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19 Jul

Mechanical Characterization of soft biological tissues - Nanbiosis
Mechanical Characterization of soft biological tissues

The experimental study of the mechanical properties of biological tissues is of vital importance. Thorough research into themechanical response of biomaterials is the basis for the creation ofmodels which can accurately reproduce the mechanical behavior ofsuch materials. Adequate mechanical characterization of tissue materials is of paramount interest to the clinical simulations, diagnostic and tissue engineering fields – where the tissue structure, in contrast to classical mechanics application fields, is just simply a biological tissue. In order to obtain their material properties, classical engineering testing techniques have been applied to biologicalmaterials. To reproduce the mechanical behavior of these kinds ofmaterial, many[...]

16 Jan

U12-Nanostructured liquid characterization unit
Characterization of nanomedicines

The quick development of nanotechnology and its application in medicine have generated new alternatives for the diagnosis and treatment of diseases thanks to the novel methods of preparation, modification and characterization of nanomaterials. The knowledge about the behavior of matter at the atomic and molecular level has allowed the creation of tools and processes to observe manipulate and control biological structures on a scale between 100 and 10,000 times smaller than a mammalian cell. Nanomedicine is defined as the application of nanotechnology in view of making a medical diagnosis or treating or preventing diseases. It exploits the improved and often[...]

News about Nanbiosis

20 Apr

Two Units of NANBIOSIS participates in the CIBERONC – CIBER-BBN collaboratives projects

Scientists from two NANBIOSIS units participate in two of the three projects selected in the Call CIBER-BBN / CIBERONC. On April 13, the 1st CIBERONC – CIBER-BBN Collaborative Projects Forum took place at the National School of Health (Carlos III Health Institute). The purpose of the event was to carry out the resolution of the call for collaborative seed projects between the two areas. During the forum, 12 proposals for collaborative projects were presented, encompassed in four thematic sessions: new nano-devices, new strategies for 3D culture, phototherapy and drug release. All the proposals included the application of some of t[...]

10 Apr

Dr. Simó Schwartz Jr, appointed editor of Precision Nanomedicine magazine

The new magazine “Precision Nanomedicine” in its online version, is about to be issued. Dr. Simón Schwartz Jr, Scientific Director of NANBIOSIS U20 In Vivo Experimental Platform, is one of only two Spanish researchers who are part of the editorial board of the journal. The rest of publishers belong to the United States, Australia, Japan and Europe Precision Nanomedicine is a publication promoted by the European Society of Nanomedicine (ESNAM for its acronym in English), the European Nanomedicine Foundation and the Conference of Clinical Nanomedicine (Clinamen). It was born with the aim of bringing together the most important opinion leaders in this field, disseminating t[...]

22 Mar

NANBIOSIS has presented its nanomedicines Cascade Characterization Model at the IPMT 3rd Workshop

Between today and tomorrow the 3rd workshop of the European project H2020 “IPMT-Integrated Precision Medicine Technologies Center of Excellence” is being held in Barcelona. The meeting is being attended by more than 30 people, from the Fraunhofer Institute for Biomedical Engineering, the CIBER-BBN and the University of Cyprus as well as other partnerts from Cyprus. Jesús Izco, Coordinator of NANBIOSIS has made a presentation of the ICTS and has taken the opportunity to present the NANBIOSIS nanomedicine cascade characterization model, which has aroused great interest among attendees. The objective of the European project “Integrated Precision Medicine Technologies Research Center of Excellence” is to establish an[...]

20 Mar

New book coauthored by Scientists of @NANBIOSIS U25 on Preclinical MRI

Silvia Lope-Piedrafita and Nuria Arias Ramos, Scientists of NANBIOSIS U25 NMR: Biomedical Applications I, have participated as co-authors in chapters of the book “Preclinical MRI – Methods and Protocols“. Editors: María Luisa García Martín y Pilar López Larrubia. This book, also co-authored by other researchers of CIBER-BBN, as Guadalupe Soria y Raul Tudela,  is organized into 7 parts : -Part 1 covers the basics of MRI physics, relaxation, image contrast, and main acquisition sequences; -Part 2 describes methodologies for diffusion, perfusion, and functional imaging; -Part 3 looks at in vivo spectroscopy; -Part 4 explores special MRI techniques that are less known in the field; -Parts 5 and[...]

19 Mar

Ana Paula Candiota member of the Panel of experts from the Autonomous University of Barcelona.

Ana Paula Candiota, Scientific Coordinator of NANBIOSIS U25. NMR: Biomedical Applications I, is now part of the Panel of experts from the Autonomous University of Barcelona. This panel aims to offer their knowledge and experience to the media in case they have questions on specific issues.[...]

16 Mar

IPMT 3rd Meeting with the participation of NANBIOSIS

The CIBER-BBN organizes in Barcelona a WORKSHOP related to the European project H2020 “IPMT-Integrated Precision Medicine Technologies Center of Excellence”, framed within the program “Spreading Excellence and Widening Participation”, in which the scientific direction and scientific committee of the CIBER -BBN, together with the Fraunhofer Institute of Biomedical Engineering (IBMT), participate as reference advisory centers of the University of Cyprus (UCY) and clinical institutions of the country, coordinators of the proposal. Date March 22th-23th, 2018 Location Day 1: IMB-CNM, Campus UAB, Bellaterra, Barcelona, Meeting Room, Jose Millán. Day 2: Hotel Silken Sant Gervasi, Barcelona, Room Garden. IPMT 3 rd Meeting[...]

14 Mar

A new polymeric nomedicin facilitates simultaneous pharmacological and gene silencing therapies

Simó Shwartz, Scientific Director of NANBIOSIS U20 In vivo Experimental Platform, has recently published an interesting article “Efficient EFGR mediated siRNA delivery to breast cancer cells by Cetuximab functionalized Pluronic® F127/Gelatin” issued by  Chemical Engineering Journal. The research group of Dr Schwartz has managed to create a micelle formed by a combination of polymers and gelatin that allows to transport effectively large quantities of both nucleic acids and drugs inside. The system also leads to the periphery a series of carboxylic groups that allow anchoring in a very easy way any type of directing molecule such as for example a peptide or[...]

14 Mar

Influence of polymer concentration on the properties of nano-emulsions and nanoparticles obtained by a low-energy method

Scientists of NANBIOSIS U12. Nanostructured liquid characterization unit have recently published an article in  Colloids and Surfaces A: Physicochemical and Engineering Aspects For further information &nbs[...]

08 Mar

Esther Pueyo closes the series of conferences “Mathematics in our life”

Next Tuesday, March 13, at 7:00 pm, in the facilities of the Social Work of Ibercaja of Patio de la Infanta, the third and last conference of the cycle “Mathematics in our life” will take place, organized by the Royal Academy of Sciences of Zaragoza (RACZ). With the title Mathematics and heart, a tandem with a great future, the last conference will be taught by Esther Pueyo Paules, professor at the University of Zaragoza, researcher at the BSICoS group of CIBER-BBN and I3A of the University of Zaragoza,which coordinates Unit 27 of NANBIOSIS High Performance Computer. Esther Pueyo is winner of a “Starting[...]

07 Mar

NANBIOSIS participated in the Big Science Business Forum 2018 in Copenhagen

During the days 26-28 of February took place in Copenhagen, Denmark the Big Science Business Forum 2018 in which NANBIOSIS was present. Big Science is the term that is used to designate research efforts of great magnitude, due to its high cost, complexity and scientific importance. Scientific progress is increasingly based on large-scale projects, with increasingly global scientific projects and increasingly collaborative research. The Big Science Business Forum 2018 brought together more than 650 delegates from 25 countries, and representatives of more than 250 companies, being an important event to know business opportunities in the coming years as well as to[...]

07 Mar

Numerical models applied to the cornea to improve eye surgery

Researchers of the NANBIOSIS U13 apply numerical models to the cornea to better understand how it behaves and help in surgical planning. Data and algorithms developed through the computer, together with the 3D image, make it easier for ophthalmologists to perform eye surgery more precise and personalized treatments for each patient The work carried out by Miguel Ángel Ariza Gracia at the Aragón Engineering Research Institute (I3A) has been recognized by the University of Zaragoza with the Extraordinary Award for the Best Doctoral Thesis of the Biomedical Engineering Program in 2017 In this line of research, framed in the European[...]

02 Mar

NANBIOSIS Unit 10 of Drug Formulation participates in the European Project Position II

Nanobiocel, the CIBER-BNN – UPV-EHU group, led by José Luis Pedraz, Scientific Director of NANBIOSIS-ICTS U10 “Drug Formulation Unit” participates in the Position II European project, coordinated by Philips Electronics Nederland. The project, funded through the Horizon 2020 call with a global budget of more than 50 million euros, will be developed during three years with the participation of 48 partners. Its general objective is to innovate in the production processes in the field of health to obtain state-of-the-art catheters. It will also include innovative treatments, such as cell therapy, which guide small capsules with cells with a regenerative effect[...]

