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U1. Protein Production Platform Unit (PPP)

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U1. Protein Production Platform (PPP)

U1. PPP logo IBB UAB
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The PPP Unit is at the Institute of Biotechnology and biomedicine of the Autonomous University of Barcelona (IBB-UAB) and counts with the necessary facilities for the design, production and purification of recombinant proteins. This facility is coordinated by the Nanobiotechnology Group, leaded by Prof. Antonio Villaverde. It has both highly specialized personnel and the necessary equipment to offer an “tailored” service for the design, production and purification of recombinant proteins using both prokaryotic and eukaryotic expression systems. Its location allows this service to be linked with other complementary services available within the university (Cell Culture, Cytometry, Production of Antibodies, Microscopy, Proteomic, and Bioinformatic,X-ray crystallography, and the Microarray and Sequencing Services), as well as facilitating the management of subsequent uses of the produced protein.

Counts with a laboratory perfectly equipped for the bioproduction of proteins, other with all the necessary equipment for the molecular cloning, plus one lab for the purification and characterization, and finally one for cryopreservation.

The PPP Unit is also applying for the ISO9001 certification forstandard quality control system.

News U1

07 Jun

NANOLIGENT, the first drug designed to eliminate metastases stem cells

NANBIOSIS researchers have developed a nanomedicine for the treatment of metastases by the selective elimination of tumor stem cells. It is a system based on nanoparticles that transport a chemotherapeutic drug and release it into cancer cells. The research team, led by Esther Vázquez and Antonio Villaverde, Strategy Director of NANBIOSIS U1. Protein Production Platform (PPP), in the IBB-UAB, and Ramon Mangues, Scientific Director of NANBIOSIS U18. Nanotoxicology Unit, in the Sant Pau Hospital, have already created a prototype of the drug and have conducted in vivo trials in animal models of colorectal cancer. They have demonstrated their effectiveness, selectiv[...]

25 May

Prof. A. Villaverde interviewed by CIBER-BBN Bulletin

Prof. Antoni Villaverde, Strategy Director of NANBIOSIS U1. Protein Production Platform (PPP), in an interview for the CIBER-BBN Bulletin, speaks about his research group, coordinanting NANBIOSIS u1 and the benefits of belonging to a research structure like CIBER. “The PPP – explains Prof. Villaverde – was generated within the group, but is currently a platform that has been gaining its own entity and structure, and has received the ISO certification granted by AENOR. Neus Ferrer-Miralles is the Scientific Director and Paolo Saccardo the technical coordinator. The objective of the activity developed by the PPP is based on supporting CIBER groups in the production and[...]

11 May

Fabry disease awareness month, April

The Fabry International Network (FIN) association established the month of April as the “month of Fabry” to raise awareness and educate about this disease, a rare, progressive and with multi-organ involvement pathology. Fabry Disease is one of several dozen Lysosomal Storage Disorders that interfere with the body’s ability to break down specific fatty substances. It is a rare disease and because the rate of occurrence is less than 1 in 200,000, it is considered as one of the many “Orphan” diseases. It is more common in women, but it occurs with greater severity in men. Fabry disease is a metabolic[...]

26 Apr

Designing nanomedicines

Next May 3, will take place in Barcelona, at the Academy of Medical and Health Sciences of Catalonia and the Balearic Island, an informative session and debate about Nanotecnology and Health “Designing Nanomedicines” in wich Prof. Antonio Villaverde, Strategy Director of NANBIOSIS U1. Protein Production Platform (PPP) will give a talk on “Nanobiotechnological approaches to cancer medicine“. Prof. Jesús Martínez de la Fuente, (ICMAB-CSIC / Universidad de Zaragoza – CIBER-BBN) will speak about “the nanorevolution: towards a healthier world“. The organization of the even has been in charge of Pilar Marco, Scientific Director of NANBIOSIS U2  Custom Antibody Service (CAbS), as a member[...]

25 Apr

Communication in science and transfer with Professor Antoni Villaverde

On June 6th, Aula Científica, in collaboration with IBB, organizes a theoretical and practical course on “Principles and practice of communication in science and in transfer“. Professor Antoni Villaverde, Strategy Director of NANBIOSIS U1. Protein Production Platform (PPP), will transmit his knowledge and experience on the preparation of scientific articles. The objectives of the course, aimed at researchers, entrepreneurs, teachers and managers of research and transfer, are to offer basic conceptual and instrumental tools in scientific communication, focused on the writing of scientific manuscripts, preparation of scientific and technological innovation projects and transfer , and in oral and corporal expression during[...]

