News

“Minimal invasion, maximum innovation”

“Minimal invasion, maximum innovation” is a repot by Spanish TV about the Minimal Invasion Surgery Center, Jesús Usón, partner of NANBIOSIS.

“The unique capabilities of the Center from its animal farm to its surgical infrastructure allow the evaluation and validation of new technology such as medical devices, new biomaterials, new pharmacological therapies, before being used in human patients” explains Francisco Miguel Sanchez Margallo, Sciencitific Director of the Center and Deputy Scientific Director of NANBIOSIS- ICTS.

Verónica Crisóstomo, Scientific Director of NANBIOSIS Unit 24 of Medical imaging explains a current project that studies how to reduce the damage caused by a heart attack with stem cell-based treatment

The report can be seen heer:

http://www.rtve.es/m/alacarta/videos/lab24/lab24-reportaje-minima-invasion-maxima-innovacion/5425735/

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Best Poster award at the congress of Spanish Society of Nephrology

Researchers of Unit 17 of NANBIOSIS Confocal Microscopy Service and the GITBIT-UAH group (CIBER-BBN, Univerty of Alcalá de Henares), have been awarded with the PRIZE FOR THE BEST POSTER COMMUNICATION by the Spanish Society of Nephrology (S.E.N.) and Senefro Foundation.

“The ILK deletion prevents extravasation of monocytic line leukocytes induced by the accumulation of uremic toxins during chronic kidney disease” authored by CAMPILLO DE BLAS, L BOHORQUEZ MAGRO, D GARCÍA AYUSO, B GARCÍA CARRASCO, M GRIERA, S DE FRUTOS, M RODRÍGUEZ-PUYOL, D RODRÍGUEZ-PUYOL, L CALLEROS BASILIO.

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Formulation of emulsions: Science behind cosmetics at COSMETORIUM

Carlos Rodríguez-Abreu, Scientific Director of NANBIOSIS Unit 12 Nanostructured liquid characterization unit, from Institute of Advanced Chemistry of Catalonia, Higher Council for Scientific Research (IQAC-CSIC) and CIBER of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) has participated in the fourth edition of COSMETORIUM, given a talk on “Recent advances in the formulation of emulsions”

The fair of Cosmetorium, which was held at the Palau de Congresos de Barcelona on October 23 and 24, is organized by the Spanish Society of Cosmetic Chemists (SEQC), begun with keynote conferences and a scientific program, which examined the key problems facing the cosmetic and personal care industry, on issues such as global regulatory problems and science technology.

COSMETORIUM is a forum on creation, formulation, manufacture and distribution of cosmetic products, ranging from the development of the idea of a product until its arrival to consumers that highlighs the importance of Spain as a center of excellence in the cosmetic industry. In fact, Cosmetorium has joined the Formulating Cosmetics & Making Cosmetics series of events that have achieved great success in Italy and the United Kingdom, with over a thousand attendees.

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NANBIOSIS AT THE CIBER-BBN ANNUAL CONFERENCE 2019

On October 21 and 22, CIBER-BBN has celebrated its 13th Annual Conference in Tarragona, with a session dedicated to NANBIOSIS on the afternoon of Monday 21. The Singular Technical Scientific Infrastructure (ICTS) for the production and characterization of biomaterials, nanomaterials and devices up to its preclinical validation for the production and characterization of biomaterials, nanomaterials and devices up to its preclinical validation is integrated by of the CIBER-BBN, the Minimally Invasive Surgery Center Jesus Usón and Bionand after its incorporation to the ICTS last year. NANBIOSIS, presented its annual activity.

The Session was chaired by its Scientific Director, Jaume Veciana who also gave an Annual Summary, after that, the new unit 29 of NANBIOSIS, the Oligonucleotide Synthesis Platform, was presented by its Scientific Director Ramon Eritja Casadellà, from CIBER-BBN and Catalan Institute of Advanced Chemistry- CSIC . Finally, the Infrastructure for OMICS technologies (OmicsTech ICTS): metabolomics for clinical and nutritional research, was presented by Xavier Domingo-Almenara, Centre for Omics Sciences, EURECAT- Rovira i Virgili University.

After the NANBIOSIS Session, was the NANBIOSIS Scientificic Advisory Board meeting.

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Biomarkers in semen to diagnose prostate cancer

Sara Larriba of the Human Molecular Genetics Group of Bellvitge Biomedical Research Institute (IDIBELL) has informed NANBIOSIS about a recent publication mentioning NANBIOSIS in the Acknowledgements for its participation in the results of their research. (The nanoparticle tracking analysis was performed by the ICTS NANBIOSIS U6 Biomaterial Processing and Nanostructuring Unit) The article has been published by the journal Scientific Reports of Nature Research.

