The service has a standard immunization protocol that includes monthly inoculations with Freund adjuvant during a period of 4 months. This protocol can be adapted to final project objective.
To determine the progress of the immune response, a bleed is taken after 10 days after the second immunization to obtain antiserum and the titer is determined through ELISA.
Among the controls is included obtaining preimmune serum from the animals obtained from the blood previously to the first injection. At the end of the process 50-70 mL of hyperimmune serum is obtained per animal from final production bleed.