Modification of oligonucleotides during and post synthesis to meet user requirements: Conjugation of oligonucleotides with fluorophores (fluoresceine, Cy3, Ct5, etc..) and other types of small molecules such as biotine, lipids. Conjugation to peptides. Phosphorothioate linkages Modified backbones such as locked nucleic acids (LNA), 2’-O-alkyl-RNA, etc.. Modified nucleobases: 2-aminopurine, 5-methyl-dC, etc… 5’, 3’-modifications such as 5’-, 3’-amino, 5’-, 3’-thiol, etc..
Modification of oligonucleotides during and post synthesis to meet user requirements:
Synthesis of oligonucleotides at various different scales (100 microg to 5 mg) and purification using HPLC and/or desalting.