The prediction of PCa in the early stage of the disease is one of the most important objectives in male urology. A significant decrease in deaths due to PCa has been associated with the use of serum PSA test recent years. However, the PSA test still has serious limitations and often gives false positives that lead to many unnecessary biopsies of benign disease. Therefore, researchers from the Human Molecular Genetics Group of Bellvitge Biomedical Research Institute (IDIBELL) decided to evaluate semen as a source of prostate cancer biomarkers, and studying extracellular miRNAs, which are present within semen in extraordinary concentrations since some of the Some of these extracellular miRNAs are specific to the prostate gland and, in addition, there is already research showing that extracellular miRNAs can reflect altered patterns of miRNA expression in prostate tumor tissue. The study conducted allowed scientists to discover a distinctive miRNA expression pattern in exosomal semen samples obtained from men with prostate cancer compared with that found in exosomal semen samples taken from healthy men. The next step would be to conduct more prospective studies in larger patient cohorts before this miRNA-based biomarker can be adopted in daily clinical practice.

Article of reference:

Semen miRNAs Contained in Exosomes as Non-Invasive Biomarkers for Prostate Cancer Diagnosis, Maria Barceló, Manel Castells, Lluís Bassas, Francesc Vigués2 & Sara Larriba. Scientific Reports volume 9, 24 Sept 2019.

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Nanbiosis and CIBER-BBN present at BioNanoNet and Austrian Microfluidics Initiative (AMI)

Nanbiosis-ICTS and CIBER-BBN were present at BioNanoNet Annual Forum & Networking event and the Austrian Microfluidics Initiative (AMI) workshop “Biomedicine on Chip” that took place on 10-11th of September 2019 at the premises of the University of Salzburg attracting about 40 participants from both science and industry.

For furher information: https://www.bionanonet.at/; www.microfluidicsaustria.at

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Preclinical brain tumour therapy response assessment with MRSI approaches: Oral presentation awarded to Ana Paula Candiota

NANBIOSIS U25 scientific coordinator, Ana Paula Candiota, has recently presented a scientific work about preclinical brain tumour therapy response assessment with MRSI approaches in the 36th annual meeting of ESMRMB held in Rotterdam, Netherlands, October 3-5. Work was entitled “Oscillatory pattern of response in MRSI-based Glioblastoma therapy follow-up: an immune system biomarker?” and was awarded an oral presentation in the scientific session of Animal Models: Brain & others

Article of refrence:
L. Villamañan, P. Calero, S. Wu, N. Arias-Ramos, M. Pumarola, S. Ortega-Martorell, M. Julià-Sapé, C. Arús, A.P. Candiota. Oscillatory pattern of response in MRSI-based Glioblastoma therapy follow-up: an immune system biomarker? European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) 2019. Rotterdam, NL. Oct 2019.

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Not always what closes best opens better: mesoporous nanoparticles capped with organic gates

Researchers of NANBIOSIS Unit 26 NMR: Biomedical Applications II have recently published an article in the scientific journal Science and Technology of Advanced Materials,

Four types of calcined MCM-41 silica nanoparticles, loaded with dyes and capped with different gating ensembles are prepared and characterized. N1 and N2 nanoparticles are loaded with rhodamine 6G and capped with bulky poly(ethylene glycol) derivatives bearing ester groups (1 and 2). N3-N4 nanoparticles are loaded with sulforhodamine B and capped with self-immolative derivatives bearing ester moieties. In the absence of esterase enzyme negligible cargo release from N1, N3 and N4 nanoparticles is observed whereas a remarkable release for N2 is obtained most likely due to the formation of an irregular coating on the outer surface of the nanoparticles. In contrast, a marked delivery is found in N1, N3, and N4 in the presence of esterase enzyme. The delivery rate is related to the hydrophilic/hydrophobic character of the coating shell. The use of hydrophilic poly(ethylene glycol) derivatives as gating ensembles on N1 and N2 enables an easy access of esterase to the ester moieties with subsequent fast cargo release. On the other hand, the presence of a hydrophobic monolayer on N3 and N4 partially hinders esterase enzyme access to the ester groups and the rate of cargo release was decreased.

Aricle of reference:

Elena Añón, Ana M. Costero, Pablo Gaviña, Margarita Parra, Jamal El Haskouri, Pedro Amorós, Ramón Martínez-Máñez & Félix Sancenón (2019) Not always what closes best opens better: mesoporous nanoparticles capped with organic gates, Science and Technology of Advanced Materials, 20:1, 699-709, DOI: 10.1080/14686996.2019.1627173

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Biomedicine Project Manager job vacancy

CIBER-BBN is looking for proyect manager for a european project in biomedicine to coordinate NANBIOSIS units participation in the project.

The position requires good command of English and strong skills in coordinating researchers.

Applications must be filed at CIBER’s web portal untill October 15.

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CIBER-BBN Annual Conference 2019

In one month CIBER-BBN will celebrate its 13th Annual Conference on October 20 and 21 in Tarragona, at the Hotel Ciutat de Tarragona, Tarragona.

This year there several scientific sessions are planned about related leading issues with research topics of interest to CIBER-BBN. On Monday there will be three sessions centered in:

artificial intelligence and big data
gene editing and CRISPR and
liquid biopsy and point-ofcare.

Each of these sessions will include a plenary conference given by an expert
guest and two talks by BBN researchers, followed by an open debate.

The program will complete a session focused on the Singular Technical Scientific Infrastructure NANBIOSIS-ICTS.

On Tuesday, the four prizes will be awarded to the best scientific articles published by young researchers of CIBER-BBN during 2018 and there will be two other sessions on

nanobots and emerging drug administration technologies and
senescence and reprogramming

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