose authors are: Nuseibah AL Qtaish, Idoia Gallego, Alejandro J. Paredes,Ilia Villate, Cristina Soto-Sánchez, Gema Martínez, Myriam Sainz-Ramos, Tania B. López, Eduardo Fernández, Gustavo Puras, José Luis Pedraz. And the third prize went to the review: Cell microencapsulation technologies for sustained drug delivery: Latest advancesin efficacy and biosafety whose authors are: Tania B. López, Edorta Santos, José Luis Pedraz, Gorka Orive, Rosa María Hernández.

Articles of refernce:

Ainhoa Gonzalez-Pujana, Ana Beloqui, José Javier Aguirre, Manoli Igartua, Edorta Santos-Vizcaino, Rosa Maria Hernandez, “Mesenchymal stromal cells encapsulated in licensing hydrogels exert delocalized systemic protection against ulcerative colitis via subcutaneous xenotransplantation“, European Journal of Pharmaceutics and Biopharmaceutics, Volume 172,
2022, https://doi.org/10.1016/j.ejpb.2022.01.007

Nuseibah AL Qtaish, Idoia Gallego, Alejandro J. Paredes, Ilia Villate-Beitia, Cristina Soto-Sánchez, Gema Martínez-Navarrete, Myriam Sainz-Ramos, Tania B. Lopez-Mendez, Eduardo Fernández, Gustavo Puras, José Luis Pedraz. “Nanodiamond Integration into Niosomes as an Emerging and Efficient Gene Therapy Nanoplatform for Central Nervous System DiseasesACS Appl. Mater. Interfaces 2022, 14, 11, 13665–13677 https://doi.org/10.1021/acsami.2c02182

Tania B. Lopez-Mendez, Edorta Santos-Vizcaino, Jose Luis Pedraz, Gorka Orive, Rosa Maria Hernandez, “Cell microencapsulation technologies for sustained drug delivery: Latest advances in efficacy and biosafety,
Journal of Controlled Release”,
Journal of Controlled Release, Volume 335, 10 July 2021, Pages 619-636 https://doi.org/10.1016/j.jconrel.2021.06.006


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II Scientific Communication course

On October 18 and 19, was held the second course on Social Communication of Science, orgnized by NANBIOSIS U10 Drug Formulation Unit -(NanoBioCell Group of CIBER-BBN and UPV-EHU, this year entitled “Tools for the social communication of science“. The course aimed to provide doctoral students with communication with tools to be employed in their work as scientists when communicating their results or activity to the general public, patients, etc.

They first day was mainly dedicated to the use of metaphors in science communication, starting with an interesesting talk by Susana Martinez, director of the Incite Foundation; ateendees had the opportuniy to work case studies. On the second day, there were two different sessions: the first one about how to communicate science on the radio, led by the journalist Eva Caballero from the EiTB regional program “The mechanics of the snail”. and during the second session, a practical workshop was led by the group of theather “Porpol”, about on how to combat the stage fright.

This course was offered at the Doctoral School of the University of the Basque Country.

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The sprint of the European Project Moore4medical

The NanoBioCel group of the CIBER BBN, which also runs NANBIOSIS U10 Drug Formulation unit , organized the Workshop #6 of the Moore4medical European project at the Alava Technology Park on October 4, 5 and 6

The Central Building of the Álava Technology Park hosted the ‘Workshop #6’ of the European project which. 80 people belonging to 68 organizations, including private companies and research groups from universities and research centers from 13 countries of the European Union, participated in a meeting that has the leadership of the Dutch multinational Philips in its divisions of electronics and medical systems and service innovation

Moore4Medical Project
The three-year Moore4Medical project is funded by the public-private association ECSEL (Electronic Components and Systems for European Leadership), which manages a research and innovation program to strengthen the electronic components and systems sector in order to maintain the European Union at the forefront of technological development. The goal of the project is to accelerate innovation in electronic and microfabricated devices for various emerging medical specialties. The total financing of the project amounts to 68 million euros, of which more than half a million have been granted to the work of NanoBiocel.

