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News U7

News U7

The Scientific Director of NANBIOSIS Unit 7, awarded with the Narcís Monturiol medal for his contribution to science and technology

The Catalan Government announced yesterday the Narcís Monturiol Medal award for scientific and technological merit to the Director of NANBIOSIS Unit 7 Nanotechnology Unit from CIBER-BBN and IBEC, Josep Samitier Martí, for his contribution to the development of the Catalan system of science and technology.

The Narcís Monturiol Prize was established by the Generalitat of Catalonia in 1982, in honor of the Catalan scientist and inventor Narciso Monturiol, to award the people and entities that have made an outstanding contribution to the scientific and technological progress of Catalonia.

It is awarded in the form of medals and plaques. The medals are awarded to individuals, and the plates to legal entities.

This year, ten researchers from the Catalan knowledge system have received this distinction (Ramon Brugada and Terradellas, Paul Christou, M. Teresa Espinal and Farré, Manel Esteller, Pilar García Almirall, Paloma Mas, Victoria Reyes García, Jordi Salas-Salvadó, Josep Samitier and Martí and Sebastián Xambó Descamps), also the Institute of Photonic Sciences (ICFO) has received the Narcís Monturiol Plate, which recognizes an institution of the country.

For further information here

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NANBIOSIS researchers featured in the 15th Edition of Spanish Researchers Ranking

The 15th edition of the Webometrics Ranking of World Universities has been published, ranking researchers in Spain as well as Spaniards doing research abroad. A total of 11 Directors of NANBIOSIS units appear on the most recent list, featured on the top 2000. The list is ordered by the h-index, a metric that calculates research impact based on a correlation of papers published and number of citations, and then by number of citations. The result is a list of whose’s publications have had more impact online.

NANBIOSIS researchers featured are Fernando Albericio (#207), scientific director of U3 Synthesis of Peptides Unit, Ramón Martínez Máñez (#342) U26 NMR: Biomedical Applications II, Jaume Veciana (#459) U6 Biomaterial Processing and Nanostructuring Unit, José Luis Pedraz (#906) U10 Drug Formulation unit, Jesús Santamaría (#912) U9 Synthesis of Nanoparticles Unit, Ramón Eritja (#1022) U29 Oligonucleotide Synthesis Platform (OSP), Pablo Laguna (#1153) U27 High Performance Computing, Antoni Villaverde (#1249) U1 Protein Production Platform (PPP), Laura Lechuga (#1511) U4 Biodeposition and Biodetection Unit M.Pilar Marco (#1517), U2 Custom Antibody Service (CAbS), and Josep Samitier (#1836) U7 Nanotechnology Unit.

This list reflects on the impact online publication can have as a tool to share knowledge. 

For further information: here

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“Tips and tricks to achieve good results at the bench”

The IBEC Core Facilities team, coordinating NANBIOSIS U7 Nanotechnology Unit has celebrated the 6th edition of the Workshop “Tips and tricks to achieve good results at the bench”.

This workshop is focused on fundamental basic aspects of working in a Chemistry/Biology laboratory: process of performing an experiment, from previous planning until the moment of leaving the bench.

The workshop was divided in two parts:

  • Introduction and overview to the Good Laboratory  Practices.
  • Highly interactive and practical daily lab situations with real equipment.

Upon completion of this workshop participants are able to understand the basics of good laboratory practices, plan an experiment taking into account all the steps necessary to perform it, use several basic equipment (scale, centrifuge, pHmeter, biosafety cabinet/sterile technique, handing liquids) and classify several types of hazardous waste.

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Agreement signed with MINECO for the allocation of FEDER funds for NANBIOSIS ICTS

In the framework of the FEDER Program in ICTS 2014-2020, a project related to the ICTS NANBIOSIS has been selected by the Ministry of Science, Innovation and Universities for co-financing with FEDER funds of the European Regional Development Funds program.

An agreement has been signed between the Ministry of Science, Innovation and Universities and the Institute of Bioingeniería of Catalonia (IBEC) for the implementation of the project “Mask Aligner Team for the unit of Nanotechnology (U7) of Nanbiosis” cofinanced by FEDER Performance Program 2014-2020.  The total budget of the project amounts to € 117.000, with 50% financing with FEDER Funds.

IBEC isprocessing the necessary contracting procedures for the execution of this project.

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NANBIOSIS Scientific Women in the International Day of Women and Girls in Science

Today February 11 is the International Day of Women and Girls in Science, a day to raise awareness of the gender gap in science and technology.

According to the United Nations, while yet women and girls continue to be excluded from participating fully in science, science and gender equality are vital to achieve the internationally agreed development goals, including the 2030 Agenda for Sustainable Development. Thus, in recent years, the international community has made a great effort to inspire and promote the participation of women and girls in science.

