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U29. Oligonucleotide Synthesis Platform (OSP)

U29-S02. Modification of oligonucleotides. (Remote) OUTSTANDING

Modification of oligonucleotides during and post synthesis to meet user requirements:

  • Conjugation of oligonucleotides with fluorophores (fluoresceine, Cy3, Ct5, etc..) and other types of small molecules such as biotine, lipids.
  • Conjugation to peptides.
  • Phosphorothioate linkages
  • Modified backbones such as locked nucleic acids (LNA), 2’-O-alkyl-RNA, etc..
  • Modified nucleobases: 2-aminopurine, 5-methyl-dC, etc…
  • 5’, 3’-modifications such as 5’-, 3’-amino, 5’-, 3’-thiol, etc..

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U29-S03. Special nucleotides for oligonucleotide synthesis. (Remote) OUTSTANDING

Special nucleotides for oligonucleotide synthesis

For those services identified as outstanding, at least 20% of their capacity is open under competitive access. See Annex 1 of ACCESS PROTOCOL (provided by Nanbiosis) for details on % of openness for each service

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U29-E06. UV-Visible and luminometer Reader, multidetection system.

UV-Visible and luminometer Reader used in luciferase and MTT assays

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U29-E07. Electrophoresis apparatus with several vertical and horizontal cuvettes.

Electrophoresis apparatus with several vertical and horizontal cuvettes for agarose and polyacrylamide (PAGE) gel electrophoresis.

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U29-E01. Automatic synthesizer.

Automatic synthesizer which can be operated at a range of scales (40, 200, 1000 nanomols). A large variety of monomers can be incorporated using the phosphoramidite methodology such as natural and modified DNA, RNA monomers as well as fluorophores and other modifications.

U29-E01. Automatic synthesizer
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U29-E02. High-performance liquid chromatography (HPLC) systems with a diode array detector

Analytical and preparative high-performance liquid chromatography (HPLC) system with a diode array detector.

U29-E02. High-performance liquid chromatography (HPLC) systems with a diode array detector.
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U29-E03. Speed-Vac evaporators

Speed-Vac evaporators for removal of water in oligonucleotide samples

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U29-E04. UV spectrophotometer equipped with a Peltier temperature gradient.

UV-Visible spectrophotometer equipped with a Peltier temperature gradient to run thermal denaturation assays followed by UV absorption.

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U29-E05. Spectrofluorimeter equipped with a Peltier temperature gradient.

Spectrofluorimeter equipped with a Peltier temperature gradient to run thermal denaturation assays and characterization of DNA-binding drugs followed by fluorescence.

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U29-S01. Synthesis of oligonucleotides and characterization (On-site & Remote). OUTSTANDING

Synthesis of oligonucleotides at various different scales (100 microg to 5 mg) and purification using HPLC and/or desalting.

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