HR-MAS NMR is based on solid-state NMR, which uses magic-angle spinning at high speeds to average anisotropic interactions, leading to narrower widths. The moderate spin rates used in HR-MAS allows high resolution spectra to be obtained from intact tissue, i.e., without the need of any metabolite extraction procedure. HR-MAS NMR is widely used for metabolomic studies, especially in cancer research, where the metabolic profile (metaboloma) of tumor biopsies can be characterized using just few milligrams of intact tissue (tissue biopsy). HR-MAS can also be used for the structure characterization and elucidation of partially insoluble compounds.
>> Metabolomics of intact tissue samples (tumor biopsies, …)
>> Structure Characterization and Elucidation of partially insoluble compounds)