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Posts Taged stem-cells

Scientific breakthrough against the problems of advanced age in fertility.

Researchers of CCMIJU. led by Javier G. Casado, Scientific Director of NANBIOSIS U14 Cell Therapy, are coauthors of the article “Extracellular vesicles derived from endometrial human mesenchymal stem cells enhance embryo yield and quality in an aged murine model” published by. Biology of Reproduction,

The study of the beneficial effect of endometrial stem cell exosomes on embryonic quality has been developed in NANBIOSIS U14 and in collaboration with U22 and U23

Advanced age is a risk factor undermining women’s fertility. Hence, the optimization of assisted reproduction techniques is an interdisciplinary challenge that requires the improvement of in vitro culture systems. Here, we hypothesize that supplementation of embryo culture medium with extracellular vesicles from endometrial-derived mesenchymal stem cells (EV-endMSCs) may have a positive impact on the embryo competence of aged oocytes. In this work, 24 weeks old B6D2 female mice were used as egg donors and in vitro fertilization assays were performed using males from the same strain (8–12 weeks); the presumptive zygotes were incubated in the presence of 0, 10, 20, 40, or 80 μg/ml of EV-endMSCs. The results from the proteomic analysis of EV-endMSCs.

In summary, the supplementation of embryo culture medium with extracellular vesicles from endometrialderived mesenchymal stem cells increases the quality of aged embryos.

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Stem cells for improving the biocompatibility of surgical meshes

JUMISC carried out an in vitro and in vivo study focused in the use of MSCs -coated surgical meshes to counteract the inflammatory response commonly observed after implantation.
Surgical meshes are medical devices traditionally used to solve hernias and prolapsed organs pathologies that may cause inflammation and foreign body reactions, causing pain and discomfort to the patient.
According to this, the JUMISC financed a R&D project to evaluate if MSCs may provide an anti-inflammatory environment after surgical implantation.
Magnetic resonance imaging, laparoscopic evaluation and histological studies were performed to evaluate safety aspects and its future clinical application as a bioactive material. The in vivo results demonstrated that they fulfill safety aspects and non-adverse effects.
The results have been published in Acta Biomaterialia, the second best journal in its area, whose authors are Rebeca Blázquez, Francisco Miguel Sánchez-Margallo, Verónica Álvarez, Alejandra Usón y Javier G. Casado. Moreover, according to the philosophy of JUMISC to promote the innovation and the quality of the patient life, from these results emerged an invention which is protected as a patent.
Finally, this project will continue and future experiments will be developed in a clinically relevant animal model for the extrapolation of the results to a clinical scenario.

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Images of the MSC-s coated surgical meshes obtained by microscopy

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