23 Feb

NANBIOSIS ICTS invites groups and companies to discuss Smart Biomaterials and devices for Drug Delivery

On February 22nd, the National School of Health of the Carlos III Health Institute hosted the forum on Smart Biomaterials and biomedical devices for applications in drug delivery and regenerative medicine, organized by the ICTS Nanbiosis, an infrastructure shared by the CIBER-BBN and the Center of Minimally Invasive Surgery Jesus Usón (CCMIJU). This is the first groups/companies meeting organized by Nanbiosis, in which about 70 B2B meetings  were held. The meeting brought together about 40 participants from 14 research groups (from the CIBER-BBN and the CCMIJU) and 10 companies, which discussed the latest advances in the research lines developed by the groups[...]

06 Feb

NANOMOL, Research Group Coordinator of Unit 6 of NANBIOSIS, accredited with TECNIO certification

NANOMOL, the research group coordinating ICTS “NANBIOSIS” Unit 6, has been accredited with the TECNIO certification as a Technology Developer Organization, until 2019. This TECNIO certification was created by the Government of Catalonia, through ACCIÓ. This certification supports the most qualified agents involved in technology transfer processes, allows companies to access advanced R&D and develop new products and services, and increases the scope of technology projects by finding the most suitable technology partners & suppliers. About Nanomol (ICMAB-CSIC/CIBER-BBN) NANOMOL is a research group depending on the Institute of Material Science of Barcelona from CSIC, with wide expertise and recognized excellence in the synthesis, processing and study of[...]

01 Feb

Microfluidic device that reproduces the blood-retinal barrier

The use of In vitro testing with living cells as an alternative to animal research has limitations like the difficulty to reproduce the interaction of cells. To overcome it, scientists are working on the development of systems that simulate and reproduce functions of tissues and organs in conditions very similar to reality. They are called organ-on-a-chip, which include microenvironments and microarchitectures that simulate the state of tissues and living organs. Scientists of NANBIOSIS Unit 8 have published in an article, cover of the magazine “Lab on a Chip”, the “proof of concept” of a microfluidic device that reproduces the blood-retinal barrier,[...]

25 Jan

Cryopreservation of stem cells

Scientific Reports of the Nature Publications Group has recently published the article ‘Cryopreservation of human mesenchymal stem cells in an allogeneic bioscaffold based on platelet rich plasma and synovial fluid’. This research is part of the doctoral thesis of Haritz Gurruchaga, belonging to the NanoBioCel group of CIBER-BBN and UPV / EHU, which is focused on the optimization of the storage processes of encapsulated cells through slow cryopreservation. The thesis is being co-directed by  José Luis Pedraz and Jesús Ciriza, Scientific Director and Scientific Coordinator of NANBIOSIS Unit 10 Drug formulation. The work is focused on the optimization of the storage processes[...]

25 Jan

Therapeutic approaches with CRISPR for albinism

Preclinical Development of CRISPR- based non-viral therapeutic approaches in existing cellular and animal models of Albinism, (NanoCripsAlbino Therapy)  is a multidiciplinar project to study ways to bring genetic editing tools to target cells to develop therapeutic strategies that can be used to treatment. The project, participated by Lluís Montoliu (CIBERER) and José Luis Pedraz (CIBER-BBN) and will financed by the Internationalization Platform of CIBER-BBN/ER/RES- with € 50000. José Luis Pedraz is the Scientific Director of NANBIOSIS Unit 10 Drug formulation and PI of the CIBER-BBN NANOBIOCELL group, experst in de development of micro and nanoparticles to formulate new active principles[...]

25 Jan

Novel synthetic routes as potential multifunctional theranostic nanodevices

Carlos Rodriguez-Abreu, Scientific Director of NANBIOSIS Unit 12 is co-author of the publication “Novel synthetic routes of large-pore magnetic mesoporous nanocomposites (SBA-15/Fe3O4) as potential multifunctional theranostic nanodevices” by “Journal of Materials Chemistry B”. For further information &nbs[...]

22 Jan

Researchers of NANBIOSIS U3 find activators of a possible therapeutic target for the treatment of patients with diabetes and insulin resistance

Researchers of  NANBIOSIS U3: Synthesis of Peptides Unit participate in the identification of activators of of the mitochondrial protein Mitofusin 2, a possible therapeutic target for the treatment of patients with type 2 diabetes in collaboration with CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM) and the CIBER of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN). Those researchers are led by Fernando Albericio (Scientific Director of Unit 3 of NANBIOSIS) at the University of Barcelona and Antonio Zorzano en el IRB Barcelona  have identified activators of the mitochondrial protein Mitofusin 2 for the treatment of type 2 diabetes. This protein is expressed[...]

18 Jan

ISO 9001:2008 certification of Quality Management System to NANBIOSIS U20

The Area of Functional Validation & Preclinical Research of CIBBIM-Nanomedicine has recently obtained the ISO 9001:2008 certification of Quality Management System. Functional Validation & Preclinical Research (FVPR), led by Dr. Ibane Abasolo, Scientific Coordinator of Unit 20 of NANBIOSIS “In Vivo experimental Platform“,  was created in 2007 as part of the  CIBBIM-Nanomedicine’s technological offer. The objective of FVPR is to provide services to the different research groups of the mother institutions (VHIR and CIBER), as well as to external companies or groups, to evaluate the effectiveness and toxicity of new therapeutic agents or targets, whether they are nanotechnology-based or not. To this end, it has[...]

11 Jan

Improving biomaterials imaging for nanotechnology: rapid methods for protein localization at ultrastructural level

New publication of Tony Villaverde, Scientific Director of Unit 1 of NANBIOSIS acepted by Biotechnology Journal: The preparation of biological samples for electron microscopy is material- and time-consuming because it is often based on long protocols that also may produce artifacts. Protein labeling for transmission electron microscopy (TEM) is such an example, taking several days. However, for protein-based nanotechnology, high resolution imaging techniques are unique and crucial tools for studying the spatial distribution of these molecules, either alone or as components of biomaterials. In this paper, we tested 2 new short methods of immunolocalization for TEM, and compared them with a[...]

29 Dec

Polyurethane and polyurea nanoparticle (PUUa), improves cancer therapy

The national consortium led by the research group of Addressing and Drug Release CIBBIM – Nanomedicine of the Vall d’Hebron Research Institute (VHIR) and led by Dr. Ibane Abasolo, Scientific Coordinataror of Unit 20 of NANBIOSIS, has shown improvement in the effectiveness and specificity of targeted therapy against cancer through the use of polyurethane-polyurea nanocapsules (PUUa), a nanoparticle with a proven targeted release, very useful for drugs with a high level of toxicity and low specificity of distribution. This nanoparticle has been developed by the research section of the Catalan company EcopolTech and Unit 20 of ICTS Nanbiosis has participated in[...]

27 Dec

Conxita Solans receives the lectureship award of the Japan Research Institute of Materials Technology

Prof. Conxita Solans (Nanostructured liquid characterization unit 12 of NANBIOSIS) received the lectureship award of the Japan Research Institute of Materials Technology from Prof. Masahiko Abe, Director of the Institute. Prof. Solans delivered her lecture during the meeting held in Noda (Japan) on December 1st, 2017.[...]

14 Dec

Graphene transistors as eficient transducers for electrocorticography

Researchers of Micro-Nano Technologies Unit (U8) of NANBIOSIS, are co-authors of a new paper published in Advanced Functional Materials. Neuroelectronic interfaces bridge the central nervous system to the outside world and hold great potential for functional restoration in persons with paralysis, other forms of motor dysfunction, or limb loss. Neuroscientists and neurosurgeons are thus looking for technologies that could ideally record the whole brain with a high spatial and temporal resolution. Electrocorticography (ECoG), the practice of placing arrays of large-diameter electrodes (few millimeters) directly on the cortex is the current clinical solution to obtaining brain recordings with high temporal resolution.[...]

30 Nov

The Minimally Invasive Surgery Centre uses HoloLens glasses for medical training and surgical assistance in urology

The Minimally Invasive Surgery Centre, partner of NANBIOSIS,  has developed a software platform to apply mixed reality to medical training and surgical assistance. This will enable the creation of new and more realistic scenarios for medical training and improve surgical results. The Minimally Invasive Surgery Centre (CCMIJU) uses mixed reality technology, by means of the Microsoft’s HoloLens glasses, to help train future healthcare professionals and provide an assistance tool for complex surgeries. The institution located in Cáceres has begun using the mixed reality glasses, whose technology combines virtual reality with augmented reality, with the aim of developing, on the on[...]

