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U16. Surface Characterization and Calorimetry Unit

Ciber bbn

U16. Surface Characterization and Calorimetry Unit

  • Scientific Director: Prof. M Luisa González Martín mlglez@unex.es
  • Scientific Coordinator: Prof. M Luisa González Martín mlglez@unex.es
  • Entities: Universidad de Extremadura
  • Address: Avda Elvas, S/N, 06006, Badajoz, Spain
  • Phone: +34 924 289 532
  • Web: WEB
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The purpose of this Unit is to give support for the analysis of surface composition to researchers. This facility allows a broad knowledge about the chemistry of surfaces by the combination of the information of elements presents and their coordination state, given by the XPS technique, and the molecular structure of surface provided by the ToF-SIMs equipment. Its capabilities permit to work with extended and powdered solids, including those from biological origin as cells and bacteria. The characteristics of thin films on surfaces, as thickness, composition or electrical conductivity, can be also analyzed in this unit by spectroscopic ellipsometry. In addition, calorimetric analysis can be performed to test surface reactivity on powdered solids. ITC calorimetry facility is also under the Unit scheme.

Surface analysis laboratory fulfils the ISO9001:2008 (ES050823-1).  Nanbiosis- U16-logo-ISO9001

Active projects

TitleFundin: OrganismCall: Funding source Role
SAF2017-90810-REDIStrategic Promotion and coordinated management of Nanbiosis: Pronanbiosis IIAgencia Estatal de Investigación (AEI)Acciones de dinamización «REDES DE EXCELENCIA» -ICTS 2017Partner
PICCOLO-732111Multimodal highly-sensitive PhotonICs endoscope for improve in vivo COLOn Cancer diagnosis and clinical decision supportEuropean Commission-H2020H2020-ICT-2016-1Partner
0624_2IQBIONEURO_6_EPromotion of an R&I network in biological chemistry for the diagnosis and treatment of neurological diseasesEuropean Union Interreg : European Territorial Co-operationPOCTEP Interreg España-PortugalPartner

Other projects

RefTitleFunding OrganismUnit Role



  • Monje A., Gonzalez-Garcia R., Fernandez-Calderon M.C., Hierro-Oliva M., Gonzalez-Martin M.L., Del Amo F.S.-L. et al. Surface topographical changes of a failing acid-etched long-term in function retrieved dental implant. Journal of Oral Implantology. 2016;42(1):12-16.
  • Constantino J.A., Delgado-Rastrollo M., Pacha-Olivenza M.A., Gonzalez-Martin M.L., Quiles M., Perez-Giraldo C. et al. In vivo bactericidal efficacy of the Ti6Al4V surface after ultraviolet C treatment. Journal of Orthopaedics and Traumatology. 2016;:1-9.
  • Rodriguez-Sanchez J., Gallardo-Moreno A.M., Bruque J.M., Gonzalez-Martin M.L.. Adsorption of human fibrinogen and albumin onto hydrophobic and hydrophilic Ti6Al4V powder. Applied Surface Science. 2016;376:269-275.
  • Constantino J.A., Delgado-Rastrollo M., Pacha-Olivenza M.A., Perez-Giraldo C., Quiles M., Gonzalez-Martin M.L. et al. In vivo bactericidal efficacy of farnesol on Ti6Al4V implants. Revista Espanola de Cirugia Ortopedica y Traumatologia. 2016;:-.
  • Crespo L., Hierro-Oliva M., Barriuso S., Vadillo-Rodriguez V., Montealegre M.A., Saldana L. et al. On the interactions of human bone cells with Ti6Al4V thermally oxidized by means of laser shock processing. Biomedical Materials (Bristol). 2016;11(1):-.
  • Pena-Gonzalez C.E., Garcia-Broncano P., Ottaviani M.F., Cangiotti M., Fattori A., Hierro-Oliva M. et al. Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization, and Antiviral Activity. Chemistry – A European Journal. 2016;22(9):2987-2999.
  • Cordoba A., Hierro-Oliva M., Pacha-Olivenza M.A., Fernandez-Calderon M.C., Perello J., Isern B. et al. Direct Covalent Grafting of Phytate to Titanium Surfaces through Ti-O-P Bonding Shows Bone Stimulating Surface Properties and Decreased Bacterial Adhesion. ACS Applied Materials and Interfaces. 2016;8(18):11326-11335.

News U16

21 Feb

The NABIHEAL Project Pioneers Wound Healing with New Biomimetic Matrices

Nearly 40 scientists across 7 countries are pioneering this breakthrough in wound healing using a nobel and affordable bio-inspired, anti-bacterial matrix. In addition to the vast consortium, the project also comprises 5 small and medium-sized enterprises (SMEs) and 9 academic institutions. These were convened last February at the University of Granada to share insights, progress, and strategies. According to an article published by UGR at the beginning of this month, about 40 researchers involved in the project have attended a meeting to share results and progress. The Horizon Europe project NABIHEAL, coordinated by the Biomedical Research Networking Center (CIBER) at[...]

