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Posts on Jan 1970

New equipment adquired to improve NANBIOSIS U20

NANBIOSIS, U20. In Vivo Experimental Platform, led by Dr. Ibane Ibasolo, has been updated and improved as a result of its participation in the project FICTS1420-20, selected by the MICINN for co-financing by the FEDER Program in ICTS 2014-2020 (Equipment for setting standardized immunotoxicology assays for the U20 -NANBIOSIS I17 Action of the Investment Plan-)

A particle particle analyzer equipment (Exoid) has been inslalled at NANBIOSIS U20 for measurement of the concentration and the size of nanoparticles. The Exoid is the latest instrument from the Izon company to measure the physical characteristics of nanoparticles in electrolytic solution. Based on Tunable Resistive Pulse Sensing (TRPS) principles, the equipment is capable of measuring the size of the particles, their concentration and Z potential, through the use of a nanopore that allows measurements to be made in a defined size range.

Finally, a new upright laboratory freezer Liebherr _ SFNe 5227 has been adquired for the storage of the samples and reagents used in the different services of FVPR/U20,

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The role of microfluidics and 3D-bioprinting in the future of exosome therapy. A high impact review

Researchers of the NanoBioCel research group of the University of the Basque Country (UPV/EHU) and CIBER BBN, belonging to NANBIOSIS U10 Drug Formulation, Bioaraba, and CONICET Foundation of Argentina, have collaborated in a studio entitled: “The role of microfluidics and 3D-bioprinting in the future of the exosome therapy” which has been published in the journal Trends in Biotechnology, whose editorial seeks particularly relevant articles.

The importance of this publication lies in the novelty and potential of nanovesicles as new therapeutic agents and the versatility of microfluidic technology in combination with 3D bioprinting to bring nanovesicles closer to the clinic.

Article of reference:

Mikele Amondarain, Idoia Gallego, Gustavo Puras, Laura Saenz-del-Burgo, Carlos Luzzani, José Luis Pedraz, “The role of microfluidics and 3D-bioprinting in the future of exosome therapy”, Trends in Biotechnology,
2023, ISSN 0167-7799

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Symposium Tribute to Prof. Pepe Becerra “40 years of the Bioengineering and Tissue Regeneration Laboratory (LABRET)”

Symposium on the occasion of the retirement of Prof. José Becerra Ratia: “40 years of the Bioengineering and Tissue Regeneration Laboratory (LABRET): tribute to Pepe Becerra”

We are pleased to inform about the Symposium organized by the LABRET group (Bioengineering and Tissue Regeneration Laboratory), University of Malaga, on the occasion of the retirement of Professor José Becerra.

The event will be held, only in person, on July 7 in the morning at the Faculty of Sciences of the University of Malaga

Download the program.

Prof. José Becerra was the Director of the Andalusian Center for Nanomedicine and Biotechnology (BIONAND) since February 2014, before the merger of Bionand and IBIMA (Biomedical Research Institute of Malaga) as IBIMA-Plataforma BIONAND. In fact, Prof, José Becerra took an important role in the incorporation of BIONAND into the ICTS NANBIOSIS till then integrated by Cento de Investigación Biomédica en Red (CIBER) in the area of Bioengineering, Biomaterial, and Centro de Cirugía de Mínima Invasión Jesús Usón, (CCMIJU) and he was also the first Director of the Unit 28 of NANBIOSIS.

In NANBIOSIS we want to show our gratitude to Prof. Becerra, with  appreciation and admiration for his contribution to strengthening this ICTS.

Related News:

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2023 Annual Conference of CIBER-BBN and NANBIOSIS

CIBER-BBN´s Annual Conference has been scheduled for November 6-8, 2023

This year, in the framework of a CIBER program to stimulate collaborations between clinical and technological groups, the conference will be organized in cooperation with a CIBER clinical area, CIBER-EHD: Hepatic and Digestive diseases. (An internal call of collaborative projects BBN-EHD will be open by). The scheme of the event will be slightly different from previous editions:

  • On Monday 6 the scientific sessions will be common for EHD and BBN, with appealing contents for the mixed audience.
  • On Tuesday 7 EHD and BBN sessions will be specific for each area in separate rooms (with common coffee break).
  • The anual session dedicated to NANBIOSIS is scheduled for the afternoon of the Tuesday 7th,
  • After this session we will cellebrate the annual meeting of the NANBIOSIS coordination Committee and the Scientific and Technical Advisory Board of NANBIOSIS.

