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U7-S04. Lytography by e-beam

Lytography by e-beam

An electron beam lithography service allows the fabrication of structures at the nanoscale. By using a combination of different type of electron-sensitive resists, a variety of surfaces with special interest in bioengineering can be processed locally, from metallic to insulators.

Customer benefits

Our electron beam lithography service allows our customers, to locally modify a surface at the nanoscale to study submicron systems.

Target customer

Our target customers are researchers in the field of bioengineering or R&D departments of biotech companies, which want to test models, perform proves of concept, prototypes, etc. at the submicron-scale.

Additional information

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U7-S03. Characterization by SEM

Characterization by SEM

The Scanning Electron Microscopy service of U7 is specialized in the high-resolution imaging of different samples in the bioengineering field. We can investigate surface morphology and topography of biological samples, polymeric structures and tissue, but also of semiconducting materials, inorganic heterostructures, etc. which are commonly related to biomedical devices and/or biomaterials. We provide advice in the preparation of the samples, as well as assistance in their characterization.

Customer benefits

Our SEM service benefits from being part of a bioengineering-specialized research centre, providing wide knowledge in the treatment and imaging of biological samples, devices and biomaterials. We offer custom services, assuring close and direct interaction with the client, to meet conclusive results and high-quality needs.

Target customer

Our target customers are researchers in the field of bioengineering or R&D departments of biotech companies which want to test, characterize, or compare different samples or prototypes.

Additional information

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U7-S01. Training Courses in the Use of microfabrication equipment

Training Courses in the Use of microfabrication equipment

The Training Courses in the Use of microfabrication equipment of U7, provides full knowledge in the theoretical and technical aspects of the techniques and equipment. We provide our clients the necessary know-how on the tools, to conduct their microfabrication processes on their own in an autonomous way, and the theoretical insights to design and optimize new processes and recipes.

Customer benefits

Our Training Courses in the Use of microfabrication equipment, benefits from being part of a bioengineering-specialized research centre, providing wide knowledge in the main applications and a large experience in the fabrication of biomedical devices in the field of bioengineering with different techniques and materials. We offer custom services, assuring close and direct interaction with the client, to meet conclusive results and high-quality needs.

Target customer

Our target customers are researchers in the field of bioengineering, or R&D departments of biotech companies which want to fabricate their custom biomedical prototypes or devices.

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U6-S11. Specific density of powders (On-site&Remote) OUTSTANDING

Specific density of powders

Volume and density measurement of porous solids and powders.
Fully automated gas pycnometer, for the measurement of volume and density of powders, granular materials, and solid objects. Typical applications include: porous materials such as catalysts and activated carbons, pharmaceuticals and excipients , foods (raw, refined and end products), ceramics and refractory materials, geological samples (soils, rocks, sediments), building materials (concrete, cement), polymers and composites.
The equipment for this purpose is Ultrapyc 1200e Helium Pycnometer (Quantachrome Instruments).

Customer benefits

The equipment provides density measurements of solids and powders for customers who need to characterise this property and add value to their materials.

Target customer

Universities, public research organisations and pharmacological and chemical industries.

Additional information

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U6-S12. Packed (tapped) density (On-site) OUTSTANDING

Packed (tapped) density

Each particle of a solid material has effectively the same true density regardless of size or shape, but more or less geometric space is occupied by the material according to the relative particle-particle cohesion and mechanical interference. That is, the apparent bulk densities of powdered, granular or flaked materials are highly dependent on the manner in which the particles are packed together. Furthermore, handling or vibration of particulate material causes the smaller particles to work their way into the spaces between the larger particles. The geometric space occupied by the powder decreases and its density increases; ultimately no further natural particle packing takes place without the addition of pressure and maximum particle packing is achieved.
The equipment for this purpose is Autotap (Quantachrome Instruments).

Customer benefits

The equipment provides tapped density measurements of powders for customers who need to characterise this property and add value to their materials.

Target customer

Universities, public research organisations and industries.

Additional information

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U6-S03. Design of experiments (DOE SOFTWARE)

Design of experiments (DOE SOFTWARE)

We offer a Software platform and assitance in performing Design of Experiments, a systematic and statistical approach to planning, conducting, and analyzing experiments or tests. It involves strategically manipulating variables to gather relevant and reliable information while minimizing resources and time.

Customer benefits

DOE helps researchers and engineers understand the relationships between factors, identify optimal conditions, and improve processes by optimizing performance and reducing variability.

Target customer

Manufacturing companies and research groups dealing with experimentation.

