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JUMISC

Filtered Air Shower for Animal Housing

Cáceres, September 10th, 2021

In the framework of the project “Updating the Infrastructures and implementation of a LIMS document control and management system to enhance the capacities of the Distributed ICTS NANBIOSIS Units managed by the CCMIJU (AILIMS-NANBIOSIS)  a filtered air shower for Animal Housing has been bought with strictly controlled environmental parameters, to prevent possible cross-contamination and the entry of pathogens and viral particles, since during  entry and exit of personnel to this area, contamination by the mentioned particles has been detected, so the air shower is an effective solution to eliminate them and protect the controlled environment.

AILIMS has been co-funded by the European Regional Development Fund (FEDER) within the framework of the Pluriregional Operational Program of Spain (POPE) of Singular Scientific and Technical Infrastructures (ICTS) 2014-2020 and the acquisition of the shower is part of the first action of the following two, financed with FEDER Funds:

-Within Unit 22 or Animal Facility, the Installation and development of an environmental treatment-control system of the housing rooms, an Improvement and adaptation of the spaces for experimental models, the Acquisition, installation and development of a two-door ultra- filtered air shower and the Acquisition, installation and development of a post-procedural recovery chamber.

– For the rest of the NANBIOSIS Units managed by the CCMIJU, Acquisition, installation and development of a LIMS Software.

The actions and their budget are here detailed: (VI) PROJECT REFERENCE: ICTS-2019-14-46), together with the FEDER co-funded rate.

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Characterization of encapsulated porcine cardiosphere-derived cells for cardiac regeneration.

Researchers of NANBIOSIS U10 Drug Formulation unit of CIBER-BBN and UPV/EHU and NANBIOSIS U14 Cell Therapy unit and U24 Medical imaging unit at CCMIJU have participated in a research that proposes the use of encapsulated cardiosphere-derived cells (CDC), obtained from heart tissue, as regenerative cell therapy.

The encapsulation of the cells has been carried out in NANBIOSIS Unit 10, as well as the characterization of the cells (both encapsulated and unencapsulated) for their application in regenerative medicine (cardiac regeneration); and unit 14 of NANBIOSIS has obtained the cell model used for the study “ – Explains Kaoutar Ziani Akrirout, research scientists of CIBER-BBN and NANBIOSIS Unit 10.

These cells are multipotent stem cells, which secrete growth factors capable of promoting revascularization and healing of infarcted tissue. However, the use of this therapy faces a great challenge, which is the survival and retention of these cells after their implantation in the infarcted area, since the heart is a tissue that is constantly contracting and expanding, which leads to the loss of these cells, as they are carried along by the bloodstream.

To solve the low retention of cells, members of the NanoBioCel research team, from the CIBER-BBN and attached to the Bioaraba Health Research Institute (IIS Bioaraba), in collaboration with researchers from the IIS Aragón and the CIBERCV, propose the encapsulation of the CDC of porcine origin within a three-dimensional alginate-poly-L-lysine-alginate matrix as a therapy for cardiac regeneration, since, thanks to this, the encapsulated cells will be able to remain adhered to the tissue for longer, giving them time to exercise their function. The final objective will be to verify its efficacy in swine infarction models.

The team has verified that the phenotypic characteristics, the gene expression profile, the ability to differentiate to other cell lines and the release of growth factors from these cells are not altered by the encapsulation process, essential aspects given that their preservation it is essential for cardiac regeneration. In addition, this procedure keeps them viable for a month, which would favor the possible regeneration of the tissue.

On the other hand, that a sustained release of growth factors is maintained in these cells suggests that the implantation of encapsulated CDCs will promote the formation of new blood vessels and, consequently, the regeneration of infarcted cardiac tissue.

The researchers suggest that encapsulated CDCs could be a highly interesting therapeutic alternative in the field of cardiac regenerative medicine.

