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Posts Taged coronavirus

NANBIOSIS U27 researchers working in an App for the early diagnosis of covid-19 through mobile phones

Bsicos group researchers, from the I3A (Engineering Research Institute) of the University of Zaragoza and CIBER-BBN), Dr. Jesús Lázaro, Dr. Eduardo Gil, Dr. Raquel Bailón and Dr. Pablo Laguna, are working on a line of work for the search of solutions for the early diagnosis of Covid-19 cases, through the development of an App for mobile phones.

For almost three years, Dr. Jesús Lázaro, under the supervision of Professor Pablo Laguna, from the resarch group Bsicos, which coordinate Nanbiosis U27 High Performance Computing , have been working on the European project WECARMON (Wearable Cardiorespiratory Monitor) for the development of an ambulatory system that would allow monitoring the cardiac and respiratory rhythm of patients with Clinical Obstructive Pulmonary Disease (COPD) and thus control and predict episodes of worsening of the disease.

However, the current situation of pandemic due to the SARS-CoV-2 coronavirus has led the researchers, with the approval of the European Commission, to temporarily redirect their objective, foccusing their work in search of solutions for the early diagnosis of the covid-19.
 
The work carried out for patients with a respiratory disease such as COPD could now serve for the early detection of people with symptoms of covid-19, before even having fever, but also for asymptomatic people, since the rapid variation of these parameters is known. in the initial stages of other respiratory conditions. Our researchers will use these cardiac and respiratory parameters, indirect markers of the autonomic nervous system and, therefore, sensitive to the response of the immune system, potentially helping to identify possible cases of covid-19 earlier. A technological tool that could join the fight to control this pandemic.

Jesús Lázaro has recently made a two-year stay at Connecticut University in the United States, partner of the WECARMON project in which he was working with Pablo Laguna. Two other researchers from the Bsicos group, Dr. Raquel Bailón and Dr. Eduardo Gil, have also decided to redirect their lines of research and focus on the SARS-CoV-2 coronavirus. Re-directing research lines with different objectives to join the fight against the coronavirus is a great challenge and shows the relenvance of cutting-edge research to provide answers to the arising challenges in our society.
 
Jesús Lázaro explains that the application they are working on would allow a pre-selection of people at risk by analysing markers of the autonomic nervous system that would be measured on a mobile phone. ” At this moment, the above-mentioned four researchers have already developed the algorithms for other platforms and they are working now on an App using the technology of the cameras and the flashlight of the mobiles. A sudden change in heart rate variability or an increase in respiratory rate could give a sensitive and early warning, to resort to other more specific diagnostic tests for covid-19, decreasing the latency time, which has been sadly shown key in this pandemic. The developments and validation, those already made and those planned, are being carried out using NANBIOSIS U27 High Performance Computing (I3A-Unizar/ CIBER-BBN)

The WECARMON project is funded by the H2020 Research and Innovation Program of the European Commission. It is part of the Marie Sklodowska-Curie Individual Actions, whose objective is to promote the professional career of young and brilliant researchers, expanding their knowledge through training, stays abroad and internships, in order to help them develop all their potential as researchers.

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Laura Lechuga talks about CONVAT, the project for a faster and cheaper diagnose of COVID-19

Prof. Laura M. Lechuga, Scientific Director of NANBIOSIS Unit 4 Biodeposition and Biodetection Unit (from CIBER-BBN and ICN2-CSCIC) has been today interview by Cadena Ser Radio in the program “Hoy por Hoy”

The interview can be listened in the following podcast, begining at 44 minute.

‘Convat’ is a nanotechnological device with biosensors capable of determining in less than half an hour the presence of coronavirus in a person. A sample saliva is deposited on a nanochip three centimeters long. If the saliva contains the virus, it will bind to antibodies located on the nanochip. A beam of light will be passed through the device so that the light will change if it encounters the virus and antibody in its path. The light will be analyzed automatically and the result will be transmitted to a smartphone or tablet. In less than 30 minutes a positive or negative result would be obtained and, in case of detecting the presence of the virus, in another 30 minutes at most the reconfirmation would be obtained. It is not intended for domestic use, but neither will a specialist technician be needed and it could be carried out in a massive way.

Simpler, cheaper and easier than current methods, this rapid diagnostic kit will not be ready for the first wave of the coronavirus, but it can be useful to detect it later if this virus is here to stay.

Yesterday, Laura Lechuga was also invited to explain the CONVAT project to the spanish television programe “A partir de hoy“.

‘Convat’, la prueba que puede detectar el coronavirus

https://twitter.com/FAQSTV3/status/1238968335192162306

Prof Laura Lechuga was also interviwed by TV3 in the program Planta Baixa 

More information here

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COVID-19 diagnose, faster and cheaper.

In order speed up research into the coronavirus, the European Commission recently announced a special call for projects to tackle the COVID-19, based on already developed technologies. Projectcs were prepared in a record time and 17 proposals have been awarded founds, 6 of them with spanish colaboration and only one coordinated by Spain

CONVAT is a cooperation project between Spain, Italy and France coordinated by Prof. Laura M. Lechuga, Scientific Director of NANBIOSIS Unit 4 Biodeposition and Biodetection Unit (from CIBER-BBN and ICN2-CSCIC) and also participated by the group of Prof. Jordi Serra Cobo from the University of Barcelona, having extensive experience in the study of coronavirus in animals and its epidemiology; Prof. Remi Charrel‘s laboratory at the University of Marseille (France), leader in virology and molecular biology, pioneering the development and production of biological material for the validation of new diagnostic systems and the Italian National Institute of Infectious Diseases (INMI), where researchers from Dr Antonino Di Caro‘s laboratory were among the first to sequence the SARS-CoV-2 coronavirus, and which is the reference institute for the analysis and diagnosis of COVID-19

CONVAT will develop a point-of-care platform, for rapid diagnosis and monitoring of coronavirus, directly from the patient’s sample and without the need for testing in centralized clinical laboratories. The new device based on optical biosensor nanotechnology is espected to become massively available in less than 12 months. The project indeed aims to extend beyond the current pandemic and the human diagnosis. The new biosensor will also be used for the analysis of different types of coronavirus present in reservoir animals, such as bats, in order to observe and monitor possible evolutions of these viruses and prevent future outbreaks in humans

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