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Posts Taged nano-emulsion-templating

Design of parenteral MNP-loaded PLGA nanoparticles by a low-energy emulsification approach as theragnostic platforms for intravenous or intratumoral administration

Encapsulation of magnetic nanoparticles (MNP) into PLGA nanoparticles has been achieved by nano-emulsion templating using for the first time both, a low-energy emulsification method as well as biocompatible components accepted for pharmaceuticals intended for human use. The incorporation of MNP by nano-emulsion templating method proposed in this work has been investigated in two different systems applying mild process conditions and is shown to be simple and versatile, providing stable MNP-loaded PLGA nanoparticles with tunable size and MNP concentration. MNP-loaded PLGA nanoparticles showed sizes below 200 nm by DLS and 50 nm by TEM, and mean MNP loading per PLGA nanoparticle of 1 to 4, depending on the nanoparticle dispersion composition. Physical-chemical features suggest that the MNP-loaded PLGA nanoparticles obtained are good candidates for intravenous or intratumoral administration.

The equipment of Dynamic Light Scattering (Dynamic Light Scattering) of NANBIOSIS Unit 12 has been used to determine the size distribution of polymer particles and Microscopy with Hyperspectral Analysis (Hyperspectral enhanced dark field microscopy) to detect the encapsulation of magnetic nanoparticles in polymer particles.

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Graphical abstract: Schematic representation of the preparation process of Fe3O4 MHighlightsN P-loaded PLGA nanoparticles by nano-emulsion templating.

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A new versatile methodology to produce polymeric nanoparticles loaded with gold nanoparticles

Conxita Solans, Scientific Director of Unit 12 of NANBIOSIS together with researchers of her group, Colloidal and Interfacial Chemistry of CIBER-BBN and IQAC-CSIC and the Department of Pharmacy and Pharmaceutical Technology, University of BarcelonaIn have published the research paper “Versatile Methodology to Encapsulate Gold Nanoparticles in PLGA Nanoparticles Obtained by Nano-Emulsion Templating” in the journal Pharmaceutical Research. The scientists have shown that a novel and very versatile methodology has been developed for the production of polymeric nanoparticles loaded with gold nanoparticles.

In this work, gold-nanoparticles (AuNP) have been encapsulated in polymeric nanoparticles using a novel and versatile methodology based on nano-emulsion templating, which has allowed to encapsulate high concentrations of gold nanoparticles (> 100 pM).  Polymeric nanoparticles loaded with AuNP with sizes lower than 100 nm have been obtained using this methodology. In addition, a safe and easy methodology for the phase transfer of gold nanoparticles from aqueous to organic solvents has been developed. The biocompatibility of the designed nanoparticles with both cultured cells and erythrocytes has confirmed their suitability to be intravenously administered Therefore, these nanoparticles represent novel advanced imaging systems for biomedical applications.

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