28 Feb

“Smart-4-Fabry”: European project focused on the Fabry rare disease, participated by 4 units of NANBIOSIS

Smart-4-Fabry is a project coordinated by CIBER-BBN, funded by the European Commission within the Horizon 2020 Research and Innovation program with € 5.8 M for 4 years, which aims to develop a new nanomedicine for the treatment of the Fabry rare disease.   Fabry disease is a rare disease belonging to the group of lysosomal storage disorders, with a global incidence of 1:5,000 – 1:10,000, representing a priority health problem at European level.   The European project “Smart-4-Fabry”, is coordinated by CIBER-BBN, specifically by NANOMOL group at ICMAB-CSIC (Dr. Nora Ventosa) and the Biomaterial Processing and Nanostructuring Unit (U6) of  ICTS “NANBIOSIS”, and it[...]

11 Jan

Improving biomaterials imaging for nanotechnology: rapid methods for protein localization at ultrastructural level

New publication of Tony Villaverde, Scientific Director of Unit 1 of NANBIOSIS acepted by Biotechnology Journal: The preparation of biological samples for electron microscopy is material- and time-consuming because it is often based on long protocols that also may produce artifacts. Protein labeling for transmission electron microscopy (TEM) is such an example, taking several days. However, for protein-based nanotechnology, high resolution imaging techniques are unique and crucial tools for studying the spatial distribution of these molecules, either alone or as components of biomaterials. In this paper, we tested 2 new short methods of immunolocalization for TEM, and compared them with a[...]

20 Nov

Intracellular trafficking of a dynein-based nanoparticle designed for gene delivery

Unit 1 of NANBIOSIS, Protein Production Platform (PPP) and the  Nanobiotechnology research group of CIBER-BBN in collaboration with the Universidade Estadual de Campinas and the Universidade de São Paulo have recently published, in the European Journal of Pharmaceutical Sciences, the results of the research devoted to the improvement of protein-only based nanoconjugates for gene therapy. The evaluated gene-therapy vehicle prototype  displayed a similar transfection efficiency to that of the commercial vector LipofectamineTM 2000. Article of reference: https://doi.org/10.1016/j.ejps.2017.11.002[...]

U1-Protein Production Platform - PPP
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U27. High Performance Computing

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U27. High Performance Computing

  • Scientific Director: Prof. Pablo Laguna laguna@unizar.es
  • Scientific Coordinator: Alfonso Marquina amarq@unizar.es
  • Entities: I3A-Universidad de Zaragoza.
  • Address: C/Mariano Esquillor s/n 50018, Zaragoza
  • Phone: +34 976 76 27 07
  • Web: I3A-UZ

Nanabiosis-logo Universidad de Zarargoza-U9-U13-U27.

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Located at the Aragon Institute of Engineering Research (I3A), an Interdisciplinary University Research Institute specialized in engineering of the University of Zaragoza, this HPC service counts with a conditioned room to host a cluster of computers that allows remote access for High Performance Computing, massive storage and different software applications for the research in four divisions: Biomedical Engineering, Information and Communications Technologies Division, Processes and Recycling Division and Industrial Technology Division. This Unit is coordinated by Prof. Pablo Laguna, PI of the Biomedical Signal Interpretation & Computational Simulation Groups (BSICoS).

News U27

09 Jun

SINO-SPAIN Biomedical and Pharmaceutical Conference with NANBIOSIS participation

Last 7 June 2018 took place in Zaragoza, the Sino-Spain Biomedical and Pharmaceutical Conference, as a result of years of cooperation with Chinese institutions, organizad by Zaragoza University  and Aragonese Foundation for Research & Development of Aragon Government (ARAID), to promote initiatives and foster bilateral collaboration in biomedical and pharmaceutical sectors between Spain and China. The themes of the forum were: Molecular engineering for biomedical products Diagnoses &Design for new devices for medical uses Tissue Engineering and regenerative medicine Pharmacology and nanometerials for medical application Advanced therapies for cancer research   Researcher of three units of NANBIOSIS partcipated in the Conference: from U13. Tissue &am[...]