30 Nov

Pablo Laguna New Elevated IEEE Fellow for his contributions to cardiac biomedical signal processing

Pablo Laguna, Scientific Director of NANBIOSIS Unit 27, has recently been appointed as a select member (IEEE fellow) of the Institute of Electrical and Electronics Engineers within the society of Medical Engineering and Biology -IEEE-EMBS-. The grade of Fellow recognizes unusual distinction in the profession and is conferred only by invitation of the IEEE Board of Directors upon a person with an extraordinary record of accomplishments in any of IEEE’s designated fields of interest, in this case, Dr. Laguna is recognized for his contributions to cardiac biomedical signal processing. The IEEE-EMBSis the world’s largest international society of biomedical engineers. The 11,000 members of[...]

29 Nov

Inkjet-Printed Sulfide-Selective Electrode

Gemma Gabriel, Scientific Coordinator of Unit 8 of NANBIOSIS is coauthor of the article  “Inkjet-Printed Sulfide-Selective Electrode” recently publish by ACS Publications in Analitical Chemistry.  Anal. Chem., 2017, 89 (22), pp 12231–12236   DOI: 10.1021/acs.analchem.7b03041     &nbs[...]

28 Nov

NANBIOSIS at CIBEREHD XI Annual Conferences

Jesús Izco, Coordinator of NANBIOSIS, has presented NANBIOSIS-ICTS at the XI annual Conference of  CIBEREHD, which takes place from 27 to 28 November 2017 at the Hotel Barceló Sants in Barcelona. Jesús Izco has explained the opportunities offered by the ICTS NANBIOSIS as a Platform for Research and Biomedical Innovation, giving examples of private-public collaboration in competitive calls  in which NANBIOSIS has participated and explaining the design of the new Nanomedicine Cascade Characterization Service, in which NANBIOSIS is working on. CIBEREHD (Center for biomedical research in liver and digestive diseases) is The CIBER’s thematic area of Liver and Digestive Diseases (CIBEREHD) has the purpose of promoting and[...]

20 Nov

Design of parenteral MNP-loaded PLGA nanoparticles by a low-energy emulsification approach as theragnostic platforms for intravenous or intratumoral administration

Encapsulation of magnetic nanoparticles (MNP) into PLGA nanoparticles has been achieved by nano-emulsion templating using for the first time both, a low-energy emulsification method as well as biocompatible components accepted for pharmaceuticals intended for human use. The incorporation of MNP by nano-emulsion templating method proposed in this work has been investigated in two different systems applying mild process conditions and is shown to be simple and versatile, providing stable MNP-loaded PLGA nanoparticles with tunable size and MNP concentration. MNP-loaded PLGA nanoparticles showed sizes below 200 nm by DLS and 50 nm by TEM, and mean MNP loading per PLGA nanoparticle of 1[...]

20 Nov

Intracellular trafficking of a dynein-based nanoparticle designed for gene delivery

Unit 1 of NANBIOSIS, Protein Production Platform (PPP) and the  Nanobiotechnology research group of CIBER-BBN in collaboration with the Universidade Estadual de Campinas and the Universidade de São Paulo have recently published, in the European Journal of Pharmaceutical Sciences, the results of the research devoted to the improvement of protein-only based nanoconjugates for gene therapy. The evaluated gene-therapy vehicle prototype  displayed a similar transfection efficiency to that of the commercial vector LipofectamineTM 2000. Article of reference: https://doi.org/10.1016/j.ejps.2017.11.002[...]

17 Nov

Unit 13 of NANBIOSIS participates in a new European project that will boost the Organ-on-Chip technology

The research group coordinating NANBIOSIS Unit 13 is the Spanish group of the European project ORCHID (Organ-On-Chip In Development). The scientists  of Engineering Research Institute (I3A) and CIBER-BBN, Luis Fernández and Iñaki Ochoa, will work on this project whose objective is to accelerate the social and economic impact of the technology known as Organ-on-Chip. This technology based on the use of microfluidic platforms is already facilitating the discovery of drugs, but it can go a step further with applications in personalized medicine and safety pharmacology and that, in addition, offers alternatives to conventional tests in animals. The mechanical properties and[...]

16 Nov

Posters presentation by NANBIOSIS Units in CIBER-BBN ANNUAL CONFERENCE 2017

Last 13 and 14 of November, CIBER-BBN  has celebrated its 11th Annual Conference in Hotel Santemar in Santander. In this conference there was a poster session with the participation of the following Units of NANBIOSIS. Special mention deserves Unit 1 with Neus Ferrer as Director and  Paolo Saccardo as Coordinator (in the picture): Posters: U1. Protein Production Platform (PPP): Engineering protein complexes as nano- or micro-structured vehicles or drugs for human and veterinary medicine. Ugutz Unzueta, Naroa Serna, Laura Sánchez-García, José Vicente Carratalá, Olivia Cano-Garrido, Mercedes Márquez, Paolo Saccardo, Rosa Mendoza, Raquel Díaz, Héctor, López-Laguna, Julieta Sánchez, Anna Obando, Amanda Muñoz, Andrés Cisneros, Eric Voltà, Aida Carreño, José[...]

10 Nov


CIBER-BBN will celebrate its 11th Annual Conference on November 13 and 14 in Santander. In these conference there will be a session dedicated to NANBIOSIS. Likewise, the annual meeting of the Scientific Technical Advisory Committee of NANBIOSIS will take place. As in previous occasions, the meeting will serve to know the activity of NANBIOSIS, the Singular Technical Scientific Infrastructure (ICTS) of the CIBER-BBN and the Minimally Invasive Surgery Center Jesus Usón for the production and characterization of biomaterials, nanomaterials and devices up to its preclinical validation. As a novelty, it will be presented at the conference, the new internal structure, generated by[...]

19 Oct

NANBIOSIS presented at the 12th annual event of the ETPN

During the days 17-19 of October Malaga has hosted the 12th annual event of European Platform of Technology in Nanomedicine (ETPN), a European meeting of 200 experts in research and innovation in nanomedicine. The meeting was organized by Bionand, the Spanish Platform of Nanomedicine (Nanomed Spain), the Institute of Nanoscience of Madrid (Imdea) and the Center for Biomedical Research Network in the area of ​​Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), partner of NANBIOSIS. During the event, the ETPN General Assembly took place as well as parallel meetings of the specialized working groups on different scientific and cross-cutting aspects related to nanomedicin[...]

16 Oct

Nanomedicine Summer School

The second Summer School in Nanomedicine coordinated by Simó Schwartz, Scientific Director of NANBIOSIS unit 20,  was held at Vall d’Hebron hospital on 28 and 29 September. Dr. Schwartz has been the president of the European Society for Nanomedicine (ESNAM), a European scientific society focused on the clinical application of nanomedicine. From this society tasks are carried out to promote the research and the use of nanomedicine in the health sector, as well as to facilitate the exchange of knowledge in this area at European level among all the actors involved, Academy, industry and entities regulators. CIBER-BBN, partner of NANBIOSIS,[...]

06 Oct

JUMISC, partner of NANBIOSIS, represents Spain in a European network of 22 countries

The Jesús Usón Minimally Invasive Surgery Centre (JUMISC), partner of NANBIOSIS toguether with CIBER-BBN,  leads a multidisciplinary European research network to improve present urinary stents and prevent their causes of failure. The idea of creating the network was born from a research, started in 1999 by Doctor Soria, Researcher-Coordinator of the Endoscopic Surgery Area at the JUMISC and the promoter of the mentioned network, representing Spain. His proposal has been supported by the European and Spanish Urology Association, and funded by the Horizon 2020 Program-Cost Actions (European Cooperation in Science and Technology) The focus of this Action is to creat[...]

06 Oct

New Zealand White rabbit as a model for preclinical studies addressing tissue repair at the level of the abdominal wall.

Juan Manuel Bellón and Gemma Pascual, Scientific Director and Coordinator of Unit 17 of NANBIOSIS, have recently published an article in the prestigious journal Tissue Eng Part C Methods. Once a prosthetic material is implanted, an inflammatory reaction is induced in an attempt to remove it or isolate it from the host tissue. After this initial response, a cellular response takes place that gives rise to the start of the process of integration of the biomaterial within the host tissue. Immunohistochemical studies can provide information on the events that regulate this process, and are useful to analyze the progression of t[...]