08 Nov

Impactful research with NANBIOSIS participation in the Poster Tour of CIBER-BBN & CIBEREHD Annual Conference.

2023 CIBER-BBN Annual meeting has taken place at Santemar Hotel, in Santander during November 6-7. This year the format of our annual conferences has been changed towards a collective event scheme between the CIBER-BBN and CIBEREHD thematic areas. On Monday 6 the scientific sessions werecommon for EHD and BBN, with appealing contents for the mixed audience. On Tuesday 7 EHD and BBN sessions will specific for each area in separate rooms (with common coffee break). Posters of both areas were on display in the exhibit hall throughout the entirety of the Annual Meeting. Moreover, at the “Posters & beers” session (Monday[...]

08 Nov

NANBIOSIS sesion in the CIBER-BBN and CIBEREHD annual meeting. SAFE-N-MEDTECH Project: Outcomes and Future Prospects.

The annual conference of the scientific áreas of CIBER (the most important Centre for Biomedical Research in Spain) are hotly awaited every year for the CIBER community as a foro to be updated about emerging key technologies and discuss about research lines and results, find new opportunities to collaborate and join efforts towards common objectives. Moreover, this year, the Annual Conference of CIBER-BBN (Bioengineering, Biomaterials and Nanomedicine) has been organized as a collective event scheme together with the scientific area of CIBEREHD (Digestive and Liver Diseases). Both areas have already shared experiences of collaborative projects, demonstrating the complementarity of their fields.[...]

03 Jun

Representatives of the Ministry of Science and Innovation visited unit 16 of NANBIOSIS

On May 16 representatives of the General Subdirectorate of Large Scientific-Technical Facilities of the Ministry of Science and Innovation visited unit 16 of NANBIOSIS (created by Centro de Investigación Biomédica en Red -CIBER-, and the University of Extermadura). Mrs. Beatriz Albella Rodríguez and Mrs. María Jesús Marcos Crespo, got to know first-hand the facilities of unit 16 of the CTS NANBIOSIS of “Surface Characterization and Calorimetry“ . The visit was guided by the Scientific Director of Unit 16 of NANBIOSIS, Maria Luisa González Martín, and by Mr. Javier de Francisco Morcillo, Director of the Secretariat for Scientific Infrastructure and Technologica[...]

12 May

NABIHEAL project launches website

The website for NABIHEAL, an EU-funded Horizon Europe project developing biomaterials for complex wound healing, is now online. The Horizon Europe project NABIHEALi project is coordinated by the Center for Biomedical Research Network (CIBER) at the Institute of Materials Science of Barcelona (ICMAB-CSIC). This project will apply one the “Cutting Edge Biomedical Solutions” of NANBIOSIS for the preparation of different nanoestructures with antimicrobial properties, required for the development of the final multifunctional wound healing biomaterials. This case will gather the expertise of two NANBIOSIS unit: NANBIOSIS U6 will produce and characterize these nanoestructures with antimicrobial properties, which will be tested in NANBIOSIS U16. Find out mor[...]

24 Mar

NANBIOSIS U16 enlarges its capacities with a new FlexPS-ARPES-E kit

NANBIOSIS unit 16 Surface Characterization and Calorimetry Unit form CIBER-BBN and University of Extremadura has recently incorporated new equipment acquired through the execution of the project FICTS1420-14-09, cofinanced with FEDER funds, the Ministry of Economy and Competitiveness and Junta de Extremadura, Regional Ministry of Economy, Science and Digital Agency. A new FlexPS-ARPES-E kit, manufactured by SPECS, is now available for use by researchers This new resource uses the technique of photoelectron spectroscopy generated by X-rays to analyze the chemical composition of a surface. The electrons given off by the irradiated surface generate a fingerprint of the molecules that make up that surface, yielding information[...]

16 Jan

New European Project NABIHEAL in biomaterials for complex wound healing

The Horizon Europe project NABIHEAL, coordinated by the Center for Biomedical Research Network (CIBER) at the Institute of Materials Science of Barcelona (ICMAB-CSIC), was launched on 11-12 January 2023 in Barcelona with the first meeting of the international consortium, formed by 14 partners from 7 countries, including research centers, universities, and private companies.  This project will apply one the “Cutting Edge Biomedical Solutions” of NANBIOSIS for the preparation of different nanoestructures with antimicrobial properties, required for the development of the final multifunctional wound healing biomaterials. This case will gather the expertise of two NANBIOSIS unit: NANBIOSIS U6 will produce and[...]

