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Biomaterials & nanomaterials production - Services

Biomaterials & nanomaterials production – Services

U8-S05. Deposition of thin films (Polyimide, Parylene) for the fabrication of flexible devices or encapsulation purposes (On-site&Remote) OUTSTANDING.

Deposition of thin films (Polyimide, Parylene) for the fabrication of flexible devices or encapsulation purposes (On-site&Remote) OUTSTANDING.

Deposition of Polyimide (PI-2611) via spin-coating for the fabrication of flexible free-standing structures.
Conformal deposition of Parylene (different types available)

Customer benefits

  • Possibility to access to the PI deposition system in self-service mode to adapt the process to the customer needs.
  • Different Parylene types available for deposition to match customer needs

Target customer

Research groups and SMEs

References

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U8-S06. Encapsulation or fabrication of 3D strcutures via 3D printing.

Encapsulation or fabrication of 3D strcutures via 3D printing.

Fabrication of 3D structures using a dual extrusion 3D printer that delivers high-quality, composite-ready performance – in a smaller footprint

Customer benefits

Possibility to access to the 3D printing equipment in self-service mode to adapt the process to the customer needs.

Target customer

Research groups and SMEs

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U9-S06. Consultancy

Consultancy

The unit can provide advice about the most suitable synthesis method to obtain nanoparticles and/or the most convenient characterization techniques according to the customers´ needs

Customer benefits

The customer will benefit from the experience of the facility to help and guide in the selection of the most suitable synthesis approach depending on the customer´s needs.

Target customer

Material suppliers, pharma industry, research laboratories and research groups with interests in biomedicine, nanotoxicology, drug delivery, development of new materials for catalysis, encapsulation, delivery.

Related projects

  1. Laser Pyrolysis For The Development Of Inorganic Nanoparticles –10/2017 – 09/2018. Funding Entity: TEIJIN LIMITED.
  2. Desarrollo de fibras, polímeros y cerámicas con propiedades foto-catalíticas intrínsecas. 23/11/2021-23/11/2024. Funding Entity: NUREL, S.A.
  3. Investigación y desarrollo de nuevas metodologías de análisis estructural de papel reciclado y su aplicación a la optimización de papeles. 01/09/2021-31/08/2023. Funding Entity: S.A. INDUSTRIAS CELULOSA ARAGONESA
  4. Preparación Y Caracterización De Superficies Filtrantes Conteniendo Nanopartículas Basadas En Cu En Superficie 09/2020- 11/2020. Funding Entity: VISCOFAN, S.A. PI: Jesús Santamaría
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U8-S04. Graphene growth services (On-site&Remote) OUTSTANDING

Graphene growth services (On-site&Remote) OUTSTANDING

CVD graphene growth on copper foils and transfer of CVD graphene to rigid/flexible substrates.

Customer benefits

Adaptable platform for electrical characterization of microelectrodes to meet customer needs

Target customer

Research groups and SMEs

References

  • Masvidal-Codina E, Illa X et al., Nature Materials 18 (2019) 280-288
  • Bonaccini Calia et al., Nature Nanotechnology 17 (2022) 301-309
  • Brosel-Oliu et al. Small (2023) 2308857
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U7-S11. Contact angle

Contact angle

The Contact angle service of U7 is specialized in the characterization of surface-liquid interactions at the macro-scale. One can measure contact angle of different liquids and determine the surface free energy of different surfaces under investigation, as well as the wettability properties of different surfaces or different coatings.

Customer benefits

Our Contact angle service benefits from being part of a bioengineering-specialized research centre, providing wide knowledge in the treatment of different surfaces to tailor their properties according to the final bio-application. We offer custom services, assuring close and direct interaction with the client, to meet conclusive results and high-quality needs.

Target customer

Our target customers are researchers in the field of bioengineering or R&D departments of biotech companies which want to test, characterize, or compare different substrates, materials or prototypes.