Article of reference

Ziani K, Espona-Noguera A, Crisóstomo V, Casado JG, Sanchez-Margallo FM, Saenz-Del-Burgo L, Ciriza J, Pedraz JL. Characterization of encapsulated porcine cardiosphere-derived cells embedded in 3D alginate matrices. Int J Pharm. 2021 Apr 15;599:120454.[DOI

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Online Course in Basic Procedures and Introduction to Mesenchymal Stem Cell Culture

From 30 August 2021 to 29 September 2021 Jesus Usón Minimally Invasive Surgery Centre (JUMISC) has organized an on line course on Procedures and Introduction to Mesenchymal Stem Cell Culture. The course is directected by Francisco Miguel Sánchez Margallo and run by researchers of NANBIOSIS U14 Cell Therapy Unit at JUMISC

Stem cells are cells capable of differentiating into a wide variety of cell types and can be isolated from different tissues. They have regenerative and anti-inflammatory properties thanks to the secretion of paracrine factors. Currently, these cells are being widely used in clinical trials for the treatment of different diseases such as Crohn’s disease, multiple sclerosis, diabetes, rheumatoid arthritis or myocardial infarction.

The objectives of this course is to teach the student to work in cell culture rooms, perform stem cell isolations, as well as the maintenance, expansion and conservation of these cell lines. You will also learn to characterize and differentiate these cell lines.

Once the course is finished, the student will be able to know the necessary equipment in a cell culture laboratory, the risks derived from working in these laboratories and the basic rules that must be taken into account to work in cell culture rooms. The student will also learn to prepare culture media, isolate stem cells from different tissues and everything necessary for the maintenance, expansion and conservation of cell lines. In addition, she will be able to acquire knowledge related to the differentiation protocols to different lineages: adipogenic, osteogenic and chondrogenic differentiation.

▶ DIRECTORS

Francisco Miguel Sánchez Margallo
Scientific Director of CCMIJU / Deputy Scientific Director of NANBIOSIS

Esther Lopez Nieto
Researcher at the Cell Therapy Unit of NANBIOSIS
of the JUMISC

▶ TEACHERS

Dr Javier García Casado.
Scientific Director of NANBIOSIS U14 Cell Therapy Unit
Postdoctoral researcher at the Cell Therapy Unit of the JUMISC

Dr Esher López.
Researcher at the Cell Therapy Unit of the JUMISC / NANBIOSIS

Federica Marinaro.
Researcher at the Cell Therapy Unit of the JUMISC / NANBIOSIS

Mª de los Angeles de Pedro
Researcher at the Cell Therapy Unit of the JUMISC / NANBIOSIS

Maria Pulido
Researcher at the Cell Therapy Unit of the JUMISC / NANBIOSIS

Veronica Alvarez.
JUMISC Superior Laboratory Technician

Information and enrollment here

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Purchase, installation and implementation of a treatment, distribution and management system for the environmental control and registration of animal housing rooms

There is a growing demand, coming from the scientific community, to carry out studies with animal models in the best conditions for them. For this reason, the need of implementing a new control and recording system of environmental conditions within the stabling rooms of the CCMIJU Animal Housing arises.

The whole process and the awarded company, General de Instalaciones y Conservación S.L., have been published in the following link of the Public Sector Contracting Platform, within the framework of the project “Updating of the Infrastructures and implementation of a document control and LIMS management system to enhance the capacities of the NANBIOSIS Distributed ICTS Units managed by the CCMIJU (AILIMS-NANBIOSIS)”

Link

AILIMS has been co-funded by the European Regional Development Fund (FEDER) within the framework of the Pluriregional Operational Program of Spain (POPE) of Singular Scientific and Technical Infrastructures (ICTS) 2014-2020.

The following actions are considered in the framework of the project:

-Within Unit 22 or Animal Facility, the Installation and development of an environmental treatment-control system of the housing rooms, an Improvement and adaptation of the spaces for experimental models, the Acquisition, installation and development of a two-door ultra- filtered air shower and the Acquisition, installation and development of a post-procedural recovery chamber.

– For the rest of the NANBIOSIS Units managed by the CCMIJU: Acquisition, installation and development of a LIMS Software.

The actions and their budget are detailed below, together with the FEDER co-funded rate and the national contribution.

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Awarded works for improvement and adaptation of the spaces for the maintenance of the experimental models in the CCMIJU’s Animal Housing

The Public Sector Contracting Platform has published the awarding to the company “Depur GM Deseño e Obra S.L” to carry out the improvement works in the CCMIJU’s Animal Housing within the framework of the project “Updating the Infrastructures and implementation of a LIMS document control and management system to enhance the capacities of the Distributed ICTS NANBIOSIS Units managed by the CCMIJU (AILIMS-NANBIOSIS).

