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News U2

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High quality antibodies for very challenging projects

Researchers of Nb4D group – Unit 2 of the ICTS NANBIOSIS (led by Pilar Marco, from CIBER-BBN and the IQAC-CSIC) have participated in Expoquimia 2021, the International Chemistry Meeting, which took place from 14 to September 17 at the Fira de Barcelona.

The researchers presented their work in several projects: the FoodSmartPhone project (MSCA-ITN-720325 action), the QS4CF (RTI2018-096278-B-C21), the QS-Motion (TV32018-201825-30-31) and on the PoC4CoV project (PIE-202050E090; PTI Salud Global, CSIC).

Research at the FoodSmartPhone(MSCA-ITN-720325 action) is focus on developing devices for the monitoring of contaminants of interest in food safety through the use of mobile phones. The production of the necessary antibodies for the detection of antibiotics and pesticides has been carried out by NANBIOSIS U2 Custom Antibody Service (CAbS). These are very specific monoclonal antibodies against pesticides, used by researchers Klaudia Kopper and Julian Guercetti to bind them to the functionalized surface and implemented in plasmonic detection sensors for antibiotics in milk and electrochemical biosensors for the detection of pesticides in cereals.

The scientific activity within the QS4CF (RTI2018-096278-B-C21) and QS-Motion (TV32018-201825-30-31) is focused on the Quorum Sensing communication system as an strategy to develop more efficient and specific diagnostic tools and therapeutic approaches to diagnose and treat P. aeruginosa and S. aureus infections.

The PoC4CoV project (PTI Salud Global, CSIC) seeks a comprehensive approach to diagnose COVID-19 developing devices to detect genetic material and proteins of the SARS-CoV2 virus, but also the response of the host against the infection. High quality antibodies against SARS-CoV-2 structural proteins (spike and nucleocapsid) have been produced by CAbS at NANBIOSIS

The camera flash is able to excite the functionalized surface of the chip and generate the specific response to the contaminant. This signal is picked up by the mobile through a Bluetooth connection and quantified.

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The European Researcher’s Night with NANBIOSIS’ scientists.

The European Researchers’s Nigth is a public event dedicated to the dissemination of science that is held every year in more than 300 cities in 30 countries of Europe at the same time, organized on the last Friday and Saturday of September.

This year face-to-face activities are progrmmed in different locations of Catalonian cities and also the “Nit de la Recerca” YouTube channel offers more than 20 noves microxerrades led by researchers from Catalonia.

Two NANBIOSIS’ researchers have joined this event to explain their research:

Julian Guercetti – Nb4D Group – NANBIOSIS U2 CAbS, from IQAC-CSIC and CIBER-BBN, will give two Face-to-face micro-talks entitled “Tell me who you hang out with and I’ll tell you … what antibodies you have!” and “Small solutions for a big pandemic“

Jordi Esquena – NANBIOSIS U12 Nanostructured liquid characterization unit from IQAC-CSIC and CIBER-BBN with “Play as you know? How “kill” the virus“

The European Researchers’s Nigth is a project founded by the European Commission (Horizon 2020 project EuNightCat-954506) with the aim of familiarizing the public with the research developed in Europe.

Further information:

ICMAB-CSIC

IQAC-CSIC

MSCA and Citizens page

lanitdelarecerca.cat

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European Biosensor Symposium digital seminars, co-organized by Pilar Marco

Pilar Marco, the Scientific Director of NANBIOSIS U2 , Custom Antibody Service (CAbS), and leader of the group Nanobiotechnology for Diagnostics (Nb4D) from CIBER-BBN and IQAC-CSIC, coorganises the European Biosensor Symposium digital seminar series.

The aim of these seminar series is to continue with the purpose of the European Biosensor Symposium, held in March 2021, to allow especially juior reseachers to present their research, exchange ideas and built networds.

The seminars are scheduled on the third Tuesday of every month at 18:00 CET, via zoom. Each of the seminars is organized by a host focussing on a specific topic:

  • “Interferometric sensors“, hosted Claudia Pacholski, University of Potsdam, 15th June
  • “Emerging biosensor technologies“, hosted by Yi Sun, DTU Health Tech, 17th August
  • “Raman – Based Biosensors“, hosted by Dana Cialla May, LEibniz Institute of Photonic Tecnology. 21th September
  • “Emerging trends in Bioelectronics“, hosted by Larysa Baraban, Helmholtz Center Dresden, 19th October
  • “Nanobodies for Biosensing” hosted by J.Pablo Salvador, CIBER-BBN, 16th November
  • “Microbial Biosensors” hosted by Galina Pankratova, DTU Health Tech, 21th December

Each seminar with one invited speaker, three graduate student speaker and up to five graduate student poster presenters.