NANBIOSIS wants to acknowledge  the efforts made by scientific women who struggle every day to contribute their bit to Science and highlight their essential role in nowadays research. Especially we want to recognize the work of scientists women involved in our units, whatever is the nature of their contribution: technical, scientific development, management, coordination, direction, etc; just to mention some examples:
Neus Ferrer in the Scientific Direction of Unit 1 Protein Production Platform (PPP)
Pilar Marco and Nuria Pascual in the Management and Scientific Coordination of U2 Custom Antibody Service (CAbS) 
Miriam Royo in the Scientific Direction of U3 Synthesis of Peptides Unit
Laura Lechuga and M.Carmen Estevez in the Direction and Scientific Coordination of U4 Biodeposition and Biodetection Unit
Nora Ventosa and Nathaly Segovia in the Scientific Direction and Technical Coordination of U6 Biomaterial Processing and Nanostructuring Unit
Isabel Oliveira and Teresa Galán in the Coordination of U7 Nanotecnology Unit
Rosa Villa and Gemma Gabriel in the Management and Scientific Coordination of U8 Micro – Nano Technology Unit
Gema Martínez in the Scientific Coordination of U9 Synthesis of Nanoparticles Unit
Fany Peña in the Scientific Coordination of U13 Tissue & Scaffold Characterization Unit
Mª Luisa González Martín in the of Direction and Scientific Coordination of U16 Tissue & Scaffold Characterization Unit
Gemma Pascual and Isabel Trabado in the Coordination of the U17 Confocal Microscopy Service
Mª Virtudes Céspedes in the Scientific Coordination of U18 Nanotoxicology Unit
Beatriz Moreno in the Scientific Direction of Unit 19 Clinical tests lab
Ibane Abásolo in the Scientific Coordination of Unit 20 In Vivo Experimental Platformt
Verónica Crisóstomo in the Scientific Direction of Unit 24 Medical Imaging 
Ana Paula Candiota in the Scientific Coordination of Unit 25 Biomedical Applications I 
Maria Luisa García in the Scientific Direction of U28 NanoImaging Unit from Bionand, recently incorporated to NANBIOSIS

Thanks to all of you and your teams!

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STRYKER & NANBIOSIS start a promising line of biomedical research collaboration

On January 23-24th a two-day meeting between NANBIOSIS and Stryker Trauma GmbH, took place at the Carlos III Health Institute, in Madrid, to explore synergies and potential joint initiatives.  

Nils Reimers and Robin Buescher from Stryker, presented some of their research and upcoming projects in the field of trauma medical devices, and representatives from NANBIOSIS’ units -Marisa González from U16 Surface Characterization and Calorimetry Unit, Teresa Galán from U7, Nanotechnology Unit, Gemma Pascual from U17 Confocal Microscopy Service, from CIBER-BBN, Marisa García from U28 (Bionand) and José Francisco Guillén and Francisco Sanchez Margallo from the units of the Jesús Usón Minimum Invasive Surgery Center (CCMIJU) , together with Jesús, Izco Executive Director of NANBIOSIS and Ramon Martínez, Scientific Director of CIBER-BBN- explained their technologies.

The second day, the meeting location was moved to the CCMIJU in Cáceres, to visit the Center facilities and continue conversations.

All attendees expressed their satisfaction with the development of the meeting and agreed to continue with the explorations in forthcoming meetings.

Photo caption: From left to right: José Francisco Guillén (Quality Guarantee Manager of CCMIJU),  Jesús Izco (NANBIOSIS Executive Director), Francisco Sanchez Margallo (Scientific Director of CCMIJU), Nils Reimers (Senior Manager R&D – Stryker Trauma GmbH), Robin Buescher (Director R&D Stryker Trauma GmbH), Margarita Casado (Management Staff of NANBIOSIS)”

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Nanopatterns of Surface-Bound EphrinB1 Produce Multivalent Ligand–Receptor Interactions That Tune EphB2 Receptor Clustering

Researchers  of NANBIOSIS U7. Nanotechnology Unit, are coauthors of the article “Nanopatterns of Surface-Bound EphrinB1 Produce Multivalent Ligand–Receptor Interactions That Tune EphB2 Receptor Clustering” published by NanoLetters, ACC Publications.

The authors present a nanostructured surface able to produce multivalent interactions between surface-bound ephrinB1 ligands and membrane EphB2 receptors. They have created ephrinB1 nanopatterns of regular size (<30 nm in diameter) by using self-assembled diblock copolymers. Next, they have used a statistically enhanced version of the Number and Brightness technique, which can discriminate—with molecular sensitivity—the oligomeric states of diffusive species to quantitatively track the EphB2 receptor oligomerization process in real time. The results indicate that a stimulation using randomly distributed surface-bound ligands was not sufficient to fully induce receptor aggregation. Conversely, when nanopatterned onto our substrates, the ligands effectively induced a strong receptor oligomerization. This presentation of ligands improved the clustering efficiency of conventional ligand delivery systems, as it required a 9-fold lower ligand surface coverage and included faster receptor clustering kinetics compared to traditional cross-linked ligands.

