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Preclinical validation tissue, biomaterialls and surfaces characterization -Services

Preclinical validation tissue, biomaterialls and surfaces characterization -Services

U19-S03. Clinical Analysis Laboratory (On-site&Remote) OUTSTANDING

Clinical Analysis Laboratory

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U14-S06. Lymphocyte proliferation assay (On-site&Remote) OUTSTANDING

Lymphocyte proliferation assay

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U14-S05. Determination of cytokine concentration by flow cytometry (On-site&Remote) OUTSTANDING

Determination of cytokine concentration by flow cytometry

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U14-S04. Cytokine quantification assays (On-site&Remote) OUTSTANDING

Cytokine quantification assays

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U14-S03. Biomecanic evaluation of plantar pressure in large animal models (On-site) OUTSTANDING

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U13-S08. ATOMIC FORCE MICROSCOPY IDENTATION TEST (On-site) OUTSTANDING

ATOMIC FORCE MICROSCOPY IDENTATION TEST

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U19-S01. Preclinical Studies (Onsite&Remote) OUTSTANDING

Preclinical regulatory in vivo toxicity, local and systemic tolerance and PK/PD studies; dosing of test and specimen drawing, biocompatibility studies of medical devices; Safety studies: Nervous, cardiovascular and respiratory systems.

Security testing of advanced therapies using small and large animals models.

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U18-S01. In vitro Nanotoxicology (Remote) OUTSTANDING

Assays of cell viability/toxicity by XTT, release of LDH and similar indicators.

  • Study of toxicity in normal human cells immortalized by viral infection or tTERT, by means of metabolic XTT test,
  • Production of reactive oxygen species (ROS ) by fluorimetry.

Internalization assays

  • Study of the mechanism of toxic action
  • Analysis of hemocompatibility in blood
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U18-S02. In vivo Nanotoxicology, preclinical histopathology in animal models (Remote) OUTSTANDING

Sample preparation, inclusion, section and staining for preclinical histology (paraffin and frozen samples) as well as anatomopathological evaluation.

Complete necropsy:

  • Hematology
  • ADME/Tox of nanoparticles
  • Study of distribution of markers of interest by immunohistochemistry.
  • Study of the mechanism of toxic action (apoptosis, caspase-independent death, autophagia, necrosis).
  • Preclinical toxicity assays in animal models.

Product characterization studies, solubility and other properties studies; Inmunoassay techniques; Molecular biology techniques; Cell culture techniques; Flow cytometry; Safety studies: Nervous, cardiovascular and respiratory systems; Toxicology studies; PK/PD studies, Security testing of advanced therapies using small and large animals models.

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U18-S03.  In vivo TOXICOLOGY (Onsite&Remote) OUTSTANDING

Complete necropsy:

  • Hematology
  • ADME/Tox of nanoparticles
  • Study of distribution of markers of interest by immunohistochemistry.
  • Study of the mechanism of toxic action (apoptosis, caspase-independent death, autophagia, necrosis).
  • Preclinical toxicity assays in animal models
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