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FORUM ON NANOMEDICINE APPLICATIONS IN DRUG DELIVERY AND TARGETING

ICTS Nanbiosis, together with Nanomed Spain has organized a forum with companies on NANOMEDICINE APPLICATIONS IN DRUG DELIVERY AND TARGETING that will take place next June 21 in Barcelona (Barcelona School of Management, Universitat Pompeu Fabra – C / Balmes, 132-134)

The forum will be presented through 2 sessions:
1- Short interventions of the latest advances and developments in the research lines developed by the groups and NANBIOSIS Units and description of the needs and demands of the industry in that area.
2- Bilateral meetings of about 15 minute company-group / NANBIOSIS Unit to identify possible collaborations.

The event will include the participation of the CDTI that will present the CDTI Financing Instruments for the use of Singular Scientific Technical Facilities and public-private collaboration

Registration is free and will be by order of registration until the capacity is exhausted.

Program and registration

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Prof. A. Villaverde interviewed by CIBER-BBN Bulletin

Prof. Antoni Villaverde, Strategy Director of NANBIOSIS U1. Protein Production Platform (PPP), in an interview for the CIBER-BBN Bulletin, speaks about his research group, coordinanting NANBIOSIS u1 and the benefits of belonging to a research structure like CIBER.

“The PPP – explains Prof. Villaverde – was generated within the group, but is currently a platform that has been gaining its own entity and structure, and has received the ISO certification granted by AENOR. Neus Ferrer-Miralles is the Scientific Director and Paolo Saccardo the technical coordinator. The objective of the activity developed by the PPP is based on supporting CIBER groups in the production and purification of recombinant proteins within the field of nanomedicine. The fact that this service has emerged within a powerful research group allows the accumulated knowledge and experience to directly revert to the needs in this field within the area of nanomedicine in our country. Therefore, with the aim of reaching society, in addition to the CIBER, we also provide service to public and private entities dedicated to research and pharmaceutical companies”.

According to Toni Villaverde “The incorporation of the group to the CIBER-BBN has represented a clear and deap positive impact on our activities, at a collaborative level, which has greatly enriched our scientific and methodological capabilities and which has allowed a multidisciplinary scientific activity, which otherwise It would not have been possible. Since the beginning of the CIBER, we have carried out punctual collaboration activities with various groups of CIBER, and we have generated more stable collaborative structures that allow scientific developments in the medium-long term. Among the latter, it is necessary to highlight the collaboration with the group of Dr. Mangues and Dras. Isolda Casanova and Virtudes Céspedes,- coordinating NANBIOSIS U18.Nanotoxicology Unit, Profs. Veciana y Ventosa, coordinatinatin NANBIOSIS U6. Biomaterial Processing and Nanostructuring Unit, as well as of the group coordinated by Prof. Schwartz and Dr. Abasolo” –NANBIOSIS U20. In Vivo Experimental Platform-.

In this interview, Dr. Villaverde reviews the main research lines and projects that the research group at the Institute of Biotechnology and Biomedicine of the Autonomous University of Barcelona, coordinator of the NANBIOSIS U1.PPP, is currently developing (nanostructured protein materials as therapeutic anti-inflammatory agents, nano and protein microstructures for drug delivery in targeted therapies and new drugs for rare diseases, nanoconjugates based on self-assembling proteins for targeted cancer therapy, self-assembling and nanostructured protein drugs, produced in recombinant form and based on very potent toxins, for targeted molecular therapy of cancer… and much more…) .

For further information: click here

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Nosological images of response to therapy based on metabolomic information by magnetic resonance

Ana Paula Candiota, Scientific Coordinator of NANBIOSIS U25. NMR: Biomedical Applications I. is givin a talk about “Nosological images of response to therapy based on metabolomic information by magnetic resonance: a step beyond the standard image” next June 6, on Barcelona.

According to Dr. Candiota, “The reliable characterization of the treatment response in glioblastoma (GB) is a key factor in improving the survival and prognosis of patients. Image (MRI) and spectroscopic image (MRSI) by magnetic resonance respectively provide morphological and metabolotic profiles of GB, but in general they are not as robust to produce surrogate biomarkers in response to short-term therapy. One of our objectives is to try to provide clinicians with a reliable way to follow the response to therapy in a more adjusted temporal window for changes or adaptations of the therapy, and in a more early way than the one currently performed using MRI. This part of the course will emphasize the potentiality of the systems of patterrn recognition / machine learning to produce ‘nosological images’ to recognize in a robust way the response to temozolamide (TMZ) therapy in preclinical GB (glioblastoma GL261 murine model in the immunocompetent strain C57 / BL / 6), based on the information of the magnetic resonance spectroscopic images. Despite being developed on a preclinical model of pathology, these techniques have a clear translational potential and could in the future improve the management of the different aspects of the treatment of patients”.

