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The EVO-NANO project will allow testing the behavior of nanoparticles within a tumor

The CIBER-BBN-CIBBIM group, led by Dr. Simó Schwartz, coordinating NANBIOSIS U20. In Vivo Experimental Platform has been granted a FET Innovation project (Future and Emerging Technologies)  within the Horizon 2020 program. The EVO-NANO project aims to develop a virtual simulator, called NanoDoc, which will allow testing the behavior of nanoparticles within a tumor and with other nanoparticles.

It is a multidisciplinary project that will develop a consortium of European research centers with the aim of creating a platform available to everyone and at the forefront of Nanomedicine that facilitates the rapid development and testing of new treatments against cancer. “It will become an evolutive platform capable of autonomously offering innovative, efficient and adapted solutions that can also be transferred to other complex biomedical challenges,” explains Dr. Schwartz Jr.

Until now, it is unknown how the behavior of nanoparticles when they are injected in large volume and come into contact, for example, with the bloodstream. It is not known whether the fruit of the interactions between them and with the media will have a better or worse therapeutic efficacy. In the same way, its distribution in a tumoral environment is not known, if they affect more to one type of cells than to others, their behavior before cancer stem cells, etc.

“This simulator will help to understand how nanoparticles interact with each other and in a biological environment when they are injected, in a large volume, in a tumor or in any part of the body,” Dr. Schwartz Jr. adds. Nanoparticles that have an optimal behavior that will later be studied and validated in biological models in vitro and in vivo in breast and colon cancer stem cells.

In addition, the project has an industry partner, Pro Chimia Surfaces, which will promote a translation strategy that enables the arrival of new patients’ nanomedicaments.

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Conference on Nanotoxicity, next May 24, Parc Scientific of Barcelona

NANBIOSIS is organizing a Conference on Nanotoxicity in collaboration with Nanomed Spain and Materplat, next May 24 in the Parc Scientific of Barcelona, to debate about the efect of nanotoxicity of nanoparticles and nanotechnologies in health.

The increase of potential risks to health has created the new discipline of nanotoxicity, that is, the study of the toxicity produced by the effect of nanoparticles and nanomaterials. The objective of this day is to learn more about the lines that are being followed by researchers in the area of ​​nanotoxicity, the progress of different projects in this field, as well as existing tools to know and reduce the toxicity of nanoparticles and nanomaterials.

Nanotechnology intervenes in the design, production and use of structures and objects that have at least one of its dimensions in the scale of 100 nanometers or less. This science is allowing the achievement of advances in various areas with great repercussions for society.

However, manufactured nanoparticles can have properties and effects very different from those of the same materials in conventional sizes, which may pose new risks to the health of man and other species. Some nanoparticles, which are used as a vehicle for drugs to reach the desired cells in greater quantities, to reduce the side effects of the drug in other organs or both, have the same dimensions as certain biological molecules and can interact with them.

The increase of potential risks to health has created a new discipline, nanotoxicity, that is, the study of the toxicity produced by the effect of nanoparticles and nanomaterials. The objective of this day is to learn more about the lines that are being followed in research in the area of ​​nanotoxicity, the progress of different projects in this field, as well as existing tools to know and reduce the toxicity of nanoparticles and nanomaterials.

The event will count with the presentations of Jesús Izco, Executive Director of NANBIOSIS, Ibane Abasolo, Scientific Coordinator of NANBIOSIS U20 In Vivo Experimental Platform and Francisco Balas,Scientists of NANBIOSIS U09 Synthesis of Nanoparticles Unit

The assistance is free but it is necessary to register.
For further information, agenda and registration click here 
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Gene therapy in pseudohypoparathyroidism

In 1942, Albright and colleagues described the first hormone resistance syndrome, which they called pseudohypoparathyroidism (PHP) (1), patients had a specific phenotype consisting of short stature, central obesity, round face, short neck and brachydactyly, which is what that today we know like Albright Hereditary Osteodystrophy (AHO, Albright Hereditary Osteodystrophy).

Nanobiocel research group, coordinator of NANBIOSIS U10. Drug Formulation, is working on the project “Gene therapy in pseudohypoparathyroidism: experimental development based on CRISPR / CAS9 and non-viral vectors“. The objective of the project is to design and validate the ex vivo gene therapy protocol for the correction of known mutations in the GNAS gene, causing pseudohypoparathyroidism (PHP) type 1A and pseudoPHP, through the following operational objectives: (1) Validation of the model lymphoblasts (immortalized or not) for the application of gene therapy; (2) CRISPR / Cas trial design and vehicularization in non-viral vectors; (3) Identification and characterization of off-target insertions (if any) and (4) Confirmation through functional studies of the correct functioning of the protein obtained from the modified gene.
The project will be carried out by the following research groups: BioAraba of Molecular Epigenetics in rare diseases, led by Dr. Guiomar Pérez de Nanclares, in the OSI Araba – Txagorritxu, the group Nanobiocel, led by Jose Luis Pedraz at UPV/EHU, this group is part of CIBER-BBN and ICTS NANBIOSIS and the group of Professor Cesar Martin, Biofisika Institute (UPV/EHU, CSIC).
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Microfluidic technologies to study the cardiomyopathy processes of Duchenne’s disease

Ignacio Ochoa and Luis Fernandez, researchers of the AMB group of CIBER-BBN and I3A-University of Zaragoza, coordinator of NANBIOSIS U13. Tissue & Scaffold Characterization Unit, are working on the european project “CISTEM – HEART ON CHIP BASED ON INDUCED PLURIPOTENT STEM CELL TECHNOLOGY FOR PERSONALIZED MEDICINE” . They are developing heart on a chip microfluidic devices to study the cardiomyopathy process in the Duchenne muscular distrophy using microfluidic technologies.

CISTEM Kick-off Meeting was successfully held on 24th of January 2018 at Elvesys, Paris, France. Representative of the consortium organizations including academic institutions and industry representatives were participating in this meeting: BioSense Institute, Elvesys, Cherry Biotech, Universidad Zaragoza, BEOnChip and Jagiellonian University

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NANBIOSIS participates in the new Video “Technological Strategy MATERPLAT”

MATERPLAT, Technological Platform of Advanced Materials and Nanomaterials, premieres Youtube channel with a video in which it discloses the activities of the platform and how they try to help to promote the creation of a national ecosystem in the field of advanced materials and nanomaterials .

The video is also about one of the last major milestones of the platform: the elaboration of the Spanish Technological Strategy of Advanced Materials and Nanomaterials, in which NANBIOSIS has participated through its Coordinator, Jesus Izco, who leads the Materplat health innovation group.

Video “Technological Strategy MATERPLAT” 

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Nora Ventosa, Scientific Director of NANBIOSIS U6, presented the Smart4Fabry project to the compressed fluids community

Last  25th April, Nora Ventosa, Scientific Director of NANBIOSIS U6. Biomaterial Processing and Nanostructuring Unit, presented Smart4Fabry project to the compressed fluids community at the 12th International Symposium on Supercritical Fluids in Antibes, France.

This event is held every three years, gathering investigators from all domains with the aim to promote knowledge and applications of Supercritical Fluids.

According to the ISASF, International Society for Advancement of Supercritical Fluids, “a fluid is called “supercritical” when both its pressure and temperature are over its critical pressure and temperature. It is monophasic and exhibits specific properties, different from those of liquids and gases. Supercritical fluids have a high solvent power vis-à-vis many compounds, at the difference with compressed gases. This solvent power can be easily modified by changing the pressure, what permits to design very selective processes leading to high-quality products”.

 

 

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