Singular

U24-S02. Medical Imaging for Minimally Invasive Surgery (Onsite&Remote) OUTSTANDING

Medical Imaging for Minimally Invasive Surgery

Advancements in medical technologies have enabled the development and regular use of minimally invasive procedures, which could also be termed image-guided surgery. A platform that can integrate the different imaging techniques is pivotal to aid their development.
NANBIOSIS Unit 24 has medical grade imaging (i.e. Cardiac Magnetic Resonance including delayed enhancement, high performance ultrasound systems, flat panel fluoroscopes, intravascular optical coherence tomography) integrated in a surgical environment, so that these technologies are available for comprehensive follow up of interventions or new surgical approaches. Generally, image acquisition is performed at baseline and serially during the predetermined duration of the study in order to assess the effectiveness of these surgeries on measurable endpoints to document improvement.

Customer benefits

The studies are tailored to the needs of each specific candidate intervention, can be implemented with different follow-up times and can be performed under regulatory requirements, since the performing institution is Certified for Good Laboratory Practices.
Thus the Service can be provided as proof-of-concept studies, full safety and efficacy or under GLPs to meet regulatory agencies’ guidelines and assure clinical translation, so that the customers can take their therapy to a clinical trial faster and more efficiently, thanks to the full range of capabilities offered in this service.

Target customer

The offered service can be of interest to scientists from academia willing to test a possible surgery and perform serial follow up of its outcomes, early-stage medical professionals requiring training in minimally invasive surgery, late-stage surgeons that need to test an idea for an improved surgical approach, commercial companies that need to test the implantation of a device and its effect under GLP studies to commercialize their product.

References

• Lucas-Cava V, Sánchez-Margallo FM, Dávila-Gómez L, Lima-Rodríguez JR, Sun F. Prostatic artery occlusion versus prostatic artery embolisation for the management of benign prostatic hyperplasia: early results in a canine model. Br J Radiol. 2022 Aug 1;95(1136):20220243. doi: 10.1259/bjr.20220243. Epub 2022 Jul 7. PMID: 35762334; PMCID: PMC10162044.
• Sánchez-Margallo JA, Tas L, Moelker A, van den Dobbelsteen JJ, Sánchez-Margallo FM, Langø T, van Walsum T, van de Berg NJ. Block-matching-based registration to evaluate ultrasound visibility of percutaneous needles in liver-mimicking phantoms. Med Phys. 2021 Dec;48(12):7602-7612. doi: 10.1002/mp.15305. Epub 2021 Oct 31. PMID: 34665885; PMCID: PMC9298012.
• Sánchez-Margallo FM, Veloso Brun M, Sánchez-Margallo JA. Identification of intra-abdominal lymphatics in canine carcasses by laparoscopic fluorescence lymphography with intradermal and intrapopliteal ICG administration. PLoS One. 2020 Nov 12;15(11):e0241992. doi: 10.1371/journal.pone.0241992. PMID: 33180854; PMCID: PMC7660503.
• Sánchez-Peralta LF, Picón A, Sánchez-Margallo FM, Pagador JB. Unravelling the effect of data augmentation transformations in polyp segmentation. Int J Comput Assist Radiol Surg. 2020 Dec;15(12):1975-1988. doi: 10.1007/s11548-020-02262-4. Epub 2020 Sep 28. PMID: 32989680; PMCID: PMC7671995.
• Crisostomo V et al. Dose-dependent improvement of cardiac function in a swine model of acute myocardial infarction after intracoronary administration of allogeneic heart-derived cells. Stem Cell Res Ther. 2019 May 31;10(1):152. doi: 10.1186/s13287-019-1237-6. PMID: 31151405; PMCID: PMC6544975.