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Posts Taged nanobiosensors

Nanobiosensors for the monitoring of brain lesions

On March 11, the first meeting of the European project ABISens “Monitoring of Acquired Brain Injury and recovery biomarkers by the combined label-free nanoSensing of multiple circulating molecules” was held at the facilities of the Catalan Institute of Nanoscience and Nanotechnology ICN2.

This new initiative aims to offer a new platform for photonic nanobiosensors that allows the identification and quantification of multiple brain biomarkers in blood with high sensitivity and in a short time. The new platform will use nanophotonic circuits in combination with the chemistry of oligonucleotides.

Two units of NANBIOSIS participate in the project Unit 4 Biodeposition and Biodetection Unit, led by Laura Lechuga, as coordinator of the EURONANOMED-III project and recenttly incorporated unit 29 of Oligonucleotide Synthesis Platform lead by Ramón Eritja. The project, which will also work with researchers from the Maugeri Spa Società Benefit Clinical Institute (ICSM) of Italy and researchers from the University of Bordeaux (UNIBO) in France, responds to the clinical need to evaluate patients after brain injuries that cause disabilities serious. The final tool developed after the project will be validated in samples of 40 patients with brain injury.

The project, which will last for 3 years and has a budget of more than € 700,000, is financed by the call for transnational research projects in nanomedicine, within the framework of the European research network ERA-NET Cofund EURONANOMED III (2016- 2021) “European Innovative Research & Technological Development Projects in Nanomedicine (ENM III)”. At a national level, the Carlos III Health Institute will be the entity that will finance the coordinating group of CIBER-BBN

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Interferometric nanoimmunosensor for label-free and real-time monitoring of Irgarol 1051 in seawater

As a result of a collaboration in the context of the EC-FP7 program OCEAN 2013, NANBIOSIS Unit 2 Custom Antibody Service (CAbS) and  Unit 4. Biodeposition and Biodetection,  the research groups coordinating this NANBIOSIS Units have recently published an article titled “Interferometric nanoimmunosensor for label-free and real-time monitoring of Irgarol 1051 in seawater” in the scientific magzine  iosensors and Bioelectronics.

The CIBER-BBN-ICN2 group  Nanobiosensors and Bioanalytical Applications, led by Prof. Laura Lechuga has developed the immunosensor that is described in the article using immunoreactive, produced in the group of  Nanobiotechnology for Diagnostics Group (Nb4D), led by Prof. Pilar Marco, with the collaboration of CAbS, for Irgarol 1051. This compound is an alguicide used as an additive in the paintings of ships. Over time, the compose is being released  into the marine environment causing a risk to the ecosystem and to the health of the population.

In the article, an interferometric nanobiosensor for the specific and label-free detection of the pollutant Irgarol 1051 directly in seawater has been settled. Due to the low molecular weight of Irgarol pollutant and its expected low concentration in seawater, the sensor is based on a competitive inhibition immunoassay. Parameters as surface biofunctionalization, concentration of the selective antibody and regeneration conditions have been carefully evaluated. The optimized immunosensor shows a limit of detection of only 3 ng/L, well below the 16 ng/L set by the EU as the maximum allowable concentration in seawater. It can properly operate during 30 assay-regeneration cycles using the same sensor biosurface and with a time-to-result of only 20 min for each cycle. Moreover, the interferometric nanosensor is able to directly detect low concentrations of Irgarol 1051 in seawater without requiring sample pre-treatments and without showing any background signal due to sea matrix effect.

Article of referencehttps://doi.org/10.1016/j.bios.2018.05.044

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Prof. Laura Lehuga, new Associate Editor at Analyst Editorial Board

Laura Lechuga, Scientific Director of NANBIOSIS Unit 4 Biodeposition and Biodetection Unit, at Catalan Institute of Nanoscience and Nanotechnology,  has joined the Analyst Editorial Board as an Associate Editor from today.

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions and the applications of those discoveries, unconfined by traditional discipline barriers

Laura Lechuga is the CSIC Research Professor at the Catalan Institute of Nanoscience and Nanotechnology, Spain. She is the leader of the CIBER-BBN-ICN2 Nanobiosensors and Bioanalytical Applications Group, which focusses on the technological development of nanophotonic biosensors, their integration into portable lab-on-a-chip platforms and their application in clinical and environmental diagnostics. Professor Lechuga gained her PhD in chemistry in 1992 from the Universidad Complutense de Madrid. Between 2012 and 2015 she was an adjunct professor at the University of Norway within their department of Physics and Technology at the Artic. She has also been a distinguished visiting professor at the School of Electrical and Computer Sciences of the Universidade Estadual de Campinas (Brazil) since 2013.

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