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U6-S04. Analysis of particle size, concentration and Z-potential of nanoparticles (On-site&Remote) OUTSTANDING

Analysis of particle size, concentration and Z-potential of nanoparticles

Measurement of the particle size distribution, Z-potential and concentration of solid or dispersed materials (suspensions, liposome, vesicles, emulsions).

The equipments for the analysis are the following:

  • Zetasizer Nano & Ultra (Malvern Panalytical)
  • Mastersizer 2000 (Malvern Panalytical)
  • Nanosight NS300 (Malvern Panalytical)

Customer benefits

The equipment provides particle size, concentration and Z-potential measurements for customers who need to characterise these physico-chemical properties and add value to their materials.

Target customer

Universities, hospitals, public research organisations and pharmacological and chemical industries.

References

  • Nanomedicine 2020 24:102136. 10.1016/j.nano.2019.102136.
  • ACS Appl. Mater. Interfaces 2020, 12, 18, 20253–20262 https://doi.org/10.1021/acsami.0c03040
  • Chem. Mater. 2022, 34, 19, 8517–8527 https://doi.org/10.1021/acs.chemmater.2c00384

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U6-S05. Freeze dryer

Freeze dryer

Freeze drying (also known as lyophilization) is a water (or other solvents) removal process typically used to preserve materials, with the goal of extending their shelf life or reducing its weight. Freeze drying works by freezing the material, then reducing the pressure and adding heat to allow the frozen water in the material to change directly to a vapor (sublimation).

Freeze drying occurs in three phases:

  1. Freezing: Freezing can be done in a freezer, a chilled bath (shell freezer) or on a shelf in the freeze dryer. Cooling the material below its triple point ensures that sublimation, rather than melting, will occur. This preserves its physical form.
  2. Primary Drying: Freeze drying’s second phase is primary drying (sublimation), in which the pressure is lowered and heat is added to the material in order for the water to sublimate. About 95% of the water in the material is removed in this phase. Primary drying can be a slow process.
  3. Secondary Drying: Freeze drying’s final phase is secondary drying (adsorption), during which the ionically-bound water molecules are removed. Most materials can be dried to 1-5% residual moisture.

Customer benefits

  • Solvent removal typically used to preserve materials, with the goal of extending their shelf life or reducing its weight.
  • The design of the equipment offers the best performance in the smallest possible space.
  • Equipment suitable for laboratories: compact and easy to install.
  • Technical reliability and excellent performance.
  • Ease of use: touch screen user interface.

Target customer

  • Pharmaceutical industry
  • Food Industry
  • Chemical industry
  • Materials research centers
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U6-S06. Pulse-free microfluidic system

Pulse-free microfluidic system

Our device offers a pulse-free miniaturized platform designed to manipulate and control small volumes of fluids at the microscale, ranging from microliters to picoliters. The compact size, reduced sample consumption, faster reaction times, and potential for automation make microfluidic devices advantageous for a wide range of scientific and biomedical purposes.

Customer benefits

Offers precise handling of fluids within microchannels or microstructures, enabling various applications such as chemical analysis, biological assays, drug delivery, and point-of-care diagnostics.

Target customer

  • Chemical and biochemical companies.
  • Biology and chemistry research groups.
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U6-S07. Interactions of two biomolecules with respect to binding kinetics and affinity by surface plasmon resonance (SPR).

Interactions of two biomolecules with respect to binding kinetics and affinity by surface plasmon resonance (SPR).

Technically speaking, SPR refers to an optical phenomenon that enables monitoring of changes in refractive index via a quantum mechanical principle.

In a traditional SPR experiment:

  • A target is immobilized or captured onto a surface known as a sensor chip.
  • A pump is used to flow analytes over the sensor chip.
  • An optical measurement system captures changes occurring on the surface of the sensor chip.
  • Software plots time-dependent responses in the form of a graph called a sensorgram.

Customer benefits

With SPR, you can determine the rates and affinity of interactions between biomolecules and answer multiple questions using a single instrument.
SPR is the gold standard for analyzing biomolecules, providing:
High quality kinetics (association and dissociation constants, plus equilibrium)

  • Real-time data acquisition.
  • Label-free analysis.
  • Faster, automated experiments.
  • Lower sample consumption.

SPR’s flexibility lets you study biomolecular interactions in a wide variety of analytes, from small molecules in drug discovery to peptides, proteins, DNA, viruses, and even whole cells. SPR allows for:

  • Simple yes/no binding
  • Equilibrium studies
  • Complex kinetic analyses
  • Thermodynamic analysis
  • Concentration determination

Target customer

  • Pharmaceutical industry
  • Food Industry
  • Chemical industry
  • Materials research centers

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