Additional information


Contact angle measurement of diiodomethane on silicon wafer.

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U9-S05. Generation and control of nanoparticle aerosols

Generation and control of nanoparticle aerosols

This Unit offers the possibility of generating nanoparticle aerosols from a large variety of liquid suspensions or nanosized powders. Our patented technology allows a reliable aerosol generation from any preformed micro or nanoparticle powder. These aerosols with known and reproducible characteristics can then be used in wide variety of applications.
For determining the particle size and concentration in aerosol phase, several nanoparticle aerosol spectrometers are also available. These allow a real-time determination of the concentration of particulate matter in air streams and environments from sizes down to 5 nm.
Also, the Unit is able to identify nanosize matter from aerosols using a reliable, ultrasensitive identification in diverse matrices, based in introducing trace amounts of labels (eg. rare earth oxides or flurorophores).

The following devices are available through this service:

  • Liquid-phase aerosol generators.
  • Nanoparticle aerosol generator from powder samples.
  • Fluidized bed aerosol generator.
  • Scanning Mobility Particle Sizer (Grimm Aerosol) for nanoparticle aerosols from 5 nm to 10 um.
  • Optical Particle Sizer (Grimm Aerosol) for particulate aerosols from 1 um to 400 um.
  • Environmental exposure chamber with controlled nanoparticle concentration.

Customer benefits

This service is able to produce stable and reliable aerosol streams with nanoparticles of a large variety of origins, e.g., on exposure tests with environmental models or for development and validation of methods for sampling and monitoring of airborne matter.

Target customer

Researchers with interests in environmental modelling, nanoparticle aerosol distribution, pharmaceutical companies for aerosolized drug formulations, development of clinical aerosol formulations, testing of respiratory devices and research in filtering units.

Additional information

https://nfp.unizar.es/wp-content/uploads/2019/07/B4-figure1.jpeg SEM and TEM images of the matter captured from the powder aerosol generator

Selected References:

  1. Fast and simple assessment of surface contamination in operations involving nanomaterials. Clemente, A. et al. J. Hazard. Mater. 363, 358-365, (2019)
  2. A Versatile Generator of Nanoparticle Aerosols. A novel tool in Environmental and Occupational Exposure Assessment. Clemente, A., et al., Sci. Total Environ. 625, 978-986, (2018).
  3. Modelling the size distribution in a fluidized bed of nanopowder. Fabre, A. et al. Environ. Sci. Nano, 4 (3), 670-678 (2017).

Patents:

  • Generador de aerosoles nanoparticulados y procedimiento de generación de aerosoles en continuo asociado a dicho generador J. Santamaria, F. Balas, M.P. Lobera, A. Clemente. Patent Appl. Number: PCT/ES2018/070027 Patent holder entity: University of Zaragoza, VITROCELL SYSTEMS GMBH
  • Method for generating an inhalable micro-or nanoparticulate aerosol from a dry-powdered biocompatible material. J. Santamaria, M.P. Lobera, B. Arauzo, F. Balas, A. Clemente, Spanish Patent EP22382574.
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U9-S04. Microfluidics and microwave-assisted production of nanoparticles

Microfluidics and microwave-assisted production of nanoparticles

Conventional batch reactors may suffer from limitations due to the inefficient heat and mass transfer that makes it very difficult to achieve an accurate control on the synthesis conditions. This has a direct effect on key aspects such as reproducibility, selectivity and scalability. In fact, one of the bottlenecks in the development of Nanotechnology lies in the lack of precise synthesis methods capable of a scaled up production.
Continuous flow reactors based on microfluidic principles offer potential solutions to the aforementioned concerns. The exquisite control afforded by microfluidic reactors enables continuous production of nanomaterials with targeted sizes, shapes and composition. Moreover, the combination with microwave reactors can accelerate the stabilization of metastable phase due to the fast and selective heating supplied by this electromagnetic irradiation.

