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New NANBIOSIS’ focus on Cutting-Edge Biomedical Solutions

We are delighted to announce the publication of our new corporate brochure which reflects NANBIOSIS’s main core competences. This fresh looking promotion material has been intentionally designed to emphasize our experience of join expertise and capabilities solving problems in biomedical research, focussing on quality, adaptability and excellence commitment.

The NANBIOSIS’ Cutting-Edge biomedical solutions  have been updated to offer a wider range of Integrated solutions to advanced challenges faced by biomedical researchers in the fields of tissue engineering, regenerative medicine, diagnostic and medical devices.

The Cutting-Edge biomedical solutions offered by the ICTS NANBIOSIS have been organised drilling down on our key areas:

  • Customized biomolecules production & Validation
  • Customized nanomedicines production & Preclinical Validation
  • Customized biomaterials production & Preclinical Validation
  • Diagnostic Devices production & Validation

Downloadable PDF of the brochure is here available

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NANBIOSIS participates in a transversal action of CIBER incorporated into the Biobanks and Biomodels Platform of the Carlos III Health Institute

Recently, a transversal action of CIBER has been started, coordinated by Cristina Villena, made up of teams from 4 thematic areas of the CIBER (CIBERES, CIBERER, CIBER-BBN and CIBERONC) that has constituted a unit of the CIBER that has been incorporated into the new Platform of Biobanks and Biomodels of the Carlos III Health Institute (ISCIII).

The CIBER unit has been selected in the call for ISCIII Platforms to support R+D+I in Biomedicine and Health Sciences of the Strategic Action in Health 2017-2020, which will finance the Platform of Biobanks and Biomodels and two more platforms on support to clinical research and revitalization of the industrial capacities of the National Health System.

This transversal unit of the CIBER, which is one of the 41 units that will be part of the Biobanks and Biomodels Platform, will be financed with more than 130,000 euros over the next three years.

The ISCIII Biobanks and Biomodels Platform (2021-2023) will coordinate the supply of biological samples of conventional diseases through the creation of virtual biobanks, and in turn, will develop the provision of services in the field of organoids, animal models and 3D printing of tissues.

The CIBER unit initially involved, (due to their long experience in providing services), the CIBER Pulmonary Biobank Platform for Respiratory Diseases (PBP CIBERES), with 12 years of operation; the CIBER Biobank of Rare Diseases (CIBERER Biobank, CBK), with 9 years; the Mouse Embryo Cryopreservation Service (CRIOCNB) and Histology (HISTOCNB) of the CIBERER (CNB-CSIC) with 16 years; and the Non-Invasive Neurofunctional Evaluation Service (ENNI) of the CIBERER (Institute of Biomedical Research “Alberto Sols” (IIBM-CSIC / UAM)) with 14 years; as well as the ICTS NANBIOSIS platform of the CIBER for Bioengineering, Biomaterials and Biomedicine (CIBER-BBN) with 8 years and the work modules of the Center for Biomedical Research in Cancer Network (CIBERONC).

This initiative, based on the collaborative work of several thematic areas of the CIBER, has as main objectives: (i) to create a CIBER catalog of biological samples and biomodel services available to consultable R + D + i, and with a common integrated management to be able to develop a CIBER Virtual Biobank; (ii) identify new existing biomodels at the CIBER, as well as technical capabilities and services that may be of interest, which can also be offered to researchers outside the institution itself; and (iii) create alliances with other similar structures to harmonize procedures and processes in the provision of research services.

“Without a doubt, this platform will improve the visibility, performance and offer of all the existing bio-resources and research support services at the CIBER, which will contribute to improving collaboration between researchers, the quality of research, as well as the transfer to the clinical practice and the productive sector ”, according to Cristina Villena

ISCIII platforms

The ISCIII Platforms are a set of research centers and groups that share their high-level scientific-technical capacities with research groups of the National Health System (SNS), and with a clear orientation to health sciences, to patients and their families, with the aim of making Spanish groups more competitive in the new Horizon Europe program.