NanoBiocel research group

The NanoBiocel research group from UPV/EHU, which is part of the CIBER BBN and the ICTS Nanbiosis through the U10 Drug Formulation, is led by Professor Jose Luis Pedraz, from the Faculty of Pharmacy of the Álava Campus. He participates in the European project Moore4medical on the optimization of the lyophilization process of biopharmaceutical products in microfluidic devices

Microfluidic Device
The University of the Basque Country is working, together with the Mondragón microLIQUID company, on the development of technology for the integration of lyophilized drugs and their rehydration in a microfluidic device for their correct administration. The lyophilized drug will be integrated into the microfluidic device using specific techniques to ensure good interaction between the fluid and the drug for delivery by the pump. The ultimate goal is to design a parenteral drug administration system that is much more comfortable for patients and improves therapeutic compliance with treatments.

The microLIQUID company is a benchmark biotechnological company in the microfluidic technology sector and is responsible for the design and development of microfluidic modules.

In this work called ‘Drug Adherence’, integrated within the total project, the NanoBioCel group has teamed up with the Irish national institute Tyndall, the pharmaceutical multinational AbbVie, the Fraunhofer Institute of Germany, the services innovation section of Philips, the German company Gaudlitz GmbH, specialist in polymers, the Technological Institute Karlsruhe in Germany and the company HI Iberia of Madrid.

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CRISPR technologies for Cystic Fibrosis treatment

Cystic fibrosis is an inherited genetic disease that mainly affects the lungs and the digestive system

On April 6, the first meeting was held, on the one hand, with people with Cystic Fibrosis and the Euskadi Cystic Fibrosis Association (Arnasa) and, on the other, with the NanoBioCel research group of the CIBER-BBN and the University of Basque Country, which is also part of the ICTS Nanbiosis through the Drug Formulation Unit U10.

The cooperative relationship between the NanoBioCel research group and Arnasa began approximately 5 years ago with the contributions made by the association to the NanBioCel group for research in cystic fibrosis.

The goup has focused on the development of non-viral vectors to address the treatment of cystic fibrosis through gene therapy. Progress is currently being made in the development of CRISPR technologies for its treatment.

This meeting was organized with the main objective of making those affected aware of the research carried out by NanoBioCel in cystic fibrosis and promoting associationism and collaboration between affected people and researchers to better understand the disease and find promising solutions.

The event was attended by almost 28 associates and many of the rest requested that the presentation of the researchers be recorded

Arnasa is the Cystic Fibrosis Association of the Basque Country and contributes with its work and activities to the promotion of general interest and the visibility of the disease, as well as to the improvement of the quality of life of people affected by the disease and their families.

In the picture: Increased activity of the chloride channel in CUFI cells transfected with non-viral vectors.

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1st Meeting with Cystic Fibrosis Patiens (NanoBioCel -ARNASA)

Cystic Fibrosis is a genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. It is a genetic, degenerative and chronic disease, with a population incidence is 1 in 5,000, so it is considered among the so called “Rare Diseases”

The most common symptoms are continuous colds, repeated infections, decreased lung capacity, impossibility of fat absorption and malnutrition

As there is no cure for the disease, daily treatment is the only option to have an acceptable quality of life

The NanoBioCell Research Group, which coordinates unit 10 of NANBIOSIS of the CIBER-BBN and the UPV/EHU, has a wide experience in comprehensive research into effective therapies for the treatment of cystic fibrosis and related diseases has organized the ‘First meeting with cystic fibrosis patients’ in the collaboration with ARNASA Bizkaia, (the Cystic Fibrosis Association of Bizkaia, made up of affected people, their families and volunteers who collaborate with the association)

Registration is free here. After registration you will receive a link to the online meeting

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The results of POSITION II highlighted by CORDIS: A pan-European alliance for the next generation of smart catheters

In the picture: microencapsulated cardiospheres 10X Captured Brightfield with DM_RGB_Brightfield with DM

The European project POSITION-II has been selected for publication in the ‘Results in Brief’ section of the Community Research and Development Information Service (CORDIS) website. CORDIS is the European Commission’s primary source of results from the projects funded by the EU’s framework programmes for research and innovation (FP1 to Horizon 2020).