18 May

NANBIOSIS collaborates in the dissemination of science and triumphs in the Pint of Science Festival

On May 16, scientists from two units of NANBIOSIS filled the pubs, not to talk about football but about science. According to Jorge Bueno, Coordinator of Pint of Science in Spain, at the Vanguard “Science is also culture, just as we go to the bar to talk about football or politics, we can also talk about science, we want people to conceive science as part of society ” In the cafe of the civic center of the Casa Orlandai in Barcelona, ​​Eli Prats, a researcher of NANBIOSIS U8. Micro – Nano Technology Unit, explains her group has  developed graphene electrodes, a[...]

15 May

Nanotechnology, gene therapy, omics therapies and ‘big data’

Nanotechnology, gene therapy, omics therapies and ‘big data’ were the topics discussed in the Forum on Emerging Technologies oganized on May 8 by nanotechnology, gene therapy, omics therapies and ‘big data’ were the topics discussed in the I Forum on Emerging Technologies held on May 8, organized by the CIBER Internationalization Platform, of which the CIBERER, the CIBER-BBN and the CIBERES. The objective of this event, structured in sessions of presentations and scientific debates about the types of technologies addressed, was to promote the exchange of ideas and scientific knowledge with the aim of generating new collaborations among the CIBER researc[...]

10 May

Esther Pueyo will explain her research on the aging of the Heart in Pint of Science: The festival that brings science to pubs

The researcher of Unit 27 of NANBIOIS, High Performance Computing, will leave her laboratory and her office at the University to get on stage and take on the challenge of talking about her work to a public less used to scientific and technological language in the framework of a dissemination program of science to which Esther has joined as Pablo Laguna, Scientific Director of Unit 27 of NANBIOSIS, did last year. Esther will perform at the Drinks and Pool Aranda bar in Zaragoza (calle Conde de Aranda, 138) to tell her work in technology applied to health. It will be on Wednesday, the 16t[...]

30 Apr

I Forum on Emerging Technologies organized by CIBER

On May 8th, will take place in Madrid, at the Assembly Hall Ernest Lluch of the Instituto de Salud Carlos III, organized by CIBER Internationalization Platform (CIBER-BBN, CIBERER, CIBERES) the I Forum on Emerging Technologies. The objective of this meeting is to promote the exchange of ideas and scientific knowledge among the CIBER research groups with the aim of generating new collaborations for participation in cross-cutting projects and the development of border technologies. The content of the forum, centered on the type of technology and possibilities it offers, is structured in a program of lectures and scientific debates whose final objective is t[...]

08 Mar

Esther Pueyo closes the series of conferences “Mathematics in our life”

Next Tuesday, March 13, at 7:00 pm, in the facilities of the Social Work of Ibercaja of Patio de la Infanta, the third and last conference of the cycle “Mathematics in our life” will take place, organized by the Royal Academy of Sciences of Zaragoza (RACZ). With the title Mathematics and heart, a tandem with a great future, the last conference will be taught by Esther Pueyo Paules, professor at the University of Zaragoza, researcher at the BSICoS group of CIBER-BBN and I3A of the University of Zaragoza,which coordinates Unit 27 of NANBIOSIS High Performance Computer. Esther Pueyo is winner of a “Starting[...]

07 Mar

Numerical models applied to the cornea to improve eye surgery

Researchers of the NANBIOSIS U13 apply numerical models to the cornea to better understand how it behaves and help in surgical planning. Data and algorithms developed through the computer, together with the 3D image, make it easier for ophthalmologists to perform eye surgery more precise and personalized treatments for each patient The work carried out by Miguel Ángel Ariza Gracia at the Aragón Engineering Research Institute (I3A) has been recognized by the University of Zaragoza with the Extraordinary Award for the Best Doctoral Thesis of the Biomedical Engineering Program in 2017 In this line of research, framed in the European[...]

30 Nov

Pablo Laguna New Elevated IEEE Fellow for his contributions to cardiac biomedical signal processing

Pablo Laguna, Scientific Director of NANBIOSIS Unit 27, has recently been appointed as a select member (IEEE fellow) of the Institute of Electrical and Electronics Engineers within the society of Medical Engineering and Biology -IEEE-EMBS-. The grade of Fellow recognizes unusual distinction in the profession and is conferred only by invitation of the IEEE Board of Directors upon a person with an extraordinary record of accomplishments in any of IEEE’s designated fields of interest, in this case, Dr. Laguna is recognized for his contributions to cardiac biomedical signal processing. The IEEE-EMBSis the world’s largest international society of biomedical engineers. The 11,000 members of[...]

U27- High Performance Computing
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