Customer benefits

The customer can benefit from the Unit´s expertise on the design of versatile microfluidic platforms to produce a broad library of nanostructures in a continuous fashion, often with a strong reduction of processing times with respect to the corresponding batch process. The Unit also offers unprecedented flexibility in terms of tuning the reaction atmosphere. Access to microwave reactors to perform fast heating reactions will be another asset to optimize specific synthesis and/or reactions in liquid media.

Target customer

Pharmaceutical companies, material suppliers, research groups pursuing a controlled and potentially scalable production of materials.

Additional information

https://nfp.unizar.es/wp-content/uploads/2019/07/A3-screenshot-24jul19-170853.025781151.png

Selected References:

  1. R. Quirós-Ovies, et al., Microwave-driven exfoliation of bulk 2H-MoS2 after acetonitrile pre-wetting produces large-area ultrathin flakes with exceptionally high yield, ACS Nano, 17, 5984-93 (2023).
  2. Manno, R., RanjaN, P., Sebastian, V., Mallada, R., Irusta, S., Upendra K. Sharma, U.K., Van der Eycken E.V., Santamaria, J., Continuous Microwave-Assisted Synthesis of Silver Nanoclusters Confined in Mesoporous SBA-15: Application in Alkyne Cyclizations. Chem. Mat. 32, 7, 2874–2883, (2020).
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U9-S03. Characterization of nanoparticles

Characterization of nanoparticles

The unit has access to different advanced characterization equipment including N2 adsorption (ASAP), porosimetry, several chromatography techniques (GC, HPLC, UPLC, GC-MS), Microwave Plasma-Atomic Emission Spectroscopy (MP-AES) for elemental analysis, UV-VIS spectroscopy, DSC, NTA, TPD/TPR and TGA. On the other hand, there is access to magnetic characterization by SQUID and VSM, Raman Spectroscopy (Alpha300R WITEC Raman confocal microscope), Infrared spectroscopy FTIR (Vertex 70 Bruker) and Fluorescence spectrometry (Perkin-Elmer, LS-45). Scanning Electron Microscopes (SEM) (including 3 dual-beam models); Transmission Electron Microscopes (TEM) (including two ultra-high resolution models with aberration corrector lens: TITAN 80-300 y TITAN CUBE 60-300). X-ray Diffractometers (specialized for powdered, low-angle and heating configurations), 2 X-ray Photoemission Spectrophotometers (XPS).

Customer benefits

The customer will be benefit from the expertise of the Unit´s members to carry out a complete characterization of nano and microstructured materials, ranging from polymeric, biological to inorganic compositions, including morphological, chemical, structural, optical, magnetic properties.

Target customer

Companies, material suppliers, pharma laboratories, research laboratories, conservation, medical laboratories.

Additional information

Selected Reference:

N. Miguel-Sancho, G. Martinez, V. Sebastian, A. Malumbres, I. Florea, R. Arenal, M. Carmen Ortega-Liebana, J.L. Hueso, J. Santamaria, Pumping Metallic Nanoparticles with Spatial Precision within Magnetic Mesoporous Platforms: 3D Characterization and Catalytic Application, Acs Applied Materials & Interfaces, 9 (2017) 41529-41536.

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U9-S02. Synthesis of nanoparticles by wet methods and microfluidic technology

Synthesis of nanoparticles by wet methods and microfluidic technology

This facility is able to draw on a wide range of nanoparticles fabrication techniques by wet chemical approaches including the use of co-precipitation techniques, light-assisted co-deposition methods, hydrothermal, solvothermal synthesis. It also entails the use of alternative microfluidic reactors to achieve a higher control and reproducibility of targeted nanoparticles.

Customer benefits

The customers will benefit from the expertise of researchers to synthesize a wide variety of nanomaterials and nanocomposites including polymeric, magnetic, plasmonic, core-shell, nanorods, nanostars, nanoalloys of noble metal, transition metal and inorganic oxides. Microfluidic technology can be also designed to optimize specific demands of continuous production or in situ encapsulation of cargoes of interest.