In the 2020 call, the ISCIII has financed the Biobanks and Biomodels Platform and 2 more platforms, the Support Platform for Clinical Research and a platform that will facilitate the industrialization of the developments and research of the National Health Service, with a Global financing for the three platforms of 27 million euros to be executed during 2021-2023.

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Agreement signed with Spanish Government for the allocation of FEDER funds for NANBIOSIS ICTS units at JUMISC

In the framework of the FEDER Program in ICTS  2019 14 50, a project related to the ICTS NANBIOSIS has been selected by the Ministry of Science, Innovation and Universities for co financing with FEDER funds of the European Regional Development Funds program.

An agreement has been signed between Ministry of Science and Innovation and CCMIJU, institution for the co financing of the Project ICTS 2019 14 50 : Genética embrionaria en reproducción asistida (GENERA NANBIOSIS) in Unit 23.

The total budget of the project amounts to € 98.000, with 80% financing with FEDER Funds.

CCMIU is processing the necessary contracting procedures for the execution of this project.

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Agreement signed with Spanish Government for the allocation of FEDER funds for Nanbiosis ICTS

In the framework of the FEDER Program in ICTS 2014-2020, a projects related to the ICTS NANBIOSIS has been selected by the Ministry of Science, Innovation and Universities for co-financing with FEDER funds of the European Regional Development Funds program.

An agreement has been signed between Ministry of Science, Innovation and CCMIJU, institution that houses NANBIOSIS  U14, U19, U21, U22, U23, U24 for the co-financing of the Project ICTS-2019-14-46: “ACTUALIZACIÓN DE LAS INFRAESTRUCTURAS E IMPLEMENTACIÓN DE UN SISTEMA DE CONTROL DOCUMENTAL Y DE GESTIÓN LIMS PARA POTENCIAR LAS CAPACIDADES DE LAS UNIDADES DE LA ICTS DISTRIBUIDA NANBIOSIS (AILIMS-NANBIOSIS)”

 The total budget of the project amounts to € 597.000, with 80% financing with FEDER Funds.

CCMIU is processing the necessary contracting procedures for the execution of this project.

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New equipment for calorimetry and surface characterization for NANBIOSIS U16

NANBIOSIS unit 16 Surface Characterization and Calorimetry Unit form CIBER-BBN and University of Extremadura offers the performance of tasks of physical-chemical characterization of surfaces using techniques such as ellipsometry, calorimetry, X-ray photoelectronic spectroscopy (XPS) and detection of secondary ions by means of mass spectrometry by time of flight (Tof-SIMS). Recently, new equipment acquired through the execution an investment of 1.3 million euros, cofinanced with FEDER funds, the Ministry of Economy and Competitiveness and Junta de Extremadura, Regional Ministry of Economy, Science and Digital Agency, througth the project FICTS1420-14-09. These equipments are a microdroplet and picodroplet contact angle goniometry system and an optical profilometry system.

Equipment acquired

PEAK AND MICRO DROP GONIOMETRY SYSTEM

This system allows to measure contact angles automatically, controlling by software, the deposition of drops of different liquids, their analysis and the orientation of the substrate, as well as pending drops. In addition, the microdroplet system has a tilting base that allows the samples to be tilted by at least 90o. It also includes a thermostatic chamber, for temperature changes of the sample with a range between 5 and 90 ºC, and a chamber for humidity control.

Obtaining surface tension, through contact angle measurements, is a factor to consider in technologies of biomedical interest such as implants and other materials that must be in contact with biological fluids. In these systems the contact angle is related to the wettability, the hydrophobicity of the surface and the adhesion capacity of substances such as proteins or other compounds on the surfaces.

In the case of pico-droplet measurements, the system allows to very precisely dose drops much smaller than in the previous case, which can be as low as 20 picoliters, as well as to analyze their shape to measure the contact angle. This fact solves the problem of measuring wettability in very small structures, such as capillaries, microchips, joints created in the union of two materials, etc.