29 Sep

Best Abstract award at the European Society for Surgical Research meeting

Verónica Gómez-Gil, collaborator in Unit 17 of NANBIOSIS and the GITBIT-UAH group (CIBER-BBN), has been the first prizewinner in the Best Abstract Competition  at the symposium “New horizons in prevention and treatment of adhesions” organized by the Dutch Adhesion Group (DAG) at the 52nd meeting of the European Society for Surgical Reseach (ESSR). The ESSR 2017 meeting was held in Amsterdam from 14th till 17th June. The title of the abstract, presented as a quick-shot presentation and a full oral during the congress, was: An experimental adhesiogenic model to evaluate histological events over time in the omentum during adhesion formation.[...]

29 Sep

CIBER-BBN, partner of NANBIOSIS, leads the European initiative Nano4p, reference in Nanomedicine

CIBER-BBN along with other leading partners from various European countries, are setting up the “Precision Nanomedicine for People (Nano4P)” Flagship Initiative (www.Nano4P.eu). Nano4P aims to develop material science and nanotechnology-based highly precise tools for the detection and tailored treatments of diseases, based on the unique characteristics of each person and taking advantage of stratification and molecular-level information. In this way, the paradigm shift that is already becoming visible in the healthcare system, will definitively enable to move from traditional treatment of diseases by existing drugs/tools, towards a predictive, preventive, precise and participatory (4P) medicine. FET-Flagship Initiatives tackle grand science and[...]

27 Sep

NANBIOSIS at the EATRIS Conference Translational Medicine 2017

NANBIOSIS  has actively participated in the third bi-annual conference organised by EATRIS, (the European infrastructure for translational medicine) in Prague on 24-26 of September Translational Medicine 2017: Enhancing predictivity in medicines development . The event gathered a wide range of stakeholders (industry, academia, policymakers) and focussed on bringing together the latest approaches to increase chances of success in drug development, from novel in vitro systems to new biomarkers or clinical trial methodology for patient selection and stratification. Jesús Izco, Coordinator of NANBIOSIS, presented NANBIOSIS initiatives of joint collaboration, which were well received and will be coordinated and developed during t[...]

18 Sep

FORUM “Intelligent Biomaterials and Biomedical Devices for Drug Delivery and Regenerative Medicine”

NANBIOSIS organizes a forum for researchers and companies. Dates (probably February 2018) and location (probably Madrid) will be announced soon. The theme of the Forum is INTELLIGENT BIOMATERIALS / FUNCTIONALIZATION AND BIOMEDICAL DEVICES FOR APPLICATIONS IN REGENERATIVE MEDICINE AND DRUG DELIVERY. The forum is presented through 2 sessions: • First session: Short interventions of the latest advances and developments in the lines of research developed by the groups and platforms of Nanbiosis and description of the needs and demands of industry in that area. The companies and groups that request it will be able to have about 10 ‘to present[...]

06 Sep


A new extraordinary deadline for admissions to the II MASTER ON ENDOSCOPY AND MINIMALLY INVASIVE SURGERY IN SMALL ANIMALS has been set up, from 1st to 14th September. It is organised in collaboration with the Extremadura University ant takes place in Jesús Usón Minimally Invasive Surgery Centre as affiliated entity, offering 60 ECTS-credits.Necessary requirements include having a Veterinary studies degree and a B1 English Certificate. The Master will be held during the academic calendar 2017-2018, according to the established program, that will promote the interaction with the students via an on-line training platform, the direct contact with professors and experts,[...]

05 Sep

Gold nanoparticles can activate drugs inside tumors

Jesus Santamaría, Scientific Director of Unit 9 of NANBIOSIS has participated in a study that shows the ability of gold nanoparticles to generate in situ potent anticancer drugs from inert molecules thanks to a mechanism of elimination of terminal chemical groups that nanometric gold is able to catalyze. Gold is ideal for this catalytic role due to its high biocompatibility. These results, published in the journal Angewandte Chemie, offer new hope in the fight against cancer and have been obtained thanks to the collaboration of scientists of Unit 9 of NANBIOSIS and, Víctor Sebastián, Silvia Irusta and Jesús Santamaría, wit[...]

27 Jul

Nanomedicine applied to Dermatology by Almirall, Leitat Technology Center & NANOMOL (NANBIOSIS U6)

NANOMOL (ICMAB-CSIC), a research group member of ICTS “NANBIOSIS”, more specifically of the Biomaterial Processing and Nanostructuring Unit (U6), announced today the launch of Nano4Derm, a research project in collaboration with Almirall, S.A and Leitat Technology Center, focused in nanomedicine applied to treat dermatological diseases. Within the framework of this research project, new innovative formulations containing nanoencapsulated active ingredients will be developed for the topical treatment of inflammatory skin conditions, such as Acne and Psoriasis. Nano4Derm involves the development and physico-chemical and biological characterisation of nanocapsules containing active ingredients, and the generation of scalable formulation prototypes for manufacturing nanoformulations suitab[...]

13 Jul

3D bioprinting applied to cancer diagnostics

Mateu Pla Roca, Scientific Coordinator of Unit 7 of NANBIOSIS /IBEC Core Facilities has won CaixaImpulse funding for his project “3D bioprinted array tissue-like cores: tissue-like controls for cancer diagnostics” (3DBIOcores), which will be carried out in collaboration with Antoni Martinez, head of the histopathology service at Hospital Clinic. CaixaImpulse programme aims to promote technology transfer in science. The project 3DBIOcores will take advantage of 3D bioprinting to create quality control samples that assure and improve cancer diagnostics. Usually, diagnosis is done by histopathology – the microscopic examination of tissues – and then the biomarkers that are found are quantified. However,[...]

13 Jul

Conflicting evidence for ferroelectricity – New publication in NATURE by scientists of NANBIOSIS

Researchers from Unit 6 of NANBIOSIS, -ICMAB (CSIC)/CIBER-BBN-, in collaboration with others from the Universities of Liège, Mons, Grenoble-Alpes, Parma, Augusburg, Girona and CNR-IOA (SISSA) have published in the journal Nature (G. D’Avino et al., Nature, 547, E9-E10, 2017) an article questioning the presence of ferroelectricity at room temperature in organic charge transfer crystals, generated by supramolecular techniques, previously published in the same journal (Tayi et al, Nature, 488, 485-489, 2012), by a team led by Profs. J. Fraser Stoddart (Nobel Prize for Chemistry 2016) and Samuel I. Stupp of the University of Northwestern. For more information: D’Avino et al,[...]

06 Jul

XI International Workshop on Sensors and Molecular Recognition: System for detection of senescent cells in vivo

The XI International Workshop on Sensors and Molecular Recognition will take place on 6 and 7 July 2017 at the Polytechnic University of Valencia. Scientists of the unit 26 of NANBIOSIS will present the results of the research carried on together with researchers from the Universitat Politècnica de València, CNIO, CIBER-BBN and the University of Cambridge: an innovative system that allows the detection of senescent cells in vivo and without damaging the tissue. The main objective of cellular senescence is to prevent the proliferation of damaged cells and, at the same time, to trigger tissue repair. However, when the damag[...]

06 Jul

NANBIOSIS: collaborative research opportunities for groups of CIBER consortia

Last week, Jesús Izco, coordinator of NANBIOSIS, presented to CIBER groups the capabilities of NANBIOSIS and the opportunities for collaboration with the ICTS. From these meetings emerged diverse expressions of interest on the part of the attending researchers. On June 30, Jesús Izco was invited to present NANBIOSIS in the Annual Scientific Conference of CIBERES. He explained several investigations that are currently being developed in NANBIOSIS and can be applied in the diagnosis and therapy of respiratory diseases, such as the development of physical devices and tests that allow the detection of biomarkers, new protein carriers in the format of[...]

27 Jun

Update of the Map of Unique Scientific and Technical Infrastructures (ICTS) 2017-2020

The updating of the Spanish ICTS Map aims to consolidate this map as a tool for long-term planning and development of this type of infrastructure, updating it according to established criteria, with emphasis on quality and scientific-technical and economic sustainability, prioritizing the continuity Of the installations in operation and those that have viable financing scenarios, implementing it jointly with the Autonomous Communities. This tool also makes it possible to optimally plan the application of national, regional and European funding, in particular FEDER funds from the programming period 2014-2020, aiming to achieve a stable medium-term funding framework to guarantee the achievement of[...]

22 Jun

New methodology for cancer screening paves the way for more targeted treatment options

Laura Lechuga, Scientific Director of Unit 4 of NANBIOSIS, is co-author of a new paper published in Scientific Reports. According to Cesar Huertas, co-author of the article, the Gene expression is the process by which information from a gene is converted into a functional product, such as a protein. It is controlled by a complex regulatory network wherein diverse cellular mechanisms enable the cell to respond to its ever-changing environment. One such mechanism is alternative splicing (AS) of mRNA precursors, a particularly flexible regulatory control point where diverse protein isoforms of differing, even opposing, functions are generated. However, these regulation[...]