For further details, please click here

The mentioned project has been co-funded by the European Regional Development Fund (FEDER) through the Ministry of Science and Innovation within the framework of the Programa Operativo Plurirregional de España (POPE) for Singular Scientific and Technical Infrastructures (ICTS) 2014-2020 and by the Consejería de Economía, Ciencia y Agenda Digital of Junta de Extremadura.

The following actions are considered in the framework of the project:

-Within Unit 22 or Animal Facility, the Installation and development of an environmental treatment-control system of the housing rooms, an Improvement and adaptation of the spaces for experimental models, the Acquisition, installation and development of a two-door ultra- filtered air shower and the Acquisition, installation and development of a post-procedural recovery chamber.

– For the rest of the NANBIOSIS Units managed by the CCMIJU: Acquisition, installation and development of a LIMS Software.

The actions and their budget are detailed below, together with the FEDER co-funded rate and the national contribution.

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Researchers of NANBIOSIS at CCMIJU units invited to co-edit a collection of video articles by the Journal of Visualized Experiments (JOVE)

Verónica Crisóstomo, Scientific Director of NANBIOSIS unit 24 Medical imaging and Coordinator of the Cardiovascular area at CCMIJU afiliated to the Centro de Investigación Biomédica en Red Cardiovascular (CIBER-CV), along with Claudia Báez, researcher of that area, have been invited to co-edit the collection of video articles for JOVE.

Have you ever tried to reproduce a methodology you have only read about on a paper? When we try it, we normally end up wishing we could see how the authors actually do it” – explain the researchers. 

To date, very few Journals are available to accept video articles for submission/publication in our field, despite this type of articles being of paramount importance in translational cardiovascular research in order to share new techniques and approaches.

For this reason, reeaearchers decided to start a Collection entitled Large Animal Models of Cardiovascular Diseasefrom Training to Translation on JoVE, whose purpose is to offer a comprehensive overview and a visual guide to how successfully reproduce cardiovascular disease models in large animals with the ultimate aim of bridging the gap from bench to bedside.

The Journal is currently indexed in the major databases, including PubMed, EMBASE, Scopus and Web of Science. The most recent Impact Factor for JoVE (ISSN 1940-087X) is 1.163 in JCR. 

JoVE’s team takes care of the entire process of filming and producing the video: after submission, each manuscript will be editorially and peer reviewed, which is typically a 1-2 month process. Once a text article passes review, a script will be generated. Generally, a filming date will be scheduled within 4-8 weeks after acceptance. A videographer will be sent to the authors’ site to film the procedure.

If interested, please contact by email crisosto@ccmijesususon.com or  cbaez@ccmijesususon.com   or submit the  abstract here:  https://www.jove.com/methods-collections/1004

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Course on Introduction to Research and Laboratory Techniques in Biosciences

CCMIJU has organised the IV Course on Introduction to research and laboratory techniques in Biosciences, which wil take place at JUMISC from May, 3th to June 6th 2020 under the Direction of Javier García CasadoScientific Director of NANBIOSIS U14 Cell Therapy and Francisco Miguel Sanchez Margallo Deputy Scientific Director of NANBIOSIS. Other researchers of NANBIOSIS Units offer their expertise as Beatriz Moreno Lobato, Scientific Diector NANBIOSIS U19 and Luis Dávila Gómez, Scientific Director of NANBIOSIS U22.

The course include:

KNOWLEDGE PILLS FOR RESEARCH
EXERCISES AND CASE STUDIES I
RNA and DNA: GENE EXPRESSION AND GENETIC STUDIES IN REPRODUCTION.
EXERCISES / CASE STUDIES II
PROTEINS AND PROTEOMA: PROTEIN EXPRESSION STUDIES AND PROTEOMIC MASS IDENTIFICATION / IDENTIFICATION.
CELL CULTURES: STEM CELL CULTURES, PRODUCTION FOR CLINICAL USES.
MISCELLANEOUS: HISTOLOGY, CLINICAL ANALYSIS, 3D BIOPRINTING AND ANIMAL EXPERIMENTATION.
FINAL EXAMINATION

Further information and registration at Campus CCMIJU

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Supply, installation and implementation of a document control system, LIMS management and equipment, to enhance the capacities of the distributed ICTS Units (NANBIOSIS -AILIMS).

