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Ignacio García and Javier Bonet present their work on the CADENCE project in a one-minute video

Ignacio García and Javier Bonet, researchers from the Nanoporous Films and Particles (NFP) group and Nanbiosis U9 Synthesis of Nanoparticles Unit of the CIBER-BBN and the Institute of Nanoscience and Materials Science at the University of Zaragoza have presented their work on the CADENCE project in a video of a minute of duration that has been submitted to the #QueSigalaCiencia scientific dissemination contest promoted by the CIBER-BBN.

#QueSigaLaCiencia is a campaign on social networks that wants to explain to society, from an optimistic perspective, the importance of research and the work carried out by the research staff of the CIBER. The call -associated with the campaign- has had a high participation of the groups, who have presented 69 videos from all the scientific areas of the center. Researchers took on the challenge of telling their research in one minute. The works presented in the #QueSigaLaCiencia call have the possibility of opting for the prize that the public will give through Twitter (highest number of likes).

Their research work in the project CADENCE consists of designing and manufacturing nanopharmaceuticals that will fight cancer, not only in a more effective way, but also in a more selective way , avoiding damaging healthy cells. “By striking the tumor with light, which, for example, comes from a laser, the particles created by these researchers are capable of creating toxic substances for the cancer cell and, in addition, eliminating essential nutrients for the tumor to continue its growth ·.

The work carried out in NANBIOSIS is recognized by these researchers as “fundamental to continue innovating, advancing and providing solutions to different problems”.

CADENCE is a European Project (Catalytic Dual-Function Devices Against Cancer) that aims for a breakthrough in cancer therapy by developing a new therapeutic concept. The central hypothesis is that a growing tumor can be treated as a special type of reactor in which reaction conditions can be tailored to achieve two objectives: i) molecules essential to tumor growth are locally depleted and ii) toxic, short-lived products are generated in situ

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J. Santamaría, U9 NANBIOSIS gets 2.5M € to develop a revolutionary cancer treatment

Jesús Santamaría, Scientific Director of Unit 9 of NANBIOSIS, has obtained, for the second time in six years, an ERC Advanced Grant, one of the most prestigious and extremely competitive European research grants, restricted to senior researchers with a research trajectory of high quality for more than ten years.

The CADENCE (Catalytic Dual-Function Devices Against Cancer) project will be financed by the EU with 2.5M € to work for five years with a powerful team: four own researchers and seven others to be selected from candidates from all over the world.

With this project the researchers propose a revolutionary cancer treatment to be developed and tested. “The central idea of ​​the project is to consider the tumor as a chemical reactor in which catalysts can be introduced. A catalyst is agent  capable of directing chemical reactions and, in this case, would destroy molecules that are useful for the tumor and generate toxic products inside the tumor. The project thus has the potential to add a new member -catalysis- to the toolbox in oncology And if we could do within the tumor cells themselves we would have a very powerful tool. It would be to use catalysis as an arsenal in oncology “,  explained Jesús Santamaría.  But in addition to developing catalysts that can work successfully under intratumoral conditions (temperature, oxygen concentration, pH), a method must be devised to bring those catalysts selectively into the tumor either through the capillaries by which it extends or Or inside mesenchymal stem cells, as a Trojan horse. Finally, the project contemplates activating the catalysts remotely by infrared radiation, once they have achieved their goal. There are already initial results of the group that allow to glimpse possibilities of achieving these three objectives. A central part of the project will be the synthesis of catalytic nanomaterials. For this, the capabilities of NANBIOSIS-ICTS will be intensely used

Jesús Santamaría, believes that CADENCE has been selected because it is a new idea and, a priori, could be used in all types of tumors. “It’s new, it’s interesting and we’re going to contract the best researchers, because we’re going to need them,” he said. Among others, they will need experts in oncology, in photocatalysis and in modulation of bioreactors.  .

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