22 Jun

Two researchers from NANBIOSIS Unit 27 obtain new European projects “Marie Curie”

The European Union has selected the projects sponsored by two researchers from Unit 27 of NANBIOSIS: Esther Pueyo, with “PIC”, to customize the diagnosis and cardiovascular treatment and Pablo Laguna, with “MY-ATRIA”, to improve the early detection of arrhythmias Cardiac. Both projects include massive calculations that will be executed through  unit 27 of NANBIOSIS, High Performance Computing. “MY-ATRIA” / Mutlidisciplinary and training network for Atrial fibrillation monitoring, treatment and progression “, by Pablo Laguna, Professor of Signal Theory and Communication and researcher of the group BSICoS of I3A and CIBER-BBN and Scientific Director of Unit 27 of NANBIOSIS, will affect t[...]

21 Jun

NANOMEDICINE AND FUTURE, explained by Simó Schwartz, Director of U20 of NANBIOSIS.

NANBIOSIS-U20 Scientific Director, Simó Schwartz, speaks about Nanomedicine in an interview publish in http://www.quimicaysociedad.org.  NANBIOSIS is an Singular Scientific Technological Infrastructure (ICTS) that provides a complete service for the production and characterization of nanomaterials, biomaterials and systems in biomedicine, including the design and production of biomaterials and nanomaterials and their nanoconjugates, and the characterization of these bio-/nanomaterials, tissues and medicals devices from a physic-chemical, functional, toxicological and biological (including preclinical validation) point of view, focused also on biomedical applications such as: IVDs, biosensors, regenerative medicine, drug delivery, therapeutic agents or MRI contrast agents and medical devices. Question: First of all,[...]

07 Jun

Nanoparticles capable of bi-directional communication

The results of a research co-led by Ramón Martínez-Máñez, Scientific Director of Unit 26 of NANBIOSIS and CIBER-BBN have been published by Nature Communication last May 30th, showing how to prepare a nanoparticles chemical communication system using lactose. So far, his group had managed to establish communication between three nanoparticles but only in a unidirectional way. “We have managed to get a nanoparticle to send a chemical messenger to the second nanoparticle, who understands the message and sends another chemical messenger back to the first one. Upon receiving it, it performs an action, in this case releasing a dye,” explains[...]

02 Jun

NANBIOSIS at the VI Conference of Young Researchers

On June 2, the VI Conference of Young Researchers organized by the I3A at the University of Zaragoza was held, aimed at doctoral students who have as director or co-director an I3A member. The inaugural lecture was given by José Antonio Sanz Herrera (Professor Contractor Doctor at the University of Seville and who held his doctorate at I3A) who has talked about Multidisciplinary Research as the basis of the young professor in engineering. After the inaugural conference a first block was opened with four oral presentations, giving way to the poster session and coffee. A second and final block wit[...]

29 May

DHA and l-carnitine loaded chitosan hydrogels as delivery systems for topical applications

The journal JCR Colloids and Surfaces A: Physicochemical and Engineering Aspects, has recently publish and interested article which show the results of the research lead by Jordi Esquena, Coordinator of Unit 12 of NANBIOSIS,. The formation of biocompatible hydrogels of chitosan crosslinked with genipine deposited on textile substrates has been studied and the incorporation and release of active ingredients for cosmetic applications has been investigated. The active principles studied have been dihydroxyacetone (DHA), which produces a sunless tanning effect; And carnitine, used as anti-cellulite agent. The results have shown that crosslinking with chitosan allows controlling the release rate of the active ingredients,[...]

29 May

Nanomedicine versus free drug: greater efficiency and less toxicity

The EU-NCL network will finance a project of nanomedicine for prostate cancer cordinated by Simó Schwartz and Ibane Abasolo, NANBIOSIS-U20 Director and Coordinator. The European Nanomedicine Characterisation Laboratory (EU-NCL) has selected a project from VHIR intended to develop a therapeutic nanoconjugate that improves the treatment of prostate cancer. Among all proposals presented to EU-NCL, only this one in Spain is part of a small group chosen to carry out the necessary tests to move the product into clinical practice, which makes Vall d’Hebron Campus a leading nanomedicine hospital with capacity to generate and validate therapeutic nanoconjugates and nanomedicines. The main difficulty in this[...]

24 May

Elastic and adhesion properties of adsorbed hydrophobically modified inulin films on latex particles using Atomic Force Microscopy (AFM)

In a study published in the journal Colloids and Surfaces A: Physicochemical and Engineering Aspects, by Jordi Esquena, Coordinator of Unit 12 of NANBIOSIS, among others, it has been shown that the latex particles dispersed with graft-type polymeric surfactants have excellent colloidal stability, which is attributed to the repulsion forces between the particles, which arise from the presence of adsorbed surfactant molecules. These forces of repulsion have been studied by means of Atomic Force Microscopy (AFM), between an AFM tip and a latex particle, with the presence of surfactant adsorbed on both. It has been observed that this repulsion is maintained even[...]

23 May

Electronic tongues for detecting prostate and bladder cancer

Researchers of the Applied Molecular Chemistry Group, coordinator of Unit 26 of NANBIOSIS, have participated in the development of a new low-cost system for non-invasive diagnosis of prostate and bladder cancer. It consists of a device of electronic tongues ​​based on metal electrodes, which makes it possible to quickly and easily detect this pathology from a urine sample. The researchers evaluated the efficacy of this system from the analysis of urine samples from patients before and after surgery. In addition, samples were collected from patients with benign prostatic hyperplasia, integrated into the non-cancer group for the study of prostate cancer.[...]

19 May

NANBIOSIS at CIBERDEM Annual meeting

Jesús Izco, Coordinator of NANBIOSIS, has presented NANBIOSIS-ICTS at the annual meeting of all CIBERDEM research groups, which takes place from 17 to 19 May 2017 at the Campus Hotel, on the Campus of the Universitat Autònoma de Barcelona, in Cerdanyola del Vallès. Jesús Izco has explained the opportunities offered by the ICTS NANBIOSIS as a Platform for Research and Biomedical Innovation, giving examples of private-public collaboration in competitive calls (INNPACTOP, Challenges and H2020) in which NANBIOSIS has participated and explained the design of the new Nanomedicine Cascade Characterization Service, in which NANBIOSIS is working on. CIBERDEM (Diabetes and Associated Metabolic Diseases)[...]

18 May

Platform2nano research by Víctor Sebastián, (Unit 9 of NANBIOSIS) awarded Marie Skłodowska-Curie

The Platform2nano research project (2012-2016) has just been awarded a second prize in the “Contribution for a better society” category, at the “Mobility Takes Research Further” conference organized by Marie Skłodowska-Curie actions (MSCA 2017) in the framework of the Presidency of Malta of the Council of the European Union. More than 195 researchers from 30 nationalities who have developed their scientific work through the prestigious Marie Skłodowska-Curie Scholarships were presented to these awards. The project “Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications” in which participate the researchers Manuel Arruebo, Laura Usón, Isabel Ortiz[...]

16 May

New gelatine devices that mimic the body’s activity in bone regeneration

The NanoBioCel Group, Coordinator of Unit 10 of NANBIOSIS has led the development of new scaffolds (such as burns, trauma or tumour extractions), to regenerate critical bone defects that, in addition to physical support, offers the opportunity to release growth factors temporarily replacing the bone matrix and aiding the regeneration of bone tissue. In order to make the material biodegradable, and reduce the risk of rejection, “we use a collagen derivative, a gelatine that is produced by processing collagen, since it has been found to be less cytotoxic than collagen itself, but maintains the properties we were looking for”, explains[...]

16 May

Unit 6 of NANBIOSIS-ICTS Biomaterials processing and Nanostructuring at ICMAB-CSIC received the visit of high school students

A group of 22 students from the high school La Serra (Mollerusa) visited the Biomaterials and Nanostructuring Unit of NANBIOSIS,  at the Institute of Material Science of Barcelona of CSIC. The visit was an activity within the Nanoscience and Nanotechnology festival 10alamenos9  in which ICMAB participates. The students were guided through the labs by Amable Bernabé, technical responsible of U6, who explained them about nanotechnology, NANBIOSIS-ICTS research infrastructure and the different techniques available at “Biomaterials processing and Nanostructuring Unit”.[...]