In conclusion, nanostructured diblock copolymers constitute a novel strategy to induce multivalent ligand–receptor interactions leading to a stronger, faster, and more efficient receptor activation, thus providing a useful strategy to precisely tune and potentiate receptor responses. The efficiency of these materials at inducing cell responses can benefit applications such as the design of new bioactive materials and drug-delivery systems

Article:

Nanopatterns of Surface-Bound EphrinB1 Produce Multivalent Ligand–Receptor Interactions That Tune EphB2 Receptor Clustering. Verónica Hortigüela, Enara Larrañaga, Francesco Cutrale, Anna Seriola, María García-Díaz, Anna Lagunas, Jordi Andilla, Pablo Loza-Alvarez, Josep Samitier, Samuel Ojosnegros, and Elena Martínez. Nano Letters 2018 18 (1), 629-637 DOI: 10.1021/acs.nanolett.7b04904

 

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Josep Samitier, Scientific Director of NANBIOSIS Unit 7, Panelist in a round table about the current situation of biomedical research

Last month NANBIOSIS Unit 7 Nanotechnology Unit Scientific Director Josep Samitier was one of the panelists in a round table organised by the Cercle de Salut, an association devoted to improving the health system so that it may respond adequately to the challenges posed by society.

In the discussion at the Parc de Recerca Biomèdica de Barcelona (PRBB) entitled ‘L’excel·lència en la recerca, reptes immediats’, Josep and the other participants – ISGlobal director Antoni Plasencia and IrsiCaixa director Bonaventura Clotet – discussed the current situation of biomedical research in Catalonia. In particular, the hot topic under discussion was the impact that recent regulatory and administrative changes may have on its competitiveness.

Samitier is a key figure of influence in this area, not only as president of ACER (the Associació Catalana d’Entitats de Recerca, but also with IBEC being a member of SOMMa, the alliance of the country’s 41 Severo Ochoa and María de Maeztu units. One of SOMMa’s first actions was the document ‘Informe SOMMa: Acciones necesarias para salvaguardar la competitividad de la ciencia’ to attract the attention of politicians to address some of the problems currently hampering research in the country, such as VAT deduction, public contracting, and the hiring of personnel.

The proceedings began with a presentation of the document on behalf of SOMMa by Bruna Vives, managing director of the CRG, and the round table moderator was Jordi Camí, director general of the PRBB and the Fundació Pasqual Maragall. The session was closed by Cercle de Salut vicepresident Lluis Bohigas.

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«The combination of nanotechnology with bioengineering and biomedicine allows us to act on the human body on a molecular scale»

Josep Samitier, Scientific Director of NANBIOSIS Unit 7 Nanotechnology Unit, has been highlighted in ‘Dominical’ supplement of the Diari de Girona last week.

More information here 

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NANBIOSIS U7 Scientific Director, J Samitier and his vision on technology as a source of eternal youth

Josep Samitier, Scientific Director of U7 of NANBIOSIS, Nanotechnology Unit, has been recently featured in an article in the Jornal “El Mundo”

Following the publication of the book “The Death of Death” by Jose Luis Cordeiro and David Wood, which says that by 2045 death will optional thanks to new technologies finding a way to cure aging, the article interviewed Josep Samitier, to have a more realistic point of view.

The book ‘Death of death’ assures that in 2045 die will be something optional thanks to the new technologies will find a way to cure aging based on success examples of regenerative medicine, stem cell treatments, therapies genetics, 3D printing of organs or bioengineering, that in approximately 30 years aging will be a curable disease, that young indefinite longevity will be achieved, or, in other words, the possibility of being young indefinitely and that death will be, defect, something optional.

José Luis Cordeiro, co-author of the book goes back to 1950 to remember that it was there when it was discovered that the problem of cancer is that it is biologically immortal. They are, in the same way, germ cells or some stem cells, present in all organisms. “What we did not have before is the technology we have today, which allows us to detect the genetics of these cells, when the body dies, the germ cells, the mother and the cancer die, because the food ends, but if they are isolated and they are kept in the right environment, these cells are kept alive permanently”. So, his proposal is to investigate what determines that these are immortal cells and try to imitate the process to find the way that this affect our aging until it stops.

Dr. Angel Raya, Principal Investigator of the CIBER-BBN in the Center of Regenerafiva medicine of Barcelona clarifies that “the diseases that affect us in relation with aging are diseases in which the symptom is produced by the failure of one of the parts of the system, the idea is that if we recover the function of that part in a functioning system, the patient will not have that disease, but that does not mean that he will have more life”.

According to Josep Samitier, “there are fundamental problems associated with aging, such as the loss of muscle mass, the loss of certain capacities …, the human being has cells that are born, develop, die and they are replaced by others, but as we gain years, the replacement stops occurring, understanding. Well this, that does not happen and is maintainance is much more complicated”. In short, the experts consulted affirm that the human body is not reduced to the parts or organs that make it up, and that fixing its mechanical failures will not result in lengthen life indefinitely. “A house made of billets can crumble, but the materials that constituted it, the iron and silicon atoms that form the sand and the iron beams will remain there even if the house disappears,” continues Samitier, “In the same way, we are made up of water, carbohydrates, fats …, the atoms of these substances endure and are quite immortal, but we have to think about the organization of this system, and what we see is that it is something difficult to maintain in a functional way for many years. Advances in bioengineering will help us to live longer and with better quality of life, we will solve some issues and we will have options to fix hearts after heart attacks and things like that, but the problem is not that one thing fails, it is that several fail”.

Article

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