The talk will take place in the Conference: Nanotechnology applied to medicine as a learning resource for healthcare professionals, organized by Union Consorci Formació in Barcelona (Parc Sanitari Pere Virgili, Edifici Montseny planta -1).

The objective of the event is to summarize the most significant advances that have been made in this field, both at the level of development of nanomaterials, as well as in the most relevant applications of the different nano-pharmaceuticals that are on the market, to end up highlighting the future challenges to which faces nanomedicine to increase the efficiency and specificity of nanomedication.

Programa e inscripciones: Inscription is free but the number of places is limited.

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Oocyte holding in the Iberian red deer: Effect of initial oocyte quality and epidermal growth factor addition on in vitro maturation

José Mijares Gordún, and Francisco M. Sánchez Margallo, Scientific Director and Scientific Coordinator of NANBIOSIS U23. Asisted Reproduction, are co-authors of de article “Oocyte holding in the Iberian red deer (Cervus elaphus hispanicus): Effect of initial oocyte quality and epidermal growth factor addition on in vitro maturation“, published by Reproduction in Domestic Animals.

The scientists have demonstrated that oocyte holding can be used in Iberian red deer oocytes. Interestingly, EGF addition increases the oocytes’ meiotic competence in immediately matured oocytes but not after oocyte holding depending upon initial oocyte quality.

The investigation has been continued in the assisted reproduction laboratory of unit 23 of NANBIOSIS, equipped with two intracitoplasmatic micromanipulation equipment of the latest generation with IMSI, Laser and Oosight system, embryo biopsy systems, vision systems of the mitotic spindle, with flow cabinets with stereo-microscopes and heated plates, incubators with different gasses systems, equipment and cryopreservation freeze gamete and embryo, among others.

For further information: DOI: 10.1111/rda.13099

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Carbon-gold bonds for robusts molecule-electrode junctions

Marta Mas-Torrent, Jaume Veciana, and Nuria Crivillers, scientists of the research group NANOMOL, coordinating NANBIOSIS U6. Biomaterial Processing and Nanostructuring Unit, are co-authors of the article “Carbon-gold bonds for robusts molecule-electrode junctions” by Journal of the American Chemical Society -JACS-.

The researchers have studied the behaviour of an organic radical as a molecular wire formed by a covalent carbon-gold bond between the molecule and two electrodes. The molecule-metal junction is more stable and gemotrically better defined than its predecessors, in which other functional groups were used. This improvement opens up new horizons in the fabrication of novel electronic devices with applications in the Molecular Electronics field.

Article of reference:

Francesc Bejarano, Ignacio Jose Olavarria-Contreras, Andrea Droghetti, Ivan Rungger∥, Alexander Rudnev⊥, Diego Gutiérrez, Marta Mas-Torrent, Jaume Veciana, Herre S. J. van der Zant, Concepció Rovira, Enrique Burzurı́, and Núria Crivillers. Robust Organic Radical Molecular Junctions Using Acetylene Terminated Groups for C–Au Bond Formation. J. Am. Chem. Soc., 2018, 140 (5), pp 1691–1696

DOI: 10.1021/jacs.7b10019

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Mesenchymal stem cells or exosomes with fibrin glue mesh fixation modulates the inflammatory reaction in a murine model of incisional hernia

Javier García Casado, Scientific Director of NANBIOSIS U14, Cell Therapy Unit, and Francisco Miguel Sánchez Margallo, Scientific Director of CCMIJU, are co-author of the publication “Fibrin glue mesh fixation combined with mesenchymal stem cells or exosomes modulates the inflammatory reaction in a murine model of incisional hernia” by Acta Biomaterialia.

In vitro experiments were performed by the ICTS Nanbiosis (Unit 14. Cell therapy at CCMIJU). Exosomes characterization was performed by the ICTS Nanbiosis (Unit 6: Biomaterial processing and Nanostructuring Unit). In vivo experiments were performed by the ICTS Nanbiosis (Unit 22. Animal housing at CCMIJU).

The study has demonstrated a significant increase of anti-inflammatory M2 macrophages and TH2 cytokines when MSCs or exo-MSCs were used. Moreover, the analysis of MMPs, TIMPs and collagen exerted significant differences in the extracellular matrix and in the remodeling process. The in vivo study suggests that the fixation of surgical meshes with FG and MSCs or exo-MSCs will have a beneficial effect for the treatment of incisional hernia in terms of improved outcomes of damaged tissue, and especially, in the modulation of inflammatory responses towards a less aggressive and pro-regenerative profil,

The implantation of surgical meshes is the standard procedure to reinforce tissue defects such as hernias. However, an exacerbated and persistent inflammatory response secondary to this implantation is frequently observed, leading to a strong discomfort and chronic pain in the patients. In many cases, an additional surgical intervention is needed to remove the mesh.

