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Preclinical validation tissue, biomaterialls and surfaces characterization -Services

Preclinical validation tissue, biomaterialls and surfaces characterization -Services

U30-S02. Determination of molecular mass of peptides, proteins and other biomolecules

Determination of molecular mass of peptides, proteins and other biomolecules.

Description: Analysis of intact proteins, peptides and other biomolecules such as oligonucleotides using mass spectrometry (MALDI-TOF or ESI-Q-TOF) for the determination of their exact molecular mass.

Applications: Characterization of biomolecules.

U30 S02 Determination of molecular mass of peptides, proteins and other biomolecules
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U30-S01. Sample preparation for proteomic analysis

Sample preparation for proteomic analysis

Description: This service includes all necessary steps to prepare samples for different proteomic analyses: protein extraction from tissues, cells or fluids, precipitation, cleaning, desalting, quantification and digestion (in gel or in solution) with proteolytic enzimes (trypsin, chymotrypsin, lys-C…), to obtain the correspondent peptides.

Applications: All experiments involving proteins.

U30 S01 Sample preparation for proteomic analysis
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U19-S03. Clinical Analysis Laboratory (On-site&Remote) OUTSTANDING

Clinical Analysis Laboratory

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U14-S06. Lymphocyte proliferation assay (On-site&Remote) OUTSTANDING

Lymphocyte proliferation assay

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U14-S05. Determination of cytokine concentration by flow cytometry (On-site&Remote) OUTSTANDING

Determination of cytokine concentration by flow cytometry

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U14-S04. Cytokine quantification assays (On-site&Remote) OUTSTANDING

Cytokine quantification assays

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U14-S03. Biomecanic evaluation of plantar pressure in large animal models (On-site) OUTSTANDING

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U13-S08. ATOMIC FORCE MICROSCOPY IDENTATION TEST (On-site) OUTSTANDING

ATOMIC FORCE MICROSCOPY IDENTATION TEST

Software AFM
Curva Fuerza
Cápsulas
Cantilever + célula

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U19-S01. Preclinical Studies (Onsite&Remote) OUTSTANDING

Preclinical regulatory in vivo toxicity, local and systemic tolerance and PK/PD studies; dosing of test and specimen drawing, biocompatibility studies of medical devices; Safety studies: Nervous, cardiovascular and respiratory systems.

Security testing of advanced therapies using small and large animals models.

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U18-S01. In vitro Nanotoxicology (Remote) OUTSTANDING

Assays of cell viability/toxicity by XTT, release of LDH and similar indicators.

  • Study of toxicity in normal human cells immortalized by viral infection or tTERT, by means of metabolic XTT test,
  • Production of reactive oxygen species (ROS ) by fluorimetry.

Internalization assays

  • Study of the mechanism of toxic action
  • Analysis of hemocompatibility in blood
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