The project “Updating the Infrastructures and implementation of a LIMS document control and management system to enhance the capacities of the Distributed ICTS NANBIOSIS Units managed by the CCMIJU (AILIMS-NANBIOSIS) ‘has been co-funded by the European Regional Development Fund (FEDER) within the framework of the Pluriregional Operational Program of Spain (POPE) of Singular Scientific and Technical Infrastructures (ICTS) 2014-2020.

The following actions are considered in the framework of the project:

-Within Unit 22 or Animal Facility, the Installation and development of an environmental treatment-control system of the housing rooms, an Improvement and adaptation of the spaces for experimental models, the Acquisition, installation and development of a two-door ultra- filtered air shower and the Acquisition, installation and development of a post-procedural recovery chamber.

– For the rest of the NANBIOSIS Units managed by the CCMIJU: Acquisition, installation and development of a LIMS Software.

Within this last action, tender with reference number 02S/2021 on Supply, installation and implementation of a LIMS document control and management system, as well as the necessary equipment for its correct operation, has been published and has already been awarded.

The actions and their budget are here detailed: (VI) PROJECT REFERENCE: ICTS-2019-14-50), together with the FEDER co-funded rate.

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Launching the Preliminary Market Consultation Webinar of the TREMIRS Project: Minimally Invasive Robotic Surgical Systems

Cáceres, April 15th, 2021

The CCMIJU, as a beneficiary of the Innovative Public Procurement Program of the Ministerio de Ciencia e Innovación, through the project “Minimally Invasive Robotic Surgery Systems” (TREMIRS), will invest € 7,345,300 in the development of innovative solutions in surgical robotics to improve services provided to the patient, the surgeon’s ergonomics and offer greater benefits to the surgical team, thus achieving an increase in the quality of healthcare.

This ambitious challenge, 80% co-funded by the European Regional Development Fund under the Programa Operativo Plurirregional de España (POPE) 2014-2020 and by the Consejería de Economía, Ciencia y Agenda Digital de la Junta de Extremadura, will last three years and will develop two innovative solutions in the field of surgical robotics, one focused on laparoscopic robotic surgery and the other on microsurgical robotics.

The first solution will facilitate new surgical approaches, provide improvements in surgeon ergonomics, advances in surgical assistance systems, and new portable training tools. The second will implement robotic micro-instruments for soft tissue manipulation and for performing microsurgical techniques such as anastomosis, suturing and ligation on small anatomical structures such as blood vessels, nerves and lymphatic ducts.

The development of both platforms will provide the National Health System and the Extremadura Health Service new equipment that is not currently available on the market and that will improve the quality of patient services and surgical results.

The project is currently in the preliminary market consultation phase as a prior action to the Innovative Public Procurement procedure for the aforementioned solutions. The purpose of this consultation is to obtain information about innovative solutions that respond to the challenges of the project through technologies that exceed the benefits of the existing ones. The results of this consultation will allow us to define the technical and functional specifications of the solutions to be achieved with a subsequent public procurement process.

You can find more information about the project and the preliminary market consultation at the free webinar on April 21, 2021 at 10:00 am.

Registration: https://www.ayming.es/insights-y-noticias/eventos/jornada-presentacion-consulta-preliminar-mercado-proyecto-tremirs-sistemas-cirugia-robotica-minima-invasion/

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CAMPUS JUMISC online training

The Jesús Usón Minimally Invasive Surgery Center, CCMIJU, partner of NANBIOSIS, offer high quality training based on itslearning philosophy perfectly adapted to new teaching methodologies and to a more dynamic and interconnected world.

The CCMIJU Campus responds to the new modalities of online training and education. Based on their interests and objectives, students choose the course to suit their level and learning pace, being able to interact with expert tutors through social networks. Emerging as a complement to face-to-face activity, the CCMIJU Campus offers high quality training adapted to new methodologies, and to a more dynamic and intercommunicated world.

The only training modality provides a self-paced learning for those who need to start completing the targets at any time and can arrange their schedule to satisfy individual needs. All lectures, videos and needed materials are provided via this online platform.

The face-to-face courses offer a pyramid training system with two training modalities: Set courses (Scheduled activities monitored by trainers of different specialties) and Under-request courses (Training courses on minimally invasive surgery techniques, addressed to medicine professionals to improve their skills in the use of new techniques, devices and equipment)

Further information: https://www.campusccmiju.com/

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