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Posts Taged quorum-sensing

The importance of bacterial Quorum Sensing (QS) research recognised in the Princesa of Asturias Awards

Today, Bonnie Bassler, Jeffrey Gordon, and Peter Greenberg are receiving the Princess of Asturias Award for their contribution to the knowledge of the role of the human microbiome and the bacteria Quorum Sensing.

Targeting Quorum Sensing allows understanding of bacteria behaviour and pathogenesis, but also developing new therapeutic and diagnostic strategies for infectious diseases.

Bonnie Bassler has shown how small chemical signals are involved in such a communication process.

Peter Greenberg was one of the first scientists who assigned the term Quorum Sensing (QS) to such a sophisticated system used by bacteria to communicate and synchronize behavior. He was involved on the discovery of the QS signalling pathways of important pathogens such as Pseudomonas aeruginosa and their implication on virulence and biofilm formation, key for the establishment of chronic and antibiotic-resistant infections

Jeffrey Gordon is a pioneer of microbiome research. These billions of bacteria living in our bodies have an extraordinary effect on our health, determining metabolic or even neurological disorders. His discoveries are tackling global issues such as childhood malnutrition.

The winners explained at the press conference the importance of this award:

“I couldn’t imagine that was going to be awarded the “Premio Princesa de Asturias” when I see those who have achieved it… they are icons, they are my idols in all kinds of fields!”, said Bonnie Bassler. Peter Greenberg explained that it is not only a recognition of the work done over many years in their research group but also of the work done by all the scientists in microbiology “This honor that has been granted to us is a recognition of how important microbiology and science in general is”.

From NANBIOSIS ICTS we want to congratulate the winners and thank the Princess of Asturias Foundation for the recognition of a piece of research which is of specific interest in our  Unit 2-CAbS, research group Nb4D – from CIBER-BBN and IQAC-CSIC, led by M. Pilar Marco. Her research line is focused on the development of diagnostic and therapeutic strategies for infectious diseases targeting the aforementioned Quorum Sensing (QS) and based on antibody-funded technologies. The QS is a sophisticated cell communication system controlling a series of cellular processes involved in pathogenesis, based on the release and detection of small signaling molecules (QSsm).

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Rare diseases international day 2023: some NANBIOSIS contributions

Today is the international day of rare diseases, a day to raise awareness and instigate change for people living with a rare disease. From NANBIOSIS we want to sume to this celebration and higtligh our commitment to helping people with rare diseases through research.

Dr. Ibane Abasolo, Scientific Director of NANBIOSIS U20, was at the WORLDSymposia conference last week in Orlando (FL, USA), where the latest advances in preclinical study and clinic of lysosomal storage diseases were explained. There, she presented the results obtained in the Smart4Fabry project coordinated by the CIBER-BBN where nanoliposomes were developed for the treatment of Fabry disease. The work, entitled “Preclinical Validation of Nanoliposomes for ERT for Fabry disease”, was a result of the collaboration of the groups of Dr. Ventosa and Dr. Corchero, both from CIBER-BBN, and the participation of units U1, U3, U6, and U20 of the ICTS Nanbiosis.

In addition, today Dr. Abasolo participated in the Nano Rare Day session, organized by the NanoMedSpain platform and the Barcelona Bioengineering Institute (IBEC) at the Sant Joan de Deu Hospital in Barcelona, presented the work entitled “Use of natural and artificial nanoparticles for the treatment of lysosomal storage diseases”, where in addition to nanoliposomes, she also detailed how extracellular vesicles can be a good vehicle to improve replacement enzyme therapy in lysosomal diseases.

Also Dr. Juan Pablo Salvador from NANBIOSIS U2 CAbS has presented at in the Nano Rare Day session his talk on “Quorum Sensing to improve the management of cysticfibrosis“, explaining the difficulty of quickly identifying bacterial infections, which are common in patients with Cystic Fibrosis. In this sense, “Quorum Sensing”, a microbial communication mechanism through which the cells themselves regulate the expression of genes based on cell density, can help identify biomarkers and improve the management of cystic fibrosis.

Related news: Fabry Desease in the Rare Disease Day: A New Hope

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