15 May

NMR signal enhancement of >50 000 times in fast dissolution dynamic nuclear polarization

Jaume Veciana, Scientific Director of NANBIOSIS-ICTS has participated  in the research results published in the journal Chemical Communication, wich reports the synthesis and the study of a novel mixed biradical with BDPA and TEMPO radical units that are covalently bound by an ester group (BDPAesterTEMPO) as a polarizing agent for fast dissolution DNP. The biradical exhibits an extremely high DNP NMR enhancement of >50000 times, which constitutes one of the largest signal enhancements observed so far, to the best of our knowledge. Some of the researchs were made taking advantage of the characterization facilities provided by ICTS NANBIOSIS. For more information: L. F.[...]

12 May

Nanotechnology and biomedical applications. Gene therapy

Yesterday, at the University of Zaragoza, Prof. Nuria Vilaboa (CIBER-BBN– Hospital Universitario de La Paz) gave a talk  on “Nanotechnology and biomedical applications. Gene therapy“. The event was organized by Manuel Arruebo II Institute of Nanoscience of Aragon), researcher of the coordinating group of Unit 9 of NANBIOSIS. In recent years, a multitude of materials of nanometric size have been explored, which because of their small size have properties that give them a great attraction for a wide range of biomedical applications. Prof. Vilaboa reviewed gene therapy technology, where materials at  nanoscale offer interesting alternatives.[...]

11 May

NANOMOL group, coorditator of Unit 6 of NANBIOSIS has authored 26% of the scientific articles of ICMAB in NATURE

The Nature Index takes into account the published scientific articles from 1 February 2016 to 31 January 2017.  This index is elaborated annually based on the affiliations of the authors of scientific articles published in a selection of 68 high-quality journals (http://www.natureindex.com/faq#journals) CSIC appears as the first Spanish research centre in this ranking and occupies position number 38 in the global ranking of 500 research centres worldwide, while ICMAB occupies the first position within the CSIC centre, taking into account the corrected index WFC that shares the work between the different co-authoring institutions and corrects for the overrepresentation of som[...]

08 May

JUMISC awarded with the Prize to the Best Research Practice

Last Friday, May 5, JUMISC was awarded in the 1st edition of Extremadura Health Prices, event organised by Sanitaria 2000, text-editor of the Redacción Médica, the most famous and specialised newspaper in its sector. The contribution of the Extremadura Health Service and the regional health sector were awarded between the 56 nominations included in 14 categories. JUMISC obtained the award of “Best Research Practice”. The event was held in the convent of San Juan de Dios, in Olivenza-Badajoz, and gathered the JUMISC’s Scientific Director, Mr. Sánchez Margallo (on behalf of the institution),  together with other authorities and health managers. A[...]

08 May

New sensor for quick and easy detection of ecstasy

Spanish, Danes and Austrian researchers, including the group led by Ramón Martínez Mánez, coordinator of Unit 26 of NANBIOSIS, have developed a new sensor to detect ecstasy in a simple, reliable, fast and selective way. Until now, this drug is detected by techniques such as capillary electrophoresis, spectroscopy or chromatography that require the use of expensive technical equipment and qualified personnel. The new method offers the advantages of easy use, low cost and high reliability according to Beatriz Lozano, a researcher at the Interuniversity Institute for Research on Molecular Recognition and Technological Development at the Universitat Politècnica de València and[...]

05 May


The ESNAM / ISNM Summer School is co-organized by ESNAM and CIBER-BBN (led by Simó Schwartz, president of ESNAN and transfer manager of CIBER-BBN as well as Scientific Director of Unit 20 of NANBIOSIS). The summer school is aimed at any student or professional interested in nanomedicine. It will count on the presence of speakers of recognized prestige in the area, among which are the Scientific Directors and Coordinators of several of the units of NANBIOSIS. The ESNAM / ISNM Summer School will be held on 28-29 September 2017 at the Hospital Vall d’Hebron, Barcelona The registration deadline with accommodation included ends on[...]

04 May

Laura Lechuga in the fight against cancer

Dr. Laura Lechuga, Scientific Director of Unit 4 of NANBIOSIS is highlighted in Cinco Días. Elpais Economía  for its fight against cancer and, in particular, for the device developed with its team to detect the disease in matter of minutes “Have you ever wondered why glucose meters are so smart that they just measure sugar? The answer is that they carry specific proteins that only interact with sugar, “explains the doctor.  The same idea lies in the device designed by Laura Lechuga and her research group “With a minimum sample of the patient, it is possible to detect the presenc[...]

23 Apr

NANBIOSIS Scientific Director Dr. Jaume Veciana received a Mention of Honor for his dedication to NANBIOSIS

On April 22, Dr. Jaume Veciana received a Mention of Honor from the current President of Extremadura, Guillermo Fernández Vara, during the celebration of the X Anniversary of the Center for Minimally Invasive Surgery “Jesus Usón” for his commitment, effort and dedication in the creation of the Singular Scientific Technological Infrastructures (ICTS) NANBIOSIS, in collaboration with the Center for Biomedical Research Center in Bioingeneering, Biomaterials and Nanomedicine (CIBER-BBN). Further information:[...]

20 Apr

J. Santamaría, U9 NANBIOSIS gets 2.5M € to develop a revolutionary cancer treatment

Jesús Santamaría, Scientific Director of Unit 9 of NANBIOSIS, has obtained, for the second time in six years, an ERC Advanced Grant, one of the most prestigious and extremely competitive European research grants, restricted to senior researchers with a research trajectory of high quality for more than ten years. The CADENCE (Catalytic Dual-Function Devices Against Cancer) project will be financed by the EU with 2.5M € to work for five years with a powerful team: four own researchers and seven others to be selected from candidates from all over the world. With this project the researchers propose a revolutionary cancer[...]

20 Apr

10th Anniversary of the New Minimally Invasive Surgery Centre (JUMISC)

Next Friday, 21st April, we celebrate the 10th Anniversary of the new JUMISC, betting on training and on research and development activities.  In its ten years of background we emphasize the following figures: 500 trained physicians, 160 training activities per year More than 100 R&D projects with 7.930.800 € funding 17 patents, The creation of a spin-off, The development of 25 apps, More than 623 scientific collaborators, 500 visits received from more than 500 institutions. 10 years full of training courses and European R&D projects. We are so proud for  the promotion and creation of the  Clúster Sociosanitario of Extremadura[...]

18 Apr

New treatments for degenerative diseases of the retina

The final meeting of the TERET project took place last March, an initiative within the RETOS public-private collaboration initiative of the Ministry of Economy, Industry and Competitiveness funded with almost € 1 million. The project has been carried out over the past three years to develop new treatments for degenerative diseases of the retina, focusing specifically on age-related macular degeneration (AMD), diabetic retinopathy ( RD) and retinitis pigmentosa. Unit 10 of ICTS NANBIOSIS has participated in carrying out the pharmaceutical formulation of the active principles, including the synthesis, chemical physical characterization and stability of the formulations over time, evaluation of[...]

17 Apr

Unit 2 Nanbiosis have signed an agreement with a Belgian Enterprise.

U2 unit of Nanbiosis (Custom antibody service) has recently signed a 3-year contract with UNISENSOR S.A. (Liege, Belgium) for producing on a high scale a collection of immunoreagents used in their diagnostic kits. UNISENSOR S.A. is a SME biotech company that develops on site diagnostic systems for food safety. Unit 2 of NANBIOSIS, coordinated by Nb4D-CSIC holds a research collaboration for more than 7 years developing new bioproducts and transferring knowledge to UNISENSOR S.A. As result of the collaboration several diagnostic kits are nowadays in the market, consequently this contract has been signed with the aim to supply UNISENSOR S.A. with immunoreagents for their[...]

06 Apr

Materials for Biomedical Applications Scientific School (BIOMAT-2017)

Registration is now open for the Scientific School on Materials for Biomedical Applications (BIOMAT-2017) that will take place on 19th-22nd of June 2017 in the UAB Campus (Barcelona). This school is organized by ICMAB-CSIC and it is included in the Severo Ochoa activities of the Institute. The school is addressed to last year undergraduate, master and PhD students, who are interested in the development of materials for biomedical applications. The aim of the school is to present the design, development and application of new materials for a wide range of biomedical applications. The school includes lectures from international and loca[...]

06 Apr

Laboratory-scale prototype for the treatment of cutaneous tumours

Ramon Martínez Máñez, Scientific Director of Unit 26 of NANBIOSIS, has participated in the development, on a laboratory scale, of a low cost device for treatments based on the application of optical hyperthermia by laser. Among the applications of this technique are the therapies against cutaneous cancer and its objective is to get the death of the tumour cells by overheating. Overheating is achieved by the irradiation of synthesized metal nanoparticles. The prototype developed consists of an infrared laser with a power of up to 500mW able to provide a power density of up to 4W / cm2, a sensor[...]