10 Aug

New leaflets available of new equipment at NANBIOSIS Unit 16

We are delighted to announce the publication of our new brochures which reflects the new equiments and capabilities incorporated to NANBIOSI U16 Surface Characterization and Calorimetry Unit. The equipment is available has been incorporated to the Unit thanks to European Regional Development Fund (FEDER) allocated by the Goberment of Spain for the development of ICTSs, specifically through the Project FICTS-1420-14-09. TOFSIMS_EN-1Download Profilometry_ENDownload Goniometer_ENDownload Further information: NANBIOSIS News[...]

U16-Surface Characterization and Calorimetry Unit
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U17. Confocal Microscopy Service

Ciber bbn

U17. Confocal Microscopy Service

  • Scientific Director: Dr. Gemma Pascual gemma.pascual@uah.es
  • Scientific Coordinator: Dr. Selma Benito  selma.benito@uah.es
  • Technical Coordinator:  Mª Isabel Trabado unidad.cultivos@uah.es
  • Entities: Cell Culture Unit. Modulo IV, Planta Baja. Facultad de Medicina Universidad de Alcalá (UAH)
  • Address: Ctra. Madrid-Barcelona, km. 33,6, 28871, Alcalá de Henares, Madrid, Spain
  • Phone: +34 918 854 535
  • Web: WEB


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Located in the Cell Culture Unit, Faculty of Medicine, University of Alcalá, has a room perfectly suited to host a Confocal Microscope service that provides 4 lasers and cell incubation cabin. This Unit is coordinated by Dr. Gemma Pascual, PI of the Translational Research and Tissue Engineering Group at the University of Alcalá.



U17. Services & Rates

Active projects

Title Fundin: Organism Call: Funding source Role
SAF2017-90810-REDI Strategic Promotion and coordinated management of Nanbiosis: Pronanbiosis II Agencia Estatal de Investigación (AEI) Acciones de dinamización «REDES DE EXCELENCIA» -ICTS 2017 Partner
PICCOLO-732111 Multimodal highly-sensitive PhotonICs endoscope for improve in vivo COLOn Cancer diagnosis and clinical decision support European Commission-H2020 H2020-ICT-2016-1 Partner
0624_2IQBIONEURO_6_E Promotion of an R&I network in biological chemistry for the diagnosis and treatment of neurological diseases European Union Interreg : European Territorial Co-operation POCTEP Interreg España-Portugal Partner



  • Pascual G., Sotomayor S., Adel F., Perez-Kohler B., Rodriguez M., Cifuentes A. et al. Remodeling of Noncrosslinked Acellular Dermal Matrices in a Rabbit Model of Ventral Hernia Repair. European Surgical Research. 2016;:32-48.
  • Calvo B., Pascual G., Pena E., Perez-Kholer B., Rodriguez M., Bellon J.M.. Biomechanical and morphological study of a new elastic mesh (Ciberlastic) to repair abdominal wall defects. Journal of the Mechanical Behavior of Biomedical Materials. 2016;59:366-378.
  • Cordero A., Hernandez-Gascon B., Pascual G., Bellon J.M., Calvo B., Pena E.. Biaxial Mechanical Evaluation of Absorbable and Nonabsorbable Synthetic Surgical Meshes Used for Hernia Repair: Physiological Loads Modify Anisotropy Response. Annals of Biomedical Engineering. 2016;:1-8.

News U17

03 Jun

How to accomplish researchers’ goals with Confocal Microscopy: the tools, the know-how and the expertise you need

NANBIOSIS Unit 17 (Confocal Microscopy) is a CIBER-BBN unit located in the Cell Culture Unit, CAI Medicine and Biology, Faculty of Medicine at the University of Alcala. This unit of the ICTS NANBIOSIS supports researchers interested on their different studies visualizing diverse samples as tissues, cells, bacterial biofilms, etc. This unit owns the tools, the know-how and the expertise to accomplish researchers’ goals either by transmission or reflection fluorescent. We are happy of sharing this video in which researchers of Unit 17 show all the steps required for the visualization of the PV-1 molecule, also known as PLVAP, on t[...]

18 Apr

Experimental & molecular medicine: a new article with NANBIOSIS U17

ICTS-NANBIOSIS. UNIT 17 CONFOCAL MICROSCOPY SERVICE. (CIBER-BNN. UNIVERSITY OF ALCALÁ) The UAH research groupTranslational research of chronic diseases associated with aging and kidney disease has recently published an article in which unit NANBIOSIS unit 17 and Leica SP5 confocal microscope has had a great contribution Located in the Support Center for Research in Medicine and Biology, Faculty of Medicine and Healthe Sciences, University of Alcalá (UAH). The Unit is equipped with a Leica TCS-SP5 confocal microscope. The confocal module is equipped with three spectral detection channels, AOBS (Acousto-optical beam splitter) and a resonant scanner system that allows analysis at hig[...]