PROFILOMETRY SYSTEM

The system allows the roughness of a multitude of surfaces to be measured by an optical method that does not make any changes to the sample. With the operating base of a confocal microscope commonly used in different fields of science, it allows to create high-resolution 3D images quickly and automatically, as well as obtaining color images thanks to the use of three LEDs: Red, Green and Blue. With the available objectives, it is possible to measure from more macroscopic samples such as screws used as dental implants to be able to observe bacterial colonies composed of bacteria the size of a micron. This will make it possible to measure the roughness of any sample covering the range of roughness between a magnifying glass, which gives a more macroscopic view, and the atomic force microscope capable of measuring nanometric roughness (10 ^ -9 m). In addition, this equipment also works as an interferometer that allows to measure the roughness with greater precision of mirror polished samples in a simple way, obtaining images of higher resolution than any confocal technique.

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Funded beamtime for SMEs in Sincrotron Alba ICTS thanks to EU CALIPSOplus projec. – Dec. 17 explanatory Webinar Calipsoplus-TamaTA for SMEs

Untill 30 of June 2021, small and medium companies can ask for funded beamtime in different European light sources thanks to EU CALIPSOplus project

The European project CALIPSOplus brings together 19 partners offering access to 14 synchrotrons and 8 FELs in Europe and the Middle East. This pilot transnational access scheme allows SMEs to access the best light source for their particular needs, irrespective of whether or not it is the closest light source.

Leader: CELLS (ALBA Synchrotron) (Barcelona, Spain)

Webpage: https://www.albasynchrotron.es/en/industry/services

Email: industrialoffice@cells.es

On December 17, 2020 – 12:00 – 13:00 Sincrotrón ALBA -ICTS is running a Webinar that will explain to companies how SMEs can benefit from the Calipsoplus-TamaTA project to solve their characterization problems at the ALBA Synchrotron. Inscriptions are open here

NANBIOSIS and SYNCROTRON ALBA, both ICTS facilities established some collaborations in order to increase the scope of the biomedical solutions given to the health sector.

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Two new equipment items at the U6 of Nanbiosis with cofinancing from FEDER funds

The U6 of NANBIOSIS (Biomaterial Processing and Nanostructuring Unit) has expanded its capabilities with 2 new equipment items for the characterization unit. Both equipment items will allow the characterization of some physico-chemical properties of different nanomaterials.

The Zetasizer ULTRA is used to measure the particle size of dispersed systems from sub-nanometer to several micrometers in diameter, using the technique of Dynamic Light Scattering (DLS). Zetasizer systems are also used to analyze particle mobility and charge (Zeta potential) using the technique of Electrophoretic Light Scattering (ELS), and the molecular weight of particles in solution using Static Light Scattering (SLS).

The Green laser module for the NanoSight NS300 equipment. The NS300 allows analysis of the size distribution and concentration of all types of nanoparticles from 0.01 – 1 µm in diameter. This new laser module will allow NTA to measure a range of fluorescent particles, avoiding interferences during the measurements due to sample (auto)fluorescence and absorption.  This is done by detecting the fluorescence signal, which is emitted naturally by particles or as a result of fluorescence labeling or tagging


This equipment have been confinanced by the European Regional Development Fund (ERDF) through the Plurirregional Operational Program of Spain (POPE)2014-2020

European Regional Development Fund
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NANBIOSIS in the new poster of ICTS map published by Spanish Goverment.

ICTS underpins the Spanish reputation for research excellence.

In the picture: the new poster of the ICTS map in which NANBIOSIS facilities have been highlighed with a red square

The term Unique Scientific and Technical Infrastructure (ICTS) refers to facilities, resources, or services for the development of top-quality cutting-edge research, as well as the communication, exchange, and preservation of knowledge, the transfer of technology, and promotion of innovation. They are unique or exceptional in their fields, with a high cost of investment, maintenance, and operation, and are of a strategic importance that justifies their availability to all actors in the field of R&D&I. The ICTS share three fundamental characteristics; they are infrastructures with public ownership, unique and open to competitive access.

ICTS offer an opening capacity percentage of their essential services under ‘Competitive Open Access’ for the use by national and international public and private sector researchers, with the support of technical and administrative personnel of the ICTS. Infrastructures access is ruled by a public “Access Protocol” that describes the procedure and criteria for access to the infrastructure. The main features of ‘Competitive Open Access’ are that R + D + i quality of activities developed at the infrastructure should be proven and that requests for access should be prioritized on the basis of objective criteria.