30 Mar

Methods for the In Vitro Characterization of Nanomedicines —Biological Component Interaction

An interesting article has been recently published, in the journal Personalized Medicine In the context of a public-private collaboration between Cristina Fornagera of Sagetis-Biotech and Conxita Solans, Scientific Director of Unit 12 of NANBIOSIS This review summarizes the main techniques used to assess the interaction of nanomedicines with biological systems, highlighting their advantages and disadvantages. The translation of knowledge from novel designed nanosystems at a research laboratory scale to real human therapies is usually a limiting or even a final point due to the lack of systematic studies regarding two aspects: nanoparticle interaction with biological components and nanoparticle cytotoxicity. For[...]

30 Mar

A new versatile methodology to produce polymeric nanoparticles loaded with gold nanoparticles

Conxita Solans, Scientific Director of Unit 12 of NANBIOSIS together with researchers of her group, Colloidal and Interfacial Chemistry of CIBER-BBN and IQAC-CSIC and the Department of Pharmacy and Pharmaceutical Technology, University of BarcelonaIn have published the research paper “Versatile Methodology to Encapsulate Gold Nanoparticles in PLGA Nanoparticles Obtained by Nano-Emulsion Templating” in the journal Pharmaceutical Research. The scientists have shown that a novel and very versatile methodology has been developed for the production of polymeric nanoparticles loaded with gold nanoparticles. In this work, gold-nanoparticles (AuNP) have been encapsulated in polymeric nanoparticles using a novel and versatile methodology based on nano-emulsion templating, whic[...]

28 Mar

New bioadhesive with 3D printing technique to improve pterygium surgery

Dr. José Luis Pedraz, head of Nanobiocel group and Scientific Director of Unit 10 of NANBIOSIS, participates in the public-private collaboration BIOTAPE project that will develop a new bioadhesive for its application in pterygium surgery to improve the currently used surgical techniques in the treatment of this eye disease that affects the conjunctiva and cornea. The main cause of pterygium is the lack of lubrication of the eye by the tear film. This lack of lubrication may be due to various external factors such as excessive exposure to sunlight, harsh environmental conditions or even allergens, which causes dryness and subsequent[...]

24 Mar


On March 15, Jesús Izco presented NANBIOSIS at the conference organized by CIBERSAM on Therapeutic Innovation. The event, that took place in the Hospital del Mar of ​​Barcelona, ​​with an audience of about 80 people, was attended by Jesús Izco, coordinator of NANBIOSIS as a guest to talk about Innovation Platforms. Jesús Izco explained the opportunities offered by the ICTS NANBIOSIS as a Platform for Research and Biomedical Innovation, giving examples of private-public collaboration in competitive calls (INNPACTOP, Challenges and H2020) in which NANBIOSIS has participated and explained the design of the new Nanomedicine Cascade Characterization Service, in which NANBIOSIS is working[...]

22 Mar

Three Scientifics of NANBIOSIS in University of Zaragoza ERC 10 years celebration event

2017 is the year of the X Anniversary of the European Research Council (ERC), created to finance research projects of excellence at the frontier of knowledge of any scientific discipline. The structure of the ERC consists of an autonomous scientific council made up of 22 distinguished scientists supported by an executive agency that is responsible for implementing the program, organizing the evaluation and managing the aid. The University of Zaragoza, hosting three units of NANBIOSIS, joined the celebrations with an event that took place on March 15. Among the assistants, three Scientists of NANBIOSIS recognized with ERC: Jesús Santamaría, Scientific[...]

21 Mar

NANBIOSIS by Pablo Laguna in CIBER-BBN Bulletin
NANBIOSIS by Pablo Laguna in CIBER-BBN Bulletin

Pablo Laguna, Scientific Director of Unit 27 of NANBIOSIS considers the added value offered by the ICTS NANBIOSIS in an interview at February 2017 CIBER-BBN Bulletin. “The relevance of the ICTS NANBIOSIS is to make available to the entire scientific community of unique infrastructures that are shared and exploited in the most optimal way avoiding redundancies.” – Explains Pablo Laguna – “Having an incentive interaction mechanism, within the same centre, it has been addressed and are tackling challenges and projects with much greater depth, both in the excellence of the research, and in its possibilities of translation to the clinic[...]

10 Mar

NANBIOSIS at the X Conference of Technological Platforms of Biomedical Research

On March 8, 2017, the 10th Annual Conference of Technological Platforms of Biomedical Research took place in Madrid on the theme Innovative Medicines, Nanomedicine, Health-care Technologies and Biotechnology Markets. Jesús Izco, Coordinator of NANBIOSIS, participated in the round table on New Public-Private Cooperation networks, together with the Scientific Directors of the recently created CIBER Areas of Fragility and Aging, Oncology and Cardiovascular Diseases, as well with as the coordinators of the Networks of Clinical Essays and the network of Discovery of Drugs. The coordinator of NANBIOSIS explained the opportunities that the ICTS offers as a Network of Excellence for Research and Biomedica[...]

02 Mar

U 26 NANBIOSIS - New implants for the treatment of infections and bone tumours
New implants for the treatment of infections and bone tumours

Researchers of Unit 26 of NANBIOSIS participate in the design and evaluation of the cellular level of a new hybrid material for the creation of intelligent-scaffolds implants that open the door to a more efficient treatment of infections and bone tumors. The main novelty is the incorporation of a mesoporous matrix of silicon, calcium and phosphorus oxides, with molecular gates that would allow the controlled release of substances stored inside the pores, such as antitumor drugs or antibiotics. A molecular gate is a mechanism whose opening depends on certain external stimuli, in this particular case the drugs would only b[...]

02 Mar

U1 NANBIOSIS - Public-Private collaboration to Investigate New Inhibitors Against Pain
Public-Private collaboration to Investigate New Inhibitors Against Pain

Unit 1 of NANBIOSIS, together with Synchroton Alba and the pharmaceutical ESTEVE jointly investigate the mechanisms of new inhibitors against pain ESTEVE, a chemical – pharmaceutical group leader in Spain and with an important international presence, has developed new inhibitors against pain. Collaboration with scientific expertise of the Protein Production Platform and the ALBA Synchrotron will allow studyingthe interaction of these inhibitors with its potential target. The results of the research may help to the better understanding of the effects of the inhibitors and will provide key information to improve their properties. The  Protein Production Platform (Unit 1 of NANBIOSIS) is in[...]

28 Feb

3D printing biocompatible hydrogels

  Researchers of Unit 5 of NANBIOSIS, in collaboration with colleagues from the University of Montpellier, have laid the groundwork for faster advances in 3D printing for regenerative medicine by creating a system of ink and matrices that offers a solid basis for tissue regeneration. Due to their high water content, hydrogels are highly attractive biomaterials for 3D printing as efficient ‘surrogates’ for the extracellular matrix, onto which cells can be cultured. However, while they are relatively easy to produce using a method called extrusion printing, their stability and structural integrity can weaken when they’re in contact with biological fluids[...]

15 Feb

Unit 25 of NANBIOSIS and the research field of Protein Kinase CK2. 

Ana Paula Candiota and Carles Arús, Scientific Coordinator and Scientific Director of Unit 25 of NANBIOSIS, jointly with other GABRMN members, have recently published an interesting article in the journal Pharmaceuticals, (Special Issue An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2). This article  is also co-authored by scientifics of a research group with renowned prestige in CK2 research field, the Protein Phosphorylation group, del Dipartimento di scienze biomediche (Università degli Studi di Padova). This publication describes a study with the preclinical glioblastoma (GB) model and its treatment, centered in exploring the potential of[...]

14 Feb

Bioengineering is being strengthened in Spain

Estefanía Peña, Scientific Coordinator of Unit 13 of NANBIOSIS explains her resarch in the program “En route with science” of Aragon Television. Bioengineering consists in the application of the principles of engineering to the field of medicine. In the opinion of Estefanía, coordinator of the Division of Biomedical Engineering and deputy director of I3A (Institute of Research in Engineering of Aragon) Bioingineering is being strengthened in Spain. “Our research develops mathematical models and computational reproduction, especially of cardiovascular diseases and the therapies to solve them. Fundamentally we work on atherosclerosis, which is the appearance and development of atheroma plaque (a cluster of[...]

13 Feb

Titania-coated gold nanorods with expanded photocatalytic response

New communication in the Journal Nanoscale, from the Royal Society of Chemistry by NFP Group, coordinator of Unit 9 of NANBIOSIS. Jesús Santamaría, Scientific Director of Unit 9 of NANBIOSIS together with other authors of the Nanostructured Films and Particles (NFP) Group, coordinator of Unit 9 of NANBIOSIS, has published on February 7, 2017, a Communication in the Journal Nanoscale, from the Royal Society of Chemistry. The syntheses of materials during the research have been performed by the Platform of Production of Biomaterials and Nanoparticles of the NANBIOSIS ICTS, more specifically by the Nanoparticle Synthesis Unit, as stated in the publication. Gold[...]