We will come back with further details. Book the dates!

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Representatives of the Ministry of Science and Innovation visited unit 16 of NANBIOSIS

On May 16 representatives of the General Subdirectorate of Large Scientific-Technical Facilities of the Ministry of Science and Innovation visited unit 16 of NANBIOSIS (created by Centro de Investigación Biomédica en Red -CIBER-, and the University of Extermadura).

Mrs. Beatriz Albella Rodríguez and Mrs. María Jesús Marcos Crespo, got to know first-hand the facilities of unit 16 of the CTS NANBIOSIS of “Surface Characterization and Calorimetry .

The visit was guided by the Scientific Director of Unit 16 of NANBIOSIS, Maria Luisa González Martín, and by Mr. Javier de Francisco Morcillo, Director of the Secretariat for Scientific Infrastructure and Technological Development Vice President for Research and Transfer of the University of Extremadura

The reason for the visit was to receive information on the use of European Regional Development Funds that have served to improve the infrastructures of the Spanish Map of Singular Scientific-Technical Infrastructures (ICTS, in Spanish) to support scientific research.

During the last years, this unit 16 of NANBIOSIS ICTS has enlarged its capacities through the project FICTS1420-14-09, an investment of 1.3 million euros, co-financed with FEDER funds, the Ministry of Science and Innovation, and Junta de Extremadura, Regional Ministry of Economy, Science and Digital Agency.

This Unit 16, located in Badajoz, offers the performance of tasks of physical-chemical characterization of surfaces using techniques such as ellipsometry, calorimetry, X-ray photoelectronic spectroscopy (XPS), and detection of secondary ions by means of mass spectrometry by time of flight (Tof-SIMS).

Related News

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U6-E18. Freeze Dryer

Freeze drying (also known as lyophilization) is a water (or other solvents) removal process typically used to preserve materials, to extend their shelf life or reduce its weight. Freeze drying works by freezing the material, then reducing the pressure and adding heat to allow the frozen water in the material to change directly to a vapor (sublimation).

Freeze drying occurs in three phases:


Freezing can be done in a freezer, a chilled bath (shell freezer) or on a shelf in the freeze dryer. Cooling the material below its triple point ensures that sublimation, rather than melting, will occur. This preserves its physical form.

              2-Primary Drying

Freeze drying’s second phase is primary drying (sublimation), in which the pressure is lowered and heat is added to the material in order for the water to sublimate. About 95% of the water in the material is removed in this phase. Primary drying can be a slow process.

             3-Secondary Drying

Freeze drying’s final phase is secondary drying (adsorption), during which the ionically-bound water molecules are removed. Most materials can be dried to 1-5% residual moisture.

Technical Specifications:

  • Vacuum pump: 7 m3/h
  • Condenser min. Temperature: – 80º C


Solvent removal is typically used to preserve materials, to extend their shelf life or reduce its weight.

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U6-E17. Tangential flow filtration system

Tangential flow filtration (TFF)  is a process of separation widely used in bio-pharmaceutical and food industries. It is different from other filtration systems in that the fluid is passed parallel to the filter, rather than being pushed through a membrane perpendicularly which can clog the filter media. This method is preferred for its continuous filtration and reproducible performance. The particles that pass through the membrane, the permeate, are put off to the side, while the rest, the retentate, is recycled back to the feed.

 Technical Specifications:

  • Volume: 10 ml
  • Filtration volume rate: 0.01 to 2300 ml/min

Aplications: Tangential flow filtration is used in the following processes:

Concentration: Increases the concentration of a solution by removing fluids while keeping the solute molecules. This process is done by selecting a filter significantly smaller than the solute molecules to allow for a higher retention of solute molecules.

 Diafiltration:  The separation of small and large particles, leaving the smaller particles behind without altering the overall concentration.

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