This study shows that mesenchymal stem cells and their exosomes, combined with a fibrin sealant, can be used for the successful fixation of these meshes. This new therapeutic approach, assayed in a murine model of incisional hernia, favors the modulation of the inflammatory response towards a less aggressive and pro-regenerative profile

For further information: DOI: https://doi.org/10.1016/j.actbio.2018.02.014.

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NANBIOSIS collaborates in the dissemination of science and triumphs in the Pint of Science Festival

On May 16, scientists from two units of NANBIOSIS filled the pubs, not to talk about football but about science.

According to Jorge Bueno, Coordinator of Pint of Science in Spain, at the Vanguard “Science is also culture, just as we go to the bar to talk about football or politics, we can also talk about science, we want people to conceive science as part of society ”

In the cafe of the civic center of the Casa Orlandai in Barcelona, Eli Prats, a researcher of NANBIOSIS U8. Micro – Nano Technology Unit, explains her group has developed graphene electrodes, a material with unique properties, that can monitor the activity of the brain in a less invasive than conventional ones. “We have tested it in rats and we have discovered that graphene can detect very poorly studied brain waves, which occur just before dying, just before an attack of epilepsy or before a migraine attack.” The researcher shows a sample of the tiny electrodes, which passes from hand to hand in the pub. “It’s still just an idea, but theoretically in the future these electrodes, placed on a person’s brain, could send a signal to a tablet and predict when they will suffer an attack of epilepsy,” adds Eli Prats.

Esther Pueyo, researcher of NANBIOSIS, U27. High Performance Computing, in the Drinks and Pool Aranda pub of Zaragoza explained that “Chronological age does not matter, but the biological one does, not all hearts age equally” and she tried to answer the questions why do I look older? What other people of my age? Will this have consequences? To show the tiny tissues Esther and researchers around her commonly work with, biopsies were collected from a cow heart and examples of the experimental and theoretical analyses they conduct were illustrated.

Throughout Spain, a total of 730 scientists have participated giving talks within the Pint of Science Festival, in 56 cities, together with around 400 organizers, all of them volunteers.

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Laparoendoscopic Single-Site Surgery Using Handheld Robotic Device

Francisco Miguel Sánchez Margallo, Scientific Director of CCMIJU and NANBIOSIS U21. Experimental operating rooms, is co-author of the publication “Assessment of Postural Ergonomics and Surgical Performance in Laparoendoscopic Single-Site Surgery Using a Handheld Robotic Device“, by Surgical Innovation (SAGE journal).

The study results show a positive learning curve in ergonomics and surgical performance using the robotic instrument during LESS surgery. This instrument improves the surgeon’s body posture and the needle positioning errors. The use of the robotic instrument is feasible and safe during LESS partial nephrectomy and sigmoidectomy procedures.

The study has been develloped with surgical facilities of high technology that allow in vivo efficacy assays of drugs, nanomedicines, biomaterials and others, performed at unit 21 of NANBIOSIS.

For further information: DOI: 10.1177/1553350618759768

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NANBIOSIS-ICTS: a tool in additive printing for biomedical applications.

On Friday, May 18, the Conference&Workshop “Opportunities in additive printing. Health Sector” will take place in the Assembly Hall of the Higher Technical School of Industrial Engineers and Telecommunications of the Public University of Navarra.

The event is been organized by the Cluster Functional Print and ANAIT (Association of Engineering Companies, Technical Studies and Technological Services), in collaboration with the Cátedra Industria 4.0 of CITI Navarra and UPNA with the aim of sensitizing the industry and its professionals of the open business opportunities with the development in additive printing, as well as the need for training in this field.

Jesús Izco, Executive Director of NANBIOSIS, will present the ICTS of production and characterization of biomaterials and nanomaterials as a tool in additive printing for biomedical applications.

Program and inscriptions

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Nanotechnology, gene therapy, omics therapies and ‘big data’

Nanotechnology, gene therapy, omics therapies and ‘big data’ were the topics discussed in the Forum on Emerging Technologies oganized on May 8 by nanotechnology, gene therapy, omics therapies and ‘big data’ were the topics discussed in the I Forum on Emerging Technologies held on May 8, organized by the CIBER Internationalization Platform, of which the CIBERER, the CIBER-BBN and the CIBERES.

The objective of this event, structured in sessions of presentations and scientific debates about the types of technologies addressed, was to promote the exchange of ideas and scientific knowledge with the aim of generating new collaborations among the CIBER research groups such as participation in transversal projects or the development of cutting-edge technologies.

NANBIOSIS was represented by Pablo Laguna (Unit 27, High Performance Computing), Laura Lechuga (Unit 4, Biodeposition and Biodetection Unit), José Luis Pedraz (Unit 10, Drug Formulation) and Rosa Villa (Unit8, Micro – Nano Technology Unit)

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