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U26-S04. In vivo NMR of small animals (zebrafish, Drosophila)

In vivo NMR of small animals (zebrafish, Drosophila)

The service is intended for obtaining images of small animals such as zebrafish, Drosophila. Also longitudinal studies can be performed. Thanks to a 14 T nmr equipment equipped with a micro-image probe

Customer benefits

The service is integrated in the University of Valencia core facility that ensures the correct maintenance and the offsite service runed by technicians under ISO 9001.

Target customer

The primary audience are pre-clinic research groups that require punctual or longitudinal studies on such small animals with high resolutions.

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U20-S012. Inmunihistochemistry on histological samples (Remote) OUTSTANDING

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U20-S11. Histological porcessing, section and staining (Remote) OUTSTANDING

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U20-S010. Ultrasound imaging in vivo (Remote) OUTSTANDING

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U20-S09. X-ray imaging in vitro and in vivo (Remote) OUTSTANDING

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U13-S08. Atomic Force Microscopy indentation test

Atomic Force Microscopy indentation test

Atomic Force Microscopy can be used to measure the forces between the probe and the sample as a function of their mutual separation. This can be applied to perform force spectroscopy.

Customer benefits

Low forces on cells (nano-scale).

Target customer

Public and private research groups focused on mechanobiology

Additional information

Cantilever + cells
Force curve
Capsules
AFM Software
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U10-S9.

Characterization and development of pulmonar formulations

Encapsulation of therapeutic actives of interest in formulations for pulmonary administration with possibility of lyophilisation to obtain a powder. The service has two cutting-edge equipments for the characterization of pulmonary formulations:
SprayTec laser diffraction system: allows the measurement of spray particle and spray droplet size distributions in real-time for more efficient product development of sprays and aerosols, with robust and reproducible droplet size data.
Next Generation Impactor: has been designed specifically for the pharmaceutical industry for testing metered-dose inhalers, drypowder inhalers, nebulizers and nasal sprays. It consists of a high performance cascade impactor for classifying aerosol particles into micrometer size fractions, providing relevant information about their distribution in the respiratory tract.

Customer benefits

The formulations can be characterized, following SOPs, in terms of particle size, polydisperstity index and zeta potential. Importantly, this service can also offer real-time droplet size distribution and aerosol particles classification analysis by means of SprayTec and Next Generation Impactor (NGI) technology.

Target customer

  • Preclinical use for the characterization of the pulmonary formulation prior to its implementation in in vivo models.
  • Companies interested in characterizing their formulations or their pulmonary administration systems.

References

Moreno-Sastre M, Pastor M, Esquisabel A, Sans E, Viñas M, Fleischer A, Palomino E, Bachiller D, Pedraz JL. Pulmonary delivery of tobramycin-loaded nanostructured lipid carriers for Pseudomonas aeruginosa infections associated with cystic fibrosis. Int J Pharm. 2016 Feb 10;498(1-2):263-73. doi: 10.1016/j.ijpharm.2015.12.028.

Additional information

U10 Pulmonar formulations characterization.tif

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U10-S8.

3D bio-impression of scaffolding for regenerative medicine

The principle of 3D bioprinting consists of selecting the most suitable biomaterials and cell types to prepare a Bioink that should be able to promote cell growth and differentiation and present appropriate mechanical properties of the target tissue.
This service possess a wide variety of 3D bioprinting techniques avaliable, such as extrusion, droplet, electrospining, electrowritting and stereolithography.

Customer benefits

One of the main characteristics of this additive manufacturing technique is its ability to bioprint the desired layers, with specific cell orientation , and desired morphology of the bioprinted 3D scaffold in order to ressemble, as much as possible, the tissue of interest. To achieve this goal, rheology, texturometry, printability and biological assays are carried out.

On the one hand, this technology can be employed to develop 3D scaffolds specific for the regeneration of particular tissues. On the other hand, this strategy offers a 3D environment that mimics the tissue/ organ of interest in order to test potential therapeutic tools, which goes in accordance with the implementation of the 3R principle (replace, reduce and refine).

Target customer

  • Preclinical use for in vitro and in vivo models.
  • Pharmaceutical industry (e.g. cosmetics)

References

  • Lafuente-Merchan M, Ruiz-Alonso S, García-Villén F, Zabala A, de Retana AMO, Gallego I, Saenz-Del-Burgo L, Pedraz JL. 3D Bioprinted Hydroxyapatite or Graphene Oxide Containing Nanocellulose-Based Scaffolds for Bone Regeneration. Macromol Biosci. 2022 Nov;22(11):e2200236. doi: 10.1002/mabi.202200236.
  • Lafuente-Merchan M, Ruiz-Alonso S, Zabala A, Gálvez-Martín P, Marchal JA, Vázquez-Lasa B, Gallego I, Saenz-Del-Burgo L, Pedraz JL. Chondroitin and Dermatan Sulfate Bioinks for 3D Bioprinting and Cartilage Regeneration. Macromol Biosci. 2022 Mar;22(3):e2100435. doi: 10.1002/mabi.202100435.
  • Ruiz-Alonso S, Villate-Beitia I, Gallego I, Lafuente-Merchan M, Puras G, Saenz-Del-Burgo L, Pedraz JL. Current Insights Into 3D Bioprinting: An Advanced Approach for Eye Tissue Regeneration. Pharmaceutics. 2021 Feb 26;13(3):308. doi: 10.3390/pharmaceutics13030308.

Additional information

U10 Biorpinters.png 3D Bioprinters: BIO X 3D Bioprinter –CELLINK (left); R-GEN 100 –REGENHU (right).

https://www.nanbiosis.es/wp-content/uploads/2017/10/piel.jpg Bioprinted 3D scaffold

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U9-S06. Consultancy

Consultancy

The unit can provide advice about the most suitable synthesis method to obtain nanoparticles and/or the most convenient characterization techniques according to the customers´ needs

Customer benefits

The customer will benefit from the experience of the facility to help and guide in the selection of the most suitable synthesis approach depending on the customer´s needs.

Target customer

Material suppliers, pharma industry, research laboratories and research groups with interests in biomedicine, nanotoxicology, drug delivery, development of new materials for catalysis, encapsulation, delivery.

Related projects

  1. Laser Pyrolysis For The Development Of Inorganic Nanoparticles –10/2017 – 09/2018. Funding Entity: TEIJIN LIMITED.
  2. Desarrollo de fibras, polímeros y cerámicas con propiedades foto-catalíticas intrínsecas. 23/11/2021-23/11/2024. Funding Entity: NUREL, S.A.
  3. Investigación y desarrollo de nuevas metodologías de análisis estructural de papel reciclado y su aplicación a la optimización de papeles. 01/09/2021-31/08/2023. Funding Entity: S.A. INDUSTRIAS CELULOSA ARAGONESA
  4. Preparación Y Caracterización De Superficies Filtrantes Conteniendo Nanopartículas Basadas En Cu En Superficie 09/2020- 11/2020. Funding Entity: VISCOFAN, S.A. PI: Jesús Santamaría
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U8-S04. Graphene growth services (On-site&Remote) OUTSTANDING

Graphene growth services (On-site&Remote) OUTSTANDING

CVD graphene growth on copper foils and transfer of CVD graphene to rigid/flexible substrates.

Customer benefits

Adaptable platform for electrical characterization of microelectrodes to meet customer needs

Target customer

Research groups and SMEs

References

  • Masvidal-Codina E, Illa X et al., Nature Materials 18 (2019) 280-288
  • Bonaccini Calia et al., Nature Nanotechnology 17 (2022) 301-309
  • Brosel-Oliu et al. Small (2023) 2308857
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