09 Feb

MATERPLAT Steering Committee
Jesús Izco, Coordinator of NANBIOSIS, leading the Health Innovation Group at the MATERPLAT Steering Committee Meeting

MATERPLAT, the Spanish Technological Platform of Advanced Materials and Nanomaterials, emerged in 2008 as framework for meetings and collaborations between the different agents of the National Enterprise, Science and Technology System interested in promoting the research, development and application of advanced materials and nanomaterials. On February 3, 2017 the leaders of the MATERPLAT Innovation Groups met to define the lines of action of the working groups during the year 2017. These groups are transportation, health, energy, raw materials, and cities Intelligent. They were present, following the order of the photograph: Back row, from left to right: Luis Guaita (KERABEN), José[...]

09 Feb

bioprinted human cells
3DBio-impression systems and bio-ink for the regeneration of cartilage and bone

The Nanobiocel Group, coordinator of Unit 10 of NANBIOSIS participate in a public-private collaborative project to reach clinical application in the regeneration of osteochondral lesions, which mainly affect the knee and ankle joints. The new project is funded by the Challenges-Collaboration program of the Ministry of Economy, Industry and Competitiveness. It has a budget of 691,000 euros for 3 years and the participation of two Spanish companies (Bioibérica and REGEMAT3D), the Higher Council for Scientific Research (CSIC), the University of Granada, the Center for Biomedical Research in Network Bioengineering, Biomaterials and Nanomedicine (CIBER -BBN) and its ICTS NANBIOSIS. The companies[...]

06 Feb

Equations that can save thousands of lives
Equations that can save thousands of lives

Esther Pueyo, from the research group BSICoS, coordinator of Unit 27 of NANBIOSIS, explains for the program “En route with science” of Aragon Television, her research on arrhythmias: irregularities in the functioning of the heart. Arrhythmias are the cause of 25,000 deaths per year and half of hospital admissions in Spain. First of all they study experimentally (extracting tissues from the heart of animals and humans) how the electrical activity of the said tissues is. Then, the information collected is introduced in mathematical models to understand the heart and to make predictions of what can happen in the future and[...]

06 Feb

A multiplexing nanophotonic biosensor for cancer diagnosis
A multiplexing nanophotonic biosensor for cancer diagnosis

The group Biosensors and bio-analytic applications, led by Laura Lechuga,​ coordinator of Unit 4 of NANBIOSIS, has developed a methodology through a nano-photonic sensor (known as bimodal waveguide interferometer) capable of quantifying, directly and mark-free, the different messenger RNA isoforms generated by alternative splicing. The expertise in biodeposition and biodetection systems of Lechuga’s group has permitted a thorough analytical study and optimization of the methodology, achieving not only total selectivity, but also excellent levels of sensitivity and reproducibility, and obtaining the lowest levels of detection in direct detection of messenger RNA isoforms generated by this mechanism without the need for PCR amplification (polymerase chain reaction). T[...]

01 Feb

STAFF III database published at Physionet
STAFF III database published at Physionet

The  STAFF III database have  gone public at Physionet! https://physionet.org/physiobank/database/staffiii/ The STAFF III database was acquired during 1995–96 at Charleston Area Medical Center (WV, USA) where single prolonged balloon inflation had been introduced to achieve optimal results of percutaneous transluminal coronary angiography (PTCA) procedures, replacing the typical series of brief inflations. The lead investigator Dr. Stafford Warren designed the study protocol together with Dr. Galen Wagner at Duke University Medical Center (Durham, NC, USA); Dr. Michael Ringborn (Blekinge Hospital, Karlskrona, Sweden) was responsible for data acquisition. The database consists of ECG recordings from 104 patients, accounting for substantial inter-patient variability in[...]

01 Feb

MRSI-based generation of nosological images for noninvasive therapy response assessment in preclinical GBM
MRSI-based generation of nosological images for noninvasive therapy response assessment in preclinical GBM

Nuria Arias Ramos from GABRMN-UAB, research group coordinator of Unit 25 of NANBIOSIS, presented on January 30th, an oral communication at the youngSMIN | young Spanish Molecular Imaging Network Meeting. The title of the communication is “Multi slice MRSI-based generation of nosological images for noninvasive therapy response assessment in preclinical GBM”, written by Nuria Arias-Ramos, SilviaLope-Piedrafita, Victor Mocioiu, Margarida Julià-Sapé, Carles Arús and Ana Paula Candiota. The work is basically centered in extending the preliminary GABRMN study based on MRSI  acquired in a preclinical glioblastoma (GB), both under treatment and control, with pattern recognition and source extraction for noninvasive therapy[...]

31 Jan

Computing in Cardiology President's Newsletter - 2017
Computing in Cardiology President’s Newsletter – 2017

Pablo Laguna, Scientific Director of Unit 27 of NANBIOSIS and President of  CinC (2015-2018), presents the details of CinC 2017 in the Computing in Cardiology, which shall be held in Rennes, France, September 24-27 Dear CinC Attendee, One more year has passed and the time to plan the annual conference has arrived.  To help you with this, I would like to bring you an update on relevant aspects related to CinC-2017, including dates, deadlines and events.  I would also like to update you on initiatives, some just consolidating recent developments, such as the Clinical Needs Translational Award (CTA), the Specia[...]

30 Jan

NANBIOSIS at the 10th Annual Conference of Technological Platforms of Biomedical Research
NANBIOSIS at the 10th Annual Conference of Technological Platforms of Biomedical Research

On March 7 and 8, 2017, the “X Conferencia Anual de las Plataformas Tecnológicas de Investigación Biomédica: Medicamentos Innovadores, Nanomedicina, Tecnología Sanitaria y Mercados Biotecnológicos”  will be held in Madrid.  Several aspects of innovation in the National Health System will be addressed, from a national and international perspective of public-private collaboration. On Wednesday, March 8 at 9:30 am, Jesús Izco, Coordinator of NANBIOSIS, will explain the opportunities offered by  the ICTS NANBIOSIS as a Network of Excellence for Research and  in Biomedicine,  especially in the fields of nanomedicine and biomaterials. The meeting, which brings together more than 300 scientists and[...]

23 Jan

Nanbiosis - A photonic endoscope to improve the colon cancer diagnosis
A photonic endoscope to improve the colon cancer diagnosis

Last 18th and 19th January, the Jesús Usón Minimally Invasive Surgery Centre attended the kick of meeting of the European project “Multimodal highly-sensitive PhotonICs endoscope for improved in-vivo COLOn Cancer diagnosis and clinical decision support” (PICCOLO, the English abbreviation), held in Bilbao. This project proposes a new compact, hybrid and multimodal photonics endoscope based on Optical Coherence Tomography (OCT) and Multi-Photon Tomography (MPT) combined with fluorescence technology. Colorectal cancer represents around one tenth of all cancers worldwide. Early and accurate diagnosis and precise intervention can increase cure rate up to 90%. The multidisciplinary team, composed by Tecnalia Foundation, the project[...]

18 Jan

Nanomedicine in B·Debate Fighting Blindness by Unit 10 of NANBIOSIS
Nanomedicine in B·Debate Fighting Blindness by Unit 10 of NANBIOSIS

The recent published Newsletter of Institut of Màcula and the Barcelona Màcula Foundation: Research for Vision reported about the forum  B·Debate Fighting Blindness. Future Challenges and Opportunities for Visual Restoration, September 6-7 , that gathered more than thirty experts in the different areas related with blindness. The second Session, about Nanotechnology and Nanomedicine, was chaired by Jose Luis Pedraz, Scientific Director of Unit 10 of NANBIOSIS and Gustavo Puras Ochoa, researcher  of the group Nanobiocel, which coordinates Unit 10 of NANBIOSIS gave a lecture “Non-viral gene delivery for the treatment of inherited retinal disorders” : Many devastating blinding disorders that[...]

17 Jan

Multifunctional biomaterials and nanomaterials
Multifunctional biomaterials and nanomaterials: the new technological revolution.

CaixaForum Zaragoza, Wednesday, January 18th, 2017 at 7:00 pm: talk by Jesús Santamaría, Scientific Director of Unit 9 of NANBIOSIS, within the Conference Cycle: Technology, the permanent revolution Nanotechnology is the application of nanoscience and, in its modern conception, implies having the ability to design nanomaterials for a specific purpose and to control the manufacturing processes that allow them to have the desired characteristics (composition, size, shape, surface characteristics). This talk presents the developments in nanotechnology as a true technological revolution. The general concepts and the influence of nanotechnology in our lives shall be discussed with examples of recent advances,[...]