The dissemination of ICTS and their capabilities is essential to provide Spanish and international researchers with access to a large base of quality services and facilities, a basic requirement for the development of excellent science.

The new posster pushised by the General Subdirectorate of Large
Scientific-Technical Facilities of the of the Sapanish Ministry of Science and Research Innovation helps to disseminate and understand the map of ICTS wich are located throughout the country

NANBIOSIS, is one of the five ICTS in the field of Health Sciences and Biotechnology

Further informations: MICINN

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Third edition of the course on “Characterization techniques for Particulate Materials” with Amable Bernabé

The Soft Matrials Lab at ICMAB-CSIC, run by Amable Bernabé (NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit, hosted from Monday, 5 October, to Wednesday, 7 October a course on “Characterization techniques for particulate materials”.

The course was an introduction to different techniques to characterize nanoparticles and other particulate matter, including the basic fundamentals, sample preparation, practical examples and results interpretation. 

Due to the COVID-19 pandemic, the participants of the course were less than in previous years, and during the practical sessions the group was divided, so less people was at the same time inside the lab, and the safety measures could be kept. 

Theory:

  • Dynamic Light Scattering (DLS) with Zetasizer Nano ZS (Malvern Instruments)
    • Size distribution
    • Z Potential 
  • Nanoparticle Tracking Analysis (NTA) with Nanosight NS300 (Malvern Instruments)
    • Size distribution
    • Particle concentration
    • Fluorescence
  • Light Scattering (LS) with Mastersizer 2000 (Malvern Instruments)
    • Size distribution

Practice:

  • Sample analysis and practical cases of Dynamic Light Scattering with the Zetasizer Nano ZS (Malvern Instruments) equipment.
  • Samples analysis and practical cases of the Nanoparticle Tracking Analysis (NTA) technique with the Nanosight NS300 (Malvern Instruments) equipment.
  • Sample analysis and practical cases of the Light Scattering (LS) technique with the Mastersizer 2000 (Malvern Instruments) instrument.

Source of information ICMAB-CSIC

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NANBIOSIS in the NEW BOOK of the UNIQUE SCIENTIFIC AND TECHNICAL INFRASTRUCTURES (ICTS)

We are pleased to inform that the new book of Unique Scientific and Technical Infrastructures (ICTS) has been published by the Spanish Ministery of Innovation, Science and Universities with the collaborations of the ICTS.

The Spanish Map of Unique Scientific and Technical Infrastructures (ICTS), goups biomedical technologies, cleanrooms, supercomputers, advanced lasers, telescopes, underground laboratories, synchrotrons, particle accelerators, biological reserves, solar, oceanic and hydraulic platforms, oceanographic research ships, and polar bases in Antarctica. A total of 29 ICTS, made up of 62 nodes, allow for ambitious research projects that attract first-rate talent and enhance the technological and innovative industry capacities.

“Through a one-stop system, NANBIOSIS provides comprehensive solutions that are tailored to the challenges thaat researchers face in biomedicine… its configuration means pioneering multidisciplinary studies can be conducted. Some examples are outlined below.”

NANBIOSIS ICTS

Among these examples, several results combining the expertise of several Units of NANBIOSIS: an original method to prepare smaller nanoparticles of polylactic-co-glycolic acid (PLGA) functionalised with cell-penetrating peptides (CPP), which penetrate the cell membrane and release controlled drug doses into the cells; an innovative medication administration system based on emerging bionanotechnology with protein nanoparticles that selectively deliver lead the therapeutic agent to the tumour cells or a bioactive surgical mesh, covered with adult stem cells, to reduce the inflammatory process associated with implanting this type of material that proved a beneficial effect on the biocompatibility in animal models.

As Pedro Duque, Spanish Minister of Innovation, Science and Universities says in its prelude “The Unique Scientific and Technical Infrastructures described in this book are crucial for Spain and its science, technology, and innovation. I encourage you to browse the pages of this book and discover the state-of-the-art infrastructures that represent the scientific and technological capacity that exists in Spain today. You won’t regret it”

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