Target customer

Companies, nanoparticle suppliers and research groups can benefit from custom-designed delivery of an ample portfolio of nanoparticle designs that can be applied in biomedicine, sensing, toxicology, delivery, decontamination and energy applications.

Additional information

Selected References:

  1. M.C. Ortega-Liebana, J.L. Hueso, R. Arenal, J. Santamaria, Titania-coated gold nanorods with expanded photocatalytic response. Enzyme-like glucose oxidation under near-infrared-illumination, Nanoscale, 9 (2017) 1787-1792.
  2. B. Rubio-Ruiz, A.M. Perez-Lopez, L. Uson, M.C. Ortega-Liebana, T. Valero, M. Arruebo, J.L. Hueso, V. Sebastian, J. Santamaria, A. Unciti-Broceta, In Cellulo Bioorthogonal Catalysis by Encapsulated AuPd Nanoalloys: Overcoming Intracellular Deactivation, Nano Letters, 23 (2023) 804-811.

Related Research Projects:

CADENCE – Catalytic Dual-Function Devices Against Cancer
09/2017 – 08/2022. Funding Entity: European Union H2020 – Advanced Grant. PI: Jesus Santamaria

https://www.nanbiosis.es/wp-content/uploads/2015/05/U9.-Synthesis-of-Nanoparticles-Samples.jpg

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U9-S01. Synthesis of nanoparticles by laser induced-pyrolysis

Synthesis of nanoparticles by laser induced-pyrolysis

The unit provides an automated system for the synthesis of nanoparticles using laser-induced pyrolysis of chemical precursors in gas and/or aerosol phase, which enables the generation of different type of nanoparticles. This service includes the possibility of selecting different feeding precursors either in gas, liquid or resuspended solids. The unit can also explore solid or liquid recollection of nanoparticles.

Customer benefits

This service can be quite convenient for generation of large quantities of magnetic or carbonaceous materials. It can be also ideal for custom-designed configurations of hybrid composites containing first and second transition metal oxides.

Target customer

This service is designed to supply nanoparticles for biomedical applications, including diagnosis and sensing. Research groups interested in generating large quantities for in vivo experiments, nanotoxicology or energy related applications are ideal customers.

Additional information

Selected References:

  1. A. Madrid, G. Martinez, F. Hornos, J. Bonet-Aleta, E. Calvo, A. Lozano, J.L. Hueso, Laser-induced tuning of carbon nanosensitizers to maximize nitrogen doping and reactive oxygen species production in the visible range, Catalysis Today, 422 (2023).
  2. G. Martinez, A. Malumbres, A. Lopez, R. Mallada, J.L. Hueso, J. Santamaria, Laser-Assisted Production of Carbon-Encapsulated Pt-Co Alloy Nanoparticles for Preferential Oxidation of Carbon Monoxide, Frontiers in Chemistry, 6 (2018).
  3. G. Martinez, A. Malumbres, R. Mallada, J.L. Hueso, S. Irusta, O. Bomati-Miguel, J. Santamaria, Use of a polyol liquid collection medium to obtain ultrasmall magnetic nanoparticles by laser pyrolysis, Nanotechnology, 23 (2012).

Selected Research Projects:

  1. Laser Pyrolysis For The Development Of Inorganic Nanoparticles –10/2017 – 09/2018. Funding Entity: TEIJIN LIMITED. PI: Jesús Santamaría
  2. PID2020-114926RB-I00: Generación asistida por láser de catalizadores de átomos aislados. Aplicaciones en energía, medio ambiente y salud. 09/2021 – 08/2024. Funding Entity: AGENCIA ESTATAL DE INVESTIGACIÓN PI: Jesús Santamaría

U09_JF_4522

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