Registration is free writting an e-mail to the corresponding hots of each session.

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Five experts explain the results of the CSIC Global Health Platform after a year of research on the SARS-CoV-2 coronavirus

– Margarita del Val, Pilar Marco, Mario Mellado, Diego Ramiro and Iñaki Comas will disseminate, in a webinar through YouTube, the works on the disease, diagnosis and social impact
– The platform investigates the new coronavirus in six areas: prevention, disease, containment and diagnosis, treatment and vaccines, social impact and communication

Five experts from the Higher Council for Scientific Research (CSIC) will explain in a webinar broadcast on YouTube, on Wednesday, May 5 at 6:00 p.m., the results of a year of research at the CSIC on the SARS-CoV-2 coronavirus carried out by the Global Health Platform. In the session, titled El CSIC y la covid-19. A year later, five coordinators of the platform will participate: the virologist and immunologist Margarita del Val, from the Severo Ochoa Molecular Biology Center (CBMSO-CSIC-UAM), who will moderate the debate; the nanobiotechnologist Pilar Marco, who leads the group Nb4D of CIBER-BBN/IQAC-CSIC and Scientific Director of NANBIOSIS unit 2Custom Antibody Service (CAbS); the demographer Diego Ramiro, from the Institute of Economics, Geography and Demography (IEGD-CSIC), the immunologist Mario Mellado, director of the National Center for Biotechnology (CNB-CSIC), and the biologist Iñaki Comas, from the Institute of Biomedicine of Valencia (IBV -CSIC). Interested parties may ask questions via email webinar@csic.es or live through the chat on the CSIC Comunicación YouTube channel.
The CSIC Global Health Platform, launched in March 2020, coordinates more than 100 projects to unravel the new coronavirus and seek medium and long-term solutions. The platform has mobilized and coordinates more than 300 research groups from more than 90 CSIC centers, out of a total of 120, in six work topics, which try to cover all aspects of the pandemic with an interdisciplinary approach: prevention, prevention, disease, containment and diagnosis, treatment and vaccines, social impact, and communication.
The platform has coordinated 100 research projects and actions, ranging from the development of antivirals and anti-inflammatory treatments, the monitoring of transmission, the study of the virus genome and the impact of mutations, the genetics of patients, their immune response to infection and vaccination, up to the launch of systems for diagnosis and containment of the virus.
The platform has also included studies carried out on the social perception of the measures, especially on the impact on nursing homes.

The Global Health platform has become a stable structure for scientific cooperation, as well as for the generation of patented technologies. Its consolidation, reinforcing its structure and coordination mechanisms, in particular the link with the clinical sector, prepares the body to face new challenges and opportunities, and for the development of initiatives with companies in Spain, necessary to configure a response to this and future pandemics.


The speakers
Margarita del Val (CBM-CSIC-UAM) is a virologist and immunologist. She coordinates the CSIC Global Health Platform, where she directs a project to characterize the immune response to infection by the SARS-CoV-2 virus and to vaccination.
Pilar Marco (IQAC-CSIC) is a nanobiotechnologist. She runs a project (POC4COV) to develop rapid detection tests for the coronavirus. The objective is to obtain low-cost tests to detect biomarkers of the virus using electrochemical technology and nanostructures.
Mario Mellado (CNB-CSIC) is an immunologist and directs the CSIC’s National Center for Biotechnology, which has become the agency’s center on research into treatments for the SARS-CoV-2 coronavirus. At the CNB-CSIC, two vaccine prototypes for covid-19 and treatments with monoclonal antibodies are being developed, and drugs with possible efficacy to treat the new coronavirus are being screened.
Diego Ramiro (IEGD-CSIC) is a demographer and directs three projects to assess the impact of the covid-19 pandemic on residences for the elderly.
Iñaki Comas (IBV-CSIC) is a biologist and an expert in genomics. He co-leads a genomic epidemiology project on the evolution of SARS-CoV-2 in Spain. His team has observed that there were multiple introductions of SARS-CoV-2 in Spain, but that only a few caused a large number of infections.

Source of information: CSIC

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A GLOBAL VISION OF THE COVID-19 PANDEMIC by CSIC

A report from the Spanish National Research Council (CSIC) collects in open access the results of a year of research on SARS-CoV-2. The book ‘A global vision of the COVID-19 pandemic’ shows the responses and solutions obtained by the 300 research teams of the CSIC Global Health Platform. The Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) has participated in the preparation of the chapter ‘Actions in containment and diagnosis’:

Visit CSIC website to read the full news.

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NANBIOSIS Scientific Women in the International Day of Women and Girls in Science

Today February 11 is the International Day of Women and Girls in Science, a day to raise awareness of the gender gap in science and technology.