The resulting short article has now been published on the CORDIS website in six languages.

The European project POSITION II “A pilot line for the next generation of smart catheters and implants” is an alliance of European leaders, united to improve technology and offer cheaper, easier to use, more efficient and technologically advanced catheters by incorporating sensors and real-time positioning and monitoring systems. This new generation of catheters will improve the treatment of multiple pathologies, through new therapeutic tools such as cell therapy and tissue engineering implemented in the project by the U10 Drug Formulation of the ICTS Nanbiosis, which is integrated in the NanoBioCel group of CIBER-BBN and UPV/EHU.

The following actions have been carried out in NANBIOSIS U10 Drug Formulation during the execution of the project:

– Isolate, expand and characterize cardiosphere-derived cells (CDCs). CDCs were  isolated from porcine cardiac tissue, and their  release profile of immunomodulatory factors was determined.

– To optimize the encapsulation conditions of CDCs in alginate microcapsules.

– Evaluate whether the physical and chemical properties of the encapsulated CDCs were suitable for the catheter developed in the project.

– Determine that the secretion profile of trophic factors did not change in CDCs after encapsulation.

– Provide the TME Lab group and NANBIOSIS U13 of CIBER-BBN and the University of Zaragoza with the microcapsules and encapsulated CDCs required for their mechanical characterization and to evaluate the behavior of the capsules in the catheter and in the animals at the NANBIOSIS units of Center for Minimally Invasive Surgery in Extremadura (CCMIJU). Other collaborations during the execution of the project were established with the Fraunhofer EMFT group in Germany and with the Spanish company IberHospitex, manufacturer of the catheters.

Other related news:

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AWARDS of the Academy of Pharmacy of Castilla y León 2021 to researchers from NANBIOSIS U10

The leader of the NanoBioCell Group form CIBER-BBN and UPV/EHU, Jose Luis Pedraz, and the reaearches Laura Saenz del Burgo and Markel Lafuente have received the 2021 Award from the Academy of Pharmacy of Castilla y León, on February 4, at the city ​​of Salamanca, for the work entitled: “Design and Characterization of a biotin formulated with nanocellulose, alginate and Gags for use in 3D bioprinting and application in cartilage regeneration“, the content of this research work has been published in the Journal Macromolecular Science under the title: “Chondroitin and Dermatan Sulfate Bioinks for 3D Bioprinting and Cartilage RegenerationThe pharmacotechnical and rheological characterization work of the designed bioinks has been carried out in the U10 Drug Formulation of the Nanbiosis ICTS of the Faculty of Pharmacy of the University of the Basque Country and CIBER-BBN.


In addition, Prof. Jose Luis Pedraz has been appointed Corresponding Academician at the Academy of Pharmacy of Castilla y León.


Also the researcher of the NanoBiocel group, Professor Edorta Santos Vizcaíno, belonging to the CIBER BBN and the U10 Drug Formulation of the Nanbiosis ICTS, and María Gil Atienza, have been recognized that same day, with a second prize by the Academy of Pharmacy of Castilla y León for the research work: “Use of extracellular vesicles to transport antitumor agents in the treatment of cancer”. This work was carried out in the Laboratory of Pharmacy and Pharmaceutical Technology of the University of the Basque Country.

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Best Emergeging Researcher Award in the Biomedical Area to Edorta Santos

Edorta Santos Vizcaíno has been awarded as Best Emerging Researcher in the biomedical area by the Bioaraba Health Research Institute in the XXII edition of the Research and Innovation Conference.

This award aims to recognize the work of researchers under the age of 40 who carry out their research activity in any public center of the Araba Health Network (OSI ARABA UNIVERSITY HOSPITAL / BIOARABA). The main award´’s criteria are the quality of the research carried out, active participation in public and private research projects, fidelity to the line of biomedical research and the usefulness and interest of the research developed for the environment are valued. The award also carries a financial endowment destined to continue promoting the research career of the awarded person.