17 Feb

The integrin beta1 modulator Tirofiban prevents adipogenesis and obesity by the overexpression of integrin-linked kinase: a pre-clinical approach in vitro and in vivo

Obesity is caused by the enlargement of the white adipose tissue (WAT) depots, characterized by the hypertrophic enlargement of malfunctioning adipocytes within WAT, which increases the storage of triglycerides (TG) in the lipid droplets (LD). Adipogenesis pathways as well as the expression and activity of some extracellular matrix receptors integrins are upregulated. Integrinβ1 (INTB1) is the main isoform involved in WAT remodeling during obesity and insulin resistance-related diseases. We recently described Integrin Linked Kinase (ILK), a scafold protein recruited by INTB1, as an important mediator of WAT remodeling and insulin resistance. As the few approved drugs to fight obesity hav[...]

08 Oct

“Ring Around the Rosy”

C2C12 myoblast cells differentiating into myotubes and adopting unusual shapes have been obtained and captured by resarchers of UAH and NANBIOSIS Unit 17 Confocal Microscopy Service (of CIBER-BBN and UAH) and and chosen photo of the month by the Spanish Society of Biochemistry and Molecular Biology (SEBBM) The picture illustrates the month of October on the calendar that the SEBBM publishes and distributes annually among all partners, and is part of the gallery of images that illustrate the activities of the SEBBM. Likewise, the photography will participate in the “Best Scientific Image of the Year” contest. The winning image is[...]

25 Apr

Uraemic toxins impair skeletal muscle regeneration by inhibiting myoblast proliferation, reducing myogenic differentiation, and promoting muscular fibrosis

Elena Alcalde‑Estévez, Patricia Sosa, Ana Asenjo‑Bueno, Patricia Plaza, Gemma Olmos, Manuel Naves‑Díaz, Diego Rodríguez‑Puyol, Susana López‑Ongil & María P. Ruiz‑Torres, are the authors of an article recently published in the Journal Scientific Reports, of Nature Research, ·mentioning the collaboration in the investigation of the ICTS “NANBIOSIS” U17 Confocal Microscopy Service of CIBER-BNN and the University of Alcalá. Uremic toxins (UT) increase in the serum in parallel with a decrease in the glomerular filtration rate and the development of sarcopenia in patients with chronic kidney disease (CKD). This study analyses the role of UTs in sarcopenia associated with CKD in different[...]

07 Apr

Toxicity evaluation on non-target organisms with the collaboration of NANBIOSIS U17 Confocal microscopy

Sara Jiménez-Jiménez, Georgiana Amariei, Karina Boltes, María Ángeles García and María Luisa Marina have recently published an article in the Journal of Chromatography A, ·mentioning the collaboration in the investigation of the ICTS “NANBIOSIS” U17 Confocal Microscopy Service of CIBER-BNN and the University of Alcalá. The echocytotoxicity of racemic panthenol and dexpanthenol at different concentrations and exposure times in Spirodela polyrhiza has been studied using NANBIOSIS U17 Confocal Microscopy Service “Panthenol (racemic mixture) and its isomer dexpanthenol have been classified as toxic for the aquatic environment by the European Regulation (EC 1272/2008). These studies are based on the natural emission[...]

11 Feb

NANBIOSIS Scientific Women in the International Day of Women and Girls in Science

Today February 11 is the International Day of Women and Girls in Science, a day to raise awareness of the gender gap in science and technology. According to the United Nations, while yet women and girls continue to be excluded from participating fully in science, science and gender equality are vital to achieve the internationally agreed development goals, including the 2030 Agenda for Sustainable Development. Thus, in recent years, the international community has made a great effort to inspire and promote the participation of women and girls in science. NANBIOSIS wants to acknowledge  the efforts made by scientific women who struggle every day to contribut[...]

13 Jul

Cardiac hypertrophy research with NANBIOSIS unit 17 Confocal Microscopy Service participation

A new article has been recently published about Cardiac hypertrophy research in the Scientific Reports Jorunal by NatureResarch, counting with the expertise of NANBIOSIS unit 17 Confocal Microscopy Service form CIBER-BBN and University of Alcalá de Henares. Cardiac hypertrophy is the abnormal enlargement, or thickening, of the heart muscle, resulting from increases in cardiomyocyte size and changes in other heart muscle components, such as extracellular matrix. This article relates more especifically with the link between long term exposure to xenoestrogen Bisphenol-A and adverse cardiovascular effects and the role of necroptosis in cardiac response to BPA had not yet been explored.[...]

U17-Confocal Microscopy Service
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