According to the United Nations, while yet women and girls continue to be excluded from participating fully in science, science and gender equality are vital to achieve the internationally agreed development goals, including the 2030 Agenda for Sustainable Development. Thus, in recent years, the international community has made a great effort to inspire and promote the participation of women and girls in science.

NANBIOSIS wants to acknowledge  the efforts made by scientific women who struggle every day to contribute their bit to Science and highlight their essential role in nowadays research. Especially we want to recognize the work of scientists women involved in NANBIOSIS, whatever is the nature of their contribution: technical, scientific development, management, coordination, direction, etc; just to mention some examples:
Neus Ferrer and Mercedes Márquez in the Scientific Direction and Coordination of Unit 1 Protein Production Platform (PPP)
Pilar Marco and Nuria Pascual in the Management and Scientific Coordination of U2 Custom Antibody Service (CAbS) 
Miriam Royo in the Scientific Direction of U3 Synthesis of Peptides Unit
Nora Ventosa and Nathaly Segovia in the Scientific Direction and Technical Coordination of U6 Biomaterial Processing and Nanostructuring Unit
Isabel Oliveira and Teresa Galán in the Coordination of U7 Nanotecnology Unit
Rosa Villa and Gemma Gabriel in the Management and Scientific Coordination of U8 Micro – Nano Technology Unit
Gema Martínez in the Scientific Coordination of U9 Synthesis of Nanoparticles Unit
Fany Peña in the Scientific Coordination of U13 Tissue & Scaffold Characterization Unit
Mª Luisa González Martín and Margarita Hierro in the of Direction and Scientific Coordination of U16 Tissue & Scaffold Characterization Unit
Gemma Pascual and Isabel Trabado in the Coordination of the U17 Confocal Microscopy Service
Isolda Casanova in the Scientific Coordination of U18 Nanotoxicology Unit
Beatriz Moreno in the Scientific Direction of Unit 19 Clinical tests lab
Ibane Abásolo in the Scientific Coordination of Unit 20 In Vivo Experimental Platformt
Verónica Crisóstomo in the Scientific Direction of Unit 24 Medical Imaging 
Ana Paula Candiota in the Scientific Coordination of Unit 25 Biomedical Applications I 
Maria Luisa García in the Scientific Direction of U28 NanoImaging Unit from Bionand, recently incorporated to NANBIOSIS, Anna Aviñó in the Scientific Coordination of U29 Oligonucleotide Synthesis Platform (OSP) – and

Nerea Argarate in the coordination of NANBIOSIS

Thanks to all of you and your teams!

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NANBIOSIS Unit 2 obtains the Biosafety Level 2 Accreditation

The laboratory of NANBIOSIS Unit 2 from IQAC-CSIC and CIBER-BBN has obtained the biosafety level 2 accreditation, which allows the laboratory to work with biological agents classified in the risk group 2.

Biological containment level 2 (NBS2) laboratories are generally required to work with any derivative of human blood or other primates, body fluids (especially when they are visibly contaminated with blood), cell lines, or tissues in which has uncertainty about the presence of an infectious agent.

Also, the group participates in the COVID project “Point-of-care tests for the rapid detection of SARS-CoV-2 (POC4CoV)”, funded by the CSIC. This project involves the handling of swabs and serum samples from both positive and negative SARS-CoV-2 patients. Lluïsa Vilaplana, member of research group Nb4D of CIBER-BBN and IQAC-CSIC, led by Dra. M. Pilar Marco, wich Coordinates NANBIOSIS U2, has coordinated the process to obtain the accreditation.

The laboratory has an antechamber or clean locker room, a card-controlled entry system and a space for the storage of materials and reagents. It has also an independent air conditioning system, a specific air renewal system and a biosafety cabin type 2A, with HEPA filter. In addition, it is equipped with a suitable lighting system, an emergency lighting system and a large observation peephole on the door.

In addition to this specific equipment, the laboratory is equipped with an inverted microscope, centrifuge, thermostatic bath, stirrers, incubators, refrigerator and autoclave for sterilization and waste management.

The Nanobiotechnology for Diagnosis (Nb4D) research group , focus the research on the development of biomarkers for the diagnosis of infectious diseases. Nowadays, the group participates in five research projects related to this topic. These projects involve working with clinical samples for the detection of the pathogens Pseudomonas aeruginosa (Gram – type bacteria) and Staphylococcus aureus (Gram + type bacteria), both classified in risk group 2.