Edorta Santos Vizcaíno (NANBIOSIS Unit 10 “Drug Formulation”) has a degree in Biochemistry and a doctorate in Pharmacy, with an international mention and an extraordinary award, from the UPV / EHU. He has been part of the research group NanoBioCel of the UPV / EHU, Consolidated Group of Excellence of the Basque university system, since 2006. In the same way, he is a member of the Center for Biomedical Research in Network for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), a consortium dependent on the Carlos III Health Institute through the Ministry of Science and Innovation, and the Bioaraba Health Research Institute. Edorta has extensive experience in cell therapy and drug delivery systems. During the last years, his research has focused on the biomedical application of different biomaterials (for example, alginate, gelatin, collagen), mesenchymal stem cells (MSC) and their secretome (extracellular vesicles and soluble factors), in order to exert a immunomodulatory and regenerative effect in the treatment of immune-mediated inflammatory diseases (for example, inflammatory bowel disease, IBD) and the regeneration of chronic wounds, among other applications.

Bioaraba‘s mission is to develop research and innovation of excellence and quality that allows the translation of its results aimed at solving the health problems of the population, also promoting scientific research and for this, it annually carries out the Research and Innovation Conference.

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New Equipment available for the Regenerative Medicine Research Line of the U10 of NANBIOSIS

The Unit 10 of Drug Formulation of the ICTS NANBIOSIS coordinated by the CIBER-BBN NanoBioCel group directed by Jose Luis Pedraz, which belongs to the University of the Basque Country, has been present at the signing of the agreement that gives support by the Provincial Council of Alava within the framework of the Advance Pharma Development project, together with the research and technological development center TECNALIA. 

With this agreement, the NanoBioCel research group will receive in the next two years (2021-2023) a contribution of 650,000 €, which will allow the hiring of research personnel and the purchase of specific equipment for the regenerative medicine research line. The first equipment purchased to strengthen U10 in Bio-printing is the RegenHU Bioprinter: R-GEN 100, which will be located in the P3 Laboratory of the Lascaray Research Building. This bioprinter will bring two new technologies to the bioprinting techniques currently being used at U10: extrusion and droplet techniques. With RegenHU it will be possible to work with two new bioprinting processes: electrospinning and electrowriting. Electrospinning is a promising technique for the controlled release of drugs and electrowriting (electrostatic writing) will allow the construction of scaffolds with variable diameters in their design and elaboration.

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Results of the POSITION-II Project “A pilot line for the next generation of smart catheters and implants”

Cáceres, October 14th, 2021

POSITION II has received funding within the Electronic Components and Systems for European Leadership Joint Undertaking (ECSEL JU) in collaboration with the European Union’s H2020 Framework Programme (H2020/2014-2020) and National Authorities, under grant agreement Ecsel-783132-Position-II-2017-IA.

It promotes innovation in smart medical instruments and focuses in the next generation of smart catheters and implants by the introduction of open technology platforms for: miniaturization, in-tip AD conversion, wireless communication, MEMS transducer technology and encapsulation. These platforms are open to multiple users and for multiple applications.

POSITION II will enable the further development of the European R&D and manufacturing capability, not only encompassing the micro-fabricated device itself, but also the various value chains that they enable. Finally, by bringing smart catheters into the domain of high volume manufacturing, POSITION II will improve the quality of health-care at manageable cost.

The project, led by Philips Electronics Netherlands B.V, has been developed by 45 partners located in 12 different countries and has finished in September 2021. Within this large collaborative project, the NANBIOSIS units at CCMIJU have been involved in the validation of a novel catheter to administer encapsulated cell therapy to the heart. Also NANBIOSIS U10 Drug Formulation unit of CIBER-BBN and UPV/EHU , has participated being responsible for carrying out the formulation of the cells in hydrogels, for administration through the catheter at the cardiac level, for the regeneration of heart tissue.

The results of the project are available on a video-format documentary that contains short interviews to the consortium partners on their participation. Specifically, CCMIJU has presented its work and results through a short interview to Dr. Verónica Crisóstomo, Coordinator of Cardiovascular Unit. The documentary can be found at https://vimeo.com/604674309/bd8b94050c

Further info about the project here: http://position-2.eu/

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