Source of information: IQAC-CSIC Communication

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Highly sensitive monoclonal antibodies for a new biosensor for hormones detection in fertility treatments

Nb4D research group and NANBIOSIS U2 Custom Antibody Service (CAbS) of CIBER-BBN at the IQAC-CSIC, together with the company Droplite Technologies have obtained a Retos-Collaboration project funded by the Ministry of Science and Innovation, for the development of a biosensor for detection and rapid quantification of hormones, linked to in-vitro fertility treatments.

NANBIOSIS U2 CAbS will be responsible for the production of highly sensitive monoclonal antibodies, counting on the experience in this field of Juan Pablo Salvador, project coordinator, Núria Pascual and Mª Pilar Marco.

The measurement of the hormone estradiol is a key indicator, both of maturity and of the degree of ovarian stimulation, very important in a successful fertilization process. But there are no tools that allow accurate and sensitive monitoring.

Thus, the consortium formed by Nb4D-Droplite proposes as a solution a new device to perform the control and quantification of hormones, in particular estradiol, in less than 30 minutes, without the need for a central laboratory and only using a drop of blood, which is obtained simply by pricking the patient’s finger.

With funding of € 388,531, the project strategy consists of a transversal collaboration between the Droplite company and the CIBER-BBN research center, through the Nb4D group, supported by the Hospital Clínic de Barcelona, ​​which allows a continuous evaluation and optimization of the prototype based on the exchange of experiences and knowledge.

On the other hand, Droplite, led by its co-founders André Guedes and Rafael Porcar, contributes its experience in the development of an optical detection system based on nanotechnology, which will allow to detect and monitor, automatically and quantitatively, different markers and provide results in just 10 minutes. Droplite is dedicated to the biotechnology sector that emerged as a spin-off of the Institute of Photonic Sciences (ICFO)

The call Retos Colaboración

The aid of this call, managed by the Ministry of Science and Innovation and the State Research Agency, aims to support experimental development projects in cooperation between companies and research organizations, in order to promote the development of new technologies, business application of new ideas and techniques, and contribute to the creation of new products and services.

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Nb4D group- NANBIOSIS U2 receives the acreditation TECNICO, in the on line event organizes by ACCIO

Las November 27 was held the ACCIO ceremony (on line this year due to the Covid Pandemic restrictions) of disclosure of new TECNIO accreditations.

Aurea Rodriguez, Director of Business Innovation at ACCIO has welcomed the attendees to the event. Later, the TECNIO program Coordinator, Marta Peidro, presented the background and rationale for this accreditation for excellence groups in technology transfer in Catalonia. This year there have been five new groups from among all Catalan universities and research organizations, which have obtained the TECNIO accreditation for the first time, making a total of fifty-four groups accredited in 2020.

The event continued with the presentation of the five new accredited groups, starting with the IQAC-CSIC – CIBER-BBN Nb4D group, coordinator of NANBIOSIS unit 2 Custom Antibody Service (CAbS) that investigates improvements to current clinical diagnostic methods.

After the presentations of the five new groups, the tools and benefits that ACCIO offers to TECNIO groups were explained and the event ended with a round of questions from the attendees, such as what will be the future financing strategy of ACCIO for TECNIO groups or how has it been the response to the recent call for INNOTEC grants

As expressed by Prof M. Pilar Marco: “This seal recognizes us as a tech-transfer agent with distinguishing technological capabilities and increases our visibility in front of the business world.”

ACCIÓ is the agency set up by the Catalan Government to make Catalan enterprise more competitive throughout the world. Its key aims are to drive innovation, internationalisation and attract inward investment. ACCIÓ is enterprise-centred, working on the needs of each individual business and to work hand in hand to look for opportunities and achieve that all important competitive edge. At ACCIÓ we believe this edge can come about with work on three vital areas of competitive dynamics: innovation, internationalisatio, attraction of investment. ACCIÓ is a proactive agency, with a simple, clear and efficient modus operandi, above all dedicated to working in close quarters with enterprise. ACCIÓ is based in Barcelona with an international network of a further 35 Business Promotion Centres covering some 80 markets worldwide. It provides advice and practical help for businesses with a vocation to expand worldwide. It focuses on attracting inward investment into Catalonia and also works on synergies between R+D+i areas and business.

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Nb4D group – NANBIOSIS Unit 2 CAbS – accredited with the TECNIO seal

The Nb4D group of CIBER-BBN and IQAB-CSIC, coordinator of NANBIOSIS Unit 2 Custom Antibody Service (CAbS), has been accredited with the TECNIO seal.

This accreditation is the hallmark TECNIO granted by the Government of Catalonia, through ACCIÓ, to identify the developers and facilitators of differential technologies in Catalonia. TECNIO is the umbrella brand for catalan technology centres and university research groups dedicated to industrial research and technology transfer.

ACCIO, CERTIFICATION, QUALITY MANAGEMENT SYSTEM

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